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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AGBL5-CHD5 (FusionGDB2 ID:HG60509TG26038)

Fusion Gene Summary for AGBL5-CHD5

check button Fusion gene summary
Fusion gene informationFusion gene name: AGBL5-CHD5
Fusion gene ID: hg60509tg26038
HgeneTgene
Gene symbol

AGBL5

CHD5

Gene ID

60509

26038

Gene nameATP/GTP binding protein like 5chromodomain helicase DNA binding protein 5
SynonymsCCP5|RP75CHD-5
Cytomap('AGBL5')('CHD5')

2p23.3

1p36.31

Type of geneprotein-codingprotein-coding
Descriptioncytosolic carboxypeptidase-like protein 5cytosolic carboxypeptidase 5chromodomain-helicase-DNA-binding protein 5ATP-dependent helicase CHD5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000323064, ENST00000360131, 
Fusion gene scores* DoF score5 X 9 X 2=902 X 2 X 2=8
# samples 92
** MAII scorelog2(9/90*10)=0log2(2/8*10)=1.32192809488736
Context

PubMed: AGBL5 [Title/Abstract] AND CHD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGBL5(27276821)-CHD5(6214829), # samples:1
Anticipated loss of major functional domain due to fusion event.AGBL5-CHD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGBL5-CHD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGBL5-CHD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGBL5-CHD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AGBL5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CHD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for AGBL5-CHD5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323064ENST00000262450AGBL5chr227276821-CHD5chr16214829-0.317864450.6821355
ENST00000360131ENST00000262450AGBL5chr227276821-CHD5chr16214829-0.318222080.68177795

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Fusion Genomic Features for AGBL5-CHD5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AGBL5-CHD5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:27276821/chr1:6214829)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHD5chr2:27276821chr1:6214829ENST0000026245004249_11603082.3333333333335Compositional biasNote=Lys-rich
TgeneCHD5chr2:27276821chr1:6214829ENST000002624500421028_119303082.3333333333335DomainHelicase C-terminal
TgeneCHD5chr2:27276821chr1:6214829ENST00000262450042497_55403082.3333333333335DomainChromo 1
TgeneCHD5chr2:27276821chr1:6214829ENST00000262450042592_65303082.3333333333335DomainChromo 2
TgeneCHD5chr2:27276821chr1:6214829ENST00000262450042712_89603082.3333333333335DomainHelicase ATP-binding
TgeneCHD5chr2:27276821chr1:6214829ENST00000262450042847_85003082.3333333333335MotifNote=DEAH box
TgeneCHD5chr2:27276821chr1:6214829ENST00000262450042725_73203082.3333333333335Nucleotide bindingATP
TgeneCHD5chr2:27276821chr1:6214829ENST00000262450042343_65303082.3333333333335RegionNote=Histone-binding
TgeneCHD5chr2:27276821chr1:6214829ENST00000262450042343_39003082.3333333333335Zinc fingerPHD-type 1
TgeneCHD5chr2:27276821chr1:6214829ENST00000262450042416_46303082.3333333333335Zinc fingerPHD-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGBL5chr2:27276821chr1:6214829ENST00000323064-111540_5440718.0Compositional biasNote=Poly-Pro
HgeneAGBL5chr2:27276821chr1:6214829ENST00000323064-111651_6540718.0Compositional biasNote=Poly-Ser
HgeneAGBL5chr2:27276821chr1:6214829ENST00000360131-115540_5440887.0Compositional biasNote=Poly-Pro
HgeneAGBL5chr2:27276821chr1:6214829ENST00000360131-115651_6540887.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for AGBL5-CHD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2856_2856_1_AGBL5-CHD5_AGBL5_chr2_27276821_ENST00000323064_CHD5_chr1_6214829_ENST00000262450_length(transcript)=9566nt_BP=655nt
CCCGGCACCGCGGCGCTCGGGTGTTTTTGGGGGCCCGGGTGGAGGGCCCGGGTGCCGGGGCCCAAGGTGCGGCCTCGCTAGCGGGAGAGG
GAGCGGGATCACCGGCCCGGAGAGAGCTCTCAGGGCCAGAGCGGGGCAGGAGGATGCTTTCCCAGCCCCACCATGGAGCTGCGCTGTGGG
GGATTGCTGTTCAGTTCTCGCTTTGATTCAGGGAATCTAGCCCACGTGGAGAAGGTGGAATCTTTGTCCAGTGATGGGGAAGGGGTAGGA
GGTGGGGCGTCAGCCCTGACCAGTGGCATTGCCTCTTCCCCTGACTATGAATTCAACGTGTGGACCCGACCAGACTGTGCTGAAACGGAA
TTTGAGAATGGGAACAGGTCATGGTTCTACTTCAGCGTCCGGGGAGGAATGCCAGGAAAACTCATCAAGATCAACATTATGAACATGAAC
AAGCAGAGCAAGCTGTATTCCCAGGGCATGGCCCCCTTTGTGCGCACACTGCCCACCCGGCCACGCTGGGAACGCATTCGAGACCGGCCC
ACCTTTGAGCCACCACCTTCTTCGCCTTCTGCTACCCCTTCTCCTACAGTGACTGCCAGGAACTGCTAAACCAGCTAGACCAGCGCTTTC
CGGAGAACCACCCTACCCATAGCAGCCACGCCTGCCGGGCCACCTGCCCGACCCACATGGGAGAGAAAAGCTGCCACCTTTTTAGGAGCC
AGCGCCACCTTGGGACAAAAAGGGAAACCTAGTAATGCCATCACATGGAGGACGAGGCCCAGCTCAGCTGGGCCAGAGCCCAGAAGTGCC
ACCTCATCATAATTCAAGTGTTCTTCCACACAGCGTTGCCCCCACAACCACGCCGGACGTGCCCCCTCGCCACCTTTTCCAGACGACTTC
TTAGAAGAGATTTCATTTATTTGTACATCTTTTGCACTTTCCTATTGAAGACTTGAACACGTTTGTCTTGATAAAAGTTGGATGACGTAT
GGAAGATTCGAACCTGCAGCACTGATGTCTCTTTACCGATGGGTTCCAGACCCAAGGTAGTCCTGGCACTGCCCTGTGGACTCAGCCCAG
CTGGGGAGGACATGGCGCCCGGTGCCCTAGGAGCCCTCAGTGTCCCCTACCTGACCTGTCTGCACCTGTGTGACAGCCCCTTCTGATTTG
GCCCCCTGCCCGCTTGGAGCCTCCCAGCACCAGACAGGGCAGGTTTGGGGAGCCGCTGTCCAGCCCTATGGTGAGACCCTGGCTGACATT
TCCCCTCCTTCCTGCCAAGGCTGGAGGCCGCCAGGTGTTTGCTCTCTCCTTGTGGGGAGGTGGATCCTCTGCCAGCAGGTGTCTGTCCCC
GGCCCAGCGCATCTTGAAGGCCCTGGACTCTGTTACCAGTGGGGGGCCTGTGGCCCCGGCTCTTCACAGCAGGCAGAAGCGTATGATCCC
AGGGAGGGTGGGCTGGGGGGGGGGCAGCACTTGCCTCGGAGCCACTGCTGCGTTGGGTTTGCCTTCTGCCAGAGGTGTGGTTAAGGGCAG
TGATAGCTGCGCCCCAGCAAGGAGGGTCATGGGCCCTGAGCTGGCCCAGGAGACCCTGGCCCTGCCCTGTGCCCTGGGATGCCTACCCTG
CCCACCTCCGGAGGTGGAACCGGGCTGCCCCTGGGGGCCTGGACTTGTCCCATTCCCCTGTCCCTGGAAAGGCCTTCCCGGGGGCTTTTT
GCCTGAGGCTGCACTCTTGGAAGGCGTGGGGAGAGTTCTGCCTGGAGGGGGACTGGACCCAGTGCCCTCTGCAGACCCCTCCCAGCCGCA
GCACCAAGGGCTTGCTGCCTTGTTTCCTGCCAGGAGCGCCCTGACATCCCAAAACCATCTTCCCACATGTGGGTTGTTGGAATCCCACCC
