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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C12orf10-NFX1 (FusionGDB2 ID:HG60314TG4799)

Fusion Gene Summary for C12orf10-NFX1

check button Fusion gene summary
Fusion gene informationFusion gene name: C12orf10-NFX1
Fusion gene ID: hg60314tg4799
HgeneTgene
Gene symbol

C12orf10

NFX1

Gene ID

60314

4799

Gene nameMYG1 exonucleasenuclear transcription factor, X-box binding 1
SynonymsC12orf10|Gamm1|MST024|MSTP024|MYGNFX2|TEG-42|Tex42
Cytomap('C12orf10')('NFX1')

12q13.13

9p13.3

Type of geneprotein-codingprotein-coding
DescriptionUPF0160 protein MYG1, mitochondrialmelanocyte proliferating gene 1melanocyte relatedtranscriptional repressor NF-X1nuclear transcription factor, X box-binding protein 1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000267103, ENST00000548632, 
ENST00000549488, 
Fusion gene scores* DoF score6 X 8 X 3=14414 X 12 X 9=1512
# samples 815
** MAII scorelog2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1512*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C12orf10 [Title/Abstract] AND NFX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC12orf10(53700104)-NFX1(33366626), # samples:2
Anticipated loss of major functional domain due to fusion event.C12orf10-NFX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf10-NFX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf10-NFX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf10-NFX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFX1

GO:0000122

negative regulation of transcription by RNA polymerase II

7964459

TgeneNFX1

GO:0051865

protein autoubiquitination

10500182


check buttonFusion gene breakpoints across C12orf10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NFX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-6956C12orf10chr12

53700104

+NFX1chr9

33366626

+


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Fusion Gene ORF analysis for C12orf10-NFX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000267103ENST00000463421C12orf10chr12

53700104

+NFX1chr9

33366626

+
5CDS-3UTRENST00000548632ENST00000463421C12orf10chr12

53700104

+NFX1chr9

33366626

+
5CDS-3UTRENST00000549488ENST00000463421C12orf10chr12

53700104

+NFX1chr9

33366626

+
5CDS-intronENST00000267103ENST00000318524C12orf10chr12

53700104

+NFX1chr9

33366626

+
5CDS-intronENST00000267103ENST00000379521C12orf10chr12

53700104

+NFX1chr9

33366626

+
5CDS-intronENST00000548632ENST00000318524C12orf10chr12

53700104

+NFX1chr9

33366626

+
5CDS-intronENST00000548632ENST00000379521C12orf10chr12

53700104

+NFX1chr9

33366626

+
5CDS-intronENST00000549488ENST00000318524C12orf10chr12

53700104

+NFX1chr9

33366626

+
5CDS-intronENST00000549488ENST00000379521C12orf10chr12

53700104

+NFX1chr9

33366626

+
In-frameENST00000267103ENST00000379540C12orf10chr12

53700104

+NFX1chr9

33366626

+
In-frameENST00000548632ENST00000379540C12orf10chr12

53700104

+NFX1chr9

33366626

+
In-frameENST00000549488ENST00000379540C12orf10chr12

53700104

+NFX1chr9

33366626

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000267103C12orf10chr1253700104+ENST00000379540NFX1chr933366626+2320817281140370
ENST00000548632C12orf10chr1253700104+ENST00000379540NFX1chr933366626+21036003923306
ENST00000549488C12orf10chr1253700104+ENST00000379540NFX1chr933366626+1949446170769199

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267103ENST00000379540C12orf10chr1253700104+NFX1chr933366626+0.0031200030.99688005
ENST00000548632ENST00000379540C12orf10chr1253700104+NFX1chr933366626+0.0089392810.9910607
ENST00000549488ENST00000379540C12orf10chr1253700104+NFX1chr933366626+0.0061581090.9938419

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Fusion Genomic Features for C12orf10-NFX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C12orf10chr1253700104+NFX1chr933366626+0.036395760.9636043
C12orf10chr1253700104+NFX1chr933366626+0.036395760.9636043

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C12orf10-NFX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:53700104/chr9:33366626)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNFX1chr12:53700104chr9:33366626ENST000003185240161084_10890834.0Compositional biasNote=Poly-Pro
TgeneNFX1chr12:53700104chr9:33366626ENST000003795210211084_108901025.0Compositional biasNote=Poly-Pro
TgeneNFX1chr12:53700104chr9:33366626ENST0000037954020241084_108910131121.0Compositional biasNote=Poly-Pro
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016994_10620834.0DomainR3H
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021994_106201025.0DomainR3H
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016358_4090834.0Zinc fingerRING-type%3B atypical
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016453_4710834.0Zinc fingerNote=NF-X1-type 1
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016506_5250834.0Zinc fingerNote=NF-X1-type 2
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016567_5860834.0Zinc fingerNote=NF-X1-type 3
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016632_6550834.0Zinc fingerNote=NF-X1-type 4
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016694_7130834.0Zinc fingerNote=NF-X1-type 5
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016721_7400834.0Zinc fingerNote=NF-X1-type 6
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016832_8540834.0Zinc fingerNote=NF-X1-type 7
TgeneNFX1chr12:53700104chr9:33366626ENST00000318524016863_8840834.0Zinc fingerNote=NF-X1-type 8
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021358_40901025.0Zinc fingerRING-type%3B atypical
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021453_47101025.0Zinc fingerNote=NF-X1-type 1
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021506_52501025.0Zinc fingerNote=NF-X1-type 2
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021567_58601025.0Zinc fingerNote=NF-X1-type 3
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021632_65501025.0Zinc fingerNote=NF-X1-type 4
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021694_71301025.0Zinc fingerNote=NF-X1-type 5
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021721_74001025.0Zinc fingerNote=NF-X1-type 6
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021832_85401025.0Zinc fingerNote=NF-X1-type 7
TgeneNFX1chr12:53700104chr9:33366626ENST00000379521021863_88401025.0Zinc fingerNote=NF-X1-type 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024994_106210131121.0DomainR3H
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024358_40910131121.0Zinc fingerRING-type%3B atypical
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024453_47110131121.0Zinc fingerNote=NF-X1-type 1
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024506_52510131121.0Zinc fingerNote=NF-X1-type 2
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024567_58610131121.0Zinc fingerNote=NF-X1-type 3
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024632_65510131121.0Zinc fingerNote=NF-X1-type 4
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024694_71310131121.0Zinc fingerNote=NF-X1-type 5
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024721_74010131121.0Zinc fingerNote=NF-X1-type 6
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024832_85410131121.0Zinc fingerNote=NF-X1-type 7
TgeneNFX1chr12:53700104chr9:33366626ENST000003795402024863_88410131121.0Zinc fingerNote=NF-X1-type 8


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Fusion Gene Sequence for C12orf10-NFX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10796_10796_1_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000267103_NFX1_chr9_33366626_ENST00000379540_length(transcript)=2320nt_BP=817nt
TGGCGCTTCCTCTTCCGGGTCGGCGCTCCTGCCTCCCTGCAGGGAGCTGCTTATGGGACACCAATTCCTGCGCGGCCTCTTAACGCTGCT
GCTGCCGCCGCCACCCCTGTATACCCGGCACCGCATGCTCGGTCCAGAGTCCGTCCCGCCCCCAAAACGATCCCGCAGCAAACTCATGGC
ACCGCCCCGAATCGGGACGCACAATGGCACCTTCCACTGCGACGAGGCACTGGCATGCGCACTGCTTCGCCTCCTGCCGGAGTACCGGGA
TGCAGAGATTGTGCGGACCCGGGATCCCGAAAAACTCGCTTCCTGTGACATCGTGGTGGACGTGGGGGGCGAGTACGACCCTCGGAGACA
CCGATATGACCATCACCAGAGGTCTTTCACAGAGACCATGAGCTCCCTGTCCCCTGGGAAGCCGTGGCAGACCAAGCTGAGCAGTGCGGG
ACTCATCTATCTGCACTTCGGGCACAAGCTGCTGGCCCAGTTGCTGGGCACTAGTGAAGAGGACAGCATGGTGGGCACCCTCTATGACAA
GATGTATGAGAACTTTGTGGAGGAGGTGGATGCTGTGGACAATGGGATCTCCCAGTGGGCAGAGGGGGAGCCTCGATATGCACTGACCAC
TACCCTGAGTGCACGAGTTGCTCGACTTAATCCTACCTGGAACCACCCCGACCAAGACACTGAGGCAGGGTTCAAGCGTGCAATGGATCT
GGTTCAAGAGGAGTTTCTGCAGAGATTAGATTTCTACCAACACAGCTGGCTGCCAGCCCGGGCCTTGGTGGAAGAGGCCCTTGCCCAGCG
ATTCCAGGGAAAGAATAGTAAGAAAAGCCACAGCTTCCCTCCCATGAACAGAGACCACCGCCGGATCATCCATGACTTGGCCCAAGTTTA
TGGCCTGGAGAGCGTGAGCTATGACAGTGAACCGAAGCGCAATGTGGTGGTCACTGCCATCAGGGGGAAGTCCGTTTGTCCTCCTACCAC
GCTGACAGGTGTGCTTGAAAGGGAAATGCAGGCACGGCCTCCACCACCGATTCCTCATCACAGACATCAGTCAGACAAGAATCCTGGGAG
CAGTAATTTACAGAAAATAACCAAGGAGCCAATAATTGACTATTTTGACGTCCAGGACTAAGAAGATCATGATGCACTTAGATAAAAGAA
TGATTAGGTATAGTGGAGACTTATTTGCCAGCAGATAAATCATGCCCGTTCCCCTCTGCCTGGCAGAATCACAGTCTCACATACTGTCTT
GTACTGACACATCCAAAGCATGAGTGTGTCAGAAATCCCTTGTCTATTCCTGTCTGTATAAAGTGTTTCATTATGACCAGATCTCTGATT
GTATGGTCACTAGGTATGCAATCACGCATTCAAAGAGGCTCTTTACACCATCACTGTGATTGCTCTGAGAGTTGAGGGACTATTGGGCTT
TATTTGGACAAACCAAACTTTTAGCCTGAAACCAACTTTATGCCACTAAGTCATAGCCTCAGTTGTCCCAGTTATTTGTCCTCCTGAAAA
TGCCTGAAACATCAGACAGACATTGCTTGCTTTACCCAAACTGATCAAAATCTTTAGGAGCACAAATGAATTTTTTAGTCTGAAATACCA
AATAATGAATTGGTATACCATATCCGGAATCACACATGTTATCTTAAACCCAGCCATCATACCTAAGTCTTTTGCCAAAACCTCTCATAG
GTATATCTAGCTGAACTTATTTTGGCATTTTCAATGTGATCAGTTCTAGACCTAGAAGGGGGTCAGGCTGCTTTACAGAATTCTATTTCC
TTAAGTCCCTGGCACTTCTCATACCACATCACTGAACCTGTTCAGTAACAATCAGTTTGGCCGTCCCCCATGATGGTAGGAAATATAGAG
AGCAAGTTCTTCTGCCAGGGTCACACTGTGGTCTCTGAACTGACCAGTATATCCCTAACTCCTCTTTGATAGAGAAAGAGTCTCAAATGG
ACAACTGTCCTGTGTTGCTTTCCCTAGGCCTTCAGCAGCCTATTGGCTCTCCCTGCCTCTGAGCTCTGGACTCTGTTTGAATATTCCAAG
TAGTATATGGACAGTCCAGGGCTTATGCCCAGCAGCCCACTGGAGGCATTCTTCAGGCTCCTTTAAGGCAGGTGCATTGATAGTTCCATT
AGTGTGACCCTTGCATTGGCACCCCTCCAGCCTGGAGGCCAGGCTTCCAGCAACTTCCTTCTGCCCTAGAGCAAGCCATGAGCCCCAGAG

>10796_10796_1_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000267103_NFX1_chr9_33366626_ENST00000379540_length(amino acids)=370AA_BP=262
MPPCRELLMGHQFLRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDP
EKLASCDIVVDVGGEYDPRRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKMYENFVEEV
DAVDNGISQWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQRFQGKNSKKS
HSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARPPPPIPHHRHQSDKNPGSSNLQKITKE

--------------------------------------------------------------
>10796_10796_2_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000548632_NFX1_chr9_33366626_ENST00000379540_length(transcript)=2103nt_BP=600nt
TTCCTGCGCGGCCTCTTAACGCTGCTGCTGCCGCCGCCACCCCTGTATACCCGGCACCGCATGCTCGGTCCAGAGTCCGTCCCGCCCCCA
AAACGATCCCGCAGCAAACTCATGGCACCGCCCCGAATCGGGACGCACAATGGCACCTTCCACTGCGACGAGGCACTGGCATGCGCACTG
CTTCGCCTCCTGCCGGAGTACCGGGATGCAGAGATTGTGCGGACCCGGGATCCCGAAAAACTCGCTTCCTGTGACATCGTGGTGGACGTG
GGGGGCGAGTACGACCCTCGGAGACACCGATATGACCATCACCAGAGGTCTTTCACAGAGACCATGAGCTCCCTGTCCCCTGGGAAGCCG
TGGCAGACCAAGCTGAGCAGTGCGGGACTCATCTATCTGCACTTCGGGCACAAGCTGCTGGCCCAGTTGCTGGGCACTAGTGAAGAGGAC
AGCATGGTGGGCACCCTCTATGACAAGGCAGGGTTCAAGCGTGCAATGGATCTGGTTCAAGAGGAGTTTCTGCAGAGATTAGATTTCTAC
CAACACAGCTGGCTGCCAGCCCGGGCCTTGGTGGAAGAGGCCCTTGCCCAGCGATTCCAGGGAAAGAATAGTAAGAAAAGCCACAGCTTC
CCTCCCATGAACAGAGACCACCGCCGGATCATCCATGACTTGGCCCAAGTTTATGGCCTGGAGAGCGTGAGCTATGACAGTGAACCGAAG
CGCAATGTGGTGGTCACTGCCATCAGGGGGAAGTCCGTTTGTCCTCCTACCACGCTGACAGGTGTGCTTGAAAGGGAAATGCAGGCACGG
CCTCCACCACCGATTCCTCATCACAGACATCAGTCAGACAAGAATCCTGGGAGCAGTAATTTACAGAAAATAACCAAGGAGCCAATAATT
GACTATTTTGACGTCCAGGACTAAGAAGATCATGATGCACTTAGATAAAAGAATGATTAGGTATAGTGGAGACTTATTTGCCAGCAGATA
AATCATGCCCGTTCCCCTCTGCCTGGCAGAATCACAGTCTCACATACTGTCTTGTACTGACACATCCAAAGCATGAGTGTGTCAGAAATC
CCTTGTCTATTCCTGTCTGTATAAAGTGTTTCATTATGACCAGATCTCTGATTGTATGGTCACTAGGTATGCAATCACGCATTCAAAGAG
GCTCTTTACACCATCACTGTGATTGCTCTGAGAGTTGAGGGACTATTGGGCTTTATTTGGACAAACCAAACTTTTAGCCTGAAACCAACT
TTATGCCACTAAGTCATAGCCTCAGTTGTCCCAGTTATTTGTCCTCCTGAAAATGCCTGAAACATCAGACAGACATTGCTTGCTTTACCC
AAACTGATCAAAATCTTTAGGAGCACAAATGAATTTTTTAGTCTGAAATACCAAATAATGAATTGGTATACCATATCCGGAATCACACAT
GTTATCTTAAACCCAGCCATCATACCTAAGTCTTTTGCCAAAACCTCTCATAGGTATATCTAGCTGAACTTATTTTGGCATTTTCAATGT
GATCAGTTCTAGACCTAGAAGGGGGTCAGGCTGCTTTACAGAATTCTATTTCCTTAAGTCCCTGGCACTTCTCATACCACATCACTGAAC
CTGTTCAGTAACAATCAGTTTGGCCGTCCCCCATGATGGTAGGAAATATAGAGAGCAAGTTCTTCTGCCAGGGTCACACTGTGGTCTCTG
AACTGACCAGTATATCCCTAACTCCTCTTTGATAGAGAAAGAGTCTCAAATGGACAACTGTCCTGTGTTGCTTTCCCTAGGCCTTCAGCA
GCCTATTGGCTCTCCCTGCCTCTGAGCTCTGGACTCTGTTTGAATATTCCAAGTAGTATATGGACAGTCCAGGGCTTATGCCCAGCAGCC
CACTGGAGGCATTCTTCAGGCTCCTTTAAGGCAGGTGCATTGATAGTTCCATTAGTGTGACCCTTGCATTGGCACCCCTCCAGCCTGGAG
GCCAGGCTTCCAGCAACTTCCTTCTGCCCTAGAGCAAGCCATGAGCCCCAGAGCAGTAGCAGGAGACTTGAGAAGTAGAGTGACAAAAAC

>10796_10796_2_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000548632_NFX1_chr9_33366626_ENST00000379540_length(amino acids)=306AA_BP=198
MRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDPEKLASCDIVVDVG
GEYDPRRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKAGFKRAMDLVQEEFLQRLDFYQ
HSWLPARALVEEALAQRFQGKNSKKSHSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARP

--------------------------------------------------------------
>10796_10796_3_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000549488_NFX1_chr9_33366626_ENST00000379540_length(transcript)=1949nt_BP=446nt
CATTAATCCCCTACCCGGCGACACCCGGCAGCCCCTTCACCCCTGTGTACCTCGCAGGATGCAGAGATTGTGCGGACCCGGGATCCCGAA
AAACTCGCTTCCTGTGACATCGTGGTGGACGTGGGGGGCGAGTACGACCCTCGGAGACACCGATATGACCATCACCAGAGATGTATGAGA
ACTTTGTGGAGGAGGTGGATGCTGTGGACAATGGGATCTCCCAGTGGGCAGAGGGGGAGCCTCGATATGCACTGACCACTACCCTGAGTG
CACGAGTTGCTCGACTTAATCCTACCTGGAACCACCCCGACCAAGACACTGAGGCAGGGTTCAAGCGTGCAATGGATCTGGTTCAAGAGG
AGTTTCTGCAGAGATTAGATTTCTACCAACACAGCTGGCTGCCAGCCCGGGCCTTGGTGGAAGAGGCCCTTGCCCAGCGATTCCAGGGAA
AGAATAGTAAGAAAAGCCACAGCTTCCCTCCCATGAACAGAGACCACCGCCGGATCATCCATGACTTGGCCCAAGTTTATGGCCTGGAGA
GCGTGAGCTATGACAGTGAACCGAAGCGCAATGTGGTGGTCACTGCCATCAGGGGGAAGTCCGTTTGTCCTCCTACCACGCTGACAGGTG
TGCTTGAAAGGGAAATGCAGGCACGGCCTCCACCACCGATTCCTCATCACAGACATCAGTCAGACAAGAATCCTGGGAGCAGTAATTTAC
AGAAAATAACCAAGGAGCCAATAATTGACTATTTTGACGTCCAGGACTAAGAAGATCATGATGCACTTAGATAAAAGAATGATTAGGTAT
AGTGGAGACTTATTTGCCAGCAGATAAATCATGCCCGTTCCCCTCTGCCTGGCAGAATCACAGTCTCACATACTGTCTTGTACTGACACA
TCCAAAGCATGAGTGTGTCAGAAATCCCTTGTCTATTCCTGTCTGTATAAAGTGTTTCATTATGACCAGATCTCTGATTGTATGGTCACT
AGGTATGCAATCACGCATTCAAAGAGGCTCTTTACACCATCACTGTGATTGCTCTGAGAGTTGAGGGACTATTGGGCTTTATTTGGACAA
ACCAAACTTTTAGCCTGAAACCAACTTTATGCCACTAAGTCATAGCCTCAGTTGTCCCAGTTATTTGTCCTCCTGAAAATGCCTGAAACA
TCAGACAGACATTGCTTGCTTTACCCAAACTGATCAAAATCTTTAGGAGCACAAATGAATTTTTTAGTCTGAAATACCAAATAATGAATT
GGTATACCATATCCGGAATCACACATGTTATCTTAAACCCAGCCATCATACCTAAGTCTTTTGCCAAAACCTCTCATAGGTATATCTAGC
TGAACTTATTTTGGCATTTTCAATGTGATCAGTTCTAGACCTAGAAGGGGGTCAGGCTGCTTTACAGAATTCTATTTCCTTAAGTCCCTG
GCACTTCTCATACCACATCACTGAACCTGTTCAGTAACAATCAGTTTGGCCGTCCCCCATGATGGTAGGAAATATAGAGAGCAAGTTCTT
CTGCCAGGGTCACACTGTGGTCTCTGAACTGACCAGTATATCCCTAACTCCTCTTTGATAGAGAAAGAGTCTCAAATGGACAACTGTCCT
GTGTTGCTTTCCCTAGGCCTTCAGCAGCCTATTGGCTCTCCCTGCCTCTGAGCTCTGGACTCTGTTTGAATATTCCAAGTAGTATATGGA
CAGTCCAGGGCTTATGCCCAGCAGCCCACTGGAGGCATTCTTCAGGCTCCTTTAAGGCAGGTGCATTGATAGTTCCATTAGTGTGACCCT
TGCATTGGCACCCCTCCAGCCTGGAGGCCAGGCTTCCAGCAACTTCCTTCTGCCCTAGAGCAAGCCATGAGCCCCAGAGCAGTAGCAGGA

>10796_10796_3_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000549488_NFX1_chr9_33366626_ENST00000379540_length(amino acids)=199AA_BP=91
MYENFVEEVDAVDNGISQWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQR
FQGKNSKKSHSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARPPPPIPHHRHQSDKNPGS

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Fusion Gene PPI Analysis for C12orf10-NFX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNFX1chr12:53700104chr9:33366626ENST000003185240169_260834.0PABPC1 and PABC4
TgeneNFX1chr12:53700104chr9:33366626ENST000003795210219_2601025.0PABPC1 and PABC4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNFX1chr12:53700104chr9:33366626ENST0000037954020249_261013.01121.0PABPC1 and PABC4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C12orf10-NFX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C12orf10-NFX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource