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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ANKRD50-METTL14 (FusionGDB2 ID:HG57182TG57721)

Fusion Gene Summary for ANKRD50-METTL14

Fusion gene summary

Fusion gene information	Fusion gene name: ANKRD50-METTL14
	Fusion gene ID: hg57182tg57721
		Hgene	Tgene
	Gene symbol	ANKRD50	METTL14
	Gene ID	57182	57721
	Gene name	ankyrin repeat domain 50	methyltransferase like 14
	Synonyms	-	hMETTL14
	Cytomap	('ANKRD50')('METTL14') 4q28.1	4q26
	Type of gene	protein-coding	protein-coding
	Description	ankyrin repeat domain-containing protein 50	N6-adenosine-methyltransferase non-catalytic subunitN6-adenosine-methyltransferase subunit METTL14methyltransferase-like protein 14
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000504087, ENST00000515641,
Fusion gene scores	* DoF score	4 X 4 X 3=48	3 X 3 X 3=27
	# samples	4	3
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ANKRD50 [Title/Abstract] AND METTL14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANKRD50(125631154)-METTL14(119609077), # samples:1
Anticipated loss of major functional domain due to fusion event.	ANKRD50-METTL14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ANKRD50-METTL14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ANKRD50-METTL14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ANKRD50-METTL14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	METTL14	GO:0080009	mRNA methylation	27281194\|27373337\|27627798

Fusion gene breakpoints across ANKRD50 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across METTL14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-CK-6746	ANKRD50	chr4	125631154	-	METTL14	chr4	119609077	+

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Fusion Gene ORF analysis for ANKRD50-METTL14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000504087	ENST00000506780	ANKRD50	chr4	125631154	-	METTL14	chr4	119609077	+
In-frame	ENST00000504087	ENST00000388822	ANKRD50	chr4	125631154	-	METTL14	chr4	119609077	+
intron-3CDS	ENST00000515641	ENST00000388822	ANKRD50	chr4	125631154	-	METTL14	chr4	119609077	+
intron-5UTR	ENST00000515641	ENST00000506780	ANKRD50	chr4	125631154	-	METTL14	chr4	119609077	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000504087

ANKRD50

chr4

125631154

ENST00000388822

METTL14

chr4

119609077

7986

1550

2854

434

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000504087	ENST00000388822	ANKRD50	chr4	125631154	-	METTL14	chr4	119609077	+	0.000299749	0.9997003

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Fusion Genomic Features for ANKRD50-METTL14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ANKRD50	chr4	125631154	-	METTL14	chr4	119609077	+	0.004870588	0.99512947
ANKRD50	chr4	125631154	-	METTL14	chr4	119609077	+	0.004870588	0.99512947

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANKRD50-METTL14

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:125631154/chr4:119609077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

METTL14

chr4:125631154

chr4:119609077

ENST00000388822

409_452

457.0

Compositional bias

Note=Gly-rich

Tgene

METTL14

chr4:125631154

chr4:119609077

ENST00000388822

245_254

457.0

Region

Positively charged region required for RNA-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

1123_1292

170

3251.3333333333335

Compositional bias

Note=Ser-rich

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

1123_1292

2318.3333333333335

Compositional bias

Note=Ser-rich

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

1011_1040

170

3251.3333333333335

Repeat

Note=ANK 17

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

1044_1073

170

3251.3333333333335

Repeat

Note=ANK 18

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

1077_1107

170

3251.3333333333335

Repeat

Note=ANK 19

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

477_509

170

3251.3333333333335

Repeat

Note=ANK 1

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

511_540

170

3251.3333333333335

Repeat

Note=ANK 2

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

544_573

170

3251.3333333333335

Repeat

Note=ANK 3

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

577_606

170

3251.3333333333335

Repeat

Note=ANK 4

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

610_639

170

3251.3333333333335

Repeat

Note=ANK 5

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

643_672

170

3251.3333333333335

Repeat

Note=ANK 6

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

676_705

170

3251.3333333333335

Repeat

Note=ANK 7

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

709_743

170

3251.3333333333335

Repeat

Note=ANK 8

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

747_776

170

3251.3333333333335

Repeat

Note=ANK 9

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

780_809

170

3251.3333333333335

Repeat

Note=ANK 10

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

813_842

170

3251.3333333333335

Repeat

Note=ANK 11

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

846_875

170

3251.3333333333335

Repeat

Note=ANK 12

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

879_908

170

3251.3333333333335

Repeat

Note=ANK 13

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

912_941

170

3251.3333333333335

Repeat

Note=ANK 14

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

945_974

170

3251.3333333333335

Repeat

Note=ANK 15

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000504087

978_1007

170

3251.3333333333335

Repeat

Note=ANK 16

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

1011_1040

2318.3333333333335

Repeat

Note=ANK 17

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

1044_1073

2318.3333333333335

Repeat

Note=ANK 18

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

1077_1107

2318.3333333333335

Repeat

Note=ANK 19

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

477_509

2318.3333333333335

Repeat

Note=ANK 1

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

511_540

2318.3333333333335

Repeat

Note=ANK 2

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

544_573

2318.3333333333335

Repeat

Note=ANK 3

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

577_606

2318.3333333333335

Repeat

Note=ANK 4

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

610_639

2318.3333333333335

Repeat

Note=ANK 5

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

643_672

2318.3333333333335

Repeat

Note=ANK 6

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

676_705

2318.3333333333335

Repeat

Note=ANK 7

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

709_743

2318.3333333333335

Repeat

Note=ANK 8

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

747_776

2318.3333333333335

Repeat

Note=ANK 9

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

780_809

2318.3333333333335

Repeat

Note=ANK 10

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

813_842

2318.3333333333335

Repeat

Note=ANK 11

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

846_875

2318.3333333333335

Repeat

Note=ANK 12

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

879_908

2318.3333333333335

Repeat

Note=ANK 13

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

912_941

2318.3333333333335

Repeat

Note=ANK 14

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

945_974

2318.3333333333335

Repeat

Note=ANK 15

Hgene

ANKRD50

chr4:125631154

chr4:119609077

ENST00000515641

978_1007

2318.3333333333335

Repeat

Note=ANK 16

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Fusion Gene Sequence for ANKRD50-METTL14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>4759_4759_1_ANKRD50-METTL14_ANKRD50_chr4_125631154_ENST00000504087_METTL14_chr4_119609077_ENST00000388822_length(transcript)=7986nt_BP=1550nt
AGTTACTGCCCTGACGGCGGCGGCGGCGGCGGTTGGCCGGTGGGGGCTGGGGCGAGCACGACCGATTCTGCTGGGAAAGCTGGAACTGGC
AGCCGCCGGGGGCCAAGAGGAGGATCCGGAGCTGGGAGCGTGCCCCGGGCCCGGCGGAGGAGGCGGCTGCAGTTGGAGTGGAGTCTTGGG
AGCGCTGCTGGCAGCGACTTCTCAGCGAAGCAAGTGTCTGAGACTGAGAGTCCCTAACAGCGGCAGCGGCGGCCACGGCGGCGGCTGGGG
CCGAGTTACTTGTGGAAATTGTTGATTACCCGGACGTCTTAAAACCAAGAAACCTGTGAACAGGTTCATTAAGAATCTGCTGTCTTGAAA
AATGCATATTATGAATGCTTTGAATTAAGAAGGTGTTAACAGTGGTTGTCATTTCTGCCACATAAGAGACTATAATCTGAAACAGTTCCT
GGCAGTTGCCCAGATGCCTGAAACTGGCACGATCTAGTACTCTTGAGTGATCATCCTTCAACGAGAAATACAGAGCTACTTACATACTGT
ACCTCATACCGTATAAATGTAATCTCTCTGATGCCATTTAATGCAGTGGACCTCTTTTCAGAATCTAATTGTCAGATGCAGAATTAACAC
TTGGAATCTGGAGAAGCATTTTGTACAAATTGAAAGATTGGGTTTTTTCTTTAGTTTTCCACATGTATTGTCTCATCTCTGTTCTTGAAA
CATCCACAATCACATAAACTCCAGTTATAACCATGGAGTTATGTGACTCATTAAAATTTAGGAAAAGTGTTGCTGAGCTGTGGAATCAGG
CGTTTCTCCCTCAGTTCAACAACTAATACATAGACTGCTGATCAAGAATAAGGAACCAAATAAAGTCATGCACGTTCTGTTGACAGAGGA
ACTCTGTGGCTGTTGAATTTTACTGTAACTAGTTACTCTGTCTTCAGAGTCAACTTAATATACAAGTTATGTCATAATGGATGGAAAGAC
CTGTGTTGATGTATCCAGACTCTAGCAAATGAAGATAAAAAACCCGTTATGACTAATCCTTGGGAAGAGAAAGTCTGCAAAATGGCTCAA
ACCAGTTTACTGCAAGGGAAGCAGTTTTACTGTAGGGAGTGGGTTTTCCACAAGCTTCAGCATTGCCTCCAGGAGAAAAGTAACTGCTGC
AATAGTGCTGTCAATGCACCATCACTTGTAATGAATTCTGGGAATAATGCTAGTGGTGTCTCTGGAAAGGGAGCTGCCTGGGGTGTGTTG
TTGGTAGGAGGGCCTGGCAGTGGCAAGACGGCCCTATGTACTGAACTCTTATGGCCAAGTTCACCTGCAAGTTTGCAGAGAGGTTTACAT
CGCCAAGCTTTGGCCTTTCATTTCTGCAAAGCCCAGGACTCTGATACTTTGTGTGTTGGAGGGTTTATTAGAGGTCTAGTAGCCCAGATC
TGCCGCAGTGGACTACTCCAAGGATATGAGGACAAGCTAAGGGATCCAGCAGTCCAAAGCCTCTTACAGCCTGGGGAGTGCGAGAGAAAC
CCAGCCGAAGCATTTAAAAGTTGGGAGCTGAAAGTGCCGACAGCATTGGTGCCGTGTTAAATAGCAAAGATGAGCAGAGAGAAATTGCTG
AAACAAGAGAAACTTGCAGGGCTTCCTATGATACCTCTGCTCCAAATGCAAAACGTAAGTATCTGGATGAAGGAGAGACAGATGAAGACA
AAATGGAAGAATATAAGGATGAACTAGAAATGCAACAGGATGAAGAAAATTTGCCATATGAAGAAGAGATTTACAAAGATTCTAGTACTT
TTCTTAAGGGAACACAGAGCTTAAATCCCCATAATGATTACTGCCAACATTTTGTAGACACTGGACATAGACCTCAGAATTTCATCAGGG
ATGTAGGTTTAGCTGACAGATTTGAAGAATATCCTAAACTGAGGGAGCTCATCAGGCTAAAGGATGAGTTAATAGCTAAATCTAACACTC
CTCCCATGTACTTACAAGCCGATATAGAAGCCTTTGACATCAGAGAACTAACACCCAAATTTGATGTGATTCTTCTGGAACCCCCTTTAG
AAGAATATTACAGAGAAACTGGCATCACTGCTAATGAAAAATGCTGGACTTGGGATGATATTATGAAGTTAGAAATTGATGAGATTGCAG
CACCTCGATCATTTATTTTTCTCTGGTGTGGTTCTGGGGAGGGGTTGGACCTTGGAAGAGTGTGTTTACGAAAATGGGGTTACAGAAGAT
GTGAAGATATTTGTTGGATTAAAACCAATAAAAACAATCCTGGGAAGACTAAGACTTTAGATCCAAAGGCTGTCTTTCAGAGAACAAAGG
AACACTGCCTCATGGGGATCAAAGGAACTGTGAAGCGTAGCACAGACGGGGACTTCATTCATGCTAATGTTGACATTGACTTAATTATCA
CAGAAGAACCTGAAATTGGCAATATAGAAAAACCTGTAGAAATTTTTCATATAATTGAGCATTTTTGTCTTGGTAGAAGACGCCTTCATC
TATTTGGAAGAGATAGTACAATTCGACCAGGCTGGCTCACAGTTGGACCAACGCTTACAAATAGCAACTACAATGCAGAAACATATGCAT
CCTATTTCAGTGCTCCTAATTCCTACTTGACTGGTTGTACAGAAGAAATTGAGAGACTTCGACCAAAATCGCCTCCTCCCAAATCTAAAT
CTGACCGAGGAGGTGGAGCTCCCAGAGGTGGAGGAAGAGGTGGAACTTCTGCTGGCCGTGGACGAGAAAGAAATAGATCTAACTTCCGAG
GAGAAAGAGGTGGCTTTAGAGGGGGCCGTGGAGGAGCACACAGAGGTGGCTTTCCACCTCGATAATTGTTGAAGACATTGAACCTATTCA
TCCTCCTCTAACCTTCTTTATTGTAATTAAATTTCAAGTGGGAGACTTAACTTTAGAACTCACTTCCAGCTTGCACTTTGCTTTAATTTC
TCTGAGCTGCAAGAATGTCTTAGCGAGCCTTGCTTGCAGTTGTCACACACACTGTCTGGTTTTTTTCAGGATAAATGAATGATTCTGCCT
TTTGTTATGTGCGTGAACAGAATGGAACAACTCAAGTAGCTTCATCTTCAGAGACTGAATTTATTCTGATAGACTTCAGCTAATTACAAA
GGATTTTGCTAATTTTTGGGAATAAATAATGGAAAAAGATCCAGTCTGTGGTATCATGCTAGTGCTGACAGGGCCTTGATAGAATAGAGT
TGGAAAAGATGGTAAGCTTTTGTCAGGGTTTTAACATTTTCTTGATGAAACAATAAAAAGAGGTAAGCTTTTTTCTTCTTTTTTTTTAAG
TTTTAAATAAACTCAGATATAATTTGAATACTGAAGAAATTAAGAGACTTTGAACAAAAACTCTTCCCAAATCTAAATTTGATAGGGGAG
GTGGAGATTCCAGGGGTGGGTGAAAGAAGAGATAGAACTTAGCAGGCAGACTTAAAAAAAAAAAAAAAGTTTATCATCATAATCTCAATT
TTGTGGCTATGACTCCTAATCACGCTTCCTAAGAAGCAAAGGAGGACAAATATTCATGTGCTAGATAGCACTGTGGTGTGGACTTGAACT
TGGATTGACCTTAAATTTTATATTCCTCAAATAAAAGAGAGGCAGCGACAAGATACCTCATTATCAGATGCTTGGTTTATACATTTTGGG
ACTAAAATACTTGGTGATGAAATGACATACACCTTTAAACTTGTTATGGAGATAGTTTAATGTAAAACCAACTACGGAAAACCCTCAACT
TAAGGATACAGCTTGGAAATTGGAACTGCAATTGCCTTTTATTAAAACCATATGGTGTGATGTTTGTTTTTAAAATTATATAAGACTTTA
TGCTGTCACTTCTCTTGCTGTACTGTAATTCATGTTTTAAATGAATTTGATAATGAAATTATACTATTATCATTCTTGATGAATACTTTT
CTTATTTTTATGATTTTTCTAATGAAACTTTAAACTTTTGAGATTTGAGAGTCTGTTTTCTATAAGTAGAATTACTGTTGTTACAAAATG
AAAAAGGACTGACCTAAAATCAGTCTCTTCTTTTGGTCTGTGATGGATTTTAATGGCCGTTCTGTGCTCATATATACCTAAGATGAGATT
ATATTACATCCACCAAAGACTCAGTTTGAAGATAAGGAATGAGTGATAGAAGAAATAAGGCTGAGATCCTTAAAAGCCTAATTAATTTAA
CTCGCTTAACCCATTAGTACTATCTAGTACAAGACCCCTTTTTTTTTGCTGAAATTATGGTATATTTTCAACTTCACTAATTACAAATTA
TCTAGATTTAGAACTCTATATGTCAGCATTGACCTGGGAATGAAGTCAGGATAGAGAAATTCCACTTGCCTGTGATGGGTCCTTAGAAGT
ATCAGCTAAGGAGTGACCCTGTCCTATACACAGGGCTCTCTATTACGTTCCATACCCTGGGCCTACCCAAGGTGACATTCCTGCTGTTTA
CATGGCATAGGCACCTGTGAGATCAGTGTCACAATTTCATCTTAGAAAGAGGTAGGTATGGCTGCTTTGTCGGTTGAAAGTTAAGGGGAG
CCATGATCTACCATATTTAGGAAAAAGTTATTTAAAAAAGAGCAGATGGTGGAAAAAGAATGTAAGACCCAGAATTTATCCCTTTGACAA
TGAATCTGGCCTTTTTAATAGCAGGATGGAATTGATTCACTAGTTTTTGCTAACTTTCACTTTCAGTAAAGGTTGAGGTGTTGTTTTTGC
AATGACTGTGTATTCATTGAGGAAAGGTTTCCAATGAAATTTCATTACTCTGACCTCTTCTAATTTTTGGTCTTCTTTATATTTACATGT
CTTACATTCCACAAAATTATTTAGAAATGCTGGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTTGTGAGGCCGATGTGGGTGGATCA
CTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAATATGGAGAAATCCCATCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGCATG
TGCACGCCTGTAATCCCCGCTACTCGGGAGGCTGTGGCAGGAGAATTGCCTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTG
CCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAATTGTATAGAAATAAATTTTTAGTTGCTTTAT
GCACTAATTCCTTACTGGGGATAGAAGCTAATTATTGTGAAATAACCTAGTTTAGAAGTTAGAAGATCAGCATGTCTGAGTTTTTACAGA
ATTATAATTCATGGTATTCCAAACCAACTGTTGTTATTTATTTCCAGTGAGAACCATTTTCCCACTGACCTTCCTCCTTTCAGAGGATGG
GGATTAGGAGGCCCAAAGTACTGATTGAGTAGGAATACTTTTTTACTCTTCTTCACTGTGGAGAAAGAAGAGGGCAGGTAGTTGATGATG
TCAGGAGAACAGATTTTATGGTGTGGAATACCATACCTAAACACAAATGAATCAGATTAGACCACAGAATTGTGATGATGGCAGTCAGAA
TGTAATACGGTCATCATGAAACAGCACAGTGTGAGAGGTCAAGGTGTCAACCTGGGAAGTGAGAATCAAGCAGGAGTGTGGCATGGCAAC
CAACTCACAGATCCAGAGTTGAGAGGGATCACTACTGCAGCAGTTCTGCTCTGTTACTCTGGTAAGTAGTAGAGCCACTTTATGAGCCCT
TATTTCCTATCTCCCTTATTCTGAGGCCAGGTCAGTGATATGCTATAGTTTCATTTAAGTTAATGGAGTATAAAGATGGGATACTTGGGA
GCTATATTGTGCATCAGGGTGTCACAGCTGCTACTAGGAGTTACTCCTTTTCATGTCTTTTAAAATACTTTCTACCCATCTTAATTGCTA
AATTATCTTTCAGTTAGTTACAGCGCTTAATTTAAAACCTGTACTGTTTTCATCCTGAATTTAGAACATAAGATTTAGCCTTTGAAGTAT
AGTTTCAGACTTTACTAATTTGTTTAATATAATCCTTATTAACATGACAAAATGAAAGCCCTGTTGGGACTTAGTCTAAACAGTAGTCTT
TGATCTGAAAGTGTCTCATATTTTGTGATCTATTAGAAACATAAACCTTTGCTTATGCAGAAGGTCTTTCTTAGAACAATCCTGTAATCT
TAGGGTTCATGTGTGACTAGCATTATCCTCTCTTTGATGTTGGGTAATAGAGGCTGAACTTTTCTTGTGTATATATAGTTAGTTTTGAGG
CCATAAATCTAGGACTTCTCAAAAGATTAGAACATTTATCCAGTAAACTGACTCCATTGAAGACTTCATTTCTGGAAATACCACATTGCT
TCTGCTCTCAATAACTCTATCATTTACTCGTATAAATATTGCTAGCTGTAATGCACAGAGAAAAACTACCTCATTCAATCTAGATAATTG
GGACATCCTTTTCCAGTAAACCCTTTTTCCACTACTGGATAAAATATTAAAATGATCAGTTTGAGTGTATGTTAGAGTTCATGTTTCTGT
AACTAAAGGTGCTAATAAACTGAAATCAGATAAGGTAGGTTTTTCCAAAAATACTTCTAAATAATTGACAACCTAGAAGTCAACAATGTA
AAATGCATATGGGACTCTATATTAATAGAGAAGCAGGCCAAGAACTTTTTAATGGGATAATTGTCTTCTTTAGGCACATTGTTTGCATAT
TAACGACATGGAAATATTTTCACTCATTTACTTTCATCCATCTATCTGTGCTTTTTCTCACTTTGATGAGTTCTCTCAACTCCTTTCTAA
GAAAAGCAGAGCAGAGCAGCATAGAGTGCGTTAGTAAATGGCCACTGACTCTTGGTCTCAGGCCATAGCAACTATAGAGAGAAGAGTGGG
GCTGGAGACCTCATACCCTGGGTAAAGTGGACATCACTTGTCAGCTCCAGCTAATTGTCACCACAGAGAGAAGAGGGTAAGTCTGAGATG
TTCATGTGCATTTCCCTACATTTTAGAGGTTGACAAAATAGTTTGTGACTTTTGCTTACATTTGCATTCATAGAACTAAAAAAAATTTAA
CTTGGCTAACAAAATACCACATGCATATTTTCTTTTTTATTTTTATTTTTTGAGACAGAGTCTCTGTTACCCAGGCTGGGGGGCAGTGAT
AAGATCTTGGCTCACTGCAACCTCCGCCTCCAGGGTTGAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCAC
CACCACACCCAGCTAATTTTAGTATTCTTAGTAGAGACAGGATTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAACTGAT
CCACCCACCCTGGCCTCCCAAAGTGTCAGGATTACAGGCGTGAGCCTCTGCAACTGGCCAACATGCATATTTAAATTATGCATGCATTGT
AGCTGTATACTGTGTGACCACATTTACTTAAAAAAGAGGAAAAAAGGTTACTTGCTTGAGACAGGAAACTATCACCTTTGAAAGCATATT
AAGTAGTTGGCTTACTTTGGAACACACAGTAGACTGAAAATGTGAACTAATACTTTAAAATTGCCGTATAATGATGTCATTGCAAGCCAT
TCATCTATCCAATGGGGGAAAATGTGGAGGTCTAGGCTTGTGTTGTCACAAAATACACCTTTTAGATAATCCTTACCTGTACAGATTTTT
ATAACTGTTGTTATCATAAGAGAATGGCTACATCATTATCCTGCCTTTTCTGGGTGTTTATTTTGTTGTTTTTGAAAGTGGACAAAACCT
CAAAGCACAATTTTGTTCTGATATATCCAGTTTAGTAGTTTATGCTGGTTAAATGATCAAAGTAATTGCTTAAATGTCTTGTGGAATTAG

>4759_4759_1_ANKRD50-METTL14_ANKRD50_chr4_125631154_ENST00000504087_METTL14_chr4_119609077_ENST00000388822_length(amino acids)=434AA_BP=1
MGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQS
LNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRET
GITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGI
KGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPN

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Fusion Gene PPI Analysis for ANKRD50-METTL14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	METTL14	chr4:125631154	chr4:119609077	ENST00000388822		0	11	135_136	22.0	457.0	METTL3
Tgene	METTL14	chr4:125631154	chr4:119609077	ENST00000388822		0	11	237_238	22.0	457.0	METTL3
Tgene	METTL14	chr4:125631154	chr4:119609077	ENST00000388822		0	11	255_258	22.0	457.0	METTL3
Tgene	METTL14	chr4:125631154	chr4:119609077	ENST00000388822		0	11	278_287	22.0	457.0	METTL3
Tgene	METTL14	chr4:125631154	chr4:119609077	ENST00000388822		0	11	308_312	22.0	457.0	METTL3

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ANKRD50-METTL14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ANKRD50-METTL14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Fusion Gene Studies in Kim Lab

Fusion gene:ANKRD50-METTL14 (FusionGDB2 ID:HG57182TG57721)

Fusion Gene Summary for ANKRD50-METTL14

Fusion Gene ORF analysis for ANKRD50-METTL14

Fusion Genomic Features for ANKRD50-METTL14

Fusion Protein Features for ANKRD50-METTL14

Fusion Gene Sequence for ANKRD50-METTL14

Fusion Gene PPI Analysis for ANKRD50-METTL14

Related Drugs for ANKRD50-METTL14

Related Diseases for ANKRD50-METTL14

Fusion Gene Studies
in Kim Lab