ACTCCCCCGGACCCTGCCCCTCCAAGTTGGGGACGGAGATGGGGAGCAGGTCAGGCCCTCCCTAGGCCTGTTTGTGTGTGATCCTTCTCC
TGGCCCCAGGTCGACCTGGAAGGCGTTTCTGAGTCTTGTACTGGGACCTTCCCAGGGAAGGTGCCTTGGGGTGCAGAATCCTGGGAATGT
TAGGAAAGGGCTGCGTGAAAAACCCAGCTGGGCCTGGGGTGGAGGTGCACACGGGCTGGGGCTCAGCTCCTTGGAGAGGGCCTGCCTGGG
ACTGAGGGGGCCAGGGCTGGGTCAGGATTCACCAGCTTGTGTTGCAGACACTGGAGCGATTGCCTGGCCCTCCCTAAGCCCTATATGCCT
CACTCATAATGAGGCTGTCTCTGAACCCCGGAGGGCGGGACCTACAAGTCCTTCCTCTTGGCGCATTCCCACACTCCAGTCTGGATCCAG
GTCTGCAAGGCCAGCCCGACCCTGACACTGCACGTGGGCGTAGTGGGGAGCACCCTGGAGTGGAGATGATTGTCAGCGGGCTCACATGTT
ATGGTTCATCCACATGCGTGTTGTGTGCTCTGCGGTGCCTCCTGGCAAAGGGTCCTGGCTCGGGTCAGAAGCTCACTCCCGTGCCCTCGT
CCCCAAACAAGCAGTGGCAAGCACTGGGGTTGGCCCTCGTTGGGAGCAGTGCCCACCTTCCTTGGCCCACAGCAGATAGGTCCCGAGCAG
CAGGACTGGAGGCCTGTGGCGGTCAGGGCAGGGGTCTGTGTCTCCACCCCAAGGGCTGATGGTCCCTCCCCTGTGCGCCTTCCTCTCAGG
CAGGCTTGCTCTGTCCCTTCCTCTCTGCTTCCCTCCCAGGCCTCGCCAGGGCTCCCTTCTCCTCTGCCTGGTTAGACTCGGGCACCCAGG
AAAGCCTGGCCAGGGCTCCTTTGGGCCTGGGCCCCCTGCACTGCCTGGTCCAGAAGGGGTGGTGCTGTCCGTGGCCAGCACCCCGGGGCC
CGGGAGGGGTGGGCTACTAGAGTCAGAGCGGGTTTGGGGCTGACCAGTTTGGGAGAGGAGAAAAGATCTGAGAATGTCCTTCTTGGTTTG
TCAGTCATCTCTGCCAAAAGTGGTGATGGTGGTGTCCGTATGTTTGGCGTCTTTGGGCTGGGTTTGGTTTTTGCTGCTGGTAGAATCAGG
GTCCTCGGGCATGAACGCGAGCCCAAAGTGCCAGTCTGCGATTGGAAATTTCCAGCCACTTTAAGCCAGTGCTGAGTAGGGCTTCTGCAG
AGCCATGTTTGAGCCAAGGTCTTGGAAGGCATTGCCCCATGGGCTCAGGTGACTCGGGGTGGAGTGAGCACGTCTGCAGGGCCCTCTCAT
ACACGCCTGAGGCAGAAGCAGCGTCCCCCGTGAAAGCCACCTTCCGAAGCTCCTGCGTTTTTTGCAAACTTGGCTTCCCCCAGGGGCAGG
CTGGACTTTCCCTGCCCCCTATGATTGAAGTCCTCCTGCTTTTGGGGGCTGCCTTCCCAGAGTCCCCCGGGTGCTCCCCTGCCGAGGTCA
GGAGCTGACCAAGCCTTGGCCCGGTGACACCTGCAGCCCTCACTCCTGTCATCCCAGGACACTTGAGGCCCAAGGAGGTGGAGTGGAGAG
TGGGCTCGGGTACATGGGAGCCAGAAGCCAGATGGACTTGGTCAAGTGTCGGTCACTTGGAGCCTCCAGTGTGCGTCAGGGTCTGTGGGC
AGGGGACAGGGCGTGGGTGGGGGCCGAGGCTGGCACGCCCCTCTGCCCTCACCGTCTTGGTGACCTGGCCTCGGCCCCTCCCCCAAGTCT
CTTCTGTGCAAGGCCCGCCTCGGCCTCGGCAGCTGGTTCCTGTCCTGTTTTCTGTGTCTGAAAGTTTACAGGTTGTGGTGCATCAGCCCA
AACTCACTGGCGTTGTGTTTTTTTTTTCTTTAATTTTCAGATTTTTTTTTTAAACAAAGTATTTTTTTAGGTGCGATAACCCAGAAAGGG
CCCGTTGGGTGTGTGTGTGTGTCCTGAACTCCTCAAGCAGCGATTGGAGCCCAAGCACCCCTGGAGAGGAAGGGAGGGTCCCCACTGGCC
CGTGGGGTCTGAGTTCAGGGGTGTGGAGGGAGCAGACTCCACCGGCCCAGGCCCAGCTAAGAGGGGGCCGACCCCTTTCCCCAGGCACAG
CCCCAGGCTGGCAAAGGGAGGGCCCTGGGCTGGGTGCAAGGCGCGCCAGGAGTCCCAGCCAGGGTGGCCCCGGCGGGGGCGGGTCCAGCT
TTGGAAGCCAGGCTCCCCTGTGAGCCGTGGCTTGTCTGGTCTTCGCCCACGGGAGGCTGGACAGAGGCTGTAGCCAACACAATCACCTTT
ACTTTGTACTCTGTGTGTATGTTTTGGTTTTCTGTGTTTTAATAAATCCTTTGGGAAAGGATATCTAGCCGTCCTCGAGACTTCCCTGTG
TTGCAGCGCTCATTTCCAGCTGAGGGCGCTTTCGGCTCCTCCCAGATGTACAGCAACAACTTTGGGCCCAACTTCCGGGGCCCTGGACCG
GGAGGGATTGTCAACTACAACCAGATGCCCCTGGGGCCCTATGTGACCGTCCTGAACCAGCTGGAGGAGCTGCTGAGCGACATGAAGGCC
GACGTGACCCGGCTGCCATCCATGCTGTCCCGCATCCCCCCGGTGGCCGCCCGGCTGCAGATGTCGGAGCGCAGCATCCTGAGCCGCCTG
ACCAACCGCGCCGGGGACCCCACCATCCAGCAGCTGCTGGAGCAGGCGTTGGTCATTGAGGAGCAGCTCCGGAGGGCCGCGTACCTGAAC
ATGACGCAGGACCCCAACCACCCCGCCATGGCCCTCAACGCCCGCCTGGCTGAAGTGGAGTGCCTCGCCGAGAGCCACCAGCACCTGTCC
AAGGAGTCCCTTGCTGGGAACAAGCCTGCCAATGCCGTCCTGCACAAGGGCACGGCTACGCCCGCTGGCAGGACATCCAGAATGACCCAC
GGTACATGATCCTCAACGAGCCCTTCAAGTCTGAGGTCCACAAGGGCAACTACCTGGAGATGAAGAACAAGTTCCTGGCCCGCAGGTTTA
AGAGTTGCACACGCTGTGGCAGAACGAGGAGCGGGCTGCTGTATCCTCTGGGAAAATCTACGACATCTGGCACCGGCGCCATGACTACTG
GCTGCTGGCGGGCATCGTGACATGACACCAAGGCTGAGGAGAAGGAGCCCATTGAAACACAGCAAAATGGTGACAAAGAGGAAGATGACG
AGGGGAAGAAGGAGGACAAGAAGGGGAAATTCAAGTTCATGTTCAACATCGCGGACGGGGGCTTCACGGAGGAGGTGCTTCCTGAGAAGG
AGAAGATCCTGGACAAGCTGGAGCTGAGCTTGATCCACAGCAGAGGGGACAGTTCCGAACTCAGGCCAGGCCCTTCCAGCCGCCTTGGAT
AGAGTGGAGAGTGAGGACAAGCACGAGAGCCCAGCCAGCAAGGAGAGAGCCCGAGAGGAGCGGCCAGAGGAGACGGAGAAGGCCCCGCCC
TCCCCGGAGCAGCTGCCGAGAGACAAAATGGAAGCCCAGCTGGGCTACATGGATGAGAAAGACCCCGGGGCACAGAAGCCAAGGCAGCCC
CTGGAAGTCCAGGTTCAGGAGTTTGAGCATGTCAACGGGAAGTACAGCACCCCAGACTTGATCCCTGAGGGGCCCGAGGGGAAGAAGTCG
GGCGAGGTGATCTCCTCGGACCCCAACACACCAGTGCCCGCCAGCCCTGCCCACCTCCTGCCAGCCCCGCTGGGCCTGCCAGAGCCTATG
TGTCCCTCTTCATGCGGCACCTGTGTGAGCCGGGGGCGGATGGTGCAGAGACCTTCGCAGACGGCGTGCCCCGGGAGGGCCTCTCCAGGC
