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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP23-ASIC2 (FusionGDB2 ID:HG57636TG40)

Fusion Gene Summary for ARHGAP23-ASIC2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP23-ASIC2
Fusion gene ID: hg57636tg40
HgeneTgene
Gene symbol

ARHGAP23

ASIC2

Gene ID

57636

40

Gene nameRho GTPase activating protein 23acid sensing ion channel subunit 2
Synonyms-ACCN|ACCN1|ASIC2a|BNC1|BNaC1|MDEG|hBNaC1
Cytomap('ARHGAP23','ARHGAP23')('ACCN1','ASIC2')

17q12

17q11.2-q12

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 23rho-type GTPase-activating protein 23acid-sensing ion channel 2acid sensing (proton gated) ion channel 2amiloride-sensitive cation channel 1, neuronalbrain sodium channel 1mammalian degenerin homologneuronal amiloride-sensitive cation channel 1
Modification date2020031320200313
UniProtAcc.

Q16515

Ensembl transtripts involved in fusion geneENST00000431231, ENST00000437668, 
ENST00000443378, ENST00000582409, 
Fusion gene scores* DoF score13 X 12 X 10=156018 X 14 X 7=1764
# samples 1419
** MAII scorelog2(14/1560*10)=-3.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1764*10)=-3.21477923722657
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP23 [Title/Abstract] AND ASIC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP23(36636124)-ASIC2(31351032), # samples:3
ARHGAP23(36636124)-ACCN1(31351032), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGAP23-ASIC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP23-ASIC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP23-ASIC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP23-ASIC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ASIC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TX-01AARHGAP23chr17

36636124

-ACCN1chr17

31351032

-
ChimerDB4BRCATCGA-AR-A0TX-01AARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
ChimerDB4BRCATCGA-AR-A0TXARHGAP23chr17

36636124

+ASIC2chr17

31351032

-


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Fusion Gene ORF analysis for ARHGAP23-ASIC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000431231ENST00000448983ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
5CDS-5UTRENST00000437668ENST00000448983ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
5CDS-5UTRENST00000443378ENST00000448983ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
In-frameENST00000431231ENST00000225823ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
In-frameENST00000431231ENST00000359872ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
In-frameENST00000437668ENST00000225823ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
In-frameENST00000437668ENST00000359872ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
In-frameENST00000443378ENST00000225823ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
In-frameENST00000443378ENST00000359872ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
intron-3CDSENST00000582409ENST00000225823ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
intron-3CDSENST00000582409ENST00000359872ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-
intron-5UTRENST00000582409ENST00000448983ARHGAP23chr17

36636124

+ASIC2chr17

31351032

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000431231ARHGAP23chr1736636124+ENST00000225823ASIC2chr1731351032-407226971731931058
ENST00000431231ARHGAP23chr1736636124+ENST00000359872ASIC2chr1731351032-407226971731931058
ENST00000437668ARHGAP23chr1736636124+ENST00000225823ASIC2chr1731351032-40042629031251041
ENST00000437668ARHGAP23chr1736636124+ENST00000359872ASIC2chr1731351032-40042629031251041
ENST00000443378ARHGAP23chr1736636124+ENST00000225823ASIC2chr1731351032-4384300942535051026
ENST00000443378ARHGAP23chr1736636124+ENST00000359872ASIC2chr1731351032-4384300942535051026

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000431231ENST00000225823ARHGAP23chr1736636124+ASIC2chr1731351032-0.002958690.9970413
ENST00000431231ENST00000359872ARHGAP23chr1736636124+ASIC2chr1731351032-0.002958690.9970413
ENST00000437668ENST00000225823ARHGAP23chr1736636124+ASIC2chr1731351032-0.0026506510.9973494
ENST00000437668ENST00000359872ARHGAP23chr1736636124+ASIC2chr1731351032-0.0026506510.9973494
ENST00000443378ENST00000225823ARHGAP23chr1736636124+ASIC2chr1731351032-0.0032495110.9967505
ENST00000443378ENST00000359872ARHGAP23chr1736636124+ASIC2chr1731351032-0.0032495110.9967505

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Fusion Genomic Features for ARHGAP23-ASIC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARHGAP23-ASIC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:36636124/chr17:31351032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASIC2

Q16515

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000431231+1424183_2798761492.0Compositional biasNote=Pro-rich
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000437668+1425183_2798761145.0Compositional biasNote=Pro-rich
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000431231+1424688_8088761492.0DomainPH
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000431231+142471_1558761492.0DomainPDZ
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000437668+1425688_8088761145.0DomainPH
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000437668+142571_1558761145.0DomainPDZ
TgeneASIC2chr17:36636124chr17:31351032ENST00000225823410449_512398564.0Topological domainCytoplasmic
TgeneASIC2chr17:36636124chr17:31351032ENST00000359872410449_512347513.0Topological domainCytoplasmic
TgeneASIC2chr17:36636124chr17:31351032ENST00000225823410428_448398564.0TransmembraneHelical
TgeneASIC2chr17:36636124chr17:31351032ENST00000359872410428_448347513.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000431231+14241320_14058761492.0Compositional biasNote=Arg-rich
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000437668+14251320_14058761145.0Compositional biasNote=Arg-rich
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000431231+1424905_10978761492.0DomainRho-GAP
HgeneARHGAP23chr17:36636124chr17:31351032ENST00000437668+1425905_10978761145.0DomainRho-GAP
TgeneASIC2chr17:36636124chr17:31351032ENST000002258234101_37398564.0Topological domainCytoplasmic
TgeneASIC2chr17:36636124chr17:31351032ENST0000022582341059_427398564.0Topological domainExtracellular
TgeneASIC2chr17:36636124chr17:31351032ENST000003598724101_37347513.0Topological domainCytoplasmic
TgeneASIC2chr17:36636124chr17:31351032ENST0000035987241059_427347513.0Topological domainExtracellular
TgeneASIC2chr17:36636124chr17:31351032ENST0000022582341038_58398564.0TransmembraneHelical
TgeneASIC2chr17:36636124chr17:31351032ENST0000035987241038_58347513.0TransmembraneHelical


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Fusion Gene Sequence for ARHGAP23-ASIC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5998_5998_1_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000431231_ASIC2_chr17_31351032_ENST00000225823_length(transcript)=4072nt_BP=2697nt
CCGCCCCTCCCGGGTCCCTGCCGGCGCCCCCAGCCGTGCCCCGGCCGCAGAGCCGCCGCTGCCACCCGATGAATGGAGTCGCCTTCTGCC
TGGTCGGGATCCCGCCCCGCCCGGAGCCCCGGCCCCCACAGCTGCCACTGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCT
GGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCTTTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGT
CGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAGGAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCA
TCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGCTTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCG
TCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTGATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACA
TCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGCCGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGA
TCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCAGGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTG
ACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCACCTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGA
GCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGCCCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGC
CCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAAACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCA
TGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGGCTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTT
TGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACTACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAG
GGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGCGTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGC
CAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACCTCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGC
GCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTGGGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCAT
TCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCAGCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATG
AGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGACCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCC
CAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGGCCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCT
TTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACGTCCCTGCCTCTGCTGTGGTCTCCAGTGCCATGAACTCAGCCC
CTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCGGACGCCATTACTCGCAGGACTGCAGCAGCATCAAGGCTGGCC
GCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCTGCGATGATGGACTCAACACCTTCCGCGACGAGGGCCGGGTTC
TGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCTTCTTCACCGACGGGTCCTTGGATAGCTGGGGCACCTCTGAAG
ATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATGCGACCTTCAGCGATATCAGGAGAGAAGGCTGGTTGTATTATA
AGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCCAGTGGAAGCGGGTGTACGCCGCGCTGCGGGCGCGCTCGCTCT
CGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTGCGGCGGCCGGCGCAGGTGAGGACGAGGCGGCGCCCGTCTGCA
TCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGCACGTGTTCCGGCTGACCACCGCTGACTTCTGTGAATATCTCT
TTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCCGGGAGAACAGCAGGGCCGAGGGCGAGGACCCCGGCTGTGCCA
ACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCCATAGCTCTGGGCCCAAAGCTGATTCCTCCCCCAAAGGCTCTC
GCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCACGTGGCCTCAGGACTCAGGACCTGCCCGCAGGGAGCAAGGGTC
TGTTGGCGGAAAAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCC
CCAGCAAGACATCAGCCAAGTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAGAACATCCTTGTTCTGGATATATTTT
TTGAAGCTCTCAATTATGAGACAATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGT
TCATTGGTGCTAGTATCCTTACAATACTAGAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAG
AGGAGGACGAAGGGAGCCACGATGAGAATGTGAGTACTTGTGACACAATGCCAAACCACTCTGAAACCATCAGTCACACTGTGAACGTGC
CCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGCTGACACCCCTCGAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCC
CAAGACCCAGGACAAGGAACAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGGAAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTA
GCTGCCTAGACCTCGCTCCGGCCACGTCCAACACGACGCATCCTTGGGCCCCGCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTG
GAACTGTCCAAGAACGAACCTGCCATCACATCTCACTGCCAGATGTATAAAGCACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCAC
GTCTGTCTTGTACATGACACTCCTCCACGCGGTTTCCAGTGTCCACACTGCTGCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCAC
CATGAGGCCACCCTGGAATCAGAACTGCACAATCAAGAGGGAACCCATGGGACTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAG
TTCTTAACCTGCCCAAAAACCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCGGCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCA
GTGCCTATGACGGCGGCACAGCAGCCAGCGGGTGGGGGACGCCTGTGTTCACCCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACA
GCTTGTACAGTCTGATTCTTTTTATCTGGGGTAGGGGGGCTTTTATGTTTGTCCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCT
TTTTTATTTTAGTTTTGATGTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCTTTGGCATTTATTTATTCGTGCTTCAAATCACAGTCATA

