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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TIGAR-ZNF827 (FusionGDB2 ID:HG57103TG152485)

Fusion Gene Summary for TIGAR-ZNF827

check button Fusion gene summary
Fusion gene informationFusion gene name: TIGAR-ZNF827
Fusion gene ID: hg57103tg152485
HgeneTgene
Gene symbol

TIGAR

ZNF827

Gene ID

57103

152485

Gene nameTP53 induced glycolysis regulatory phosphatasezinc finger protein 827
SynonymsC12orf5|FR2BP-
Cytomap('C12orf5','TIGAR')('ZNF827','ZNF827')

12p13.32

4q31.21-q31.22

Type of geneprotein-codingprotein-coding
Descriptionfructose-2,6-bisphosphatase TIGARTP53-induced glycolysis and apoptosis regulatorfructose-2,6-bisphosphate 2-phosphataseprobable fructose-2,6-bisphosphatase TIGARtransactivated by NS3TP2 proteinzinc finger protein 827
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000179259, ENST00000537251, 
Fusion gene scores* DoF score5 X 3 X 3=4511 X 4 X 7=308
# samples 711
** MAII scorelog2(7/45*10)=0.637429920615292
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/308*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TIGAR [Title/Abstract] AND ZNF827 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC12orf5(4430469)-ZNF827(146744677), # samples:1
TIGAR(4430469)-ZNF827(146744677), # samples:1
Anticipated loss of major functional domain due to fusion event.C12orf5-ZNF827 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf5-ZNF827 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf5-ZNF827 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf5-ZNF827 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIGAR

GO:0006003

fructose 2,6-bisphosphate metabolic process

19015259

HgeneTIGAR

GO:0006974

cellular response to DNA damage stimulus

25928429

HgeneTIGAR

GO:0030388

fructose 1,6-bisphosphate metabolic process

19015259

HgeneTIGAR

GO:0043069

negative regulation of programmed cell death

23185017

HgeneTIGAR

GO:0071279

cellular response to cobalt ion

25928429

HgeneTIGAR

GO:0071456

cellular response to hypoxia

23185017

HgeneTIGAR

GO:1903301

positive regulation of hexokinase activity

23185017


check buttonFusion gene breakpoints across C12orf5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZNF827 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HL-01AC12orf5chr12

4430469

-ZNF827chr4

146744677

-
ChimerDB4SARCTCGA-3B-A9HL-01ATIGARchr12

4430469

+ZNF827chr4

146744677

-


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Fusion Gene ORF analysis for TIGAR-ZNF827

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000179259ENST00000511534C12orf5chr12

4430469

-ZNF827chr4

146744677

-
In-frameENST00000179259ENST00000379448C12orf5chr12

4430469

-ZNF827chr4

146744677

-
In-frameENST00000179259ENST00000508784C12orf5chr12

4430469

-ZNF827chr4

146744677

-
In-frameENST00000179259ENST00000513320C12orf5chr12

4430469

-ZNF827chr4

146744677

-
intron-3CDSENST00000537251ENST00000379448C12orf5chr12

4430469

-ZNF827chr4

146744677

-
intron-3CDSENST00000537251ENST00000508784C12orf5chr12

4430469

-ZNF827chr4

146744677

-
intron-3CDSENST00000537251ENST00000513320C12orf5chr12

4430469

-ZNF827chr4

146744677

-
intron-intronENST00000537251ENST00000511534C12orf5chr12

4430469

-ZNF827chr4

146744677

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000179259C12orf5chr124430469-ENST00000508784ZNF827chr4146744677-505599671065332
ENST00000179259C12orf5chr124430469-ENST00000513320ZNF827chr4146744677-195399671065332
ENST00000179259C12orf5chr124430469-ENST00000379448ZNF827chr4146744677-195399671053328

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000179259ENST00000508784C12orf5chr124430469-ZNF827chr4146744677-0.0001400730.9998599
ENST00000179259ENST00000513320C12orf5chr124430469-ZNF827chr4146744677-0.006073480.9939266
ENST00000179259ENST00000379448C12orf5chr124430469-ZNF827chr4146744677-0.0054843180.9945157

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Fusion Genomic Features for TIGAR-ZNF827


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for TIGAR-ZNF827


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4430469/:146744677)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF827chr12:4430469chr4:146744677ENST00000379448615961_972759995.0Compositional biasNote=Poly-Ser
TgeneZNF827chr12:4430469chr4:146744677ENST00000508784615961_9727591976.6666666666667Compositional biasNote=Poly-Ser
TgeneZNF827chr12:4430469chr4:146744677ENST000003794486151019_1041759995.0Zinc fingerC2H2-type 8
TgeneZNF827chr12:4430469chr4:146744677ENST000003794486151047_1069759995.0Zinc fingerC2H2-type 9
TgeneZNF827chr12:4430469chr4:146744677ENST00000379448615817_839759995.0Zinc fingerC2H2-type 4
TgeneZNF827chr12:4430469chr4:146744677ENST00000379448615845_867759995.0Zinc fingerC2H2-type 5
TgeneZNF827chr12:4430469chr4:146744677ENST00000379448615897_919759995.0Zinc fingerC2H2-type 6
TgeneZNF827chr12:4430469chr4:146744677ENST00000379448615929_952759995.0Zinc fingerC2H2-type 7
TgeneZNF827chr12:4430469chr4:146744677ENST000005087846151019_10417591976.6666666666667Zinc fingerC2H2-type 8
TgeneZNF827chr12:4430469chr4:146744677ENST000005087846151047_10697591976.6666666666667Zinc fingerC2H2-type 9
TgeneZNF827chr12:4430469chr4:146744677ENST00000508784615817_8397591976.6666666666667Zinc fingerC2H2-type 4
TgeneZNF827chr12:4430469chr4:146744677ENST00000508784615845_8677591976.6666666666667Zinc fingerC2H2-type 5
TgeneZNF827chr12:4430469chr4:146744677ENST00000508784615897_9197591976.6666666666667Zinc fingerC2H2-type 6
TgeneZNF827chr12:4430469chr4:146744677ENST00000508784615929_9527591976.6666666666667Zinc fingerC2H2-type 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF827chr12:4430469chr4:146744677ENST00000379448615311_354759995.0Compositional biasNote=Pro-rich
TgeneZNF827chr12:4430469chr4:146744677ENST00000508784615311_3547591976.6666666666667Compositional biasNote=Pro-rich
TgeneZNF827chr12:4430469chr4:146744677ENST00000379448615374_396759995.0Zinc fingerC2H2-type 1
TgeneZNF827chr12:4430469chr4:146744677ENST00000379448615402_424759995.0Zinc fingerC2H2-type 2
TgeneZNF827chr12:4430469chr4:146744677ENST00000379448615433_455759995.0Zinc fingerC2H2-type 3
TgeneZNF827chr12:4430469chr4:146744677ENST00000508784615374_3967591976.6666666666667Zinc fingerC2H2-type 1
TgeneZNF827chr12:4430469chr4:146744677ENST00000508784615402_4247591976.6666666666667Zinc fingerC2H2-type 2
TgeneZNF827chr12:4430469chr4:146744677ENST00000508784615433_4557591976.6666666666667Zinc fingerC2H2-type 3


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Fusion Gene Sequence for TIGAR-ZNF827


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10873_10873_1_C12orf5-ZNF827_C12orf5_chr12_4430469_ENST00000179259_ZNF827_chr4_146744677_ENST00000379448_length(transcript)=1953nt_BP=99nt
GGGGAGGTAGCCCGCAGTGCAGGGGCAGCGCGGCGCGGGGCCACCGACGGGACGCGGCTCCGGGAACATGGCTCGCTTCGCTCTGACTGT
TGTCCGGCACCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAACTGCTGCCCAGTGACTCCGTGCT
GCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCCTGGAAATTCAATGACCAGCTTTT
TCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCACACAGAGGAAAGAAAATACAAATG
CCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTGAAGCTGGTGAGTACAGACACCGA
GGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGTCACGTGTGTGGATTTGAGACCGA
GCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATCTGCTGCACTGCCTGCGACTTCGT
CACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACCCCCAGCGAATCAAATAGCCCCTC
TTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAAAACAAGGGCGGGAACAATCTGCT
GGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTCGAATGTGTTTTTTGCAACTTTGT
CTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGTGATGTGTGCCACAAGTTCATGAA
GACCCCCGAACAGCTGCTGGAGCATAAGAAATGCCACACTGTCCCCACCGGTGGGCTCAAGTAAGGAAACTCAGGACAGTGGTGAGTTTC
AGACTCCTCTAGGTGCCCATTCTGCATTTATTCCACCAACCGCCCCGCTGCCATGGAGTGCCACCTCAAGACCCACTACAAGATGGAGTA
CAAGTGCCGGATCTGCCAGACGGTGAAGGCCAACCAGCTGGAGCTGGAGACGCACACCCGGGAGCACCGCCTGGGCAACCACTACAAGTG
CGACCAGTGCGGCTACCTGTCCAAGACCGCCAACAAGCTCATCGAGCACGTGCGCGTCCACACCGGGGAGCGGCCCTTCCACTGTGACCA
GTGCAGCTACAGCTGCAAGCGCAAGGACAATCTCAACCTGCACAAGAAGCTGAAGCACGCCCCACGCCAGACCTTCAGCTGCGAAGAGTG
CCTGTTCAAGACCACACACCCTTTCGTCTTCAGCCGCCACGTCAAGAAGCACCAGAGTGGGGACTGCCCCGAGGAGGACAAGAAGGGCCT
GTGTCCAGCCCCCAAGGAACCGGCCGGCCCGGGGGCCCCGCTCCTGGTGGTCGGGAGCTCCCGGAATCTCCTGTCTCCCCTGTCAGTTAT
GTCTGCCTCCCAGGCTCTGCAGACCGTGGCCCTGTCGGCAGCCCACGGCAGCAGCTCAGAGCCCAACCTGGCACTCAAGGCTTTGGCCTT
CAACGGCTCCCCTTTGCGCTTTGACAAGTACCGGAACTCAGATTTTGCCCATCTCATTCCCTTGACAATGTTATACCCCAAGAACCACTT
GGATCTCACATTCCACCCTCCCCGACCTCAGACTGCGCCTCCCAGCATCCCCTCACCCAAACACTCCTTCCTGGCCTATCTCGGACTGAG

>10873_10873_1_C12orf5-ZNF827_C12orf5_chr12_4430469_ENST00000179259_ZNF827_chr4_146744677_ENST00000379448_length(amino acids)=328AA_BP=11
MARFALTVVRHPFFSEDTFRQSPFTSNSKELLPSDSVLHGRISAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLH
TEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSI
CCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLSALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGF

--------------------------------------------------------------
>10873_10873_2_C12orf5-ZNF827_C12orf5_chr12_4430469_ENST00000179259_ZNF827_chr4_146744677_ENST00000508784_length(transcript)=5055nt_BP=99nt
GGGGAGGTAGCCCGCAGTGCAGGGGCAGCGCGGCGCGGGGCCACCGACGGGACGCGGCTCCGGGAACATGGCTCGCTTCGCTCTGACTGT
TGTCCGGCACCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAACTGCTGCCCAGTGACTCCGTGCT
GCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCCTGGAAATTCAATGACCAGCTTTT
TCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCACACAGAGGAAAGAAAATACAAATG
CCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTGAAGCTGGTGAGTACAGACACCGA
GGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGTCACGTGTGTGGATTTGAGACCGA
GCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATCTGCTGCACTGCCTGCGACTTCGT
CACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACCCCCAGCGAATCAAATAGCCCCTC
TTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAAAACAAGGGCGGGAACAATCTGCT
GGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTCGAATGTGTTTTTTGCAACTTTGT
CTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGTGATGTGTGCCACAAGTTCATGAA
GACCCCCGAACAGCTGCTGGAGCATAAGAAATGCCACACTGTCCCCACCGGTGGGCTCAACTCAGGACAGTGGTGAGTTTCAGACTCCTC
TAGGTGCCCATTCTGCATTTATTCCACCAACCGCCCCGCTGCCATGGAGTGCCACCTCAAGACCCACTACAAGATGGAGTACAAGTGCCG
GATCTGCCAGACGGTGAAGGCCAACCAGCTGGAGCTGGAGACGCACACCCGGGAGCACCGCCTGGGCAACCACTACAAGTGCGACCAGTG
CGGCTACCTGTCCAAGACCGCCAACAAGCTCATCGAGCACGTGCGCGTCCACACCGGGGAGCGGCCCTTCCACTGTGACCAGTGCAGCTA
CAGCTGCAAGCGCAAGGACAATCTCAACCTGCACAAGAAGCTGAAGCACGCCCCACGCCAGACCTTCAGCTGCGAAGAGTGCCTGTTCAA
GACCACACACCCTTTCGTCTTCAGCCGCCACGTCAAGAAGCACCAGAGTGGGGACTGCCCCGAGGAGGACAAGAAGGGCCTGTGTCCAGC
CCCCAAGGAACCGGCCGGCCCGGGGGCCCCGCTCCTGGTGGTCGGGAGCTCCCGGAATCTCCTGTCTCCCCTGTCAGTTATGTCTGCCTC
CCAGGCTCTGCAGACCGTGGCCCTGTCGGCAGCCCACGGCAGCAGCTCAGAGCCCAACCTGGCACTCAAGGCTTTGGCCTTCAACGGCTC
CCCTTTGCGCTTTGACAAGTACCGGAACTCAGATTTTGCCCATCTCATTCCCTTGACAATGTTATACCCCAAGAACCACTTGGATCTCAC
ATTCCACCCTCCCCGACCTCAGACTGCGCCTCCCAGCATCCCCTCACCCAAACACTCCTTCCTGGCCTATCTCGGACTGAGAGAAAGAGC
AGAGACTGTCTGAGGGCAGCCATGTTCTGTACCAAAAACAGAGAGACAAAAGACAAAAAAAAAAAAAAAAACCACAAAACTTAAACACAA
CCCCAGCAGGTGTATGTTGCTGCAAAACCTACAGACCCCGATGGGTCTGGAACATGTGTACTGTATATCTTTAGTAAGGAATAGAAAATT
GGCTCTGTGTGTATACCTATTGCATTGACCTGAAAGCTGCTTTATCCAATCTTCAGAGAGGTGACCTACTGCATACTTCTACCTTCAGAG
GCATGCCTCCCCAGCCACCCACTCCCACTCTCAGCCCTTCTCCGTACTTTTCTCTGAAAGGAATCTTGTCTTGTTAAACCCTAAAGAGAG
TGTCCTTAATAGCAATCAGCACTTGTAAGCTTATATACTGGTGCATTTGGTTTTCTGTTGGGTGAATGCGGTGTGTGGGCGTTTGTGGAT
TCTGAAAGAGAAAGCCGTGTGTCGTGTGCCATGACATTTCTATTGCACATTCTTTGTACTGGCTTCTTTAACAGCGATGAACGTTCTTTT
CCCTCCTGGGTTGTTCATCCACGACAGTCTCTCCCTGTGCTCCTTCATCACCTTTCCCTCTCTCTTTGATGGCTACAGAGTGGTAGGGCC
TGGTGCTTAGTCGATGAAGGAATGGTAGCCATCTACAGTGCTGCTGGAGATTTCCGCCAGAGCGCTGGAGACCTTGCGCTCAGATCTTCT
CTGGTGATGAAGAGGCGAGGAATCAAGTGACTGATCTGGAAGAAATATCTCGCAGCACTGCAGCTAACATCACAGAACTTAAGTGTGTTT
TGTGTGTGTGCCCACACGTAGACAAATGTGTACGGTGCACACACACAGTGCATCATTTTTTAAGGGCAGATTATATATATATATGAGATG
TATTAATTCAGTGGTTACCATTTGTTTGCAGGAAAAAGAAATGTATGGGTGAAAAAATTTATGGTTGATAAATCCAGCCAAGGAGATTAA
AAGGGGTTTGGATAAATTCTGGGTATAAATGCTCAGACTAAAAAAAAGAAATGGCAGTTTTGCACAGTGCTATGGTCTTGCACTAGTTTT
TGTTTCTCATCTGAAAAAAAAAAAGTAAAATAAAAGGAAGAAAATGTACCTTTTTTATGGAATGAGTAGACTGTATGTTTGAAGATTTAG
CCACAACCTCTTTGACATATAATGACGCAACAAAAAGGTGCTGTTTAGTCCTATGGTTCAGTTTATGCCCCTGACAAGTTTCCATTGTGT
TTTGCCGATCTTCTGGCTAATCGTGGTATCCTCCATGTTATTAGTAATTCTGTATTCCATTTTGTTAACGCCTGGTAGATGTAACCTGCT
AGGAGGCTAACTTTATACTTATTTAAAAGCTCTTATTTTGTGGTCATTAAAATGGCAATTTATGTGCAGCACTTTATTGCAGCAGGAAGC
AGGTGTGGGTTGGTTGTAAAGCTCTTTGCTAATCTTAAAAAGTAATGGGTGATTTAAAAAGAAAAAAGGAAAAAAATCTTTGGCTGAATA
TGTTCATTGCTTGTATTTTTAAAACAACAGAATTTCCAGTATGAAACAGGCTGAAAGAGCAGGAAGAAATGTTCTTTGTATAATAATGGG
AAGTTTGGAATATAAAAGTTTATATATTATTTATCTATTGGAGAACTGGTGTACAGGAGGAACATTTTCTTACTGTGTTGCTGTTTTCCA
TCATGTGTTATCCTAAGAGTTGGGGTTTTTTAAAATCTGTTTCACCAGGGGAAAATAAAAGCATCCCTAATGTTCTTCCTCTAGTCAGTT
TGCTTTGCTGAAAGCTCCCTGGAAATTAGTACAGTTCTACAGGAAGCCAGAAGACTGTACTGTCTGTCCACACCATGGTCTCCTCAGTCC
CCTCCACGCCAGCCCCTCTTCCCCACACCTAGTAGGTGTGCTACACCTCCCTTTGCCAGTCATCCCGCCATGGATGGGGAGCCTACTTGG
TGCCCTGGCAAACCTGTTTACACTAAGGAGATGCCCACAGGGAGCGGGAAGCTCCCAAACCCTCAGTCATTCTCCAGCAGAGACCTTTGC
TCTTGGCCAGGTTTGAAACGATGTTCAACCTCGCCACGTCAATGTCTCAGTAAAAGACACTATAGATAGTTATGGACAATACACTCCAAG
AATACTGGGCTTATGGGTGGGTTGGTTTTTTGTTTTGTTTTGTTTTGTTTTCAAGTCATGTCTTTATCCCCATATAATGGAGAATGTGCC
ACTTGGCTAATAATGTGTTTTCAAAACTACAAGTTCAGTGATGACAGGAAAGAGGGCTAAAGTAGTCCCACAGAGGCTGGTAGAAAAGGC
GAATCACACTTAAGCACCAGCAGGTTAAAAACCTGAAAGGGTGGCCCTGACAATTCAGACTATAGGTTTTACAGCATGCCACTTGTGCAA
TAGGAGGTCTAGGGTTGAAACTTTCAAGAACGAGAGGAGGTGAAGGAAGGAGACGTTTACTGCTCAAATGCCATGCATTTCACTGCTTGC
CACTGAACTTGTATTTGAATGACTTAGTAATGCTTAATATAATTGGGCAACTTTTTTAGCACTTTGGAAAGAGTCATCAATCTTTCTGGT
AAATTATAAAAGTTTTCTGAGTGAGAAAAGGTGTGTTTGGAGTTTGTTTGACTTTTTATATTATTATTGTTATTAATAAAGAAAAAAATC
TACAGCATTTTTCAGACTCCACCCTAGAAAATATGTACCCCTGAATTTGGTTTGCAGTTTGATACTCAGGGAAGGATGTATTCCATAGAT
ATCCTTTCCGTATAAAACACTAACATCTTTGAGAAATTCACCTACCAACTAACTTCAATTGTTGTCACTATGCATTCTTCAATGAAAACT
AGCTTATTTTTCCATATAGTAATGCAGTTAGGGTTCTCAGCACTTTCTTTCTTCTATCCTTTTTTTAACTCTTCATATTATGTTCAGATG
ATCATACTGTCAAGGTTTGTGTACATTACTGAAAATTTGTATTGTATAAAGCTTTTTGCATTACGAGGCTGTACAGGGTCATTTTGACAG
TAACTGGTATATTCCTTTGCATCTTATGTTGCATTGCCAATTTCTAGTGTATCCAGTTTGAAAGTATAATATACTCTAATTAAAAAAAAA

>10873_10873_2_C12orf5-ZNF827_C12orf5_chr12_4430469_ENST00000179259_ZNF827_chr4_146744677_ENST00000508784_length(amino acids)=332AA_BP=11
MARFALTVVRHPFFSEDTFRQSPFTSNSKELLPSDSVLHGRISAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLH
TEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSI
CCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLSALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGF

--------------------------------------------------------------
>10873_10873_3_C12orf5-ZNF827_C12orf5_chr12_4430469_ENST00000179259_ZNF827_chr4_146744677_ENST00000513320_length(transcript)=1953nt_BP=99nt
GGGGAGGTAGCCCGCAGTGCAGGGGCAGCGCGGCGCGGGGCCACCGACGGGACGCGGCTCCGGGAACATGGCTCGCTTCGCTCTGACTGT
TGTCCGGCACCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAACTGCTGCCCAGTGACTCCGTGCT
GCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCCTGGAAATTCAATGACCAGCTTTT
TCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCACACAGAGGAAAGAAAATACAAATG
CCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTGAAGCTGGTGAGTACAGACACCGA
GGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGTCACGTGTGTGGATTTGAGACCGA
GCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATCTGCTGCACTGCCTGCGACTTCGT
CACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACCCCCAGCGAATCAAATAGCCCCTC
TTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAAAACAAGGGCGGGAACAATCTGCT
GGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTCGAATGTGTTTTTTGCAACTTTGT
CTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGTGATGTGTGCCACAAGTTCATGAA
GACCCCCGAACAGCTGCTGGAGCATAAGAAATGCCACACTGTCCCCACCGGTGGGCTCAACTCAGGACAGTGGTGAGTTTCAGACTCCTC
TAGGTGCCCATTCTGCATTTATTCCACCAACCGCCCCGCTGCCATGGAGTGCCACCTCAAGACCCACTACAAGATGGAGTACAAGTGCCG
GATCTGCCAGACGGTGAAGGCCAACCAGCTGGAGCTGGAGACGCACACCCGGGAGCACCGCCTGGGCAACCACTACAAGTGCGACCAGTG
CGGCTACCTGTCCAAGACCGCCAACAAGCTCATCGAGCACGTGCGCGTCCACACCGGGGAGCGGCCCTTCCACTGTGACCAGTGCAGCTA
CAGCTGCAAGCGCAAGGACAATCTCAACCTGCACAAGAAGCTGAAGCACGCCCCACGCCAGACCTTCAGCTGCGAAGAGTGCCTGTTCAA
GACCACACACCCTTTCGTCTTCAGCCGCCACGTCAAGAAGCACCAGAGTGGGGACTGCCCCGAGGAGGACAAGAAGGGCCTGTGTCCAGC
CCCCAAGGAACCGGCCGGCCCGGGGGCCCCGCTCCTGGTGGTCGGGAGCTCCCGGAATCTCCTGTCTCCCCTGTCAGTTATGTCTGCCTC
CCAGGCTCTGCAGACCGTGGCCCTGTCGGCAGCCCACGGCAGCAGCTCAGAGCCCAACCTGGCACTCAAGGCTTTGGCCTTCAACGGCTC
CCCTTTGCGCTTTGACAAGTACCGGAACTCAGATTTTGCCCATCTCATTCCCTTGACAATGTTATACCCCAAGAACCACTTGGATCTCAC
ATTCCACCCTCCCCGACCTCAGACTGCGCCTCCCAGCATCCCCTCACCCAAACACTCCTTCCTGGCCTATCTCGGACTGAGAGAAAGAGC

>10873_10873_3_C12orf5-ZNF827_C12orf5_chr12_4430469_ENST00000179259_ZNF827_chr4_146744677_ENST00000513320_length(amino acids)=332AA_BP=11
MARFALTVVRHPFFSEDTFRQSPFTSNSKELLPSDSVLHGRISAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLH
TEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSI
CCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLSALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TIGAR-ZNF827


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TIGAR-ZNF827


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TIGAR-ZNF827


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource