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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:BCL3-PPP5C (FusionGDB2 ID:HG602TG5536) |
Fusion Gene Summary for BCL3-PPP5C |
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Fusion gene information | Fusion gene name: BCL3-PPP5C | Fusion gene ID: hg602tg5536 | Hgene | Tgene | Gene symbol | BCL3 | PPP5C | Gene ID | 602 | 5536 |
Gene name | BCL3 transcription coactivator | protein phosphatase 5 catalytic subunit | |
Synonyms | BCL4|D19S37 | PP5|PPP5|PPT | |
Cytomap | ('BCL3')('PPP5C') 19q13.32 | 19q13.32 | |
Type of gene | protein-coding | protein-coding | |
Description | B-cell lymphoma 3 proteinB cell CLL/lymphoma 3B-cell leukemia/lymphoma 3B-cell lymphoma 3-encoded proteinBCL-3chronic lymphatic leukemia proteinproto-oncogene BCL3 | serine/threonine-protein phosphatase 5PP-Tprotein phosphatase T | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000164227, ENST00000487394, | ||
Fusion gene scores | * DoF score | 8 X 9 X 6=432 | 8 X 7 X 6=336 |
# samples | 9 | 8 | |
** MAII score | log2(9/432*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BCL3 [Title/Abstract] AND PPP5C [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | BCL3(45254637)-PPP5C(46878861), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | BCL3-PPP5C seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. BCL3-PPP5C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BCL3 | GO:0006351 | transcription, DNA-templated | 16306601 |
Hgene | BCL3 | GO:0006974 | cellular response to DNA damage stimulus | 16384933 |
Hgene | BCL3 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 8196632 |
Hgene | BCL3 | GO:0009615 | response to virus | 16306601 |
Hgene | BCL3 | GO:0010225 | response to UV-C | 16384933 |
Hgene | BCL3 | GO:0042981 | regulation of apoptotic process | 16732314 |
Hgene | BCL3 | GO:0043066 | negative regulation of apoptotic process | 16384933 |
Hgene | BCL3 | GO:0045892 | negative regulation of transcription, DNA-templated | 16306601 |
Hgene | BCL3 | GO:0045893 | positive regulation of transcription, DNA-templated | 16384933 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-JV-A5VF-01A | BCL3 | chr19 | 45254637 | + | PPP5C | chr19 | 46878861 | + |
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Fusion Gene ORF analysis for BCL3-PPP5C |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000164227 | ENST00000012443 | BCL3 | chr19 | 45254637 | + | PPP5C | chr19 | 46878861 | + |
Frame-shift | ENST00000164227 | ENST00000391919 | BCL3 | chr19 | 45254637 | + | PPP5C | chr19 | 46878861 | + |
intron-3CDS | ENST00000487394 | ENST00000012443 | BCL3 | chr19 | 45254637 | + | PPP5C | chr19 | 46878861 | + |
intron-3CDS | ENST00000487394 | ENST00000391919 | BCL3 | chr19 | 45254637 | + | PPP5C | chr19 | 46878861 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for BCL3-PPP5C |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
BCL3 | chr19 | 45254637 | + | PPP5C | chr19 | 46878860 | + | 4.21E-10 | 1 |
BCL3 | chr19 | 45254637 | + | PPP5C | chr19 | 46878860 | + | 4.21E-10 | 1 |
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Fusion Protein Features for BCL3-PPP5C |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45254637/:46878861) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for BCL3-PPP5C |
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Fusion Gene PPI Analysis for BCL3-PPP5C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BCL3-PPP5C |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BCL3-PPP5C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BCL3 | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | BCL3 | C0242339 | Dyslipidemias | 1 | CTD_human |
Hgene | BCL3 | C0598784 | Dyslipoproteinemias | 1 | CTD_human |
Hgene | BCL3 | C1563937 | Atherogenesis | 1 | CTD_human |