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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:C12orf10-NFX1 (FusionGDB2 ID:HG60314TG4799)

Fusion Gene Summary for C12orf10-NFX1

Fusion gene summary

Fusion gene information	Fusion gene name: C12orf10-NFX1
	Fusion gene ID: hg60314tg4799
		Hgene	Tgene
	Gene symbol	C12orf10	NFX1
	Gene ID	60314	4799
	Gene name	MYG1 exonuclease	nuclear transcription factor, X-box binding 1
	Synonyms	C12orf10\|Gamm1\|MST024\|MSTP024\|MYG	NFX2\|TEG-42\|Tex42
	Cytomap	('C12orf10')('NFX1') 12q13.13	9p13.3
	Type of gene	protein-coding	protein-coding
	Description	UPF0160 protein MYG1, mitochondrialmelanocyte proliferating gene 1melanocyte related	transcriptional repressor NF-X1nuclear transcription factor, X box-binding protein 1
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000267103, ENST00000548632, ENST00000549488,
Fusion gene scores	* DoF score	6 X 8 X 3=144	14 X 12 X 9=1512
	# samples	8	15
	** MAII score	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1512*10)=-3.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: C12orf10 [Title/Abstract] AND NFX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C12orf10(53700104)-NFX1(33366626), # samples:2
Anticipated loss of major functional domain due to fusion event.	C12orf10-NFX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C12orf10-NFX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C12orf10-NFX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. C12orf10-NFX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NFX1	GO:0000122	negative regulation of transcription by RNA polymerase II	7964459
Tgene	NFX1	GO:0051865	protein autoubiquitination	10500182

Fusion gene breakpoints across C12orf10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NFX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-6956	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+

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Fusion Gene ORF analysis for C12orf10-NFX1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000267103	ENST00000463421	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
5CDS-3UTR	ENST00000548632	ENST00000463421	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
5CDS-3UTR	ENST00000549488	ENST00000463421	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
5CDS-intron	ENST00000267103	ENST00000318524	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
5CDS-intron	ENST00000267103	ENST00000379521	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
5CDS-intron	ENST00000548632	ENST00000318524	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
5CDS-intron	ENST00000548632	ENST00000379521	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
5CDS-intron	ENST00000549488	ENST00000318524	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
5CDS-intron	ENST00000549488	ENST00000379521	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
In-frame	ENST00000267103	ENST00000379540	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
In-frame	ENST00000548632	ENST00000379540	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+
In-frame	ENST00000549488	ENST00000379540	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000267103

C12orf10

chr12

53700104

ENST00000379540

NFX1

chr9

33366626

2320

817

1140

370

ENST00000548632

C12orf10

chr12

53700104

ENST00000379540

NFX1

chr9

33366626

2103

600

923

306

ENST00000549488

C12orf10

chr12

53700104

ENST00000379540

NFX1

chr9

33366626

1949

446

170

769

199

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000267103	ENST00000379540	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+	0.003120003	0.99688005
ENST00000548632	ENST00000379540	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+	0.008939281	0.9910607
ENST00000549488	ENST00000379540	C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+	0.006158109	0.9938419

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Fusion Genomic Features for C12orf10-NFX1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+	0.03639576	0.9636043
C12orf10	chr12	53700104	+	NFX1	chr9	33366626	+	0.03639576	0.9636043

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C12orf10-NFX1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:53700104/chr9:33366626)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

1084_1089

834.0

Compositional bias

Note=Poly-Pro

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

1084_1089

1025.0

Compositional bias

Note=Poly-Pro

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

1084_1089

1013

1121.0

Compositional bias

Note=Poly-Pro

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

994_1062

834.0

Domain

R3H

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

994_1062

1025.0

Domain

R3H

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

358_409

834.0

Zinc finger

RING-type%3B atypical

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

453_471

834.0

Zinc finger

Note=NF-X1-type 1

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

506_525

834.0

Zinc finger

Note=NF-X1-type 2

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

567_586

834.0

Zinc finger

Note=NF-X1-type 3

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

632_655

834.0

Zinc finger

Note=NF-X1-type 4

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

694_713

834.0

Zinc finger

Note=NF-X1-type 5

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

721_740

834.0

Zinc finger

Note=NF-X1-type 6

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

832_854

834.0

Zinc finger

Note=NF-X1-type 7

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000318524

863_884

834.0

Zinc finger

Note=NF-X1-type 8

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

358_409

1025.0

Zinc finger

RING-type%3B atypical

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

453_471

1025.0

Zinc finger

Note=NF-X1-type 1

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

506_525

1025.0

Zinc finger

Note=NF-X1-type 2

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

567_586

1025.0

Zinc finger

Note=NF-X1-type 3

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

632_655

1025.0

Zinc finger

Note=NF-X1-type 4

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

694_713

1025.0

Zinc finger

Note=NF-X1-type 5

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

721_740

1025.0

Zinc finger

Note=NF-X1-type 6

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

832_854

1025.0

Zinc finger

Note=NF-X1-type 7

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379521

863_884

1025.0

Zinc finger

Note=NF-X1-type 8

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

994_1062

1013

1121.0

Domain

R3H

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

358_409

1013

1121.0

Zinc finger

RING-type%3B atypical

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

453_471

1013

1121.0

Zinc finger

Note=NF-X1-type 1

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

506_525

1013

1121.0

Zinc finger

Note=NF-X1-type 2

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

567_586

1013

1121.0

Zinc finger

Note=NF-X1-type 3

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

632_655

1013

1121.0

Zinc finger

Note=NF-X1-type 4

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

694_713

1013

1121.0

Zinc finger

Note=NF-X1-type 5

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

721_740

1013

1121.0

Zinc finger

Note=NF-X1-type 6

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

832_854

1013

1121.0

Zinc finger

Note=NF-X1-type 7

Tgene

NFX1

chr12:53700104

chr9:33366626

ENST00000379540

863_884

1013

1121.0

Zinc finger

Note=NF-X1-type 8

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Fusion Gene Sequence for C12orf10-NFX1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>10796_10796_1_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000267103_NFX1_chr9_33366626_ENST00000379540_length(transcript)=2320nt_BP=817nt
TGGCGCTTCCTCTTCCGGGTCGGCGCTCCTGCCTCCCTGCAGGGAGCTGCTTATGGGACACCAATTCCTGCGCGGCCTCTTAACGCTGCT
GCTGCCGCCGCCACCCCTGTATACCCGGCACCGCATGCTCGGTCCAGAGTCCGTCCCGCCCCCAAAACGATCCCGCAGCAAACTCATGGC
ACCGCCCCGAATCGGGACGCACAATGGCACCTTCCACTGCGACGAGGCACTGGCATGCGCACTGCTTCGCCTCCTGCCGGAGTACCGGGA
TGCAGAGATTGTGCGGACCCGGGATCCCGAAAAACTCGCTTCCTGTGACATCGTGGTGGACGTGGGGGGCGAGTACGACCCTCGGAGACA
CCGATATGACCATCACCAGAGGTCTTTCACAGAGACCATGAGCTCCCTGTCCCCTGGGAAGCCGTGGCAGACCAAGCTGAGCAGTGCGGG
ACTCATCTATCTGCACTTCGGGCACAAGCTGCTGGCCCAGTTGCTGGGCACTAGTGAAGAGGACAGCATGGTGGGCACCCTCTATGACAA
GATGTATGAGAACTTTGTGGAGGAGGTGGATGCTGTGGACAATGGGATCTCCCAGTGGGCAGAGGGGGAGCCTCGATATGCACTGACCAC
TACCCTGAGTGCACGAGTTGCTCGACTTAATCCTACCTGGAACCACCCCGACCAAGACACTGAGGCAGGGTTCAAGCGTGCAATGGATCT
GGTTCAAGAGGAGTTTCTGCAGAGATTAGATTTCTACCAACACAGCTGGCTGCCAGCCCGGGCCTTGGTGGAAGAGGCCCTTGCCCAGCG
ATTCCAGGGAAAGAATAGTAAGAAAAGCCACAGCTTCCCTCCCATGAACAGAGACCACCGCCGGATCATCCATGACTTGGCCCAAGTTTA
TGGCCTGGAGAGCGTGAGCTATGACAGTGAACCGAAGCGCAATGTGGTGGTCACTGCCATCAGGGGGAAGTCCGTTTGTCCTCCTACCAC
GCTGACAGGTGTGCTTGAAAGGGAAATGCAGGCACGGCCTCCACCACCGATTCCTCATCACAGACATCAGTCAGACAAGAATCCTGGGAG
CAGTAATTTACAGAAAATAACCAAGGAGCCAATAATTGACTATTTTGACGTCCAGGACTAAGAAGATCATGATGCACTTAGATAAAAGAA
TGATTAGGTATAGTGGAGACTTATTTGCCAGCAGATAAATCATGCCCGTTCCCCTCTGCCTGGCAGAATCACAGTCTCACATACTGTCTT
GTACTGACACATCCAAAGCATGAGTGTGTCAGAAATCCCTTGTCTATTCCTGTCTGTATAAAGTGTTTCATTATGACCAGATCTCTGATT
GTATGGTCACTAGGTATGCAATCACGCATTCAAAGAGGCTCTTTACACCATCACTGTGATTGCTCTGAGAGTTGAGGGACTATTGGGCTT
TATTTGGACAAACCAAACTTTTAGCCTGAAACCAACTTTATGCCACTAAGTCATAGCCTCAGTTGTCCCAGTTATTTGTCCTCCTGAAAA
TGCCTGAAACATCAGACAGACATTGCTTGCTTTACCCAAACTGATCAAAATCTTTAGGAGCACAAATGAATTTTTTAGTCTGAAATACCA
AATAATGAATTGGTATACCATATCCGGAATCACACATGTTATCTTAAACCCAGCCATCATACCTAAGTCTTTTGCCAAAACCTCTCATAG
GTATATCTAGCTGAACTTATTTTGGCATTTTCAATGTGATCAGTTCTAGACCTAGAAGGGGGTCAGGCTGCTTTACAGAATTCTATTTCC
TTAAGTCCCTGGCACTTCTCATACCACATCACTGAACCTGTTCAGTAACAATCAGTTTGGCCGTCCCCCATGATGGTAGGAAATATAGAG
AGCAAGTTCTTCTGCCAGGGTCACACTGTGGTCTCTGAACTGACCAGTATATCCCTAACTCCTCTTTGATAGAGAAAGAGTCTCAAATGG
ACAACTGTCCTGTGTTGCTTTCCCTAGGCCTTCAGCAGCCTATTGGCTCTCCCTGCCTCTGAGCTCTGGACTCTGTTTGAATATTCCAAG
TAGTATATGGACAGTCCAGGGCTTATGCCCAGCAGCCCACTGGAGGCATTCTTCAGGCTCCTTTAAGGCAGGTGCATTGATAGTTCCATT
AGTGTGACCCTTGCATTGGCACCCCTCCAGCCTGGAGGCCAGGCTTCCAGCAACTTCCTTCTGCCCTAGAGCAAGCCATGAGCCCCAGAG
CAGTAGCAGGAGACTTGAGAAGTAGAGTGACAAAAACAAGCACTTAATTAAATTATAAAATTTAACTTTA

>10796_10796_1_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000267103_NFX1_chr9_33366626_ENST00000379540_length(amino acids)=370AA_BP=262
MPPCRELLMGHQFLRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDP
EKLASCDIVVDVGGEYDPRRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKMYENFVEEV
DAVDNGISQWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQRFQGKNSKKS
HSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARPPPPIPHHRHQSDKNPGSSNLQKITKE
PIIDYFDVQD

--------------------------------------------------------------
>10796_10796_2_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000548632_NFX1_chr9_33366626_ENST00000379540_length(transcript)=2103nt_BP=600nt
TTCCTGCGCGGCCTCTTAACGCTGCTGCTGCCGCCGCCACCCCTGTATACCCGGCACCGCATGCTCGGTCCAGAGTCCGTCCCGCCCCCA
AAACGATCCCGCAGCAAACTCATGGCACCGCCCCGAATCGGGACGCACAATGGCACCTTCCACTGCGACGAGGCACTGGCATGCGCACTG
CTTCGCCTCCTGCCGGAGTACCGGGATGCAGAGATTGTGCGGACCCGGGATCCCGAAAAACTCGCTTCCTGTGACATCGTGGTGGACGTG
GGGGGCGAGTACGACCCTCGGAGACACCGATATGACCATCACCAGAGGTCTTTCACAGAGACCATGAGCTCCCTGTCCCCTGGGAAGCCG
TGGCAGACCAAGCTGAGCAGTGCGGGACTCATCTATCTGCACTTCGGGCACAAGCTGCTGGCCCAGTTGCTGGGCACTAGTGAAGAGGAC
AGCATGGTGGGCACCCTCTATGACAAGGCAGGGTTCAAGCGTGCAATGGATCTGGTTCAAGAGGAGTTTCTGCAGAGATTAGATTTCTAC
CAACACAGCTGGCTGCCAGCCCGGGCCTTGGTGGAAGAGGCCCTTGCCCAGCGATTCCAGGGAAAGAATAGTAAGAAAAGCCACAGCTTC
CCTCCCATGAACAGAGACCACCGCCGGATCATCCATGACTTGGCCCAAGTTTATGGCCTGGAGAGCGTGAGCTATGACAGTGAACCGAAG
CGCAATGTGGTGGTCACTGCCATCAGGGGGAAGTCCGTTTGTCCTCCTACCACGCTGACAGGTGTGCTTGAAAGGGAAATGCAGGCACGG
CCTCCACCACCGATTCCTCATCACAGACATCAGTCAGACAAGAATCCTGGGAGCAGTAATTTACAGAAAATAACCAAGGAGCCAATAATT
GACTATTTTGACGTCCAGGACTAAGAAGATCATGATGCACTTAGATAAAAGAATGATTAGGTATAGTGGAGACTTATTTGCCAGCAGATA
AATCATGCCCGTTCCCCTCTGCCTGGCAGAATCACAGTCTCACATACTGTCTTGTACTGACACATCCAAAGCATGAGTGTGTCAGAAATC
CCTTGTCTATTCCTGTCTGTATAAAGTGTTTCATTATGACCAGATCTCTGATTGTATGGTCACTAGGTATGCAATCACGCATTCAAAGAG
GCTCTTTACACCATCACTGTGATTGCTCTGAGAGTTGAGGGACTATTGGGCTTTATTTGGACAAACCAAACTTTTAGCCTGAAACCAACT
TTATGCCACTAAGTCATAGCCTCAGTTGTCCCAGTTATTTGTCCTCCTGAAAATGCCTGAAACATCAGACAGACATTGCTTGCTTTACCC
AAACTGATCAAAATCTTTAGGAGCACAAATGAATTTTTTAGTCTGAAATACCAAATAATGAATTGGTATACCATATCCGGAATCACACAT
GTTATCTTAAACCCAGCCATCATACCTAAGTCTTTTGCCAAAACCTCTCATAGGTATATCTAGCTGAACTTATTTTGGCATTTTCAATGT
GATCAGTTCTAGACCTAGAAGGGGGTCAGGCTGCTTTACAGAATTCTATTTCCTTAAGTCCCTGGCACTTCTCATACCACATCACTGAAC
CTGTTCAGTAACAATCAGTTTGGCCGTCCCCCATGATGGTAGGAAATATAGAGAGCAAGTTCTTCTGCCAGGGTCACACTGTGGTCTCTG
AACTGACCAGTATATCCCTAACTCCTCTTTGATAGAGAAAGAGTCTCAAATGGACAACTGTCCTGTGTTGCTTTCCCTAGGCCTTCAGCA
GCCTATTGGCTCTCCCTGCCTCTGAGCTCTGGACTCTGTTTGAATATTCCAAGTAGTATATGGACAGTCCAGGGCTTATGCCCAGCAGCC
CACTGGAGGCATTCTTCAGGCTCCTTTAAGGCAGGTGCATTGATAGTTCCATTAGTGTGACCCTTGCATTGGCACCCCTCCAGCCTGGAG
GCCAGGCTTCCAGCAACTTCCTTCTGCCCTAGAGCAAGCCATGAGCCCCAGAGCAGTAGCAGGAGACTTGAGAAGTAGAGTGACAAAAAC
AAGCACTTAATTAAATTATAAAATTTAACTTTA

>10796_10796_2_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000548632_NFX1_chr9_33366626_ENST00000379540_length(amino acids)=306AA_BP=198
MRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDPEKLASCDIVVDVG
GEYDPRRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKAGFKRAMDLVQEEFLQRLDFYQ
HSWLPARALVEEALAQRFQGKNSKKSHSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARP
PPPIPHHRHQSDKNPGSSNLQKITKEPIIDYFDVQD

--------------------------------------------------------------
>10796_10796_3_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000549488_NFX1_chr9_33366626_ENST00000379540_length(transcript)=1949nt_BP=446nt
CATTAATCCCCTACCCGGCGACACCCGGCAGCCCCTTCACCCCTGTGTACCTCGCAGGATGCAGAGATTGTGCGGACCCGGGATCCCGAA
AAACTCGCTTCCTGTGACATCGTGGTGGACGTGGGGGGCGAGTACGACCCTCGGAGACACCGATATGACCATCACCAGAGATGTATGAGA
ACTTTGTGGAGGAGGTGGATGCTGTGGACAATGGGATCTCCCAGTGGGCAGAGGGGGAGCCTCGATATGCACTGACCACTACCCTGAGTG
CACGAGTTGCTCGACTTAATCCTACCTGGAACCACCCCGACCAAGACACTGAGGCAGGGTTCAAGCGTGCAATGGATCTGGTTCAAGAGG
AGTTTCTGCAGAGATTAGATTTCTACCAACACAGCTGGCTGCCAGCCCGGGCCTTGGTGGAAGAGGCCCTTGCCCAGCGATTCCAGGGAA
AGAATAGTAAGAAAAGCCACAGCTTCCCTCCCATGAACAGAGACCACCGCCGGATCATCCATGACTTGGCCCAAGTTTATGGCCTGGAGA
GCGTGAGCTATGACAGTGAACCGAAGCGCAATGTGGTGGTCACTGCCATCAGGGGGAAGTCCGTTTGTCCTCCTACCACGCTGACAGGTG
TGCTTGAAAGGGAAATGCAGGCACGGCCTCCACCACCGATTCCTCATCACAGACATCAGTCAGACAAGAATCCTGGGAGCAGTAATTTAC
AGAAAATAACCAAGGAGCCAATAATTGACTATTTTGACGTCCAGGACTAAGAAGATCATGATGCACTTAGATAAAAGAATGATTAGGTAT
AGTGGAGACTTATTTGCCAGCAGATAAATCATGCCCGTTCCCCTCTGCCTGGCAGAATCACAGTCTCACATACTGTCTTGTACTGACACA
TCCAAAGCATGAGTGTGTCAGAAATCCCTTGTCTATTCCTGTCTGTATAAAGTGTTTCATTATGACCAGATCTCTGATTGTATGGTCACT
AGGTATGCAATCACGCATTCAAAGAGGCTCTTTACACCATCACTGTGATTGCTCTGAGAGTTGAGGGACTATTGGGCTTTATTTGGACAA
ACCAAACTTTTAGCCTGAAACCAACTTTATGCCACTAAGTCATAGCCTCAGTTGTCCCAGTTATTTGTCCTCCTGAAAATGCCTGAAACA
TCAGACAGACATTGCTTGCTTTACCCAAACTGATCAAAATCTTTAGGAGCACAAATGAATTTTTTAGTCTGAAATACCAAATAATGAATT
GGTATACCATATCCGGAATCACACATGTTATCTTAAACCCAGCCATCATACCTAAGTCTTTTGCCAAAACCTCTCATAGGTATATCTAGC
TGAACTTATTTTGGCATTTTCAATGTGATCAGTTCTAGACCTAGAAGGGGGTCAGGCTGCTTTACAGAATTCTATTTCCTTAAGTCCCTG
GCACTTCTCATACCACATCACTGAACCTGTTCAGTAACAATCAGTTTGGCCGTCCCCCATGATGGTAGGAAATATAGAGAGCAAGTTCTT
CTGCCAGGGTCACACTGTGGTCTCTGAACTGACCAGTATATCCCTAACTCCTCTTTGATAGAGAAAGAGTCTCAAATGGACAACTGTCCT
GTGTTGCTTTCCCTAGGCCTTCAGCAGCCTATTGGCTCTCCCTGCCTCTGAGCTCTGGACTCTGTTTGAATATTCCAAGTAGTATATGGA
CAGTCCAGGGCTTATGCCCAGCAGCCCACTGGAGGCATTCTTCAGGCTCCTTTAAGGCAGGTGCATTGATAGTTCCATTAGTGTGACCCT
TGCATTGGCACCCCTCCAGCCTGGAGGCCAGGCTTCCAGCAACTTCCTTCTGCCCTAGAGCAAGCCATGAGCCCCAGAGCAGTAGCAGGA
GACTTGAGAAGTAGAGTGACAAAAACAAGCACTTAATTAAATTATAAAATTTAACTTTA

>10796_10796_3_C12orf10-NFX1_C12orf10_chr12_53700104_ENST00000549488_NFX1_chr9_33366626_ENST00000379540_length(amino acids)=199AA_BP=91
MYENFVEEVDAVDNGISQWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQR
FQGKNSKKSHSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARPPPPIPHHRHQSDKNPGS
SNLQKITKEPIIDYFDVQD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C12orf10-NFX1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	NFX1	chr12:53700104	chr9:33366626	ENST00000318524		0	16	9_26	0	834.0	PABPC1 and PABC4
Tgene	NFX1	chr12:53700104	chr9:33366626	ENST00000379521		0	21	9_26	0	1025.0	PABPC1 and PABC4

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	NFX1	chr12:53700104	chr9:33366626	ENST00000379540		20	24	9_26	1013.0	1121.0	PABPC1 and PABC4

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for C12orf10-NFX1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for C12orf10-NFX1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Fusion Gene Studies in Kim Lab

Fusion gene:C12orf10-NFX1 (FusionGDB2 ID:HG60314TG4799)

Fusion Gene Summary for C12orf10-NFX1

Fusion Gene ORF analysis for C12orf10-NFX1

Fusion Genomic Features for C12orf10-NFX1

Fusion Protein Features for C12orf10-NFX1

Fusion Gene Sequence for C12orf10-NFX1

Fusion Gene PPI Analysis for C12orf10-NFX1

Related Drugs for C12orf10-NFX1

Related Diseases for C12orf10-NFX1

Fusion Gene Studies
in Kim Lab