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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANO2-DCP1B (FusionGDB2 ID:HG57101TG196513)

Fusion Gene Summary for ANO2-DCP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ANO2-DCP1B
Fusion gene ID: hg57101tg196513
HgeneTgene
Gene symbol

ANO2

DCP1B

Gene ID

57101

196513

Gene nameanoctamin 2decapping mRNA 1B
SynonymsC12orf3|TMEM16BDCP1
Cytomap('ANO2')('DCP1B')

12p13.31

12p13.33

Type of geneprotein-codingprotein-coding
Descriptionanoctamin-2anoctamin 2, calcium activated chloride channeltransmembrane protein 16B (eight membrane-spanning domains)mRNA-decapping enzyme 1BDCP1 decapping enzyme homolog Bdecapping enzyme hDcp1b
Modification date2020032920200328
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000327087, ENST00000356134, 
ENST00000546188, ENST00000538154, 
Fusion gene scores* DoF score8 X 9 X 6=4325 X 4 X 5=100
# samples 97
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANO2 [Title/Abstract] AND DCP1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANO2(5936935)-DCP1B(2077076), # samples:2
Anticipated loss of major functional domain due to fusion event.ANO2-DCP1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANO2-DCP1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANO2-DCP1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANO2-DCP1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DCP1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-2077-01AANO2chr12

5936935

-DCP1Bchr12

2077076

-


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Fusion Gene ORF analysis for ANO2-DCP1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000327087ENST00000540622ANO2chr12

5936935

-DCP1Bchr12

2077076

-
5CDS-intronENST00000327087ENST00000541700ANO2chr12

5936935

-DCP1Bchr12

2077076

-
5CDS-intronENST00000356134ENST00000540622ANO2chr12

5936935

-DCP1Bchr12

2077076

-
5CDS-intronENST00000356134ENST00000541700ANO2chr12

5936935

-DCP1Bchr12

2077076

-
5CDS-intronENST00000546188ENST00000540622ANO2chr12

5936935

-DCP1Bchr12

2077076

-
5CDS-intronENST00000546188ENST00000541700ANO2chr12

5936935

-DCP1Bchr12

2077076

-
In-frameENST00000327087ENST00000280665ANO2chr12

5936935

-DCP1Bchr12

2077076

-
In-frameENST00000327087ENST00000397173ANO2chr12

5936935

-DCP1Bchr12

2077076

-
In-frameENST00000356134ENST00000280665ANO2chr12

5936935

-DCP1Bchr12

2077076

-
In-frameENST00000356134ENST00000397173ANO2chr12

5936935

-DCP1Bchr12

2077076

-
In-frameENST00000546188ENST00000280665ANO2chr12

5936935

-DCP1Bchr12

2077076

-
In-frameENST00000546188ENST00000397173ANO2chr12

5936935

-DCP1Bchr12

2077076

-
intron-3CDSENST00000538154ENST00000280665ANO2chr12

5936935

-DCP1Bchr12

2077076

-
intron-3CDSENST00000538154ENST00000397173ANO2chr12

5936935

-DCP1Bchr12

2077076

-
intron-intronENST00000538154ENST00000540622ANO2chr12

5936935

-DCP1Bchr12

2077076

-
intron-intronENST00000538154ENST00000541700ANO2chr12

5936935

-DCP1Bchr12

2077076

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000327087ANO2chr125936935-ENST00000280665DCP1Bchr122077076-2639952722486804
ENST00000327087ANO2chr125936935-ENST00000397173DCP1Bchr122077076-2541952722486804
ENST00000546188ANO2chr125936935-ENST00000280665DCP1Bchr122077076-2642955722489805
ENST00000546188ANO2chr125936935-ENST00000397173DCP1Bchr122077076-2544955722489805
ENST00000356134ANO2chr125936935-ENST00000280665DCP1Bchr122077076-2642955722489805
ENST00000356134ANO2chr125936935-ENST00000397173DCP1Bchr122077076-2544955722489805

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327087ENST00000280665ANO2chr125936935-DCP1Bchr122077076-0.0187539890.981246
ENST00000327087ENST00000397173ANO2chr125936935-DCP1Bchr122077076-0.0244418570.97555816
ENST00000546188ENST00000280665ANO2chr125936935-DCP1Bchr122077076-0.0170363880.9829637
ENST00000546188ENST00000397173ANO2chr125936935-DCP1Bchr122077076-0.0230345970.9769654
ENST00000356134ENST00000280665ANO2chr125936935-DCP1Bchr122077076-0.0170363880.9829637
ENST00000356134ENST00000397173ANO2chr125936935-DCP1Bchr122077076-0.0230345970.9769654

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Fusion Genomic Features for ANO2-DCP1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANO2-DCP1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:5936935/chr12:2077076)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDCP1Bchr12:5936935chr12:2077076ENST0000028066529252_261106618.0Compositional biasNote=Poly-Gln

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-7261001_1003293999.0MotifNote=DLG4 binding (PDZ)
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-8271001_10032941000.0MotifNote=DLG4 binding (PDZ)
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-7261_365293999.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726387_434293999.0Topological domainExtracellular
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726456_538293999.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726560_582293999.0Topological domainExtracellular
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726604_623293999.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726645_748293999.0Topological domainExtracellular
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726770_801293999.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726823_907293999.0Topological domainExtracellular
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726929_1003293999.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-8271_3652941000.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827387_4342941000.0Topological domainExtracellular
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827456_5382941000.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827560_5822941000.0Topological domainExtracellular
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827604_6232941000.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827645_7482941000.0Topological domainExtracellular
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827770_8012941000.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827823_9072941000.0Topological domainExtracellular
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827929_10032941000.0Topological domainCytoplasmic
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726366_386293999.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726435_455293999.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726539_559293999.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726583_603293999.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726624_644293999.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726749_769293999.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726802_822293999.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000327087-726908_928293999.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827366_3862941000.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827435_4552941000.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827539_5592941000.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827583_6032941000.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827624_6442941000.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827749_7692941000.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827802_8222941000.0TransmembraneHelical
HgeneANO2chr12:5936935chr12:2077076ENST00000356134-827908_9282941000.0TransmembraneHelical


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Fusion Gene Sequence for ANO2-DCP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4870_4870_1_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000327087_DCP1B_chr12_2077076_ENST00000280665_length(transcript)=2639nt_BP=952nt
CCAGGCTCCTTCTCTATAAAGTGGGATCTATCATGACCAGCCTACCTTATCAATATAGGAGAGAAAATCTTCATGCCTGAAGATATACCC
CTGCTCCCTGGCTCCCCACGCCGGCTGAGCCCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG
CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGCGGTGGAGAGAGCACCCGCAGCAGCTCTGTC
ATCAACAACTATCTGGATGCCAATGAGCCTGTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC
TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGCCACTCGCTGGCTATCGTCTCCAATGGGGAG
ACAGGCAAGGAGCCTCATGCTGGGGGCCCAGGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG
GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAAAGCCAGGGATCCATCTTTGTCCGGATACAC
GCCCCGTGGCAGGTGCTGGCCAGAGAGGCAGAATTCTTGAAGATCAAAGTTCCTACCAAGAAAATGTACGAGATCAAAGCAGGAGGCAGC
ATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAAAAC
CTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGCATT
GTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGTGTCCATCTATGGAATTTGGTTTTATGATAAGGAAGAA
TGCCAAAGAATTGCAGAGCTTATGAAAAACCTAACTCAGTATGAACAGTTGAAAGCCCATCAGGGAACTGGAGCAGGAATTTCCCCAGTG
ATCCTCAATTCAGGAGAGGGCAAAGAAGTAGACATTTTACGAATGCTCATCAAGGCCAAAGACGAATACACAAAGTGTAAAACCTGTTCT
GAGCCAAAAAAGATAACCAGTTCCTCTGCCATCTATGACAATCCAAATCTCATCAAACCAATTCCAGTGAAACCCAGTGAAAACCAGCAA
CAGCGTATACCTCAGCCCAACCAGACCTTAGACCCTGAACCCCAACACTTATCCTTGACAGCTCTGTTTGGGAAGCAGGACAAAGCTACA
TGTCAGGAAACTGTGGAGCCTCCGCAGACTCTCCACCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGAAGCTTCCAATTAGGCAGGGG
GTTGTACGCTCCCTGTCCTATGAGGAACCCAGAAGACACTCACCCCCCATTGAGAAGCAGCTCTGTCCAGCCATTCAGAAACTCATGGTC
AGGAGCGCAGACCTCCACCCATTGTCAGAGCTGCCTGAAAACCGGCCTTGTGAAAATGGCAGTACCCATTCTGCGGGAGAATTTTTTACA
GGACCTGTCCAGCCAGGGTCTCCTCACAACATTGGAACTTCTCGTGGTGTACAAAATGCTTCCAGAACTCAGAACCTGTTCGAGAAACTT
CAGAGTACCCCAGGGGCAGCAAACAAGTGTGACCCTAGTACACCAGCACCTGCCAGCTCAGCTGCCCTGAACCGCAGCAGAGCTCCCACT
TCTGTCACCCCTGTGGCTCCAGGAAAGGGTCTGGCTCAGCCACCACAGGCCTATTTCAATGGCTCCCTTCCACCTCAGACAGTAGGACAT
CAGGCTCATGGAAGAGAACAGTCCACACTCCCAAGACAAACACTCCCCATCTCTGGTAGTCAGACTGGCAGCTCTGGAGTGATCTCCCCT
CAAGAGTTACTGAAGAAGCTTCAGATTGTACAGCAGGAGCAGCAGCTGCATGCCTCTAACCGGCCAGCCTTGGCCGCTAAGTTTCCTGTG
CTCGCTCAGAGCTCTGGAACAGGGAAACCCTTGGAATCCTGGATCAACAAGACACCCAACACAGAACAGCAGACTCCTCTTTTCCAGGTC
ATCTCACCTCAGCGCATCCCTGCTACAGCAGCTCCGTCTCTGCTTATGTCCCCCATGGTGTTCGCACAACCCACCTCCGTCCCGCCAAAG
GAAAGGGAGAGCGGCCTCTTGCCTGTGGGAGGCCAGGAGCCACCTGCTGCTGCCACCAGCCTCCTCCTGCCCATACAGAGCCCGGAGCCC
TCCGTGATCACCAGCAGCCCACTCACCAAGCTCCAGCTCCAGGAGGCACTGCTGTACCTCATTCAGAATGATGACAACTTCTTAAATATA
ATCTATGAAGCCTATCTCTTCAGCATGACTCAAGCAGCCATGAAAAAGACTATGTGACAGCAAGGCCTTTTAAAACTGATTTTCAAGGTC
CTTCTAGAACTCCGGCACAAGGTTCTTTCATGTTGAGTGTTGTTTCCTTCAATGTTTCTGCCTTTTTTAAAAAAAAAGTATGTGTAATAT

>4870_4870_1_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000327087_DCP1B_chr12_2077076_ENST00000280665_length(amino acids)=804AA_BP=3
MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHD
SQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS
IFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDN
ATRSRIVHEILKRTACSRANNTMVSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYT
KCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQEK
LPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQ
NLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTGS
SGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQP

--------------------------------------------------------------
>4870_4870_2_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000327087_DCP1B_chr12_2077076_ENST00000397173_length(transcript)=2541nt_BP=952nt
CCAGGCTCCTTCTCTATAAAGTGGGATCTATCATGACCAGCCTACCTTATCAATATAGGAGAGAAAATCTTCATGCCTGAAGATATACCC
CTGCTCCCTGGCTCCCCACGCCGGCTGAGCCCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG
CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGCGGTGGAGAGAGCACCCGCAGCAGCTCTGTC
ATCAACAACTATCTGGATGCCAATGAGCCTGTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC
TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGCCACTCGCTGGCTATCGTCTCCAATGGGGAG
ACAGGCAAGGAGCCTCATGCTGGGGGCCCAGGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG
GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAAAGCCAGGGATCCATCTTTGTCCGGATACAC
GCCCCGTGGCAGGTGCTGGCCAGAGAGGCAGAATTCTTGAAGATCAAAGTTCCTACCAAGAAAATGTACGAGATCAAAGCAGGAGGCAGC
ATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAAAAC
CTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGCATT
GTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGTGTCCATCTATGGAATTTGGTTTTATGATAAGGAAGAA
TGCCAAAGAATTGCAGAGCTTATGAAAAACCTAACTCAGTATGAACAGTTGAAAGCCCATCAGGGAACTGGAGCAGGAATTTCCCCAGTG
ATCCTCAATTCAGGAGAGGGCAAAGAAGTAGACATTTTACGAATGCTCATCAAGGCCAAAGACGAATACACAAAGTGTAAAACCTGTTCT
GAGCCAAAAAAGATAACCAGTTCCTCTGCCATCTATGACAATCCAAATCTCATCAAACCAATTCCAGTGAAACCCAGTGAAAACCAGCAA
CAGCGTATACCTCAGCCCAACCAGACCTTAGACCCTGAACCCCAACACTTATCCTTGACAGCTCTGTTTGGGAAGCAGGACAAAGCTACA
TGTCAGGAAACTGTGGAGCCTCCGCAGACTCTCCACCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGAAGCTTCCAATTAGGCAGGGG
GTTGTACGCTCCCTGTCCTATGAGGAACCCAGAAGACACTCACCCCCCATTGAGAAGCAGCTCTGTCCAGCCATTCAGAAACTCATGGTC
AGGAGCGCAGACCTCCACCCATTGTCAGAGCTGCCTGAAAACCGGCCTTGTGAAAATGGCAGTACCCATTCTGCGGGAGAATTTTTTACA
GGACCTGTCCAGCCAGGGTCTCCTCACAACATTGGAACTTCTCGTGGTGTACAAAATGCTTCCAGAACTCAGAACCTGTTCGAGAAACTT
CAGAGTACCCCAGGGGCAGCAAACAAGTGTGACCCTAGTACACCAGCACCTGCCAGCTCAGCTGCCCTGAACCGCAGCAGAGCTCCCACT
TCTGTCACCCCTGTGGCTCCAGGAAAGGGTCTGGCTCAGCCACCACAGGCCTATTTCAATGGCTCCCTTCCACCTCAGACAGTAGGACAT
CAGGCTCATGGAAGAGAACAGTCCACACTCCCAAGACAAACACTCCCCATCTCTGGTAGTCAGACTGGCAGCTCTGGAGTGATCTCCCCT
CAAGAGTTACTGAAGAAGCTTCAGATTGTACAGCAGGAGCAGCAGCTGCATGCCTCTAACCGGCCAGCCTTGGCCGCTAAGTTTCCTGTG
CTCGCTCAGAGCTCTGGAACAGGGAAACCCTTGGAATCCTGGATCAACAAGACACCCAACACAGAACAGCAGACTCCTCTTTTCCAGGTC
ATCTCACCTCAGCGCATCCCTGCTACAGCAGCTCCGTCTCTGCTTATGTCCCCCATGGTGTTCGCACAACCCACCTCCGTCCCGCCAAAG
GAAAGGGAGAGCGGCCTCTTGCCTGTGGGAGGCCAGGAGCCACCTGCTGCTGCCACCAGCCTCCTCCTGCCCATACAGAGCCCGGAGCCC
TCCGTGATCACCAGCAGCCCACTCACCAAGCTCCAGCTCCAGGAGGCACTGCTGTACCTCATTCAGAATGATGACAACTTCTTAAATATA
ATCTATGAAGCCTATCTCTTCAGCATGACTCAAGCAGCCATGAAAAAGACTATGTGACAGCAAGGCCTTTTAAAACTGATTTTCAAGGTC

