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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SENP2-ABR (FusionGDB2 ID:HG59343TG29)

Fusion Gene Summary for SENP2-ABR

check button Fusion gene summary
Fusion gene informationFusion gene name: SENP2-ABR
Fusion gene ID: hg59343tg29
HgeneTgene
Gene symbol

SENP2

ABR

Gene ID

59343

29

Gene nameSUMO specific peptidase 2ABR activator of RhoGEF and GTPase
SynonymsAXAM2|SMT3IP2MDB
Cytomap('SENP2')('ABR')

3q27.2

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionsentrin-specific protease 2SMT3-specific isopeptidase 2SUMO1/sentrin/SMT3 specific peptidase 2SUMO1/sentrin/SMT3 specific protease 2sentrin (SUMO1) specific peptidase 2sentrin/SUMO-specific protease SENP2active breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-related
Modification date2020031320200313
UniProtAcc.

Q12979

Ensembl transtripts involved in fusion geneENST00000465201, ENST00000296257, 
ENST00000545472, ENST00000427465, 
Fusion gene scores* DoF score13 X 12 X 10=156017 X 14 X 9=2142
# samples 1621
** MAII scorelog2(16/1560*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2142*10)=-3.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SENP2 [Title/Abstract] AND ABR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSENP2(185307957)-ABR(915225), # samples:3
Anticipated loss of major functional domain due to fusion event.SENP2-ABR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SENP2-ABR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSENP2

GO:0016926

protein desumoylation

20194620

HgeneSENP2

GO:0031397

negative regulation of protein ubiquitination

22028379

TgeneABR

GO:0090630

activation of GTPase activity

7479768



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A6B2-01ASENP2chr3

185307957

-ABRchr17

915225

-
ChimerDB4BLCATCGA-DK-A6B2-01ASENP2chr3

185307957

+ABRchr17

915225

-


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Fusion Gene ORF analysis for SENP2-ABR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000465201ENST00000291107SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000302538SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000536794SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000543210SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000544583SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000572441SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000574437SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-intronENST00000465201ENST00000573895SENP2chr3

185307957

+ABRchr17

915225

-
5CDS-intronENST00000296257ENST00000573895SENP2chr3

185307957

+ABRchr17

915225

-
5CDS-intronENST00000545472ENST00000573895SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000291107SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000302538SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000536794SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000543210SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000544583SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000572441SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000574437SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-intronENST00000427465ENST00000573895SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000291107SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000302538SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000536794SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000543210SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000544583SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000572441SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000574437SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000291107SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000302538SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000536794SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000543210SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000544583SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000572441SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000574437SENP2chr3

185307957

+ABRchr17

915225

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SENP2-ABR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for SENP2-ABR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:185307957/:915225)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABR

Q12979

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SENP2-ABR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SENP2-ABR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SENP2-ABR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SENP2-ABR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSENP2C0019193Hepatitis, Toxic1CTD_human
HgeneSENP2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSENP2C0860207Drug-Induced Liver Disease1CTD_human
HgeneSENP2C1262760Hepatitis, Drug-Induced1CTD_human
HgeneSENP2C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneSENP2C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneSENP2C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human