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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACPP-TRPM4 (FusionGDB2 ID:HG55TG54795)

Fusion Gene Summary for ACPP-TRPM4

check button Fusion gene summary
Fusion gene informationFusion gene name: ACPP-TRPM4
Fusion gene ID: hg55tg54795
HgeneTgene
Gene symbol

ACPP

TRPM4

Gene ID

55

54795

Gene nameacid phosphatase 3transient receptor potential cation channel subfamily M member 4
Synonyms5'-NT|ACP-3|ACPP|TM-PAPEKVP6|LTrpC4|PFHB1B|TRPM4B|hTRPM4
Cytomap('ACPP')('TRPM4')

3q22.1

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionprostatic acid phosphataseTMPaseacid phosphatase, prostateecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatasetransient receptor potential cation channel subfamily M member 4calcium-activated non-selective cation channel 1long transient receptor potential channel 4melastatin-4
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336375, ENST00000351273, 
ENST00000475741, ENST00000489084, 
Fusion gene scores* DoF score28 X 17 X 4=190410 X 9 X 4=360
# samples 3113
** MAII scorelog2(31/1904*10)=-2.61869335803371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACPP [Title/Abstract] AND TRPM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACPP(132075699)-TRPM4(49705220), # samples:1
Anticipated loss of major functional domain due to fusion event.ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACPP-TRPM4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACPP-TRPM4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACPP

GO:0046085

adenosine metabolic process

18940592

TgeneTRPM4

GO:0002724

regulation of T cell cytokine production

20656926

TgeneTRPM4

GO:0008284

positive regulation of cell proliferation

20625999

TgeneTRPM4

GO:0016925

protein sumoylation

19726882

TgeneTRPM4

GO:0019722

calcium-mediated signaling

27207958

TgeneTRPM4

GO:0051289

protein homotetramerization

29211723|29217581

TgeneTRPM4

GO:0090263

positive regulation of canonical Wnt signaling pathway

20625999

TgeneTRPM4

GO:0098662

inorganic cation transmembrane transport

29211723

TgeneTRPM4

GO:0098719

sodium ion import across plasma membrane

27207958


check buttonFusion gene breakpoints across ACPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TRPM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A65MACPPchr3

132075699

+TRPM4chr19

49705220

+


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Fusion Gene ORF analysis for ACPP-TRPM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336375ENST00000601347ACPPchr3

132075699

+TRPM4chr19

49705220

+
5CDS-intronENST00000351273ENST00000601347ACPPchr3

132075699

+TRPM4chr19

49705220

+
5CDS-intronENST00000475741ENST00000601347ACPPchr3

132075699

+TRPM4chr19

49705220

+
Frame-shiftENST00000336375ENST00000252826ACPPchr3

132075699

+TRPM4chr19

49705220

+
Frame-shiftENST00000336375ENST00000355712ACPPchr3

132075699

+TRPM4chr19

49705220

+
Frame-shiftENST00000336375ENST00000427978ACPPchr3

132075699

+TRPM4chr19

49705220

+
Frame-shiftENST00000475741ENST00000252826ACPPchr3

132075699

+TRPM4chr19

49705220

+
Frame-shiftENST00000475741ENST00000355712ACPPchr3

132075699

+TRPM4chr19

49705220

+
Frame-shiftENST00000475741ENST00000427978ACPPchr3

132075699

+TRPM4chr19

49705220

+
In-frameENST00000351273ENST00000252826ACPPchr3

132075699

+TRPM4chr19

49705220

+
In-frameENST00000351273ENST00000355712ACPPchr3

132075699

+TRPM4chr19

49705220

+
In-frameENST00000351273ENST00000427978ACPPchr3

132075699

+TRPM4chr19

49705220

+
intron-3CDSENST00000489084ENST00000252826ACPPchr3

132075699

+TRPM4chr19

49705220

+
intron-3CDSENST00000489084ENST00000355712ACPPchr3

132075699

+TRPM4chr19

49705220

+
intron-3CDSENST00000489084ENST00000427978ACPPchr3

132075699

+TRPM4chr19

49705220

+
intron-intronENST00000489084ENST00000601347ACPPchr3

132075699

+TRPM4chr19

49705220

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000351273ACPPchr3132075699+ENST00000252826TRPM4chr1949705220+22181188261879617
ENST00000351273ACPPchr3132075699+ENST00000427978TRPM4chr1949705220+20621188261879617
ENST00000351273ACPPchr3132075699+ENST00000355712TRPM4chr1949705220+22161188261879617

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000351273ENST00000252826ACPPchr3132075699+TRPM4chr1949705220+0.0045121680.99548787
ENST00000351273ENST00000427978ACPPchr3132075699+TRPM4chr1949705220+0.0053438440.9946562
ENST00000351273ENST00000355712ACPPchr3132075699+TRPM4chr1949705220+0.0045473480.9954527

