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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLDND1-ARPP21 (FusionGDB2 ID:HG56650TG10777)

Fusion Gene Summary for CLDND1-ARPP21

check button Fusion gene summary
Fusion gene informationFusion gene name: CLDND1-ARPP21
Fusion gene ID: hg56650tg10777
HgeneTgene
Gene symbol

CLDND1

ARPP21

Gene ID

56650

10777

Gene nameclaudin domain containing 1cAMP regulated phosphoprotein 21
SynonymsC3orf4|GENX-3745|Z38ARPP-21|R3HDM3|RCS|TARPP
Cytomap('CLDND1')('ARPP21')

3q11.2

3p22.3

Type of geneprotein-codingprotein-coding
Descriptionclaudin domain-containing protein 1claudin domain containing 1 proteinmembrane protein GENX-3745cAMP-regulated phosphoprotein 21R3H domain containing 3cAMP regulated phosphoprotein 21kDacyclic AMP-regulated phosphoprotein, 21 kDthymocyte cAMP-regulated phosphoprotein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000437922, ENST00000502288, 
ENST00000511081, ENST00000341181, 
ENST00000394180, ENST00000394181, 
ENST00000394185, ENST00000507874, 
ENST00000508503, ENST00000510545, 
ENST00000503004, ENST00000513287, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 3 X 2=12
# samples 53
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLDND1 [Title/Abstract] AND ARPP21 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLDND1(98241693)-ARPP21(35721279), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-TS-A7P3-01ACLDND1chr3

98241693

-ARPP21chr3

35721279

+
ChimerDB4MESOTCGA-TS-A7P3CLDND1chr3

98241692

-ARPP21chr3

35721278

+


Top

Fusion Gene ORF analysis for CLDND1-ARPP21

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000437922ENST00000187397CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000187397CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000337271CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000337271CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000396482CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000396482CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000412048CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000412048CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000417925CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000417925CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000427542CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000427542CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000428373CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000428373CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000432682CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000432682CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000444190CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000444190CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000458225CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000458225CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000437922ENST00000474696CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000437922ENST00000474696CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000187397CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000187397CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000337271CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000337271CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000396482CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000396482CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000412048CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000412048CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000417925CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000417925CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000427542CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000427542CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000428373CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000428373CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000432682CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000432682CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000444190CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000444190CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000458225CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000458225CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000502288ENST00000474696CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000502288ENST00000474696CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000187397CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000187397CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000337271CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000337271CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000396482CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000396482CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000412048CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000412048CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000417925CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000417925CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000427542CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000427542CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000428373CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000428373CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000432682CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000432682CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000444190CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000444190CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000458225CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000458225CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-5UTRENST00000511081ENST00000474696CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-5UTRENST00000511081ENST00000474696CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000437922ENST00000396481CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000437922ENST00000396481CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000437922ENST00000436702CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000437922ENST00000436702CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000437922ENST00000438071CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000437922ENST00000438071CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000437922ENST00000441454CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000437922ENST00000441454CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000437922ENST00000476052CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000437922ENST00000476052CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000502288ENST00000396481CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000502288ENST00000396481CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000502288ENST00000436702CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000502288ENST00000436702CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000502288ENST00000438071CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000502288ENST00000438071CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000502288ENST00000441454CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000502288ENST00000441454CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000502288ENST00000476052CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000502288ENST00000476052CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000511081ENST00000396481CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000511081ENST00000396481CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000511081ENST00000436702CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000511081ENST00000436702CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000511081ENST00000438071CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000511081ENST00000438071CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000511081ENST00000441454CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000511081ENST00000441454CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5CDS-intronENST00000511081ENST00000476052CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5CDS-intronENST00000511081ENST00000476052CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000187397CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000187397CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000337271CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000337271CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000396482CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000396482CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000412048CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000412048CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000417925CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000417925CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000427542CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000427542CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000428373CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000428373CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000432682CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000432682CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000444190CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000444190CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000458225CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000458225CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000341181ENST00000474696CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000341181ENST00000474696CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000187397CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000187397CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000337271CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000337271CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000396482CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000396482CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000412048CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000412048CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000417925CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000417925CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000427542CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000427542CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000428373CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000428373CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000432682CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000432682CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000444190CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000444190CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000458225CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000458225CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394180ENST00000474696CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394180ENST00000474696CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394181ENST00000187397CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394181ENST00000187397CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394181ENST00000337271CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394181ENST00000337271CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394181ENST00000396482CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394181ENST00000396482CLDND1chr3

98241692

-ARPP21chr3

35721278

+
5UTR-5UTRENST00000394181ENST00000412048CLDND1chr3

98241693

-ARPP21chr3

35721279

+
5UTR-5UTRENST00000394181ENST00000412048CLDND1chr3

98241692

-ARPP21chr3

35721278

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5UTR-5UTRENST00000394181ENST00000417925CLDND1chr3

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5UTR-5UTRENST00000394181ENST00000428373CLDND1chr3

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5UTR-5UTRENST00000394181ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000394181ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000394181ENST00000444190CLDND1chr3

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5UTR-5UTRENST00000394181ENST00000444190CLDND1chr3

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5UTR-5UTRENST00000394181ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000394181ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000394181ENST00000474696CLDND1chr3

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5UTR-5UTRENST00000394181ENST00000474696CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000187397CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000187397CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000337271CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000337271CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000396482CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000396482CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000412048CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000412048CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000417925CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000417925CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000427542CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000427542CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000428373CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000428373CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000444190CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000444190CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000474696CLDND1chr3

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5UTR-5UTRENST00000394185ENST00000474696CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000187397CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000187397CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000337271CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000337271CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000396482CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000396482CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000412048CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000412048CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000417925CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000417925CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000427542CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000427542CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000428373CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000428373CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000444190CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000444190CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000474696CLDND1chr3

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5UTR-5UTRENST00000507874ENST00000474696CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000187397CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000187397CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000337271CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000337271CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000396482CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000396482CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000412048CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000412048CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000417925CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000417925CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000427542CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000427542CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000428373CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000428373CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000444190CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000444190CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000474696CLDND1chr3

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5UTR-5UTRENST00000508503ENST00000474696CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000187397CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000187397CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000337271CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000337271CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000396482CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000396482CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000412048CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000412048CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000417925CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000417925CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000427542CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000427542CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000428373CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000428373CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000432682CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000444190CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000458225CLDND1chr3

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5UTR-5UTRENST00000510545ENST00000474696CLDND1chr3

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5UTR-intronENST00000341181ENST00000396481CLDND1chr3

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5UTR-intronENST00000341181ENST00000396481CLDND1chr3

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5UTR-intronENST00000341181ENST00000436702CLDND1chr3

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5UTR-intronENST00000341181ENST00000436702CLDND1chr3

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5UTR-intronENST00000341181ENST00000438071CLDND1chr3

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5UTR-intronENST00000341181ENST00000438071CLDND1chr3

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5UTR-intronENST00000341181ENST00000441454CLDND1chr3

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5UTR-intronENST00000341181ENST00000441454CLDND1chr3

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5UTR-intronENST00000341181ENST00000476052CLDND1chr3

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5UTR-intronENST00000341181ENST00000476052CLDND1chr3

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5UTR-intronENST00000394180ENST00000396481CLDND1chr3

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5UTR-intronENST00000394180ENST00000396481CLDND1chr3

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5UTR-intronENST00000394180ENST00000436702CLDND1chr3

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5UTR-intronENST00000394180ENST00000436702CLDND1chr3

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5UTR-intronENST00000394180ENST00000438071CLDND1chr3

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5UTR-intronENST00000394180ENST00000438071CLDND1chr3

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5UTR-intronENST00000394180ENST00000441454CLDND1chr3

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5UTR-intronENST00000394180ENST00000441454CLDND1chr3

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5UTR-intronENST00000394180ENST00000476052CLDND1chr3

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5UTR-intronENST00000394180ENST00000476052CLDND1chr3

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5UTR-intronENST00000394181ENST00000396481CLDND1chr3

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5UTR-intronENST00000394181ENST00000396481CLDND1chr3

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5UTR-intronENST00000394181ENST00000436702CLDND1chr3

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5UTR-intronENST00000394181ENST00000436702CLDND1chr3

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5UTR-intronENST00000394181ENST00000438071CLDND1chr3

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5UTR-intronENST00000394181ENST00000438071CLDND1chr3

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5UTR-intronENST00000394181ENST00000441454CLDND1chr3

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5UTR-intronENST00000394181ENST00000441454CLDND1chr3

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5UTR-intronENST00000394181ENST00000476052CLDND1chr3

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5UTR-intronENST00000394181ENST00000476052CLDND1chr3

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5UTR-intronENST00000394185ENST00000396481CLDND1chr3

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5UTR-intronENST00000394185ENST00000396481CLDND1chr3

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5UTR-intronENST00000394185ENST00000436702CLDND1chr3

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5UTR-intronENST00000394185ENST00000436702CLDND1chr3

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5UTR-intronENST00000394185ENST00000438071CLDND1chr3

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5UTR-intronENST00000394185ENST00000438071CLDND1chr3

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5UTR-intronENST00000394185ENST00000441454CLDND1chr3

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5UTR-intronENST00000394185ENST00000441454CLDND1chr3

