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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIAA1598-ATXN10 (FusionGDB2 ID:HG57698TG25814)

Fusion Gene Summary for KIAA1598-ATXN10

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1598-ATXN10
Fusion gene ID: hg57698tg25814
HgeneTgene
Gene symbol

KIAA1598

ATXN10

Gene ID

57698

25814

Gene nameshootin 1ataxin 10
SynonymsKIAA1598|shootin-1E46L|HUMEEP|SCA10
Cytomap('KIAA1598')('ATXN10')

10q25.3

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionshootin-1shootin1ataxin-10brain protein E46 homologspinocerebellar ataxia type 10 protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355371, ENST00000392901, 
ENST00000392903, ENST00000497044, 
ENST00000260777, 
Fusion gene scores* DoF score9 X 4 X 7=25224 X 19 X 12=5472
# samples 928
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(28/5472*10)=-4.28856949794093
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1598 [Title/Abstract] AND ATXN10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIAA1598(118661276)-ATXN10(46114293), # samples:1
Anticipated loss of major functional domain due to fusion event.KIAA1598-ATXN10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA1598-ATXN10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA1598-ATXN10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA1598-ATXN10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA1598-ATXN10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA1598

GO:2001224

positive regulation of neuron migration

23864681

TgeneATXN10

GO:0031175

neuron projection development

16498633


check buttonFusion gene breakpoints across KIAA1598 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATXN10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BH-A0HA-11AKIAA1598chr10

118661276

-ATXN10chr22

46114293

+


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Fusion Gene ORF analysis for KIAA1598-ATXN10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000355371ENST00000498009KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
5CDS-3UTRENST00000392901ENST00000498009KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
5CDS-3UTRENST00000392903ENST00000498009KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
5CDS-intronENST00000355371ENST00000402380KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
5CDS-intronENST00000392901ENST00000402380KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
5CDS-intronENST00000392903ENST00000402380KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
5UTR-3CDSENST00000497044ENST00000252934KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
5UTR-3CDSENST00000497044ENST00000381061KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
5UTR-3UTRENST00000497044ENST00000498009KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
5UTR-intronENST00000497044ENST00000402380KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
Frame-shiftENST00000392901ENST00000252934KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
Frame-shiftENST00000392901ENST00000381061KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
In-frameENST00000355371ENST00000252934KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
In-frameENST00000355371ENST00000381061KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
In-frameENST00000392903ENST00000252934KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
In-frameENST00000392903ENST00000381061KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
intron-3CDSENST00000260777ENST00000252934KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
intron-3CDSENST00000260777ENST00000381061KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
intron-3UTRENST00000260777ENST00000498009KIAA1598chr10

118661276

-ATXN10chr22

46114293

+
intron-intronENST00000260777ENST00000402380KIAA1598chr10

118661276

-ATXN10chr22

46114293

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000392903KIAA1598chr10118661276-ENST00000381061ATXN10chr2246114293+458521714202951843
ENST00000392903KIAA1598chr10118661276-ENST00000252934ATXN10chr2246114293+458821714202951843
ENST00000355371KIAA1598chr10118661276-ENST00000381061ATXN10chr2246114293+458521714202951843
ENST00000355371KIAA1598chr10118661276-ENST00000252934ATXN10chr2246114293+458821714202951843

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392903ENST00000381061KIAA1598chr10118661276-ATXN10chr2246114293+0.0004672240.9995328
ENST00000392903ENST00000252934KIAA1598chr10118661276-ATXN10chr2246114293+0.0004642460.9995358
ENST00000355371ENST00000381061KIAA1598chr10118661276-ATXN10chr2246114293+0.0004672240.9995328
ENST00000355371ENST00000252934KIAA1598chr10118661276-ATXN10chr2246114293+0.0004642460.9995358

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Fusion Genomic Features for KIAA1598-ATXN10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIAA1598chr10118661275-ATXN10chr2246114292+2.14E-050.99997854
KIAA1598chr10118661275-ATXN10chr2246114292+2.14E-050.99997854

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KIAA1598-ATXN10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:118661276/chr22:46114293)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA1598chr10:118661276chr22:46114293ENST00000355371-16177_353557632.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1598chr10:118661276chr22:46114293ENST00000392901-17187_353497499.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1598chr10:118661276chr22:46114293ENST00000392903-16187_353557650.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1598chr10:118661276chr22:46114293ENST00000355371-1617353_369557632.0Compositional biasNote=Pro-rich
HgeneKIAA1598chr10:118661276chr22:46114293ENST00000392901-1718353_369497499.0Compositional biasNote=Pro-rich
HgeneKIAA1598chr10:118661276chr22:46114293ENST00000392903-1618353_369557650.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA1598chr10:118661276chr22:46114293ENST00000260777-1157_3530457.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1598chr10:118661276chr22:46114293ENST00000260777-115353_3690457.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for KIAA1598-ATXN10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42393_42393_1_KIAA1598-ATXN10_KIAA1598_chr10_118661276_ENST00000355371_ATXN10_chr22_46114293_ENST00000252934_length(transcript)=4588nt_BP=2171nt
ATTGCGTCCCGCTCTACCTCTGTGGTTCTTTGGGAGCGACCCCCGGGAAGCGTCCAAAGTGGAGTTCCCACACACGCTGCGAACCCACAG
CCGGTTTTCTCTGAACTCGCGTCCCTGAGTCCGGGAGGTGGAGGCGGAGAAAAGGGTGCGGAGCGACCCCACGCAGGGCCGCCCCCCCTC
CCACCAGCGCGTCCTGCCGCGCCGGCAGCCACAGGCTGGCATAGCGGCTGCCGACCCGCCCTCGTTCCTCCACCCCCTGAACGGGACTGC
TGGGCCCGCCCCGCCCCGCCTGCAGGTGAAGCGGCCGCAGCCGCCGAGTAGGTGCGTGGGGATGATCTCACTCGCGCGCTCCGCGCCAGG
AGGAGGAGGAGCGGGAGCGGATCCAACTTCCGGGTAGTGGAGCCGCAAGCCACCGGCATCTTGCTTTTTCTTCCCCCTCCTCCTGTGTGC
CCCGCGCCGCTCCCTCTTTCCCTTTTATTCCCGGCCCCACCCGCCAAAATGAACAGCTCGGACGAAGAGAAGCAGCTGCAGCTCATTACC
AGTCTGAAGGAGCAAGCAATAGGCGAATATGAAGACCTTAGAGCAGAGAACCAGAAAACAAAGGAGAAGTGTGACAAAATTAGGCAAGAA
CGAGATGAAGCCGTTAAAAAACTGGAAGAATTTCAGAAAATTTCTCACATGGTCATAGAGGAAGTTAATTTCATGCAGAACCATCTTGAA
ATAGAGAAGACTTGTCGAGAAAGTGCTGAAGCTTTGGCAACAAAGCTAAATAAAGAAAATAAAACGTTGAAAAGAATCAGCATGTTGTAC
ATGGCCAAGCTGGGACCAGATGTAATAACTGAAGAGATAAACATTGATGATGAAGATTCGACTACAGACACAGACGGTGCCGCCGAGACT
TGTGTCTCAGTACAGTGTCAGAAGCAAATTAAAGAACTTCGAGATCAAATTGTATCTGTTCAGGAGGAAAAGAAGATTTTAGCCATTGAG
CTGGAAAATCTCAAGAGCAAACTCGTAGAAGTAATTGAAGAAGTAAATAAAGTTAAACAAGAAAAGACTGTTTTAAATTCAGAAGTTCTT
GAACAGAGAAAAGTCTTAGAAAAATGCAATAGAGTGTCCATGTTAGCTGTAGAAGAGTATGAGGAGATGCAAGTAAACCTGGAGCTGGAG
AAGGACCTTCGAAAGAAAGCAGAGTCATTTGCACAAGAGATGTTCATTGAGCAAAACAAGCTAAAGAGACAAAGCCACCTTCTGCTGCAG
AGCTCCATCCCTGATCAGCAGCTTTTGAAAGCTTTAGACGAAAATGCAAAACTCACCCAGCAACTTGAAGAAGAGAGAATTCAGCATCAA
CAAAAGGTCAAAGAATTAGAAGAGCAACTAGAAAATGAAACACTCCACAAAGAAATACACAACCTCAAACAGCAACTGGAGCTTCTAGAG
GAAGATAAAAAGGAATTGGAATTGAAATATCAGAATTCTGAAGAGAAAGCCAGAAATTTAAAGCACTCTGTTGATGAACTCCAGAAACGA
GTGAACCAGTCTGAGAATTCAGTACCTCCACCACCTCCTCCTCCACCACCACTTCCCCCTCCACCTCCCAATCCTATCCGATCCCTCATG
TCCATGATCCGGAAACGATCCCACCCCAGTGGCAGTGGTGCTAAGAAAGAAAAGGCAACTCAACCAGAAACAACTGAAGAAGTCACAGAT
CTAAAGAGGCAAGCAGTTGAAGAGATGATGGATAGAATTAAAAAGGGAGTTCATCTTAGACCCGTTAATCAGACAGCCAGACCGAAGACA
AAGCCAGAATCTTCGAAAGGCTGCGAAAGTGCAGTGGATGAACTAAAAGGAATACTGGGGACACTTAACAAATCCACTAGTTCAAGAAGC
TTAAAATCCCTTGACCCTGAAAACAGTGAAACTGAGTTAGAAAGGATTTTGCGTCGCAGAAAGGTGACAGCAGAAGCAGATAGCAGTAGT
CCAACTGGGATATTAGCCACCTCAGAGTCCAAATCCATGCCAGTGTTGGGTTCTGTATCCAGTGTAACAAAAACAGCCTTGAACAAGAAA
ACTCTGGAGGCAGAATTCAACAGCCCGTCCCCCCCAACACCTGAGCCAGGTGAAGGGCCCCGTAAATTGGAAGGATGCACAAGTTCCAAG
GTTACGTTTCAGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAA
AGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCT
GAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCT
ACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGA
GTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGAC
ATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTA
AATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATC
CGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAA
GTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATA
CCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGG
GAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATG
TAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTC
TCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTA
TATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCC
TCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTC
ACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCA
GAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCT
TATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTC
AGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATC
TATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGC
TCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCAC
AATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAA
GCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGT
ACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGT
AAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGC
CTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTG

>42393_42393_1_KIAA1598-ATXN10_KIAA1598_chr10_118661276_ENST00000355371_ATXN10_chr22_46114293_ENST00000252934_length(amino acids)=843AA_BP=584
MLFLPPPPVCPAPLPLSLLFPAPPAKMNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE
EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSV
QEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNK
LKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNL
KHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLR
PVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSVS
SVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTK
DDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFS
NCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQ

--------------------------------------------------------------
>42393_42393_2_KIAA1598-ATXN10_KIAA1598_chr10_118661276_ENST00000355371_ATXN10_chr22_46114293_ENST00000381061_length(transcript)=4585nt_BP=2171nt
ATTGCGTCCCGCTCTACCTCTGTGGTTCTTTGGGAGCGACCCCCGGGAAGCGTCCAAAGTGGAGTTCCCACACACGCTGCGAACCCACAG
CCGGTTTTCTCTGAACTCGCGTCCCTGAGTCCGGGAGGTGGAGGCGGAGAAAAGGGTGCGGAGCGACCCCACGCAGGGCCGCCCCCCCTC
CCACCAGCGCGTCCTGCCGCGCCGGCAGCCACAGGCTGGCATAGCGGCTGCCGACCCGCCCTCGTTCCTCCACCCCCTGAACGGGACTGC
TGGGCCCGCCCCGCCCCGCCTGCAGGTGAAGCGGCCGCAGCCGCCGAGTAGGTGCGTGGGGATGATCTCACTCGCGCGCTCCGCGCCAGG
AGGAGGAGGAGCGGGAGCGGATCCAACTTCCGGGTAGTGGAGCCGCAAGCCACCGGCATCTTGCTTTTTCTTCCCCCTCCTCCTGTGTGC
CCCGCGCCGCTCCCTCTTTCCCTTTTATTCCCGGCCCCACCCGCCAAAATGAACAGCTCGGACGAAGAGAAGCAGCTGCAGCTCATTACC
AGTCTGAAGGAGCAAGCAATAGGCGAATATGAAGACCTTAGAGCAGAGAACCAGAAAACAAAGGAGAAGTGTGACAAAATTAGGCAAGAA
CGAGATGAAGCCGTTAAAAAACTGGAAGAATTTCAGAAAATTTCTCACATGGTCATAGAGGAAGTTAATTTCATGCAGAACCATCTTGAA
ATAGAGAAGACTTGTCGAGAAAGTGCTGAAGCTTTGGCAACAAAGCTAAATAAAGAAAATAAAACGTTGAAAAGAATCAGCATGTTGTAC
ATGGCCAAGCTGGGACCAGATGTAATAACTGAAGAGATAAACATTGATGATGAAGATTCGACTACAGACACAGACGGTGCCGCCGAGACT
TGTGTCTCAGTACAGTGTCAGAAGCAAATTAAAGAACTTCGAGATCAAATTGTATCTGTTCAGGAGGAAAAGAAGATTTTAGCCATTGAG
CTGGAAAATCTCAAGAGCAAACTCGTAGAAGTAATTGAAGAAGTAAATAAAGTTAAACAAGAAAAGACTGTTTTAAATTCAGAAGTTCTT
GAACAGAGAAAAGTCTTAGAAAAATGCAATAGAGTGTCCATGTTAGCTGTAGAAGAGTATGAGGAGATGCAAGTAAACCTGGAGCTGGAG
AAGGACCTTCGAAAGAAAGCAGAGTCATTTGCACAAGAGATGTTCATTGAGCAAAACAAGCTAAAGAGACAAAGCCACCTTCTGCTGCAG
AGCTCCATCCCTGATCAGCAGCTTTTGAAAGCTTTAGACGAAAATGCAAAACTCACCCAGCAACTTGAAGAAGAGAGAATTCAGCATCAA
CAAAAGGTCAAAGAATTAGAAGAGCAACTAGAAAATGAAACACTCCACAAAGAAATACACAACCTCAAACAGCAACTGGAGCTTCTAGAG
GAAGATAAAAAGGAATTGGAATTGAAATATCAGAATTCTGAAGAGAAAGCCAGAAATTTAAAGCACTCTGTTGATGAACTCCAGAAACGA
GTGAACCAGTCTGAGAATTCAGTACCTCCACCACCTCCTCCTCCACCACCACTTCCCCCTCCACCTCCCAATCCTATCCGATCCCTCATG
TCCATGATCCGGAAACGATCCCACCCCAGTGGCAGTGGTGCTAAGAAAGAAAAGGCAACTCAACCAGAAACAACTGAAGAAGTCACAGAT
CTAAAGAGGCAAGCAGTTGAAGAGATGATGGATAGAATTAAAAAGGGAGTTCATCTTAGACCCGTTAATCAGACAGCCAGACCGAAGACA
AAGCCAGAATCTTCGAAAGGCTGCGAAAGTGCAGTGGATGAACTAAAAGGAATACTGGGGACACTTAACAAATCCACTAGTTCAAGAAGC
TTAAAATCCCTTGACCCTGAAAACAGTGAAACTGAGTTAGAAAGGATTTTGCGTCGCAGAAAGGTGACAGCAGAAGCAGATAGCAGTAGT
CCAACTGGGATATTAGCCACCTCAGAGTCCAAATCCATGCCAGTGTTGGGTTCTGTATCCAGTGTAACAAAAACAGCCTTGAACAAGAAA
ACTCTGGAGGCAGAATTCAACAGCCCGTCCCCCCCAACACCTGAGCCAGGTGAAGGGCCCCGTAAATTGGAAGGATGCACAAGTTCCAAG
GTTACGTTTCAGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAA
AGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCT
GAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCT
ACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGA
GTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGAC
ATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTA
AATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATC
CGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAA
GTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATA
CCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGG
GAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATG
TAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTC
TCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTA
TATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCC
TCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTC
ACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCA
GAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCT
TATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTC
AGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATC
TATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGC
TCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCAC
AATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAA
GCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGT
ACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGT
AAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGC
CTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTG

>42393_42393_2_KIAA1598-ATXN10_KIAA1598_chr10_118661276_ENST00000355371_ATXN10_chr22_46114293_ENST00000381061_length(amino acids)=843AA_BP=584
MLFLPPPPVCPAPLPLSLLFPAPPAKMNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE
EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSV
QEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNK
LKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNL
KHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLR
PVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSVS
SVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTK
DDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFS
NCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQ

--------------------------------------------------------------
>42393_42393_3_KIAA1598-ATXN10_KIAA1598_chr10_118661276_ENST00000392903_ATXN10_chr22_46114293_ENST00000252934_length(transcript)=4588nt_BP=2171nt
ATTGCGTCCCGCTCTACCTCTGTGGTTCTTTGGGAGCGACCCCCGGGAAGCGTCCAAAGTGGAGTTCCCACACACGCTGCGAACCCACAG
CCGGTTTTCTCTGAACTCGCGTCCCTGAGTCCGGGAGGTGGAGGCGGAGAAAAGGGTGCGGAGCGACCCCACGCAGGGCCGCCCCCCCTC
CCACCAGCGCGTCCTGCCGCGCCGGCAGCCACAGGCTGGCATAGCGGCTGCCGACCCGCCCTCGTTCCTCCACCCCCTGAACGGGACTGC
TGGGCCCGCCCCGCCCCGCCTGCAGGTGAAGCGGCCGCAGCCGCCGAGTAGGTGCGTGGGGATGATCTCACTCGCGCGCTCCGCGCCAGG
AGGAGGAGGAGCGGGAGCGGATCCAACTTCCGGGTAGTGGAGCCGCAAGCCACCGGCATCTTGCTTTTTCTTCCCCCTCCTCCTGTGTGC
CCCGCGCCGCTCCCTCTTTCCCTTTTATTCCCGGCCCCACCCGCCAAAATGAACAGCTCGGACGAAGAGAAGCAGCTGCAGCTCATTACC
AGTCTGAAGGAGCAAGCAATAGGCGAATATGAAGACCTTAGAGCAGAGAACCAGAAAACAAAGGAGAAGTGTGACAAAATTAGGCAAGAA
CGAGATGAAGCCGTTAAAAAACTGGAAGAATTTCAGAAAATTTCTCACATGGTCATAGAGGAAGTTAATTTCATGCAGAACCATCTTGAA
ATAGAGAAGACTTGTCGAGAAAGTGCTGAAGCTTTGGCAACAAAGCTAAATAAAGAAAATAAAACGTTGAAAAGAATCAGCATGTTGTAC
ATGGCCAAGCTGGGACCAGATGTAATAACTGAAGAGATAAACATTGATGATGAAGATTCGACTACAGACACAGACGGTGCCGCCGAGACT
TGTGTCTCAGTACAGTGTCAGAAGCAAATTAAAGAACTTCGAGATCAAATTGTATCTGTTCAGGAGGAAAAGAAGATTTTAGCCATTGAG
CTGGAAAATCTCAAGAGCAAACTCGTAGAAGTAATTGAAGAAGTAAATAAAGTTAAACAAGAAAAGACTGTTTTAAATTCAGAAGTTCTT
GAACAGAGAAAAGTCTTAGAAAAATGCAATAGAGTGTCCATGTTAGCTGTAGAAGAGTATGAGGAGATGCAAGTAAACCTGGAGCTGGAG
AAGGACCTTCGAAAGAAAGCAGAGTCATTTGCACAAGAGATGTTCATTGAGCAAAACAAGCTAAAGAGACAAAGCCACCTTCTGCTGCAG
AGCTCCATCCCTGATCAGCAGCTTTTGAAAGCTTTAGACGAAAATGCAAAACTCACCCAGCAACTTGAAGAAGAGAGAATTCAGCATCAA
CAAAAGGTCAAAGAATTAGAAGAGCAACTAGAAAATGAAACACTCCACAAAGAAATACACAACCTCAAACAGCAACTGGAGCTTCTAGAG
GAAGATAAAAAGGAATTGGAATTGAAATATCAGAATTCTGAAGAGAAAGCCAGAAATTTAAAGCACTCTGTTGATGAACTCCAGAAACGA
GTGAACCAGTCTGAGAATTCAGTACCTCCACCACCTCCTCCTCCACCACCACTTCCCCCTCCACCTCCCAATCCTATCCGATCCCTCATG
TCCATGATCCGGAAACGATCCCACCCCAGTGGCAGTGGTGCTAAGAAAGAAAAGGCAACTCAACCAGAAACAACTGAAGAAGTCACAGAT
CTAAAGAGGCAAGCAGTTGAAGAGATGATGGATAGAATTAAAAAGGGAGTTCATCTTAGACCCGTTAATCAGACAGCCAGACCGAAGACA
AAGCCAGAATCTTCGAAAGGCTGCGAAAGTGCAGTGGATGAACTAAAAGGAATACTGGGGACACTTAACAAATCCACTAGTTCAAGAAGC
TTAAAATCCCTTGACCCTGAAAACAGTGAAACTGAGTTAGAAAGGATTTTGCGTCGCAGAAAGGTGACAGCAGAAGCAGATAGCAGTAGT
CCAACTGGGATATTAGCCACCTCAGAGTCCAAATCCATGCCAGTGTTGGGTTCTGTATCCAGTGTAACAAAAACAGCCTTGAACAAGAAA
ACTCTGGAGGCAGAATTCAACAGCCCGTCCCCCCCAACACCTGAGCCAGGTGAAGGGCCCCGTAAATTGGAAGGATGCACAAGTTCCAAG
GTTACGTTTCAGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAA
AGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCT
GAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCT
ACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGA
GTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGAC
ATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTA
AATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATC
CGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAA
GTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATA
CCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGG
GAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATG
TAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTC
TCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTA
TATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCC
TCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTC
ACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCA
GAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCT
TATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTC
AGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATC
TATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGC
TCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCAC
AATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAA
GCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGT
ACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGT
AAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGC
CTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTG

>42393_42393_3_KIAA1598-ATXN10_KIAA1598_chr10_118661276_ENST00000392903_ATXN10_chr22_46114293_ENST00000252934_length(amino acids)=843AA_BP=584
MLFLPPPPVCPAPLPLSLLFPAPPAKMNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE
EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSV
QEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNK
LKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNL
KHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLR
PVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSVS
SVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTK
DDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFS
NCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQ

--------------------------------------------------------------
>42393_42393_4_KIAA1598-ATXN10_KIAA1598_chr10_118661276_ENST00000392903_ATXN10_chr22_46114293_ENST00000381061_length(transcript)=4585nt_BP=2171nt
ATTGCGTCCCGCTCTACCTCTGTGGTTCTTTGGGAGCGACCCCCGGGAAGCGTCCAAAGTGGAGTTCCCACACACGCTGCGAACCCACAG
CCGGTTTTCTCTGAACTCGCGTCCCTGAGTCCGGGAGGTGGAGGCGGAGAAAAGGGTGCGGAGCGACCCCACGCAGGGCCGCCCCCCCTC
CCACCAGCGCGTCCTGCCGCGCCGGCAGCCACAGGCTGGCATAGCGGCTGCCGACCCGCCCTCGTTCCTCCACCCCCTGAACGGGACTGC
TGGGCCCGCCCCGCCCCGCCTGCAGGTGAAGCGGCCGCAGCCGCCGAGTAGGTGCGTGGGGATGATCTCACTCGCGCGCTCCGCGCCAGG
AGGAGGAGGAGCGGGAGCGGATCCAACTTCCGGGTAGTGGAGCCGCAAGCCACCGGCATCTTGCTTTTTCTTCCCCCTCCTCCTGTGTGC
CCCGCGCCGCTCCCTCTTTCCCTTTTATTCCCGGCCCCACCCGCCAAAATGAACAGCTCGGACGAAGAGAAGCAGCTGCAGCTCATTACC
AGTCTGAAGGAGCAAGCAATAGGCGAATATGAAGACCTTAGAGCAGAGAACCAGAAAACAAAGGAGAAGTGTGACAAAATTAGGCAAGAA
CGAGATGAAGCCGTTAAAAAACTGGAAGAATTTCAGAAAATTTCTCACATGGTCATAGAGGAAGTTAATTTCATGCAGAACCATCTTGAA
ATAGAGAAGACTTGTCGAGAAAGTGCTGAAGCTTTGGCAACAAAGCTAAATAAAGAAAATAAAACGTTGAAAAGAATCAGCATGTTGTAC
ATGGCCAAGCTGGGACCAGATGTAATAACTGAAGAGATAAACATTGATGATGAAGATTCGACTACAGACACAGACGGTGCCGCCGAGACT
TGTGTCTCAGTACAGTGTCAGAAGCAAATTAAAGAACTTCGAGATCAAATTGTATCTGTTCAGGAGGAAAAGAAGATTTTAGCCATTGAG
CTGGAAAATCTCAAGAGCAAACTCGTAGAAGTAATTGAAGAAGTAAATAAAGTTAAACAAGAAAAGACTGTTTTAAATTCAGAAGTTCTT
GAACAGAGAAAAGTCTTAGAAAAATGCAATAGAGTGTCCATGTTAGCTGTAGAAGAGTATGAGGAGATGCAAGTAAACCTGGAGCTGGAG
AAGGACCTTCGAAAGAAAGCAGAGTCATTTGCACAAGAGATGTTCATTGAGCAAAACAAGCTAAAGAGACAAAGCCACCTTCTGCTGCAG
AGCTCCATCCCTGATCAGCAGCTTTTGAAAGCTTTAGACGAAAATGCAAAACTCACCCAGCAACTTGAAGAAGAGAGAATTCAGCATCAA
CAAAAGGTCAAAGAATTAGAAGAGCAACTAGAAAATGAAACACTCCACAAAGAAATACACAACCTCAAACAGCAACTGGAGCTTCTAGAG
GAAGATAAAAAGGAATTGGAATTGAAATATCAGAATTCTGAAGAGAAAGCCAGAAATTTAAAGCACTCTGTTGATGAACTCCAGAAACGA
GTGAACCAGTCTGAGAATTCAGTACCTCCACCACCTCCTCCTCCACCACCACTTCCCCCTCCACCTCCCAATCCTATCCGATCCCTCATG
TCCATGATCCGGAAACGATCCCACCCCAGTGGCAGTGGTGCTAAGAAAGAAAAGGCAACTCAACCAGAAACAACTGAAGAAGTCACAGAT
CTAAAGAGGCAAGCAGTTGAAGAGATGATGGATAGAATTAAAAAGGGAGTTCATCTTAGACCCGTTAATCAGACAGCCAGACCGAAGACA
AAGCCAGAATCTTCGAAAGGCTGCGAAAGTGCAGTGGATGAACTAAAAGGAATACTGGGGACACTTAACAAATCCACTAGTTCAAGAAGC
TTAAAATCCCTTGACCCTGAAAACAGTGAAACTGAGTTAGAAAGGATTTTGCGTCGCAGAAAGGTGACAGCAGAAGCAGATAGCAGTAGT
CCAACTGGGATATTAGCCACCTCAGAGTCCAAATCCATGCCAGTGTTGGGTTCTGTATCCAGTGTAACAAAAACAGCCTTGAACAAGAAA
ACTCTGGAGGCAGAATTCAACAGCCCGTCCCCCCCAACACCTGAGCCAGGTGAAGGGCCCCGTAAATTGGAAGGATGCACAAGTTCCAAG
GTTACGTTTCAGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAA
AGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCT
GAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCT
ACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGA
GTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGAC
ATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTA
AATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATC
CGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAA
GTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATA
CCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGG
GAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATG
TAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTC
TCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTA
TATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCC
TCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTC
ACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCA
GAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCT
TATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTC
AGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATC
TATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGC
TCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCAC
AATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAA
GCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGT
ACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGT
AAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGC
CTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTG

>42393_42393_4_KIAA1598-ATXN10_KIAA1598_chr10_118661276_ENST00000392903_ATXN10_chr22_46114293_ENST00000381061_length(amino acids)=843AA_BP=584
MLFLPPPPVCPAPLPLSLLFPAPPAKMNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE
EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSV
QEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNK
LKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNL
KHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLR
PVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERILRRRKVTAEADSSSPTGILATSESKSMPVLGSVS
SVTKTALNKKTLEAEFNSPSPPTPEPGEGPRKLEGCTSSKVTFQFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTK
DDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFS
NCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KIAA1598-ATXN10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIAA1598-ATXN10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIAA1598-ATXN10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0687120Nephronophthisis1GENOMICS_ENGLAND
TgeneC1963674Spinocerebellar Ataxia 101CTD_human;GENOMICS_ENGLAND;ORPHANET