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Fusion Genomic Features for ACPP-TRPM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACPPchr3132075699+TRPM4chr1949705220+4.72E-060.99999523
ACPPchr3132075699+TRPM4chr1949705220+4.72E-060.99999523

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACPP-TRPM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132075699/chr19:49705220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRPM4chr3:132075699chr19:49705220ENST0000025282618251134_11879841215.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM4chr3:132075699chr19:49705220ENST0000042797817241134_11878391070.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724964_9848391070.0IntramembranePore-forming
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724975_9778391070.0MotifSelectivity filter
TgeneTRPM4chr3:132075699chr19:49705220ENST0000025282618251076_11769841215.0RegionNote=Calmodulin-binding
TgeneTRPM4chr3:132075699chr19:49705220ENST0000042797817241076_11768391070.0RegionNote=Calmodulin-binding
TgeneTRPM4chr3:132075699chr19:49705220ENST0000025282618251041_12149841215.0Topological domainCytoplasmic
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825985_10199841215.0Topological domainExtracellular
TgeneTRPM4chr3:132075699chr19:49705220ENST0000042797817241041_12148391070.0Topological domainCytoplasmic
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724885_8868391070.0Topological domainExtracellular
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724911_9308391070.0Topological domainCytoplasmic
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724952_9638391070.0Topological domainExtracellular
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724985_10198391070.0Topological domainExtracellular
TgeneTRPM4chr3:132075699chr19:49705220ENST0000025282618251020_10409841215.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST0000042797817241020_10408391070.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724864_8848391070.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724887_9108391070.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724931_9518391070.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825964_9849841215.0IntramembranePore-forming
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825975_9779841215.0MotifSelectivity filter
TgeneTRPM4chr3:132075699chr19:49705220ENST0000025282618251_7829841215.0Topological domainCytoplasmic
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825804_8149841215.0Topological domainExtracellular
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825836_8639841215.0Topological domainCytoplasmic
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825885_8869841215.0Topological domainExtracellular
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825911_9309841215.0Topological domainCytoplasmic
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825952_9639841215.0Topological domainExtracellular
TgeneTRPM4chr3:132075699chr19:49705220ENST0000042797817241_7828391070.0Topological domainCytoplasmic
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724804_8148391070.0Topological domainExtracellular
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724836_8638391070.0Topological domainCytoplasmic
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825783_8039841215.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825815_8359841215.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825864_8849841215.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825887_9109841215.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST000002528261825931_9519841215.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724783_8038391070.0TransmembraneHelical
TgeneTRPM4chr3:132075699chr19:49705220ENST000004279781724815_8358391070.0TransmembraneHelical


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Fusion Gene Sequence for ACPP-TRPM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1471_1471_1_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000252826_length(transcript)=2218nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGGCCCTCATGGAGCACAGCAACTGCTCGTCGGAGCCCGGCTTCTGGGCACACCCTCCTGGGGCCCAGGCGG
GCACCTGCGTCTCCCAGTATGCCAACTGGCTGGTGGTGCTGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGC
TCATTGCCATGTTCAGTTACACATTCGGCAAAGTACAGGGCAACAGCGATCTCTACTGGAAGGCGCAGCGTTACCGCCTCATCCGGGAAT
TCCACTCTCGGCCCGCGCTGGCCCCGCCCTTTATCGTCATCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCC
CCCAGCCGTCCTCCCCGGCCCTCGAGCATTTCCGGGTTTACCTTTCTAAGGAAGCCGAGCGGAAGCTGCTAACGTGGGAATCGGTGCATA
AGGAGAACTTTCTGCTGGCACGCGCTAGGGACAAGCGGGAGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAAGGTGGACTTGGCAC
TGAAACAGCTGGGACACATCCGCGAGTACGAACAGCGCCTGAAAGTGCTGGAGCGGGAGGTCCAGCAGTGTAGCCGCGTCCTGGGGTGGG
TGGCCGAGGCCCTGAGCCGCTCTGCCTTGCTGCCCCCAGGTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAGACTGAGCCCTGCTGG
CGGACTTCAAGGAGAAGCCCCCACAGGGGATTTTGCTCCTAGAGTAAGGCTCATCTGGGCCTCGGCCCCCGCACCTGGTGGCCTTGTCCT
TGAGGTGAGCCCCATGTCCATCTGGGCCACTGTCAGGACCACCTTTGGGAGTGTCATCCTTACAAACCACAGCATGCCCGGCTCCTCCCA
GAACCAGTCCCAGCCTGGGAGGATCAAGGCCTGGATCCCGGGCCGTTATCCATCTGGAGGCTGCAGGGTCCTTGGGGTAACAGGGACCAC

>1471_1471_1_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000252826_length(amino acids)=617AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTF
GKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARA

--------------------------------------------------------------
>1471_1471_2_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000355712_length(transcript)=2216nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGGCCCTCATGGAGCACAGCAACTGCTCGTCGGAGCCCGGCTTCTGGGCACACCCTCCTGGGGCCCAGGCGG
GCACCTGCGTCTCCCAGTATGCCAACTGGCTGGTGGTGCTGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGC
TCATTGCCATGTTCAGTTACACATTCGGCAAAGTACAGGGCAACAGCGATCTCTACTGGAAGGCGCAGCGTTACCGCCTCATCCGGGAAT
TCCACTCTCGGCCCGCGCTGGCCCCGCCCTTTATCGTCATCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCC
CCCAGCCGTCCTCCCCGGCCCTCGAGCATTTCCGGGTTTACCTTTCTAAGGAAGCCGAGCGGAAGCTGCTAACGTGGGAATCGGTGCATA
AGGAGAACTTTCTGCTGGCACGCGCTAGGGACAAGCGGGAGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAAGGTGGACTTGGCAC
TGAAACAGCTGGGACACATCCGCGAGTACGAACAGCGCCTGAAAGTGCTGGAGCGGGAGGTCCAGCAGTGTAGCCGCGTCCTGGGGTGGG
TGGCCGAGGCCCTGAGCCGCTCTGCCTTGCTGCCCCCAGGTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAGACTGAGCCCTGCTGG
CGGACTTCAAGGAGAAGCCCCCACAGGGGATTTTGCTCCTAGAGTAAGGCTCATCTGGGCCTCGGCCCCCGCACCTGGTGGCCTTGTCCT
TGAGGTGAGCCCCATGTCCATCTGGGCCACTGTCAGGACCACCTTTGGGAGTGTCATCCTTACAAACCACAGCATGCCCGGCTCCTCCCA
GAACCAGTCCCAGCCTGGGAGGATCAAGGCCTGGATCCCGGGCCGTTATCCATCTGGAGGCTGCAGGGTCCTTGGGGTAACAGGGACCAC

>1471_1471_2_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000355712_length(amino acids)=617AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTF
GKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARA

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>1471_1471_3_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000427978_length(transcript)=2062nt_BP=1188nt
GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC
TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC
ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG
GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA
TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC
CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT
TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC
TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC
CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG
AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA
TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC
ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC
TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA
CCACAAACAGCCATCAAGTGGCCCTCATGGAGCACAGCAACTGCTCGTCGGAGCCCGGCTTCTGGGCACACCCTCCTGGGGCCCAGGCGG
GCACCTGCGTCTCCCAGTATGCCAACTGGCTGGTGGTGCTGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGC
TCATTGCCATGTTCAGTTACACATTCGGCAAAGTACAGGGCAACAGCGATCTCTACTGGAAGGCGCAGCGTTACCGCCTCATCCGGGAAT
TCCACTCTCGGCCCGCGCTGGCCCCGCCCTTTATCGTCATCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCC
CCCAGCCGTCCTCCCCGGCCCTCGAGCATTTCCGGGTTTACCTTTCTAAGGAAGCCGAGCGGAAGCTGCTAACGTGGGAATCGGTGCATA
AGGAGAACTTTCTGCTGGCACGCGCTAGGGACAAGCGGGAGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAAGGTGGACTTGGCAC
TGAAACAGCTGGGACACATCCGCGAGTACGAACAGCGCCTGAAAGTGCTGGAGCGGGAGGTCCAGCAGTGTAGCCGCGTCCTGGGGTGGG
TGGCCGAGGCCCTGAGCCGCTCTGCCTTGCTGCCCCCAGGTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAGACTGAGCCCTGCTGG
CGGACTTCAAGGAGAAGCCCCCACAGGGGATTTTGCTCCTAGAGTAAGGCTCATCTGGGCCTCGGCCCCCGCACCTGGTGGCCTTGTCCT

>1471_1471_3_ACPP-TRPM4_ACPP_chr3_132075699_ENST00000351273_TRPM4_chr19_49705220_ENST00000427978_length(amino acids)=617AA_BP=387
MPETALLNMRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELG
EYIRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETL
KSEEFQKRLHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGV
LVNEILNHMKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCP
LERFAELVGPVIPQDWSTECMTTNSHQVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTF
GKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARA

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Fusion Gene PPI Analysis for ACPP-TRPM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACPP-TRPM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACPP-TRPM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1142166Brugada Syndrome (disorder)7CLINGEN;ORPHANET
TgeneC1970298Progressive Familial Heart Block, Type Ib6CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1879286Hereditary bundle branch system defect2ORPHANET
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0265961Erythrokeratodermia variabilis1ORPHANET
TgeneC0376358Malignant neoplasm of prostate1CTD_human