Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGAP23-GOSR2 (FusionGDB2 ID:HG57636TG9570)

Fusion Gene Summary for ARHGAP23-GOSR2

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP23-GOSR2
	Fusion gene ID: hg57636tg9570
		Hgene	Tgene
	Gene symbol	ARHGAP23	GOSR2
	Gene ID	57636	9570
	Gene name	Rho GTPase activating protein 23	golgi SNAP receptor complex member 2
	Synonyms	-	Bos1\|EPM6\|GS27
	Cytomap	('ARHGAP23')('GOSR2') 17q12	17q21.32
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 23rho-type GTPase-activating protein 23	Golgi SNAP receptor complex member 227 kDa Golgi SNARE proteinmembrin
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000437668, ENST00000431231, ENST00000443378, ENST00000582409,
Fusion gene scores	* DoF score	13 X 12 X 10=1560	4 X 4 X 4=64
	# samples	14	4
	** MAII score	log2(14/1560*10)=-3.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARHGAP23 [Title/Abstract] AND GOSR2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGAP23(36656870)-GOSR2(45009433), # samples:2
Anticipated loss of major functional domain due to fusion event.	ARHGAP23-GOSR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGAP23-GOSR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGAP23-GOSR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGAP23-GOSR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGAP23-GOSR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GOSR2	GO:0006888	ER to Golgi vesicle-mediated transport	9349823
Tgene	GOSR2	GO:0006891	intra-Golgi vesicle-mediated transport	9349823

Fusion gene breakpoints across ARHGAP23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GOSR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-HQ-A2OF-01A	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+

Top

Fusion Gene ORF analysis for ARHGAP23-GOSR2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000437668	ENST00000225567	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
3UTR-3CDS	ENST00000437668	ENST00000393456	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
3UTR-3CDS	ENST00000437668	ENST00000415811	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
3UTR-3CDS	ENST00000437668	ENST00000439730	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
3UTR-3CDS	ENST00000437668	ENST00000575949	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
3UTR-3CDS	ENST00000437668	ENST00000576910	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000431231	ENST00000225567	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000431231	ENST00000393456	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000431231	ENST00000415811	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000431231	ENST00000439730	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000431231	ENST00000576910	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000443378	ENST00000225567	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000443378	ENST00000393456	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000443378	ENST00000415811	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000443378	ENST00000439730	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
Frame-shift	ENST00000443378	ENST00000576910	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
In-frame	ENST00000431231	ENST00000575949	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
In-frame	ENST00000443378	ENST00000575949	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
intron-3CDS	ENST00000582409	ENST00000225567	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
intron-3CDS	ENST00000582409	ENST00000393456	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
intron-3CDS	ENST00000582409	ENST00000415811	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
intron-3CDS	ENST00000582409	ENST00000439730	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
intron-3CDS	ENST00000582409	ENST00000575949	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+
intron-3CDS	ENST00000582409	ENST00000576910	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000431231

ARHGAP23

chr17

36656870

ENST00000575949

GOSR2

chr17

45009433

3915

3515

3523

1168

ENST00000443378

ARHGAP23

chr17

36656870

ENST00000575949

GOSR2

chr17

45009433

4227

3827

425

3835

1136

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000431231	ENST00000575949	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+	0.003482166	0.9965178
ENST00000443378	ENST00000575949	ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009433	+	0.004331449	0.99566853

Top

Fusion Genomic Features for ARHGAP23-GOSR2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009432	+	0.000567712	0.99943227
ARHGAP23	chr17	36656870	+	GOSR2	chr17	45009432	+	0.000567712	0.99943227

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ARHGAP23-GOSR2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:36656870/chr17:45009433)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000431231

183_279

1149

1492.0

Compositional bias

Note=Pro-rich

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000437668

1320_1405

1156

1145.0

Compositional bias

Note=Arg-rich

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000437668

183_279

1156

1145.0

Compositional bias

Note=Pro-rich

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000431231

688_808

1149

1492.0

Domain

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000431231

71_155

1149

1492.0

Domain

PDZ

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000431231

905_1097

1149

1492.0

Domain

Rho-GAP

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000437668

688_808

1156

1145.0

Domain

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000437668

71_155

1156

1145.0

Domain

PDZ

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000437668

905_1097

1156

1145.0

Domain

Rho-GAP

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000225567

118_120

214.0

Motif

IxM motif%3B signal for cargo packaging into COPII-coated vesicles

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000393456

118_120

213.0

Motif

IxM motif%3B signal for cargo packaging into COPII-coated vesicles

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000415811

118_120

196.0

Motif

IxM motif%3B signal for cargo packaging into COPII-coated vesicles

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000225567

212_212

214.0

Topological domain

Vesicular

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000393456

212_212

213.0

Topological domain

Vesicular

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000415811

212_212

196.0

Topological domain

Vesicular

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000225567

191_211

214.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000393456

191_211

213.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000415811

191_211

196.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP23

chr17:36656870

chr17:45009433

ENST00000431231

1320_1405

1149

1492.0

Compositional bias

Note=Arg-rich

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000225567

61_107

214.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000393456

61_107

213.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000415811

61_107

196.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000225567

1_190

214.0

Topological domain

Cytoplasmic

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000393456

1_190

213.0

Topological domain

Cytoplasmic

Tgene

GOSR2

chr17:36656870

chr17:45009433

ENST00000415811

1_190

196.0

Topological domain

Cytoplasmic

Top

Fusion Gene Sequence for ARHGAP23-GOSR2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>6001_6001_1_ARHGAP23-GOSR2_ARHGAP23_chr17_36656870_ENST00000431231_GOSR2_chr17_45009433_ENST00000575949_length(transcript)=3915nt_BP=3515nt
CCGCCCCTCCCGGGTCCCTGCCGGCGCCCCCAGCCGTGCCCCGGCCGCAGAGCCGCCGCTGCCACCCGATGAATGGAGTCGCCTTCTGCC
TGGTCGGGATCCCGCCCCGCCCGGAGCCCCGGCCCCCACAGCTGCCACTGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCT
GGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCTTTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGT
CGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAGGAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCA
TCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGCTTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCG
TCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTGATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACA
TCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGCCGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGA
TCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCAGGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTG
ACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCACCTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGA
GCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGCCCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGC
CCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAAACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCA
TGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGGCTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTT
TGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACTACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAG
GGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGCGTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGC
CAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACCTCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGC
GCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTGGGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCAT
TCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCAGCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATG
AGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGACCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCC
CAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGGCCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCT
TTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACGTCCCTGCCTCTGCTGTGGTCTCCAGTGCCATGAACTCAGCCC
CTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCGGACGCCATTACTCGCAGGACTGCAGCAGCATCAAGGCTGGCC
GCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCTGCGATGATGGACTCAACACCTTCCGCGACGAGGGCCGGGTTC
TGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCTTCTTCACCGACGGGTCCTTGGATAGCTGGGGCACCTCTGAAG
ATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATGCGACCTTCAGCGATATCAGGAGAGAAGGCTGGTTGTATTATA
AGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCCAGTGGAAGCGGGTGTACGCCGCGCTGCGGGCGCGCTCGCTCT
CGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTGCGGCGGCCGGCGCAGGTGAGGACGAGGCGGCGCCCGTCTGCA
TCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGCACGTGTTCCGGCTGACCACCGCTGACTTCTGTGAATATCTCT
TTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCCGGGAGAACAGCAGGGCCGAGGGCGAGGACCCCGGCTGTGCCA
ACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCCATAGCTCTGGGCCCAAAGCTGATTCCTCCCCCAAAGGCTCTC
GCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCACGTGGCCTCAGGACTCAGGACCTGCCCGCAGGGAGCAAGGATG
ACAGTGCTGCAGCCCCCAAAACCCCCTGGGGCATCAACATCATCAAGAAAAATAAGAAGGCCGCTCCGAGGGCGTTTGGGGTCAGGCTGG
AGGAGTGCCAGCCAGCCACGGAGAACCAGCGCGTCCCCTTAATCGTGGCTGCATGCTGTCGCATTGTGGAGGCACGAGGGCTGGAGTCCA
CAGGCATTTACCGAGTGCCCGGCAACAATGCAGTGGTGTCCAGCCTACAGGAGCAGCTCAACCGCGGGCCTGGTGACATCAACCTGCAGG
ATGAGCGCTGGCAAGACCTCAATGTGATCAGCAGCCTGCTCAAGTCCTTCTTCCGAAAGCTGCCCGAGCCTCTTTTCACTGATGACAAAT
ACAACGACTTCATCGAGGCCAACCGCATTGAGGACGCACGGGAGCGAATGAGGACGCTGCGGAAGCTGATCCGGGATCTCCCAGGACACT
ACTATGAAACGCTCAAATTCCTTGTGGGCCATCTCAAGACCATCGCTGACCACTCTGAGAAAAACAAGATGGAACCCCGGAACCTGGCCC
TGGTCTTTGGGCCGACACTGGTGAGGACGTCTGAGGACAACATGACAGACATGGTGACCCACATGCCTGACCGCTACAAGATCGTGGAGA
CACTGATCCAGCACTCAGACTGGTTCTTCAGTGACGAAGAGGACAAGGGAGAGAGAACCCCTGTGGGCGACAAGGAGCCTCAGGCAGTGC
CCAACATTGAGTACCTCCTGCCCAACATTGGCAGGACAGTGCCCCCTGGCGACCCGGGGTCAGATTCTACCACCTGTAGTTCAGCCAAGT
CCAAGTCGGGTTGACCAGTTAAAGTATGATGTCCAGCACCTGCAGACTGCGCTCAGAAACTTCCAGCATCGGCGCCATGCAAGGGAGCAG
CAGGAGAGACAGCGAGAAGAGCTTCTGTCTCGAACCTTCACCACTAACGTAAGCCAGGCCCGTGGTGAGGGTCGGCCTGCACTTGACAGA
TCGTGGGGGCTGGAGTTCAGATCTCTGAGCGCCATCTGTTTTGGGGGTGTCTGAAGAAGACTGATGATGAGGAAACCAACTGGAAATGAC
AGGAACTTTGTGCATTGCCACAGAGACTAGACCTAGACAGAGAATCCCTTTTTCTAAGACAAAAACCTGAAGAGGAAGCAGTTAAATTGA

