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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACE2-GPR143 (FusionGDB2 ID:HG59272TG4935) |
Fusion Gene Summary for ACE2-GPR143 |
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Fusion gene information | Fusion gene name: ACE2-GPR143 | Fusion gene ID: hg59272tg4935 | Hgene | Tgene | Gene symbol | ACE2 | GPR143 | Gene ID | 59272 | 4935 |
Gene name | angiotensin I converting enzyme 2 | G protein-coupled receptor 143 | |
Synonyms | ACEH | NYS6|OA1 | |
Cytomap | ('ACE2')('GPR143') Xp22.2 | Xp22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | angiotensin-converting enzyme 2ACE-related carboxypeptidaseangiotensin I converting enzyme (peptidyl-dipeptidase A) 2angiotensin-converting enzyme homologmetalloprotease MPROT15peptidyl-dipeptidase A | G-protein coupled receptor 143ocular albinism 1ocular albinism type 1 protein | |
Modification date | 20200322 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000252519, ENST00000427411, ENST00000471548, | ||
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACE2 [Title/Abstract] AND GPR143 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACE2(15596212)-GPR143(9693880), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | ACE2-GPR143 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACE2-GPR143 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACE2-GPR143 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACE2-GPR143 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACE2-GPR143 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ACE2-GPR143 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ACE2-GPR143 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACE2 | GO:0046813 | receptor-mediated virion attachment to host cell | 18343844 |
Tgene | GPR143 | GO:0007186 | G protein-coupled receptor signaling pathway | 16524428 |
Tgene | GPR143 | GO:0032400 | melanosome localization | 19717472 |
Tgene | GPR143 | GO:0032402 | melanosome transport | 19717472 |
Tgene | GPR143 | GO:0035584 | calcium-mediated signaling using intracellular calcium source | 18828673 |
Tgene | GPR143 | GO:0048015 | phosphatidylinositol-mediated signaling | 16524428 |
Tgene | GPR143 | GO:0050848 | regulation of calcium-mediated signaling | 18828673 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | COAD | TCGA-AZ-6605-01A | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
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Fusion Gene ORF analysis for ACE2-GPR143 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000252519 | ENST00000487206 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
5CDS-intron | ENST00000427411 | ENST00000487206 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
Frame-shift | ENST00000252519 | ENST00000467482 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
Frame-shift | ENST00000427411 | ENST00000380929 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
In-frame | ENST00000252519 | ENST00000380929 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
In-frame | ENST00000427411 | ENST00000467482 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
intron-3CDS | ENST00000471548 | ENST00000380929 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
intron-3CDS | ENST00000471548 | ENST00000467482 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
intron-intron | ENST00000471548 | ENST00000487206 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000252519 | ACE2 | chrX | 15596212 | - | ENST00000380929 | GPR143 | chrX | 9693880 | - | 1827 | 1400 | 103 | 1494 | 463 |
ENST00000427411 | ACE2 | chrX | 15596212 | - | ENST00000467482 | GPR143 | chrX | 9693880 | - | 2009 | 1514 | 217 | 1608 | 463 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000252519 | ENST00000380929 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - | 0.000304618 | 0.9996954 |
ENST00000427411 | ENST00000467482 | ACE2 | chrX | 15596212 | - | GPR143 | chrX | 9693880 | - | 0.000228373 | 0.99977165 |
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Fusion Genomic Features for ACE2-GPR143 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ACE2-GPR143 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:15596212/chrX:9693880) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 345_346 | 432 | 806.0 | Region | Substrate binding |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 345_346 | 432 | 806.0 | Region | Substrate binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 778_786 | 432 | 806.0 | Motif | LIR |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 781_784 | 432 | 806.0 | Motif | Endocytic sorting signal |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 781_785 | 432 | 806.0 | Motif | SH2-binding |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 792_795 | 432 | 806.0 | Motif | PTB |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 803_805 | 432 | 806.0 | Motif | PDZ-binding |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 778_786 | 432 | 806.0 | Motif | LIR |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 781_784 | 432 | 806.0 | Motif | Endocytic sorting signal |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 781_785 | 432 | 806.0 | Motif | SH2-binding |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 792_795 | 432 | 806.0 | Motif | PTB |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 803_805 | 432 | 806.0 | Motif | PDZ-binding |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 652_659 | 432 | 806.0 | Region | Essential for cleavage by ADAM17 |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 697_716 | 432 | 806.0 | Region | Essential for cleavage by TMPRSS11D and TMPRSS2 |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 652_659 | 432 | 806.0 | Region | Essential for cleavage by ADAM17 |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 697_716 | 432 | 806.0 | Region | Essential for cleavage by TMPRSS11D and TMPRSS2 |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 18_740 | 432 | 806.0 | Topological domain | Extracellular |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 762_805 | 432 | 806.0 | Topological domain | Cytoplasmic |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 18_740 | 432 | 806.0 | Topological domain | Extracellular |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 762_805 | 432 | 806.0 | Topological domain | Cytoplasmic |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 741_761 | 432 | 806.0 | Transmembrane | Helical |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 741_761 | 432 | 806.0 | Transmembrane | Helical |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 222_231 | 393 | 425.0 | Motif | Note=lysosomal/melanosomal membrane localization signal | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 222_231 | 373 | 405.0 | Motif | Note=lysosomal/melanosomal membrane localization signal | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 221_238 | 393 | 425.0 | Region | Note=Necessary for its G protein-activation ability and normal distribution of melanosomes | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 221_238 | 373 | 405.0 | Region | Note=Necessary for its G protein-activation ability and normal distribution of melanosomes | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 100_124 | 393 | 425.0 | Topological domain | Extracellular | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 146_149 | 393 | 425.0 | Topological domain | Cytoplasmic | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 171_191 | 393 | 425.0 | Topological domain | Extracellular | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 1_28 | 393 | 425.0 | Topological domain | Extracellular | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 213_248 | 393 | 425.0 | Topological domain | Cytoplasmic | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 270_292 | 393 | 425.0 | Topological domain | Extracellular | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 314_404 | 393 | 425.0 | Topological domain | Cytoplasmic | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 50_78 | 393 | 425.0 | Topological domain | Cytoplasmic | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 100_124 | 373 | 405.0 | Topological domain | Extracellular | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 146_149 | 373 | 405.0 | Topological domain | Cytoplasmic | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 171_191 | 373 | 405.0 | Topological domain | Extracellular | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 1_28 | 373 | 405.0 | Topological domain | Extracellular | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 213_248 | 373 | 405.0 | Topological domain | Cytoplasmic | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 270_292 | 373 | 405.0 | Topological domain | Extracellular | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 314_404 | 373 | 405.0 | Topological domain | Cytoplasmic | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 50_78 | 373 | 405.0 | Topological domain | Cytoplasmic | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 125_145 | 393 | 425.0 | Transmembrane | Helical%3B Name%3D3 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 150_170 | 393 | 425.0 | Transmembrane | Helical%3B Name%3D4 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 192_212 | 393 | 425.0 | Transmembrane | Helical%3B Name%3D5 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 249_269 | 393 | 425.0 | Transmembrane | Helical%3B Name%3D6 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 293_313 | 393 | 425.0 | Transmembrane | Helical%3B Name%3D7 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 29_49 | 393 | 425.0 | Transmembrane | Helical%3B Name%3D1 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000380929 | 7 | 9 | 79_99 | 393 | 425.0 | Transmembrane | Helical%3B Name%3D2 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 125_145 | 373 | 405.0 | Transmembrane | Helical%3B Name%3D3 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 150_170 | 373 | 405.0 | Transmembrane | Helical%3B Name%3D4 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 192_212 | 373 | 405.0 | Transmembrane | Helical%3B Name%3D5 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 249_269 | 373 | 405.0 | Transmembrane | Helical%3B Name%3D6 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 293_313 | 373 | 405.0 | Transmembrane | Helical%3B Name%3D7 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 29_49 | 373 | 405.0 | Transmembrane | Helical%3B Name%3D1 | |
Tgene | GPR143 | chrX:15596212 | chrX:9693880 | ENST00000467482 | 7 | 9 | 79_99 | 373 | 405.0 | Transmembrane | Helical%3B Name%3D2 |
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Fusion Gene Sequence for ACE2-GPR143 |
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>1276_1276_1_ACE2-GPR143_ACE2_chrX_15596212_ENST00000252519_GPR143_chrX_9693880_ENST00000380929_length(transcript)=1827nt_BP=1400nt CGCCCAACCCAAGTTCAAAGGCTGATAAGAGAGAAAATCTCATGAGGAGGTTTTAGTCTAGGGAAAGTCATTCAGTGGATGTGATCTTGG CTCACAGGGGACGATGTCAAGCTCTTCCTGGCTCCTTCTCAGCCTTGTTGCTGTAACTGCTGCTCAGTCCACCATTGAGGAACAGGCCAA GACATTTTTGGACAAGTTTAACCACGAAGCCGAAGACCTGTTCTATCAAAGTTCACTTGCTTCTTGGAATTATAACACCAATATTACTGA AGAGAATGTCCAAAACATGAATAATGCTGGGGACAAATGGTCTGCCTTTTTAAAGGAACAGTCCACACTTGCCCAAATGTATCCACTACA AGAAATTCAGAATCTCACAGTCAAGCTTCAGCTGCAGGCTCTTCAGCAAAATGGGTCTTCAGTGCTCTCAGAAGACAAGAGCAAACGGTT GAACACAATTCTAAATACAATGAGCACCATCTACAGTACTGGAAAAGTTTGTAACCCAGATAATCCACAAGAATGCTTATTACTTGAACC AGGTTTGAATGAAATAATGGCAAACAGTTTAGACTACAATGAGAGGCTCTGGGCTTGGGAAAGCTGGAGATCTGAGGTCGGCAAGCAGCT GAGGCCATTATATGAAGAGTATGTGGTCTTGAAAAATGAGATGGCAAGAGCAAATCATTATGAGGACTATGGGGATTATTGGAGAGGAGA CTATGAAGTAAATGGGGTAGATGGCTATGACTACAGCCGCGGCCAGTTGATTGAAGATGTGGAACATACCTTTGAAGAGATTAAACCATT ATATGAACATCTTCATGCCTATGTGAGGGCAAAGTTGATGAATGCCTATCCTTCCTATATCAGTCCAATTGGATGCCTCCCTGCTCATTT GCTTGGTGATATGTGGGGTAGATTTTGGACAAATCTGTACTCTTTGACAGTTCCCTTTGGACAGAAACCAAACATAGATGTTACTGATGC AATGGTGGACCAGGCCTGGGATGCACAGAGAATATTCAAGGAGGCCGAGAAGTTCTTTGTATCTGTTGGTCTTCCTAATATGACTCAAGG ATTCTGGGAAAATTCCATGCTAACGGACCCAGGAAATGTTCAGAAAGCAGTCTGCCATCCCACAGCTTGGGACCTGGGGAAGGGCGACTT CAGGATCCTTATGTGCACAAAGGTGACAATGGACGACTTCCTGACAGCTCATCATGAGATGGGGCATATCCAGTATGATATGGCATATGC TGCACAACCTTTTCTGCTAAGAAATGGAGCTAATGAAGGATTCCATGAAGCTGTTGGGGAAATCATGTCACTTTCTGCAGCCACACCTAA GCATTTAAAATCCATTGGTCTTCTGTCACCCGATTTTCAAGAAGACAATGGTTCTGATGCCAGCACAATTGAAATTCACACTGCAAGTGA ATCCTGCAACAAAAATGAGGGTGACCCTGCTCTCCCAACCCATGGAGACCTATGAAGGGGATGTGCTGGGGGTCCAGACCCCATATTCCT CAGACTCAACAATTCTTGTTCTTTAGAACTGTGTTCTCACCTTCCCAACACTGCACTGCCGAAGTGTAGCGGCCCCCAAACCTTGCTCTC ATCACCAGCTAGAGCTTCTTCCCGAAGGGCCTTTAGGATAGGAGAAAGGGTTCATGCACACACGTGTGAGAATGGAAGAGCCCCCTCCAG ACCACTCTACAGCTGCTCTAGCCTTAGTTGCCACTAGGAAGTTTTCTGAGGCTGGCTGTAAAGTAAGTGTAAGGTCCACATCCTTGGGGA >1276_1276_1_ACE2-GPR143_ACE2_chrX_15596212_ENST00000252519_GPR143_chrX_9693880_ENST00000380929_length(amino acids)=463AA_BP=432 MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQN LTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDM WGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILM CTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNGSDASTIEIHTASESCNK -------------------------------------------------------------- >1276_1276_2_ACE2-GPR143_ACE2_chrX_15596212_ENST00000427411_GPR143_chrX_9693880_ENST00000467482_length(transcript)=2009nt_BP=1514nt GTTGTTGTGATCCCATGGCTACAGAGGATCAGGAGTTGACATAGATACTCTTTGGATTTCATACCATGTGGAGGCTTTCTTACTTCCACG TGACCTTGACTGAGTTTTGAATAGCGCCCAACCCAAGTTCAAAGGCTGATAAGAGAGAAAATCTCATGAGGAGGTTTTAGTCTAGGGAAA GTCATTCAGTGGATGTGATCTTGGCTCACAGGGGACGATGTCAAGCTCTTCCTGGCTCCTTCTCAGCCTTGTTGCTGTAACTGCTGCTCA GTCCACCATTGAGGAACAGGCCAAGACATTTTTGGACAAGTTTAACCACGAAGCCGAAGACCTGTTCTATCAAAGTTCACTTGCTTCTTG GAATTATAACACCAATATTACTGAAGAGAATGTCCAAAACATGAATAATGCTGGGGACAAATGGTCTGCCTTTTTAAAGGAACAGTCCAC ACTTGCCCAAATGTATCCACTACAAGAAATTCAGAATCTCACAGTCAAGCTTCAGCTGCAGGCTCTTCAGCAAAATGGGTCTTCAGTGCT CTCAGAAGACAAGAGCAAACGGTTGAACACAATTCTAAATACAATGAGCACCATCTACAGTACTGGAAAAGTTTGTAACCCAGATAATCC ACAAGAATGCTTATTACTTGAACCAGGTTTGAATGAAATAATGGCAAACAGTTTAGACTACAATGAGAGGCTCTGGGCTTGGGAAAGCTG GAGATCTGAGGTCGGCAAGCAGCTGAGGCCATTATATGAAGAGTATGTGGTCTTGAAAAATGAGATGGCAAGAGCAAATCATTATGAGGA CTATGGGGATTATTGGAGAGGAGACTATGAAGTAAATGGGGTAGATGGCTATGACTACAGCCGCGGCCAGTTGATTGAAGATGTGGAACA TACCTTTGAAGAGATTAAACCATTATATGAACATCTTCATGCCTATGTGAGGGCAAAGTTGATGAATGCCTATCCTTCCTATATCAGTCC AATTGGATGCCTCCCTGCTCATTTGCTTGGTGATATGTGGGGTAGATTTTGGACAAATCTGTACTCTTTGACAGTTCCCTTTGGACAGAA ACCAAACATAGATGTTACTGATGCAATGGTGGACCAGGCCTGGGATGCACAGAGAATATTCAAGGAGGCCGAGAAGTTCTTTGTATCTGT TGGTCTTCCTAATATGACTCAAGGATTCTGGGAAAATTCCATGCTAACGGACCCAGGAAATGTTCAGAAAGCAGTCTGCCATCCCACAGC TTGGGACCTGGGGAAGGGCGACTTCAGGATCCTTATGTGCACAAAGGTGACAATGGACGACTTCCTGACAGCTCATCATGAGATGGGGCA TATCCAGTATGATATGGCATATGCTGCACAACCTTTTCTGCTAAGAAATGGAGCTAATGAAGGATTCCATGAAGCTGTTGGGGAAATCAT GTCACTTTCTGCAGCCACACCTAAGCATTTAAAATCCATTGGTCTTCTGTCACCCGATTTTCAAGAAGACAATGGTTCTGATGCCAGCAC AATTGAAATTCACACTGCAAGTGAATCCTGCAACAAAAATGAGGGTGACCCTGCTCTCCCAACCCATGGAGACCTATGAAGGGGATGTGC TGGGGGTCCAGACCCCATATTCCTCAGACTCAACAATTCTTGTTCTTTAGAACTGTGTTCTCACCTTCCCAACACTGCACTGCCGAAGTG TAGCGGCCCCCAAACCTTGCTCTCATCACCAGCTAGAGCTTCTTCCCGAAGGGCCTTTAGGATAGGAGAAAGGGTTCATGCACACACGTG TGAGAATGGAAGAGCCCCCTCCAGACCACTCTACAGCTGCTCTAGCCTTAGTTGCCACTAGGAAGTTTTCTGAGGCTGGCTGTAAAGTAA GTGTAAGGTCCACATCCTTGGGGAAGTAGTTAAATAAAATAGTTATGACTGAGCTCTCAGCCTGACTTGGATTCTGTCTTAACACTTCTA >1276_1276_2_ACE2-GPR143_ACE2_chrX_15596212_ENST00000427411_GPR143_chrX_9693880_ENST00000467482_length(amino acids)=463AA_BP=432 MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQN LTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDM WGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILM CTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNGSDASTIEIHTASESCNK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACE2-GPR143 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 30_41 | 432.3333333333333 | 806.0 | SARS-CoV spike glycoprotein |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000252519 | - | 9 | 18 | 353_357 | 432.3333333333333 | 806.0 | SARS-CoV spike glycoprotein |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 30_41 | 432.3333333333333 | 806.0 | SARS-CoV spike glycoprotein |
Hgene | ACE2 | chrX:15596212 | chrX:9693880 | ENST00000427411 | - | 10 | 19 | 353_357 | 432.3333333333333 | 806.0 | SARS-CoV spike glycoprotein |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACE2-GPR143 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACE2-GPR143 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACE2 | C0020538 | Hypertensive disease | 4 | CTD_human |
Hgene | ACE2 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Hgene | ACE2 | C0000822 | Abortion, Tubal | 1 | CTD_human |
Hgene | ACE2 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Hgene | ACE2 | C0017667 | Nodular glomerulosclerosis | 1 | CTD_human |
Hgene | ACE2 | C0162871 | Aortic Aneurysm, Abdominal | 1 | CTD_human |
Hgene | ACE2 | C0553980 | Endomyocardial Fibrosis | 1 | CTD_human |
Hgene | ACE2 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
Hgene | ACE2 | C3830362 | Early Pregnancy Loss | 1 | CTD_human |
Hgene | ACE2 | C4552766 | Miscarriage | 1 | CTD_human |
Tgene | C0342684 | Ocular albinism, type I | 14 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C3151752 | NYSTAGMUS 6, CONGENITAL, X-LINKED | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0015397 | Disorder of eye | 1 | GENOMICS_ENGLAND | |
Tgene | C0028738 | Nystagmus | 1 | GENOMICS_ENGLAND | |
Tgene | C1963184 | Nystagmus, CTCAE 3.0 | 1 | GENOMICS_ENGLAND | |
Tgene | C4554036 | Nystagmus, CTCAE 5.0 | 1 | GENOMICS_ENGLAND |