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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TAOK1-PIPOX (FusionGDB2 ID:HG57551TG51268)

Fusion Gene Summary for TAOK1-PIPOX

check button Fusion gene summary
Fusion gene informationFusion gene name: TAOK1-PIPOX
Fusion gene ID: hg57551tg51268
HgeneTgene
Gene symbol

TAOK1

PIPOX

Gene ID

57551

51268

Gene nameTAO kinase 1pipecolic acid and sarcosine oxidase
SynonymsKFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1LPIPOX
Cytomap('TAOK1')('PIPOX')

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kinperoxisomal sarcosine oxidaseL-pipecolate oxidaseL-pipecolic acid oxidasePSOpipecolic acid oxidase
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261716, ENST00000536202, 
Fusion gene scores* DoF score42 X 23 X 20=193209 X 8 X 5=360
# samples 5212
** MAII scorelog2(52/19320*10)=-5.21543966069468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAOK1 [Title/Abstract] AND PIPOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTAOK1(27718042)-PIPOX(27371876), # samples:1
TAOK1(27838010)-PIPOX(27371877), # samples:1
TAOK1(27718042)-PIPOX(27371877), # samples:1
TAOK1(27718042)-PIPOX(27367701), # samples:1
TAOK1(27794234)-PIPOX(27371877), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAOK1

GO:0006974

cellular response to DNA damage stimulus

17396146

HgeneTAOK1

GO:0016310

phosphorylation

12639963

HgeneTAOK1

GO:0046330

positive regulation of JNK cascade

16407310

HgeneTAOK1

GO:0097194

execution phase of apoptosis

16407310

TgenePIPOX

GO:0033514

L-lysine catabolic process to acetyl-CoA via L-pipecolate

10642506

TgenePIPOX

GO:0055114

oxidation-reduction process

10642506



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A18G-01ATAOK1chr17

27794234

-PIPOXchr17

27371877

+
ChimerDB4STADTCGA-MX-A666-01ATAOK1chr17

27838010

+PIPOXchr17

27371877

+
ChimerDB4UCECTCGA-FI-A2EU-01ATAOK1chr17

27718042

+PIPOXchr17

27367701

+
ChimerDB4UCECTCGA-FI-A2EU-01ATAOK1chr17

27718042

+PIPOXchr17

27371877

+
ChimerDB4UCECTCGA-FI-A2EUTAOK1chr17

27718042

+PIPOXchr17

27371876

+


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Fusion Gene ORF analysis for TAOK1-PIPOX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000261716ENST00000323372TAOK1chr17

27794234

-PIPOXchr17

27371877

+
5CDS-3UTRENST00000261716ENST00000323372TAOK1chr17

27838010

+PIPOXchr17

27371877

+
5CDS-3UTRENST00000261716ENST00000583215TAOK1chr17

27794234

-PIPOXchr17

27371877

+
5CDS-3UTRENST00000261716ENST00000583215TAOK1chr17

27838010

+PIPOXchr17

27371877

+
5CDS-3UTRENST00000536202ENST00000323372TAOK1chr17

27794234

-PIPOXchr17

27371877

+
5CDS-3UTRENST00000536202ENST00000323372TAOK1chr17

27838010

+PIPOXchr17

27371877

+
5CDS-3UTRENST00000536202ENST00000583215TAOK1chr17

27794234

-PIPOXchr17

27371877

+
5CDS-3UTRENST00000536202ENST00000583215TAOK1chr17

27838010

+PIPOXchr17

27371877

+
5UTR-3UTRENST00000261716ENST00000323372TAOK1chr17

27718042

+PIPOXchr17

27371877

+
5UTR-3UTRENST00000261716ENST00000323372TAOK1chr17

27718042

+PIPOXchr17

27371876

+
5UTR-3UTRENST00000261716ENST00000583215TAOK1chr17

27718042

+PIPOXchr17

27367701

+
5UTR-3UTRENST00000261716ENST00000583215TAOK1chr17

27718042

+PIPOXchr17

27371877

+
5UTR-3UTRENST00000261716ENST00000583215TAOK1chr17

27718042

+PIPOXchr17

27371876

+
5UTR-3UTRENST00000536202ENST00000323372TAOK1chr17

27718042

+PIPOXchr17

27371877

+
5UTR-3UTRENST00000536202ENST00000323372TAOK1chr17

27718042

+PIPOXchr17

27371876

+
5UTR-3UTRENST00000536202ENST00000583215TAOK1chr17

27718042

+PIPOXchr17

27367701

+
5UTR-3UTRENST00000536202ENST00000583215TAOK1chr17

27718042

+PIPOXchr17

27371877

+
5UTR-3UTRENST00000536202ENST00000583215TAOK1chr17

27718042

+PIPOXchr17

27371876

+
5UTR-intronENST00000261716ENST00000323372TAOK1chr17

27718042

+PIPOXchr17

27367701

+
5UTR-intronENST00000536202ENST00000323372TAOK1chr17

27718042

+PIPOXchr17

27367701

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TAOK1-PIPOX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TAOK1chr1727838010+PIPOXchr1727371876+1.79E-060.9999982
TAOK1chr1727718042+PIPOXchr1727371876+5.86E-091
TAOK1chr1727718042+PIPOXchr1727371876+5.86E-091
TAOK1chr1727718042+PIPOXchr1727367700+4.68E-091
TAOK1chr1727838010+PIPOXchr1727371876+1.79E-060.9999982
TAOK1chr1727718042+PIPOXchr1727371876+5.86E-091
TAOK1chr1727718042+PIPOXchr1727371876+5.86E-091
TAOK1chr1727718042+PIPOXchr1727367700+4.68E-091


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TAOK1-PIPOX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27718042/:27371876)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TAOK1-PIPOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TAOK1-PIPOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TAOK1-PIPOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TAOK1-PIPOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAOK1C0018781Noise-induced hearing loss1CTD_human
HgeneTAOK1C0424605Developmental delay (disorder)1GENOMICS_ENGLAND
HgeneTAOK1C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneTAOK1C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneTAOK1C4225275MENTAL RETARDATION, AUTOSOMAL DOMINANT 401GENOMICS_ENGLAND
TgeneC0282525Adrenoleukodystrophy, Neonatal1CTD_human
TgeneC0282526Hyperpipecolic Acidemia1CTD_human
TgeneC0282528Peroxisomal Disorders1CTD_human
TgeneC0751708Peroxisomal Dysfunction, General1CTD_human
TgeneC0751709Peroxisomal Dysfunction, Multiple1CTD_human
TgeneC0751710Peroxisomal Dysfunction, Single1CTD_human