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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC44A2-LDLR (FusionGDB2 ID:HG57153TG3949)

Fusion Gene Summary for SLC44A2-LDLR

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC44A2-LDLR
Fusion gene ID: hg57153tg3949
HgeneTgene
Gene symbol

SLC44A2

LDLR

Gene ID

57153

3949

Gene namesolute carrier family 44 member 2low density lipoprotein receptor
SynonymsCTL2|PP1292FH|FHC|FHCL1|LDLCQ2
Cytomap('SLC44A2')('LDLR')

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptioncholine transporter-like protein 2solute carrier family 44 (choline transporter), member 2testicular tissue protein Li 47low-density lipoprotein receptorLDL receptorlow-density lipoprotein receptor class A domain-containing protein 3
Modification date2020031320200322
UniProtAcc.

P01130

Ensembl transtripts involved in fusion geneENST00000335757, ENST00000407327, 
ENST00000586078, ENST00000588214, 
Fusion gene scores* DoF score11 X 9 X 6=5944 X 6 X 4=96
# samples 115
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC44A2 [Title/Abstract] AND LDLR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC44A2(10746191)-LDLR(11241957), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC44A2-LDLR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC44A2-LDLR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC44A2-LDLR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC44A2-LDLR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC44A2-LDLR seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SLC44A2-LDLR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC44A2-LDLR seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SLC44A2-LDLR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC44A2

GO:0015871

choline transport

20410607

HgeneSLC44A2

GO:0055085

transmembrane transport

20410607


check buttonFusion gene breakpoints across SLC44A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LDLR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5JA-01ASLC44A2chr19

10746191

+LDLRchr19

11241957

+


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Fusion Gene ORF analysis for SLC44A2-LDLR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000335757ENST00000560628SLC44A2chr19

10746191

+LDLRchr19

11241957

+
5CDS-intronENST00000407327ENST00000560628SLC44A2chr19

10746191

+LDLRchr19

11241957

+
5CDS-intronENST00000586078ENST00000560628SLC44A2chr19

10746191

+LDLRchr19

11241957

+
Frame-shiftENST00000335757ENST00000557933SLC44A2chr19

10746191

+LDLRchr19

11241957

+
Frame-shiftENST00000335757ENST00000558013SLC44A2chr19

10746191

+LDLRchr19

11241957

+
Frame-shiftENST00000335757ENST00000558518SLC44A2chr19

10746191

+LDLRchr19

11241957

+
Frame-shiftENST00000407327ENST00000557933SLC44A2chr19

10746191

+LDLRchr19

11241957

+
Frame-shiftENST00000407327ENST00000558013SLC44A2chr19

10746191

+LDLRchr19

11241957

+
Frame-shiftENST00000407327ENST00000558518SLC44A2chr19

10746191

+LDLRchr19

11241957

+
Frame-shiftENST00000586078ENST00000557933SLC44A2chr19

10746191

+LDLRchr19

11241957

+
Frame-shiftENST00000586078ENST00000558013SLC44A2chr19

10746191

+LDLRchr19

11241957

+
Frame-shiftENST00000586078ENST00000558518SLC44A2chr19

10746191

+LDLRchr19

11241957

+
In-frameENST00000335757ENST00000455727SLC44A2chr19

10746191

+LDLRchr19

11241957

+
In-frameENST00000335757ENST00000535915SLC44A2chr19

10746191

+LDLRchr19

11241957

+
In-frameENST00000335757ENST00000545707SLC44A2chr19

10746191

+LDLRchr19

11241957

+
In-frameENST00000407327ENST00000455727SLC44A2chr19

10746191

+LDLRchr19

11241957

+
In-frameENST00000407327ENST00000535915SLC44A2chr19

10746191

+LDLRchr19

11241957

+
In-frameENST00000407327ENST00000545707SLC44A2chr19

10746191

+LDLRchr19

11241957

+
In-frameENST00000586078ENST00000455727SLC44A2chr19

10746191

+LDLRchr19

11241957

+
In-frameENST00000586078ENST00000535915SLC44A2chr19

10746191

+LDLRchr19

11241957

+
In-frameENST00000586078ENST00000545707SLC44A2chr19

10746191

+LDLRchr19

11241957

+
intron-3CDSENST00000588214ENST00000455727SLC44A2chr19

10746191

+LDLRchr19

11241957

+
intron-3CDSENST00000588214ENST00000535915SLC44A2chr19

10746191

+LDLRchr19

11241957

+
intron-3CDSENST00000588214ENST00000545707SLC44A2chr19

10746191

+LDLRchr19

11241957

+
intron-3CDSENST00000588214ENST00000557933SLC44A2chr19

10746191

+LDLRchr19

11241957

+
intron-3CDSENST00000588214ENST00000558013SLC44A2chr19

10746191

+LDLRchr19

11241957

+
intron-3CDSENST00000588214ENST00000558518SLC44A2chr19

10746191

+LDLRchr19

11241957

+
intron-intronENST00000588214ENST00000560628SLC44A2chr19

10746191

+LDLRchr19

11241957

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000407327SLC44A2chr1910746191+ENST00000455727LDLRchr1911241957+14521248211283420
ENST00000407327SLC44A2chr1910746191+ENST00000535915LDLRchr1911241957+15061248211283420
ENST00000407327SLC44A2chr1910746191+ENST00000545707LDLRchr1911241957+15781248211283420
ENST00000335757SLC44A2chr1910746191+ENST00000455727LDLRchr1911241957+181316092651644459
ENST00000335757SLC44A2chr1910746191+ENST00000535915LDLRchr1911241957+186716092651644459
ENST00000335757SLC44A2chr1910746191+ENST00000545707LDLRchr1911241957+193916092651644459
ENST00000586078SLC44A2chr1910746191+ENST00000455727LDLRchr1911241957+154613421091377422
ENST00000586078SLC44A2chr1910746191+ENST00000535915LDLRchr1911241957+160013421091377422
ENST00000586078SLC44A2chr1910746191+ENST00000545707LDLRchr1911241957+167213421091377422

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407327ENST00000455727SLC44A2chr1910746191+LDLRchr1911241957+0.0022585430.99774146
ENST00000407327ENST00000535915SLC44A2chr1910746191+LDLRchr1911241957+0.0021081770.99789184
ENST00000407327ENST00000545707SLC44A2chr1910746191+LDLRchr1911241957+0.0019884520.99801147
ENST00000335757ENST00000455727SLC44A2chr1910746191+LDLRchr1911241957+0.0035724350.9964276
ENST00000335757ENST00000535915SLC44A2chr1910746191+LDLRchr1911241957+0.0031946980.9968053
ENST00000335757ENST00000545707SLC44A2chr1910746191+LDLRchr1911241957+0.0029888490.9970112
ENST00000586078ENST00000455727SLC44A2chr1910746191+LDLRchr1911241957+0.0035771590.9964228
ENST00000586078ENST00000535915SLC44A2chr1910746191+LDLRchr1911241957+0.0033199260.99668014
ENST00000586078ENST00000545707SLC44A2chr1910746191+LDLRchr1911241957+0.0031287930.9968712

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Fusion Genomic Features for SLC44A2-LDLR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC44A2chr1910746191+LDLRchr1911241962+1.85E-081
SLC44A2chr1910746191+LDLRchr1911241962+1.85E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC44A2-LDLR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10746191/chr19:11241957)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LDLR

P01130

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. {ECO:0000269|PubMed:3005267, ECO:0000269|PubMed:6091915}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. {ECO:0000269|PubMed:10535997, ECO:0000269|PubMed:12615904}.; FUNCTION: (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. {ECO:0000269|PubMed:23589850}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. {ECO:0000269|PubMed:11100124}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+14221_33411707.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422254_256411707.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422278_315411707.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422337_364411707.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+142255_232411707.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+14221_33409705.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422254_256409705.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422278_315409705.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422337_364409705.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+142255_232409705.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+14221_33411712.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422254_256411712.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422278_315411712.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422337_364411712.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+142255_232411712.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422233_253411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422257_277411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422316_336411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+142234_54411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422365_385411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422233_253409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422257_277409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422316_336409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+142234_54409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422365_385409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422233_253411712.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422257_277411712.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422316_336411712.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+142234_54411712.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422365_385411712.0TransmembraneHelical
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416823_828681693.0MotifNPXY motif
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517823_828808820.0MotifNPXY motif
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416823_828671683.0MotifNPXY motif
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416721_768681693.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416811_860681693.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517811_860808820.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416721_768671683.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416811_860671683.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416789_810681693.0TransmembraneHelical
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416789_810671683.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422386_457411707.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422481_504411707.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422526_563411707.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422585_599411707.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422621_638411707.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422660_706411707.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422386_457409705.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422481_504409705.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422526_563409705.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422585_599409705.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422621_638409705.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422660_706409705.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422386_457411712.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422481_504411712.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422526_563411712.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422585_599411712.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422621_638411712.0Topological domainExtracellular
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422660_706411712.0Topological domainCytoplasmic
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422458_480411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422505_525411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422564_584411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422600_620411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000335757+1422639_659411707.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422458_480409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422505_525409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422564_584409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422600_620409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000407327+1422639_659409705.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422458_480411712.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422505_525411712.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422564_584411712.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422600_620411712.0TransmembraneHelical
HgeneSLC44A2chr19:10746191chr19:11241957ENST00000586078+1422639_659411712.0TransmembraneHelical
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416107_145681693.0DomainLDL-receptor class A 3
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416146_186681693.0DomainLDL-receptor class A 4
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416195_233681693.0DomainLDL-receptor class A 5
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416234_272681693.0DomainLDL-receptor class A 6
TgeneLDLRchr19:10746191chr19:11241957ENST00000455727141625_65681693.0DomainLDL-receptor class A 1
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416274_313681693.0DomainLDL-receptor class A 7
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416314_353681693.0DomainEGF-like 1
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416354_393681693.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416663_712681693.0DomainEGF-like 3
TgeneLDLRchr19:10746191chr19:11241957ENST00000455727141666_106681693.0DomainLDL-receptor class A 2
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517107_145808820.0DomainLDL-receptor class A 3
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517146_186808820.0DomainLDL-receptor class A 4
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517195_233808820.0DomainLDL-receptor class A 5
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517234_272808820.0DomainLDL-receptor class A 6
TgeneLDLRchr19:10746191chr19:11241957ENST00000535915151725_65808820.0DomainLDL-receptor class A 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517274_313808820.0DomainLDL-receptor class A 7
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517314_353808820.0DomainEGF-like 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517354_393808820.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517663_712808820.0DomainEGF-like 3
TgeneLDLRchr19:10746191chr19:11241957ENST00000535915151766_106808820.0DomainLDL-receptor class A 2
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416107_145671683.0DomainLDL-receptor class A 3
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416146_186671683.0DomainLDL-receptor class A 4
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416195_233671683.0DomainLDL-receptor class A 5
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416234_272671683.0DomainLDL-receptor class A 6
TgeneLDLRchr19:10746191chr19:11241957ENST00000545707141625_65671683.0DomainLDL-receptor class A 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416274_313671683.0DomainLDL-receptor class A 7
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416314_353671683.0DomainEGF-like 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416354_393671683.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416663_712671683.0DomainEGF-like 3
TgeneLDLRchr19:10746191chr19:11241957ENST00000545707141666_106671683.0DomainLDL-receptor class A 2
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618107_145849859.0DomainLDL-receptor class A 3
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618146_186849859.0DomainLDL-receptor class A 4
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618195_233849859.0DomainLDL-receptor class A 5
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618234_272849859.0DomainLDL-receptor class A 6
TgeneLDLRchr19:10746191chr19:11241957ENST00000558013161825_65849859.0DomainLDL-receptor class A 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618274_313849859.0DomainLDL-receptor class A 7
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618314_353849859.0DomainEGF-like 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618354_393849859.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618663_712849859.0DomainEGF-like 3
TgeneLDLRchr19:10746191chr19:11241957ENST00000558013161866_106849859.0DomainLDL-receptor class A 2
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618107_145849861.0DomainLDL-receptor class A 3
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618146_186849861.0DomainLDL-receptor class A 4
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618195_233849861.0DomainLDL-receptor class A 5
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618234_272849861.0DomainLDL-receptor class A 6
TgeneLDLRchr19:10746191chr19:11241957ENST00000558518161825_65849861.0DomainLDL-receptor class A 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618274_313849861.0DomainLDL-receptor class A 7
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618314_353849861.0DomainEGF-like 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618354_393849861.0DomainEGF-like 2%3B calcium-binding
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618663_712849861.0DomainEGF-like 3
TgeneLDLRchr19:10746191chr19:11241957ENST00000558518161866_106849861.0DomainLDL-receptor class A 2
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618823_828849859.0MotifNPXY motif
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618823_828849861.0MotifNPXY motif
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517721_768808820.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618721_768849859.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618811_860849859.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618721_768849861.0RegionNote=Clustered O-linked oligosaccharides
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618811_860849861.0RegionRequired for MYLIP-triggered down-regulation of LDLR
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416397_438681693.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416439_485681693.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416486_528681693.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416529_572681693.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416573_615681693.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:10746191chr19:11241957ENST000004557271416616_658681693.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517397_438808820.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517439_485808820.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517486_528808820.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517529_572808820.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517573_615808820.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517616_658808820.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416397_438671683.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416439_485671683.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416486_528671683.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416529_572671683.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416573_615671683.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:10746191chr19:11241957ENST000005457071416616_658671683.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618397_438849859.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618439_485849859.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618486_528849859.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618529_572849859.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618573_615849859.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618616_658849859.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618397_438849861.0RepeatNote=LDL-receptor class B 1
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618439_485849861.0RepeatNote=LDL-receptor class B 2
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618486_528849861.0RepeatNote=LDL-receptor class B 3
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618529_572849861.0RepeatNote=LDL-receptor class B 4
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618573_615849861.0RepeatNote=LDL-receptor class B 5
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618616_658849861.0RepeatNote=LDL-receptor class B 6
TgeneLDLRchr19:10746191chr19:11241957ENST00000455727141622_788681693.0Topological domainExtracellular
TgeneLDLRchr19:10746191chr19:11241957ENST00000535915151722_788808820.0Topological domainExtracellular
TgeneLDLRchr19:10746191chr19:11241957ENST00000545707141622_788671683.0Topological domainExtracellular
TgeneLDLRchr19:10746191chr19:11241957ENST00000558013161822_788849859.0Topological domainExtracellular
TgeneLDLRchr19:10746191chr19:11241957ENST00000558518161822_788849861.0Topological domainExtracellular
TgeneLDLRchr19:10746191chr19:11241957ENST000005359151517789_810808820.0TransmembraneHelical
TgeneLDLRchr19:10746191chr19:11241957ENST000005580131618789_810849859.0TransmembraneHelical
TgeneLDLRchr19:10746191chr19:11241957ENST000005585181618789_810849861.0TransmembraneHelical


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Fusion Gene Sequence for SLC44A2-LDLR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83293_83293_1_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000335757_LDLR_chr19_11241957_ENST00000455727_length(transcript)=1813nt_BP=1609nt
CTCAGTTTCCACACCTGCAAAACGAAGCCACGGAAACGCCCTTTCAGGGTGGCCAGGGGTTCTAGGCGGCATCGCCCGGTGGCAGGGTGT
TCCCAGGGTGAAGCCGCAGGGTTCCCGGGTGGGGGCGGGGAAGGCTAAATGCGGCCGGCCGGTGAGTGGCGGGAGCAGCTGCAGCCCCGC
CCGCGCCCTCCCGGGTCCCTTAGTCTGGGCAGCTGCCCAGCTCGGGCCGGTCTGACCGGTTTGGGCCGCCCCGCCTGGCGCTGTGCTGGG
AGGAGCCGCCGCCAGTCGCGCGGTCAGTGCCTCCCTCCAGACTCGGGAGGGTCGAGGGGGCGCGGGAGAGAGCGCGGGCGGCCGCCGGGG
CTGGTCGCCTGCAGGGATGGGGGACGAGCGGCCCCACTACTACGGGAAACACGGAACGCCACAGAAGTATGATCCCACTTTCAAAGGACC
CATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGCCTG
GACTCATGGAGACCCTCGAAAGGTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAGAACAAACC
CTATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGAAAA
ATGCCCCGACCGCTACCTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGCTTCAAGAA
CAATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCCCGC
TATCCACGCCTACAAGGGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACAGACCTGGT
GGAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTGGAT
TATCATAGGCCTGGTCATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGGGTGATGAT
CATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGTCTC
TTTGGTGGACCTCGGCTTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTGAGTATCCT
TGAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGTGGG
ATACGTCATGTGCTCCTTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCTGTCTTCCT
GTCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCATTTACTGCGAAAACCTGCAACCCAGAGAGACAGATGGT
CAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATT
CAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCC

>83293_83293_1_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000335757_LDLR_chr19_11241957_ENST00000455727_length(amino acids)=459AA_BP=
MGGAAASRAVSASLQTREGRGGAGESAGGRRGWSPAGMGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGII
AWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGF
KNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWY
WIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILS
ILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSPCPFTAKTCNPERQ

--------------------------------------------------------------
>83293_83293_2_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000335757_LDLR_chr19_11241957_ENST00000535915_length(transcript)=1867nt_BP=1609nt
CTCAGTTTCCACACCTGCAAAACGAAGCCACGGAAACGCCCTTTCAGGGTGGCCAGGGGTTCTAGGCGGCATCGCCCGGTGGCAGGGTGT
TCCCAGGGTGAAGCCGCAGGGTTCCCGGGTGGGGGCGGGGAAGGCTAAATGCGGCCGGCCGGTGAGTGGCGGGAGCAGCTGCAGCCCCGC
CCGCGCCCTCCCGGGTCCCTTAGTCTGGGCAGCTGCCCAGCTCGGGCCGGTCTGACCGGTTTGGGCCGCCCCGCCTGGCGCTGTGCTGGG
AGGAGCCGCCGCCAGTCGCGCGGTCAGTGCCTCCCTCCAGACTCGGGAGGGTCGAGGGGGCGCGGGAGAGAGCGCGGGCGGCCGCCGGGG
CTGGTCGCCTGCAGGGATGGGGGACGAGCGGCCCCACTACTACGGGAAACACGGAACGCCACAGAAGTATGATCCCACTTTCAAAGGACC
CATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGCCTG
GACTCATGGAGACCCTCGAAAGGTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAGAACAAACC
CTATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGAAAA
ATGCCCCGACCGCTACCTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGCTTCAAGAA
CAATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCCCGC
TATCCACGCCTACAAGGGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACAGACCTGGT
GGAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTGGAT
TATCATAGGCCTGGTCATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGGGTGATGAT
CATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGTCTC
TTTGGTGGACCTCGGCTTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTGAGTATCCT
TGAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGTGGG
ATACGTCATGTGCTCCTTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCTGTCTTCCT
GTCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCATTTACTGCGAAAACCTGCAACCCAGAGAGACAGATGGT
CAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATT
CAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCC

>83293_83293_2_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000335757_LDLR_chr19_11241957_ENST00000535915_length(amino acids)=459AA_BP=
MGGAAASRAVSASLQTREGRGGAGESAGGRRGWSPAGMGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGII
AWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGF
KNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWY
WIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILS
ILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSPCPFTAKTCNPERQ

--------------------------------------------------------------
>83293_83293_3_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000335757_LDLR_chr19_11241957_ENST00000545707_length(transcript)=1939nt_BP=1609nt
CTCAGTTTCCACACCTGCAAAACGAAGCCACGGAAACGCCCTTTCAGGGTGGCCAGGGGTTCTAGGCGGCATCGCCCGGTGGCAGGGTGT
TCCCAGGGTGAAGCCGCAGGGTTCCCGGGTGGGGGCGGGGAAGGCTAAATGCGGCCGGCCGGTGAGTGGCGGGAGCAGCTGCAGCCCCGC
CCGCGCCCTCCCGGGTCCCTTAGTCTGGGCAGCTGCCCAGCTCGGGCCGGTCTGACCGGTTTGGGCCGCCCCGCCTGGCGCTGTGCTGGG
AGGAGCCGCCGCCAGTCGCGCGGTCAGTGCCTCCCTCCAGACTCGGGAGGGTCGAGGGGGCGCGGGAGAGAGCGCGGGCGGCCGCCGGGG
CTGGTCGCCTGCAGGGATGGGGGACGAGCGGCCCCACTACTACGGGAAACACGGAACGCCACAGAAGTATGATCCCACTTTCAAAGGACC
CATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGCCTG
GACTCATGGAGACCCTCGAAAGGTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAGAACAAACC
CTATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGAAAA
ATGCCCCGACCGCTACCTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGCTTCAAGAA
CAATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCCCGC
TATCCACGCCTACAAGGGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACAGACCTGGT
GGAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTGGAT
TATCATAGGCCTGGTCATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGGGTGATGAT
CATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGTCTC
TTTGGTGGACCTCGGCTTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTGAGTATCCT
TGAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGTGGG
ATACGTCATGTGCTCCTTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCTGTCTTCCT
GTCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCATTTACTGCGAAAACCTGCAACCCAGAGAGACAGATGGT
CAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATT
CAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCC
CATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCC

>83293_83293_3_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000335757_LDLR_chr19_11241957_ENST00000545707_length(amino acids)=459AA_BP=
MGGAAASRAVSASLQTREGRGGAGESAGGRRGWSPAGMGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGII
AWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGF
KNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWY
WIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILS
ILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSPCPFTAKTCNPERQ

--------------------------------------------------------------
>83293_83293_4_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000407327_LDLR_chr19_11241957_ENST00000455727_length(transcript)=1452nt_BP=1248nt
GCTCCCCGCCCCGCCGCGGCCATGGAGGACGAGCGGAAAAACGGAGCCTACGGAACGCCACAGAAGTATGATCCCACTTTCAAAGGACCC
ATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGCCTGG
ACTCATGGAGACCCTCGAAAGGTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAGAACAAACCC
TATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGAAAAA
TGCCCCGACCGCTACCTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGCTTCAAGAAC
AATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCCCGCT
ATCCACGCCTACAAGGGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACAGACCTGGTG
GAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTGGATT
ATCATAGGCCTGGTCATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGGGTGATGATC
ATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGTCTCT
TTGGTGGACCTCGGCTTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTGAGTATCCTT
GAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGTGGGA
TACGTCATGTGCTCCTTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCTGTCTTCCTG
TCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCATTTACTGCGAAAACCTGCAACCCAGAGAGACAGATGGTC
AGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTC
AAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCC

>83293_83293_4_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000407327_LDLR_chr19_11241957_ENST00000455727_length(amino acids)=420AA_BP=
MEDERKNGAYGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNI
VKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGV
LMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVL
GYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLL

--------------------------------------------------------------
>83293_83293_5_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000407327_LDLR_chr19_11241957_ENST00000535915_length(transcript)=1506nt_BP=1248nt
GCTCCCCGCCCCGCCGCGGCCATGGAGGACGAGCGGAAAAACGGAGCCTACGGAACGCCACAGAAGTATGATCCCACTTTCAAAGGACCC
ATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGCCTGG
ACTCATGGAGACCCTCGAAAGGTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAGAACAAACCC
TATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGAAAAA
TGCCCCGACCGCTACCTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGCTTCAAGAAC
AATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCCCGCT
ATCCACGCCTACAAGGGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACAGACCTGGTG
GAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTGGATT
ATCATAGGCCTGGTCATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGGGTGATGATC
ATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGTCTCT
TTGGTGGACCTCGGCTTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTGAGTATCCTT
GAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGTGGGA
TACGTCATGTGCTCCTTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCTGTCTTCCTG
TCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCATTTACTGCGAAAACCTGCAACCCAGAGAGACAGATGGTC
AGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTC
AAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCC

>83293_83293_5_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000407327_LDLR_chr19_11241957_ENST00000535915_length(amino acids)=420AA_BP=
MEDERKNGAYGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNI
VKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGV
LMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVL
GYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLL

--------------------------------------------------------------
>83293_83293_6_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000407327_LDLR_chr19_11241957_ENST00000545707_length(transcript)=1578nt_BP=1248nt
GCTCCCCGCCCCGCCGCGGCCATGGAGGACGAGCGGAAAAACGGAGCCTACGGAACGCCACAGAAGTATGATCCCACTTTCAAAGGACCC
ATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGCCTGG
ACTCATGGAGACCCTCGAAAGGTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAGAACAAACCC
TATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGAAAAA
TGCCCCGACCGCTACCTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGCTTCAAGAAC
AATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCCCGCT
ATCCACGCCTACAAGGGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACAGACCTGGTG
GAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTGGATT
ATCATAGGCCTGGTCATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGGGTGATGATC
ATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGTCTCT
TTGGTGGACCTCGGCTTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTGAGTATCCTT
GAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGTGGGA
TACGTCATGTGCTCCTTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCTGTCTTCCTG
TCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCATTTACTGCGAAAACCTGCAACCCAGAGAGACAGATGGTC
AGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTC
AAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCC
ATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCA

>83293_83293_6_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000407327_LDLR_chr19_11241957_ENST00000545707_length(amino acids)=420AA_BP=
MEDERKNGAYGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNI
VKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGV
LMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVL
GYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLL

--------------------------------------------------------------
>83293_83293_7_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000586078_LDLR_chr19_11241957_ENST00000455727_length(transcript)=1546nt_BP=1342nt
GGGAGGAGCCGCCGCCAGTCGCGCGGTCAGTGCCTCCCTCCAGACTCGGGAGGGTCGAGGGGGCGCGGGAGAGAGCGCGGGCGGCCGCCG
GGGCTGGTCGCCTGCAGGGATGGGGGACGAGCGGCCCCACTACTACGGGAAACACGGAACGCCACAGAAGTATGATCCCACTTTCAAAGG
ACCCATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGC
CTGGACTCATGGAGACCCTCGAAAGGTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAGAACAA
ACCCTATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGA
AAAATGCCCCGACCGCTACCTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGCTTCAA
GAACAATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCC
CGCTATCCACGCCTACAAGGGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACAGACCT
GGTGGAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTG
GATTATCATAGGCCTGGTCATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGGGTGAT
GATCATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGT
CTCTTTGGTGGACCTCGGCTTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTGAGTAT
CCTTGAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGT
GGGATACGTCATGTGCTCCTTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCTGTCTT
CCTGTCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCATTTACTGCGAAAACCTGCAACCCAGAGAGACAGAT
GGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTT
ATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGT

>83293_83293_7_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000586078_LDLR_chr19_11241957_ENST00000455727_length(amino acids)=422AA_BP=
MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYF
NIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYK
GVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVIL
VLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCS

--------------------------------------------------------------
>83293_83293_8_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000586078_LDLR_chr19_11241957_ENST00000535915_length(transcript)=1600nt_BP=1342nt
GGGAGGAGCCGCCGCCAGTCGCGCGGTCAGTGCCTCCCTCCAGACTCGGGAGGGTCGAGGGGGCGCGGGAGAGAGCGCGGGCGGCCGCCG
GGGCTGGTCGCCTGCAGGGATGGGGGACGAGCGGCCCCACTACTACGGGAAACACGGAACGCCACAGAAGTATGATCCCACTTTCAAAGG
ACCCATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGC
CTGGACTCATGGAGACCCTCGAAAGGTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAGAACAA
ACCCTATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGA
AAAATGCCCCGACCGCTACCTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGCTTCAA
GAACAATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCC
CGCTATCCACGCCTACAAGGGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACAGACCT
GGTGGAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTG
GATTATCATAGGCCTGGTCATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGGGTGAT
GATCATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGT
CTCTTTGGTGGACCTCGGCTTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTGAGTAT
CCTTGAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGT
GGGATACGTCATGTGCTCCTTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCTGTCTT
CCTGTCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCATTTACTGCGAAAACCTGCAACCCAGAGAGACAGAT
GGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTT
ATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGT

>83293_83293_8_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000586078_LDLR_chr19_11241957_ENST00000535915_length(amino acids)=422AA_BP=
MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYF
NIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYK
GVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVIL
VLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCS

--------------------------------------------------------------
>83293_83293_9_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000586078_LDLR_chr19_11241957_ENST00000545707_length(transcript)=1672nt_BP=1342nt
GGGAGGAGCCGCCGCCAGTCGCGCGGTCAGTGCCTCCCTCCAGACTCGGGAGGGTCGAGGGGGCGCGGGAGAGAGCGCGGGCGGCCGCCG
GGGCTGGTCGCCTGCAGGGATGGGGGACGAGCGGCCCCACTACTACGGGAAACACGGAACGCCACAGAAGTATGATCCCACTTTCAAAGG
ACCCATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGC
CTGGACTCATGGAGACCCTCGAAAGGTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAGAACAA
ACCCTATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGA
AAAATGCCCCGACCGCTACCTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGCTTCAA
GAACAATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCC
CGCTATCCACGCCTACAAGGGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACAGACCT
GGTGGAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTG
GATTATCATAGGCCTGGTCATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGGGTGAT
GATCATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGT
CTCTTTGGTGGACCTCGGCTTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTGAGTAT
CCTTGAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGT
GGGATACGTCATGTGCTCCTTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCTGTCTT
CCTGTCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCATTTACTGCGAAAACCTGCAACCCAGAGAGACAGAT
GGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTT
ATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGT
GCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACC

>83293_83293_9_SLC44A2-LDLR_SLC44A2_chr19_10746191_ENST00000586078_LDLR_chr19_11241957_ENST00000545707_length(amino acids)=422AA_BP=
MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYF
NIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYK
GVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVIL
VLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC44A2-LDLR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC44A2-LDLR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLDLRP01130DB00707Porfimer sodiumOther/unknownSmall moleculeApproved|Investigational

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Related Diseases for SLC44A2-LDLR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC44A2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0745103Hyperlipoproteinemia Type IIa61CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0020445Hypercholesterolemia, Familial9CTD_human;GENOMICS_ENGLAND
TgeneC1704417Hyperlipoproteinemia Type IIb7CTD_human
TgeneC0020443Hypercholesterolemia6CTD_human;GENOMICS_ENGLAND
TgeneC0004153Atherosclerosis5CTD_human
TgeneC1563937Atherogenesis5CTD_human
TgeneC0400966Non-alcoholic Fatty Liver Disease3CTD_human
TgeneC3241937Nonalcoholic Steatohepatitis3CTD_human
TgeneC0010054Coronary Arteriosclerosis2CTD_human
TgeneC0020473Hyperlipidemia2CTD_human
TgeneC1706412Lipidemias2CTD_human
TgeneC1956346Coronary Artery Disease2CTD_human
TgeneC0010068Coronary heart disease1CTD_human
TgeneC0015695Fatty Liver1CTD_human
TgeneC0020507Hyperplasia1CTD_human
TgeneC0028754Obesity1CTD_human
TgeneC0034362Q Fever1CTD_human
TgeneC0085762Alcohol abuse1PSYGENET
TgeneC0242339Dyslipidemias1CTD_human
TgeneC0519066Acute Q fever1CTD_human
TgeneC0598784Dyslipoproteinemias1CTD_human
TgeneC1443892Chronic Q Fever1CTD_human
TgeneC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneC2711227Steatohepatitis1CTD_human
TgeneC2973787Coxiella burnetii Infection1CTD_human
TgeneC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human