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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:KIAA1967-FGFR2 (FusionGDB2 ID:HG57805TG2263) |
Fusion Gene Summary for KIAA1967-FGFR2 |
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Fusion gene information | Fusion gene name: KIAA1967-FGFR2 | Fusion gene ID: hg57805tg2263 | Hgene | Tgene | Gene symbol | KIAA1967 | FGFR2 | Gene ID | 57805 | 2263 |
Gene name | cell cycle and apoptosis regulator 2 | fibroblast growth factor receptor 2 | |
Synonyms | DBC-1|DBC1|KIAA1967|NET35|p30 DBC|p30DBC | BBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25 | |
Cytomap | ('CCAR2','KIAA1967')('FGFR2','FGFR2') 8p21.3 | 10q26.13 | |
Type of gene | protein-coding | protein-coding | |
Description | cell cycle and apoptosis regulator protein 2cell division cycle and apoptosis regulator protein 2deleted in breast cancer 1p30 DBC protein | fibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14 | |
Modification date | 20200313 | 20200322 | |
UniProtAcc | . | P21802 | |
Ensembl transtripts involved in fusion gene | ENST00000308511, ENST00000521301, ENST00000389279, ENST00000520861, | ENST00000520861, ENST00000521301, ENST00000308511, ENST00000389279, | |
Fusion gene scores | * DoF score | 4 X 4 X 5=80 | 11 X 11 X 8=968 |
# samples | 6 | 16 | |
** MAII score | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/968*10)=-2.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KIAA1967 [Title/Abstract] AND FGFR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CCAR2(22462355)-FGFR2(123239535), # samples:2 KIAA1967(22462355)-FGFR2(123239535), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | FGFR2-CCAR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FGFR2-CCAR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FGFR2-CCAR2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. FGFR2-CCAR2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FGFR2-CCAR2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. FGFR2-CCAR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. FGFR2-CCAR2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KIAA1967 | GO:0031647 | regulation of protein stability | 23398316 |
Hgene | KIAA1967 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 23398316 |
Hgene | KIAA1967 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process | 15824730 |
Hgene | KIAA1967 | GO:0045892 | negative regulation of transcription, DNA-templated | 20160719 |
Hgene | KIAA1967 | GO:0090311 | regulation of protein deacetylation | 21030595 |
Tgene | FGFR2 | GO:0008284 | positive regulation of cell proliferation | 8663044 |
Tgene | FGFR2 | GO:0008543 | fibroblast growth factor receptor signaling pathway | 8663044|15629145 |
Tgene | FGFR2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 15629145|16844695 |
Tgene | FGFR2 | GO:0046777 | protein autophosphorylation | 15629145 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUSC | TCGA-66-2765-01A | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
ChimerDB4 | LUSC | TCGA-66-2765 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
ChimerDB4 | LUSC | TCGA-66-2765 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
ChimerDB4 | LUSC | TCGA-66-2765-01A | KIAA1967 | chr8 | 22462355 | - | FGFR2 | chr10 | 123239535 | - |
ChimerDB4 | LUSC | TCGA-66-2765 | KIAA1967 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
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Fusion Gene ORF analysis for KIAA1967-FGFR2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000308511 | ENST00000369061 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-3CDS | ENST00000521301 | ENST00000369061 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000346997 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000346997 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000351936 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000351936 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000356226 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000356226 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000357555 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000357555 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000358487 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000358487 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000359354 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000359354 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000360144 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000360144 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000369056 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000369056 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000369059 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000369059 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000369060 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000369060 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000369061 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000457416 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000457416 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000478859 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000478859 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000308511 | ENST00000490349 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000308511 | ENST00000490349 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000346997 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000346997 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000351936 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000351936 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000356226 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000356226 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000357555 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000357555 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000358487 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000358487 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000359354 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000359354 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000360144 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000360144 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000369056 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000369056 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000369059 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000369059 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000369060 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000369060 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000369061 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000457416 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000457416 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000478859 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000478859 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
5UTR-intron | ENST00000521301 | ENST00000490349 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
5UTR-intron | ENST00000521301 | ENST00000490349 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-3CDS | ENST00000389279 | ENST00000369061 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-3CDS | ENST00000520861 | ENST00000369061 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000346997 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000346997 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000351936 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000351936 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000356226 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000356226 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000357555 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000357555 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000358487 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000358487 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000359354 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000359354 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000360144 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000360144 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000369056 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000369056 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000369059 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000369059 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000369060 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000369060 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000369061 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000457416 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000457416 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000478859 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000478859 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000389279 | ENST00000490349 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000389279 | ENST00000490349 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000346997 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000346997 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000351936 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000351936 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000356226 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000356226 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000357555 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000357555 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000358487 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000358487 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000359354 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000359354 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000360144 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000360144 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000369056 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000369056 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000369059 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000369059 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000369060 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000369060 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000369061 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000457416 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000457416 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000478859 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000478859 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
intron-intron | ENST00000520861 | ENST00000490349 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239535 | - |
intron-intron | ENST00000520861 | ENST00000490349 | CCAR2 | chr8 | 22462355 | + | FGFR2 | chr10 | 123239627 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for KIAA1967-FGFR2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for KIAA1967-FGFR2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:22462355/:123239535) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | FGFR2 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for KIAA1967-FGFR2 |
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Fusion Gene PPI Analysis for KIAA1967-FGFR2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KIAA1967-FGFR2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | FGFR2 | P21802 | DB00039 | Palifermin | Agonist|Binder | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB00039 | Palifermin | Agonist|Binder | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB00039 | Palifermin | Agonist|Binder | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB00039 | Palifermin | Agonist|Binder | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Tgene | FGFR2 | P21802 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Tgene | FGFR2 | P21802 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Tgene | FGFR2 | P21802 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Tgene | FGFR2 | P21802 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Tgene | FGFR2 | P21802 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Tgene | FGFR2 | P21802 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Tgene | FGFR2 | P21802 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Tgene | FGFR2 | P21802 | DB10770 | Foreskin fibroblast (neonatal) | Agonist | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB10770 | Foreskin fibroblast (neonatal) | Agonist | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB10770 | Foreskin fibroblast (neonatal) | Agonist | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB10770 | Foreskin fibroblast (neonatal) | Agonist | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB10772 | Foreskin keratinocyte (neonatal) | Agonist | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB10772 | Foreskin keratinocyte (neonatal) | Agonist | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB10772 | Foreskin keratinocyte (neonatal) | Agonist | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB10772 | Foreskin keratinocyte (neonatal) | Agonist | Biotech | Approved |
Tgene | FGFR2 | P21802 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Tgene | FGFR2 | P21802 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Tgene | FGFR2 | P21802 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Tgene | FGFR2 | P21802 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Tgene | FGFR2 | P21802 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | FGFR2 | P21802 | DB01041 | Thalidomide | Antagonist | Small molecule | Approved|Investigational|Withdrawn |
Tgene | FGFR2 | P21802 | DB01041 | Thalidomide | Antagonist | Small molecule | Approved|Investigational|Withdrawn |
Tgene | FGFR2 | P21802 | DB01041 | Thalidomide | Antagonist | Small molecule | Approved|Investigational|Withdrawn |
Tgene | FGFR2 | P21802 | DB01041 | Thalidomide | Antagonist | Small molecule | Approved|Investigational|Withdrawn |
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Related Diseases for KIAA1967-FGFR2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CCAR2 | C0043020 | Wallerian Degeneration | 1 | CTD_human |
Tgene | C2931196 | Craniofacial dysostosis type 1 | 23 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0220658 | Pfeiffer Syndrome | 21 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0001193 | Apert syndrome | 19 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0795998 | JACKSON-WEISS SYNDROME | 10 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0175699 | Saethre-Chotzen Syndrome | 8 | CTD_human;GENOMICS_ENGLAND;ORPHANET | |
Tgene | C1852406 | Cutis Gyrata Syndrome of Beare And Stevenson | 8 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C2936791 | Antley-Bixler Syndrome, Autosomal Dominant | 7 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C1510455 | Acrocephalosyndactylia | 6 | CTD_human;ORPHANET | |
Tgene | C0265269 | Lacrimoauriculodentodigital syndrome | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0010278 | Craniosynostosis | 4 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C1863389 | Apert-Crouzon Disease | 4 | CTD_human | |
Tgene | C1865070 | SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0006142 | Malignant neoplasm of breast | 3 | CTD_human;UNIPROT | |
Tgene | C0030044 | Acrocephaly | 3 | CTD_human | |
Tgene | C0036341 | Schizophrenia | 3 | PSYGENET | |
Tgene | C0221356 | Brachycephaly | 3 | CTD_human | |
Tgene | C0265534 | Scaphycephaly | 3 | CTD_human | |
Tgene | C0265535 | Trigonocephaly | 3 | CTD_human | |
Tgene | C0376634 | Craniofacial Abnormalities | 3 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 3 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 3 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 3 | CTD_human | |
Tgene | C1833340 | Synostotic Posterior Plagiocephaly | 3 | CTD_human | |
Tgene | C1860819 | Metopic synostosis | 3 | CTD_human | |
Tgene | C2931150 | Synostotic Anterior Plagiocephaly | 3 | CTD_human | |
Tgene | C3281247 | BENT BONE DYSPLASIA SYNDROME | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C4551902 | Craniosynostosis, Type 1 | 3 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 3 | CTD_human | |
Tgene | C0008925 | Cleft Palate | 2 | CTD_human | |
Tgene | C0011570 | Mental Depression | 2 | PSYGENET | |
Tgene | C0011581 | Depressive disorder | 2 | PSYGENET | |
Tgene | C0024623 | Malignant neoplasm of stomach | 2 | CGI;CTD_human | |
Tgene | C0038356 | Stomach Neoplasms | 2 | CGI;CTD_human | |
Tgene | C1708349 | Hereditary Diffuse Gastric Cancer | 2 | CTD_human | |
Tgene | C1837218 | Cleft palate, isolated | 2 | CTD_human | |
Tgene | C0000772 | Multiple congenital anomalies | 1 | CTD_human | |
Tgene | C0003090 | Ankylosis | 1 | CTD_human | |
Tgene | C0005586 | Bipolar Disorder | 1 | PSYGENET | |
Tgene | C0008924 | Cleft upper lip | 1 | CTD_human | |
Tgene | C0010273 | Craniofacial Dysostosis | 1 | CTD_human | |
Tgene | C0011757 | Developmental Coordination Disorder | 1 | CTD_human | |
Tgene | C0014170 | Endometrial Neoplasms | 1 | CTD_human | |
Tgene | C0018553 | Hamartoma Syndrome, Multiple | 1 | CTD_human | |
Tgene | C0020796 | Profound Mental Retardation | 1 | CTD_human | |
Tgene | C0023890 | Liver Cirrhosis | 1 | CTD_human | |
Tgene | C0024121 | Lung Neoplasms | 1 | CTD_human | |
Tgene | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human | |
Tgene | C0026613 | Motor Skills Disorders | 1 | CTD_human | |
Tgene | C0033975 | Psychotic Disorders | 1 | PSYGENET | |
Tgene | C0037268 | Skin Abnormalities | 1 | CTD_human | |
Tgene | C0037274 | Dermatologic disorders | 1 | CTD_human | |
Tgene | C0038219 | Status Dysraphicus | 1 | CTD_human | |
Tgene | C0040427 | Tooth Abnormalities | 1 | CTD_human | |
Tgene | C0080178 | Spina Bifida | 1 | CTD_human | |
Tgene | C0152423 | Congenital small ears | 1 | GENOMICS_ENGLAND | |
Tgene | C0206698 | Cholangiocarcinoma | 1 | CTD_human | |
Tgene | C0206762 | Limb Deformities, Congenital | 1 | CTD_human | |
Tgene | C0239946 | Fibrosis, Liver | 1 | CTD_human | |
Tgene | C0242379 | Malignant neoplasm of lung | 1 | CTD_human | |
Tgene | C0265326 | Bannayan-Riley-Ruvalcaba Syndrome | 1 | CTD_human | |
Tgene | C0266508 | Rachischisis | 1 | CTD_human | |
Tgene | C0345905 | Intrahepatic Cholangiocarcinoma | 1 | CTD_human | |
Tgene | C0349204 | Nonorganic psychosis | 1 | PSYGENET | |
Tgene | C0391826 | Lhermitte-Duclos disease | 1 | CTD_human | |
Tgene | C0476089 | Endometrial Carcinoma | 1 | CGI;CTD_human | |
Tgene | C0524730 | Odontome | 1 | CTD_human | |
Tgene | C0699791 | Stomach Carcinoma | 1 | CGI;GENOMICS_ENGLAND | |
Tgene | C0917816 | Mental deficiency | 1 | CTD_human | |
Tgene | C1450010 | Plagiocephaly, Nonsynostotic | 1 | CTD_human | |
Tgene | C1860042 | Antley-Bixler Syndrome with Disordered Steroidogenesis | 1 | CTD_human | |
Tgene | C1867564 | SCAPHOCEPHALY AND AXENFELD-RIEGER ANOMALY | 1 | GENOMICS_ENGLAND | |
Tgene | C1959582 | PTEN Hamartoma Tumor Syndrome | 1 | CTD_human | |
Tgene | C2350233 | Antley-Bixler Syndrome Phenotype | 1 | CTD_human | |
Tgene | C3267076 | Familial scaphocephaly syndrome | 1 | GENOMICS_ENGLAND | |
Tgene | C3714756 | Intellectual Disability | 1 | CTD_human | |
Tgene | C3805278 | Extrahepatic Cholangiocarcinoma | 1 | CTD_human |