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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPHK2-CGB7 (FusionGDB2 ID:HG56848TG94027)

Fusion Gene Summary for SPHK2-CGB7

check button Fusion gene summary
Fusion gene informationFusion gene name: SPHK2-CGB7
Fusion gene ID: hg56848tg94027
HgeneTgene
Gene symbol

SPHK2

CGB7

Gene ID

56848

94027

Gene namesphingosine kinase 2chorionic gonadotropin subunit beta 7
SynonymsSK 2|SK-2|SPK 2|SPK-2CG-beta-a|CGB6
Cytomap('SPHK2')('CGB7')

19q13.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionsphingosine kinase 2sphingosine kinase type 2choriogonadotropin subunit beta 7chorionic gonadotropin beta 7 subunitchorionic gonadotropin beta subunit 7chorionic gonadotropin, beta polypeptide 7
Modification date2020031320200313
UniProtAcc.

P0DN87

Ensembl transtripts involved in fusion geneENST00000245222, ENST00000598088, 
ENST00000600537, ENST00000340932, 
ENST00000601712, ENST00000443164, 
ENST00000599029, ENST00000599033, 
ENST00000599748, 
Fusion gene scores* DoF score4 X 2 X 3=241 X 1 X 1=1
# samples 31
** MAII scorelog2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: SPHK2 [Title/Abstract] AND CGB7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPHK2(49123810)-CGB7(49558265), # samples:2
Anticipated loss of major functional domain due to fusion event.SPHK2-CGB7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPHK2-CGB7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPHK2

GO:0006669

sphinganine-1-phosphate biosynthetic process

10751414|19729656

HgeneSPHK2

GO:0031064

negative regulation of histone deacetylation

19729656

HgeneSPHK2

GO:0043065

positive regulation of apoptotic process

16118219

HgeneSPHK2

GO:0043977

histone H2A-K5 acetylation

19729656

HgeneSPHK2

GO:0043980

histone H2B-K12 acetylation

19729656

HgeneSPHK2

GO:0045815

positive regulation of gene expression, epigenetic

19729656

HgeneSPHK2

GO:1901726

negative regulation of histone deacetylase activity

19729656

HgeneSPHK2

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

17635916

HgeneSPHK2

GO:2000304

positive regulation of ceramide biosynthetic process

16118219

HgeneSPHK2

GO:2000617

positive regulation of histone H3-K9 acetylation

19729656


check buttonFusion gene breakpoints across SPHK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CGB7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0D0-01ASPHK2chr19

49123810

+CGB7chr19

49558265

-


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Fusion Gene ORF analysis for SPHK2-CGB7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000245222ENST00000593309SPHK2chr19

49123810

+CGB7chr19

49558265

-
5CDS-intronENST00000598088ENST00000593309SPHK2chr19

49123810

+CGB7chr19

49558265

-
5CDS-intronENST00000600537ENST00000593309SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-3CDSENST00000340932ENST00000356213SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-3CDSENST00000340932ENST00000377280SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-3CDSENST00000340932ENST00000596965SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-3CDSENST00000340932ENST00000597853SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-3CDSENST00000601712ENST00000356213SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-3CDSENST00000601712ENST00000377280SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-3CDSENST00000601712ENST00000596965SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-3CDSENST00000601712ENST00000597853SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-intronENST00000340932ENST00000593309SPHK2chr19

49123810

+CGB7chr19

49558265

-
5UTR-intronENST00000601712ENST00000593309SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000245222ENST00000356213SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000245222ENST00000377280SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000245222ENST00000596965SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000245222ENST00000597853SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000598088ENST00000356213SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000598088ENST00000377280SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000598088ENST00000596965SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000598088ENST00000597853SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000600537ENST00000356213SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000600537ENST00000377280SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000600537ENST00000596965SPHK2chr19

49123810

+CGB7chr19

49558265

-
In-frameENST00000600537ENST00000597853SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000443164ENST00000356213SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000443164ENST00000377280SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000443164ENST00000596965SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000443164ENST00000597853SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599029ENST00000356213SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599029ENST00000377280SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599029ENST00000596965SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599029ENST00000597853SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599033ENST00000356213SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599033ENST00000377280SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599033ENST00000596965SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599033ENST00000597853SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599748ENST00000356213SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599748ENST00000377280SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599748ENST00000596965SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-3CDSENST00000599748ENST00000597853SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-intronENST00000443164ENST00000593309SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-intronENST00000599029ENST00000593309SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-intronENST00000599033ENST00000593309SPHK2chr19

49123810

+CGB7chr19

49558265

-
intron-intronENST00000599748ENST00000593309SPHK2chr19

49123810

+CGB7chr19

49558265

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000245222SPHK2chr1949123810+ENST00000377280CGB7chr1949558265-905405366887173
ENST00000245222SPHK2chr1949123810+ENST00000596965CGB7chr1949558265-904405797213194
ENST00000245222SPHK2chr1949123810+ENST00000356213CGB7chr1949558265-904405797213194
ENST00000245222SPHK2chr1949123810+ENST00000597853CGB7chr1949558265-904405797213194
ENST00000600537SPHK2chr1949123810+ENST00000377280CGB7chr1949558265-744244205726173
ENST00000600537SPHK2chr1949123810+ENST00000596965CGB7chr1949558265-74324463652194
ENST00000600537SPHK2chr1949123810+ENST00000356213CGB7chr1949558265-74324463652194
ENST00000600537SPHK2chr1949123810+ENST00000597853CGB7chr1949558265-74324463652194
ENST00000598088SPHK2chr1949123810+ENST00000377280CGB7chr1949558265-808308269790173
ENST00000598088SPHK2chr1949123810+ENST00000596965CGB7chr1949558265-8073087002233
ENST00000598088SPHK2chr1949123810+ENST00000356213CGB7chr1949558265-8073087002233
ENST00000598088SPHK2chr1949123810+ENST00000597853CGB7chr1949558265-8073087002233

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000245222ENST00000377280SPHK2chr1949123810+CGB7chr1949558265-0.0614435080.93855655
ENST00000245222ENST00000596965SPHK2chr1949123810+CGB7chr1949558265-0.0583683740.9416316
ENST00000245222ENST00000356213SPHK2chr1949123810+CGB7chr1949558265-0.0583683740.9416316
ENST00000245222ENST00000597853SPHK2chr1949123810+CGB7chr1949558265-0.0583683740.9416316
ENST00000600537ENST00000377280SPHK2chr1949123810+CGB7chr1949558265-0.0509973880.9490026
ENST00000600537ENST00000596965SPHK2chr1949123810+CGB7chr1949558265-0.0483012530.9516988
ENST00000600537ENST00000356213SPHK2chr1949123810+CGB7chr1949558265-0.0483012530.9516988
ENST00000600537ENST00000597853SPHK2chr1949123810+CGB7chr1949558265-0.0483012530.9516988
ENST00000598088ENST00000377280SPHK2chr1949123810+CGB7chr1949558265-0.12291590.87708414
ENST00000598088ENST00000596965SPHK2chr1949123810+CGB7chr1949558265-0.1192549240.88074505
ENST00000598088ENST00000356213SPHK2chr1949123810+CGB7chr1949558265-0.1192549240.88074505
ENST00000598088ENST00000597853SPHK2chr1949123810+CGB7chr1949558265-0.1192549240.88074505

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Fusion Genomic Features for SPHK2-CGB7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for SPHK2-CGB7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49123810/chr19:49558265)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CGB7

P0DN87

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPHK2chr19:49123810chr19:49558265ENST00000245222+27178_32513655.0DomainDAGKc
HgeneSPHK2chr19:49123810chr19:49558265ENST00000443164+16178_3250762.0DomainDAGKc
HgeneSPHK2chr19:49123810chr19:49558265ENST00000598088+27178_32513655.0DomainDAGKc
HgeneSPHK2chr19:49123810chr19:49558265ENST00000599748+16178_3250619.0DomainDAGKc
HgeneSPHK2chr19:49123810chr19:49558265ENST00000600537+27178_32513596.0DomainDAGKc
HgeneSPHK2chr19:49123810chr19:49558265ENST00000245222+27122_13013655.0MotifNLS
HgeneSPHK2chr19:49123810chr19:49558265ENST00000245222+27416_42513655.0MotifNES
HgeneSPHK2chr19:49123810chr19:49558265ENST00000443164+16122_1300762.0MotifNLS
HgeneSPHK2chr19:49123810chr19:49558265ENST00000443164+16416_4250762.0MotifNES
HgeneSPHK2chr19:49123810chr19:49558265ENST00000598088+27122_13013655.0MotifNLS
HgeneSPHK2chr19:49123810chr19:49558265ENST00000598088+27416_42513655.0MotifNES
HgeneSPHK2chr19:49123810chr19:49558265ENST00000599748+16122_1300619.0MotifNLS
HgeneSPHK2chr19:49123810chr19:49558265ENST00000599748+16416_4250619.0MotifNES
HgeneSPHK2chr19:49123810chr19:49558265ENST00000600537+27122_13013596.0MotifNLS
HgeneSPHK2chr19:49123810chr19:49558265ENST00000600537+27416_42513596.0MotifNES
HgeneSPHK2chr19:49123810chr19:49558265ENST00000245222+27188_19013655.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000245222+27220_22413655.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000245222+27277_27913655.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000245222+27622_62413655.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000443164+16188_1900762.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000443164+16220_2240762.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000443164+16277_2790762.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000443164+16622_6240762.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000598088+27188_19013655.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000598088+27220_22413655.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000598088+27277_27913655.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000598088+27622_62413655.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000599748+16188_1900619.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000599748+16220_2240619.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000599748+16277_2790619.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000599748+16622_6240619.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000600537+27188_19013596.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000600537+27220_22413596.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000600537+27277_27913596.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000600537+27622_62413596.0Nucleotide bindingATP
HgeneSPHK2chr19:49123810chr19:49558265ENST00000245222+271_17513655.0RegionNote=Required for binding to sulfatide and phosphoinositides and for membrane localization
HgeneSPHK2chr19:49123810chr19:49558265ENST00000245222+27245_24813655.0RegionSubstrate binding
HgeneSPHK2chr19:49123810chr19:49558265ENST00000443164+161_1750762.0RegionNote=Required for binding to sulfatide and phosphoinositides and for membrane localization
HgeneSPHK2chr19:49123810chr19:49558265ENST00000443164+16245_2480762.0RegionSubstrate binding
HgeneSPHK2chr19:49123810chr19:49558265ENST00000598088+271_17513655.0RegionNote=Required for binding to sulfatide and phosphoinositides and for membrane localization
HgeneSPHK2chr19:49123810chr19:49558265ENST00000598088+27245_24813655.0RegionSubstrate binding
HgeneSPHK2chr19:49123810chr19:49558265ENST00000599748+161_1750619.0RegionNote=Required for binding to sulfatide and phosphoinositides and for membrane localization
HgeneSPHK2chr19:49123810chr19:49558265ENST00000599748+16245_2480619.0RegionSubstrate binding
HgeneSPHK2chr19:49123810chr19:49558265ENST00000600537+271_17513596.0RegionNote=Required for binding to sulfatide and phosphoinositides and for membrane localization
HgeneSPHK2chr19:49123810chr19:49558265ENST00000600537+27245_24813596.0RegionSubstrate binding


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Fusion Gene Sequence for SPHK2-CGB7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>85769_85769_1_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000245222_CGB7_chr19_49558265_ENST00000356213_length(transcript)=904nt_BP=405nt
CGACTGACTAGCCGGGCGATAACGGCAGAGAGCATAGAGCGCAGGAACAAGCGCAACGTCCAAGAGGGAAGGGCCAGCACGTCGGGGGCC
TCTCTGGCCCTACCCAGGCCGTGTTCTCGATAGCTTTCCGGAAGAAAGGGATCTGGGAGCGAGATGCGTGTAGCTAGCACGATGCGTCGC
GCGGTGACGCTCTGGCCCGACGCCGACGGCCTCTCAGTGGCTCCCGGAGGACCCGGCGGGCCCAGTGTTGGAGAGCTGAAGGTCAGGCCA
GGACAGTGAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTGATGTAACAGAGCAGAGGAC
CAGCAGATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAGCATGGGCGGGACATGGGCA
TCCAGGGAGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCCCGTGTGCATCACCGTCAAC
ACCACCATCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCAGGTGGTGTGCAACTACCGC
GATGTGCGCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGTGGCTCTCAGCTGTCAATGT
GCACTCTGCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCGCTTCCAGGCCTCCTCTTCC
TCAAAGGCCCCTCCCCCCAGCCTTCCAAGTCCATCCCGACTCCCGGGGCCCTCAGACACCCCGATCCTCCCACAATAAAGGCTTCTCAAT

>85769_85769_1_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000245222_CGB7_chr19_49558265_ENST00000356213_length(amino acids)=194AA_BP=1
MEAGVITGQGVVLGTPAVSGAAAAECTLTAESHGVGDHGVHAARAAREPDGLEAHIAVVAHHLRQGRQDPLQHAGHGGAVAGTDGGVDGD
AHGAALLLHSQGGIDGAAPWPKHLPGCPCPAHAQQQQQQQPLVLLLLCFKVSIHLLVLCSVTSTGPWPWVLSHSRLVGARSQVSLSWPDL

--------------------------------------------------------------
>85769_85769_2_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000245222_CGB7_chr19_49558265_ENST00000377280_length(transcript)=905nt_BP=405nt
CGACTGACTAGCCGGGCGATAACGGCAGAGAGCATAGAGCGCAGGAACAAGCGCAACGTCCAAGAGGGAAGGGCCAGCACGTCGGGGGCC
TCTCTGGCCCTACCCAGGCCGTGTTCTCGATAGCTTTCCGGAAGAAAGGGATCTGGGAGCGAGATGCGTGTAGCTAGCACGATGCGTCGC
GCGGTGACGCTCTGGCCCGACGCCGACGGCCTCTCAGTGGCTCCCGGAGGACCCGGCGGGCCCAGTGTTGGAGAGCTGAAGGTCAGGCCA
GGACAGTGAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTGATGTAACAGAGCAGAGGAC
CAGCAGATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAGCATGGGCGGGACATGGGCA
TCCAGGGAGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCCCGTGTGCATCACCGTCAAC
ACCACCATCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCAGGTGGTGTGCAACTACCGC
GATGTGCGCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGTGGCTCTCAGCTGTCAATGT
GCACTCTGCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCGCTTCCAGGCCTCCTCTTCC
TCAAAGGCCCCTCCCCCCAGCCTTCCAAGTCCATCCCGACTCCCGGGGCCCTCAGACACCCCGATCCTCCCACAATAAAGGCTTCTCAAT

>85769_85769_2_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000245222_CGB7_chr19_49558265_ENST00000377280_length(amino acids)=173AA_BP=12
MNGHLEAEEQQDQGLLLLLLLSMGGTWASREMLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDV

--------------------------------------------------------------
>85769_85769_3_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000245222_CGB7_chr19_49558265_ENST00000596965_length(transcript)=904nt_BP=405nt
CGACTGACTAGCCGGGCGATAACGGCAGAGAGCATAGAGCGCAGGAACAAGCGCAACGTCCAAGAGGGAAGGGCCAGCACGTCGGGGGCC
TCTCTGGCCCTACCCAGGCCGTGTTCTCGATAGCTTTCCGGAAGAAAGGGATCTGGGAGCGAGATGCGTGTAGCTAGCACGATGCGTCGC
GCGGTGACGCTCTGGCCCGACGCCGACGGCCTCTCAGTGGCTCCCGGAGGACCCGGCGGGCCCAGTGTTGGAGAGCTGAAGGTCAGGCCA
GGACAGTGAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTGATGTAACAGAGCAGAGGAC
CAGCAGATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAGCATGGGCGGGACATGGGCA
TCCAGGGAGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCCCGTGTGCATCACCGTCAAC
ACCACCATCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCAGGTGGTGTGCAACTACCGC
GATGTGCGCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGTGGCTCTCAGCTGTCAATGT
GCACTCTGCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCGCTTCCAGGCCTCCTCTTCC
TCAAAGGCCCCTCCCCCCAGCCTTCCAAGTCCATCCCGACTCCCGGGGCCCTCAGACACCCCGATCCTCCCACAATAAAGGCTTCTCAAT

>85769_85769_3_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000245222_CGB7_chr19_49558265_ENST00000596965_length(amino acids)=194AA_BP=1
MEAGVITGQGVVLGTPAVSGAAAAECTLTAESHGVGDHGVHAARAAREPDGLEAHIAVVAHHLRQGRQDPLQHAGHGGAVAGTDGGVDGD
AHGAALLLHSQGGIDGAAPWPKHLPGCPCPAHAQQQQQQQPLVLLLLCFKVSIHLLVLCSVTSTGPWPWVLSHSRLVGARSQVSLSWPDL

--------------------------------------------------------------
>85769_85769_4_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000245222_CGB7_chr19_49558265_ENST00000597853_length(transcript)=904nt_BP=405nt
CGACTGACTAGCCGGGCGATAACGGCAGAGAGCATAGAGCGCAGGAACAAGCGCAACGTCCAAGAGGGAAGGGCCAGCACGTCGGGGGCC
TCTCTGGCCCTACCCAGGCCGTGTTCTCGATAGCTTTCCGGAAGAAAGGGATCTGGGAGCGAGATGCGTGTAGCTAGCACGATGCGTCGC
GCGGTGACGCTCTGGCCCGACGCCGACGGCCTCTCAGTGGCTCCCGGAGGACCCGGCGGGCCCAGTGTTGGAGAGCTGAAGGTCAGGCCA
GGACAGTGAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTGATGTAACAGAGCAGAGGAC
CAGCAGATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAGCATGGGCGGGACATGGGCA
TCCAGGGAGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCCCGTGTGCATCACCGTCAAC
ACCACCATCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCAGGTGGTGTGCAACTACCGC
GATGTGCGCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGTGGCTCTCAGCTGTCAATGT
GCACTCTGCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCGCTTCCAGGCCTCCTCTTCC
TCAAAGGCCCCTCCCCCCAGCCTTCCAAGTCCATCCCGACTCCCGGGGCCCTCAGACACCCCGATCCTCCCACAATAAAGGCTTCTCAAT

>85769_85769_4_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000245222_CGB7_chr19_49558265_ENST00000597853_length(amino acids)=194AA_BP=1
MEAGVITGQGVVLGTPAVSGAAAAECTLTAESHGVGDHGVHAARAAREPDGLEAHIAVVAHHLRQGRQDPLQHAGHGGAVAGTDGGVDGD
AHGAALLLHSQGGIDGAAPWPKHLPGCPCPAHAQQQQQQQPLVLLLLCFKVSIHLLVLCSVTSTGPWPWVLSHSRLVGARSQVSLSWPDL

--------------------------------------------------------------
>85769_85769_5_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000598088_CGB7_chr19_49558265_ENST00000356213_length(transcript)=807nt_BP=308nt
AGTGTTGGAGGTGAGGAGGCGGGGCTGGCAGGGCTAGTCGGGGCATCTGGAAATTTCCGACCCCACGCTTCGGGCGTTTCCTTATCAGGT
TCACCGCTCCCTGATCTCGCGCTGCACTTCGTAGGCGCAGCCGCTGCTTGGGAAGTCCTACTTAAGAGCTGAAGGTCAGGCCAGGACAGT
GAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTGATGTAACAGAGCAGAGGACCAGCAGA
TGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAGCATGGGCGGGACATGGGCATCCAGGG
AGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCCCGTGTGCATCACCGTCAACACCACCA
TCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCAGGTGGTGTGCAACTACCGCGATGTGC
GCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGTGGCTCTCAGCTGTCAATGTGCACTCT
GCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCGCTTCCAGGCCTCCTCTTCCTCAAAGG

>85769_85769_5_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000598088_CGB7_chr19_49558265_ENST00000356213_length(amino acids)=233AA_BP=1
MEAGVITGQGVVLGTPAVSGAAAAECTLTAESHGVGDHGVHAARAAREPDGLEAHIAVVAHHLRQGRQDPLQHAGHGGAVAGTDGGVDGD
AHGAALLLHSQGGIDGAAPWPKHLPGCPCPAHAQQQQQQQPLVLLLLCFKVSIHLLVLCSVTSTGPWPWVLSHSRLVGARSQVSLSWPDL

--------------------------------------------------------------
>85769_85769_6_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000598088_CGB7_chr19_49558265_ENST00000377280_length(transcript)=808nt_BP=308nt
AGTGTTGGAGGTGAGGAGGCGGGGCTGGCAGGGCTAGTCGGGGCATCTGGAAATTTCCGACCCCACGCTTCGGGCGTTTCCTTATCAGGT
TCACCGCTCCCTGATCTCGCGCTGCACTTCGTAGGCGCAGCCGCTGCTTGGGAAGTCCTACTTAAGAGCTGAAGGTCAGGCCAGGACAGT
GAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTGATGTAACAGAGCAGAGGACCAGCAGA
TGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAGCATGGGCGGGACATGGGCATCCAGGG
AGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCCCGTGTGCATCACCGTCAACACCACCA
TCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCAGGTGGTGTGCAACTACCGCGATGTGC
GCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGTGGCTCTCAGCTGTCAATGTGCACTCT
GCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCGCTTCCAGGCCTCCTCTTCCTCAAAGG

>85769_85769_6_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000598088_CGB7_chr19_49558265_ENST00000377280_length(amino acids)=173AA_BP=12
MNGHLEAEEQQDQGLLLLLLLSMGGTWASREMLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDV

--------------------------------------------------------------
>85769_85769_7_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000598088_CGB7_chr19_49558265_ENST00000596965_length(transcript)=807nt_BP=308nt
AGTGTTGGAGGTGAGGAGGCGGGGCTGGCAGGGCTAGTCGGGGCATCTGGAAATTTCCGACCCCACGCTTCGGGCGTTTCCTTATCAGGT
TCACCGCTCCCTGATCTCGCGCTGCACTTCGTAGGCGCAGCCGCTGCTTGGGAAGTCCTACTTAAGAGCTGAAGGTCAGGCCAGGACAGT
GAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTGATGTAACAGAGCAGAGGACCAGCAGA
TGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAGCATGGGCGGGACATGGGCATCCAGGG
AGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCCCGTGTGCATCACCGTCAACACCACCA
TCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCAGGTGGTGTGCAACTACCGCGATGTGC
GCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGTGGCTCTCAGCTGTCAATGTGCACTCT
GCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCGCTTCCAGGCCTCCTCTTCCTCAAAGG

>85769_85769_7_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000598088_CGB7_chr19_49558265_ENST00000596965_length(amino acids)=233AA_BP=1
MEAGVITGQGVVLGTPAVSGAAAAECTLTAESHGVGDHGVHAARAAREPDGLEAHIAVVAHHLRQGRQDPLQHAGHGGAVAGTDGGVDGD
AHGAALLLHSQGGIDGAAPWPKHLPGCPCPAHAQQQQQQQPLVLLLLCFKVSIHLLVLCSVTSTGPWPWVLSHSRLVGARSQVSLSWPDL

--------------------------------------------------------------
>85769_85769_8_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000598088_CGB7_chr19_49558265_ENST00000597853_length(transcript)=807nt_BP=308nt
AGTGTTGGAGGTGAGGAGGCGGGGCTGGCAGGGCTAGTCGGGGCATCTGGAAATTTCCGACCCCACGCTTCGGGCGTTTCCTTATCAGGT
TCACCGCTCCCTGATCTCGCGCTGCACTTCGTAGGCGCAGCCGCTGCTTGGGAAGTCCTACTTAAGAGCTGAAGGTCAGGCCAGGACAGT
GAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTGATGTAACAGAGCAGAGGACCAGCAGA
TGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAGCATGGGCGGGACATGGGCATCCAGGG
AGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCCCGTGTGCATCACCGTCAACACCACCA
TCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCAGGTGGTGTGCAACTACCGCGATGTGC
GCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGTGGCTCTCAGCTGTCAATGTGCACTCT
GCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCGCTTCCAGGCCTCCTCTTCCTCAAAGG

>85769_85769_8_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000598088_CGB7_chr19_49558265_ENST00000597853_length(amino acids)=233AA_BP=1
MEAGVITGQGVVLGTPAVSGAAAAECTLTAESHGVGDHGVHAARAAREPDGLEAHIAVVAHHLRQGRQDPLQHAGHGGAVAGTDGGVDGD
AHGAALLLHSQGGIDGAAPWPKHLPGCPCPAHAQQQQQQQPLVLLLLCFKVSIHLLVLCSVTSTGPWPWVLSHSRLVGARSQVSLSWPDL

--------------------------------------------------------------
>85769_85769_9_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000600537_CGB7_chr19_49558265_ENST00000356213_length(transcript)=743nt_BP=244nt
AGCTAGCACGATGCGTCGCGCGGTGACGCTCTGGCCCGACGCCGACGGCCTCTCAGTGGCTCCCGGAGGACCCGGCGGGCCCAGTGTTGG
AGAGCTGAAGGTCAGGCCAGGACAGTGAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTG
ATGTAACAGAGCAGAGGACCAGCAGATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAG
CATGGGCGGGACATGGGCATCCAGGGAGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCC
CGTGTGCATCACCGTCAACACCACCATCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCA
GGTGGTGTGCAACTACCGCGATGTGCGCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGT
GGCTCTCAGCTGTCAATGTGCACTCTGCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCG
CTTCCAGGCCTCCTCTTCCTCAAAGGCCCCTCCCCCCAGCCTTCCAAGTCCATCCCGACTCCCGGGGCCCTCAGACACCCCGATCCTCCC

>85769_85769_9_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000600537_CGB7_chr19_49558265_ENST00000356213_length(amino acids)=194AA_BP=1
MEAGVITGQGVVLGTPAVSGAAAAECTLTAESHGVGDHGVHAARAAREPDGLEAHIAVVAHHLRQGRQDPLQHAGHGGAVAGTDGGVDGD
AHGAALLLHSQGGIDGAAPWPKHLPGCPCPAHAQQQQQQQPLVLLLLCFKVSIHLLVLCSVTSTGPWPWVLSHSRLVGARSQVSLSWPDL

--------------------------------------------------------------
>85769_85769_10_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000600537_CGB7_chr19_49558265_ENST00000377280_length(transcript)=744nt_BP=244nt
AGCTAGCACGATGCGTCGCGCGGTGACGCTCTGGCCCGACGCCGACGGCCTCTCAGTGGCTCCCGGAGGACCCGGCGGGCCCAGTGTTGG
AGAGCTGAAGGTCAGGCCAGGACAGTGAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTG
ATGTAACAGAGCAGAGGACCAGCAGATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAG
CATGGGCGGGACATGGGCATCCAGGGAGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCC
CGTGTGCATCACCGTCAACACCACCATCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCA
GGTGGTGTGCAACTACCGCGATGTGCGCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGT
GGCTCTCAGCTGTCAATGTGCACTCTGCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCG
CTTCCAGGCCTCCTCTTCCTCAAAGGCCCCTCCCCCCAGCCTTCCAAGTCCATCCCGACTCCCGGGGCCCTCAGACACCCCGATCCTCCC

>85769_85769_10_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000600537_CGB7_chr19_49558265_ENST00000377280_length(amino acids)=173AA_BP=12
MNGHLEAEEQQDQGLLLLLLLSMGGTWASREMLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDV

--------------------------------------------------------------
>85769_85769_11_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000600537_CGB7_chr19_49558265_ENST00000596965_length(transcript)=743nt_BP=244nt
AGCTAGCACGATGCGTCGCGCGGTGACGCTCTGGCCCGACGCCGACGGCCTCTCAGTGGCTCCCGGAGGACCCGGCGGGCCCAGTGTTGG
AGAGCTGAAGGTCAGGCCAGGACAGTGAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTG
ATGTAACAGAGCAGAGGACCAGCAGATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAG
CATGGGCGGGACATGGGCATCCAGGGAGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCC
CGTGTGCATCACCGTCAACACCACCATCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCA
GGTGGTGTGCAACTACCGCGATGTGCGCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGT
GGCTCTCAGCTGTCAATGTGCACTCTGCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCG
CTTCCAGGCCTCCTCTTCCTCAAAGGCCCCTCCCCCCAGCCTTCCAAGTCCATCCCGACTCCCGGGGCCCTCAGACACCCCGATCCTCCC

>85769_85769_11_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000600537_CGB7_chr19_49558265_ENST00000596965_length(amino acids)=194AA_BP=1
MEAGVITGQGVVLGTPAVSGAAAAECTLTAESHGVGDHGVHAARAAREPDGLEAHIAVVAHHLRQGRQDPLQHAGHGGAVAGTDGGVDGD
AHGAALLLHSQGGIDGAAPWPKHLPGCPCPAHAQQQQQQQPLVLLLLCFKVSIHLLVLCSVTSTGPWPWVLSHSRLVGARSQVSLSWPDL

--------------------------------------------------------------
>85769_85769_12_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000600537_CGB7_chr19_49558265_ENST00000597853_length(transcript)=743nt_BP=244nt
AGCTAGCACGATGCGTCGCGCGGTGACGCTCTGGCCCGACGCCGACGGCCTCTCAGTGGCTCCCGGAGGACCCGGCGGGCCCAGTGTTGG
AGAGCTGAAGGTCAGGCCAGGACAGTGAGACCTGACTCCTTGCTCCTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTG
ATGTAACAGAGCAGAGGACCAGCAGATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGGGGCTGCTGCTGTTGCTGCTGCTGAG
CATGGGCGGGACATGGGCATCCAGGGAGATGCTTCGGCCACGGTGCCGCCCCATCAATGCCACCCTGGCTGTGGAGAAGGAGGGCTGCCC
CGTGTGCATCACCGTCAACACCACCATCTGTGCCGGCTACTGCCCCACCATGACCCGCGTGCTGCAGGGGGTCCTGCCGGCCCTGCCTCA
GGTGGTGTGCAACTACCGCGATGTGCGCTTCGAGTCCATCCGGCTCCCTGGCTGCCCGCGCGGCGTGAACCCCGTGGTCTCCTACGCCGT
GGCTCTCAGCTGTCAATGTGCACTCTGCCGCCGCAGCACCACTGACTGCGGGGGTCCCAAGGACCACCCCTTGACCTGTGATGACCCCCG
CTTCCAGGCCTCCTCTTCCTCAAAGGCCCCTCCCCCCAGCCTTCCAAGTCCATCCCGACTCCCGGGGCCCTCAGACACCCCGATCCTCCC

>85769_85769_12_SPHK2-CGB7_SPHK2_chr19_49123810_ENST00000600537_CGB7_chr19_49558265_ENST00000597853_length(amino acids)=194AA_BP=1
MEAGVITGQGVVLGTPAVSGAAAAECTLTAESHGVGDHGVHAARAAREPDGLEAHIAVVAHHLRQGRQDPLQHAGHGGAVAGTDGGVDGD
AHGAALLLHSQGGIDGAAPWPKHLPGCPCPAHAQQQQQQQPLVLLLLCFKVSIHLLVLCSVTSTGPWPWVLSHSRLVGARSQVSLSWPDL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPHK2-CGB7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPHK2-CGB7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPHK2-CGB7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPHK2C0025261Memory Disorders1CTD_human
HgeneSPHK2C0233794Memory impairment1CTD_human
HgeneSPHK2C0238281Middle Cerebral Artery Syndrome1CTD_human
HgeneSPHK2C0740376Middle Cerebral Artery Thrombosis1CTD_human
HgeneSPHK2C0740391Middle Cerebral Artery Occlusion1CTD_human
HgeneSPHK2C0740392Infarction, Middle Cerebral Artery1CTD_human
HgeneSPHK2C0751292Age-Related Memory Disorders1CTD_human
HgeneSPHK2C0751293Memory Disorder, Semantic1CTD_human
HgeneSPHK2C0751294Memory Disorder, Spatial1CTD_human
HgeneSPHK2C0751295Memory Loss1CTD_human
HgeneSPHK2C0751845Middle Cerebral Artery Embolus1CTD_human
HgeneSPHK2C0751846Left Middle Cerebral Artery Infarction1CTD_human
HgeneSPHK2C0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
HgeneSPHK2C0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
HgeneSPHK2C0751849Right Middle Cerebral Artery Infarction1CTD_human