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5UTR-intronENST00000394185ENST00000476052CLDND1chr3

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5UTR-intronENST00000394185ENST00000476052CLDND1chr3

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5UTR-intronENST00000507874ENST00000396481CLDND1chr3

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5UTR-intronENST00000507874ENST00000436702CLDND1chr3

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5UTR-intronENST00000507874ENST00000436702CLDND1chr3

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5UTR-intronENST00000507874ENST00000438071CLDND1chr3

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5UTR-intronENST00000507874ENST00000438071CLDND1chr3

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5UTR-intronENST00000507874ENST00000441454CLDND1chr3

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5UTR-intronENST00000507874ENST00000441454CLDND1chr3

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5UTR-intronENST00000507874ENST00000476052CLDND1chr3

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5UTR-intronENST00000507874ENST00000476052CLDND1chr3

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5UTR-intronENST00000508503ENST00000396481CLDND1chr3

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5UTR-intronENST00000508503ENST00000396481CLDND1chr3

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5UTR-intronENST00000508503ENST00000436702CLDND1chr3

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5UTR-intronENST00000508503ENST00000436702CLDND1chr3

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5UTR-intronENST00000508503ENST00000438071CLDND1chr3

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5UTR-intronENST00000508503ENST00000438071CLDND1chr3

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5UTR-intronENST00000508503ENST00000441454CLDND1chr3

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5UTR-intronENST00000508503ENST00000441454CLDND1chr3

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5UTR-intronENST00000508503ENST00000476052CLDND1chr3

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5UTR-intronENST00000508503ENST00000476052CLDND1chr3

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5UTR-intronENST00000510545ENST00000396481CLDND1chr3

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5UTR-intronENST00000510545ENST00000396481CLDND1chr3

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5UTR-intronENST00000510545ENST00000436702CLDND1chr3

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5UTR-intronENST00000510545ENST00000436702CLDND1chr3

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5UTR-intronENST00000510545ENST00000438071CLDND1chr3

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5UTR-intronENST00000510545ENST00000438071CLDND1chr3

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5UTR-intronENST00000510545ENST00000441454CLDND1chr3

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5UTR-intronENST00000510545ENST00000441454CLDND1chr3

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5UTR-intronENST00000510545ENST00000476052CLDND1chr3

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5UTR-intronENST00000510545ENST00000476052CLDND1chr3

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intron-5UTRENST00000503004ENST00000187397CLDND1chr3

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intron-5UTRENST00000503004ENST00000187397CLDND1chr3

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intron-5UTRENST00000503004ENST00000337271CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000337271CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000503004ENST00000396482CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000396482CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000503004ENST00000412048CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000412048CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000503004ENST00000417925CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000417925CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000503004ENST00000427542CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000427542CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000503004ENST00000428373CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000428373CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000503004ENST00000432682CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000432682CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000503004ENST00000444190CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000444190CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000503004ENST00000458225CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000458225CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000503004ENST00000474696CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000503004ENST00000474696CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000187397CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000187397CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000337271CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000337271CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000396482CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000396482CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000412048CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000412048CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000417925CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000417925CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000427542CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000427542CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000428373CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000428373CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000432682CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000432682CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000444190CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000444190CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000458225CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000458225CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-5UTRENST00000513287ENST00000474696CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-5UTRENST00000513287ENST00000474696CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000503004ENST00000396481CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000503004ENST00000396481CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000503004ENST00000436702CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000503004ENST00000436702CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000503004ENST00000438071CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000503004ENST00000438071CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000503004ENST00000441454CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000503004ENST00000441454CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000503004ENST00000476052CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000503004ENST00000476052CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000513287ENST00000396481CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000513287ENST00000396481CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000513287ENST00000436702CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000513287ENST00000436702CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000513287ENST00000438071CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000513287ENST00000438071CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000513287ENST00000441454CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000513287ENST00000441454CLDND1chr3

98241692

-ARPP21chr3

35721278

+
intron-intronENST00000513287ENST00000476052CLDND1chr3

98241693

-ARPP21chr3

35721279

+
intron-intronENST00000513287ENST00000476052CLDND1chr3

98241692

-ARPP21chr3

35721278

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CLDND1-ARPP21


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CLDND1chr398241692-ARPP21chr335721276+0.0028320110.997168
CLDND1chr398241692-ARPP21chr335721276+0.0028320110.997168
CLDND1chr398241692-ARPP21chr335721276+0.0028320110.997168
CLDND1chr398241692-ARPP21chr335721276+0.0028320110.997168


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CLDND1-ARPP21


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:98241693/:35721279)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CLDND1-ARPP21


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CLDND1-ARPP21


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLDND1-ARPP21


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLDND1-ARPP21


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource