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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACPP-RDH11 (FusionGDB2 ID:HG55TG51109)

Fusion Gene Summary for ACPP-RDH11

check button Fusion gene summary
Fusion gene informationFusion gene name: ACPP-RDH11
Fusion gene ID: hg55tg51109
HgeneTgene
Gene symbol

ACPP

RDH11

Gene ID

55

51109

Gene nameacid phosphatase 3retinol dehydrogenase 11
Synonyms5'-NT|ACP-3|ACPP|TM-PAPARSDR1|CGI82|HCBP12|MDT1|PSDR1|RALR1|RDJCSS|SCALD|SDR7C1
Cytomap('ACPP')('RDH11')

3q22.1

14q24.1

Type of geneprotein-codingprotein-coding
Descriptionprostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphataseretinol dehydrogenase 11HCV core-binding protein HCBP12androgen-regulated short-chain dehydrogenase/reductase 1prostate short-chain dehydrogenase reductase 1retinal reductase 1retinol dehydrogenase 11 (all-trans/9-cis/11-cis)short chain dehydrogenas
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336375, ENST00000351273, 
ENST00000475741, ENST00000489084, 
Fusion gene scores* DoF score28 X 17 X 4=19049 X 7 X 5=315
# samples 319
** MAII scorelog2(31/1904*10)=-2.61869335803371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACPP [Title/Abstract] AND RDH11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACPP(132075699)-RDH11(68157138), # samples:1
Anticipated loss of major functional domain due to fusion event.ACPP-RDH11 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACPP-RDH11 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACPP

GO:0046085

adenosine metabolic process

18940592

TgeneRDH11

GO:0001523

retinoid metabolic process

12226107

TgeneRDH11

GO:0042574

retinal metabolic process

12807874

TgeneRDH11

GO:0110095

cellular detoxification of aldehyde

12807874


check buttonFusion gene breakpoints across ACPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RDH11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5789-01AACPPchr3

132075699

+RDH11chr14

68157138

-


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Fusion Gene ORF analysis for ACPP-RDH11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336375ENST00000428130ACPPchr3

132075699

+RDH11chr14

68157138

-
5CDS-intronENST00000351273ENST00000428130ACPPchr3

132075699

+RDH11chr14

68157138

-
5CDS-intronENST00000475741ENST00000428130ACPPchr3

132075699

+RDH11chr14

68157138

-
Frame-shiftENST00000336375ENST00000381346ACPPchr3

132075699

+RDH11chr14

68157138

-
Frame-shiftENST00000336375ENST00000553384ACPPchr3

132075699

+RDH11chr14

68157138

-
Frame-shiftENST00000475741ENST00000381346ACPPchr3

132075699

+RDH11chr14

68157138

-
Frame-shiftENST00000475741ENST00000553384ACPPchr3

132075699

+RDH11chr14

68157138

-
In-frameENST00000351273ENST00000381346ACPPchr3

132075699

+RDH11chr14

68157138

-
In-frameENST00000351273ENST00000553384ACPPchr3

132075699

+RDH11chr14

68157138

-
intron-3CDSENST00000489084ENST00000381346ACPPchr3

132075699

+RDH11chr14

68157138

-
intron-3CDSENST00000489084ENST00000553384ACPPchr3

132075699

+RDH11chr14

68157138

-
intron-intronENST00000489084ENST00000428130ACPPchr3

132075699

+RDH11chr14

68157138

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000351273ACPPchr3132075699+ENST00000381346RDH11chr1468157138-32111188261690554
ENST00000351273ACPPchr3132075699+ENST00000553384RDH11chr1468157138-26481188261690554

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000351273ENST00000381346ACPPchr3132075699+RDH11chr1468157138-0.0005003130.9994997
ENST00000351273ENST00000553384ACPPchr3132075699+RDH11chr1468157138-0.0022701170.99772996

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Fusion Genomic Features for ACPP-RDH11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACPP-RDH11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132075699/chr14:68157138)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRDH11chr3:132075699chr14:68157138ENST000004281300648_540249.0Nucleotide bindingNADP
TgeneRDH11chr3:132075699chr14:68157138ENST000004281300622_3180249.0Topological domainCytoplasmic
TgeneRDH11chr3:132075699chr14:68157138ENST00000428130061_210249.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRDH11chr3:132075699chr14:68157138ENST000003813463748_54151319.0Nucleotide bindingNADP
TgeneRDH11chr3:132075699chr14:68157138ENST000005533843748_54138306.0Nucleotide bindingNADP
TgeneRDH11chr3:132075699chr14:68157138ENST000003813463722_318151319.0Topological domainCytoplasmic
TgeneRDH11chr3:132075699chr14:68157138ENST000005533843722_318138306.0Topological domainCytoplasmic
TgeneRDH11chr3:132075699chr14:68157138ENST00000381346371_21151319.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneRDH11chr3:132075699chr14:68157138ENST00000553384371_21138306.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for ACPP-RDH11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1460_1460_1_ACPP-RDH11_ACPP_chr3_132075699_ENST00000351273_RDH11_chr14_68157138_ENST00000381346_length(transcript)=3211nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGGTCACTTCCTCCTAACCCATCTGCTGCTAGAGAAACTAAAGGAATCAGCCCCATCAAGGATAGTAAATGTGT
CTTCCCTCGCACATCACCTGGGAAGGATCCACTTCCATAACCTGCAGGGCGAGAAATTCTACAATGCAGGCCTGGCCTACTGTCACAGCA
AGCTAGCCAACATCCTCTTCACCCAGGAACTGGCCCGGAGACTAAAAGGCTCTGGCGTTACGACGTATTCTGTACACCCTGGCACAGTCC
AATCTGAACTGGTTCGGCACTCATCTTTCATGAGATGGATGTGGTGGCTTTTCTCCTTTTTCATCAAGACTCCTCAGCAGGGAGCCCAGA
CCAGCCTGCACTGTGCCTTAACAGAAGGTCTTGAGATTCTAAGTGGGAATCATTTCAGTGACTGTCATGTGGCATGGGTCTCTGCCCAAG
CTCGTAATGAGACTATAGCAAGGCGGCTGTGGGACGTCAGTTGTGACCTGCTGGGCCTCCCAATAGACTAACAGGCAGTGCCAGTTGGAC
CCAAGAGAAGACTGCAGCAGACTACACAGTACTTCTTGTCAAAATGATTCTCCTTCAAGGTTTTCAAAACCTTTAGCACAAAGAGAGCAA
AACCTTCCAGCCTTGCCTGCTTGGTGTCCAGTTAAAACTCAGTGTACTGCCAGATTCGTCTAAATGTCTGTCATGTCCAGATTTACTTTG
CTTCTGTTACTGCCAGAGTTACTAGAGATATCATAATAGGATAAGAAGACCCTCATATGACCTGCACAGCTCATTTTCCTTCTGAAAGAA
ACTACTACCTAGGAGAATCTAAGCTATAGCAGGGATGATTTATGCAAATTTGAACTAGCTTCTTTGTTCACAATTCAGTTCCTCCCAACC
AACCAGTCTTCACTTCAAGAGGGCCACACTGCAACCTCAGCTTAACATGAATAACAAAGACTGGCTCAGGAGCAGGGCTTGCCCAGGCAT
GGTGGATCACCGGAGGTCAGTAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCACCTCTACTAAAAATTGTGTATATCTTTGTGTG
TCTTCCTGTTTATGTGTGCCAAGGGAGTATTTTCACAAAGTTCAAAACAGCCACAATAATCAGAGATGGAGCAAACCAGTGCCATCCAGT
CTTTATGCAAATGAAATGCTGCAAAGGGAAGCAGATTCTGTATATGTTGGTAACTACCCACCAAGAGCACATGGGTAGCAGGGAAGAAGT
AAAAAAAGAGAAGGAGAATACTGGAAGATAATGCACAAAATGAAGGGACTAGTTAAGGATTAACTAGCCCTTTAAGGATTAACTAGTTAA
GGATTAATAGCAAAAGATATTAAATATGCTAACATAGCTATGGAGGAATTGAGGGCAAGCACCCAGGACTGATGAGGTCTTAACAAAAAC
CAGTGTGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAATCCTAAAAACAAACAAACAAAAAAAACAATTCTTCATTCAGAAAAATTATCT
TAGGGACTGATATTGGTAATTATGGTCAATTTAATAATATTTTGGGGCATTTCCTTACATTGTCTTGACAAGATTAAAATGTCTGTGCCA
AAATTTTGTATTTTATTTGGAGACTTCTTATCAAAAGTAATGCTGCCAAAGGAAGTCTAAGGAATTAGTAGTGTTCCCATCACTTGTTTG
GAGTGTGCTATTCTAAAAGATTTTGATTTCCTGGAATGACAATTATATTTTAACTTTGGTGGGGGAAAGAGTTATAGGACCACAGTCTTC
ACTTCTGATACTTGTAAATTAATCTTTTATTGCACTTGTTTTGACCATTAAGCTATATGTTTAGAAATGGTCATTTTACGGAAAAATTAG
AAAAATTCTGATAATAGTGCAGAATAAATGAATTAATGTTTTACTTAATTTATATTGAACTGTCAATGACAAATAAAAATTCTTTTTGAT

>1460_1460_1_ACPP-RDH11_ACPP_chr3_132075699_ENST00000351273_RDH11_chr14_68157138_ENST00000381346_length(amino acids)=554AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQ
ELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARR

--------------------------------------------------------------
>1460_1460_2_ACPP-RDH11_ACPP_chr3_132075699_ENST00000351273_RDH11_chr14_68157138_ENST00000553384_length(transcript)=2648nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGGTCACTTCCTCCTAACCCATCTGCTGCTAGAGAAACTAAAGGAATCAGCCCCATCAAGGATAGTAAATGTGT
CTTCCCTCGCACATCACCTGGGAAGGATCCACTTCCATAACCTGCAGGGCGAGAAATTCTACAATGCAGGCCTGGCCTACTGTCACAGCA
AGCTAGCCAACATCCTCTTCACCCAGGAACTGGCCCGGAGACTAAAAGGCTCTGGCGTTACGACGTATTCTGTACACCCTGGCACAGTCC
AATCTGAACTGGTTCGGCACTCATCTTTCATGAGATGGATGTGGTGGCTTTTCTCCTTTTTCATCAAGACTCCTCAGCAGGGAGCCCAGA
CCAGCCTGCACTGTGCCTTAACAGAAGGTCTTGAGATTCTAAGTGGGAATCATTTCAGTGACTGTCATGTGGCATGGGTCTCTGCCCAAG
CTCGTAATGAGACTATAGCAAGGCGGCTGTGGGACGTCAGTTGTGACCTGCTGGGCCTCCCAATAGACTAACAGGCAGTGCCAGTTGGAC
CCAAGAGAAGACTGCAGCAGACTACACAGTACTTCTTGTCAAAATGATTCTCCTTCAAGGTTTTCAAAACCTTTAGCACAAAGAGAGCAA
AACCTTCCAGCCTTGCCTGCTTGGTGTCCAGTTAAAACTCAGTGTACTGCCAGATTCGTCTAAATGTCTGTCATGTCCAGATTTACTTTG
CTTCTGTTACTGCCAGAGTTACTAGAGATATCATAATAGGATAAGAAGACCCTCATATGACCTGCACAGCTCATTTTCCTTCTGAAAGAA
ACTACTACCTAGGAGAATCTAAGCTATAGCAGGGATGATTTATGCAAATTTGAACTAGCTTCTTTGTTCACAATTCAGTTCCTCCCAACC
AACCAGTCTTCACTTCAAGAGGGCCACACTGCAACCTCAGCTTAACATGAATAACAAAGACTGGCTCAGGAGCAGGGCTTGCCCAGGCAT
GGTGGATCACCGGAGGTCAGTAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCACCTCTACTAAAAATTGTGTATATCTTTGTGTG
TCTTCCTGTTTATGTGTGCCAAGGGAGTATTTTCACAAAGTTCAAAACAGCCACAATAATCAGAGATGGAGCAAACCAGTGCCATCCAGT
CTTTATGCAAATGAAATGCTGCAAAGGGAAGCAGATTCTGTATATGTTGGTAACTACCCACCAAGAGCACATGGGTAGCAGGGAAGAAGT
AAAAAAAGAGAAGGAGAATACTGGAAGATAATGCACAAAATGAAGGGACTAGTTAAGGATTAACTAGCCCTTTAAGGATTAACTAGTTAA
GGATTAATAGCAAAAGATATTAAATATGCTAACATAGCTATGGAGGAATTGAGGGCAAGCACCCAGGACTGATGAGGTCTTAACAAAAAC

>1460_1460_2_ACPP-RDH11_ACPP_chr3_132075699_ENST00000351273_RDH11_chr14_68157138_ENST00000553384_length(amino acids)=554AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQ
ELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACPP-RDH11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACPP-RDH11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACPP-RDH11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4015242RETINAL DYSTROPHY, JUVENILE CATARACTS, AND SHORT STATURE SYNDROME1CTD_human;ORPHANET