>5998_5998_1_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000431231_ASIC2_chr17_31351032_ENST00000225823_length(amino acids)=1058AA_BP=893
MPAPPAVPRPQSRRCHPMNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCS
LKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAY
SQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPS
PGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQ
EGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLL
HALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEAS
GRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYL
LAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTK
KGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDR
DDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKGLLAEKD
SNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASI

--------------------------------------------------------------
>5998_5998_2_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000431231_ASIC2_chr17_31351032_ENST00000359872_length(transcript)=4072nt_BP=2697nt
CCGCCCCTCCCGGGTCCCTGCCGGCGCCCCCAGCCGTGCCCCGGCCGCAGAGCCGCCGCTGCCACCCGATGAATGGAGTCGCCTTCTGCC
TGGTCGGGATCCCGCCCCGCCCGGAGCCCCGGCCCCCACAGCTGCCACTGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCT
GGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCTTTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGT
CGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAGGAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCA
TCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGCTTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCG
TCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTGATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACA
TCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGCCGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGA
TCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCAGGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTG
ACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCACCTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGA
GCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGCCCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGC
CCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAAACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCA
TGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGGCTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTT
TGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACTACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAG
GGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGCGTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGC
CAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACCTCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGC
GCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTGGGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCAT
TCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCAGCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATG
AGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGACCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCC
CAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGGCCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCT
TTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACGTCCCTGCCTCTGCTGTGGTCTCCAGTGCCATGAACTCAGCCC
CTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCGGACGCCATTACTCGCAGGACTGCAGCAGCATCAAGGCTGGCC
GCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCTGCGATGATGGACTCAACACCTTCCGCGACGAGGGCCGGGTTC
TGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCTTCTTCACCGACGGGTCCTTGGATAGCTGGGGCACCTCTGAAG
ATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATGCGACCTTCAGCGATATCAGGAGAGAAGGCTGGTTGTATTATA
AGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCCAGTGGAAGCGGGTGTACGCCGCGCTGCGGGCGCGCTCGCTCT
CGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTGCGGCGGCCGGCGCAGGTGAGGACGAGGCGGCGCCCGTCTGCA
TCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGCACGTGTTCCGGCTGACCACCGCTGACTTCTGTGAATATCTCT
TTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCCGGGAGAACAGCAGGGCCGAGGGCGAGGACCCCGGCTGTGCCA
ACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCCATAGCTCTGGGCCCAAAGCTGATTCCTCCCCCAAAGGCTCTC
GCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCACGTGGCCTCAGGACTCAGGACCTGCCCGCAGGGAGCAAGGGTC
TGTTGGCGGAAAAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCC
CCAGCAAGACATCAGCCAAGTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAGAACATCCTTGTTCTGGATATATTTT
TTGAAGCTCTCAATTATGAGACAATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGT
TCATTGGTGCTAGTATCCTTACAATACTAGAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAG
AGGAGGACGAAGGGAGCCACGATGAGAATGTGAGTACTTGTGACACAATGCCAAACCACTCTGAAACCATCAGTCACACTGTGAACGTGC
CCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGCTGACACCCCTCGAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCC
CAAGACCCAGGACAAGGAACAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGGAAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTA
GCTGCCTAGACCTCGCTCCGGCCACGTCCAACACGACGCATCCTTGGGCCCCGCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTG
GAACTGTCCAAGAACGAACCTGCCATCACATCTCACTGCCAGATGTATAAAGCACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCAC
GTCTGTCTTGTACATGACACTCCTCCACGCGGTTTCCAGTGTCCACACTGCTGCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCAC
CATGAGGCCACCCTGGAATCAGAACTGCACAATCAAGAGGGAACCCATGGGACTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAG
TTCTTAACCTGCCCAAAAACCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCGGCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCA
GTGCCTATGACGGCGGCACAGCAGCCAGCGGGTGGGGGACGCCTGTGTTCACCCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACA
GCTTGTACAGTCTGATTCTTTTTATCTGGGGTAGGGGGGCTTTTATGTTTGTCCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCT
TTTTTATTTTAGTTTTGATGTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCTTTGGCATTTATTTATTCGTGCTTCAAATCACAGTCATA

