![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CYP4F11-FAM95B1 (FusionGDB2 ID:HG57834TG100133036) |
Fusion Gene Summary for CYP4F11-FAM95B1 |
![]() |
Fusion gene information | Fusion gene name: CYP4F11-FAM95B1 | Fusion gene ID: hg57834tg100133036 | Hgene | Tgene | Gene symbol | CYP4F11 | FAM95B1 | Gene ID | 57834 | 100133036 |
Gene name | cytochrome P450 family 4 subfamily F member 11 | family with sequence similarity 95 member B1 | |
Synonyms | CYPIVF11 | - | |
Cytomap | ('CYP4F11')('FAM95B1') 19p13.12 | 9p11.2 | |
Type of gene | protein-coding | ncRNA | |
Description | cytochrome P450 4F113-hydroxy fatty acids omega-hydroxylase CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 11cytochrome P450, subfamily IVF, polypeptide 11docosahexaenoic acid omega-hydroxylaselong-chain fatty acid omega-monooxygenasephy | - | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9HBI6 | . | |
Ensembl transtripts involved in fusion gene | ENST00000248041, ENST00000326742, ENST00000402119, ENST00000591841, | ||
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CYP4F11 [Title/Abstract] AND FAM95B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CYP4F11(16038021)-FAM95B1(42470479), # samples:17 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CYP4F11 | GO:0006631 | fatty acid metabolic process | 18065749 |
Hgene | CYP4F11 | GO:0042361 | menaquinone catabolic process | 24138531 |
Hgene | CYP4F11 | GO:0042376 | phylloquinone catabolic process | 24138531 |
Hgene | CYP4F11 | GO:0042377 | vitamin K catabolic process | 24138531 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ESCA | TCGA-IG-A8O2 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-JY-A6FA | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-L5-A88Z | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-LN-A4MQ | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-LN-A5U7 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-LN-A7HZ | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-LN-A8HZ | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-LN-A8I0 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-LN-A8I1 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-LN-A9FQ | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-LN-A9FR | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-V5-A7RC | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-VR-A8ER | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-VR-A8EZ | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | ESCA | TCGA-XP-A8T6 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
ChimerDB4 | OV | TCGA-WR-A838 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
Top |
Fusion Gene ORF analysis for CYP4F11-FAM95B1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000248041 | ENST00000592873 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
5CDS-3UTR | ENST00000326742 | ENST00000592873 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
5CDS-3UTR | ENST00000402119 | ENST00000592873 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
5UTR-3UTR | ENST00000591841 | ENST00000592873 | CYP4F11 | chr19 | 16038021 | - | FAM95B1 | chr9 | 42470479 | + |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for CYP4F11-FAM95B1 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Top |
Fusion Protein Features for CYP4F11-FAM95B1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:16038021/:42470479) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
CYP4F11 | . |
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:24138531, PubMed:15364545, PubMed:18065749). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545). {ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:19932081, ECO:0000269|PubMed:24138531}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for CYP4F11-FAM95B1 |
![]() |
Top |
Fusion Gene PPI Analysis for CYP4F11-FAM95B1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for CYP4F11-FAM95B1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for CYP4F11-FAM95B1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |