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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ANO2-NUDT3 (FusionGDB2 ID:HG57101TG11165) |
Fusion Gene Summary for ANO2-NUDT3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANO2-NUDT3 | Fusion gene ID: hg57101tg11165 | Hgene | Tgene | Gene symbol | ANO2 | NUDT3 | Gene ID | 57101 | 11165 |
| Gene name | anoctamin 2 | nudix hydrolase 3 | |
| Synonyms | C12orf3|TMEM16B | DIPP|DIPP-1|DIPP1 | |
| Cytomap | ('ANO2')('NUDT3') 12p13.31 | 6p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | anoctamin-2anoctamin 2, calcium activated chloride channeltransmembrane protein 16B (eight membrane-spanning domains) | diphosphoinositol polyphosphate phosphohydrolase 1diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1nucleoside diphosphate-linked moiety X motif 3nudix (nucleoside diphosphate linked moiety X)-type motif 3nudix motif 3 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000327087, ENST00000356134, ENST00000546188, ENST00000538154, | ||
| Fusion gene scores | * DoF score | 8 X 9 X 6=432 | 13 X 7 X 8=728 |
| # samples | 9 | 15 | |
| ** MAII score | log2(9/432*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/728*10)=-2.27897594970282 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ANO2 [Title/Abstract] AND NUDT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ANO2(5915218)-NUDT3(34263462), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | ANO2-NUDT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ANO2-NUDT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ANO2-NUDT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ANO2-NUDT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NUDT3 | GO:0071544 | diphosphoinositol polyphosphate catabolic process | 10585413 |
| Fusion gene breakpoints across ANO2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across NUDT3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-PC-A5DN-01A | ANO2 | chr12 | 5915218 | - | NUDT3 | chr6 | 34263462 | - |
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Fusion Gene ORF analysis for ANO2-NUDT3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000327087 | ENST00000607016 | ANO2 | chr12 | 5915218 | - | NUDT3 | chr6 | 34263462 | - |
| In-frame | ENST00000356134 | ENST00000607016 | ANO2 | chr12 | 5915218 | - | NUDT3 | chr6 | 34263462 | - |
| In-frame | ENST00000546188 | ENST00000607016 | ANO2 | chr12 | 5915218 | - | NUDT3 | chr6 | 34263462 | - |
| intron-3CDS | ENST00000538154 | ENST00000607016 | ANO2 | chr12 | 5915218 | - | NUDT3 | chr6 | 34263462 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000327087 | ANO2 | chr12 | 5915218 | - | ENST00000607016 | NUDT3 | chr6 | 34263462 | - | 10433 | 1050 | 72 | 1358 | 428 |
| ENST00000546188 | ANO2 | chr12 | 5915218 | - | ENST00000607016 | NUDT3 | chr6 | 34263462 | - | 10436 | 1053 | 72 | 1361 | 429 |
| ENST00000356134 | ANO2 | chr12 | 5915218 | - | ENST00000607016 | NUDT3 | chr6 | 34263462 | - | 10436 | 1053 | 72 | 1361 | 429 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000327087 | ENST00000607016 | ANO2 | chr12 | 5915218 | - | NUDT3 | chr6 | 34263462 | - | 0.000220041 | 0.99978 |
| ENST00000546188 | ENST00000607016 | ANO2 | chr12 | 5915218 | - | NUDT3 | chr6 | 34263462 | - | 0.000180774 | 0.9998192 |
| ENST00000356134 | ENST00000607016 | ANO2 | chr12 | 5915218 | - | NUDT3 | chr6 | 34263462 | - | 0.000180774 | 0.9998192 |
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Fusion Genomic Features for ANO2-NUDT3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ANO2-NUDT3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:5915218/chr6:34263462) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NUDT3 | chr12:5915218 | chr6:34263462 | ENST00000607016 | 1 | 5 | 89_91 | 70 | 173.0 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 1001_1003 | 326 | 999.0 | Motif | Note=DLG4 binding (PDZ) |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 1001_1003 | 327 | 1000.0 | Motif | Note=DLG4 binding (PDZ) |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 1_365 | 326 | 999.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 387_434 | 326 | 999.0 | Topological domain | Extracellular |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 456_538 | 326 | 999.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 560_582 | 326 | 999.0 | Topological domain | Extracellular |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 604_623 | 326 | 999.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 645_748 | 326 | 999.0 | Topological domain | Extracellular |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 770_801 | 326 | 999.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 823_907 | 326 | 999.0 | Topological domain | Extracellular |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 929_1003 | 326 | 999.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 1_365 | 327 | 1000.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 387_434 | 327 | 1000.0 | Topological domain | Extracellular |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 456_538 | 327 | 1000.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 560_582 | 327 | 1000.0 | Topological domain | Extracellular |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 604_623 | 327 | 1000.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 645_748 | 327 | 1000.0 | Topological domain | Extracellular |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 770_801 | 327 | 1000.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 823_907 | 327 | 1000.0 | Topological domain | Extracellular |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 929_1003 | 327 | 1000.0 | Topological domain | Cytoplasmic |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 366_386 | 326 | 999.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 435_455 | 326 | 999.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 539_559 | 326 | 999.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 583_603 | 326 | 999.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 624_644 | 326 | 999.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 749_769 | 326 | 999.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 802_822 | 326 | 999.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000327087 | - | 9 | 26 | 908_928 | 326 | 999.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 366_386 | 327 | 1000.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 435_455 | 327 | 1000.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 539_559 | 327 | 1000.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 583_603 | 327 | 1000.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 624_644 | 327 | 1000.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 749_769 | 327 | 1000.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 802_822 | 327 | 1000.0 | Transmembrane | Helical |
| Hgene | ANO2 | chr12:5915218 | chr6:34263462 | ENST00000356134 | - | 10 | 27 | 908_928 | 327 | 1000.0 | Transmembrane | Helical |
| Tgene | NUDT3 | chr12:5915218 | chr6:34263462 | ENST00000607016 | 1 | 5 | 17_142 | 70 | 173.0 | Domain | Nudix hydrolase | |
| Tgene | NUDT3 | chr12:5915218 | chr6:34263462 | ENST00000607016 | 1 | 5 | 51_72 | 70 | 173.0 | Motif | Note=Nudix box | |
| Tgene | NUDT3 | chr12:5915218 | chr6:34263462 | ENST00000607016 | 1 | 5 | 18_20 | 70 | 173.0 | Region | Substrate binding | |
| Tgene | NUDT3 | chr12:5915218 | chr6:34263462 | ENST00000607016 | 1 | 5 | 39_41 | 70 | 173.0 | Region | Substrate binding |
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Fusion Gene Sequence for ANO2-NUDT3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >4874_4874_1_ANO2-NUDT3_ANO2_chr12_5915218_ENST00000327087_NUDT3_chr6_34263462_ENST00000607016_length(transcript)=10433nt_BP=1050nt CCAGGCTCCTTCTCTATAAAGTGGGATCTATCATGACCAGCCTACCTTATCAATATAGGAGAGAAAATCTTCATGCCTGAAGATATACCC CTGCTCCCTGGCTCCCCACGCCGGCTGAGCCCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGCGGTGGAGAGAGCACCCGCAGCAGCTCTGTC ATCAACAACTATCTGGATGCCAATGAGCCTGTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGCCACTCGCTGGCTATCGTCTCCAATGGGGAG ACAGGCAAGGAGCCTCATGCTGGGGGCCCAGGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAAAGCCAGGGATCCATCTTTGTCCGGATACAC GCCCCGTGGCAGGTGCTGGCCAGAGAGGCAGAATTCTTGAAGATCAAAGTTCCTACCAAGAAAATGTACGAGATCAAAGCAGGAGGCAGC ATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAAAAC CTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGCATT GTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGGTATTAACTCTCTGATCGCAAACAATATCTATGAGGCT GCCTACCCTCTTCATGACGGTGAATACGATAGTCCAGAGGACGATATGAATGACAGGAAGGCTGGAGTAAAAGGGACATTGGGAAGATTA GTTGGAATTTTTGAGAACCAGGAGAGGAAGCACAGGACGTATGTCTATGTGCTCATTGTCACTGAAGTGCTGGAAGACTGGGAAGATTCA GTTAACATTGGAAGGAAGAGGGAATGGTTTAAAATAGAAGACGCCATAAAAGTGCTGCAGTATCACAAACCCGTGCAGGCATCATATTTT GAAACATTGAGGCAAGGCTACTCAGCCAACAATGGCACCCCAGTCGTGGCCACCACATACTCGGTTTCTGCTCAGAGCTCGATGTCAGGC ATCAGATGACTGAAGACTTCCTGTAAGAGAAATGGAAATTGGAAACTAGACTGAAGTGCAAATCTTCCCTCTCACCCTGGCTCTTTCCAC TTCTCACAGGCCTCCTCTTTCAAATAAGGCATGGTGGGCAGCAAAGAAAGGGTGTATTGATAATGTTGCTGTTTGGTGTTAAGTGATGGG GCTTTTTCTTCTGTTTTTATTGAGGGTGGGGGTTGGGTGTGTAATTTGTAAGTACTTTTGTGCATGATCTGTCCCTCCCTCTTCCCACCC CTGCAGTCCTCTGAAGAGAGGCCAACAGCCTTCCCCTGCCTTGGATTCTGAAGTGTTCCTGTTTGTCTTATCCTGGCCCTGGCCAGACGT TTTCTTTGATTTTTAATTTTTTTTTTTTATTAAAAGATACCAGTATGAGATGAAAACTTCCAATAATTTGTCCTATAATGTGCTGTACAG TTCAGTAGAGTGGTCACTTTCACTGCAGTATACATTTATCTACACATTATATATCGGACATATAATATGTAAATAAATGACTTCTAGAAA GAGAAATTTGTTTAATTTTTCAAGGTTTTTTTCTCTTTTAATTTGGGCATTTCTAGAATTGAGAGCCTCACAATTAACATACCTTTTTGT TTTCGATGCTAGTGGCTGGGCAGGTTGCCCTGTCCTTTCTCTATTTCCCAGTCATTGACTGTAGATATGGGAAGAGTTTAGCTACCTTCA TAGTGCTCCCAGGACTCATGGCCTTTCCTTCTTTAAGCTGTATTTCCCTGCCCAGAAAGAAACAGGAAGAAACCTTTTTTTATTTTTTTA TTTTTTTTTAACCAAGCAAGGAGCAAATGGCCTCAGCCCAGATCTGTAAAAACAATGATAGAAATTGAATTCTGCCCCACATGTTGACAG TAGAGTTGGAACTGGATTCTTGGGATTACTTATCTAAAAAACTGGAGCATCAGGTCCATTTCTGTTCTGCTGGTTTGGAATCTTTTCCGT AATGCTATTTATTGCCAACAATGGCCTCTCTTTGTGTCCATATATGCCTTACACCGTGCTGACCTGGGTATCATCCATGTGCTCTGAAGC ATCCAACTTTACTTTGCAGGTGCATCAATGTAGTCCTGTCCCTGAACTGAGTAACCGTGTTCCTGAAAAGTACACTAGGGAAATTCACCT GCTTGCTTGTCTTTGTATTGGCATGGCACTTGTGATTGCACCATGGAGCATGCTCAGAGCTATTAAATTGGTCTCCCATCTCCCACCAGG ATATGAAAGGTCCATATGGGAGGCCACGTAATCACTTATTACAGTGGTTACATAATACACTGGCTCACTGCAGACTCTCTTGTTTTTTGA TACAGTTTCGTGCTGGCTTCATTTGCCAATTGTGTTGTTTAGTTCGGAAGTAAGAGGGTCTTGAGATTGAGGGGTAGGGAGGGCTACACT GACTGATCCGTGGCTTAAGACAGGAGATTATCTCTGTACTCCAGTGGCATCTCCTTAGCCAAGATGTGAAATTAAAATCATAGTTCGCCT CATTTAAAAATTCTAATAAAGCACTCAAACTTTGAAAAGCTTTTACTTTTCCCTCCTACTAAAAGAAATGTATGTACCTCATAGCCCTGT GTCATTTAGTGTTCAGCACTTTTGGGAACATCAGTTGGTGAACTTTAAATTTTGCTGTCTACTCACTGGGCACGGTGGCTCACACCTGTA ATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCT ACTAAAAATGCAGAAATTAGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCGAGATAATCGCTTGAACCTGGGAGGCAGAGG TTGCAGTGAGCCGAGATTGCACCACTGTCGTCCAGCCTGGGTGATAAGAGTGAAACTCCATCTCAAAAAAAAAAAAAAAAAATTTTTTTT TTTTTTTTTGCTATATACTCTTAGTTTACATCCTCTCCCCCAATCTTCACACACAGAGCCAAAGAGCAGTTATATTCTTGGGATACCATG ATACCTCTGGGAAAGGAATTATATTCCCAAGGAGAGGTCCCATTGGATAAGAACAATACCATGGGACTTGAGTCTGAATGCCAACTTACT ATTCACACATCCTTCTTAAAAACGAACACACTGTTTCTTTTCCTGACCTAGAGCATTCTAAAGTTCTGTTCAAATAAATAAAGGGCAAAA TAAAGTAGATTTAACCAAGTGCCAGGTGGAATTCAAAAAACACATTCTTCCAGATAAATTCTACCTTTATGGTATGGATTTGAAAGTACT TTGCAGGAAAACAGTCAGTACTCTTTAAAAAGGGACTGCAGGGCTGGGTGTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCA AGGCAGGTGGGTCACTTGAGGCCAGGAGTTTGAGACCAGCCTGACCAACATGGCAAAACCCCATCTCTACTAAAATACAAAAATTAGCTG GGCATGATGGTGCACTCCTGTAATCCCAGCTACTTGGTAGGCTGAAGCATGAGAATTGCTTAAACCTGGGAGGCAGAGGTTGCAGTAAGC CAAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCTGTCTTAATAAATAAATAAGAAAATAAAACGGAACTGCAGTGCT AACAGTAATTTATACATTTTTAAATGTTCTGAGTATGTTTTGACTGGGCTAGTGTAACAATATACTACCCTGAAAGTGCAGTTTTGATTG TTGTTGGTGTCTTTGGGTCAGGAAAGTGAACTGTGCCAAGAAGTATTTTTCAGTGACATGAATGGATTCCTGTTAATGCAATTGACTGAG AGATTGTGCTTACGCTTTCTTAACTGACAAAAAGAGGCTTTGTCCAACATCAGAATTGTTGAAACTGGTGCTGTTTTCTGTTGCACTGGG ATTCTGATGATCTGGGATTTTCCCTCCTTGGCACAGTAAACACCATGACTGTCTTTATTGAGAATGTCGTCACAGTCCTTTAGTGATAGA TTAGTTAGACCCATGGTTGCAATACCTTTATCTCCCCAAAGAAAATAATCAAAAGAAAGCACAAAAGCTACCCTGTTTGCAGAATATTTC ACTGACATTGATTTGTCATTAATTCTACCAGAGCTGACCTCATTCAGGCTTGATAGAAACAGGTTCCTATGTTTAGGGCAGATCCCTAGC CTCTCGCTCACAGTGAGTCTGCATGTCCTAGATTCTGGTTATTGCTGGAGCATCCATTAAAGTCTACCAAACTCAGGACAGAAGAAGATA GCAGTGGATTTGTAAAAATTTTTAGTTTATAAATTACAGTCATTGGGGAAACACTAGTAAGGTCATGTGATCTTTTGGACCAGGATTTTC TCTCTGTCTTCTCTCTGGGTGTGTGTGTGTGTATGTACAGAAGGGCTACCAGGAAGTGTCAACCATGTTAGATTTTCTGTAGTCTTCCAG AAACAGTGCAGCCCATACAACAGGAATCTTAATTTTCCTCACAGCAAATATAACAGGATGGAACAGTTAGTGTTTTGTTTTCACAAGTGT CCACCACTCCATCTGCCCTGCATGGAGAGGGCTCTCTCACTGCTAGATCTAGGCTGAGCCATCTGGAAGGATCAAAGGGTGTGGGAGTAT CACCCCCTCTCAGGCTGCAGAAGGTCTCGAGGGTGGCGTCACAGCAGGATTTCCGCCTTCTGCATTGCACTGCACAGCCCCATGGAACAT GAGGCACTTGAGGCCTTGCTTCTTGGAGCCTCTGGGGAGCAGAGTAGGTCACTGCCCTCTGGGAGTGTTTTGCAGTAGTTTTGTAAATGT GTTGCTACATAGTCAAGTTCCTTTGTGGCAAAGAAATATTTTGTTTTGATATTAGGAGCCAGCCCATGTAATGCCTCTCAGGCTTGCTTG CTTAGAAGAAAAAAGTCACCCTTTGTGGTTTTTAAGAAAAAAATTCTGTGCAGATCTGTTCCTCCTCCTGCTCCTTCCCTTTTCTCTACA TACAGTGCTCATTGGAGGCTCCTGCTAAACCTTCTTAACCAGAGAAATAATAGGTATTTGTTAGACCTGAGTGTACATTTCACATGTTAT CCTTCACATATTTCTCATTTTCATCTAGTACTTTCTTAATGCCTTTGTTGGAGTCCGCATCCTCATCTTTAAAAAAAAAAAAAAAAAAAC AGCTTAGCCTAAGCCACATTCACTTTTTTTAGTTCACAAAAAGGATTTAATAGCCACAATGTGATTTTTGCCACAACTGTGTGATTTTAA TATTCTCTAATATCAAGGGCGGATTTAGAATTGCAGGAAATACCTGGAGAAATCACAGTGGAATGAATTTTTGCTTTAAGAGAAATGAGA GTTGGCTGTCTCTGTAATTGATAATACAGCTTCATCCTAGTCCCATCTGCATTTCAGAAAATAACCCTCATCTTTACAAAACACAGGACA CTTGTGGGACAGTTAACTCAAGCAGCTATGGGGAGGGAGGAGATTATTGAATGGTGATTAAATAATGCAAATGGCTCTTCTGTTTCTTAA AGACTGTGGAAGAGGTCAGACTGCCCAGTTGAGGTGGGCAGTTCATACTGCTCAGTTGAGGTGGCAGTCATTTATTCTGAGTCCTGTTGG ATAGAGCCTATCTCCTCAAGGCTACAGAGGCTTCCAGGATATGGAGCTGTGCATGTTAATGGCTCAGCCTTGCCTCCATCAGGGCACCTG CCTAACTTGGAGCAAGTGGGAGAGCACCCTAGAGTCATCCTCTGTGCTGTTTCGTGAGTTTTGCAGCGGAGACTTCACCATCCGGAGGAG CTGTGTTTCTGTGTCACTTGGGATATCACCTAAAAATGAAACATTTGATATTTTAAGGTATAAAAAAAAAGTAAATTGGGGAACATTGGC TGCAGTCCCTAAAAGATACTGTTGTCTGTGCATCAGGTTAGCTTGAGGTCACCACAGGTCCTGGGAGCCCAGAGAGTTTAGGCATACTCT CCTTTGGAGGCCAGCAGCCTTTCACAAACCCTGCCTCTAAAAGGGCGGTTTCACATTTGACCATGTTTTTGCATTAGCCTCAGAAACTCT TGTCTTTAGCTGATAACCTTTGAGGGATGTGAGAAGCCTAGTTGGAGCATCTGAGAAAATGATACCTCTCACCTTCAAATTAATCAAATA GTTTGTCCTTCTAGTCCCCTTATAAATTAATAAATGGAGGGCTGGTCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAG GCGGGTGGATCACAAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGT GTAGTGGCACGCTCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGATGTTGCAGTGAGCCGA GATCCCGCCACTGCACTGCAGCCTAGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAAAAGGGAAGGGAATCCCAT TTTGTGATGATTTGGGCACACTACTTGAGCTGAGGCTAGCAGTCACATGATTTTGGCTGTCTCTGACCTGAAGCTTTTGAAGTAAGGTTA TGTCTCTTCCCTGAAGCTTTGTTTATAGTGGTAATTTGGTGAGTTTGAGCTTTGAGCTTGTCTTAGAAAATAAGACTGTCCACCTGGGGA GGGGAGCTTATAGGGAACCCGTGTTAACTCAGAATGCTGAAGAAAGTGCTTTTAGCCAACAAAAGTAAGATTACTATCTAGAAGGTGGAA AGAAGTCATTGCTTCTGTTCCTCCAGCAGTCAGTTGACTCTAGGTTTCCTTTGGTTTATATCCCCAGTTCTTAATACTAAAACTTATTTG ACTTCCTATCAGGAAGCACACAAAAAAAGCGTCATTTAAAACCCTGGATATAGGCTTTAAAGGATACAAAAACAGCAGCATTGTCGTTTT GCCAGGTTCATCACCATTTTGATGTGCTACCCATCCTTCCACCCTCCCTTTCCTGCCCCCAAGCCTCCCAGCCAGGCCAGATGTGAAGAT TCTATTAATCACTGTTTCAGAGAACATTAATTCTTGTATAGAATAATTATCTACTAAATTGCTTATTATCTGTGACTACCTTGCAGAGAA CATCTCAACAGTGCAGTAAAATAGCTCTCCTAGACTTGAGCTTCCAGCCAGGCATTTAGATCACTCTTAAGCCTTTGTGGAATTCTGAGG AAAAAAAGCAAGATGCCTCAATGCCAATGCTGGGCCATAAGATTCTACTCCCCTCCCTGTAGGGTGGGGCGCGTGGCTCAGCTTTGGAAA ATCATTTTGCCAGTAATATTGCCTGTGAATCCCTTTAAGAAGTCGTCCTGATCTGAGCCTGTCTTTCTGAGCACTTTGGTGCTGAATTGA AAATGGTAAGCTAAAGCAGTGACAGATCCACGTAGCCTCTTTAACCTCTTTATTATCTTGCCAAAAAAAAAGTTTCTCAGGTTAAACCTT TGTCTTTAACCTCCCTTTGTTGTGGAGAAAATGTGTCACTAATCAGTGGTCCAAGGGATATCTAGCTTTGGTTACTCAGTTCCTGCAGCA TAACAGATATGACTTATGCCAGGGAAGGTAGAGGCTGATTATGGAGACACCCAGGAACAGGAATAAGAAGGGATAGGTCTGCTCCACGTA GAACCTCCCCAGATCGGAAGTTAAGTCTTGGAGAGTTTCCAAAGTGCTGAAGTAAAAAGGAGACTTGGAGGGCCTTTGCTTAATGAGCAA GAGGCTTGTGTCCTCCCAAGAACATGAGGGAGTTCAGAAGGGAGCTATAGCTCACAGACAGAAACCTGCCCGCTCACCCCATCCCTCGTG ACTGGGAGCATGTTTGCTCAGAATTTTCTAAGAGGACTCTCCCTTCAAAAATCCAATTTGCTCCCAGAATGTTGTTTAGCCTCTGAGAAT CTCACTCTTTCATTTCCATCTGTGAATGGACATAGATGTGTTGCTCAGGGATCAGAAACATCAGAGTCCAGGGCCCAGTGGCATGGTGTT GCATTAGTAGTTAGAAAAGTAATTGGTCAGCTCTACTGTAAAAGAAATAAGTATGTAGTACAGTTTTGTAAATGTCAGGTCTGTTCTATT GTTTTGTGATCTGAAGACTGTCAAACTGGTTGATAATCAAAGAAAAGGTTGGTGGTTAGAATAAGTAAAATTTCAGTTAGAAAGATATAG CTTACCAGTTTTCCATGTGCTTAAGGAAGTCAAGAATATTTCAGGTTGTTGAGAACTGTTGTAAAATGGAATTGAAGCTAGTGTCTCTCA CCTTCTTAGGTGTATCAGAGAGAGGAAGTGGAAGGCCAGTAGTAGCATCTTCATACTTACTTTTGCCAGCCCAGCCTCCATTTCAAAGAC TTTGTCTTCCATCCTATCCAATGACATGGTCAGGGATGGGCTCTGAGGAGGCAGTGAGGCCCCACCTTGGTTTGCTCCACTGTGGTGTGT AGTCTCCAAACAGCTTAAGGGTTTTTAAGTTTTCTCACGATTACCTCCACTCCACTCATCTACTATCAGCATCAGAAAGGTTAACATCCC TGGGACCATTCTACTTATAAAAGAGATGAACTAGTGTGCTTTCTCCCCTTTTCCAGGTGTGCCATCCATATACAATCTCCTCTTGGCCAA GTTCAACAAATGTTTCCAGGGAACCCCGTGGGTTGAGGCAAAGTAGCCAAGATGTATTGAGTTAAGTTTTTCTAGAGGACAAAAGTATTT CTTGTCCCTTTTCCCTCATGCTCATATGTTTTAGCTGAGGCGTAAATGGCCAAGTTGAGTAATATCTGTGGAACTGAGACAGAGAGCCAG GGACCCATGTACCCAGGGACCAGTCCCCTGGGGAATCACACAGTGGCTCAGACTAGACTGCTCTATCCCACCAGAACTCTGCTGCTGTTC ATTTCCATCAGGACCACCCAGGAAAGCAAATAAGTTAGCCTTCTCATCATTAGGTCACCTAATCTCTTGGGTTGCAGGATGAGAGCATAT ATAGATCTCCTGTTTAGAGAGTGTGTTCATAATTGTAGAAAGGGATAGAAAATGGAATAACCAAGAGGCTGTGTCATTTTTTAAGAGGAT GGCAAGGATGACCTCAAATGAGCTCAACAAAACTGGGAATCCAAGGAATGGTGCTTGTAGGGAAAGAGAGGTCAGTTGTGGTCCTTAAAC CTCTTGGCACCTTGTGCGGGTTATAAAACAAGGAGCTGGAGTAAAATTGCCCTTACCCCCAATCCAAATGCTGTCCAGGATTTAGGAGCT ACCCAACCTGTGGTTATATGGTGTTGGTTTCCATTTTTTGTTTGTTTGCTTGTTTCCAAAATAGCCTTGCTTGGTACTGCATGGAAAGTT CAAGCTTTTCTTCTTGCCCGCTCAGGGCTGGCCTCTTCCCCGTGTCTTCACAGCGTCCCTAAGGAAGATTTTTGCAGCACTCTCTGGAGC TGAGGGGAGTGAAATTTGGTCCAGAGAAGGCGGAAGGAAATAGTTTTCCTGTTTCCTTTTCTCGAGGTGGATGTCCTCAGGCTTCCTTCA CACCTCCTTCTCATGGGTGCGGCTGGCAGTACAGTCAGGCTGTGGAGGAGGGCTGAGAAGAAAGGGGCACTGGTCCAGCCCCAGGTTTGG TCTGAGACAGGTACACAGCAGATACCATCCCACCTTCCTCTCTAAAGAACAGGCCAGCCACACATATAACCCTTTCCCTACTTTACTAAT GTATCCCTTATGTGGTACCAGCAATGGAGGACAGGCAGACTTACCCCCTGCCATCTAGAGAGAATGTTGTTATTACCCGTAAAACTTGAC CACCCCCATATCCCACTCCTTTTTGTAAAAACAAATGCTTAAACCTGTGAGCCTGCCGTTCCTTTCTATGTGTTAATCAGTTTCCTTCCA >4874_4874_1_ANO2-NUDT3_ANO2_chr12_5915218_ENST00000327087_NUDT3_chr6_34263462_ENST00000607016_length(amino acids)=428AA_BP=326 MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHD SQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS IFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDN ATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVL -------------------------------------------------------------- >4874_4874_2_ANO2-NUDT3_ANO2_chr12_5915218_ENST00000356134_NUDT3_chr6_34263462_ENST00000607016_length(transcript)=10436nt_BP=1053nt CCAGGCTCCTTCTCTATAAAGTGGGATCTATCATGACCAGCCTACCTTATCAATATAGGAGAGAAAATCTTCATGCCTGAAGATATACCC CTGCTCCCTGGCTCCCCACGCCGGCTGAGCCCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGCGGTGGAGAGAGCACCCGCAGCAGCTCTGTC ATCAACAACTATCTGGATGCCAATGAGCCTGTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGCCACTCGCTGGCTATCGTCTCCAATGGGGAG ACAGGCAAGGAGCCTCATGCTGGGGGCCCAGGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAAAGCCAGGGATCCATCTTTGTCCGGATACAC GCCCCGTGGCAGGTGCTGGCCAGAGAGGCAGAATTCTTGAAGATCAAAGTTCCTACCAAGAAAGAGATGTACGAGATCAAAGCAGGAGGC AGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAA AACCTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGC ATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGGTATTAACTCTCTGATCGCAAACAATATCTATGAG GCTGCCTACCCTCTTCATGACGGTGAATACGATAGTCCAGAGGACGATATGAATGACAGGAAGGCTGGAGTAAAAGGGACATTGGGAAGA TTAGTTGGAATTTTTGAGAACCAGGAGAGGAAGCACAGGACGTATGTCTATGTGCTCATTGTCACTGAAGTGCTGGAAGACTGGGAAGAT TCAGTTAACATTGGAAGGAAGAGGGAATGGTTTAAAATAGAAGACGCCATAAAAGTGCTGCAGTATCACAAACCCGTGCAGGCATCATAT TTTGAAACATTGAGGCAAGGCTACTCAGCCAACAATGGCACCCCAGTCGTGGCCACCACATACTCGGTTTCTGCTCAGAGCTCGATGTCA GGCATCAGATGACTGAAGACTTCCTGTAAGAGAAATGGAAATTGGAAACTAGACTGAAGTGCAAATCTTCCCTCTCACCCTGGCTCTTTC CACTTCTCACAGGCCTCCTCTTTCAAATAAGGCATGGTGGGCAGCAAAGAAAGGGTGTATTGATAATGTTGCTGTTTGGTGTTAAGTGAT GGGGCTTTTTCTTCTGTTTTTATTGAGGGTGGGGGTTGGGTGTGTAATTTGTAAGTACTTTTGTGCATGATCTGTCCCTCCCTCTTCCCA CCCCTGCAGTCCTCTGAAGAGAGGCCAACAGCCTTCCCCTGCCTTGGATTCTGAAGTGTTCCTGTTTGTCTTATCCTGGCCCTGGCCAGA CGTTTTCTTTGATTTTTAATTTTTTTTTTTTATTAAAAGATACCAGTATGAGATGAAAACTTCCAATAATTTGTCCTATAATGTGCTGTA CAGTTCAGTAGAGTGGTCACTTTCACTGCAGTATACATTTATCTACACATTATATATCGGACATATAATATGTAAATAAATGACTTCTAG AAAGAGAAATTTGTTTAATTTTTCAAGGTTTTTTTCTCTTTTAATTTGGGCATTTCTAGAATTGAGAGCCTCACAATTAACATACCTTTT TGTTTTCGATGCTAGTGGCTGGGCAGGTTGCCCTGTCCTTTCTCTATTTCCCAGTCATTGACTGTAGATATGGGAAGAGTTTAGCTACCT TCATAGTGCTCCCAGGACTCATGGCCTTTCCTTCTTTAAGCTGTATTTCCCTGCCCAGAAAGAAACAGGAAGAAACCTTTTTTTATTTTT TTATTTTTTTTTAACCAAGCAAGGAGCAAATGGCCTCAGCCCAGATCTGTAAAAACAATGATAGAAATTGAATTCTGCCCCACATGTTGA CAGTAGAGTTGGAACTGGATTCTTGGGATTACTTATCTAAAAAACTGGAGCATCAGGTCCATTTCTGTTCTGCTGGTTTGGAATCTTTTC CGTAATGCTATTTATTGCCAACAATGGCCTCTCTTTGTGTCCATATATGCCTTACACCGTGCTGACCTGGGTATCATCCATGTGCTCTGA AGCATCCAACTTTACTTTGCAGGTGCATCAATGTAGTCCTGTCCCTGAACTGAGTAACCGTGTTCCTGAAAAGTACACTAGGGAAATTCA CCTGCTTGCTTGTCTTTGTATTGGCATGGCACTTGTGATTGCACCATGGAGCATGCTCAGAGCTATTAAATTGGTCTCCCATCTCCCACC AGGATATGAAAGGTCCATATGGGAGGCCACGTAATCACTTATTACAGTGGTTACATAATACACTGGCTCACTGCAGACTCTCTTGTTTTT TGATACAGTTTCGTGCTGGCTTCATTTGCCAATTGTGTTGTTTAGTTCGGAAGTAAGAGGGTCTTGAGATTGAGGGGTAGGGAGGGCTAC ACTGACTGATCCGTGGCTTAAGACAGGAGATTATCTCTGTACTCCAGTGGCATCTCCTTAGCCAAGATGTGAAATTAAAATCATAGTTCG CCTCATTTAAAAATTCTAATAAAGCACTCAAACTTTGAAAAGCTTTTACTTTTCCCTCCTACTAAAAGAAATGTATGTACCTCATAGCCC TGTGTCATTTAGTGTTCAGCACTTTTGGGAACATCAGTTGGTGAACTTTAAATTTTGCTGTCTACTCACTGGGCACGGTGGCTCACACCT GTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTC TCTACTAAAAATGCAGAAATTAGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCGAGATAATCGCTTGAACCTGGGAGGCAG AGGTTGCAGTGAGCCGAGATTGCACCACTGTCGTCCAGCCTGGGTGATAAGAGTGAAACTCCATCTCAAAAAAAAAAAAAAAAAATTTTT TTTTTTTTTTTTGCTATATACTCTTAGTTTACATCCTCTCCCCCAATCTTCACACACAGAGCCAAAGAGCAGTTATATTCTTGGGATACC ATGATACCTCTGGGAAAGGAATTATATTCCCAAGGAGAGGTCCCATTGGATAAGAACAATACCATGGGACTTGAGTCTGAATGCCAACTT ACTATTCACACATCCTTCTTAAAAACGAACACACTGTTTCTTTTCCTGACCTAGAGCATTCTAAAGTTCTGTTCAAATAAATAAAGGGCA AAATAAAGTAGATTTAACCAAGTGCCAGGTGGAATTCAAAAAACACATTCTTCCAGATAAATTCTACCTTTATGGTATGGATTTGAAAGT ACTTTGCAGGAAAACAGTCAGTACTCTTTAAAAAGGGACTGCAGGGCTGGGTGTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGG CCAAGGCAGGTGGGTCACTTGAGGCCAGGAGTTTGAGACCAGCCTGACCAACATGGCAAAACCCCATCTCTACTAAAATACAAAAATTAG CTGGGCATGATGGTGCACTCCTGTAATCCCAGCTACTTGGTAGGCTGAAGCATGAGAATTGCTTAAACCTGGGAGGCAGAGGTTGCAGTA AGCCAAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCTGTCTTAATAAATAAATAAGAAAATAAAACGGAACTGCAGT GCTAACAGTAATTTATACATTTTTAAATGTTCTGAGTATGTTTTGACTGGGCTAGTGTAACAATATACTACCCTGAAAGTGCAGTTTTGA TTGTTGTTGGTGTCTTTGGGTCAGGAAAGTGAACTGTGCCAAGAAGTATTTTTCAGTGACATGAATGGATTCCTGTTAATGCAATTGACT GAGAGATTGTGCTTACGCTTTCTTAACTGACAAAAAGAGGCTTTGTCCAACATCAGAATTGTTGAAACTGGTGCTGTTTTCTGTTGCACT GGGATTCTGATGATCTGGGATTTTCCCTCCTTGGCACAGTAAACACCATGACTGTCTTTATTGAGAATGTCGTCACAGTCCTTTAGTGAT AGATTAGTTAGACCCATGGTTGCAATACCTTTATCTCCCCAAAGAAAATAATCAAAAGAAAGCACAAAAGCTACCCTGTTTGCAGAATAT TTCACTGACATTGATTTGTCATTAATTCTACCAGAGCTGACCTCATTCAGGCTTGATAGAAACAGGTTCCTATGTTTAGGGCAGATCCCT AGCCTCTCGCTCACAGTGAGTCTGCATGTCCTAGATTCTGGTTATTGCTGGAGCATCCATTAAAGTCTACCAAACTCAGGACAGAAGAAG ATAGCAGTGGATTTGTAAAAATTTTTAGTTTATAAATTACAGTCATTGGGGAAACACTAGTAAGGTCATGTGATCTTTTGGACCAGGATT TTCTCTCTGTCTTCTCTCTGGGTGTGTGTGTGTGTATGTACAGAAGGGCTACCAGGAAGTGTCAACCATGTTAGATTTTCTGTAGTCTTC CAGAAACAGTGCAGCCCATACAACAGGAATCTTAATTTTCCTCACAGCAAATATAACAGGATGGAACAGTTAGTGTTTTGTTTTCACAAG TGTCCACCACTCCATCTGCCCTGCATGGAGAGGGCTCTCTCACTGCTAGATCTAGGCTGAGCCATCTGGAAGGATCAAAGGGTGTGGGAG TATCACCCCCTCTCAGGCTGCAGAAGGTCTCGAGGGTGGCGTCACAGCAGGATTTCCGCCTTCTGCATTGCACTGCACAGCCCCATGGAA CATGAGGCACTTGAGGCCTTGCTTCTTGGAGCCTCTGGGGAGCAGAGTAGGTCACTGCCCTCTGGGAGTGTTTTGCAGTAGTTTTGTAAA TGTGTTGCTACATAGTCAAGTTCCTTTGTGGCAAAGAAATATTTTGTTTTGATATTAGGAGCCAGCCCATGTAATGCCTCTCAGGCTTGC TTGCTTAGAAGAAAAAAGTCACCCTTTGTGGTTTTTAAGAAAAAAATTCTGTGCAGATCTGTTCCTCCTCCTGCTCCTTCCCTTTTCTCT ACATACAGTGCTCATTGGAGGCTCCTGCTAAACCTTCTTAACCAGAGAAATAATAGGTATTTGTTAGACCTGAGTGTACATTTCACATGT TATCCTTCACATATTTCTCATTTTCATCTAGTACTTTCTTAATGCCTTTGTTGGAGTCCGCATCCTCATCTTTAAAAAAAAAAAAAAAAA AACAGCTTAGCCTAAGCCACATTCACTTTTTTTAGTTCACAAAAAGGATTTAATAGCCACAATGTGATTTTTGCCACAACTGTGTGATTT TAATATTCTCTAATATCAAGGGCGGATTTAGAATTGCAGGAAATACCTGGAGAAATCACAGTGGAATGAATTTTTGCTTTAAGAGAAATG AGAGTTGGCTGTCTCTGTAATTGATAATACAGCTTCATCCTAGTCCCATCTGCATTTCAGAAAATAACCCTCATCTTTACAAAACACAGG ACACTTGTGGGACAGTTAACTCAAGCAGCTATGGGGAGGGAGGAGATTATTGAATGGTGATTAAATAATGCAAATGGCTCTTCTGTTTCT TAAAGACTGTGGAAGAGGTCAGACTGCCCAGTTGAGGTGGGCAGTTCATACTGCTCAGTTGAGGTGGCAGTCATTTATTCTGAGTCCTGT TGGATAGAGCCTATCTCCTCAAGGCTACAGAGGCTTCCAGGATATGGAGCTGTGCATGTTAATGGCTCAGCCTTGCCTCCATCAGGGCAC CTGCCTAACTTGGAGCAAGTGGGAGAGCACCCTAGAGTCATCCTCTGTGCTGTTTCGTGAGTTTTGCAGCGGAGACTTCACCATCCGGAG GAGCTGTGTTTCTGTGTCACTTGGGATATCACCTAAAAATGAAACATTTGATATTTTAAGGTATAAAAAAAAAGTAAATTGGGGAACATT GGCTGCAGTCCCTAAAAGATACTGTTGTCTGTGCATCAGGTTAGCTTGAGGTCACCACAGGTCCTGGGAGCCCAGAGAGTTTAGGCATAC TCTCCTTTGGAGGCCAGCAGCCTTTCACAAACCCTGCCTCTAAAAGGGCGGTTTCACATTTGACCATGTTTTTGCATTAGCCTCAGAAAC TCTTGTCTTTAGCTGATAACCTTTGAGGGATGTGAGAAGCCTAGTTGGAGCATCTGAGAAAATGATACCTCTCACCTTCAAATTAATCAA ATAGTTTGTCCTTCTAGTCCCCTTATAAATTAATAAATGGAGGGCTGGTCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCC GAGGCGGGTGGATCACAAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCA GGTGTAGTGGCACGCTCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGATGTTGCAGTGAGC CGAGATCCCGCCACTGCACTGCAGCCTAGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAAAAGGGAAGGGAATCC CATTTTGTGATGATTTGGGCACACTACTTGAGCTGAGGCTAGCAGTCACATGATTTTGGCTGTCTCTGACCTGAAGCTTTTGAAGTAAGG TTATGTCTCTTCCCTGAAGCTTTGTTTATAGTGGTAATTTGGTGAGTTTGAGCTTTGAGCTTGTCTTAGAAAATAAGACTGTCCACCTGG GGAGGGGAGCTTATAGGGAACCCGTGTTAACTCAGAATGCTGAAGAAAGTGCTTTTAGCCAACAAAAGTAAGATTACTATCTAGAAGGTG GAAAGAAGTCATTGCTTCTGTTCCTCCAGCAGTCAGTTGACTCTAGGTTTCCTTTGGTTTATATCCCCAGTTCTTAATACTAAAACTTAT TTGACTTCCTATCAGGAAGCACACAAAAAAAGCGTCATTTAAAACCCTGGATATAGGCTTTAAAGGATACAAAAACAGCAGCATTGTCGT TTTGCCAGGTTCATCACCATTTTGATGTGCTACCCATCCTTCCACCCTCCCTTTCCTGCCCCCAAGCCTCCCAGCCAGGCCAGATGTGAA GATTCTATTAATCACTGTTTCAGAGAACATTAATTCTTGTATAGAATAATTATCTACTAAATTGCTTATTATCTGTGACTACCTTGCAGA GAACATCTCAACAGTGCAGTAAAATAGCTCTCCTAGACTTGAGCTTCCAGCCAGGCATTTAGATCACTCTTAAGCCTTTGTGGAATTCTG AGGAAAAAAAGCAAGATGCCTCAATGCCAATGCTGGGCCATAAGATTCTACTCCCCTCCCTGTAGGGTGGGGCGCGTGGCTCAGCTTTGG AAAATCATTTTGCCAGTAATATTGCCTGTGAATCCCTTTAAGAAGTCGTCCTGATCTGAGCCTGTCTTTCTGAGCACTTTGGTGCTGAAT TGAAAATGGTAAGCTAAAGCAGTGACAGATCCACGTAGCCTCTTTAACCTCTTTATTATCTTGCCAAAAAAAAAGTTTCTCAGGTTAAAC CTTTGTCTTTAACCTCCCTTTGTTGTGGAGAAAATGTGTCACTAATCAGTGGTCCAAGGGATATCTAGCTTTGGTTACTCAGTTCCTGCA GCATAACAGATATGACTTATGCCAGGGAAGGTAGAGGCTGATTATGGAGACACCCAGGAACAGGAATAAGAAGGGATAGGTCTGCTCCAC GTAGAACCTCCCCAGATCGGAAGTTAAGTCTTGGAGAGTTTCCAAAGTGCTGAAGTAAAAAGGAGACTTGGAGGGCCTTTGCTTAATGAG CAAGAGGCTTGTGTCCTCCCAAGAACATGAGGGAGTTCAGAAGGGAGCTATAGCTCACAGACAGAAACCTGCCCGCTCACCCCATCCCTC GTGACTGGGAGCATGTTTGCTCAGAATTTTCTAAGAGGACTCTCCCTTCAAAAATCCAATTTGCTCCCAGAATGTTGTTTAGCCTCTGAG AATCTCACTCTTTCATTTCCATCTGTGAATGGACATAGATGTGTTGCTCAGGGATCAGAAACATCAGAGTCCAGGGCCCAGTGGCATGGT GTTGCATTAGTAGTTAGAAAAGTAATTGGTCAGCTCTACTGTAAAAGAAATAAGTATGTAGTACAGTTTTGTAAATGTCAGGTCTGTTCT ATTGTTTTGTGATCTGAAGACTGTCAAACTGGTTGATAATCAAAGAAAAGGTTGGTGGTTAGAATAAGTAAAATTTCAGTTAGAAAGATA TAGCTTACCAGTTTTCCATGTGCTTAAGGAAGTCAAGAATATTTCAGGTTGTTGAGAACTGTTGTAAAATGGAATTGAAGCTAGTGTCTC TCACCTTCTTAGGTGTATCAGAGAGAGGAAGTGGAAGGCCAGTAGTAGCATCTTCATACTTACTTTTGCCAGCCCAGCCTCCATTTCAAA GACTTTGTCTTCCATCCTATCCAATGACATGGTCAGGGATGGGCTCTGAGGAGGCAGTGAGGCCCCACCTTGGTTTGCTCCACTGTGGTG TGTAGTCTCCAAACAGCTTAAGGGTTTTTAAGTTTTCTCACGATTACCTCCACTCCACTCATCTACTATCAGCATCAGAAAGGTTAACAT CCCTGGGACCATTCTACTTATAAAAGAGATGAACTAGTGTGCTTTCTCCCCTTTTCCAGGTGTGCCATCCATATACAATCTCCTCTTGGC CAAGTTCAACAAATGTTTCCAGGGAACCCCGTGGGTTGAGGCAAAGTAGCCAAGATGTATTGAGTTAAGTTTTTCTAGAGGACAAAAGTA TTTCTTGTCCCTTTTCCCTCATGCTCATATGTTTTAGCTGAGGCGTAAATGGCCAAGTTGAGTAATATCTGTGGAACTGAGACAGAGAGC CAGGGACCCATGTACCCAGGGACCAGTCCCCTGGGGAATCACACAGTGGCTCAGACTAGACTGCTCTATCCCACCAGAACTCTGCTGCTG TTCATTTCCATCAGGACCACCCAGGAAAGCAAATAAGTTAGCCTTCTCATCATTAGGTCACCTAATCTCTTGGGTTGCAGGATGAGAGCA TATATAGATCTCCTGTTTAGAGAGTGTGTTCATAATTGTAGAAAGGGATAGAAAATGGAATAACCAAGAGGCTGTGTCATTTTTTAAGAG GATGGCAAGGATGACCTCAAATGAGCTCAACAAAACTGGGAATCCAAGGAATGGTGCTTGTAGGGAAAGAGAGGTCAGTTGTGGTCCTTA AACCTCTTGGCACCTTGTGCGGGTTATAAAACAAGGAGCTGGAGTAAAATTGCCCTTACCCCCAATCCAAATGCTGTCCAGGATTTAGGA GCTACCCAACCTGTGGTTATATGGTGTTGGTTTCCATTTTTTGTTTGTTTGCTTGTTTCCAAAATAGCCTTGCTTGGTACTGCATGGAAA GTTCAAGCTTTTCTTCTTGCCCGCTCAGGGCTGGCCTCTTCCCCGTGTCTTCACAGCGTCCCTAAGGAAGATTTTTGCAGCACTCTCTGG AGCTGAGGGGAGTGAAATTTGGTCCAGAGAAGGCGGAAGGAAATAGTTTTCCTGTTTCCTTTTCTCGAGGTGGATGTCCTCAGGCTTCCT TCACACCTCCTTCTCATGGGTGCGGCTGGCAGTACAGTCAGGCTGTGGAGGAGGGCTGAGAAGAAAGGGGCACTGGTCCAGCCCCAGGTT TGGTCTGAGACAGGTACACAGCAGATACCATCCCACCTTCCTCTCTAAAGAACAGGCCAGCCACACATATAACCCTTTCCCTACTTTACT AATGTATCCCTTATGTGGTACCAGCAATGGAGGACAGGCAGACTTACCCCCTGCCATCTAGAGAGAATGTTGTTATTACCCGTAAAACTT GACCACCCCCATATCCCACTCCTTTTTGTAAAAACAAATGCTTAAACCTGTGAGCCTGCCGTTCCTTTCTATGTGTTAATCAGTTTCCTT >4874_4874_2_ANO2-NUDT3_ANO2_chr12_5915218_ENST00000356134_NUDT3_chr6_34263462_ENST00000607016_length(amino acids)=429AA_BP=327 MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHD SQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS IFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFD NATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEV -------------------------------------------------------------- >4874_4874_3_ANO2-NUDT3_ANO2_chr12_5915218_ENST00000546188_NUDT3_chr6_34263462_ENST00000607016_length(transcript)=10436nt_BP=1053nt CCAGGCTCCTTCTCTATAAAGTGGGATCTATCATGACCAGCCTACCTTATCAATATAGGAGAGAAAATCTTCATGCCTGAAGATATACCC CTGCTCCCTGGCTCCCCACGCCGGCTGAGCCCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGCGGTGGAGAGAGCACCCGCAGCAGCTCTGTC ATCAACAACTATCTGGATGCCAATGAGCCTGTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGCCACTCGCTGGCTATCGTCTCCAATGGGGAG ACAGGCAAGGAGCCTCATGCTGGGGGCCCAGGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAAAGCCAGGGATCCATCTTTGTCCGGATACAC GCCCCGTGGCAGGTGCTGGCCAGAGAGGCAGAATTCTTGAAGATCAAAGTTCCTACCAAGAAAGAGATGTACGAGATCAAAGCAGGAGGC AGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAA AACCTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGC ATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGGTATTAACTCTCTGATCGCAAACAATATCTATGAG GCTGCCTACCCTCTTCATGACGGTGAATACGATAGTCCAGAGGACGATATGAATGACAGGAAGGCTGGAGTAAAAGGGACATTGGGAAGA TTAGTTGGAATTTTTGAGAACCAGGAGAGGAAGCACAGGACGTATGTCTATGTGCTCATTGTCACTGAAGTGCTGGAAGACTGGGAAGAT TCAGTTAACATTGGAAGGAAGAGGGAATGGTTTAAAATAGAAGACGCCATAAAAGTGCTGCAGTATCACAAACCCGTGCAGGCATCATAT TTTGAAACATTGAGGCAAGGCTACTCAGCCAACAATGGCACCCCAGTCGTGGCCACCACATACTCGGTTTCTGCTCAGAGCTCGATGTCA GGCATCAGATGACTGAAGACTTCCTGTAAGAGAAATGGAAATTGGAAACTAGACTGAAGTGCAAATCTTCCCTCTCACCCTGGCTCTTTC CACTTCTCACAGGCCTCCTCTTTCAAATAAGGCATGGTGGGCAGCAAAGAAAGGGTGTATTGATAATGTTGCTGTTTGGTGTTAAGTGAT GGGGCTTTTTCTTCTGTTTTTATTGAGGGTGGGGGTTGGGTGTGTAATTTGTAAGTACTTTTGTGCATGATCTGTCCCTCCCTCTTCCCA CCCCTGCAGTCCTCTGAAGAGAGGCCAACAGCCTTCCCCTGCCTTGGATTCTGAAGTGTTCCTGTTTGTCTTATCCTGGCCCTGGCCAGA CGTTTTCTTTGATTTTTAATTTTTTTTTTTTATTAAAAGATACCAGTATGAGATGAAAACTTCCAATAATTTGTCCTATAATGTGCTGTA CAGTTCAGTAGAGTGGTCACTTTCACTGCAGTATACATTTATCTACACATTATATATCGGACATATAATATGTAAATAAATGACTTCTAG AAAGAGAAATTTGTTTAATTTTTCAAGGTTTTTTTCTCTTTTAATTTGGGCATTTCTAGAATTGAGAGCCTCACAATTAACATACCTTTT TGTTTTCGATGCTAGTGGCTGGGCAGGTTGCCCTGTCCTTTCTCTATTTCCCAGTCATTGACTGTAGATATGGGAAGAGTTTAGCTACCT TCATAGTGCTCCCAGGACTCATGGCCTTTCCTTCTTTAAGCTGTATTTCCCTGCCCAGAAAGAAACAGGAAGAAACCTTTTTTTATTTTT TTATTTTTTTTTAACCAAGCAAGGAGCAAATGGCCTCAGCCCAGATCTGTAAAAACAATGATAGAAATTGAATTCTGCCCCACATGTTGA CAGTAGAGTTGGAACTGGATTCTTGGGATTACTTATCTAAAAAACTGGAGCATCAGGTCCATTTCTGTTCTGCTGGTTTGGAATCTTTTC CGTAATGCTATTTATTGCCAACAATGGCCTCTCTTTGTGTCCATATATGCCTTACACCGTGCTGACCTGGGTATCATCCATGTGCTCTGA AGCATCCAACTTTACTTTGCAGGTGCATCAATGTAGTCCTGTCCCTGAACTGAGTAACCGTGTTCCTGAAAAGTACACTAGGGAAATTCA CCTGCTTGCTTGTCTTTGTATTGGCATGGCACTTGTGATTGCACCATGGAGCATGCTCAGAGCTATTAAATTGGTCTCCCATCTCCCACC AGGATATGAAAGGTCCATATGGGAGGCCACGTAATCACTTATTACAGTGGTTACATAATACACTGGCTCACTGCAGACTCTCTTGTTTTT TGATACAGTTTCGTGCTGGCTTCATTTGCCAATTGTGTTGTTTAGTTCGGAAGTAAGAGGGTCTTGAGATTGAGGGGTAGGGAGGGCTAC ACTGACTGATCCGTGGCTTAAGACAGGAGATTATCTCTGTACTCCAGTGGCATCTCCTTAGCCAAGATGTGAAATTAAAATCATAGTTCG CCTCATTTAAAAATTCTAATAAAGCACTCAAACTTTGAAAAGCTTTTACTTTTCCCTCCTACTAAAAGAAATGTATGTACCTCATAGCCC TGTGTCATTTAGTGTTCAGCACTTTTGGGAACATCAGTTGGTGAACTTTAAATTTTGCTGTCTACTCACTGGGCACGGTGGCTCACACCT GTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTC TCTACTAAAAATGCAGAAATTAGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCGAGATAATCGCTTGAACCTGGGAGGCAG AGGTTGCAGTGAGCCGAGATTGCACCACTGTCGTCCAGCCTGGGTGATAAGAGTGAAACTCCATCTCAAAAAAAAAAAAAAAAAATTTTT TTTTTTTTTTTTGCTATATACTCTTAGTTTACATCCTCTCCCCCAATCTTCACACACAGAGCCAAAGAGCAGTTATATTCTTGGGATACC ATGATACCTCTGGGAAAGGAATTATATTCCCAAGGAGAGGTCCCATTGGATAAGAACAATACCATGGGACTTGAGTCTGAATGCCAACTT ACTATTCACACATCCTTCTTAAAAACGAACACACTGTTTCTTTTCCTGACCTAGAGCATTCTAAAGTTCTGTTCAAATAAATAAAGGGCA AAATAAAGTAGATTTAACCAAGTGCCAGGTGGAATTCAAAAAACACATTCTTCCAGATAAATTCTACCTTTATGGTATGGATTTGAAAGT ACTTTGCAGGAAAACAGTCAGTACTCTTTAAAAAGGGACTGCAGGGCTGGGTGTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGG CCAAGGCAGGTGGGTCACTTGAGGCCAGGAGTTTGAGACCAGCCTGACCAACATGGCAAAACCCCATCTCTACTAAAATACAAAAATTAG CTGGGCATGATGGTGCACTCCTGTAATCCCAGCTACTTGGTAGGCTGAAGCATGAGAATTGCTTAAACCTGGGAGGCAGAGGTTGCAGTA AGCCAAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCTGTCTTAATAAATAAATAAGAAAATAAAACGGAACTGCAGT GCTAACAGTAATTTATACATTTTTAAATGTTCTGAGTATGTTTTGACTGGGCTAGTGTAACAATATACTACCCTGAAAGTGCAGTTTTGA TTGTTGTTGGTGTCTTTGGGTCAGGAAAGTGAACTGTGCCAAGAAGTATTTTTCAGTGACATGAATGGATTCCTGTTAATGCAATTGACT GAGAGATTGTGCTTACGCTTTCTTAACTGACAAAAAGAGGCTTTGTCCAACATCAGAATTGTTGAAACTGGTGCTGTTTTCTGTTGCACT GGGATTCTGATGATCTGGGATTTTCCCTCCTTGGCACAGTAAACACCATGACTGTCTTTATTGAGAATGTCGTCACAGTCCTTTAGTGAT AGATTAGTTAGACCCATGGTTGCAATACCTTTATCTCCCCAAAGAAAATAATCAAAAGAAAGCACAAAAGCTACCCTGTTTGCAGAATAT TTCACTGACATTGATTTGTCATTAATTCTACCAGAGCTGACCTCATTCAGGCTTGATAGAAACAGGTTCCTATGTTTAGGGCAGATCCCT AGCCTCTCGCTCACAGTGAGTCTGCATGTCCTAGATTCTGGTTATTGCTGGAGCATCCATTAAAGTCTACCAAACTCAGGACAGAAGAAG ATAGCAGTGGATTTGTAAAAATTTTTAGTTTATAAATTACAGTCATTGGGGAAACACTAGTAAGGTCATGTGATCTTTTGGACCAGGATT TTCTCTCTGTCTTCTCTCTGGGTGTGTGTGTGTGTATGTACAGAAGGGCTACCAGGAAGTGTCAACCATGTTAGATTTTCTGTAGTCTTC CAGAAACAGTGCAGCCCATACAACAGGAATCTTAATTTTCCTCACAGCAAATATAACAGGATGGAACAGTTAGTGTTTTGTTTTCACAAG TGTCCACCACTCCATCTGCCCTGCATGGAGAGGGCTCTCTCACTGCTAGATCTAGGCTGAGCCATCTGGAAGGATCAAAGGGTGTGGGAG TATCACCCCCTCTCAGGCTGCAGAAGGTCTCGAGGGTGGCGTCACAGCAGGATTTCCGCCTTCTGCATTGCACTGCACAGCCCCATGGAA CATGAGGCACTTGAGGCCTTGCTTCTTGGAGCCTCTGGGGAGCAGAGTAGGTCACTGCCCTCTGGGAGTGTTTTGCAGTAGTTTTGTAAA TGTGTTGCTACATAGTCAAGTTCCTTTGTGGCAAAGAAATATTTTGTTTTGATATTAGGAGCCAGCCCATGTAATGCCTCTCAGGCTTGC TTGCTTAGAAGAAAAAAGTCACCCTTTGTGGTTTTTAAGAAAAAAATTCTGTGCAGATCTGTTCCTCCTCCTGCTCCTTCCCTTTTCTCT ACATACAGTGCTCATTGGAGGCTCCTGCTAAACCTTCTTAACCAGAGAAATAATAGGTATTTGTTAGACCTGAGTGTACATTTCACATGT TATCCTTCACATATTTCTCATTTTCATCTAGTACTTTCTTAATGCCTTTGTTGGAGTCCGCATCCTCATCTTTAAAAAAAAAAAAAAAAA AACAGCTTAGCCTAAGCCACATTCACTTTTTTTAGTTCACAAAAAGGATTTAATAGCCACAATGTGATTTTTGCCACAACTGTGTGATTT TAATATTCTCTAATATCAAGGGCGGATTTAGAATTGCAGGAAATACCTGGAGAAATCACAGTGGAATGAATTTTTGCTTTAAGAGAAATG AGAGTTGGCTGTCTCTGTAATTGATAATACAGCTTCATCCTAGTCCCATCTGCATTTCAGAAAATAACCCTCATCTTTACAAAACACAGG ACACTTGTGGGACAGTTAACTCAAGCAGCTATGGGGAGGGAGGAGATTATTGAATGGTGATTAAATAATGCAAATGGCTCTTCTGTTTCT TAAAGACTGTGGAAGAGGTCAGACTGCCCAGTTGAGGTGGGCAGTTCATACTGCTCAGTTGAGGTGGCAGTCATTTATTCTGAGTCCTGT TGGATAGAGCCTATCTCCTCAAGGCTACAGAGGCTTCCAGGATATGGAGCTGTGCATGTTAATGGCTCAGCCTTGCCTCCATCAGGGCAC CTGCCTAACTTGGAGCAAGTGGGAGAGCACCCTAGAGTCATCCTCTGTGCTGTTTCGTGAGTTTTGCAGCGGAGACTTCACCATCCGGAG GAGCTGTGTTTCTGTGTCACTTGGGATATCACCTAAAAATGAAACATTTGATATTTTAAGGTATAAAAAAAAAGTAAATTGGGGAACATT GGCTGCAGTCCCTAAAAGATACTGTTGTCTGTGCATCAGGTTAGCTTGAGGTCACCACAGGTCCTGGGAGCCCAGAGAGTTTAGGCATAC TCTCCTTTGGAGGCCAGCAGCCTTTCACAAACCCTGCCTCTAAAAGGGCGGTTTCACATTTGACCATGTTTTTGCATTAGCCTCAGAAAC TCTTGTCTTTAGCTGATAACCTTTGAGGGATGTGAGAAGCCTAGTTGGAGCATCTGAGAAAATGATACCTCTCACCTTCAAATTAATCAA ATAGTTTGTCCTTCTAGTCCCCTTATAAATTAATAAATGGAGGGCTGGTCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCC GAGGCGGGTGGATCACAAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCA GGTGTAGTGGCACGCTCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGATGTTGCAGTGAGC CGAGATCCCGCCACTGCACTGCAGCCTAGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAAAAGGGAAGGGAATCC CATTTTGTGATGATTTGGGCACACTACTTGAGCTGAGGCTAGCAGTCACATGATTTTGGCTGTCTCTGACCTGAAGCTTTTGAAGTAAGG TTATGTCTCTTCCCTGAAGCTTTGTTTATAGTGGTAATTTGGTGAGTTTGAGCTTTGAGCTTGTCTTAGAAAATAAGACTGTCCACCTGG GGAGGGGAGCTTATAGGGAACCCGTGTTAACTCAGAATGCTGAAGAAAGTGCTTTTAGCCAACAAAAGTAAGATTACTATCTAGAAGGTG GAAAGAAGTCATTGCTTCTGTTCCTCCAGCAGTCAGTTGACTCTAGGTTTCCTTTGGTTTATATCCCCAGTTCTTAATACTAAAACTTAT TTGACTTCCTATCAGGAAGCACACAAAAAAAGCGTCATTTAAAACCCTGGATATAGGCTTTAAAGGATACAAAAACAGCAGCATTGTCGT TTTGCCAGGTTCATCACCATTTTGATGTGCTACCCATCCTTCCACCCTCCCTTTCCTGCCCCCAAGCCTCCCAGCCAGGCCAGATGTGAA GATTCTATTAATCACTGTTTCAGAGAACATTAATTCTTGTATAGAATAATTATCTACTAAATTGCTTATTATCTGTGACTACCTTGCAGA GAACATCTCAACAGTGCAGTAAAATAGCTCTCCTAGACTTGAGCTTCCAGCCAGGCATTTAGATCACTCTTAAGCCTTTGTGGAATTCTG AGGAAAAAAAGCAAGATGCCTCAATGCCAATGCTGGGCCATAAGATTCTACTCCCCTCCCTGTAGGGTGGGGCGCGTGGCTCAGCTTTGG AAAATCATTTTGCCAGTAATATTGCCTGTGAATCCCTTTAAGAAGTCGTCCTGATCTGAGCCTGTCTTTCTGAGCACTTTGGTGCTGAAT TGAAAATGGTAAGCTAAAGCAGTGACAGATCCACGTAGCCTCTTTAACCTCTTTATTATCTTGCCAAAAAAAAAGTTTCTCAGGTTAAAC CTTTGTCTTTAACCTCCCTTTGTTGTGGAGAAAATGTGTCACTAATCAGTGGTCCAAGGGATATCTAGCTTTGGTTACTCAGTTCCTGCA GCATAACAGATATGACTTATGCCAGGGAAGGTAGAGGCTGATTATGGAGACACCCAGGAACAGGAATAAGAAGGGATAGGTCTGCTCCAC GTAGAACCTCCCCAGATCGGAAGTTAAGTCTTGGAGAGTTTCCAAAGTGCTGAAGTAAAAAGGAGACTTGGAGGGCCTTTGCTTAATGAG CAAGAGGCTTGTGTCCTCCCAAGAACATGAGGGAGTTCAGAAGGGAGCTATAGCTCACAGACAGAAACCTGCCCGCTCACCCCATCCCTC GTGACTGGGAGCATGTTTGCTCAGAATTTTCTAAGAGGACTCTCCCTTCAAAAATCCAATTTGCTCCCAGAATGTTGTTTAGCCTCTGAG AATCTCACTCTTTCATTTCCATCTGTGAATGGACATAGATGTGTTGCTCAGGGATCAGAAACATCAGAGTCCAGGGCCCAGTGGCATGGT GTTGCATTAGTAGTTAGAAAAGTAATTGGTCAGCTCTACTGTAAAAGAAATAAGTATGTAGTACAGTTTTGTAAATGTCAGGTCTGTTCT ATTGTTTTGTGATCTGAAGACTGTCAAACTGGTTGATAATCAAAGAAAAGGTTGGTGGTTAGAATAAGTAAAATTTCAGTTAGAAAGATA TAGCTTACCAGTTTTCCATGTGCTTAAGGAAGTCAAGAATATTTCAGGTTGTTGAGAACTGTTGTAAAATGGAATTGAAGCTAGTGTCTC TCACCTTCTTAGGTGTATCAGAGAGAGGAAGTGGAAGGCCAGTAGTAGCATCTTCATACTTACTTTTGCCAGCCCAGCCTCCATTTCAAA GACTTTGTCTTCCATCCTATCCAATGACATGGTCAGGGATGGGCTCTGAGGAGGCAGTGAGGCCCCACCTTGGTTTGCTCCACTGTGGTG TGTAGTCTCCAAACAGCTTAAGGGTTTTTAAGTTTTCTCACGATTACCTCCACTCCACTCATCTACTATCAGCATCAGAAAGGTTAACAT CCCTGGGACCATTCTACTTATAAAAGAGATGAACTAGTGTGCTTTCTCCCCTTTTCCAGGTGTGCCATCCATATACAATCTCCTCTTGGC CAAGTTCAACAAATGTTTCCAGGGAACCCCGTGGGTTGAGGCAAAGTAGCCAAGATGTATTGAGTTAAGTTTTTCTAGAGGACAAAAGTA TTTCTTGTCCCTTTTCCCTCATGCTCATATGTTTTAGCTGAGGCGTAAATGGCCAAGTTGAGTAATATCTGTGGAACTGAGACAGAGAGC CAGGGACCCATGTACCCAGGGACCAGTCCCCTGGGGAATCACACAGTGGCTCAGACTAGACTGCTCTATCCCACCAGAACTCTGCTGCTG TTCATTTCCATCAGGACCACCCAGGAAAGCAAATAAGTTAGCCTTCTCATCATTAGGTCACCTAATCTCTTGGGTTGCAGGATGAGAGCA TATATAGATCTCCTGTTTAGAGAGTGTGTTCATAATTGTAGAAAGGGATAGAAAATGGAATAACCAAGAGGCTGTGTCATTTTTTAAGAG GATGGCAAGGATGACCTCAAATGAGCTCAACAAAACTGGGAATCCAAGGAATGGTGCTTGTAGGGAAAGAGAGGTCAGTTGTGGTCCTTA AACCTCTTGGCACCTTGTGCGGGTTATAAAACAAGGAGCTGGAGTAAAATTGCCCTTACCCCCAATCCAAATGCTGTCCAGGATTTAGGA GCTACCCAACCTGTGGTTATATGGTGTTGGTTTCCATTTTTTGTTTGTTTGCTTGTTTCCAAAATAGCCTTGCTTGGTACTGCATGGAAA GTTCAAGCTTTTCTTCTTGCCCGCTCAGGGCTGGCCTCTTCCCCGTGTCTTCACAGCGTCCCTAAGGAAGATTTTTGCAGCACTCTCTGG AGCTGAGGGGAGTGAAATTTGGTCCAGAGAAGGCGGAAGGAAATAGTTTTCCTGTTTCCTTTTCTCGAGGTGGATGTCCTCAGGCTTCCT TCACACCTCCTTCTCATGGGTGCGGCTGGCAGTACAGTCAGGCTGTGGAGGAGGGCTGAGAAGAAAGGGGCACTGGTCCAGCCCCAGGTT TGGTCTGAGACAGGTACACAGCAGATACCATCCCACCTTCCTCTCTAAAGAACAGGCCAGCCACACATATAACCCTTTCCCTACTTTACT AATGTATCCCTTATGTGGTACCAGCAATGGAGGACAGGCAGACTTACCCCCTGCCATCTAGAGAGAATGTTGTTATTACCCGTAAAACTT GACCACCCCCATATCCCACTCCTTTTTGTAAAAACAAATGCTTAAACCTGTGAGCCTGCCGTTCCTTTCTATGTGTTAATCAGTTTCCTT >4874_4874_3_ANO2-NUDT3_ANO2_chr12_5915218_ENST00000546188_NUDT3_chr6_34263462_ENST00000607016_length(amino acids)=429AA_BP=327 MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHD SQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS IFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFD NATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ANO2-NUDT3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ANO2-NUDT3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ANO2-NUDT3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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