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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACPP-TRPM4 (FusionGDB2 ID:HG55TG54795)

Fusion Gene Summary for ACPP-TRPM4

Fusion gene summary

Fusion gene information	Fusion gene name: ACPP-TRPM4
	Fusion gene ID: hg55tg54795
		Hgene	Tgene
	Gene symbol	ACPP	TRPM4
	Gene ID	55	54795
	Gene name	acid phosphatase 3	transient receptor potential cation channel subfamily M member 4
	Synonyms	5'-NT\|ACP-3\|ACPP\|TM-PAP	EKVP6\|LTrpC4\|PFHB1B\|TRPM4B\|hTRPM4
	Cytomap	('ACPP')('TRPM4') 3q22.1	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	prostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatase	transient receptor potential cation channel subfamily M member 4calcium-activated non-selective cation channel 1long transient receptor potential channel 4melastatin-4
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000336375, ENST00000351273, ENST00000475741, ENST00000489084,
Fusion gene scores	* DoF score	28 X 17 X 4=1904	10 X 9 X 4=360
	# samples	31	13
	** MAII score	log2(31/1904*10)=-2.61869335803371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/360*10)=-1.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ACPP [Title/Abstract] AND TRPM4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACPP(132075699)-TRPM4(49705220), # samples:1
Anticipated loss of major functional domain due to fusion event.	ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ACPP-TRPM4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACPP	GO:0046085	adenosine metabolic process	18940592
Tgene	TRPM4	GO:0002724	regulation of T cell cytokine production	20656926
Tgene	TRPM4	GO:0008284	positive regulation of cell proliferation	20625999
Tgene	TRPM4	GO:0016925	protein sumoylation	19726882
Tgene	TRPM4	GO:0019722	calcium-mediated signaling	27207958
Tgene	TRPM4	GO:0051289	protein homotetramerization	29211723\|29217581
Tgene	TRPM4	GO:0090263	positive regulation of canonical Wnt signaling pathway	20625999
Tgene	TRPM4	GO:0098662	inorganic cation transmembrane transport	29211723
Tgene	TRPM4	GO:0098719	sodium ion import across plasma membrane	27207958

Fusion gene breakpoints across ACPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRPM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-A65M	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+

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Fusion Gene ORF analysis for ACPP-TRPM4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000336375	ENST00000601347	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
5CDS-intron	ENST00000351273	ENST00000601347	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
5CDS-intron	ENST00000475741	ENST00000601347	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
Frame-shift	ENST00000336375	ENST00000252826	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
Frame-shift	ENST00000336375	ENST00000355712	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
Frame-shift	ENST00000336375	ENST00000427978	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
Frame-shift	ENST00000475741	ENST00000252826	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
Frame-shift	ENST00000475741	ENST00000355712	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
Frame-shift	ENST00000475741	ENST00000427978	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
In-frame	ENST00000351273	ENST00000252826	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
In-frame	ENST00000351273	ENST00000355712	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
In-frame	ENST00000351273	ENST00000427978	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
intron-3CDS	ENST00000489084	ENST00000252826	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
intron-3CDS	ENST00000489084	ENST00000355712	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
intron-3CDS	ENST00000489084	ENST00000427978	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+
intron-intron	ENST00000489084	ENST00000601347	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000351273

ACPP

chr3

132075699

ENST00000252826

TRPM4

chr19

49705220

2218

1188

1879

617

ENST00000351273

ACPP

chr3

132075699

ENST00000427978

TRPM4

chr19

49705220

2062

1188

1879

617

ENST00000351273

ACPP

chr3

132075699

ENST00000355712

TRPM4

chr19

49705220

2216

1188

1879

617

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000351273	ENST00000252826	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+	0.004512168	0.99548787
ENST00000351273	ENST00000427978	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+	0.005343844	0.9946562
ENST00000351273	ENST00000355712	ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+	0.004547348	0.9954527

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Fusion Genomic Features for ACPP-TRPM4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+	4.72E-06	0.99999523
ACPP	chr3	132075699	+	TRPM4	chr19	49705220	+	4.72E-06	0.99999523

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACPP-TRPM4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132075699/chr19:49705220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

1134_1187

984

1215.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

1134_1187

839

1070.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

964_984

839

1070.0

Intramembrane

Pore-forming

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

975_977

839

1070.0

Motif

Selectivity filter

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

1076_1176

984

1215.0

Region

Note=Calmodulin-binding

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

1076_1176

839

1070.0

Region

Note=Calmodulin-binding

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

1041_1214

984

1215.0

Topological domain

Cytoplasmic

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

985_1019

984

1215.0

Topological domain

Extracellular

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

1041_1214

839

1070.0

Topological domain

Cytoplasmic

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

885_886

839

1070.0

Topological domain

Extracellular

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

911_930

839

1070.0

Topological domain

Cytoplasmic

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

952_963

839

1070.0

Topological domain

Extracellular

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

985_1019

839

1070.0

Topological domain

Extracellular

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

1020_1040

984

1215.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

1020_1040

839

1070.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

864_884

839

1070.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

887_910

839

1070.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

931_951

839

1070.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

964_984

984

1215.0

Intramembrane

Pore-forming

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

975_977

984

1215.0

Motif

Selectivity filter

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

1_782

984

1215.0

Topological domain

Cytoplasmic

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

804_814

984

1215.0

Topological domain

Extracellular

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

836_863

984

1215.0

Topological domain

Cytoplasmic

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

885_886

984

1215.0

Topological domain

Extracellular

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

911_930

984

1215.0

Topological domain

Cytoplasmic

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

952_963

984

1215.0

Topological domain

Extracellular

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

1_782

839

1070.0

Topological domain

Cytoplasmic

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

804_814

839

1070.0

Topological domain

Extracellular

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

836_863

839

1070.0

Topological domain

Cytoplasmic

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

783_803

984

1215.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

815_835

984

1215.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

864_884

984

1215.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

887_910

984

1215.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000252826

931_951

984

1215.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

783_803

839

1070.0

Transmembrane

Helical

Tgene

TRPM4

chr3:132075699

chr19:49705220

ENST00000427978

815_835

839

1070.0

Transmembrane

Helical

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Fusion Gene Sequence for ACPP-TRPM4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>1471_1471_1_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000252826_length(transcript)=2218nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGGCCCTCATGGAGCACAGCAACTGCTCGTCGGAGCCCGGCTTCTGGGCACACCCTCCTGGGGCCCAGGCGG
GCACCTGCGTCTCCCAGTATGCCAACTGGCTGGTGGTGCTGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGC
TCATTGCCATGTTCAGTTACACATTCGGCAAAGTACAGGGCAACAGCGATCTCTACTGGAAGGCGCAGCGTTACCGCCTCATCCGGGAAT
TCCACTCTCGGCCCGCGCTGGCCCCGCCCTTTATCGTCATCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCC
CCCAGCCGTCCTCCCCGGCCCTCGAGCATTTCCGGGTTTACCTTTCTAAGGAAGCCGAGCGGAAGCTGCTAACGTGGGAATCGGTGCATA
AGGAGAACTTTCTGCTGGCACGCGCTAGGGACAAGCGGGAGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAAGGTGGACTTGGCAC
TGAAACAGCTGGGACACATCCGCGAGTACGAACAGCGCCTGAAAGTGCTGGAGCGGGAGGTCCAGCAGTGTAGCCGCGTCCTGGGGTGGG
TGGCCGAGGCCCTGAGCCGCTCTGCCTTGCTGCCCCCAGGTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAGACTGAGCCCTGCTGG
CGGACTTCAAGGAGAAGCCCCCACAGGGGATTTTGCTCCTAGAGTAAGGCTCATCTGGGCCTCGGCCCCCGCACCTGGTGGCCTTGTCCT
TGAGGTGAGCCCCATGTCCATCTGGGCCACTGTCAGGACCACCTTTGGGAGTGTCATCCTTACAAACCACAGCATGCCCGGCTCCTCCCA
GAACCAGTCCCAGCCTGGGAGGATCAAGGCCTGGATCCCGGGCCGTTATCCATCTGGAGGCTGCAGGGTCCTTGGGGTAACAGGGACCAC
AGACCCCTCACCACTCACAGATTCCTCACACTGGGGAAATAAAGCCATTTCAGAGGAA

>1471_1471_1_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000252826_length(amino acids)=617AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTF
GKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARA
RDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLPPGGPPPPDLPGSKD

--------------------------------------------------------------
>1471_1471_2_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000355712_length(transcript)=2216nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGGCCCTCATGGAGCACAGCAACTGCTCGTCGGAGCCCGGCTTCTGGGCACACCCTCCTGGGGCCCAGGCGG
GCACCTGCGTCTCCCAGTATGCCAACTGGCTGGTGGTGCTGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGC
TCATTGCCATGTTCAGTTACACATTCGGCAAAGTACAGGGCAACAGCGATCTCTACTGGAAGGCGCAGCGTTACCGCCTCATCCGGGAAT
TCCACTCTCGGCCCGCGCTGGCCCCGCCCTTTATCGTCATCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCC
CCCAGCCGTCCTCCCCGGCCCTCGAGCATTTCCGGGTTTACCTTTCTAAGGAAGCCGAGCGGAAGCTGCTAACGTGGGAATCGGTGCATA
AGGAGAACTTTCTGCTGGCACGCGCTAGGGACAAGCGGGAGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAAGGTGGACTTGGCAC
TGAAACAGCTGGGACACATCCGCGAGTACGAACAGCGCCTGAAAGTGCTGGAGCGGGAGGTCCAGCAGTGTAGCCGCGTCCTGGGGTGGG
TGGCCGAGGCCCTGAGCCGCTCTGCCTTGCTGCCCCCAGGTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAGACTGAGCCCTGCTGG
CGGACTTCAAGGAGAAGCCCCCACAGGGGATTTTGCTCCTAGAGTAAGGCTCATCTGGGCCTCGGCCCCCGCACCTGGTGGCCTTGTCCT
TGAGGTGAGCCCCATGTCCATCTGGGCCACTGTCAGGACCACCTTTGGGAGTGTCATCCTTACAAACCACAGCATGCCCGGCTCCTCCCA
GAACCAGTCCCAGCCTGGGAGGATCAAGGCCTGGATCCCGGGCCGTTATCCATCTGGAGGCTGCAGGGTCCTTGGGGTAACAGGGACCAC
AGACCCCTCACCACTCACAGATTCCTCACACTGGGGAAATAAAGCCATTTCAGAGG

>1471_1471_2_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000355712_length(amino acids)=617AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTF
GKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARA
RDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLPPGGPPPPDLPGSKD

--------------------------------------------------------------
>1471_1471_3_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000427978_length(transcript)=2062nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGGCCCTCATGGAGCACAGCAACTGCTCGTCGGAGCCCGGCTTCTGGGCACACCCTCCTGGGGCCCAGGCGG
GCACCTGCGTCTCCCAGTATGCCAACTGGCTGGTGGTGCTGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGC
TCATTGCCATGTTCAGTTACACATTCGGCAAAGTACAGGGCAACAGCGATCTCTACTGGAAGGCGCAGCGTTACCGCCTCATCCGGGAAT
TCCACTCTCGGCCCGCGCTGGCCCCGCCCTTTATCGTCATCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCC
CCCAGCCGTCCTCCCCGGCCCTCGAGCATTTCCGGGTTTACCTTTCTAAGGAAGCCGAGCGGAAGCTGCTAACGTGGGAATCGGTGCATA
AGGAGAACTTTCTGCTGGCACGCGCTAGGGACAAGCGGGAGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAAGGTGGACTTGGCAC
TGAAACAGCTGGGACACATCCGCGAGTACGAACAGCGCCTGAAAGTGCTGGAGCGGGAGGTCCAGCAGTGTAGCCGCGTCCTGGGGTGGG
TGGCCGAGGCCCTGAGCCGCTCTGCCTTGCTGCCCCCAGGTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAGACTGAGCCCTGCTGG
CGGACTTCAAGGAGAAGCCCCCACAGGGGATTTTGCTCCTAGAGTAAGGCTCATCTGGGCCTCGGCCCCCGCACCTGGTGGCCTTGTCCT
TGAGGTGAGCCCCATGTCCATCTGGGCCACTGTCAGGACCACCTTTGGGAGTGTCATCCTTACAAACCACAGCATGCCCGGC

>1471_1471_3_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000427978_length(amino acids)=617AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTF
GKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARA
RDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLPPGGPPPPDLPGSKD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACPP-TRPM4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ACPP-TRPM4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ACPP-TRPM4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C1142166	Brugada Syndrome (disorder)	7	CLINGEN;ORPHANET
Tgene		C1970298	Progressive Familial Heart Block, Type Ib	6	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C1879286	Hereditary bundle branch system defect	2	ORPHANET
Tgene		C0033578	Prostatic Neoplasms	1	CTD_human
Tgene		C0265961	Erythrokeratodermia variabilis	1	ORPHANET
Tgene		C0376358	Malignant neoplasm of prostate	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ACPP-TRPM4 (FusionGDB2 ID:HG55TG54795)

Fusion Gene Summary for ACPP-TRPM4

Fusion Gene ORF analysis for ACPP-TRPM4

Fusion Genomic Features for ACPP-TRPM4

Fusion Protein Features for ACPP-TRPM4

Fusion Gene Sequence for ACPP-TRPM4

Fusion Gene PPI Analysis for ACPP-TRPM4

Related Drugs for ACPP-TRPM4

Related Diseases for ACPP-TRPM4

Fusion Gene Studies
in Kim Lab