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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCND1-TACSTD2 (FusionGDB2 ID:HG595TG4070)

Fusion Gene Summary for CCND1-TACSTD2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCND1-TACSTD2
Fusion gene ID: hg595tg4070
HgeneTgene
Gene symbol

CCND1

TACSTD2

Gene ID

595

4070

Gene namecyclin D1tumor associated calcium signal transducer 2
SynonymsBCL1|D11S287E|PRAD1|U21B31EGP-1|EGP1|GA733-1|GA7331|GP50|M1S1|TROP2
Cytomap('CCND1')('TACSTD2')

11q13.3

1p32.1

Type of geneprotein-codingprotein-coding
DescriptionG1/S-specific cyclin-D1B-cell CLL/lymphoma 1B-cell lymphoma 1 proteinBCL-1 oncogenePRAD1 oncogenetumor-associated calcium signal transducer 240kD glycoprotein, identified by monoclonal antibody GA733cell surface glycoprotein TROP2cell surface glycoprotein Trop-2epithelial glycoprotein-1gastrointestinal tumor-associated antigen GA7331membrane co
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000227507, ENST00000536559, 
Fusion gene scores* DoF score13 X 15 X 8=15603 X 5 X 2=30
# samples 155
** MAII scorelog2(15/1560*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCND1 [Title/Abstract] AND TACSTD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCND1(69466276)-TACSTD2(59042897), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCND1

GO:0000082

G1/S transition of mitotic cell cycle

19412162

HgeneCCND1

GO:0000122

negative regulation of transcription by RNA polymerase II

16569215|18417529

HgeneCCND1

GO:0001934

positive regulation of protein phosphorylation

8114739

HgeneCCND1

GO:0006974

cellular response to DNA damage stimulus

19412162

HgeneCCND1

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

19124461

HgeneCCND1

GO:0031571

mitotic G1 DNA damage checkpoint

19412162

HgeneCCND1

GO:0044321

response to leptin

17344214

HgeneCCND1

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

8114739

HgeneCCND1

GO:0070141

response to UV-A

18483258

HgeneCCND1

GO:0071157

negative regulation of cell cycle arrest

19124461



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4adenocarcinomaX77754CCND1chr11

69466276

TACSTD2chr1

59041101



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Fusion Gene ORF analysis for CCND1-TACSTD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000227507ENST00000371225CCND1chr11

69466276

TACSTD2chr1

59041101

intron-intronENST00000536559ENST00000371225CCND1chr11

69466276

TACSTD2chr1

59041101


check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CCND1-TACSTD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CCND1-TACSTD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69466276/:59042897)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CCND1-TACSTD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CCND1-TACSTD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCND1-TACSTD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCND1-TACSTD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCND1C0006142Malignant neoplasm of breast6CTD_human
HgeneCCND1C0678222Breast Carcinoma6CTD_human
HgeneCCND1C1257931Mammary Neoplasms, Human6CTD_human
HgeneCCND1C1458155Mammary Neoplasms6CTD_human
HgeneCCND1C4704874Mammary Carcinoma, Human6CTD_human
HgeneCCND1C2239176Liver carcinoma5CTD_human
HgeneCCND1C0007097Carcinoma4CTD_human
HgeneCCND1C0007102Malignant tumor of colon4CTD_human
HgeneCCND1C0009375Colonic Neoplasms4CTD_human
HgeneCCND1C0024667Animal Mammary Neoplasms4CTD_human
HgeneCCND1C0205696Anaplastic carcinoma4CTD_human
HgeneCCND1C0205697Carcinoma, Spindle-Cell4CTD_human
HgeneCCND1C0205698Undifferentiated carcinoma4CTD_human
HgeneCCND1C0205699Carcinomatosis4CTD_human
HgeneCCND1C1257925Mammary Carcinoma, Animal4CTD_human
HgeneCCND1C0024668Mammary Neoplasms, Experimental3CTD_human
HgeneCCND1C0006118Brain Neoplasms2CTD_human
HgeneCCND1C0007621Neoplastic Cell Transformation2CTD_human
HgeneCCND1C0020507Hyperplasia2CTD_human
HgeneCCND1C0024121Lung Neoplasms2CTD_human
HgeneCCND1C0153633Malignant neoplasm of brain2CTD_human
HgeneCCND1C0242379Malignant neoplasm of lung2CTD_human
HgeneCCND1C0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse2CTD_human
HgeneCCND1C0496899Benign neoplasm of brain, unspecified2CTD_human
HgeneCCND1C0750974Brain Tumor, Primary2CTD_human
HgeneCCND1C0750977Recurrent Brain Neoplasm2CTD_human
HgeneCCND1C0750979Primary malignant neoplasm of brain2CTD_human
HgeneCCND1C0751958Lymphoma, Lymphocytic, Intermediate2CTD_human
HgeneCCND1C1168401Squamous cell carcinoma of the head and neck2CTD_human
HgeneCCND1C1527390Neoplasms, Intracranial2CTD_human
HgeneCCND1C0001418Adenocarcinoma1CTD_human
HgeneCCND1C0006079Bowen's Disease1CTD_human
HgeneCCND1C0007137Squamous cell carcinoma1CTD_human
HgeneCCND1C0007138Carcinoma, Transitional Cell1CTD_human
HgeneCCND1C0007528Cecal Neoplasms1CTD_human
HgeneCCND1C0007873Uterine Cervical Neoplasm1CTD_human
HgeneCCND1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneCCND1C0014170Endometrial Neoplasms1CTD_human
HgeneCCND1C0014859Esophageal Neoplasms1CTD_human
HgeneCCND1C0018923Hemangiosarcoma1CTD_human
HgeneCCND1C0019207Hepatoma, Morris1CTD_human
HgeneCCND1C0019208Hepatoma, Novikoff1CTD_human
HgeneCCND1C0020502Hyperparathyroidism1CTD_human
HgeneCCND1C0021846Intestinal Polyps1CTD_human
HgeneCCND1C0022665Kidney Neoplasm1CTD_human
HgeneCCND1C0023418leukemia1CTD_human
HgeneCCND1C0023903Liver neoplasms1CTD_human
HgeneCCND1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneCCND1C0024623Malignant neoplasm of stomach1CTD_human
HgeneCCND1C0026764Multiple Myeloma1CTD_human;ORPHANET
HgeneCCND1C0027659Neoplasms, Experimental1CTD_human
HgeneCCND1C0030354Papilloma1CTD_human
HgeneCCND1C0032927Precancerous Conditions1CTD_human
HgeneCCND1C0033578Prostatic Neoplasms1CTD_human
HgeneCCND1C0036095Salivary Gland Neoplasms1CTD_human
HgeneCCND1C0036341Schizophrenia1PSYGENET
HgeneCCND1C0038356Stomach Neoplasms1CTD_human
HgeneCCND1C0040136Thyroid Neoplasm1CTD_human
HgeneCCND1C0041696Unipolar Depression1PSYGENET
HgeneCCND1C0042076Urologic Neoplasms1CTD_human
HgeneCCND1C0086404Experimental Hepatoma1CTD_human
HgeneCCND1C0151468Thyroid Gland Follicular Adenoma1CTD_human
HgeneCCND1C0151744Myocardial Ischemia1CTD_human
HgeneCCND1C0153437Malignant neoplasm of cecum1CTD_human
HgeneCCND1C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneCCND1C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneCCND1C0205643Carcinoma, Cribriform1CTD_human
HgeneCCND1C0205644Carcinoma, Granular Cell1CTD_human
HgeneCCND1C0205645Adenocarcinoma, Tubular1CTD_human
HgeneCCND1C0205874Papilloma, Squamous Cell1CTD_human
HgeneCCND1C0205875Papillomatosis1CTD_human
HgeneCCND1C0220636Malignant neoplasm of salivary gland1CTD_human
HgeneCCND1C0235874Disease Exacerbation1CTD_human
HgeneCCND1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneCCND1C0282313Condition, Preneoplastic1CTD_human
HgeneCCND1C0345904Malignant neoplasm of liver1CTD_human
HgeneCCND1C0376358Malignant neoplasm of prostate1CTD_human
HgeneCCND1C0476089Endometrial Carcinoma1CTD_human
HgeneCCND1C0546837Malignant neoplasm of esophagus1CTD_human
HgeneCCND1C0549473Thyroid carcinoma1CTD_human
HgeneCCND1C0740457Malignant neoplasm of kidney1CTD_human
HgeneCCND1C0751571Cancer of Urinary Tract1CTD_human
HgeneCCND1C0919532Genomic Instability1CTD_human
HgeneCCND1C1269683Major Depressive Disorder1PSYGENET
HgeneCCND1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneCCND1C2931822Nasopharyngeal carcinoma1CTD_human
HgeneCCND1C4048328cervical cancer1CTD_human
TgeneC0339273Corneal dystrophy, Lattice type 32CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0014175Endometriosis1CTD_human
TgeneC0269102Endometrioma1CTD_human