Fusion gene information | Fusion gene name: ARID4A-PSMA3 |
Fusion gene ID: hg5926tg5684 | | Hgene | Tgene | Gene symbol | ARID4A | PSMA3 | Gene ID | 5926 | 5684 | Gene name | AT-rich interaction domain 4A | proteasome 20S subunit alpha 3 |
Synonyms | RBBP-1|RBBP1|RBP-1|RBP1 | HC8|PSC3 |
Cytomap | ('ARID4A')('PSMA3') 14q23.1 | 14q23.1 |
Type of gene | protein-coding | protein-coding |
Description | AT-rich interactive domain-containing protein 4AARID domain-containing protein 4AAT rich interactive domain 4A (RBP1-like)retinoblastoma-binding protein 1 | proteasome subunit alpha type-3macropain subunit C8multicatalytic endopeptidase complex subunit C8proteasome (prosome, macropain) subunit, alpha type, 3proteasome component C8proteasome subunit C8proteasome subunit alpha 3proteasome subunit alpha7 |
Modification date | 20200320 | 20200327 |
UniProtAcc | . | . |
Ensembl transtripts involved in fusion gene | ENST00000348476, ENST00000355431, ENST00000395168, ENST00000431317, ENST00000553355, | |
Fusion gene scores | * DoF score | 8 X 8 X 5=320 | 11 X 10 X 2=220 |
# samples | 9 | 11 |
** MAII score | log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/220*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 |
Context | PubMed: ARID4A [Title/Abstract] AND PSMA3 [Title/Abstract] AND fusion [Title/Abstract] |
Most frequent breakpoint | ARID4A(58772831)-PSMA3(58730422), # samples:1
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Anticipated loss of major functional domain due to fusion event. | ARID4A-PSMA3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. ARID4A-PSMA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ARID4A-PSMA3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ARID4A-PSMA3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
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Hgene | Tgene |
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FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |