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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AVEN-SCG5 (FusionGDB2 ID:HG57099TG6447)

Fusion Gene Summary for AVEN-SCG5

check button Fusion gene summary
Fusion gene informationFusion gene name: AVEN-SCG5
Fusion gene ID: hg57099tg6447
HgeneTgene
Gene symbol

AVEN

SCG5

Gene ID

57099

6447

Gene nameapoptosis and caspase activation inhibitorsecretogranin V
SynonymsPDCD127B2|P7B2|SGNE1|SgV
Cytomap('AVEN')('SCG5')

15q14

15q13.3

Type of geneprotein-codingprotein-coding
Descriptioncell death regulator Avenapoptosis, caspase activation inhibitorprogrammed cell death 12neuroendocrine protein 7B2pituitary polypeptideprohormone convertase chaperonesecretogranin-5secretory granule endocrine protein Isecretory granule, neuroendocrine protein 1 (7B2 protein)
Modification date2020031320200313
UniProtAcc

Q9NQS1

.
Ensembl transtripts involved in fusion geneENST00000306730, ENST00000558136, 
Fusion gene scores* DoF score7 X 6 X 5=2105 X 3 X 5=75
# samples 85
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AVEN [Title/Abstract] AND SCG5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAVEN(34295233)-SCG5(32971967), # samples:1
Anticipated loss of major functional domain due to fusion event.AVEN-SCG5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AVEN-SCG5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAVEN

GO:0043066

negative regulation of apoptotic process

10949025


check buttonFusion gene breakpoints across AVEN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SCG5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A2QM-01AAVENchr15

34295233

-SCG5chr15

32971967

+


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Fusion Gene ORF analysis for AVEN-SCG5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000306730ENST00000498069AVENchr15

34295233

-SCG5chr15

32971967

+
In-frameENST00000306730ENST00000300175AVENchr15

34295233

-SCG5chr15

32971967

+
In-frameENST00000306730ENST00000413748AVENchr15

34295233

-SCG5chr15

32971967

+
In-frameENST00000306730ENST00000494364AVENchr15

34295233

-SCG5chr15

32971967

+
In-frameENST00000306730ENST00000497208AVENchr15

34295233

-SCG5chr15

32971967

+
intron-3CDSENST00000558136ENST00000300175AVENchr15

34295233

-SCG5chr15

32971967

+
intron-3CDSENST00000558136ENST00000413748AVENchr15

34295233

-SCG5chr15

32971967

+
intron-3CDSENST00000558136ENST00000494364AVENchr15

34295233

-SCG5chr15

32971967

+
intron-3CDSENST00000558136ENST00000497208AVENchr15

34295233

-SCG5chr15

32971967

+
intron-3UTRENST00000558136ENST00000498069AVENchr15

34295233

-SCG5chr15

32971967

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000306730AVENchr1534295233-ENST00000413748SCG5chr1532971967+1474575130984284
ENST00000306730AVENchr1534295233-ENST00000300175SCG5chr1532971967+1477575130987285
ENST00000306730AVENchr1534295233-ENST00000494364SCG5chr1532971967+1410575130930266
ENST00000306730AVENchr1534295233-ENST00000497208SCG5chr1532971967+1214575130933267

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306730ENST00000413748AVENchr1534295233-SCG5chr1532971967+0.005893040.994107
ENST00000306730ENST00000300175AVENchr1534295233-SCG5chr1532971967+0.0039269990.996073
ENST00000306730ENST00000494364AVENchr1534295233-SCG5chr1532971967+0.006681160.9933188
ENST00000306730ENST00000497208AVENchr1534295233-SCG5chr1532971967+0.0059111250.9940889

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Fusion Genomic Features for AVEN-SCG5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AVENchr1534295232-SCG5chr1532971966+1.74E-070.9999999
AVENchr1534295232-SCG5chr1532971966+1.74E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AVEN-SCG5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:34295233/chr15:32971967)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AVEN

Q9NQS1

.
FUNCTION: Protects against apoptosis mediated by Apaf-1.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAVENchr15:34295233chr15:32971967ENST00000306730-265_85148363.0Compositional biasNote=Ala/Gly-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AVEN-SCG5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8532_8532_1_AVEN-SCG5_AVEN_chr15_34295233_ENST00000306730_SCG5_chr15_32971967_ENST00000300175_length(transcript)=1477nt_BP=575nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTTGAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGG
AAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGATATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAG
GGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACAT
CGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAA
AACAGCAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGA
ACATGACTATCCAGGCTTGGGCAAGTGGAACAAGAAACTCCTTTACGAGAAGATGAAGGGAGGAGAGAGACGAAAGCGGAGGAGTGTCAA
TCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCCCCATTTTTCAGATGAGGATAAGGATCCAGAGTAAAG
AGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATGTGCACGTGTAAATGGAGTCCCTGTGAATGACAGCAT
GTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATTGTCTTCACACCGATGATTCTGCTTTTTGCTAAATTA
GAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCATAAAAATTAAAATGTGAATGTCAACAATAAAAAGCA
AGACTATGAAAGGCTCAGATTTCTTGCAGTTTAAAATGGTGTCTGAGGTTGTACTATTTTGGCCAAGTCTGTAGAAAGCTGTCATTTGAT
TTTGATTATGTAGTTCATCCAGCCCTTGGGCATTGTTATACACCAGTAAAGAAGGCTGTACTCAAGAGGAGGAGCTGACACATTTCACTT

>8532_8532_1_AVEN-SCG5_AVEN_chr15_34295233_ENST00000306730_SCG5_chr15_32971967_ENST00000300175_length(amino acids)=285AA_BP=141
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPV
EDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDF
SEDQGYPDPPNPCPVGKTADDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVA

--------------------------------------------------------------
>8532_8532_2_AVEN-SCG5_AVEN_chr15_34295233_ENST00000306730_SCG5_chr15_32971967_ENST00000413748_length(transcript)=1474nt_BP=575nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTTGAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGG
AAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGATATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAG
GGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACAT
CGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAA
AACAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGAACA
TGACTATCCAGGCTTGGGCAAGTGGAACAAGAAACTCCTTTACGAGAAGATGAAGGGAGGAGAGAGACGAAAGCGGAGGAGTGTCAATCC
ATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCCCCATTTTTCAGATGAGGATAAGGATCCAGAGTAAAGAGA
AGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATGTGCACGTGTAAATGGAGTCCCTGTGAATGACAGCATGTT
TCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATTGTCTTCACACCGATGATTCTGCTTTTTGCTAAATTAGAA
TAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCATAAAAATTAAAATGTGAATGTCAACAATAAAAAGCAAGA
CTATGAAAGGCTCAGATTTCTTGCAGTTTAAAATGGTGTCTGAGGTTGTACTATTTTGGCCAAGTCTGTAGAAAGCTGTCATTTGATTTT
GATTATGTAGTTCATCCAGCCCTTGGGCATTGTTATACACCAGTAAAGAAGGCTGTACTCAAGAGGAGGAGCTGACACATTTCACTTGGC

>8532_8532_2_AVEN-SCG5_AVEN_chr15_34295233_ENST00000306730_SCG5_chr15_32971967_ENST00000413748_length(amino acids)=284AA_BP=141
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPV
EDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDF
SEDQGYPDPPNPCPVGKTDDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVAK

--------------------------------------------------------------
>8532_8532_3_AVEN-SCG5_AVEN_chr15_34295233_ENST00000306730_SCG5_chr15_32971967_ENST00000494364_length(transcript)=1410nt_BP=575nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTTGAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGG
AAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGATATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAG
GGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACAT
CGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAA
AACAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGAACA
TGACTATCCAGGCTTGGGCAAGTGGAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCCCCA
TTTTTCAGATGAGGATAAGGATCCAGAGTAAAGAGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATGTGC
ACGTGTAAATGGAGTCCCTGTGAATGACAGCATGTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATTGTC
TTCACACCGATGATTCTGCTTTTTGCTAAATTAGAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCATAA
AAATTAAAATGTGAATGTCAACAATAAAAAGCAAGACTATGAAAGGCTCAGATTTCTTGCAGTTTAAAATGGTGTCTGAGGTTGTACTAT
TTTGGCCAAGTCTGTAGAAAGCTGTCATTTGATTTTGATTATGTAGTTCATCCAGCCCTTGGGCATTGTTATACACCAGTAAAGAAGGCT

>8532_8532_3_AVEN-SCG5_AVEN_chr15_34295233_ENST00000306730_SCG5_chr15_32971967_ENST00000494364_length(amino acids)=266AA_BP=141
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPV
EDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDF

--------------------------------------------------------------
>8532_8532_4_AVEN-SCG5_AVEN_chr15_34295233_ENST00000306730_SCG5_chr15_32971967_ENST00000497208_length(transcript)=1214nt_BP=575nt
GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA
GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG
CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG
AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG
GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTTGAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGG
AAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGATATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAG
GGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACAT
CGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAA
AACAGCAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGA
ACATGACTATCCAGGCTTGGGCAAGTGGAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCC
CCATTTTTCAGATGAGGATAAGGATCCAGAGTAAAGAGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATG
TGCACGTGTAAATGGAGTCCCTGTGAATGACAGCATGTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATT
GTCTTCACACCGATGATTCTGCTTTTTGCTAAATTAGAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCA

>8532_8532_4_AVEN-SCG5_AVEN_chr15_34295233_ENST00000306730_SCG5_chr15_32971967_ENST00000497208_length(amino acids)=267AA_BP=141
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPV
EDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AVEN-SCG5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AVEN-SCG5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AVEN-SCG5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAVENC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0025149Medulloblastoma1CTD_human
TgeneC0205833Medullomyoblastoma1CTD_human
TgeneC0278510Childhood Medulloblastoma1CTD_human
TgeneC0278876Adult Medulloblastoma1CTD_human
TgeneC0751291Desmoplastic Medulloblastoma1CTD_human
TgeneC1275668Melanotic medulloblastoma1CTD_human