>5998_5998_2_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000431231_ASIC2_chr17_31351032_ENST00000359872_length(amino acids)=1058AA_BP=893
MPAPPAVPRPQSRRCHPMNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCS
LKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAY
SQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPS
PGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQ
EGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLL
HALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEAS
GRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYL
LAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTK
KGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDR
DDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKGLLAEKD
SNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASI

--------------------------------------------------------------
>5998_5998_3_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000437668_ASIC2_chr17_31351032_ENST00000225823_length(transcript)=4004nt_BP=2629nt
ATGAATGGAGTCGCCTTCTGCCTGGTCGGGATCCCGCCCCGCCCGGAGCCCCGGCCCCCACAGCTGCCACTGGGCCCAAGAGATGGGTGC
TCTCCTAGGCGCCCCTTCCCCTGGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCTTTGGCTTCACTCTGCGCCAC
TTCATCGTGTACCCACCCGAGTCGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAGGAGGACCCTCCCCCCGGTAC
CGCCTGGAGCCCATGGACACCATCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGCTTCGCACAGGAGACCGGCTG
GTAAAGGTGAATGGGGAAAGCGTCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTGATGACACTCTGGAGCTGTCT
ATCATGCCCAAGGACGAGGACATCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGCCGTATTCTGGAGAGGCCCGC
AGCATCCCAGAGCCACCGCCGATCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCAGGGCCACTATGGTGCCTGAG
CCCACCTCAGCACTGCCCAGTGACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCACCTGCTGCCCGTGCCCACCTG
GACAACTCTTCCTTGGGGATGAGCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGCCCCGGACGCCCCGTGCCTTC
CCAGAGCCTGGCAGCCGGGTGCCCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAAACCAGGTACCCCGCCGGGCG
GGGGAGAGACGGTGCCCAGCCATGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGGCTGCCCCCCGCCCGTGGCCC
TGCTCCACCTCCCAGGATGCTTTGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACTACTTGAGCCGGGCCACCCGT
TCTGCCGAGGCACTGGGGCCAGGGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGCGTTCGTCTGCCCGCACCCCC
GCCTGCCCAACTCGGGACCTGCCAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACCTCGGGTACATCGGCTACCGG
AGCTACAGCCCATCATTCCAGCGCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTGGGGGGCTGCCTACCTTCAAC
CTGGCCCAGTCCCCTGCGTCATTCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCAGCACCCGGGCCCTGGAGCCT
CCTGCGGAGGATCGCGGCGATGAGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGACCCCCGCAAGACAGATGAAC
CTTGGATTTGGTGACGAGTCCCCAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGGCCCCTTTGGCCACCACCGAA
GACTCTCTGGCTTCCATCCCCTTTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACGTCCCTGCCTCTGCTGTGGTC
TCCAGTGCCATGAACTCAGCCCCTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCGGACGCCATTACTCGCAGGAC
TGCAGCAGCATCAAGGCTGGCCGCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCTGCGATGATGGACTCAACACC
TTCCGCGACGAGGGCCGGGTTCTGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCTTCTTCACCGACGGGTCCTTG
GATAGCTGGGGCACCTCTGAAGATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATGCGACCTTCAGCGATATCAGG
AGAGAAGGCTGGTTGTATTATAAGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCCAGTGGAAGCGGGTGTACGCC
GCGCTGCGGGCGCGCTCGCTCTCGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTGCGGCGGCCGGCGCAGGTGAG
GACGAGGCGGCGCCCGTCTGCATCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGCACGTGTTCCGGCTGACCACC
GCTGACTTCTGTGAATATCTCTTTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCCGGGAGAACAGCAGGGCCGAG
GGCGAGGACCCCGGCTGTGCCAACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCCATAGCTCTGGGCCCAAAGCT
GATTCCTCCCCCAAAGGCTCTCGCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCACGTGGCCTCAGGACTCAGGAC
CTGCCCGCAGGGAGCAAGGGTCTGTTGGCGGAAAAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGCTACAACAAA
GAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAAGTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAGAAC
ATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGAGACAATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGAT
ATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCTTACAATACTAGAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAG
CTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCACGATGAGAATGTGAGTACTTGTGACACAATGCCAAACCACTCTGAAACC
ATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGCTGACACCCCTCGAGTCACCCAGCACTC
CCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAACAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGGAAAGAAGCAAGAGCCC
CCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCCGGCCACGTCCAACACGACGCATCCTTGGGCCCCGCCGTGCGTCCCTCTT
AGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAACCTGCCATCACATCTCACTGCCAGATGTATAAAGCACCTGCATGCTCAGA
CTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACACTCCTCCACGCGGTTTCCAGTGTCCACACTGCTGCCCGTGCAGTGGGAC
CAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAATCAGAACTGCACAATCAAGAGGGAACCCATGGGACTCTCTGCTACATTCA
GTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAACCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCGGCGCCAAAGGTGACCC
GCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCACAGCAGCCAGCGGGTGGGGGACGCCTGTGTTCACCCATGGTGCCCATGTC
GTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCTTTTTATCTGGGGTAGGGGGGCTTTTATGTTTGTCCGATGGAGATTTGTT
TTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGATGTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCTTTGGCATTTATTTATT

>5998_5998_3_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000437668_ASIC2_chr17_31351032_ENST00000225823_length(amino acids)=1041AA_BP=876
MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRY
RLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR
SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAF
PEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR
SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFN
LAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE
DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNT
FRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA
ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAE
GEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKGLLAEKDSNYCLCRTPCNLTRYNK
ELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEK

--------------------------------------------------------------
>5998_5998_4_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000437668_ASIC2_chr17_31351032_ENST00000359872_length(transcript)=4004nt_BP=2629nt
ATGAATGGAGTCGCCTTCTGCCTGGTCGGGATCCCGCCCCGCCCGGAGCCCCGGCCCCCACAGCTGCCACTGGGCCCAAGAGATGGGTGC
TCTCCTAGGCGCCCCTTCCCCTGGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCTTTGGCTTCACTCTGCGCCAC
TTCATCGTGTACCCACCCGAGTCGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAGGAGGACCCTCCCCCCGGTAC
CGCCTGGAGCCCATGGACACCATCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGCTTCGCACAGGAGACCGGCTG
GTAAAGGTGAATGGGGAAAGCGTCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTGATGACACTCTGGAGCTGTCT
ATCATGCCCAAGGACGAGGACATCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGCCGTATTCTGGAGAGGCCCGC
AGCATCCCAGAGCCACCGCCGATCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCAGGGCCACTATGGTGCCTGAG
CCCACCTCAGCACTGCCCAGTGACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCACCTGCTGCCCGTGCCCACCTG
GACAACTCTTCCTTGGGGATGAGCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGCCCCGGACGCCCCGTGCCTTC
CCAGAGCCTGGCAGCCGGGTGCCCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAAACCAGGTACCCCGCCGGGCG
GGGGAGAGACGGTGCCCAGCCATGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGGCTGCCCCCCGCCCGTGGCCC
TGCTCCACCTCCCAGGATGCTTTGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACTACTTGAGCCGGGCCACCCGT
TCTGCCGAGGCACTGGGGCCAGGGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGCGTTCGTCTGCCCGCACCCCC
GCCTGCCCAACTCGGGACCTGCCAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACCTCGGGTACATCGGCTACCGG
AGCTACAGCCCATCATTCCAGCGCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTGGGGGGCTGCCTACCTTCAAC
CTGGCCCAGTCCCCTGCGTCATTCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCAGCACCCGGGCCCTGGAGCCT
CCTGCGGAGGATCGCGGCGATGAGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGACCCCCGCAAGACAGATGAAC
CTTGGATTTGGTGACGAGTCCCCAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGGCCCCTTTGGCCACCACCGAA
GACTCTCTGGCTTCCATCCCCTTTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACGTCCCTGCCTCTGCTGTGGTC
TCCAGTGCCATGAACTCAGCCCCTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCGGACGCCATTACTCGCAGGAC
TGCAGCAGCATCAAGGCTGGCCGCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCTGCGATGATGGACTCAACACC
TTCCGCGACGAGGGCCGGGTTCTGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCTTCTTCACCGACGGGTCCTTG
GATAGCTGGGGCACCTCTGAAGATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATGCGACCTTCAGCGATATCAGG
AGAGAAGGCTGGTTGTATTATAAGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCCAGTGGAAGCGGGTGTACGCC
GCGCTGCGGGCGCGCTCGCTCTCGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTGCGGCGGCCGGCGCAGGTGAG
GACGAGGCGGCGCCCGTCTGCATCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGCACGTGTTCCGGCTGACCACC
GCTGACTTCTGTGAATATCTCTTTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCCGGGAGAACAGCAGGGCCGAG
GGCGAGGACCCCGGCTGTGCCAACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCCATAGCTCTGGGCCCAAAGCT
GATTCCTCCCCCAAAGGCTCTCGCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCACGTGGCCTCAGGACTCAGGAC
CTGCCCGCAGGGAGCAAGGGTCTGTTGGCGGAAAAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGCTACAACAAA
GAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAAGTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAGAAC
ATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGAGACAATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGAT
ATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCTTACAATACTAGAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAG
CTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCACGATGAGAATGTGAGTACTTGTGACACAATGCCAAACCACTCTGAAACC
ATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGCTGACACCCCTCGAGTCACCCAGCACTC
CCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAACAGCAAGCTCAGGTGGGATGGCCCCAGTGCTGGAAAGAAGCAAGAGCCC
CCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCCGGCCACGTCCAACACGACGCATCCTTGGGCCCCGCCGTGCGTCCCTCTT
AGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAACCTGCCATCACATCTCACTGCCAGATGTATAAAGCACCTGCATGCTCAGA
CTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACACTCCTCCACGCGGTTTCCAGTGTCCACACTGCTGCCCGTGCAGTGGGAC
CAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAATCAGAACTGCACAATCAAGAGGGAACCCATGGGACTCTCTGCTACATTCA
GTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAACCCCCTTTTCCCCAAGCTGCCCATGGGGCTTCGGCGCCAAAGGTGACCC
GCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCACAGCAGCCAGCGGGTGGGGGACGCCTGTGTTCACCCATGGTGCCCATGTC
GTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCTTTTTATCTGGGGTAGGGGGGCTTTTATGTTTGTCCGATGGAGATTTGTT
TTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGATGTTCTGAGGTTTGCTTTGGTTTTTCCATTTTCTTTGGCATTTATTTATT

>5998_5998_4_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000437668_ASIC2_chr17_31351032_ENST00000359872_length(amino acids)=1041AA_BP=876
MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRY
RLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR
SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAF
PEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR
SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFN
LAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE
DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNT
FRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA
ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAE
GEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKGLLAEKDSNYCLCRTPCNLTRYNK
ELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEK

--------------------------------------------------------------
>5998_5998_5_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000443378_ASIC2_chr17_31351032_ENST00000225823_length(transcript)=4384nt_BP=3009nt
GAAGGATGCGTGTGTGCCGGTCTGCTGTGCATGTGTGTATCTGCATGTCTGTGATGCATGCGCATGCGTCTGTATGTGCATTGTGTGTGC
AGGACTTTGATTCTGTGCAACTCTGTGCATATCTATGTGTCTACAAAAGTGTGCACATGTGTACTCATTTGTGTGTGTGTATCTGTGTGT
CTGCATATTTGCACATGCTTGTCTGTATGTTTGTGGTATGTTCCGTCTACATGAGTGTATGTGGCTGGGGCTGTGTCTGCATAAGTATGT
GTCTATCTGGGAGTGCATATATGTGTGCATGTGTGTGTGTGAGATTGTGCATGAGCTAAGACAACGACAGGCACTTCCTGGGCAGGAAGG
CTGTATCCAGGGTCCTGCACATAGTAGGTGCTCAGTGAACATTTGCTGAACTCAGCTGAACTGAACTGAATGAACTTGCTTCACTGCCAC
TGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCTGGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCT
TTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGTCGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAG
GAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCATCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGC
TTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCGTCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTG
ATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACATCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGC
CGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGATCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCA
GGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTGACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCAC
CTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGAGCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGC
CCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGCCCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAA
ACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCATGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGG
CTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTTTGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACT
ACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAGGGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGC
GTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGCCAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACC
TCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGCGCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTG
GGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCATTCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCA
GCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATGAGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGA
CCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCCCAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGG
CCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCTTTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACG
TCCCTGCCTCTGCTGTGGTCTCCAGTGCCATGAACTCAGCCCCTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCG
GACGCCATTACTCGCAGGACTGCAGCAGCATCAAGGCTGGCCGCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCT
GCGATGATGGACTCAACACCTTCCGCGACGAGGGCCGGGTTCTGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCT
TCTTCACCGACGGGTCCTTGGATAGCTGGGGCACCTCTGAAGATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATG
CGACCTTCAGCGATATCAGGAGAGAAGGCTGGTTGTATTATAAGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCC
AGTGGAAGCGGGTGTACGCCGCGCTGCGGGCGCGCTCGCTCTCGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTG
CGGCGGCCGGCGCAGGTGAGGACGAGGCGGCGCCCGTCTGCATCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGC
ACGTGTTCCGGCTGACCACCGCTGACTTCTGTGAATATCTCTTTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCC
GGGAGAACAGCAGGGCCGAGGGCGAGGACCCCGGCTGTGCCAACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCC
ATAGCTCTGGGCCCAAAGCTGATTCCTCCCCCAAAGGCTCTCGCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCAC
GTGGCCTCAGGACTCAGGACCTGCCCGCAGGGAGCAAGGGTCTGTTGGCGGAAAAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCA
ACCTAACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAAGTACCTTGAGAAGAAATTTAACAAATCAG
AAAAATATATCTCAGAGAACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGAGACAATTGAACAGAAGAAGGCGTATGAAG
TTGCTGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCTTACAATACTAGAGCTCTTTGATTATATTT
ATGAGCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCACGATGAGAATGTGAGTACTTGTGACACAA
TGCCAAACCACTCTGAAACCATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGCTGACACC
CCTCGAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAACAGCAAGCTCAGGTGGGATGGCCCCAGTG
CTGGAAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCCGGCCACGTCCAACACGACGCATCCTTGGG
CCCCGCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAACCTGCCATCACATCTCACTGCCAGATGTAT
AAAGCACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACACTCCTCCACGCGGTTTCCAGTGTCCACAC
TGCTGCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAATCAGAACTGCACAATCAAGAGGGAACCCAT
GGGACTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAACCCCCTTTTCCCCAAGCTGCCCATGGGGC
TTCGGCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCACAGCAGCCAGCGGGTGGGGGACGCCTGTGT
TCACCCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCTTTTTATCTGGGGTAGGGGGGCTTTTATGT
TTGTCCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGATGTTCTGAGGTTTGCTTTGGTTTTTCCATT

>5998_5998_5_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000443378_ASIC2_chr17_31351032_ENST00000225823_length(amino acids)=1026AA_BP=861
MNELASLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKE
DGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY
APPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQ
QALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRF
ERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEP
PRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSP
SIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRI
PSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERRE
PGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKK
LNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKY
LEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHD

--------------------------------------------------------------
>5998_5998_6_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000443378_ASIC2_chr17_31351032_ENST00000359872_length(transcript)=4384nt_BP=3009nt
GAAGGATGCGTGTGTGCCGGTCTGCTGTGCATGTGTGTATCTGCATGTCTGTGATGCATGCGCATGCGTCTGTATGTGCATTGTGTGTGC
AGGACTTTGATTCTGTGCAACTCTGTGCATATCTATGTGTCTACAAAAGTGTGCACATGTGTACTCATTTGTGTGTGTGTATCTGTGTGT
CTGCATATTTGCACATGCTTGTCTGTATGTTTGTGGTATGTTCCGTCTACATGAGTGTATGTGGCTGGGGCTGTGTCTGCATAAGTATGT
GTCTATCTGGGAGTGCATATATGTGTGCATGTGTGTGTGTGAGATTGTGCATGAGCTAAGACAACGACAGGCACTTCCTGGGCAGGAAGG
CTGTATCCAGGGTCCTGCACATAGTAGGTGCTCAGTGAACATTTGCTGAACTCAGCTGAACTGAACTGAATGAACTTGCTTCACTGCCAC
TGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCTGGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCT
TTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGTCGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAG
GAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCATCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGC
TTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCGTCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTG
ATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACATCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGC
CGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGATCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCA
GGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTGACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCAC
CTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGAGCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGC
CCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGCCCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAA
ACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCATGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGG
CTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTTTGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACT
ACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAGGGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGC
GTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGCCAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACC
TCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGCGCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTG
GGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCATTCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCA
GCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATGAGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGA
CCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCCCAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGG
CCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCTTTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACG
TCCCTGCCTCTGCTGTGGTCTCCAGTGCCATGAACTCAGCCCCTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCG
GACGCCATTACTCGCAGGACTGCAGCAGCATCAAGGCTGGCCGCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCT
GCGATGATGGACTCAACACCTTCCGCGACGAGGGCCGGGTTCTGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCT
TCTTCACCGACGGGTCCTTGGATAGCTGGGGCACCTCTGAAGATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATG
CGACCTTCAGCGATATCAGGAGAGAAGGCTGGTTGTATTATAAGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCC
AGTGGAAGCGGGTGTACGCCGCGCTGCGGGCGCGCTCGCTCTCGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTG
CGGCGGCCGGCGCAGGTGAGGACGAGGCGGCGCCCGTCTGCATCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGC
ACGTGTTCCGGCTGACCACCGCTGACTTCTGTGAATATCTCTTTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCC
GGGAGAACAGCAGGGCCGAGGGCGAGGACCCCGGCTGTGCCAACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCC
ATAGCTCTGGGCCCAAAGCTGATTCCTCCCCCAAAGGCTCTCGCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCAC
GTGGCCTCAGGACTCAGGACCTGCCCGCAGGGAGCAAGGGTCTGTTGGCGGAAAAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCA
ACCTAACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAAGTACCTTGAGAAGAAATTTAACAAATCAG
AAAAATATATCTCAGAGAACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGAGACAATTGAACAGAAGAAGGCGTATGAAG
TTGCTGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCTTACAATACTAGAGCTCTTTGATTATATTT
ATGAGCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCACGATGAGAATGTGAGTACTTGTGACACAA
TGCCAAACCACTCTGAAACCATCAGTCACACTGTGAACGTGCCCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGCTGACACC
CCTCGAGTCACCCAGCACTCCCTCCAAACAGACCTTGAGGCCCAAGACCCAGGACAAGGAACAGCAAGCTCAGGTGGGATGGCCCCAGTG
CTGGAAAGAAGCAAGAGCCCCCTATGCACACATTGCAGACTAGCTGCCTAGACCTCGCTCCGGCCACGTCCAACACGACGCATCCTTGGG
CCCCGCCGTGCGTCCCTCTTAGGAGAGATGAGTCACACTCTGGAACTGTCCAAGAACGAACCTGCCATCACATCTCACTGCCAGATGTAT
AAAGCACCTGCATGCTCAGACTTCTTGTGGCGCCACCTCCACGTCTGTCTTGTACATGACACTCCTCCACGCGGTTTCCAGTGTCCACAC
TGCTGCCCGTGCAGTGGGACCAGATTCCAGGTCCAAAGTCACCATGAGGCCACCCTGGAATCAGAACTGCACAATCAAGAGGGAACCCAT
GGGACTCTCTGCTACATTCAGTTCTTGTGTCGTTTGTGAAAGTTCTTAACCTGCCCAAAAACCCCCTTTTCCCCAAGCTGCCCATGGGGC
TTCGGCGCCAAAGGTGACCCGCGCCAACCTCCCTCCCCCCCAGTGCCTATGACGGCGGCACAGCAGCCAGCGGGTGGGGGACGCCTGTGT
TCACCCATGGTGCCCATGTCGTTCTTCTCTCCCTGTGACACAGCTTGTACAGTCTGATTCTTTTTATCTGGGGTAGGGGGGCTTTTATGT
TTGTCCGATGGAGATTTGTTTTGTTTTGCTTCATTTTATGCTTTTTTATTTTAGTTTTGATGTTCTGAGGTTTGCTTTGGTTTTTCCATT

>5998_5998_6_ARHGAP23-ASIC2_ARHGAP23_chr17_36636124_ENST00000443378_ASIC2_chr17_31351032_ENST00000359872_length(amino acids)=1026AA_BP=861
MNELASLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKE
DGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY
APPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQ
QALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRF
ERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEP
PRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSP
SIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRI
PSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERRE
PGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKK
LNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKY
LEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP23-ASIC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP23-ASIC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved
TgeneASIC2Q16515DB00594AmilorideInhibitorSmall moleculeApproved

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Related Diseases for ARHGAP23-ASIC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP23C0032460Polycystic Ovary Syndrome1CTD_human
HgeneARHGAP23C1136382Sclerocystic Ovaries1CTD_human
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0021368Inflammation1CTD_human