>6001_6001_1_ARHGAP23-GOSR2_ARHGAP23_chr17_36656870_ENST00000431231_GOSR2_chr17_45009433_ENST00000575949_length(amino acids)=1168AA_BP=
MPAPPAVPRPQSRRCHPMNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCS
LKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAY
SQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPS
PGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQ
EGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLL
HALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEAS
GRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYL
LAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTK
KGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDR
DDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAP
KTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQD
LNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPT

--------------------------------------------------------------
>6001_6001_2_ARHGAP23-GOSR2_ARHGAP23_chr17_36656870_ENST00000443378_GOSR2_chr17_45009433_ENST00000575949_length(transcript)=4227nt_BP=3827nt
GAAGGATGCGTGTGTGCCGGTCTGCTGTGCATGTGTGTATCTGCATGTCTGTGATGCATGCGCATGCGTCTGTATGTGCATTGTGTGTGC
AGGACTTTGATTCTGTGCAACTCTGTGCATATCTATGTGTCTACAAAAGTGTGCACATGTGTACTCATTTGTGTGTGTGTATCTGTGTGT
CTGCATATTTGCACATGCTTGTCTGTATGTTTGTGGTATGTTCCGTCTACATGAGTGTATGTGGCTGGGGCTGTGTCTGCATAAGTATGT
GTCTATCTGGGAGTGCATATATGTGTGCATGTGTGTGTGTGAGATTGTGCATGAGCTAAGACAACGACAGGCACTTCCTGGGCAGGAAGG
CTGTATCCAGGGTCCTGCACATAGTAGGTGCTCAGTGAACATTTGCTGAACTCAGCTGAACTGAACTGAATGAACTTGCTTCACTGCCAC
TGGGCCCAAGAGATGGGTGCTCTCCTAGGCGCCCCTTCCCCTGGCAGGGGCCGAGGACGCTGCTGCTGTACAAAAGTCCCCAGGACGGCT
TTGGCTTCACTCTGCGCCACTTCATCGTGTACCCACCCGAGTCGGCCGTGCACTGCAGCCTGAAGGAGGAAGAGAATGGAGGCCGTGGAG
GAGGACCCTCCCCCCGGTACCGCCTGGAGCCCATGGACACCATCTTTGTCAAGAATGTGAAGGAAGACGGCCCTGCCCATAGGGCGGGGC
TTCGCACAGGAGACCGGCTGGTAAAGGTGAATGGGGAAAGCGTCATTGGGAAGACCTACTCTCAGGTCATAGCTCTGATCCAGAATAGTG
ATGACACTCTGGAGCTGTCTATCATGCCCAAGGACGAGGACATCCTCCAGCTGGCCTACTCCCAGGATGCCTACCTGAAAGGGAACGAGC
CGTATTCTGGAGAGGCCCGCAGCATCCCAGAGCCACCGCCGATCTGCTACCCCCGCAAGACCTACGCCCCTCCTGCCCGGGCCTCCACCA
GGGCCACTATGGTGCCTGAGCCCACCTCAGCACTGCCCAGTGACCCCCGGAGTCCTGCTGCCTGGAGTGACCCGGGGCTCCGTGTGCCAC
CTGCTGCCCGTGCCCACCTGGACAACTCTTCCTTGGGGATGAGCCAGCCCCGCCCCAGCCCTGGTGCCTTCCCCCACCTCTCCTCGGAGC
CCCGGACGCCCCGTGCCTTCCCAGAGCCTGGCAGCCGGGTGCCCCCCAGCAGACTGGAGTGCCAGCAGGCCTTGTCACACTGGCTGTCAA
ACCAGGTACCCCGCCGGGCGGGGGAGAGACGGTGCCCAGCCATGGCCCCCCGGGCCCGCAGCGCCTCCCAGGACCGGTTGGAGGAGGTGG
CTGCCCCCCGCCCGTGGCCCTGCTCCACCTCCCAGGATGCTTTGAGCCAGCTGGGCCAGGAGGGCTGGCACCGAGCTCGCTCAGATGACT
ACTTGAGCCGGGCCACCCGTTCTGCCGAGGCACTGGGGCCAGGGGCACTGGTGTCACCCCGCTTTGAGCGGTGTGGCTGGGCTTCCCAGC
GTTCGTCTGCCCGCACCCCCGCCTGCCCAACTCGGGACCTGCCAGGGCCCCAGGCCCCACCCCCGTCTGGCCTGCAGGGCCTGGATGACC
TCGGGTACATCGGCTACCGGAGCTACAGCCCATCATTCCAGCGCCGGACCGGCCTCCTCCATGCGCTCTCCTTCCGGGACTCACCCTTTG
GGGGGCTGCCTACCTTCAACCTGGCCCAGTCCCCTGCGTCATTCCCACCAGAGGCCTCCGAGCCACCCAGGGTTGTACGGCCGGAACCCA
GCACCCGGGCCCTGGAGCCTCCTGCGGAGGATCGCGGCGATGAGGTGGTCCTGAGGCAGAAGCCCCCGACGGGCCGCAAGGTTCAGCTGA
CCCCCGCAAGACAGATGAACCTTGGATTTGGTGACGAGTCCCCAGAGCCAGAGGCCAGTGGGCGAGGGGAACGCCTGGGCAGGAAGGTGG
CCCCTTTGGCCACCACCGAAGACTCTCTGGCTTCCATCCCCTTTATTGATGAGCCCACCAGCCCCAGCATTGACCTCCAAGCCAAGCACG
TCCCTGCCTCTGCTGTGGTCTCCAGTGCCATGAACTCAGCCCCTGTCCTGGGCACCAGCCCATCTTCCCCGACCTTCACTTTCACCCTCG
GACGCCATTACTCGCAGGACTGCAGCAGCATCAAGGCTGGCCGCCGCTCCTCCTACCTGCTGGCCATCACCACGGAGCGCTCCAAGTCCT
GCGATGATGGACTCAACACCTTCCGCGACGAGGGCCGGGTTCTGCGGCGCCTGCCAAACCGCATACCCAGCCTGCGGATGCTCCGGAGCT
TCTTCACCGACGGGTCCTTGGATAGCTGGGGCACCTCTGAAGATGCTGACGCTCCTTCTAAGCGACACTCAACCTCTGACCTCTCAGATG
CGACCTTCAGCGATATCAGGAGAGAAGGCTGGTTGTATTATAAGCAGATTCTCACCAAGAAGGGGAAGAAAGCGGGCAGCGGCCTGCGCC
AGTGGAAGCGGGTGTACGCCGCGCTGCGGGCGCGCTCGCTCTCGCTGAGCAAGGAGCGGCGGGAGCCCGGGCCGGCGGCGGCGGGGGCTG
CGGCGGCCGGCGCAGGTGAGGACGAGGCGGCGCCCGTCTGCATCGGCTCCTGCCTCGTGGACATCTCCTACAGCGAGACCAAGAGGAGGC
ACGTGTTCCGGCTGACCACCGCTGACTTCTGTGAATATCTCTTTCAGGCTGAGGACCGGGATGACATGCTGGGCTGGATCAGAGCGATCC
GGGAGAACAGCAGGGCCGAGGGCGAGGACCCCGGCTGTGCCAACCAAGCTCTGATCAGCAAGAAGCTTAACGATTATCGCAAAGTGAGCC
ATAGCTCTGGGCCCAAAGCTGATTCCTCCCCCAAAGGCTCTCGCGGCCTGGGGGGCCTCAAGTCTGAGTTCCTCAAGCAGAGTGCGGCAC
GTGGCCTCAGGACTCAGGACCTGCCCGCAGGGAGCAAGGATGACAGTGCTGCAGCCCCCAAAACCCCCTGGGGCATCAACATCATCAAGA
AAAATAAGAAGGCCGCTCCGAGGGCGTTTGGGGTCAGGCTGGAGGAGTGCCAGCCAGCCACGGAGAACCAGCGCGTCCCCTTAATCGTGG
CTGCATGCTGTCGCATTGTGGAGGCACGAGGGCTGGAGTCCACAGGCATTTACCGAGTGCCCGGCAACAATGCAGTGGTGTCCAGCCTAC
AGGAGCAGCTCAACCGCGGGCCTGGTGACATCAACCTGCAGGATGAGCGCTGGCAAGACCTCAATGTGATCAGCAGCCTGCTCAAGTCCT
TCTTCCGAAAGCTGCCCGAGCCTCTTTTCACTGATGACAAATACAACGACTTCATCGAGGCCAACCGCATTGAGGACGCACGGGAGCGAA
TGAGGACGCTGCGGAAGCTGATCCGGGATCTCCCAGGACACTACTATGAAACGCTCAAATTCCTTGTGGGCCATCTCAAGACCATCGCTG
ACCACTCTGAGAAAAACAAGATGGAACCCCGGAACCTGGCCCTGGTCTTTGGGCCGACACTGGTGAGGACGTCTGAGGACAACATGACAG
ACATGGTGACCCACATGCCTGACCGCTACAAGATCGTGGAGACACTGATCCAGCACTCAGACTGGTTCTTCAGTGACGAAGAGGACAAGG
GAGAGAGAACCCCTGTGGGCGACAAGGAGCCTCAGGCAGTGCCCAACATTGAGTACCTCCTGCCCAACATTGGCAGGACAGTGCCCCCTG
GCGACCCGGGGTCAGATTCTACCACCTGTAGTTCAGCCAAGTCCAAGTCGGGTTGACCAGTTAAAGTATGATGTCCAGCACCTGCAGACT
GCGCTCAGAAACTTCCAGCATCGGCGCCATGCAAGGGAGCAGCAGGAGAGACAGCGAGAAGAGCTTCTGTCTCGAACCTTCACCACTAAC
GTAAGCCAGGCCCGTGGTGAGGGTCGGCCTGCACTTGACAGATCGTGGGGGCTGGAGTTCAGATCTCTGAGCGCCATCTGTTTTGGGGGT
GTCTGAAGAAGACTGATGATGAGGAAACCAACTGGAAATGACAGGAACTTTGTGCATTGCCACAGAGACTAGACCTAGACAGAGAATCCC

>6001_6001_2_ARHGAP23-GOSR2_ARHGAP23_chr17_36656870_ENST00000443378_GOSR2_chr17_45009433_ENST00000575949_length(amino acids)=1136AA_BP=
MNELASLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKE
DGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY
APPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQ
QALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRF
ERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEP
PRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSP
SIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRI
PSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERRE
PGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKK
LNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATE
NQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEAN
RIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDW

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARHGAP23-GOSR2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ARHGAP23-GOSR2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ARHGAP23-GOSR2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ARHGAP23	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Hgene	ARHGAP23	C1136382	Sclerocystic Ovaries	1	CTD_human
Tgene		C3279627	EPILEPSY, PROGRESSIVE MYOCLONIC, 6	3	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0004238	Atrial Fibrillation	1	CTD_human
Tgene		C0235480	Paroxysmal atrial fibrillation	1	CTD_human
Tgene		C2585653	Persistent atrial fibrillation	1	CTD_human
Tgene		C3468561	familial atrial fibrillation	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ARHGAP23-GOSR2 (FusionGDB2 ID:HG57636TG9570)

Fusion Gene Summary for ARHGAP23-GOSR2

Fusion Gene ORF analysis for ARHGAP23-GOSR2

Fusion Genomic Features for ARHGAP23-GOSR2

Fusion Protein Features for ARHGAP23-GOSR2

Fusion Gene Sequence for ARHGAP23-GOSR2

Fusion Gene PPI Analysis for ARHGAP23-GOSR2

Related Drugs for ARHGAP23-GOSR2

Related Diseases for ARHGAP23-GOSR2

Fusion Gene Studies
in Kim Lab