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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CAMK1D-ZMIZ1 (FusionGDB2 ID:HG57118TG57178) |
Fusion Gene Summary for CAMK1D-ZMIZ1 |
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Fusion gene information | Fusion gene name: CAMK1D-ZMIZ1 | Fusion gene ID: hg57118tg57178 | Hgene | Tgene | Gene symbol | CAMK1D | ZMIZ1 | Gene ID | 57118 | 57178 |
Gene name | calcium/calmodulin dependent protein kinase ID | zinc finger MIZ-type containing 1 | |
Synonyms | CKLiK|CaM-K1|CaMKID | MIZ|NEDDFSA|RAI17|TRAFIP10|ZIMP10 | |
Cytomap | ('CAMK1D')('ZMIZ1') 10p13 | 10q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | zinc finger MIZ domain-containing protein 1retinoic acid induced 17zinc finger-containing, Miz1, PIAS-like protein on chromosome 10 | |
Modification date | 20200313 | 20200315 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000378845, ENST00000378847, ENST00000487696, | ||
Fusion gene scores | * DoF score | 24 X 22 X 7=3696 | 7 X 8 X 5=280 |
# samples | 28 | 8 | |
** MAII score | log2(28/3696*10)=-3.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CAMK1D [Title/Abstract] AND ZMIZ1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CAMK1D(12811798)-ZMIZ1(80878671), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
Tgene | ZMIZ1 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 16777850 |
Tgene | ZMIZ1 | GO:0030521 | androgen receptor signaling pathway | 14609956 |
Tgene | ZMIZ1 | GO:0033233 | regulation of protein sumoylation | 14609956 |
Tgene | ZMIZ1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 26522984 |
Tgene | ZMIZ1 | GO:0060395 | SMAD protein signal transduction | 16777850 |
Tgene | ZMIZ1 | GO:1903508 | positive regulation of nucleic acid-templated transcription | 14609956|16777850 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ESCA | TCGA-LN-A49P | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
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Fusion Gene ORF analysis for CAMK1D-ZMIZ1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000378845 | ENST00000334512 | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
5CDS-5UTR | ENST00000378847 | ENST00000334512 | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
5CDS-intron | ENST00000378845 | ENST00000446377 | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
5CDS-intron | ENST00000378845 | ENST00000478357 | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
5CDS-intron | ENST00000378847 | ENST00000446377 | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
5CDS-intron | ENST00000378847 | ENST00000478357 | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
intron-5UTR | ENST00000487696 | ENST00000334512 | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
intron-intron | ENST00000487696 | ENST00000446377 | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
intron-intron | ENST00000487696 | ENST00000478357 | CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CAMK1D-ZMIZ1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + | 0.18017416 | 0.8198258 |
CAMK1D | chr10 | 12811798 | + | ZMIZ1 | chr10 | 80878671 | + | 0.18017416 | 0.8198258 |
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Fusion Protein Features for CAMK1D-ZMIZ1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:12811798/:80878671) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CAMK1D-ZMIZ1 |
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Fusion Gene PPI Analysis for CAMK1D-ZMIZ1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CAMK1D-ZMIZ1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CAMK1D-ZMIZ1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0025958 | Microcephaly | 2 | GENOMICS_ENGLAND | |
Tgene | C0232466 | Feeding difficulties | 2 | GENOMICS_ENGLAND | |
Tgene | C0243050 | Cardiovascular Abnormalities | 2 | GENOMICS_ENGLAND | |
Tgene | C0262361 | Growth abnormality | 2 | GENOMICS_ENGLAND | |
Tgene | C0557874 | Global developmental delay | 2 | GENOMICS_ENGLAND | |
Tgene | C3714756 | Intellectual Disability | 2 | GENOMICS_ENGLAND | |
Tgene | C4021790 | Abnormality of the skeletal system | 2 | GENOMICS_ENGLAND | |
Tgene | C4021817 | Abnormality of head or neck | 2 | GENOMICS_ENGLAND | |
Tgene | C4021821 | Abnormality of the urinary system | 2 | GENOMICS_ENGLAND | |
Tgene | C0007570 | Celiac Disease | 1 | CTD_human | |
Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human | |
Tgene | C0036572 | Seizures | 1 | GENOMICS_ENGLAND |