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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP10D-GABRA2 (FusionGDB2 ID:HG57205TG2555)

Fusion Gene Summary for ATP10D-GABRA2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP10D-GABRA2
Fusion gene ID: hg57205tg2555
HgeneTgene
Gene symbol

ATP10D

GABRA2

Gene ID

57205

2555

Gene nameATPase phospholipid transporting 10D (putative)gamma-aminobutyric acid type A receptor subunit alpha2
SynonymsATPVDEIEE78
Cytomap('ATP10D')('GABRA2')

4p12

4p12

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase VDATPase, class V, type 10DP4-ATPase flippase complex alpha subunit ATP10Dtype IV aminophospholipid transporting ATPasegamma-aminobutyric acid receptor subunit alpha-2GABA(A) receptor subunit alpha-2gamma-aminobutyric acid type A receptor alpha2 subunit
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000273859, ENST00000504445, 
ENST00000512393, 
Fusion gene scores* DoF score6 X 6 X 6=2162 X 2 X 2=8
# samples 62
** MAII scorelog2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ATP10D [Title/Abstract] AND GABRA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP10D(47527659)-GABRA2(46252621), # samples:4
Anticipated loss of major functional domain due to fusion event.ATP10D-GABRA2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ATP10D-GABRA2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ATP10D-GABRA2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGABRA2

GO:1902476

chloride transmembrane transport

9039914


check buttonFusion gene breakpoints across ATP10D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GABRA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-O2-A52V-01AATP10Dchr4

47527659

-GABRA2chr4

46252621

-
ChimerDB4LUSCTCGA-O2-A52V-01AATP10Dchr4

47527659

+GABRA2chr4

46252621

-
ChimerDB4LUSCTCGA-O2-A52VATP10Dchr4

47527659

+GABRA2chr4

46252621

-


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Fusion Gene ORF analysis for ATP10D-GABRA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000273859ENST00000507460ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
5CDS-intronENST00000273859ENST00000509716ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
5CDS-intronENST00000273859ENST00000515082ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
5CDS-intronENST00000504445ENST00000507460ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
5CDS-intronENST00000504445ENST00000509716ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
5CDS-intronENST00000504445ENST00000515082ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
Frame-shiftENST00000273859ENST00000514090ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
Frame-shiftENST00000273859ENST00000540012ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
Frame-shiftENST00000504445ENST00000514090ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
Frame-shiftENST00000504445ENST00000540012ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
In-frameENST00000273859ENST00000356504ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
In-frameENST00000273859ENST00000381620ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
In-frameENST00000273859ENST00000507069ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
In-frameENST00000273859ENST00000510861ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
In-frameENST00000504445ENST00000356504ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
In-frameENST00000504445ENST00000381620ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
In-frameENST00000504445ENST00000507069ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
In-frameENST00000504445ENST00000510861ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
intron-3CDSENST00000512393ENST00000356504ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
intron-3CDSENST00000512393ENST00000381620ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
intron-3CDSENST00000512393ENST00000507069ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
intron-3CDSENST00000512393ENST00000510861ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
intron-3CDSENST00000512393ENST00000514090ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
intron-3CDSENST00000512393ENST00000540012ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
intron-intronENST00000512393ENST00000507460ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
intron-intronENST00000512393ENST00000509716ATP10Dchr4

47527659

+GABRA2chr4

46252621

-
intron-intronENST00000512393ENST00000515082ATP10Dchr4

47527659

+GABRA2chr4

46252621

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273859ATP10Dchr447527659+ENST00000510861GABRA2chr446252621-322310452631069268
ENST00000273859ATP10Dchr447527659+ENST00000381620GABRA2chr446252621-230710452631069268
ENST00000273859ATP10Dchr447527659+ENST00000356504GABRA2chr446252621-208310452631069268
ENST00000273859ATP10Dchr447527659+ENST00000507069GABRA2chr446252621-136110452631069268
ENST00000504445ATP10Dchr447527659+ENST00000510861GABRA2chr446252621-321210342521058268
ENST00000504445ATP10Dchr447527659+ENST00000381620GABRA2chr446252621-229610342521058268
ENST00000504445ATP10Dchr447527659+ENST00000356504GABRA2chr446252621-207210342521058268
ENST00000504445ATP10Dchr447527659+ENST00000507069GABRA2chr446252621-135010342521058268

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273859ENST00000510861ATP10Dchr447527659+GABRA2chr446252621-0.0007359670.99926406
ENST00000273859ENST00000381620ATP10Dchr447527659+GABRA2chr446252621-0.0010230160.99897707
ENST00000273859ENST00000356504ATP10Dchr447527659+GABRA2chr446252621-0.0011152260.99888474
ENST00000273859ENST00000507069ATP10Dchr447527659+GABRA2chr446252621-0.0015060790.9984939
ENST00000504445ENST00000510861ATP10Dchr447527659+GABRA2chr446252621-0.0007489690.99925095
ENST00000504445ENST00000381620ATP10Dchr447527659+GABRA2chr446252621-0.0009871930.9990128
ENST00000504445ENST00000356504ATP10Dchr447527659+GABRA2chr446252621-0.0010981560.99890184
ENST00000504445ENST00000507069ATP10Dchr447527659+GABRA2chr446252621-0.0015882980.99841166

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Fusion Genomic Features for ATP10D-GABRA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATP10D-GABRA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:47527659/chr4:46252621)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+523119_1212581427.0Topological domainExoplasmic loop
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231_972581427.0Topological domainCytoplasmic
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+523122_1422581427.0TransmembraneHelical
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+52398_1182581427.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST0000035650479420_441353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000381620810420_441353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000510861810420_441353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000514090810420_441353452.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231364_13712581427.0Nucleotide bindingATP
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+523996_10032581427.0Nucleotide bindingATP
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231135_11452581427.0Topological domainExoplasmic loop
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231167_11952581427.0Topological domainCytoplasmic
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231217_12242581427.0Topological domainExoplasmic loop
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231246_12522581427.0Topological domainCytoplasmic
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231274_12922581427.0Topological domainExoplasmic loop
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231314_14262581427.0Topological domainCytoplasmic
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+523143_3212581427.0Topological domainCytoplasmic
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+523343_3652581427.0Topological domainExoplasmic loop
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+523387_11132581427.0Topological domainCytoplasmic
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231114_11342581427.0TransmembraneHelical
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231146_11662581427.0TransmembraneHelical
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231196_12162581427.0TransmembraneHelical
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231225_12452581427.0TransmembraneHelical
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231253_12732581427.0TransmembraneHelical
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+5231293_13132581427.0TransmembraneHelical
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+523322_3422581427.0TransmembraneHelical
HgeneATP10Dchr4:47527659chr4:46252621ENST00000273859+523366_3862581427.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST000003565047929_251353452.0Topological domainExtracellular
TgeneGABRA2chr4:47527659chr4:46252621ENST0000035650479335_419353452.0Topological domainCytoplasmic
TgeneGABRA2chr4:47527659chr4:46252621ENST0000038162081029_251353452.0Topological domainExtracellular
TgeneGABRA2chr4:47527659chr4:46252621ENST00000381620810335_419353452.0Topological domainCytoplasmic
TgeneGABRA2chr4:47527659chr4:46252621ENST0000051086181029_251353452.0Topological domainExtracellular
TgeneGABRA2chr4:47527659chr4:46252621ENST00000510861810335_419353452.0Topological domainCytoplasmic
TgeneGABRA2chr4:47527659chr4:46252621ENST0000051409081029_251353452.0Topological domainExtracellular
TgeneGABRA2chr4:47527659chr4:46252621ENST00000514090810335_419353452.0Topological domainCytoplasmic
TgeneGABRA2chr4:47527659chr4:46252621ENST0000035650479252_273353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST0000035650479279_300353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST0000035650479313_334353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000381620810252_273353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000381620810279_300353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000381620810313_334353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000510861810252_273353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000510861810279_300353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000510861810313_334353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000514090810252_273353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000514090810279_300353452.0TransmembraneHelical
TgeneGABRA2chr4:47527659chr4:46252621ENST00000514090810313_334353452.0TransmembraneHelical


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Fusion Gene Sequence for ATP10D-GABRA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7697_7697_1_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000273859_GABRA2_chr4_46252621_ENST00000356504_length(transcript)=2083nt_BP=1045nt
GACGGGAGGAGGAGCGGAGGGAGAAGTAGGTTGCGAGCTCAGCACAGGCTCCGGCGCTGGCTCCCGCAGCTGAGTTTGGGAGATGTCTAA
GTGATTTTTTTTTTTTCCCGGAAGGCAAATGGCTGGCGTGGAAGCACAACCCGCTTTCACTCTTCGAATTTGTGCTTAGCTCTTTTCTTG
TACCTTGCGACTCGTGACCAACATGCTGTGATGTGTGCCGAGGGAGGAATTGGTCAGCTACACAACCTGGATCTTACCACAGTTTGGATA
TGACTGAGGCTCTCCAATGGGCCAGATATCACTGGCGACGGCTGATCAGAGGTGCAACCAGGGATGATGATTCAGGGCCATACAACTATT
CCTCGTTGCTCGCCTGTGGGCGCAAGTCCTCTCAGACCCCTAAACTGTCAGGAAGGCACCGGATTGTTGTTCCCCACATCCAGCCCTTCA
AGGATGAGTATGAGAAGTTCTCCGGAGCCTATGTGAACAATCGAATACGAACAACAAAGTACACACTTCTGAATTTTGTGCCAAGAAATT
TATTTGAACAATTTCACAGAGCTGCCAATTTATATTTCCTGTTCCTAGTTGTCCTGAACTGGGTACCTTTGGTAGAAGCCTTCCAAAAGG
AAATCACCATGTTGCCTCTGGTGGTGGTCCTTACAATTATCGCAATTAAAGATGGCCTGGAAGATTATCGGAAATACAAAATTGACAAAC
AGATCAATAATTTAATAACTAAAGTTTATAGTAGGAAAGAGAAAAAATACATTGACCGATGCTGGAAAGACGTTACTGTTGGGGACTTTA
TTCGCCTCTCCTGCAACGAGGTCATCCCTGCAGACATGGTACTACTCTTTTCCACTGATCCAGATGGAATCTGTCACATTGAGACTTCTG
GTCTTGATGGAGAGAGCAATTTAAAACAGAGGCAGGTGGTTCGGGGATATGCAGAACAGGACTCTGAAGTTGATCCTGAGAAGTTTTCCA
GTAGGATAGAATGTGAAAGCCCAAACAATGACCTCAGCAGATTCCGAGGCTTCCTAAAAAAGAAAAGGCTTCCGTTATGATACAGAACAA
CGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAAGATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGA
ACCCAACAAGAAGCCAGAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATGTCCAGAATAGTTTT
TCCAGTTTTGTTTGGTACCTTTAATTTAGTTTACTGGGCTACATATTTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGAATTGAGAC
CCATGTTATCTTTGGGATGTATAGCAACATTAAATTTGGTTTGTTTTGCTATGTACAGTCTGACTAATAACTGCTAATTTGTGATCCAAC
ATGTACAGTATGTATATAGTGACATAGCTTACCAGTAGACCTTTAATGGAGACATGCATTTGCTAACTCATGGAACTGCAGACAGAAAGC
ACTCCATGCGAAAACAGCCATTGCCTTTTTTAAAGATTTACCCTAGGACCTGATTTAAAGTGAATTTCAAGTGACCTGATTAATTTCCTA
TTCTTCCAAATGAGATGAAAATGGGGATCCTGTACAACCCTTTGTGGACCCTTTTGGTTTAGCTCTTAAGTAGGGGTATTTTCTACTGTT
GCTTAATTATGATGGAAGATAACATTGTCATTCCTAGATGAATCCTTTGAAGTAACAAACATTGTATCTGACATCAGCTCTGTTCATGAG
TGCTCAGAGTCCCTGCTAATGTAATTGGAAGCTTGGTACACATAAGAAAAACTAGAGATTTGAAATCAGCTATGAATTACTCTATATAGT
ATCTATAGCCATGTACATATTACAGCATGACAAGCTCAAATAATTATGAGTCAGCCCGAAAGGATGTTAATTATGCCTACGATGTAATAA
CTATTGGAATGTCATGGTCATTACATTTTTAGCTTCAGAGTTTATTTGAAAGTAATAATTGAAATCCTACAATTTATTTTAATCATTGGA
AACTACCTTAATT

>7697_7697_1_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000273859_GABRA2_chr4_46252621_ENST00000356504_length(amino acids)=268AA_BP=
MDMTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVP
RNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVG
DFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLKKKRLPL

--------------------------------------------------------------
>7697_7697_2_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000273859_GABRA2_chr4_46252621_ENST00000381620_length(transcript)=2307nt_BP=1045nt
GACGGGAGGAGGAGCGGAGGGAGAAGTAGGTTGCGAGCTCAGCACAGGCTCCGGCGCTGGCTCCCGCAGCTGAGTTTGGGAGATGTCTAA
GTGATTTTTTTTTTTTCCCGGAAGGCAAATGGCTGGCGTGGAAGCACAACCCGCTTTCACTCTTCGAATTTGTGCTTAGCTCTTTTCTTG
TACCTTGCGACTCGTGACCAACATGCTGTGATGTGTGCCGAGGGAGGAATTGGTCAGCTACACAACCTGGATCTTACCACAGTTTGGATA
TGACTGAGGCTCTCCAATGGGCCAGATATCACTGGCGACGGCTGATCAGAGGTGCAACCAGGGATGATGATTCAGGGCCATACAACTATT
CCTCGTTGCTCGCCTGTGGGCGCAAGTCCTCTCAGACCCCTAAACTGTCAGGAAGGCACCGGATTGTTGTTCCCCACATCCAGCCCTTCA
AGGATGAGTATGAGAAGTTCTCCGGAGCCTATGTGAACAATCGAATACGAACAACAAAGTACACACTTCTGAATTTTGTGCCAAGAAATT
TATTTGAACAATTTCACAGAGCTGCCAATTTATATTTCCTGTTCCTAGTTGTCCTGAACTGGGTACCTTTGGTAGAAGCCTTCCAAAAGG
AAATCACCATGTTGCCTCTGGTGGTGGTCCTTACAATTATCGCAATTAAAGATGGCCTGGAAGATTATCGGAAATACAAAATTGACAAAC
AGATCAATAATTTAATAACTAAAGTTTATAGTAGGAAAGAGAAAAAATACATTGACCGATGCTGGAAAGACGTTACTGTTGGGGACTTTA
TTCGCCTCTCCTGCAACGAGGTCATCCCTGCAGACATGGTACTACTCTTTTCCACTGATCCAGATGGAATCTGTCACATTGAGACTTCTG
GTCTTGATGGAGAGAGCAATTTAAAACAGAGGCAGGTGGTTCGGGGATATGCAGAACAGGACTCTGAAGTTGATCCTGAGAAGTTTTCCA
GTAGGATAGAATGTGAAAGCCCAAACAATGACCTCAGCAGATTCCGAGGCTTCCTAAAAAAGAAAAGGCTTCCGTTATGATACAGAACAA
CGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAAGATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGA
ACCCAACAAGAAGCCAGAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATGTCCAGAATAGTTTT
TCCAGTTTTGTTTGGTACCTTTAATTTAGTTTACTGGGCTACATATTTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGAATTGAGAC
CCATGTTATCTTTGGGATGTATAGCAACATTAAATTTGGTTTGTTTTGCTATGTACAGTCTGACTAATAACTGCTAATTTGTGATCCAAC
ATGTACAGTATGTATATAGTGACATAGCTTACCAGTAGACCTTTAATGGAGACATGCATTTGCTAACTCATGGAACTGCAGACAGAAAGC
ACTCCATGCGAAAACAGCCATTGCCTTTTTTAAAGATTTACCCTAGGACCTGATTTAAAGTGAATTTCAAGTGACCTGATTAATTTCCTA
TTCTTCCAAATGAGATGAAAATGGGGATCCTGTACAACCCTTTGTGGACCCTTTTGGTTTAGCTCTTAAGTAGGGGTATTTTCTACTGTT
GCTTAATTATGATGGAAGATAACATTGTCATTCCTAGATGAATCCTTTGAAGTAACAAACATTGTATCTGACATCAGCTCTGTTCATGAG
TGCTCAGAGTCCCTGCTAATGTAATTGGAAGCTTGGTACACATAAGAAAAACTAGAGATTTGAAATCAGCTATGAATTACTCTATATAGT
ATCTATAGCCATGTACATATTACAGCATGACAAGCTCAAATAATTATGAGTCAGCCCGAAAGGATGTTAATTATGCCTACGATGTAATAA
CTATTGGAATGTCATGGTCATTACATTTTTAGCTTCAGAGTTTATTTGAAAGTAATAATTGAAATCCTACAATTTATTTTAATCATTGGA
AACTACCTTAATTAAAAAAAAAGAAAAGAAATGTGTCTTAACATTTCCAGGTATGTGTTGTATTGAAATTGATCAGCTAAATTTTACGGG
TGCTGGAGACTGGAAAAAGCATCCAGTTTGGTTGCTGTGGAGCAACATGCATATTGGATTAGAAAATTGTGCCAAAAACTCCCACTGATG
AGAATTCATAGGTGCCCCACACTATGACAAACACTTATATGATTCTCCTCTTTCCTG

>7697_7697_2_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000273859_GABRA2_chr4_46252621_ENST00000381620_length(amino acids)=268AA_BP=
MDMTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVP
RNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVG
DFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLKKKRLPL

--------------------------------------------------------------
>7697_7697_3_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000273859_GABRA2_chr4_46252621_ENST00000507069_length(transcript)=1361nt_BP=1045nt
GACGGGAGGAGGAGCGGAGGGAGAAGTAGGTTGCGAGCTCAGCACAGGCTCCGGCGCTGGCTCCCGCAGCTGAGTTTGGGAGATGTCTAA
GTGATTTTTTTTTTTTCCCGGAAGGCAAATGGCTGGCGTGGAAGCACAACCCGCTTTCACTCTTCGAATTTGTGCTTAGCTCTTTTCTTG
TACCTTGCGACTCGTGACCAACATGCTGTGATGTGTGCCGAGGGAGGAATTGGTCAGCTACACAACCTGGATCTTACCACAGTTTGGATA
TGACTGAGGCTCTCCAATGGGCCAGATATCACTGGCGACGGCTGATCAGAGGTGCAACCAGGGATGATGATTCAGGGCCATACAACTATT
CCTCGTTGCTCGCCTGTGGGCGCAAGTCCTCTCAGACCCCTAAACTGTCAGGAAGGCACCGGATTGTTGTTCCCCACATCCAGCCCTTCA
AGGATGAGTATGAGAAGTTCTCCGGAGCCTATGTGAACAATCGAATACGAACAACAAAGTACACACTTCTGAATTTTGTGCCAAGAAATT
TATTTGAACAATTTCACAGAGCTGCCAATTTATATTTCCTGTTCCTAGTTGTCCTGAACTGGGTACCTTTGGTAGAAGCCTTCCAAAAGG
AAATCACCATGTTGCCTCTGGTGGTGGTCCTTACAATTATCGCAATTAAAGATGGCCTGGAAGATTATCGGAAATACAAAATTGACAAAC
AGATCAATAATTTAATAACTAAAGTTTATAGTAGGAAAGAGAAAAAATACATTGACCGATGCTGGAAAGACGTTACTGTTGGGGACTTTA
TTCGCCTCTCCTGCAACGAGGTCATCCCTGCAGACATGGTACTACTCTTTTCCACTGATCCAGATGGAATCTGTCACATTGAGACTTCTG
GTCTTGATGGAGAGAGCAATTTAAAACAGAGGCAGGTGGTTCGGGGATATGCAGAACAGGACTCTGAAGTTGATCCTGAGAAGTTTTCCA
GTAGGATAGAATGTGAAAGCCCAAACAATGACCTCAGCAGATTCCGAGGCTTCCTAAAAAAGAAAAGGCTTCCGTTATGATACAGAACAA
CGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAAGATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGA
ACCCAACAAGAAGCCAGAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATGTCCAGAATAGTTTT
TCCAGTTTTGTTTGGTACCTTTAATTTAGTTTACTGGGCTACATATTTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGAATTGAGAC
CCATGTTATCT

>7697_7697_3_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000273859_GABRA2_chr4_46252621_ENST00000507069_length(amino acids)=268AA_BP=
MDMTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVP
RNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVG
DFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLKKKRLPL

--------------------------------------------------------------
>7697_7697_4_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000273859_GABRA2_chr4_46252621_ENST00000510861_length(transcript)=3223nt_BP=1045nt
GACGGGAGGAGGAGCGGAGGGAGAAGTAGGTTGCGAGCTCAGCACAGGCTCCGGCGCTGGCTCCCGCAGCTGAGTTTGGGAGATGTCTAA
GTGATTTTTTTTTTTTCCCGGAAGGCAAATGGCTGGCGTGGAAGCACAACCCGCTTTCACTCTTCGAATTTGTGCTTAGCTCTTTTCTTG
TACCTTGCGACTCGTGACCAACATGCTGTGATGTGTGCCGAGGGAGGAATTGGTCAGCTACACAACCTGGATCTTACCACAGTTTGGATA
TGACTGAGGCTCTCCAATGGGCCAGATATCACTGGCGACGGCTGATCAGAGGTGCAACCAGGGATGATGATTCAGGGCCATACAACTATT
CCTCGTTGCTCGCCTGTGGGCGCAAGTCCTCTCAGACCCCTAAACTGTCAGGAAGGCACCGGATTGTTGTTCCCCACATCCAGCCCTTCA
AGGATGAGTATGAGAAGTTCTCCGGAGCCTATGTGAACAATCGAATACGAACAACAAAGTACACACTTCTGAATTTTGTGCCAAGAAATT
TATTTGAACAATTTCACAGAGCTGCCAATTTATATTTCCTGTTCCTAGTTGTCCTGAACTGGGTACCTTTGGTAGAAGCCTTCCAAAAGG
AAATCACCATGTTGCCTCTGGTGGTGGTCCTTACAATTATCGCAATTAAAGATGGCCTGGAAGATTATCGGAAATACAAAATTGACAAAC
AGATCAATAATTTAATAACTAAAGTTTATAGTAGGAAAGAGAAAAAATACATTGACCGATGCTGGAAAGACGTTACTGTTGGGGACTTTA
TTCGCCTCTCCTGCAACGAGGTCATCCCTGCAGACATGGTACTACTCTTTTCCACTGATCCAGATGGAATCTGTCACATTGAGACTTCTG
GTCTTGATGGAGAGAGCAATTTAAAACAGAGGCAGGTGGTTCGGGGATATGCAGAACAGGACTCTGAAGTTGATCCTGAGAAGTTTTCCA
GTAGGATAGAATGTGAAAGCCCAAACAATGACCTCAGCAGATTCCGAGGCTTCCTAAAAAAGAAAAGGCTTCCGTTATGATACAGAACAA
CGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAAGATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGA
ACCCAACAAGAAGCCAGAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATGTCCAGAATAGTTTT
TCCAGTTTTGTTTGGTACCTTTAATTTAGTTTACTGGGCTACATATTTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGAATTGAGAC
CCATGTTATCTTTGGGATGTATAGCAACATTAAATTTGGTTTGTTTTGCTATGTACAGTCTGACTAATAACTGCTAATTTGTGATCCAAC
ATGTACAGTATGTATATAGTGACATAGCTTACCAGTAGACCTTTAATGGAGACATGCATTTGCTAACTCATGGAACTGCAGACAGAAAGC
ACTCCATGCGAAAACAGCCATTGCCTTTTTTAAAGATTTACCCTAGGACCTGATTTAAAGTGAATTTCAAGTGACCTGATTAATTTCCTA
TTCTTCCAAATGAGATGAAAATGGGGATCCTGTACAACCCTTTGTGGACCCTTTTGGTTTAGCTCTTAAGTAGGGGTATTTTCTACTGTT
GCTTAATTATGATGGAAGATAACATTGTCATTCCTAGATGAATCCTTTGAAGTAACAAACATTGTATCTGACATCAGCTCTGTTCATGAG
TGCTCAGAGTCCCTGCTAATGTAATTGGAAGCTTGGTACACATAAGAAAAACTAGAGATTTGAAATCAGCTATGAATTACTCTATATAGT
ATCTATAGCCATGTACATATTACAGCATGACAAGCTCAAATAATTATGAGTCAGCCCGAAAGGATGTTAATTATGCCTACGATGTAATAA
CTATTGGAATGTCATGGTCATTACATTTTTAGCTTCAGAGTTTATTTGAAAGTAATAATTGAAATCCTACAATTTATTTTAATCATTGGA
AACTACCTTAATTAAAAAAAAAGAAAAGAAATGTGTCTTAACATTTCCAGGTATGTGTTGTATTGAAATTGATCAGCTAAATTTTACGGG
TGCTGGAGACTGGAAAAAGCATCCAGTTTGGTTGCTGTGGAGCAACATGCATATTGGATTAGAAAATTGTGCCAAAAACTCCCACTGATG
AGAATTCATAGGTGCCCCACACTATGACAAACACTTATATGATTCTCCTCTTTCCTGTTTACTGCAAATTCTGCCTTAAGGCTTCTTTTC
AAGACTCAGAAGCCACTAATTATAAAGGAAAGGGCAGTTAATTGGCACATTTTTCTCTTGTGAAAGCAGTTCTTTCAGATAAGAATTAAT
GTAAATCTGCTTTTGTAAATTGCAACTTTAAATTTCGCTGACTCAAATTTACAACAGCTTTGTATACCAGAAGAGGTTTTGGTAAGGGTT
GAACATTTTTACACTGCAACTTTAAAACATCACCAATAGATTGTGGATTATTTCACGTGCACAAACATACACACACACACACACACACAC
ACACATACACAGCTAAATTAGAAAACACAATTTTAAATTTTATATAATTACTAGTTATTAATGGGTAAAATTCATTTTTCTTTTAATATC
TTAAAATATTATTTATGCCCCGAAATATGCTAATAAAAGTTAAAGATTGTGTATTATGCCTAGATTCAAAGTTTTTGGCAAACTTCAAAT
ACTTTTGATTGACATGTACATTAGCAGTTATTAGTTGACTTTTACTAAAACATGCACCTTTACGATGGTGTTTTTGTAGAAACATAAGTA
GTCAAATAGTAACATTTATTGCAGTTTTGTACAGTATTTGAGTATAGTGCATAAATAGGTATGTTCATAAAATCAATAAAAGGAGTATCT
ATGGAAATAAGCAAAATATCAGCAAAAATTGCTATTCCTTTGCCTCATTTAATTTTTAAAATTTCTTTGTTTCCATGTGATTCTATTATA
TGCTTTGCATGCTTGTATAAAACCAAGGTCACAAATGCAACTTATTAACGGAATTTGCCAAGAAGACAGCCTTGACATTAAAAATTCCCT
CACAAGAGGTAATCCATAATCCTTAATAAAATAAAATTGTTACATGAGCCAATAAATGTATTTCTTTAATTCC

>7697_7697_4_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000273859_GABRA2_chr4_46252621_ENST00000510861_length(amino acids)=268AA_BP=
MDMTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVP
RNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVG
DFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLKKKRLPL

--------------------------------------------------------------
>7697_7697_5_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000504445_GABRA2_chr4_46252621_ENST00000356504_length(transcript)=2072nt_BP=1034nt
GAGCGGAGGGAGAAGTAGGTTGCGAGCTCAGCACAGGCTCCGGCGCTGGCTCCCGCAGCTGAGTTTGGGAGATGTCTAAGTGATTTTTTT
TTTTTCCCGGAAGGCAAATGGCTGGCGTGGAAGCACAACCCGCTTTCACTCTTCGAATTTGTGCTTAGCTCTTTTCTTGTACCTTGCGAC
TCGTGACCAACATGCTGTGATGTGTGCCGAGGGAGGAATTGGTCAGCTACACAACCTGGATCTTACCACAGTTTGGATATGACTGAGGCT
CTCCAATGGGCCAGATATCACTGGCGACGGCTGATCAGAGGTGCAACCAGGGATGATGATTCAGGGCCATACAACTATTCCTCGTTGCTC
GCCTGTGGGCGCAAGTCCTCTCAGACCCCTAAACTGTCAGGAAGGCACCGGATTGTTGTTCCCCACATCCAGCCCTTCAAGGATGAGTAT
GAGAAGTTCTCCGGAGCCTATGTGAACAATCGAATACGAACAACAAAGTACACACTTCTGAATTTTGTGCCAAGAAATTTATTTGAACAA
TTTCACAGAGCTGCCAATTTATATTTCCTGTTCCTAGTTGTCCTGAACTGGGTACCTTTGGTAGAAGCCTTCCAAAAGGAAATCACCATG
TTGCCTCTGGTGGTGGTCCTTACAATTATCGCAATTAAAGATGGCCTGGAAGATTATCGGAAATACAAAATTGACAAACAGATCAATAAT
TTAATAACTAAAGTTTATAGTAGGAAAGAGAAAAAATACATTGACCGATGCTGGAAAGACGTTACTGTTGGGGACTTTATTCGCCTCTCC
TGCAACGAGGTCATCCCTGCAGACATGGTACTACTCTTTTCCACTGATCCAGATGGAATCTGTCACATTGAGACTTCTGGTCTTGATGGA
GAGAGCAATTTAAAACAGAGGCAGGTGGTTCGGGGATATGCAGAACAGGACTCTGAAGTTGATCCTGAGAAGTTTTCCAGTAGGATAGAA
TGTGAAAGCCCAAACAATGACCTCAGCAGATTCCGAGGCTTCCTAAAAAAGAAAAGGCTTCCGTTATGATACAGAACAACGCTTATGCAG
TGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAAGATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGAACCCAACAAGA
AGCCAGAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATGTCCAGAATAGTTTTTCCAGTTTTGT
TTGGTACCTTTAATTTAGTTTACTGGGCTACATATTTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGAATTGAGACCCATGTTATCT
TTGGGATGTATAGCAACATTAAATTTGGTTTGTTTTGCTATGTACAGTCTGACTAATAACTGCTAATTTGTGATCCAACATGTACAGTAT
GTATATAGTGACATAGCTTACCAGTAGACCTTTAATGGAGACATGCATTTGCTAACTCATGGAACTGCAGACAGAAAGCACTCCATGCGA
AAACAGCCATTGCCTTTTTTAAAGATTTACCCTAGGACCTGATTTAAAGTGAATTTCAAGTGACCTGATTAATTTCCTATTCTTCCAAAT
GAGATGAAAATGGGGATCCTGTACAACCCTTTGTGGACCCTTTTGGTTTAGCTCTTAAGTAGGGGTATTTTCTACTGTTGCTTAATTATG
ATGGAAGATAACATTGTCATTCCTAGATGAATCCTTTGAAGTAACAAACATTGTATCTGACATCAGCTCTGTTCATGAGTGCTCAGAGTC
CCTGCTAATGTAATTGGAAGCTTGGTACACATAAGAAAAACTAGAGATTTGAAATCAGCTATGAATTACTCTATATAGTATCTATAGCCA
TGTACATATTACAGCATGACAAGCTCAAATAATTATGAGTCAGCCCGAAAGGATGTTAATTATGCCTACGATGTAATAACTATTGGAATG
TCATGGTCATTACATTTTTAGCTTCAGAGTTTATTTGAAAGTAATAATTGAAATCCTACAATTTATTTTAATCATTGGAAACTACCTTAA
TT

>7697_7697_5_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000504445_GABRA2_chr4_46252621_ENST00000356504_length(amino acids)=268AA_BP=
MDMTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVP
RNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVG
DFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLKKKRLPL

--------------------------------------------------------------
>7697_7697_6_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000504445_GABRA2_chr4_46252621_ENST00000381620_length(transcript)=2296nt_BP=1034nt
GAGCGGAGGGAGAAGTAGGTTGCGAGCTCAGCACAGGCTCCGGCGCTGGCTCCCGCAGCTGAGTTTGGGAGATGTCTAAGTGATTTTTTT
TTTTTCCCGGAAGGCAAATGGCTGGCGTGGAAGCACAACCCGCTTTCACTCTTCGAATTTGTGCTTAGCTCTTTTCTTGTACCTTGCGAC
TCGTGACCAACATGCTGTGATGTGTGCCGAGGGAGGAATTGGTCAGCTACACAACCTGGATCTTACCACAGTTTGGATATGACTGAGGCT
CTCCAATGGGCCAGATATCACTGGCGACGGCTGATCAGAGGTGCAACCAGGGATGATGATTCAGGGCCATACAACTATTCCTCGTTGCTC
GCCTGTGGGCGCAAGTCCTCTCAGACCCCTAAACTGTCAGGAAGGCACCGGATTGTTGTTCCCCACATCCAGCCCTTCAAGGATGAGTAT
GAGAAGTTCTCCGGAGCCTATGTGAACAATCGAATACGAACAACAAAGTACACACTTCTGAATTTTGTGCCAAGAAATTTATTTGAACAA
TTTCACAGAGCTGCCAATTTATATTTCCTGTTCCTAGTTGTCCTGAACTGGGTACCTTTGGTAGAAGCCTTCCAAAAGGAAATCACCATG
TTGCCTCTGGTGGTGGTCCTTACAATTATCGCAATTAAAGATGGCCTGGAAGATTATCGGAAATACAAAATTGACAAACAGATCAATAAT
TTAATAACTAAAGTTTATAGTAGGAAAGAGAAAAAATACATTGACCGATGCTGGAAAGACGTTACTGTTGGGGACTTTATTCGCCTCTCC
TGCAACGAGGTCATCCCTGCAGACATGGTACTACTCTTTTCCACTGATCCAGATGGAATCTGTCACATTGAGACTTCTGGTCTTGATGGA
GAGAGCAATTTAAAACAGAGGCAGGTGGTTCGGGGATATGCAGAACAGGACTCTGAAGTTGATCCTGAGAAGTTTTCCAGTAGGATAGAA
TGTGAAAGCCCAAACAATGACCTCAGCAGATTCCGAGGCTTCCTAAAAAAGAAAAGGCTTCCGTTATGATACAGAACAACGCTTATGCAG
TGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAAGATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGAACCCAACAAGA
AGCCAGAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATGTCCAGAATAGTTTTTCCAGTTTTGT
TTGGTACCTTTAATTTAGTTTACTGGGCTACATATTTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGAATTGAGACCCATGTTATCT
TTGGGATGTATAGCAACATTAAATTTGGTTTGTTTTGCTATGTACAGTCTGACTAATAACTGCTAATTTGTGATCCAACATGTACAGTAT
GTATATAGTGACATAGCTTACCAGTAGACCTTTAATGGAGACATGCATTTGCTAACTCATGGAACTGCAGACAGAAAGCACTCCATGCGA
AAACAGCCATTGCCTTTTTTAAAGATTTACCCTAGGACCTGATTTAAAGTGAATTTCAAGTGACCTGATTAATTTCCTATTCTTCCAAAT
GAGATGAAAATGGGGATCCTGTACAACCCTTTGTGGACCCTTTTGGTTTAGCTCTTAAGTAGGGGTATTTTCTACTGTTGCTTAATTATG
ATGGAAGATAACATTGTCATTCCTAGATGAATCCTTTGAAGTAACAAACATTGTATCTGACATCAGCTCTGTTCATGAGTGCTCAGAGTC
CCTGCTAATGTAATTGGAAGCTTGGTACACATAAGAAAAACTAGAGATTTGAAATCAGCTATGAATTACTCTATATAGTATCTATAGCCA
TGTACATATTACAGCATGACAAGCTCAAATAATTATGAGTCAGCCCGAAAGGATGTTAATTATGCCTACGATGTAATAACTATTGGAATG
TCATGGTCATTACATTTTTAGCTTCAGAGTTTATTTGAAAGTAATAATTGAAATCCTACAATTTATTTTAATCATTGGAAACTACCTTAA
TTAAAAAAAAAGAAAAGAAATGTGTCTTAACATTTCCAGGTATGTGTTGTATTGAAATTGATCAGCTAAATTTTACGGGTGCTGGAGACT
GGAAAAAGCATCCAGTTTGGTTGCTGTGGAGCAACATGCATATTGGATTAGAAAATTGTGCCAAAAACTCCCACTGATGAGAATTCATAG
GTGCCCCACACTATGACAAACACTTATATGATTCTCCTCTTTCCTG

>7697_7697_6_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000504445_GABRA2_chr4_46252621_ENST00000381620_length(amino acids)=268AA_BP=
MDMTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVP
RNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVG
DFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLKKKRLPL

--------------------------------------------------------------
>7697_7697_7_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000504445_GABRA2_chr4_46252621_ENST00000507069_length(transcript)=1350nt_BP=1034nt
GAGCGGAGGGAGAAGTAGGTTGCGAGCTCAGCACAGGCTCCGGCGCTGGCTCCCGCAGCTGAGTTTGGGAGATGTCTAAGTGATTTTTTT
TTTTTCCCGGAAGGCAAATGGCTGGCGTGGAAGCACAACCCGCTTTCACTCTTCGAATTTGTGCTTAGCTCTTTTCTTGTACCTTGCGAC
TCGTGACCAACATGCTGTGATGTGTGCCGAGGGAGGAATTGGTCAGCTACACAACCTGGATCTTACCACAGTTTGGATATGACTGAGGCT
CTCCAATGGGCCAGATATCACTGGCGACGGCTGATCAGAGGTGCAACCAGGGATGATGATTCAGGGCCATACAACTATTCCTCGTTGCTC
GCCTGTGGGCGCAAGTCCTCTCAGACCCCTAAACTGTCAGGAAGGCACCGGATTGTTGTTCCCCACATCCAGCCCTTCAAGGATGAGTAT
GAGAAGTTCTCCGGAGCCTATGTGAACAATCGAATACGAACAACAAAGTACACACTTCTGAATTTTGTGCCAAGAAATTTATTTGAACAA
TTTCACAGAGCTGCCAATTTATATTTCCTGTTCCTAGTTGTCCTGAACTGGGTACCTTTGGTAGAAGCCTTCCAAAAGGAAATCACCATG
TTGCCTCTGGTGGTGGTCCTTACAATTATCGCAATTAAAGATGGCCTGGAAGATTATCGGAAATACAAAATTGACAAACAGATCAATAAT
TTAATAACTAAAGTTTATAGTAGGAAAGAGAAAAAATACATTGACCGATGCTGGAAAGACGTTACTGTTGGGGACTTTATTCGCCTCTCC
TGCAACGAGGTCATCCCTGCAGACATGGTACTACTCTTTTCCACTGATCCAGATGGAATCTGTCACATTGAGACTTCTGGTCTTGATGGA
GAGAGCAATTTAAAACAGAGGCAGGTGGTTCGGGGATATGCAGAACAGGACTCTGAAGTTGATCCTGAGAAGTTTTCCAGTAGGATAGAA
TGTGAAAGCCCAAACAATGACCTCAGCAGATTCCGAGGCTTCCTAAAAAAGAAAAGGCTTCCGTTATGATACAGAACAACGCTTATGCAG
TGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAAGATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGAACCCAACAAGA
AGCCAGAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATGTCCAGAATAGTTTTTCCAGTTTTGT
TTGGTACCTTTAATTTAGTTTACTGGGCTACATATTTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGAATTGAGACCCATGTTATCT


>7697_7697_7_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000504445_GABRA2_chr4_46252621_ENST00000507069_length(amino acids)=268AA_BP=
MDMTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVP
RNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVG
DFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLKKKRLPL

--------------------------------------------------------------
>7697_7697_8_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000504445_GABRA2_chr4_46252621_ENST00000510861_length(transcript)=3212nt_BP=1034nt
GAGCGGAGGGAGAAGTAGGTTGCGAGCTCAGCACAGGCTCCGGCGCTGGCTCCCGCAGCTGAGTTTGGGAGATGTCTAAGTGATTTTTTT
TTTTTCCCGGAAGGCAAATGGCTGGCGTGGAAGCACAACCCGCTTTCACTCTTCGAATTTGTGCTTAGCTCTTTTCTTGTACCTTGCGAC
TCGTGACCAACATGCTGTGATGTGTGCCGAGGGAGGAATTGGTCAGCTACACAACCTGGATCTTACCACAGTTTGGATATGACTGAGGCT
CTCCAATGGGCCAGATATCACTGGCGACGGCTGATCAGAGGTGCAACCAGGGATGATGATTCAGGGCCATACAACTATTCCTCGTTGCTC
GCCTGTGGGCGCAAGTCCTCTCAGACCCCTAAACTGTCAGGAAGGCACCGGATTGTTGTTCCCCACATCCAGCCCTTCAAGGATGAGTAT
GAGAAGTTCTCCGGAGCCTATGTGAACAATCGAATACGAACAACAAAGTACACACTTCTGAATTTTGTGCCAAGAAATTTATTTGAACAA
TTTCACAGAGCTGCCAATTTATATTTCCTGTTCCTAGTTGTCCTGAACTGGGTACCTTTGGTAGAAGCCTTCCAAAAGGAAATCACCATG
TTGCCTCTGGTGGTGGTCCTTACAATTATCGCAATTAAAGATGGCCTGGAAGATTATCGGAAATACAAAATTGACAAACAGATCAATAAT
TTAATAACTAAAGTTTATAGTAGGAAAGAGAAAAAATACATTGACCGATGCTGGAAAGACGTTACTGTTGGGGACTTTATTCGCCTCTCC
TGCAACGAGGTCATCCCTGCAGACATGGTACTACTCTTTTCCACTGATCCAGATGGAATCTGTCACATTGAGACTTCTGGTCTTGATGGA
GAGAGCAATTTAAAACAGAGGCAGGTGGTTCGGGGATATGCAGAACAGGACTCTGAAGTTGATCCTGAGAAGTTTTCCAGTAGGATAGAA
TGTGAAAGCCCAAACAATGACCTCAGCAGATTCCGAGGCTTCCTAAAAAAGAAAAGGCTTCCGTTATGATACAGAACAACGCTTATGCAG
TGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAAGATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGAACCCAACAAGA
AGCCAGAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATGTCCAGAATAGTTTTTCCAGTTTTGT
TTGGTACCTTTAATTTAGTTTACTGGGCTACATATTTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGAATTGAGACCCATGTTATCT
TTGGGATGTATAGCAACATTAAATTTGGTTTGTTTTGCTATGTACAGTCTGACTAATAACTGCTAATTTGTGATCCAACATGTACAGTAT
GTATATAGTGACATAGCTTACCAGTAGACCTTTAATGGAGACATGCATTTGCTAACTCATGGAACTGCAGACAGAAAGCACTCCATGCGA
AAACAGCCATTGCCTTTTTTAAAGATTTACCCTAGGACCTGATTTAAAGTGAATTTCAAGTGACCTGATTAATTTCCTATTCTTCCAAAT
GAGATGAAAATGGGGATCCTGTACAACCCTTTGTGGACCCTTTTGGTTTAGCTCTTAAGTAGGGGTATTTTCTACTGTTGCTTAATTATG
ATGGAAGATAACATTGTCATTCCTAGATGAATCCTTTGAAGTAACAAACATTGTATCTGACATCAGCTCTGTTCATGAGTGCTCAGAGTC
CCTGCTAATGTAATTGGAAGCTTGGTACACATAAGAAAAACTAGAGATTTGAAATCAGCTATGAATTACTCTATATAGTATCTATAGCCA
TGTACATATTACAGCATGACAAGCTCAAATAATTATGAGTCAGCCCGAAAGGATGTTAATTATGCCTACGATGTAATAACTATTGGAATG
TCATGGTCATTACATTTTTAGCTTCAGAGTTTATTTGAAAGTAATAATTGAAATCCTACAATTTATTTTAATCATTGGAAACTACCTTAA
TTAAAAAAAAAGAAAAGAAATGTGTCTTAACATTTCCAGGTATGTGTTGTATTGAAATTGATCAGCTAAATTTTACGGGTGCTGGAGACT
GGAAAAAGCATCCAGTTTGGTTGCTGTGGAGCAACATGCATATTGGATTAGAAAATTGTGCCAAAAACTCCCACTGATGAGAATTCATAG
GTGCCCCACACTATGACAAACACTTATATGATTCTCCTCTTTCCTGTTTACTGCAAATTCTGCCTTAAGGCTTCTTTTCAAGACTCAGAA
GCCACTAATTATAAAGGAAAGGGCAGTTAATTGGCACATTTTTCTCTTGTGAAAGCAGTTCTTTCAGATAAGAATTAATGTAAATCTGCT
TTTGTAAATTGCAACTTTAAATTTCGCTGACTCAAATTTACAACAGCTTTGTATACCAGAAGAGGTTTTGGTAAGGGTTGAACATTTTTA
CACTGCAACTTTAAAACATCACCAATAGATTGTGGATTATTTCACGTGCACAAACATACACACACACACACACACACACACACATACACA
GCTAAATTAGAAAACACAATTTTAAATTTTATATAATTACTAGTTATTAATGGGTAAAATTCATTTTTCTTTTAATATCTTAAAATATTA
TTTATGCCCCGAAATATGCTAATAAAAGTTAAAGATTGTGTATTATGCCTAGATTCAAAGTTTTTGGCAAACTTCAAATACTTTTGATTG
ACATGTACATTAGCAGTTATTAGTTGACTTTTACTAAAACATGCACCTTTACGATGGTGTTTTTGTAGAAACATAAGTAGTCAAATAGTA
ACATTTATTGCAGTTTTGTACAGTATTTGAGTATAGTGCATAAATAGGTATGTTCATAAAATCAATAAAAGGAGTATCTATGGAAATAAG
CAAAATATCAGCAAAAATTGCTATTCCTTTGCCTCATTTAATTTTTAAAATTTCTTTGTTTCCATGTGATTCTATTATATGCTTTGCATG
CTTGTATAAAACCAAGGTCACAAATGCAACTTATTAACGGAATTTGCCAAGAAGACAGCCTTGACATTAAAAATTCCCTCACAAGAGGTA
ATCCATAATCCTTAATAAAATAAAATTGTTACATGAGCCAATAAATGTATTTCTTTAATTCC

>7697_7697_8_ATP10D-GABRA2_ATP10D_chr4_47527659_ENST00000504445_GABRA2_chr4_46252621_ENST00000510861_length(amino acids)=268AA_BP=
MDMTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVP
RNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVG
DFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLKKKRLPL

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Fusion Gene PPI Analysis for ATP10D-GABRA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP10D-GABRA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP10D-GABRA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP10DC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0001973Alcoholic Intoxication, Chronic6CTD_human;PSYGENET
TgeneC0600427Cocaine Dependence3CTD_human;PSYGENET
TgeneC0009171Cocaine Abuse2CTD_human
TgeneC0236736Cocaine-Related Disorders2CTD_human
TgeneC0001956Alcohol Use Disorder1CTD_human
TgeneC0003469Anxiety Disorders1CTD_human
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0006870Cannabis Dependence1PSYGENET
TgeneC0019337Heroin Dependence1CTD_human
TgeneC0085762Alcohol abuse1CTD_human
TgeneC0376280Anxiety States, Neurotic1CTD_human
TgeneC0424605Developmental delay (disorder)1GENOMICS_ENGLAND
TgeneC0557874Global developmental delay1GENOMICS_ENGLAND
TgeneC0600241heroin abuse1CTD_human
TgeneC1279420Anxiety neurosis (finding)1CTD_human
TgeneC3160814Cannabis use1PSYGENET
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4505390Heroin Smoking1CTD_human