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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PLEKHG5-TNFRSF8 (FusionGDB2 ID:HG57449TG943)

Fusion Gene Summary for PLEKHG5-TNFRSF8

Fusion gene summary

Fusion gene information	Fusion gene name: PLEKHG5-TNFRSF8
	Fusion gene ID: hg57449tg943
		Hgene	Tgene
	Gene symbol	PLEKHG5	TNFRSF8
	Gene ID	57449	943
	Gene name	pleckstrin homology and RhoGEF domain containing G5	TNF receptor superfamily member 8
	Synonyms	CMTRIC\|DSMA4\|GEF720\|Syx\|Tech	CD30\|D1S166E\|Ki-1
	Cytomap	('PLEKHG5')('TNFRSF8') 1p36.31	1p36.22
	Type of gene	protein-coding	protein-coding
	Description	pleckstrin homology domain-containing family G member 5NFkB activating proteinPH domain-containing family G member 5guanine nucleotide exchange factor 720novel PH domain-containing proteinpleckstrin homology domain containing, family G (with RhoGef d	tumor necrosis factor receptor superfamily member 8CD30L receptorKi-1 antigencytokine receptor CD30lymphocyte activation antigen CD30
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000377732, ENST00000377740, ENST00000377748, ENST00000400915, ENST00000537245, ENST00000377737, ENST00000544978, ENST00000340850, ENST00000377725, ENST00000377728, ENST00000400913, ENST00000535355,
Fusion gene scores	* DoF score	4 X 4 X 4=64	5 X 6 X 5=150
	# samples	5	5
	** MAII score	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/150*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PLEKHG5 [Title/Abstract] AND TNFRSF8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PLEKHG5(6556553)-TNFRSF8(12202344), # samples:1 PLEKHG5(6556553)-TNFRSF8(12198286), # samples:1
Anticipated loss of major functional domain due to fusion event.	PLEKHG5-TNFRSF8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLEKHG5-TNFRSF8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLEKHG5-TNFRSF8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PLEKHG5-TNFRSF8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PLEKHG5-TNFRSF8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TNFRSF8	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	16108830
Tgene	TNFRSF8	GO:0043065	positive regulation of apoptotic process	16108830
Tgene	TNFRSF8	GO:0045556	positive regulation of TRAIL biosynthetic process	16108830

Fusion gene breakpoints across PLEKHG5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TNFRSF8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-MP-A4SW-01A	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
ChimerDB4	LUAD	TCGA-MP-A4SW-01A	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+

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Fusion Gene ORF analysis for PLEKHG5-TNFRSF8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000377732	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5CDS-3UTR	ENST00000377740	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5CDS-3UTR	ENST00000377748	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5CDS-3UTR	ENST00000400915	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5CDS-3UTR	ENST00000537245	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5CDS-5UTR	ENST00000377732	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5CDS-5UTR	ENST00000377740	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5CDS-5UTR	ENST00000377748	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5CDS-5UTR	ENST00000400915	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5CDS-5UTR	ENST00000537245	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5CDS-intron	ENST00000377732	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5CDS-intron	ENST00000377740	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5CDS-intron	ENST00000377748	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5CDS-intron	ENST00000400915	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5CDS-intron	ENST00000537245	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5UTR-3CDS	ENST00000377737	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5UTR-3CDS	ENST00000377737	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5UTR-3CDS	ENST00000377737	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5UTR-3CDS	ENST00000377737	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5UTR-3CDS	ENST00000377737	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5UTR-3CDS	ENST00000544978	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5UTR-3CDS	ENST00000544978	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5UTR-3CDS	ENST00000544978	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5UTR-3CDS	ENST00000544978	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5UTR-3CDS	ENST00000544978	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5UTR-3UTR	ENST00000377737	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5UTR-3UTR	ENST00000544978	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
5UTR-5UTR	ENST00000377737	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5UTR-5UTR	ENST00000544978	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5UTR-intron	ENST00000377737	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
5UTR-intron	ENST00000544978	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
Frame-shift	ENST00000377732	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000377732	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000377732	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000377740	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000377740	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000377740	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000377748	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000377748	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000377748	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000400915	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000400915	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000400915	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000537245	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000537245	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
Frame-shift	ENST00000537245	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
In-frame	ENST00000377732	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
In-frame	ENST00000377732	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
In-frame	ENST00000377740	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
In-frame	ENST00000377740	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
In-frame	ENST00000377748	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
In-frame	ENST00000377748	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
In-frame	ENST00000400915	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
In-frame	ENST00000400915	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
In-frame	ENST00000537245	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
In-frame	ENST00000537245	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000340850	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000340850	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000340850	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000340850	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000340850	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000377725	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000377725	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000377725	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000377725	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000377725	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000377728	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000377728	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000377728	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000377728	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000377728	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000400913	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000400913	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000400913	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000400913	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000400913	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000535355	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000535355	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000535355	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3CDS	ENST00000535355	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-3CDS	ENST00000535355	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3UTR	ENST00000340850	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3UTR	ENST00000377725	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3UTR	ENST00000377728	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3UTR	ENST00000400913	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-3UTR	ENST00000535355	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12202344	+
intron-5UTR	ENST00000340850	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-5UTR	ENST00000377725	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-5UTR	ENST00000377728	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-5UTR	ENST00000400913	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-5UTR	ENST00000535355	ENST00000413146	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-intron	ENST00000340850	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-intron	ENST00000377725	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-intron	ENST00000377728	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-intron	ENST00000400913	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+
intron-intron	ENST00000535355	ENST00000479933	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000377748	PLEKHG5	chr1	6556553	-	ENST00000263932	TNFRSF8	chr1	12198286	+	2771	642	438	1094	218
ENST00000377748	PLEKHG5	chr1	6556553	-	ENST00000417814	TNFRSF8	chr1	12198286	+	1678	642	438	1091	217
ENST00000377732	PLEKHG5	chr1	6556553	-	ENST00000263932	TNFRSF8	chr1	12198286	+	2333	204	15	656	213
ENST00000377732	PLEKHG5	chr1	6556553	-	ENST00000417814	TNFRSF8	chr1	12198286	+	1240	204	15	653	212
ENST00000400915	PLEKHG5	chr1	6556553	-	ENST00000263932	TNFRSF8	chr1	12198286	+	2277	148	67	600	177
ENST00000400915	PLEKHG5	chr1	6556553	-	ENST00000417814	TNFRSF8	chr1	12198286	+	1184	148	67	597	176
ENST00000377740	PLEKHG5	chr1	6556553	-	ENST00000263932	TNFRSF8	chr1	12198286	+	2823	694	490	1146	218
ENST00000377740	PLEKHG5	chr1	6556553	-	ENST00000417814	TNFRSF8	chr1	12198286	+	1730	694	490	1143	217
ENST00000537245	PLEKHG5	chr1	6556553	-	ENST00000263932	TNFRSF8	chr1	12198286	+	2344	215	65	667	200
ENST00000537245	PLEKHG5	chr1	6556553	-	ENST00000417814	TNFRSF8	chr1	12198286	+	1251	215	65	664	199

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377748	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.009907883	0.9900921
ENST00000377748	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.014892456	0.9851075
ENST00000377732	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.019401288	0.9805987
ENST00000377732	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.009944749	0.9900552
ENST00000400915	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.008668623	0.99133134
ENST00000400915	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.00667193	0.9933281
ENST00000377740	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.013230377	0.98676956
ENST00000377740	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.019239746	0.9807602
ENST00000537245	ENST00000263932	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.013414326	0.9865856
ENST00000537245	ENST00000417814	PLEKHG5	chr1	6556553	-	TNFRSF8	chr1	12198286	+	0.011713862	0.9882861

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Fusion Genomic Features for PLEKHG5-TNFRSF8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PLEKHG5	chr1	6556552	-	TNFRSF8	chr1	12202343	+	7.71E-08	0.9999999
PLEKHG5	chr1	6556552	-	TNFRSF8	chr1	12198288	+	8.60E-08	0.9999999
PLEKHG5	chr1	6556552	-	TNFRSF8	chr1	12202343	+	7.71E-08	0.9999999
PLEKHG5	chr1	6556552	-	TNFRSF8	chr1	12198288	+	8.60E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PLEKHG5-TNFRSF8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6556553/chr1:12202344)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377748

38_43

1084.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000537245

38_43

1086.0

Compositional bias

Note=Poly-Glu

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

347_377

133.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

107_150

133.0

Repeat

Note=TNFR-Cys 3

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

205_241

133.0

Repeat

Note=TNFR-Cys 4

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

243_281

133.0

Repeat

Note=TNFR-Cys 5

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

282_325

133.0

Repeat

Note=TNFR-Cys 6

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

28_66

133.0

Repeat

Note=TNFR-Cys 1

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

68_106

133.0

Repeat

Note=TNFR-Cys 2

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

19_385

133.0

Topological domain

Extracellular

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

407_595

133.0

Topological domain

Cytoplasmic

Tgene

TNFRSF8

chr1:6556553

chr1:12198286

ENST00000413146

386_406

133.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000340850

38_43

1007.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377725

38_43

1020.6666666666666

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377728

38_43

1007.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377732

38_43

1044.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377737

38_43

1007.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000400913

38_43

1007.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000400915

38_43

1063.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000535355

38_43

1076.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000544978

38_43

931.0

Compositional bias

Note=Poly-Glu

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000340850

336_528

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000340850

584_684

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377725

336_528

1020.6666666666666

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377725

584_684

1020.6666666666666

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377728

336_528

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377728

584_684

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377732

336_528

1044.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377732

584_684

1044.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377737

336_528

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377737

584_684

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377748

336_528

1084.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000377748

584_684

1084.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000400913

336_528

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000400913

584_684

1007.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000400915

336_528

1063.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000400915

584_684

1063.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000535355

336_528

1076.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000535355

584_684

1076.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000537245

336_528

1086.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000537245

584_684

1086.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000544978

336_528

931.0

Domain

Hgene

PLEKHG5

chr1:6556553

chr1:12198286

ENST00000544978

584_684

931.0

Domain

Top

Fusion Gene Sequence for PLEKHG5-TNFRSF8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>66279_66279_1_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377732_TNFRSF8_chr1_12198286_ENST00000263932_length(transcript)=2333nt_BP=204nt
GGACGCTGACCTCTTTTGAAGGGAGGACTGAGGAGATCACCCCACCCCTCCTCCGGTTGGGAGGCCAGTGGGGCCCAGGGGAGCCTGGGT
GCCCCGCTGACTGATGCCCTCTGCTCCTCCCCTGCAGACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGC
ATGGACAAGGGGCGGGCGGCCAAGCAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCGGAAGAGCGAGGGTTAATGAGCCAGCCA
CTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCC
AGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTACATCATGAAGGCTGACACCGTGATCGTG
GGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAGTTGGAGGAGGAGCTGGAGGCGGACCATACC
CCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCAGTGGAAGAGGAAGGGAAAGAAGACCCC
TTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCAGGGTGGCCTCTGGGAGGCCAGGATGGCACT
GTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAGTGGTGGACCGGCCGGTCACTGCAGGGGTCT
GGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCGGGGCTTGTACAGAAGAGACAGTCCAAGGGG
ACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCCGAGAACAGCATTGGTCCCAGAGCCCTGGGC
ATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCCGGGGCCCCTGTAACCCTACTCTCCTCTCTC
CCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAATGTGGCCCCCAGTGGGCATGGAGCCAGTGCC
TGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAGCTGGCACTGTCTCTGCTGCAGCGGCCACACTGTACTC
TGCACTGGTGTGAGGGCCCCTGCCTGGACTGTGGGACCCTCCTGGTGCTGCCCACCTTCCCTGTCCTGTAGCCCCCTCGGTGGGCCCAGG
GCCTAGGGCCCAGGATCAAGTCACTCATCTCAGAATGTCCCCACCAATCCCCGCCACAGCAGGCGCCTCGGGTCCCAGATGTCTGCAGCC
CTCAGCAGCTGCAGACCGCCCCTCACCAACCCAGAGAACCTGCTTTACTTTGCCCAGGGACTTCCTCCCCATGTGAACATGGGGAACTTC
GGGCCCTGCCTGGAGTCCTTGACCGCTCTCTGTGGGCCCCACCCACTCTGTCCTGGGAAATGAAGAAGCATCTTCCTTAGGTCTGCCCTG
CTTGCAAATCCACTAGCACCGACCCCACCACCTGGTTCCGGCTCTGCACGCTTTGGGGTGTGGATGTCGAGAGGCACCACGGCCTCACCC
AGGCATCTGCTTTACTCTGGACCATAGGAAACAAGACCGTTTGGAGGTTTCATCAGGATTTTGGGTTTTTCACATTTCACGCTAAGGAGT
AGTGGCCCTGACTTCCGGTCGGCTGGCCAGCTGACTCCCTAGGGCCTTCAGACGTGTATGCAAATGAGTGATGGATAAGGATGAGTCTTG
GAGTTGCGGGCAGCCTGGAGACTCGTGGACTTACCGCCTGGAGGCAGGCCCGGGAAGGCTGCTGTTTACTCATCGGGCAGCCACGTGCTC
TCTGGAGGAAGTGATAGTTTCTGAAACCGCTCAGATGTTTTGGGGAAAGTTGGAGAAGCCGTGGCCTTGCGAGAGGTGGTTACACCAGAA
CCTGGACATTGGCCAGAAGAAGCTTAAGTGGGCAGACACTGTTTGCCCAGTGTTTGTGCAAGGATGGAGTGGGTGTCTCTGCATCACCCA
CAGCCGCAGCTGTAAGGCACGCTGGAAGGCACACGCCTGCCAGGCAGGGCAGTCTGGCGCCCATGATGGGAGGGATTGACATGTTTCAAC

>66279_66279_1_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377732_TNFRSF8_chr1_12198286_ENST00000263932_length(amino acids)=213AA_BP=63
MKGGLRRSPHPSSGWEASGAQGSLGAPLTDALCSSPADDQSPAEKKGLRCQNPACMDKGRAAKQLRSGASVTEPVAEERGLMSQPLMETC
HSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPE

--------------------------------------------------------------
>66279_66279_2_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377732_TNFRSF8_chr1_12198286_ENST00000417814_length(transcript)=1240nt_BP=204nt
GGACGCTGACCTCTTTTGAAGGGAGGACTGAGGAGATCACCCCACCCCTCCTCCGGTTGGGAGGCCAGTGGGGCCCAGGGGAGCCTGGGT
GCCCCGCTGACTGATGCCCTCTGCTCCTCCCCTGCAGACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGC
ATGGACAAGGGGCGGGCGGCCAAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCGGAAGAGCGAGGGTTAATGAGCCAGCCACTG
ATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGG
GACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTACATCATGAAGGCTGACACCGTGATCGTGGGG
ACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAGTTGGAGGAGGAGCTGGAGGCGGACCATACCCCC
CACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTG
CCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCAGGGTGGCCTCTGGGAGGCCAGGATGGCACTGTT
GGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAGTGGTGGACCGGCCGGTCACTGCAGGGGTCTGGT
GGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCGGGGCTTGTACAGAAGAGACAGTCCAAGGGGACT
GGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCCGAGAACAGCATTGGTCCCAGAGCCCTGGGCATC
AGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCCGGGGCCCCTGTAACCCTACTCTCCTCTCTCCCT
GGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAATGTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGT

>66279_66279_2_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377732_TNFRSF8_chr1_12198286_ENST00000417814_length(amino acids)=212AA_BP=63
MKGGLRRSPHPSSGWEASGAQGSLGAPLTDALCSSPADDQSPAEKKGLRCQNPACMDKGRAAKLRSGASVTEPVAEERGLMSQPLMETCH
SVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQ

--------------------------------------------------------------
>66279_66279_3_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377740_TNFRSF8_chr1_12198286_ENST00000263932_length(transcript)=2823nt_BP=694nt
CTTGATCTCCCGCTGTGACCAGCCCCTCTCTGCCTGGCAGGGGAAAGCCACCAAACTAAGGCCTTCCTGGTAGCCAAGGAGCCCAGCAGA
GGGGCTGCTGCTGGCTGCTGGGATTGCAGAGGCCGGGGTCTCTGTGGTGTTGCTTTCCTGGAAAGGAGGGACGGCACCTCCAGGGCAGCC
AGCAGTGTGGGAGCCCATTCCAGGGCGCAAATGGGCACTCAGGAATGGAAAATCCAAGAAGGAACCAACCACCAACAAGGAAATGCAGTG
TGAGCGGCGGCTGCGAAGTCTGTGCCTTCAAATATACAGCGCCCAGGGGACCTGTGTTGGACGGGGAGCAAATTGGCAGGGCTGAGAGCG
CCTTGGTTTTCTGTGCAGACAGGTCCAGCTGCAGAAATTAAGACTGGGGCTGAGTCGGGGAGAAGCCTTCCATGTTGAGATGGCAACTGG
GCAAAGCAGGACGGAGACCTGTGTGTCTGATTAGAGAGGCCTGTGGCATTGGCATGTGGCTGGAGGTCCAGGCAGGGTGCCACCACCGCA
GAGGTCAAGCATGAATTCAGTCCTGACAAAACATGGGTCTCCACCTCGAAGCTGGCTCAGCCTTTGTTCAGGAACCGACGACCAGAGCCC
CGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGCAGCTGAGGAGTGGTGCGTCGGTGAC
AGAACCCGTCGCGGAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCC
GCTGCAGGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGAT
TGAGAAAATCTACATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGC
AGAGCCCGAGTTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGA
TGTCATGCTCTCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAG
GAGGGCAGCAGGGTGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTC
CAGCATCTAGTGGTGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCT
AGGGGATCCGGGGCTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGAT
GGGCACTGCCGAGAACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAG
GCCAGCTCCCGGGGCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGT
TACTGTAAATGTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGT
CAGCTGGCACTGTCTCTGCTGCAGCGGCCACACTGTACTCTGCACTGGTGTGAGGGCCCCTGCCTGGACTGTGGGACCCTCCTGGTGCTG
CCCACCTTCCCTGTCCTGTAGCCCCCTCGGTGGGCCCAGGGCCTAGGGCCCAGGATCAAGTCACTCATCTCAGAATGTCCCCACCAATCC
CCGCCACAGCAGGCGCCTCGGGTCCCAGATGTCTGCAGCCCTCAGCAGCTGCAGACCGCCCCTCACCAACCCAGAGAACCTGCTTTACTT
TGCCCAGGGACTTCCTCCCCATGTGAACATGGGGAACTTCGGGCCCTGCCTGGAGTCCTTGACCGCTCTCTGTGGGCCCCACCCACTCTG
TCCTGGGAAATGAAGAAGCATCTTCCTTAGGTCTGCCCTGCTTGCAAATCCACTAGCACCGACCCCACCACCTGGTTCCGGCTCTGCACG
CTTTGGGGTGTGGATGTCGAGAGGCACCACGGCCTCACCCAGGCATCTGCTTTACTCTGGACCATAGGAAACAAGACCGTTTGGAGGTTT
CATCAGGATTTTGGGTTTTTCACATTTCACGCTAAGGAGTAGTGGCCCTGACTTCCGGTCGGCTGGCCAGCTGACTCCCTAGGGCCTTCA
GACGTGTATGCAAATGAGTGATGGATAAGGATGAGTCTTGGAGTTGCGGGCAGCCTGGAGACTCGTGGACTTACCGCCTGGAGGCAGGCC
CGGGAAGGCTGCTGTTTACTCATCGGGCAGCCACGTGCTCTCTGGAGGAAGTGATAGTTTCTGAAACCGCTCAGATGTTTTGGGGAAAGT
TGGAGAAGCCGTGGCCTTGCGAGAGGTGGTTACACCAGAACCTGGACATTGGCCAGAAGAAGCTTAAGTGGGCAGACACTGTTTGCCCAG
TGTTTGTGCAAGGATGGAGTGGGTGTCTCTGCATCACCCACAGCCGCAGCTGTAAGGCACGCTGGAAGGCACACGCCTGCCAGGCAGGGC
AGTCTGGCGCCCATGATGGGAGGGATTGACATGTTTCAACAAAATAATGCACTTCCTTACCTAGTGGCCCTTCACACAACTTTTGAATCT

>66279_66279_3_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377740_TNFRSF8_chr1_12198286_ENST00000263932_length(amino acids)=218AA_BP=68
MWHWHVAGGPGRVPPPQRSSMNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKQLRSGASVTEPVAEERGLMSQP
LMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHT

--------------------------------------------------------------
>66279_66279_4_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377740_TNFRSF8_chr1_12198286_ENST00000417814_length(transcript)=1730nt_BP=694nt
CTTGATCTCCCGCTGTGACCAGCCCCTCTCTGCCTGGCAGGGGAAAGCCACCAAACTAAGGCCTTCCTGGTAGCCAAGGAGCCCAGCAGA
GGGGCTGCTGCTGGCTGCTGGGATTGCAGAGGCCGGGGTCTCTGTGGTGTTGCTTTCCTGGAAAGGAGGGACGGCACCTCCAGGGCAGCC
AGCAGTGTGGGAGCCCATTCCAGGGCGCAAATGGGCACTCAGGAATGGAAAATCCAAGAAGGAACCAACCACCAACAAGGAAATGCAGTG
TGAGCGGCGGCTGCGAAGTCTGTGCCTTCAAATATACAGCGCCCAGGGGACCTGTGTTGGACGGGGAGCAAATTGGCAGGGCTGAGAGCG
CCTTGGTTTTCTGTGCAGACAGGTCCAGCTGCAGAAATTAAGACTGGGGCTGAGTCGGGGAGAAGCCTTCCATGTTGAGATGGCAACTGG
GCAAAGCAGGACGGAGACCTGTGTGTCTGATTAGAGAGGCCTGTGGCATTGGCATGTGGCTGGAGGTCCAGGCAGGGTGCCACCACCGCA
GAGGTCAAGCATGAATTCAGTCCTGACAAAACATGGGTCTCCACCTCGAAGCTGGCTCAGCCTTTGTTCAGGAACCGACGACCAGAGCCC
CGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGCTGAGGAGTGGTGCGTCGGTGACAGA
ACCCGTCGCGGAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCT
GCAGGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGA
GAAAATCTACATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGA
GCCCGAGTTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGT
CATGCTCTCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAG
GGCAGCAGGGTGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAG
CATCTAGTGGTGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGG
GGATCCGGGGCTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGG
CACTGCCGAGAACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCC
AGCTCCCGGGGCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTAC
TGTAAATGTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAG

>66279_66279_4_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377740_TNFRSF8_chr1_12198286_ENST00000417814_length(amino acids)=217AA_BP=68
MWHWHVAGGPGRVPPPQRSSMNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKLRSGASVTEPVAEERGLMSQPL
METCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTP

--------------------------------------------------------------
>66279_66279_5_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377748_TNFRSF8_chr1_12198286_ENST00000263932_length(transcript)=2771nt_BP=642nt
AAACTAAGGCCTTCCTGGTAGCCAAGGAGCCCAGCAGAGGGGCTGCTGCTGGCTGCTGGGATTGCAGAGGCCGGGGTCTCTGTGGTGTTG
CTTTCCTGGAAAGGAGGGACGGCACCTCCAGGGCAGCCAGCAGTGTGGGAGCCCATTCCAGGGCGCAAATGGGCACTCAGGAATGGAAAA
TCCAAGAAGGAACCAACCACCAACAAGGAAATGCAGTGTGAGCGGCGGCTGCGAAGTCTGTGCCTTCAAATATACAGCGCCCAGGGGACC
TGTGTTGGACGGGGAGCAAATTGGCAGGGCTGAGAGCGCCTTGGTTTTCTGTGCAGACAGGTCCAGCTGCAGAAATTAAGACTGGGGCTG
AGTCGGGGAGAAGCCTTCCATGTTGAGATGGCAACTGGGCAAAGCAGGACGGAGACCTGTGTGTCTGATTAGAGAGGCCTGTGGCATTGG
CATGTGGCTGGAGGTCCAGGCAGGGTGCCACCACCGCAGAGGTCAAGCATGAATTCAGTCCTGACAAAACATGGGTCTCCACCTCGAAGC
TGGCTCAGCCTTTGTTCAGGAACCGACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGG
CGGGCGGCCAAGCAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCGGAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACC
TGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCT
GAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTACATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAG
GCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAGTTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCC
GAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCT
GCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCAGGGTGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAG
GTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAGTGGTGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGC
TTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCGGGGCTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAG
CAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCCGAGAACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAA
CCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCCGGGGCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAG
AGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAATGTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTC
TCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAGCTGGCACTGTCTCTGCTGCAGCGGCCACACTGTACTCTGCACTGGTGTG
AGGGCCCCTGCCTGGACTGTGGGACCCTCCTGGTGCTGCCCACCTTCCCTGTCCTGTAGCCCCCTCGGTGGGCCCAGGGCCTAGGGCCCA
GGATCAAGTCACTCATCTCAGAATGTCCCCACCAATCCCCGCCACAGCAGGCGCCTCGGGTCCCAGATGTCTGCAGCCCTCAGCAGCTGC
AGACCGCCCCTCACCAACCCAGAGAACCTGCTTTACTTTGCCCAGGGACTTCCTCCCCATGTGAACATGGGGAACTTCGGGCCCTGCCTG
GAGTCCTTGACCGCTCTCTGTGGGCCCCACCCACTCTGTCCTGGGAAATGAAGAAGCATCTTCCTTAGGTCTGCCCTGCTTGCAAATCCA
CTAGCACCGACCCCACCACCTGGTTCCGGCTCTGCACGCTTTGGGGTGTGGATGTCGAGAGGCACCACGGCCTCACCCAGGCATCTGCTT
TACTCTGGACCATAGGAAACAAGACCGTTTGGAGGTTTCATCAGGATTTTGGGTTTTTCACATTTCACGCTAAGGAGTAGTGGCCCTGAC
TTCCGGTCGGCTGGCCAGCTGACTCCCTAGGGCCTTCAGACGTGTATGCAAATGAGTGATGGATAAGGATGAGTCTTGGAGTTGCGGGCA
GCCTGGAGACTCGTGGACTTACCGCCTGGAGGCAGGCCCGGGAAGGCTGCTGTTTACTCATCGGGCAGCCACGTGCTCTCTGGAGGAAGT
GATAGTTTCTGAAACCGCTCAGATGTTTTGGGGAAAGTTGGAGAAGCCGTGGCCTTGCGAGAGGTGGTTACACCAGAACCTGGACATTGG
CCAGAAGAAGCTTAAGTGGGCAGACACTGTTTGCCCAGTGTTTGTGCAAGGATGGAGTGGGTGTCTCTGCATCACCCACAGCCGCAGCTG
TAAGGCACGCTGGAAGGCACACGCCTGCCAGGCAGGGCAGTCTGGCGCCCATGATGGGAGGGATTGACATGTTTCAACAAAATAATGCAC

>66279_66279_5_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377748_TNFRSF8_chr1_12198286_ENST00000263932_length(amino acids)=218AA_BP=68
MWHWHVAGGPGRVPPPQRSSMNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKQLRSGASVTEPVAEERGLMSQP
LMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHT

--------------------------------------------------------------
>66279_66279_6_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377748_TNFRSF8_chr1_12198286_ENST00000417814_length(transcript)=1678nt_BP=642nt
AAACTAAGGCCTTCCTGGTAGCCAAGGAGCCCAGCAGAGGGGCTGCTGCTGGCTGCTGGGATTGCAGAGGCCGGGGTCTCTGTGGTGTTG
CTTTCCTGGAAAGGAGGGACGGCACCTCCAGGGCAGCCAGCAGTGTGGGAGCCCATTCCAGGGCGCAAATGGGCACTCAGGAATGGAAAA
TCCAAGAAGGAACCAACCACCAACAAGGAAATGCAGTGTGAGCGGCGGCTGCGAAGTCTGTGCCTTCAAATATACAGCGCCCAGGGGACC
TGTGTTGGACGGGGAGCAAATTGGCAGGGCTGAGAGCGCCTTGGTTTTCTGTGCAGACAGGTCCAGCTGCAGAAATTAAGACTGGGGCTG
AGTCGGGGAGAAGCCTTCCATGTTGAGATGGCAACTGGGCAAAGCAGGACGGAGACCTGTGTGTCTGATTAGAGAGGCCTGTGGCATTGG
CATGTGGCTGGAGGTCCAGGCAGGGTGCCACCACCGCAGAGGTCAAGCATGAATTCAGTCCTGACAAAACATGGGTCTCCACCTCGAAGC
TGGCTCAGCCTTTGTTCAGGAACCGACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGG
CGGGCGGCCAAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCGGAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGC
CACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAG
CCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTACATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCT
GAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAGTTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAG
CAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCC
TCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCAGGGTGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTT
GGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAGTGGTGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTG
CATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCGGGGCTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAG
TGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCCGAGAACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCA
CCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCCGGGGCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGG
TGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAATGTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCC

>66279_66279_6_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000377748_TNFRSF8_chr1_12198286_ENST00000417814_length(amino acids)=217AA_BP=68
MWHWHVAGGPGRVPPPQRSSMNSVLTKHGSPPRSWLSLCSGTDDQSPAEKKGLRCQNPACMDKGRAAKLRSGASVTEPVAEERGLMSQPL
METCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTP

--------------------------------------------------------------
>66279_66279_7_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000400915_TNFRSF8_chr1_12198286_ENST00000263932_length(transcript)=2277nt_BP=148nt
CCCAGTCCCCGGCGTCCCCGGCGCCCCCGCCCGCCGCCCGCCCCCCGCGCGGCACGGGGCCTGCTCCATGGACGACCAGAGCCCCGCTGA
AAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGCAGCTGAGGAGTGGTGCGTCGGTGACAGAACC
CGTCGCGGAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCA
GGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAA
AATCTACATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCC
CGAGTTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCAT
GCTCTCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGC
AGCAGGGTGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCAT
CTAGTGGTGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGA
TCCGGGGCTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCAC
TGCCGAGAACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGC
TCCCGGGGCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGT
AAATGTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAGCTG
GCACTGTCTCTGCTGCAGCGGCCACACTGTACTCTGCACTGGTGTGAGGGCCCCTGCCTGGACTGTGGGACCCTCCTGGTGCTGCCCACC
TTCCCTGTCCTGTAGCCCCCTCGGTGGGCCCAGGGCCTAGGGCCCAGGATCAAGTCACTCATCTCAGAATGTCCCCACCAATCCCCGCCA
CAGCAGGCGCCTCGGGTCCCAGATGTCTGCAGCCCTCAGCAGCTGCAGACCGCCCCTCACCAACCCAGAGAACCTGCTTTACTTTGCCCA
GGGACTTCCTCCCCATGTGAACATGGGGAACTTCGGGCCCTGCCTGGAGTCCTTGACCGCTCTCTGTGGGCCCCACCCACTCTGTCCTGG
GAAATGAAGAAGCATCTTCCTTAGGTCTGCCCTGCTTGCAAATCCACTAGCACCGACCCCACCACCTGGTTCCGGCTCTGCACGCTTTGG
GGTGTGGATGTCGAGAGGCACCACGGCCTCACCCAGGCATCTGCTTTACTCTGGACCATAGGAAACAAGACCGTTTGGAGGTTTCATCAG
GATTTTGGGTTTTTCACATTTCACGCTAAGGAGTAGTGGCCCTGACTTCCGGTCGGCTGGCCAGCTGACTCCCTAGGGCCTTCAGACGTG
TATGCAAATGAGTGATGGATAAGGATGAGTCTTGGAGTTGCGGGCAGCCTGGAGACTCGTGGACTTACCGCCTGGAGGCAGGCCCGGGAA
GGCTGCTGTTTACTCATCGGGCAGCCACGTGCTCTCTGGAGGAAGTGATAGTTTCTGAAACCGCTCAGATGTTTTGGGGAAAGTTGGAGA
AGCCGTGGCCTTGCGAGAGGTGGTTACACCAGAACCTGGACATTGGCCAGAAGAAGCTTAAGTGGGCAGACACTGTTTGCCCAGTGTTTG
TGCAAGGATGGAGTGGGTGTCTCTGCATCACCCACAGCCGCAGCTGTAAGGCACGCTGGAAGGCACACGCCTGCCAGGCAGGGCAGTCTG
GCGCCCATGATGGGAGGGATTGACATGTTTCAACAAAATAATGCACTTCCTTACCTAGTGGCCCTTCACACAACTTTTGAATCTCTAAAA

>66279_66279_7_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000400915_TNFRSF8_chr1_12198286_ENST00000263932_length(amino acids)=177AA_BP=27
MDDQSPAEKKGLRCQNPACMDKGRAAKQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTE

--------------------------------------------------------------
>66279_66279_8_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000400915_TNFRSF8_chr1_12198286_ENST00000417814_length(transcript)=1184nt_BP=148nt
CCCAGTCCCCGGCGTCCCCGGCGCCCCCGCCCGCCGCCCGCCCCCCGCGCGGCACGGGGCCTGCTCCATGGACGACCAGAGCCCCGCTGA
AAAGAAGGGACTGCGCTGTCAGAACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGT
CGCGGAAGAGCGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGA
TGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAAT
CTACATCATGAAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGA
GTTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCT
CTCAGTGGAAGAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGC
AGGGTGGCCTCTGGGAGGCCAGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTA
GTGGTGGACCGGCCGGTCACTGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCC
GGGGCTTGTACAGAAGAGACAGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGC
CGAGAACAGCATTGGTCCCAGAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCC
CGGGGCCCCTGTAACCCTACTCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAA
TGTGGCCCCCAGTGGGCATGGAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAGCTGGCA

>66279_66279_8_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000400915_TNFRSF8_chr1_12198286_ENST00000417814_length(amino acids)=176AA_BP=27
MDDQSPAEKKGLRCQNPACMDKGRAAKLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEH

--------------------------------------------------------------
>66279_66279_9_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000537245_TNFRSF8_chr1_12198286_ENST00000263932_length(transcript)=2344nt_BP=215nt
ACCGCGGTGCACTCCAGCCCCCAGGAAGAGAGGCAGCTTGGAGGGGGCCAAATTCAGGGTCAAAGATGAGTCTTGGGGAACGGGGGTCGC
CCCAGACCTTCGGGGGCTCCTCTGTCTCTAAAGGGAGCGATGCAGGGCACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGA
ACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGCAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCGGAAGAGCGAGGGTTAA
TGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGATGCCAGCCCGGCCGGGGGCC
CCTCGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTACATCATGAAGGCTGACA
CCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAGTTGGAGGAGGAGCTGGAGG
CGGACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCAGTGGAAGAGGAAGGGA
AAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCAGGGTGGCCTCTGGGAGGCC
AGGATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAGTGGTGGACCGGCCGGTCAC
TGCAGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCGGGGCTTGTACAGAAGAGAC
AGTCCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCCGAGAACAGCATTGGTCCCA
GAGCCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCCGGGGCCCCTGTAACCCTAC
TCTCCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAATGTGGCCCCCAGTGGGCATG
GAGCCAGTGCCTGTGGTTGTTTCTCCAGAGTCAAAAGGGAAGTCGAGGGATGGGGCGTCGTCAGCTGGCACTGTCTCTGCTGCAGCGGCC
ACACTGTACTCTGCACTGGTGTGAGGGCCCCTGCCTGGACTGTGGGACCCTCCTGGTGCTGCCCACCTTCCCTGTCCTGTAGCCCCCTCG
GTGGGCCCAGGGCCTAGGGCCCAGGATCAAGTCACTCATCTCAGAATGTCCCCACCAATCCCCGCCACAGCAGGCGCCTCGGGTCCCAGA
TGTCTGCAGCCCTCAGCAGCTGCAGACCGCCCCTCACCAACCCAGAGAACCTGCTTTACTTTGCCCAGGGACTTCCTCCCCATGTGAACA
TGGGGAACTTCGGGCCCTGCCTGGAGTCCTTGACCGCTCTCTGTGGGCCCCACCCACTCTGTCCTGGGAAATGAAGAAGCATCTTCCTTA
GGTCTGCCCTGCTTGCAAATCCACTAGCACCGACCCCACCACCTGGTTCCGGCTCTGCACGCTTTGGGGTGTGGATGTCGAGAGGCACCA
CGGCCTCACCCAGGCATCTGCTTTACTCTGGACCATAGGAAACAAGACCGTTTGGAGGTTTCATCAGGATTTTGGGTTTTTCACATTTCA
CGCTAAGGAGTAGTGGCCCTGACTTCCGGTCGGCTGGCCAGCTGACTCCCTAGGGCCTTCAGACGTGTATGCAAATGAGTGATGGATAAG
GATGAGTCTTGGAGTTGCGGGCAGCCTGGAGACTCGTGGACTTACCGCCTGGAGGCAGGCCCGGGAAGGCTGCTGTTTACTCATCGGGCA
GCCACGTGCTCTCTGGAGGAAGTGATAGTTTCTGAAACCGCTCAGATGTTTTGGGGAAAGTTGGAGAAGCCGTGGCCTTGCGAGAGGTGG
TTACACCAGAACCTGGACATTGGCCAGAAGAAGCTTAAGTGGGCAGACACTGTTTGCCCAGTGTTTGTGCAAGGATGGAGTGGGTGTCTC
TGCATCACCCACAGCCGCAGCTGTAAGGCACGCTGGAAGGCACACGCCTGCCAGGCAGGGCAGTCTGGCGCCCATGATGGGAGGGATTGA
CATGTTTCAACAAAATAATGCACTTCCTTACCTAGTGGCCCTTCACACAACTTTTGAATCTCTAAAAATCCATAAAATCCTTAAAGAACT

>66279_66279_9_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000537245_TNFRSF8_chr1_12198286_ENST00000263932_length(amino acids)=200AA_BP=50
MSLGERGSPQTFGGSSVSKGSDAGHDQSPAEKKGLRCQNPACMDKGRAAKQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPL
QDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDV

--------------------------------------------------------------
>66279_66279_10_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000537245_TNFRSF8_chr1_12198286_ENST00000417814_length(transcript)=1251nt_BP=215nt
ACCGCGGTGCACTCCAGCCCCCAGGAAGAGAGGCAGCTTGGAGGGGGCCAAATTCAGGGTCAAAGATGAGTCTTGGGGAACGGGGGTCGC
CCCAGACCTTCGGGGGCTCCTCTGTCTCTAAAGGGAGCGATGCAGGGCACGACCAGAGCCCCGCTGAAAAGAAGGGACTGCGCTGTCAGA
ACCCCGCCTGCATGGACAAGGGGCGGGCGGCCAAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCGGAAGAGCGAGGGTTAATGA
GCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTGGAGAGCCTGCCGCTGCAGGATGCCAGCCCGGCCGGGGGCCCCT
CGTCCCCCAGGGACCTTCCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTACATCATGAAGGCTGACACCG
TGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTGGCGGGGCCAGCAGAGCCCGAGTTGGAGGAGGAGCTGGAGGCGG
ACCATACCCCCCACTACCCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCAGTGGAAGAGGAAGGGAAAG
AAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGAGGCCTGGGCTGGGCTGGGGCTAGGAGGGCAGCAGGGTGGCCTCTGGGAGGCCAGG
ATGGCACTGTTGGCACCGAGGTTGGGGGCAGAGGCCCATCTGGCCTGAACTGAGGCTCCAGCATCTAGTGGTGGACCGGCCGGTCACTGC
AGGGGTCTGGTGGTCTCTGCTTGCATCCCCAACTTAGCTGTCCCCTGACCCAGAGCCTAGGGGATCCGGGGCTTGTACAGAAGAGACAGT
CCAAGGGGACTGGATCCCAGCAGTGATGTTGGTTGAGGCAGCAAACAGATGGCAGGATGGGCACTGCCGAGAACAGCATTGGTCCCAGAG
CCCTGGGCATCAGACCTTAACCACCAGGCCCACAGCCCAGCGAGGGAGAGGTCGTGAGGCCAGCTCCCGGGGCCCCTGTAACCCTACTCT
CCTCTCTCCCTGGACCTCAGAGGTGACACCCATTGGGCCCTTCCGGCATGCCCCCAGTTACTGTAAATGTGGCCCCCAGTGGGCATGGAG

>66279_66279_10_PLEKHG5-TNFRSF8_PLEKHG5_chr1_6556553_ENST00000537245_TNFRSF8_chr1_12198286_ENST00000417814_length(amino acids)=199AA_BP=50
MSLGERGSPQTFGGSSVSKGSDAGHDQSPAEKKGLRCQNPACMDKGRAAKLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQ
DASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PLEKHG5-TNFRSF8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PLEKHG5-TNFRSF8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PLEKHG5-TNFRSF8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PLEKHG5	C3809309	CHARCOT-MARIE-TOOTH DISEASE, RECESSIVE INTERMEDIATE C	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	PLEKHG5	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Hgene	PLEKHG5	C0393541	Distal Spinal Muscular Atrophy	1	GENOMICS_ENGLAND
Hgene	PLEKHG5	C1136382	Sclerocystic Ovaries	1	CTD_human
Hgene	PLEKHG5	C1970211	Spinal Muscular Atrophy, Distal, Autosomal Recessive, 4	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0019829	Hodgkin Disease	2	CTD_human
Tgene		C0152266	Mixed Cellularity Hodgkin Lymphoma	2	CTD_human
Tgene		C0152267	Hodgkin lymphoma, lymphocyte depletion	2	CTD_human
Tgene		C0220597	Adult Hodgkin Lymphoma	2	CTD_human
Tgene		C1266194	Lymphocyte Rich Classical Hodgkin Lymphoma	2	CTD_human
Tgene		C1334968	Nodular Lymphocyte Predominant Hodgkin Lymphoma	2	CTD_human
Tgene		C0345967	Malignant mesothelioma	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:PLEKHG5-TNFRSF8 (FusionGDB2 ID:HG57449TG943)

Fusion Gene Summary for PLEKHG5-TNFRSF8

Fusion Gene ORF analysis for PLEKHG5-TNFRSF8

Fusion Genomic Features for PLEKHG5-TNFRSF8

Fusion Protein Features for PLEKHG5-TNFRSF8

Fusion Gene Sequence for PLEKHG5-TNFRSF8

Fusion Gene PPI Analysis for PLEKHG5-TNFRSF8

Related Drugs for PLEKHG5-TNFRSF8

Related Diseases for PLEKHG5-TNFRSF8

Fusion Gene Studies
in Kim Lab