AGCACGTGCTGACCCGCATCGGGGTCATGTCACTAGTTAGGAAGAAGGTGCTGGGCTTCAATGCCCGACAGCGGAAGGCCTTTCTGAACG
CCATCATGCGCTGGGGCATGCCCCCGCAGGACGCCTTCAACTCCCACTGGCTGGTGCGGGACCTTCGAGGGAAGAGCGAGAAGGAGTTTA
GGTGGACGACGACAATCCCGGAGGCAGCTGAAGAGTGACAGGGACAAGCCCCTGCCCCCGCTTCTCGCCCGAGTTGGTGGCAACATCGAG
AGTGGCAGGATGAGCTCTCTGATAACCAGTCAGAATATTCCATTGGCTCTGAGGATGAGGATGAGGACTTTGAAGAGAGGCCGGAAGGGC
AGAGAGGAGGTGGAGCGGGAAATCATCAAGCAGGAGGAGAACGTGGACCCCGACTACTGGGAGAAGCTGCTGCGGCACCACTATGAGCAG
CAGCAGGAGGACCTGGCCCGCAACCTGGGCAAGGGCAAGCGCATCCGCAAGCAGGTCAACTACAACGATGCCTCCCAGGAGGACCAGGGT
GACAACAAGGACGTGGAGGACAGCAGTGTGATCCACTATGACGATGCGGCCATCTCCAAGCTGCTGGACCGGAACCAGGACGCTACAGAT
GACACGGAGCTACAGAACATGAACGAGTACCTGAGCTCCTTCAAGGTGGCGCAGTACGTGGTGCGCGAGGAGGACGGCGTGGCATGATGT
CTCAGGGCCAGAGGCCGGTCACACCCATCCCTGATGTCCAGTCCTCCAAAGGGGGGAACTTGGCCGCCAGTGCAAAGAAGAAGCACGGTA
GCACCCCGCCAGGCCTTCAGCCGCGCCCACCGCATCGGCCAGAACAAGAAGGTGATGATCTACCGCTTCGTGACTCGGGCCTCGGTGGAG
GAGCGCATCACGCAGGTGGCCAAGCGCAAGATGATGCTCACCCACCTGGTGGTGCGGCCCGGCCTCGGCTCCAAGTCGGGGTCCATGACC
AAGCAGGAGCTGGACGACATCCTCAAGTTCGGCACGGAGGAACTCTTCAAGGACGACGTGGAGGCCCCCGGGGCCCAGCAGTTCTGCTTC
CTCCTCTCAACCCGGGCAGGTGGTCTGGGCATCAACCTGGCCACGGCGGACACTGTCATCATCTACGACTCGGACTGGAACCCGCACAAT
GACATCCAGATGACCAAGATGCTGGACCTCCTGGAGGACTTCCTGGAGTACGAAGGCTACAAGTATGAGCGGATTGATGGTGGCATCACC
GGGGGCCTCCGGCAGGAGGCAATCGACAGATTCAATGGAGGCCCCTGTCTTGCCCAATGGCTCCTACGATGGAAGCTCCCTGGTCAAGTC
TTCAGGGAAGCTCATGCTGCTACAGAAGATGCTGAAGAAACTGCGGGATGAGGGGCACCGTGTGCTCATCTTCTCCCAGGAAGTACTACA
AGTTCATCCTCACACGGAACTTTGAGGCACTGAACTCCAAGGGGGGCGGGAACCAAGTATCGCTGCTCAACATCATGATGGACCTGAAAA
AGTGCTGCAACCACCCCTACCTCTTCCCTGTGGCTGCCGTGCAACCTGGAGGGCTTCCTGGAGGAGTTTGCTGACATCTCCAAGGAAGAC
CAGATCAAGAAGCTGCATGACCTGCTGGGGCCGCACATGCTCAGGCGGCTCAAGGCTGACGTGTTCAAGAACATGCCGGCCAAGACCGAG
CTCATTGTCCGGGTGGAGCTGAGCCAGATGCAGAATTTTTTAGGGTCTTAAACAGCTACAAGATTGATTACAAGCTGCTGCTGACAGGGA
CCCCCCTTCAGAACAACCTGGAGGAGCTGTTCCATCTCCTCAACTTCCTGACTCCAGAGAGGTTCAAAAAGAAGTGCAGATCAAATTCCA
CGTGCTGCTCACCTCCTATGAGCTCATCACCATTGACCAGGCCATCCTGGGCTCCATCGAGTGGGCCTGCCTGGTGGTAGATGAGGCCCA
CCGCCTCAAGAACAACCAGTCCAAGGGCCACTCCAAAGGGCCCTACCTGGTTAGCGCGCCCCTCTCCACCATCATCAACTGGGAACGCGA
GTTTGAGATGTGGGCGCCCGACTTCTACGTGGTCACCTACACGGGGGACAAGGAGAGCCGCTCGGTGATTCGGGAGAACGAGTTTTCCTT
TGAGGACAACGCCATTCGGAGTGGGAAGAAGGTATTCCGTATGAAGCCCACGGTCAAGTTCGACAAGCAGCCATGGTACATCGACTCCAC
AGGCGGCACACTGCACCCGTACCAGCTGGAGGGCCTCAACTGGCTGCGCTTCTCTTGGGCCCAGGGCACTGACACCATCCTGGCCGATGA
GATGGGTCTGGGCAAGACGGTGCAGACCATCGTGTTCCTTTACTCCCTCTACAAGGAGGGAGCTGATGCTGGGAGAAGACACCAGGCTGC
CCAAGAGGCTGCTCAAGAAGGGCAAGAAGCTGAGGGACGACAAGCAGGAGAAGCCGCCGGACACGCCCATTGTGGACCTTTGACAAGAAG
GGGGATGTGCACTACCTGATCAAGTGGAAAGACCTGCCCTACGACCAGTGCACCTGGGAGATCGATGACATCGACATCCCCTACTACGAC
AACCTCAAGCAGGCCTACTGGGGCCACAGCTGGAGCTGTACCACACGGTGATGTATCGCAACTACCAAAGAAAGAACGACATGGATGAGC
CGCCCCCCTTTGACTACGGCTCTGGGGATGAAGACGGCAAGAGCGAGAAGAGGAAGAACAAGGACCCCCTCTATGCCAAGATGGAGGAGC
GCTTCTACCGCTATGGCATCAAGCCAGAGTGGATGATGATTCACCGAATCCTGAACCATAGTGCCCCCCACTGAAGGGCAAAGTCCAGCG
GATTCTACACTGGAGGTGGACGGAGCCCCCTGCCCCCTTCATGGTGGGGCTGCCGGGGCCTGACGTGGAGCCCAGCCTCCCTCCACCTAA
GCCCCTGGAGGGCATCCCTGAGAGAGAGTTCTTTGTCAAGTGGGCAGGGCTGTCCTACTGGCATTGCTCCTGGGTGAAGGAGCTACAGGA
GAAGGAGGGGATCCAGTGGGAGCCGAAGGACGACGACGATGAAGAGGAGGAGGGCGGCTGCGAGGAGGAGGAGGACGACCACATGGAGTT
CTGCCGCGTGTGCAAGGACGGGGGCGAGCTGCTCTGCTGCGACGCCTGCCCCTCCTCCTACCACCTGCATTGCCTCAACCCGCCGCTGCC
CGAGATCCCAAACGGTGAATGGCTCTGCCCGCGCTGTACTTTGATGATGGTGACGGCTATGAGACAGACCACCAGGATTACTGTGAGGTG
TGCCAGCAGGGTGGGGAGATCATCCTGTGCGACACCTGCCCGAGGGCCTACCATCTCGTATGCCTGGACCCAGAGCTGGAGAAGGCTCCC
GAGGGCAAGTGGAGCTGCCCCCACTGTAGTGAAGAAGATGAGAGGGAGGAGTCGGACTTCGACAGCGCCAGCATCCACAGTGCCTCCGTG
CGCTCCGAATGCTCTGCAGCCCTGGGCAAGAAGAGCAAGAGGAGGCGCAAGAAGAAGAGGAGGCCTGGAGTGAGGAAGAAGATCAAAGGC
TCCAAAGATGGGAAGAAAAAGGGCAAAGGGAAAAAGACGGCCGGGCTCAAGTTCCGCTTCGGGGGGATCAGCAACAAGAGGAAGAAAGGC
TCCTCGGGTGGCTGCGGCTGTAGAGACGGTCACCATCTCCCCTCCGCTAGCCGTCAGCCCCCCGCAGGTGCCCCAGCCTGTGCCTATCCG

>2856_2856_1_AGBL5-CHD5_AGBL5_chr2_27276821_ENST00000323064_CHD5_chr1_6214829_ENST00000262450_length(amino acids)=400AA_BP=
MIWPPARLEPPSTRQGRFGEPLSSPMVRPWLTFPLLPAKAGGRQVFALSLWGGGSSASRCLSPAQRILKALDSVTSGGPVAPALHSRQKR
MIPGRVGWGGGSTCLGATAALGLPSARGVVKGSDSCAPARRVMGPELAQETLALPCALGCLPCPPPEVEPGCPWGPGLVPFPCPWKGLPG
GFLPEAALLEGVGRVLPGGGLDPVPSADPSQPQHQGLAALFPARSALTSQNHLPTCGLLESHPLPRTLPLQVGDGDGEQVRPSLGLFVCD
PSPGPRSTWKAFLSLVLGPSQGRCLGVQNPGNVRKGLREKPSWAWGGGAHGLGLSSLERACLGLRGPGLGQDSPACVADTGAIAWPSLSP

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>2856_2856_2_AGBL5-CHD5_AGBL5_chr2_27276821_ENST00000360131_CHD5_chr1_6214829_ENST00000262450_length(transcript)=9563nt_BP=652nt
GGCACCGCGGCGCTCGGGTGTTTTTGGGGGCCCGGGTGGAGGGCCCGGGTGCCGGGGCCCAAGGTGCGGCCTCGCTAGCGGGAGAGGGAG
CGGGATCACCGGCCCGGAGAGAGCTCTCAGGGCCAGAGCGGGGCAGGAGGATGCTTTCCCAGCCCCACCATGGAGCTGCGCTGTGGGGGA
TTGCTGTTCAGTTCTCGCTTTGATTCAGGGAATCTAGCCCACGTGGAGAAGGTGGAATCTTTGTCCAGTGATGGGGAAGGGGTAGGAGGT
GGGGCGTCAGCCCTGACCAGTGGCATTGCCTCTTCCCCTGACTATGAATTCAACGTGTGGACCCGACCAGACTGTGCTGAAACGGAATTT
GAGAATGGGAACAGGTCATGGTTCTACTTCAGCGTCCGGGGAGGAATGCCAGGAAAACTCATCAAGATCAACATTATGAACATGAACAAG
CAGAGCAAGCTGTATTCCCAGGGCATGGCCCCCTTTGTGCGCACACTGCCCACCCGGCCACGCTGGGAACGCATTCGAGACCGGCCCACC
TTTGAGCCACCACCTTCTTCGCCTTCTGCTACCCCTTCTCCTACAGTGACTGCCAGGAACTGCTAAACCAGCTAGACCAGCGCTTTCCGG
AGAACCACCCTACCCATAGCAGCCACGCCTGCCGGGCCACCTGCCCGACCCACATGGGAGAGAAAAGCTGCCACCTTTTTAGGAGCCAGC
GCCACCTTGGGACAAAAAGGGAAACCTAGTAATGCCATCACATGGAGGACGAGGCCCAGCTCAGCTGGGCCAGAGCCCAGAAGTGCCACC
TCATCATAATTCAAGTGTTCTTCCACACAGCGTTGCCCCCACAACCACGCCGGACGTGCCCCCTCGCCACCTTTTCCAGACGACTTCTTA
GAAGAGATTTCATTTATTTGTACATCTTTTGCACTTTCCTATTGAAGACTTGAACACGTTTGTCTTGATAAAAGTTGGATGACGTATGGA
AGATTCGAACCTGCAGCACTGATGTCTCTTTACCGATGGGTTCCAGACCCAAGGTAGTCCTGGCACTGCCCTGTGGACTCAGCCCAGCTG
GGGAGGACATGGCGCCCGGTGCCCTAGGAGCCCTCAGTGTCCCCTACCTGACCTGTCTGCACCTGTGTGACAGCCCCTTCTGATTTGGCC
CCCTGCCCGCTTGGAGCCTCCCAGCACCAGACAGGGCAGGTTTGGGGAGCCGCTGTCCAGCCCTATGGTGAGACCCTGGCTGACATTTCC
CCTCCTTCCTGCCAAGGCTGGAGGCCGCCAGGTGTTTGCTCTCTCCTTGTGGGGAGGTGGATCCTCTGCCAGCAGGTGTCTGTCCCCGGC
CCAGCGCATCTTGAAGGCCCTGGACTCTGTTACCAGTGGGGGGCCTGTGGCCCCGGCTCTTCACAGCAGGCAGAAGCGTATGATCCCAGG
GAGGGTGGGCTGGGGGGGGGGCAGCACTTGCCTCGGAGCCACTGCTGCGTTGGGTTTGCCTTCTGCCAGAGGTGTGGTTAAGGGCAGTGA
TAGCTGCGCCCCAGCAAGGAGGGTCATGGGCCCTGAGCTGGCCCAGGAGACCCTGGCCCTGCCCTGTGCCCTGGGATGCCTACCCTGCCC
ACCTCCGGAGGTGGAACCGGGCTGCCCCTGGGGGCCTGGACTTGTCCCATTCCCCTGTCCCTGGAAAGGCCTTCCCGGGGGCTTTTTGCC
TGAGGCTGCACTCTTGGAAGGCGTGGGGAGAGTTCTGCCTGGAGGGGGACTGGACCCAGTGCCCTCTGCAGACCCCTCCCAGCCGCAGCA
CCAAGGGCTTGCTGCCTTGTTTCCTGCCAGGAGCGCCCTGACATCCCAAAACCATCTTCCCACATGTGGGTTGTTGGAATCCCACCCACT
CCCCCGGACCCTGCCCCTCCAAGTTGGGGACGGAGATGGGGAGCAGGTCAGGCCCTCCCTAGGCCTGTTTGTGTGTGATCCTTCTCCTGG
CCCCAGGTCGACCTGGAAGGCGTTTCTGAGTCTTGTACTGGGACCTTCCCAGGGAAGGTGCCTTGGGGTGCAGAATCCTGGGAATGTTAG
GAAAGGGCTGCGTGAAAAACCCAGCTGGGCCTGGGGTGGAGGTGCACACGGGCTGGGGCTCAGCTCCTTGGAGAGGGCCTGCCTGGGACT
GAGGGGGCCAGGGCTGGGTCAGGATTCACCAGCTTGTGTTGCAGACACTGGAGCGATTGCCTGGCCCTCCCTAAGCCCTATATGCCTCAC
TCATAATGAGGCTGTCTCTGAACCCCGGAGGGCGGGACCTACAAGTCCTTCCTCTTGGCGCATTCCCACACTCCAGTCTGGATCCAGGTC
TGCAAGGCCAGCCCGACCCTGACACTGCACGTGGGCGTAGTGGGGAGCACCCTGGAGTGGAGATGATTGTCAGCGGGCTCACATGTTATG
GTTCATCCACATGCGTGTTGTGTGCTCTGCGGTGCCTCCTGGCAAAGGGTCCTGGCTCGGGTCAGAAGCTCACTCCCGTGCCCTCGTCCC
CAAACAAGCAGTGGCAAGCACTGGGGTTGGCCCTCGTTGGGAGCAGTGCCCACCTTCCTTGGCCCACAGCAGATAGGTCCCGAGCAGCAG
GACTGGAGGCCTGTGGCGGTCAGGGCAGGGGTCTGTGTCTCCACCCCAAGGGCTGATGGTCCCTCCCCTGTGCGCCTTCCTCTCAGGCAG
GCTTGCTCTGTCCCTTCCTCTCTGCTTCCCTCCCAGGCCTCGCCAGGGCTCCCTTCTCCTCTGCCTGGTTAGACTCGGGCACCCAGGAAA
GCCTGGCCAGGGCTCCTTTGGGCCTGGGCCCCCTGCACTGCCTGGTCCAGAAGGGGTGGTGCTGTCCGTGGCCAGCACCCCGGGGCCCGG
GAGGGGTGGGCTACTAGAGTCAGAGCGGGTTTGGGGCTGACCAGTTTGGGAGAGGAGAAAAGATCTGAGAATGTCCTTCTTGGTTTGTCA
GTCATCTCTGCCAAAAGTGGTGATGGTGGTGTCCGTATGTTTGGCGTCTTTGGGCTGGGTTTGGTTTTTGCTGCTGGTAGAATCAGGGTC
CTCGGGCATGAACGCGAGCCCAAAGTGCCAGTCTGCGATTGGAAATTTCCAGCCACTTTAAGCCAGTGCTGAGTAGGGCTTCTGCAGAGC
CATGTTTGAGCCAAGGTCTTGGAAGGCATTGCCCCATGGGCTCAGGTGACTCGGGGTGGAGTGAGCACGTCTGCAGGGCCCTCTCATACA
CGCCTGAGGCAGAAGCAGCGTCCCCCGTGAAAGCCACCTTCCGAAGCTCCTGCGTTTTTTGCAAACTTGGCTTCCCCCAGGGGCAGGCTG
GACTTTCCCTGCCCCCTATGATTGAAGTCCTCCTGCTTTTGGGGGCTGCCTTCCCAGAGTCCCCCGGGTGCTCCCCTGCCGAGGTCAGGA
GCTGACCAAGCCTTGGCCCGGTGACACCTGCAGCCCTCACTCCTGTCATCCCAGGACACTTGAGGCCCAAGGAGGTGGAGTGGAGAGTGG
GCTCGGGTACATGGGAGCCAGAAGCCAGATGGACTTGGTCAAGTGTCGGTCACTTGGAGCCTCCAGTGTGCGTCAGGGTCTGTGGGCAGG
GGACAGGGCGTGGGTGGGGGCCGAGGCTGGCACGCCCCTCTGCCCTCACCGTCTTGGTGACCTGGCCTCGGCCCCTCCCCCAAGTCTCTT
CTGTGCAAGGCCCGCCTCGGCCTCGGCAGCTGGTTCCTGTCCTGTTTTCTGTGTCTGAAAGTTTACAGGTTGTGGTGCATCAGCCCAAAC
TCACTGGCGTTGTGTTTTTTTTTTCTTTAATTTTCAGATTTTTTTTTTAAACAAAGTATTTTTTTAGGTGCGATAACCCAGAAAGGGCCC
GTTGGGTGTGTGTGTGTGTCCTGAACTCCTCAAGCAGCGATTGGAGCCCAAGCACCCCTGGAGAGGAAGGGAGGGTCCCCACTGGCCCGT
GGGGTCTGAGTTCAGGGGTGTGGAGGGAGCAGACTCCACCGGCCCAGGCCCAGCTAAGAGGGGGCCGACCCCTTTCCCCAGGCACAGCCC
CAGGCTGGCAAAGGGAGGGCCCTGGGCTGGGTGCAAGGCGCGCCAGGAGTCCCAGCCAGGGTGGCCCCGGCGGGGGCGGGTCCAGCTTTG
GAAGCCAGGCTCCCCTGTGAGCCGTGGCTTGTCTGGTCTTCGCCCACGGGAGGCTGGACAGAGGCTGTAGCCAACACAATCACCTTTACT
TTGTACTCTGTGTGTATGTTTTGGTTTTCTGTGTTTTAATAAATCCTTTGGGAAAGGATATCTAGCCGTCCTCGAGACTTCCCTGTGTTG
CAGCGCTCATTTCCAGCTGAGGGCGCTTTCGGCTCCTCCCAGATGTACAGCAACAACTTTGGGCCCAACTTCCGGGGCCCTGGACCGGGA
GGGATTGTCAACTACAACCAGATGCCCCTGGGGCCCTATGTGACCGTCCTGAACCAGCTGGAGGAGCTGCTGAGCGACATGAAGGCCGAC
GTGACCCGGCTGCCATCCATGCTGTCCCGCATCCCCCCGGTGGCCGCCCGGCTGCAGATGTCGGAGCGCAGCATCCTGAGCCGCCTGACC
AACCGCGCCGGGGACCCCACCATCCAGCAGCTGCTGGAGCAGGCGTTGGTCATTGAGGAGCAGCTCCGGAGGGCCGCGTACCTGAACATG
ACGCAGGACCCCAACCACCCCGCCATGGCCCTCAACGCCCGCCTGGCTGAAGTGGAGTGCCTCGCCGAGAGCCACCAGCACCTGTCCAAG
GAGTCCCTTGCTGGGAACAAGCCTGCCAATGCCGTCCTGCACAAGGGCACGGCTACGCCCGCTGGCAGGACATCCAGAATGACCCACGGT
ACATGATCCTCAACGAGCCCTTCAAGTCTGAGGTCCACAAGGGCAACTACCTGGAGATGAAGAACAAGTTCCTGGCCCGCAGGTTTAAGA
GTTGCACACGCTGTGGCAGAACGAGGAGCGGGCTGCTGTATCCTCTGGGAAAATCTACGACATCTGGCACCGGCGCCATGACTACTGGCT
GCTGGCGGGCATCGTGACATGACACCAAGGCTGAGGAGAAGGAGCCCATTGAAACACAGCAAAATGGTGACAAAGAGGAAGATGACGAGG
GGAAGAAGGAGGACAAGAAGGGGAAATTCAAGTTCATGTTCAACATCGCGGACGGGGGCTTCACGGAGGAGGTGCTTCCTGAGAAGGAGA
AGATCCTGGACAAGCTGGAGCTGAGCTTGATCCACAGCAGAGGGGACAGTTCCGAACTCAGGCCAGGCCCTTCCAGCCGCCTTGGATAGA
GTGGAGAGTGAGGACAAGCACGAGAGCCCAGCCAGCAAGGAGAGAGCCCGAGAGGAGCGGCCAGAGGAGACGGAGAAGGCCCCGCCCTCC
CCGGAGCAGCTGCCGAGAGACAAAATGGAAGCCCAGCTGGGCTACATGGATGAGAAAGACCCCGGGGCACAGAAGCCAAGGCAGCCCCTG
GAAGTCCAGGTTCAGGAGTTTGAGCATGTCAACGGGAAGTACAGCACCCCAGACTTGATCCCTGAGGGGCCCGAGGGGAAGAAGTCGGGC
GAGGTGATCTCCTCGGACCCCAACACACCAGTGCCCGCCAGCCCTGCCCACCTCCTGCCAGCCCCGCTGGGCCTGCCAGAGCCTATGTGT
CCCTCTTCATGCGGCACCTGTGTGAGCCGGGGGCGGATGGTGCAGAGACCTTCGCAGACGGCGTGCCCCGGGAGGGCCTCTCCAGGCAGC
ACGTGCTGACCCGCATCGGGGTCATGTCACTAGTTAGGAAGAAGGTGCTGGGCTTCAATGCCCGACAGCGGAAGGCCTTTCTGAACGCCA
TCATGCGCTGGGGCATGCCCCCGCAGGACGCCTTCAACTCCCACTGGCTGGTGCGGGACCTTCGAGGGAAGAGCGAGAAGGAGTTTAGGT
GGACGACGACAATCCCGGAGGCAGCTGAAGAGTGACAGGGACAAGCCCCTGCCCCCGCTTCTCGCCCGAGTTGGTGGCAACATCGAGAGT
GGCAGGATGAGCTCTCTGATAACCAGTCAGAATATTCCATTGGCTCTGAGGATGAGGATGAGGACTTTGAAGAGAGGCCGGAAGGGCAGA
GAGGAGGTGGAGCGGGAAATCATCAAGCAGGAGGAGAACGTGGACCCCGACTACTGGGAGAAGCTGCTGCGGCACCACTATGAGCAGCAG
CAGGAGGACCTGGCCCGCAACCTGGGCAAGGGCAAGCGCATCCGCAAGCAGGTCAACTACAACGATGCCTCCCAGGAGGACCAGGGTGAC
AACAAGGACGTGGAGGACAGCAGTGTGATCCACTATGACGATGCGGCCATCTCCAAGCTGCTGGACCGGAACCAGGACGCTACAGATGAC
ACGGAGCTACAGAACATGAACGAGTACCTGAGCTCCTTCAAGGTGGCGCAGTACGTGGTGCGCGAGGAGGACGGCGTGGCATGATGTCTC
AGGGCCAGAGGCCGGTCACACCCATCCCTGATGTCCAGTCCTCCAAAGGGGGGAACTTGGCCGCCAGTGCAAAGAAGAAGCACGGTAGCA
CCCCGCCAGGCCTTCAGCCGCGCCCACCGCATCGGCCAGAACAAGAAGGTGATGATCTACCGCTTCGTGACTCGGGCCTCGGTGGAGGAG
CGCATCACGCAGGTGGCCAAGCGCAAGATGATGCTCACCCACCTGGTGGTGCGGCCCGGCCTCGGCTCCAAGTCGGGGTCCATGACCAAG
CAGGAGCTGGACGACATCCTCAAGTTCGGCACGGAGGAACTCTTCAAGGACGACGTGGAGGCCCCCGGGGCCCAGCAGTTCTGCTTCCTC
CTCTCAACCCGGGCAGGTGGTCTGGGCATCAACCTGGCCACGGCGGACACTGTCATCATCTACGACTCGGACTGGAACCCGCACAATGAC
ATCCAGATGACCAAGATGCTGGACCTCCTGGAGGACTTCCTGGAGTACGAAGGCTACAAGTATGAGCGGATTGATGGTGGCATCACCGGG
GGCCTCCGGCAGGAGGCAATCGACAGATTCAATGGAGGCCCCTGTCTTGCCCAATGGCTCCTACGATGGAAGCTCCCTGGTCAAGTCTTC
AGGGAAGCTCATGCTGCTACAGAAGATGCTGAAGAAACTGCGGGATGAGGGGCACCGTGTGCTCATCTTCTCCCAGGAAGTACTACAAGT
TCATCCTCACACGGAACTTTGAGGCACTGAACTCCAAGGGGGGCGGGAACCAAGTATCGCTGCTCAACATCATGATGGACCTGAAAAAGT
GCTGCAACCACCCCTACCTCTTCCCTGTGGCTGCCGTGCAACCTGGAGGGCTTCCTGGAGGAGTTTGCTGACATCTCCAAGGAAGACCAG
ATCAAGAAGCTGCATGACCTGCTGGGGCCGCACATGCTCAGGCGGCTCAAGGCTGACGTGTTCAAGAACATGCCGGCCAAGACCGAGCTC
ATTGTCCGGGTGGAGCTGAGCCAGATGCAGAATTTTTTAGGGTCTTAAACAGCTACAAGATTGATTACAAGCTGCTGCTGACAGGGACCC
CCCTTCAGAACAACCTGGAGGAGCTGTTCCATCTCCTCAACTTCCTGACTCCAGAGAGGTTCAAAAAGAAGTGCAGATCAAATTCCACGT
GCTGCTCACCTCCTATGAGCTCATCACCATTGACCAGGCCATCCTGGGCTCCATCGAGTGGGCCTGCCTGGTGGTAGATGAGGCCCACCG
CCTCAAGAACAACCAGTCCAAGGGCCACTCCAAAGGGCCCTACCTGGTTAGCGCGCCCCTCTCCACCATCATCAACTGGGAACGCGAGTT
TGAGATGTGGGCGCCCGACTTCTACGTGGTCACCTACACGGGGGACAAGGAGAGCCGCTCGGTGATTCGGGAGAACGAGTTTTCCTTTGA
GGACAACGCCATTCGGAGTGGGAAGAAGGTATTCCGTATGAAGCCCACGGTCAAGTTCGACAAGCAGCCATGGTACATCGACTCCACAGG
CGGCACACTGCACCCGTACCAGCTGGAGGGCCTCAACTGGCTGCGCTTCTCTTGGGCCCAGGGCACTGACACCATCCTGGCCGATGAGAT
GGGTCTGGGCAAGACGGTGCAGACCATCGTGTTCCTTTACTCCCTCTACAAGGAGGGAGCTGATGCTGGGAGAAGACACCAGGCTGCCCA
AGAGGCTGCTCAAGAAGGGCAAGAAGCTGAGGGACGACAAGCAGGAGAAGCCGCCGGACACGCCCATTGTGGACCTTTGACAAGAAGGGG
GATGTGCACTACCTGATCAAGTGGAAAGACCTGCCCTACGACCAGTGCACCTGGGAGATCGATGACATCGACATCCCCTACTACGACAAC
CTCAAGCAGGCCTACTGGGGCCACAGCTGGAGCTGTACCACACGGTGATGTATCGCAACTACCAAAGAAAGAACGACATGGATGAGCCGC
CCCCCTTTGACTACGGCTCTGGGGATGAAGACGGCAAGAGCGAGAAGAGGAAGAACAAGGACCCCCTCTATGCCAAGATGGAGGAGCGCT
TCTACCGCTATGGCATCAAGCCAGAGTGGATGATGATTCACCGAATCCTGAACCATAGTGCCCCCCACTGAAGGGCAAAGTCCAGCGGAT
TCTACACTGGAGGTGGACGGAGCCCCCTGCCCCCTTCATGGTGGGGCTGCCGGGGCCTGACGTGGAGCCCAGCCTCCCTCCACCTAAGCC
CCTGGAGGGCATCCCTGAGAGAGAGTTCTTTGTCAAGTGGGCAGGGCTGTCCTACTGGCATTGCTCCTGGGTGAAGGAGCTACAGGAGAA
GGAGGGGATCCAGTGGGAGCCGAAGGACGACGACGATGAAGAGGAGGAGGGCGGCTGCGAGGAGGAGGAGGACGACCACATGGAGTTCTG
CCGCGTGTGCAAGGACGGGGGCGAGCTGCTCTGCTGCGACGCCTGCCCCTCCTCCTACCACCTGCATTGCCTCAACCCGCCGCTGCCCGA
GATCCCAAACGGTGAATGGCTCTGCCCGCGCTGTACTTTGATGATGGTGACGGCTATGAGACAGACCACCAGGATTACTGTGAGGTGTGC
CAGCAGGGTGGGGAGATCATCCTGTGCGACACCTGCCCGAGGGCCTACCATCTCGTATGCCTGGACCCAGAGCTGGAGAAGGCTCCCGAG
GGCAAGTGGAGCTGCCCCCACTGTAGTGAAGAAGATGAGAGGGAGGAGTCGGACTTCGACAGCGCCAGCATCCACAGTGCCTCCGTGCGC
TCCGAATGCTCTGCAGCCCTGGGCAAGAAGAGCAAGAGGAGGCGCAAGAAGAAGAGGAGGCCTGGAGTGAGGAAGAAGATCAAAGGCTCC
AAAGATGGGAAGAAAAAGGGCAAAGGGAAAAAGACGGCCGGGCTCAAGTTCCGCTTCGGGGGGATCAGCAACAAGAGGAAGAAAGGCTCC
TCGGGTGGCTGCGGCTGTAGAGACGGTCACCATCTCCCCTCCGCTAGCCGTCAGCCCCCCGCAGGTGCCCCAGCCTGTGCCTATCCGCAA

>2856_2856_2_AGBL5-CHD5_AGBL5_chr2_27276821_ENST00000360131_CHD5_chr1_6214829_ENST00000262450_length(amino acids)=400AA_BP=
MIWPPARLEPPSTRQGRFGEPLSSPMVRPWLTFPLLPAKAGGRQVFALSLWGGGSSASRCLSPAQRILKALDSVTSGGPVAPALHSRQKR
MIPGRVGWGGGSTCLGATAALGLPSARGVVKGSDSCAPARRVMGPELAQETLALPCALGCLPCPPPEVEPGCPWGPGLVPFPCPWKGLPG
GFLPEAALLEGVGRVLPGGGLDPVPSADPSQPQHQGLAALFPARSALTSQNHLPTCGLLESHPLPRTLPLQVGDGDGEQVRPSLGLFVCD
PSPGPRSTWKAFLSLVLGPSQGRCLGVQNPGNVRKGLREKPSWAWGGGAHGLGLSSLERACLGLRGPGLGQDSPACVADTGAIAWPSLSP

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Fusion Gene PPI Analysis for AGBL5-CHD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AGBL5-CHD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AGBL5-CHD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGBL5C4310759RETINITIS PIGMENTOSA 754CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAGBL5C0035334Retinitis Pigmentosa1ORPHANET
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0027819Neuroblastoma1CTD_human