>4870_4870_2_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000327087_DCP1B_chr12_2077076_ENST00000397173_length(amino acids)=804AA_BP=3
MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHD
SQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS
IFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDN
ATRSRIVHEILKRTACSRANNTMVSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYT
KCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQEK
LPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQ
NLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTGS
SGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQP

--------------------------------------------------------------
>4870_4870_3_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000356134_DCP1B_chr12_2077076_ENST00000280665_length(transcript)=2642nt_BP=955nt
CCAGGCTCCTTCTCTATAAAGTGGGATCTATCATGACCAGCCTACCTTATCAATATAGGAGAGAAAATCTTCATGCCTGAAGATATACCC
CTGCTCCCTGGCTCCCCACGCCGGCTGAGCCCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG
CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGCGGTGGAGAGAGCACCCGCAGCAGCTCTGTC
ATCAACAACTATCTGGATGCCAATGAGCCTGTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC
TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGCCACTCGCTGGCTATCGTCTCCAATGGGGAG
ACAGGCAAGGAGCCTCATGCTGGGGGCCCAGGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG
GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAAAGCCAGGGATCCATCTTTGTCCGGATACAC
GCCCCGTGGCAGGTGCTGGCCAGAGAGGCAGAATTCTTGAAGATCAAAGTTCCTACCAAGAAAGAGATGTACGAGATCAAAGCAGGAGGC
AGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAA
AACCTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGC
ATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGTGTCCATCTATGGAATTTGGTTTTATGATAAGGAA
GAATGCCAAAGAATTGCAGAGCTTATGAAAAACCTAACTCAGTATGAACAGTTGAAAGCCCATCAGGGAACTGGAGCAGGAATTTCCCCA
GTGATCCTCAATTCAGGAGAGGGCAAAGAAGTAGACATTTTACGAATGCTCATCAAGGCCAAAGACGAATACACAAAGTGTAAAACCTGT
TCTGAGCCAAAAAAGATAACCAGTTCCTCTGCCATCTATGACAATCCAAATCTCATCAAACCAATTCCAGTGAAACCCAGTGAAAACCAG
CAACAGCGTATACCTCAGCCCAACCAGACCTTAGACCCTGAACCCCAACACTTATCCTTGACAGCTCTGTTTGGGAAGCAGGACAAAGCT
ACATGTCAGGAAACTGTGGAGCCTCCGCAGACTCTCCACCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGAAGCTTCCAATTAGGCAG
GGGGTTGTACGCTCCCTGTCCTATGAGGAACCCAGAAGACACTCACCCCCCATTGAGAAGCAGCTCTGTCCAGCCATTCAGAAACTCATG
GTCAGGAGCGCAGACCTCCACCCATTGTCAGAGCTGCCTGAAAACCGGCCTTGTGAAAATGGCAGTACCCATTCTGCGGGAGAATTTTTT
ACAGGACCTGTCCAGCCAGGGTCTCCTCACAACATTGGAACTTCTCGTGGTGTACAAAATGCTTCCAGAACTCAGAACCTGTTCGAGAAA
CTTCAGAGTACCCCAGGGGCAGCAAACAAGTGTGACCCTAGTACACCAGCACCTGCCAGCTCAGCTGCCCTGAACCGCAGCAGAGCTCCC
ACTTCTGTCACCCCTGTGGCTCCAGGAAAGGGTCTGGCTCAGCCACCACAGGCCTATTTCAATGGCTCCCTTCCACCTCAGACAGTAGGA
CATCAGGCTCATGGAAGAGAACAGTCCACACTCCCAAGACAAACACTCCCCATCTCTGGTAGTCAGACTGGCAGCTCTGGAGTGATCTCC
CCTCAAGAGTTACTGAAGAAGCTTCAGATTGTACAGCAGGAGCAGCAGCTGCATGCCTCTAACCGGCCAGCCTTGGCCGCTAAGTTTCCT
GTGCTCGCTCAGAGCTCTGGAACAGGGAAACCCTTGGAATCCTGGATCAACAAGACACCCAACACAGAACAGCAGACTCCTCTTTTCCAG
GTCATCTCACCTCAGCGCATCCCTGCTACAGCAGCTCCGTCTCTGCTTATGTCCCCCATGGTGTTCGCACAACCCACCTCCGTCCCGCCA
AAGGAAAGGGAGAGCGGCCTCTTGCCTGTGGGAGGCCAGGAGCCACCTGCTGCTGCCACCAGCCTCCTCCTGCCCATACAGAGCCCGGAG
CCCTCCGTGATCACCAGCAGCCCACTCACCAAGCTCCAGCTCCAGGAGGCACTGCTGTACCTCATTCAGAATGATGACAACTTCTTAAAT
ATAATCTATGAAGCCTATCTCTTCAGCATGACTCAAGCAGCCATGAAAAAGACTATGTGACAGCAAGGCCTTTTAAAACTGATTTTCAAG
GTCCTTCTAGAACTCCGGCACAAGGTTCTTTCATGTTGAGTGTTGTTTCCTTCAATGTTTCTGCCTTTTTTAAAAAAAAAGTATGTGTAA

>4870_4870_3_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000356134_DCP1B_chr12_2077076_ENST00000280665_length(amino acids)=805AA_BP=3
MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHD
SQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS
IFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFD
NATRSRIVHEILKRTACSRANNTMVSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEY
TKCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQE
KLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRT
QNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTG
SSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQ

--------------------------------------------------------------
>4870_4870_4_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000356134_DCP1B_chr12_2077076_ENST00000397173_length(transcript)=2544nt_BP=955nt
CCAGGCTCCTTCTCTATAAAGTGGGATCTATCATGACCAGCCTACCTTATCAATATAGGAGAGAAAATCTTCATGCCTGAAGATATACCC
CTGCTCCCTGGCTCCCCACGCCGGCTGAGCCCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG
CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGCGGTGGAGAGAGCACCCGCAGCAGCTCTGTC
ATCAACAACTATCTGGATGCCAATGAGCCTGTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC
TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGCCACTCGCTGGCTATCGTCTCCAATGGGGAG
ACAGGCAAGGAGCCTCATGCTGGGGGCCCAGGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG
GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAAAGCCAGGGATCCATCTTTGTCCGGATACAC
GCCCCGTGGCAGGTGCTGGCCAGAGAGGCAGAATTCTTGAAGATCAAAGTTCCTACCAAGAAAGAGATGTACGAGATCAAAGCAGGAGGC
AGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAA
AACCTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGC
ATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGTGTCCATCTATGGAATTTGGTTTTATGATAAGGAA
GAATGCCAAAGAATTGCAGAGCTTATGAAAAACCTAACTCAGTATGAACAGTTGAAAGCCCATCAGGGAACTGGAGCAGGAATTTCCCCA
GTGATCCTCAATTCAGGAGAGGGCAAAGAAGTAGACATTTTACGAATGCTCATCAAGGCCAAAGACGAATACACAAAGTGTAAAACCTGT
TCTGAGCCAAAAAAGATAACCAGTTCCTCTGCCATCTATGACAATCCAAATCTCATCAAACCAATTCCAGTGAAACCCAGTGAAAACCAG
CAACAGCGTATACCTCAGCCCAACCAGACCTTAGACCCTGAACCCCAACACTTATCCTTGACAGCTCTGTTTGGGAAGCAGGACAAAGCT
ACATGTCAGGAAACTGTGGAGCCTCCGCAGACTCTCCACCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGAAGCTTCCAATTAGGCAG
GGGGTTGTACGCTCCCTGTCCTATGAGGAACCCAGAAGACACTCACCCCCCATTGAGAAGCAGCTCTGTCCAGCCATTCAGAAACTCATG
GTCAGGAGCGCAGACCTCCACCCATTGTCAGAGCTGCCTGAAAACCGGCCTTGTGAAAATGGCAGTACCCATTCTGCGGGAGAATTTTTT
ACAGGACCTGTCCAGCCAGGGTCTCCTCACAACATTGGAACTTCTCGTGGTGTACAAAATGCTTCCAGAACTCAGAACCTGTTCGAGAAA
CTTCAGAGTACCCCAGGGGCAGCAAACAAGTGTGACCCTAGTACACCAGCACCTGCCAGCTCAGCTGCCCTGAACCGCAGCAGAGCTCCC
ACTTCTGTCACCCCTGTGGCTCCAGGAAAGGGTCTGGCTCAGCCACCACAGGCCTATTTCAATGGCTCCCTTCCACCTCAGACAGTAGGA
CATCAGGCTCATGGAAGAGAACAGTCCACACTCCCAAGACAAACACTCCCCATCTCTGGTAGTCAGACTGGCAGCTCTGGAGTGATCTCC
CCTCAAGAGTTACTGAAGAAGCTTCAGATTGTACAGCAGGAGCAGCAGCTGCATGCCTCTAACCGGCCAGCCTTGGCCGCTAAGTTTCCT
GTGCTCGCTCAGAGCTCTGGAACAGGGAAACCCTTGGAATCCTGGATCAACAAGACACCCAACACAGAACAGCAGACTCCTCTTTTCCAG
GTCATCTCACCTCAGCGCATCCCTGCTACAGCAGCTCCGTCTCTGCTTATGTCCCCCATGGTGTTCGCACAACCCACCTCCGTCCCGCCA
AAGGAAAGGGAGAGCGGCCTCTTGCCTGTGGGAGGCCAGGAGCCACCTGCTGCTGCCACCAGCCTCCTCCTGCCCATACAGAGCCCGGAG
CCCTCCGTGATCACCAGCAGCCCACTCACCAAGCTCCAGCTCCAGGAGGCACTGCTGTACCTCATTCAGAATGATGACAACTTCTTAAAT
ATAATCTATGAAGCCTATCTCTTCAGCATGACTCAAGCAGCCATGAAAAAGACTATGTGACAGCAAGGCCTTTTAAAACTGATTTTCAAG

>4870_4870_4_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000356134_DCP1B_chr12_2077076_ENST00000397173_length(amino acids)=805AA_BP=3
MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHD
SQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS
IFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFD
NATRSRIVHEILKRTACSRANNTMVSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEY
TKCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQE
KLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRT
QNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTG
SSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQ

--------------------------------------------------------------
>4870_4870_5_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000546188_DCP1B_chr12_2077076_ENST00000280665_length(transcript)=2642nt_BP=955nt
CCAGGCTCCTTCTCTATAAAGTGGGATCTATCATGACCAGCCTACCTTATCAATATAGGAGAGAAAATCTTCATGCCTGAAGATATACCC
CTGCTCCCTGGCTCCCCACGCCGGCTGAGCCCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG
CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGCGGTGGAGAGAGCACCCGCAGCAGCTCTGTC
ATCAACAACTATCTGGATGCCAATGAGCCTGTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC
TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGCCACTCGCTGGCTATCGTCTCCAATGGGGAG
ACAGGCAAGGAGCCTCATGCTGGGGGCCCAGGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG
GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAAAGCCAGGGATCCATCTTTGTCCGGATACAC
GCCCCGTGGCAGGTGCTGGCCAGAGAGGCAGAATTCTTGAAGATCAAAGTTCCTACCAAGAAAGAGATGTACGAGATCAAAGCAGGAGGC
AGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAA
AACCTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGC
ATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGTGTCCATCTATGGAATTTGGTTTTATGATAAGGAA
GAATGCCAAAGAATTGCAGAGCTTATGAAAAACCTAACTCAGTATGAACAGTTGAAAGCCCATCAGGGAACTGGAGCAGGAATTTCCCCA
GTGATCCTCAATTCAGGAGAGGGCAAAGAAGTAGACATTTTACGAATGCTCATCAAGGCCAAAGACGAATACACAAAGTGTAAAACCTGT
TCTGAGCCAAAAAAGATAACCAGTTCCTCTGCCATCTATGACAATCCAAATCTCATCAAACCAATTCCAGTGAAACCCAGTGAAAACCAG
CAACAGCGTATACCTCAGCCCAACCAGACCTTAGACCCTGAACCCCAACACTTATCCTTGACAGCTCTGTTTGGGAAGCAGGACAAAGCT
ACATGTCAGGAAACTGTGGAGCCTCCGCAGACTCTCCACCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGAAGCTTCCAATTAGGCAG
GGGGTTGTACGCTCCCTGTCCTATGAGGAACCCAGAAGACACTCACCCCCCATTGAGAAGCAGCTCTGTCCAGCCATTCAGAAACTCATG
GTCAGGAGCGCAGACCTCCACCCATTGTCAGAGCTGCCTGAAAACCGGCCTTGTGAAAATGGCAGTACCCATTCTGCGGGAGAATTTTTT
ACAGGACCTGTCCAGCCAGGGTCTCCTCACAACATTGGAACTTCTCGTGGTGTACAAAATGCTTCCAGAACTCAGAACCTGTTCGAGAAA
CTTCAGAGTACCCCAGGGGCAGCAAACAAGTGTGACCCTAGTACACCAGCACCTGCCAGCTCAGCTGCCCTGAACCGCAGCAGAGCTCCC
ACTTCTGTCACCCCTGTGGCTCCAGGAAAGGGTCTGGCTCAGCCACCACAGGCCTATTTCAATGGCTCCCTTCCACCTCAGACAGTAGGA
CATCAGGCTCATGGAAGAGAACAGTCCACACTCCCAAGACAAACACTCCCCATCTCTGGTAGTCAGACTGGCAGCTCTGGAGTGATCTCC
CCTCAAGAGTTACTGAAGAAGCTTCAGATTGTACAGCAGGAGCAGCAGCTGCATGCCTCTAACCGGCCAGCCTTGGCCGCTAAGTTTCCT
GTGCTCGCTCAGAGCTCTGGAACAGGGAAACCCTTGGAATCCTGGATCAACAAGACACCCAACACAGAACAGCAGACTCCTCTTTTCCAG
GTCATCTCACCTCAGCGCATCCCTGCTACAGCAGCTCCGTCTCTGCTTATGTCCCCCATGGTGTTCGCACAACCCACCTCCGTCCCGCCA
AAGGAAAGGGAGAGCGGCCTCTTGCCTGTGGGAGGCCAGGAGCCACCTGCTGCTGCCACCAGCCTCCTCCTGCCCATACAGAGCCCGGAG
CCCTCCGTGATCACCAGCAGCCCACTCACCAAGCTCCAGCTCCAGGAGGCACTGCTGTACCTCATTCAGAATGATGACAACTTCTTAAAT
ATAATCTATGAAGCCTATCTCTTCAGCATGACTCAAGCAGCCATGAAAAAGACTATGTGACAGCAAGGCCTTTTAAAACTGATTTTCAAG
GTCCTTCTAGAACTCCGGCACAAGGTTCTTTCATGTTGAGTGTTGTTTCCTTCAATGTTTCTGCCTTTTTTAAAAAAAAAGTATGTGTAA

>4870_4870_5_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000546188_DCP1B_chr12_2077076_ENST00000280665_length(amino acids)=805AA_BP=3
MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHD
SQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS
IFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFD
NATRSRIVHEILKRTACSRANNTMVSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEY
TKCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQE
KLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRT
QNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTG
SSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQ

--------------------------------------------------------------
>4870_4870_6_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000546188_DCP1B_chr12_2077076_ENST00000397173_length(transcript)=2544nt_BP=955nt
CCAGGCTCCTTCTCTATAAAGTGGGATCTATCATGACCAGCCTACCTTATCAATATAGGAGAGAAAATCTTCATGCCTGAAGATATACCC
CTGCTCCCTGGCTCCCCACGCCGGCTGAGCCCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG
CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGCGGTGGAGAGAGCACCCGCAGCAGCTCTGTC
ATCAACAACTATCTGGATGCCAATGAGCCTGTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC
TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGCCACTCGCTGGCTATCGTCTCCAATGGGGAG
ACAGGCAAGGAGCCTCATGCTGGGGGCCCAGGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG
GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAAAGCCAGGGATCCATCTTTGTCCGGATACAC
GCCCCGTGGCAGGTGCTGGCCAGAGAGGCAGAATTCTTGAAGATCAAAGTTCCTACCAAGAAAGAGATGTACGAGATCAAAGCAGGAGGC
AGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGAGTTCCAGAACACAGCAACAACAAGATGAAA
AACCTCTCCTACCCATTCTCCAGGGAGAAGATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGCAGCCGC
ATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGTGTCCATCTATGGAATTTGGTTTTATGATAAGGAA
GAATGCCAAAGAATTGCAGAGCTTATGAAAAACCTAACTCAGTATGAACAGTTGAAAGCCCATCAGGGAACTGGAGCAGGAATTTCCCCA
GTGATCCTCAATTCAGGAGAGGGCAAAGAAGTAGACATTTTACGAATGCTCATCAAGGCCAAAGACGAATACACAAAGTGTAAAACCTGT
TCTGAGCCAAAAAAGATAACCAGTTCCTCTGCCATCTATGACAATCCAAATCTCATCAAACCAATTCCAGTGAAACCCAGTGAAAACCAG
CAACAGCGTATACCTCAGCCCAACCAGACCTTAGACCCTGAACCCCAACACTTATCCTTGACAGCTCTGTTTGGGAAGCAGGACAAAGCT
ACATGTCAGGAAACTGTGGAGCCTCCGCAGACTCTCCACCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGAAGCTTCCAATTAGGCAG
GGGGTTGTACGCTCCCTGTCCTATGAGGAACCCAGAAGACACTCACCCCCCATTGAGAAGCAGCTCTGTCCAGCCATTCAGAAACTCATG
GTCAGGAGCGCAGACCTCCACCCATTGTCAGAGCTGCCTGAAAACCGGCCTTGTGAAAATGGCAGTACCCATTCTGCGGGAGAATTTTTT
ACAGGACCTGTCCAGCCAGGGTCTCCTCACAACATTGGAACTTCTCGTGGTGTACAAAATGCTTCCAGAACTCAGAACCTGTTCGAGAAA
CTTCAGAGTACCCCAGGGGCAGCAAACAAGTGTGACCCTAGTACACCAGCACCTGCCAGCTCAGCTGCCCTGAACCGCAGCAGAGCTCCC
ACTTCTGTCACCCCTGTGGCTCCAGGAAAGGGTCTGGCTCAGCCACCACAGGCCTATTTCAATGGCTCCCTTCCACCTCAGACAGTAGGA
CATCAGGCTCATGGAAGAGAACAGTCCACACTCCCAAGACAAACACTCCCCATCTCTGGTAGTCAGACTGGCAGCTCTGGAGTGATCTCC
CCTCAAGAGTTACTGAAGAAGCTTCAGATTGTACAGCAGGAGCAGCAGCTGCATGCCTCTAACCGGCCAGCCTTGGCCGCTAAGTTTCCT
GTGCTCGCTCAGAGCTCTGGAACAGGGAAACCCTTGGAATCCTGGATCAACAAGACACCCAACACAGAACAGCAGACTCCTCTTTTCCAG
GTCATCTCACCTCAGCGCATCCCTGCTACAGCAGCTCCGTCTCTGCTTATGTCCCCCATGGTGTTCGCACAACCCACCTCCGTCCCGCCA
AAGGAAAGGGAGAGCGGCCTCTTGCCTGTGGGAGGCCAGGAGCCACCTGCTGCTGCCACCAGCCTCCTCCTGCCCATACAGAGCCCGGAG
CCCTCCGTGATCACCAGCAGCCCACTCACCAAGCTCCAGCTCCAGGAGGCACTGCTGTACCTCATTCAGAATGATGACAACTTCTTAAAT
ATAATCTATGAAGCCTATCTCTTCAGCATGACTCAAGCAGCCATGAAAAAGACTATGTGACAGCAAGGCCTTTTAAAACTGATTTTCAAG

>4870_4870_6_ANO2-DCP1B_ANO2_chr12_5936935_ENST00000546188_DCP1B_chr12_2077076_ENST00000397173_length(amino acids)=805AA_BP=3
MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHD
SQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS
IFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFD
NATRSRIVHEILKRTACSRANNTMVSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEY
TKCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQE
KLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRT
QNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTG
SSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANO2-DCP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANO2-DCP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANO2-DCP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource