![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACTB-FN1 (FusionGDB2 ID:HG60TG2335) |
Fusion Gene Summary for ACTB-FN1 |
![]() |
Fusion gene information | Fusion gene name: ACTB-FN1 | Fusion gene ID: hg60tg2335 | Hgene | Tgene | Gene symbol | ACTB | FN1 | Gene ID | 60 | 2335 |
Gene name | actin beta | fibronectin 1 | |
Synonyms | BRWS1|PS1TP5BP1 | CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF | |
Cytomap | ('ACTB')('FN1') 7p22.1 | 2q35 | |
Type of gene | protein-coding | protein-coding | |
Description | actin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actin | fibronectincold-insoluble globulinepididymis secretory sperm binding proteinmigration-stimulating factor | |
Modification date | 20200327 | 20200329 | |
UniProtAcc | P60709 | P02751 | |
Ensembl transtripts involved in fusion gene | ENST00000331789, ENST00000464611, | ENST00000331789, ENST00000464611, | |
Fusion gene scores | * DoF score | 68 X 54 X 18=66096 | 35 X 39 X 9=12285 |
# samples | 83 | 42 | |
** MAII score | log2(83/66096*10)=-6.31530781862183 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(42/12285*10)=-4.8703647195834 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACTB [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACTB(5567373)-FN1(216293751), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACTB | GO:0098974 | postsynaptic actin cytoskeleton organization | 18341992 |
Tgene | FN1 | GO:0001932 | regulation of protein phosphorylation | 11792823 |
Tgene | FN1 | GO:0008284 | positive regulation of cell proliferation | 25834989 |
Tgene | FN1 | GO:0010628 | positive regulation of gene expression | 25834989 |
Tgene | FN1 | GO:0018149 | peptide cross-linking | 3997886 |
Tgene | FN1 | GO:0034446 | substrate adhesion-dependent cell spreading | 16236823 |
Tgene | FN1 | GO:0035987 | endodermal cell differentiation | 23154389 |
Tgene | FN1 | GO:0048146 | positive regulation of fibroblast proliferation | 25834989 |
Tgene | FN1 | GO:0051702 | interaction with symbiont | 12167537|12421310|19429745 |
Tgene | FN1 | GO:0070372 | regulation of ERK1 and ERK2 cascade | 11792823 |
Tgene | FN1 | GO:1901166 | neural crest cell migration involved in autonomic nervous system development | 26571399 |
Tgene | FN1 | GO:1904237 | positive regulation of substrate-dependent cell migration, cell attachment to substrate | 25834989 |
Tgene | FN1 | GO:2001202 | negative regulation of transforming growth factor-beta secretion | 25834989 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Top |
Fusion Gene ORF analysis for ACTB-FN1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for ACTB-FN1 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Top |
Fusion Protein Features for ACTB-FN1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:5567373/:216293751) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
ACTB | FN1 |
FUNCTION: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). {ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947}. | FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). {ECO:0000250|UniProtKB:P11276, ECO:0000269|PubMed:3024962, ECO:0000269|PubMed:34089617, ECO:0000269|PubMed:3593230, ECO:0000269|PubMed:3900070, ECO:0000269|PubMed:7989369}.; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {ECO:0000269|PubMed:11209058, ECO:0000269|PubMed:15665290, ECO:0000269|PubMed:19379667, ECO:0000269|PubMed:8114919}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for ACTB-FN1 |
![]() |
Top |
Fusion Gene PPI Analysis for ACTB-FN1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ACTB-FN1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | FN1 | P02751 | DB08888 | Ocriplasmin | Cleavage | Biotech | Approved |
Tgene | FN1 | P02751 | DB08888 | Ocriplasmin | Cleavage | Biotech | Approved |
Tgene | FN1 | P02751 | DB14548 | Zinc sulfate, unspecified form | Ligand|Modulator | Small molecule | Approved|Experimental |
Tgene | FN1 | P02751 | DB14548 | Zinc sulfate, unspecified form | Ligand|Modulator | Small molecule | Approved|Experimental |
Tgene | FN1 | P02751 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
Tgene | FN1 | P02751 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
Tgene | FN1 | P02751 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
Tgene | FN1 | P02751 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
Tgene | FN1 | P02751 | DB14533 | Zinc chloride | Ligand|Modulator | Small molecule | Approved|Investigational |
Tgene | FN1 | P02751 | DB14533 | Zinc chloride | Ligand|Modulator | Small molecule | Approved|Investigational |
Top |
Related Diseases for ACTB-FN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACTB | C1855722 | Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation | 6 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | ACTB | C1846331 | Juvenile-onset dystonia | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | ACTB | C1853623 | Fryns-Aftimos Syndrome | 2 | GENOMICS_ENGLAND |
Hgene | ACTB | C2239176 | Liver carcinoma | 2 | CTD_human |
Hgene | ACTB | C0003129 | Anoxemia | 1 | CTD_human |
Hgene | ACTB | C0003130 | Anoxia | 1 | CTD_human |
Hgene | ACTB | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | ACTB | C0005818 | Blood Platelet Disorders | 1 | GENOMICS_ENGLAND |
Hgene | ACTB | C0007097 | Carcinoma | 1 | CTD_human |
Hgene | ACTB | C0009363 | Congenital ocular coloboma (disorder) | 1 | CTD_human |
Hgene | ACTB | C0013393 | Dysostoses | 1 | CTD_human |
Hgene | ACTB | C0013421 | Dystonia | 1 | CTD_human |
Hgene | ACTB | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0018784 | Sensorineural Hearing Loss (disorder) | 1 | CTD_human |
Hgene | ACTB | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | ACTB | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ACTB | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ACTB | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | ACTB | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ACTB | C0086743 | Osteoarthrosis Deformans | 1 | CTD_human |
Hgene | ACTB | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | ACTB | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
Hgene | ACTB | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
Hgene | ACTB | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
Hgene | ACTB | C0205699 | Carcinomatosis | 1 | CTD_human |
Hgene | ACTB | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | ACTB | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Hgene | ACTB | C0263579 | Pigmented hairy epidermal nevus | 1 | ORPHANET |
Hgene | ACTB | C0265541 | Cranioschisis | 1 | CTD_human |
Hgene | ACTB | C0272183 | Qualitative abnormality of granulocyte | 1 | GENOMICS_ENGLAND |
Hgene | ACTB | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | ACTB | C0393588 | Dystonia, Paroxysmal | 1 | CTD_human |
Hgene | ACTB | C0393610 | Dystonia, Diurnal | 1 | CTD_human |
Hgene | ACTB | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Hgene | ACTB | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
Hgene | ACTB | C0700292 | Hypoxemia | 1 | CTD_human |
Hgene | ACTB | C0751093 | Dystonia, Limb | 1 | CTD_human |
Hgene | ACTB | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | ACTB | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
Hgene | ACTB | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | ACTB | C1691779 | Sensory hearing loss | 1 | CTD_human |
Hgene | ACTB | C1858042 | Becker Nevus Syndrome | 1 | ORPHANET |
Hgene | ACTB | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | ACTB | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | ACTB | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Hgene | ACTB | C4554007 | Uveoretinal Coloboma | 1 | CTD_human |
Tgene | C0020538 | Hypertensive disease | 2 | CTD_human | |
Tgene | C0432221 | Spondylometaphyseal dysplasia, 'corner fracture' type | 2 | GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0000786 | Spontaneous abortion | 1 | CTD_human | |
Tgene | C0000822 | Abortion, Tubal | 1 | CTD_human | |
Tgene | C0003504 | Aortic Valve Insufficiency | 1 | CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human;UNIPROT | |
Tgene | C0007097 | Carcinoma | 1 | CTD_human | |
Tgene | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human | |
Tgene | C0010346 | Crohn Disease | 1 | CTD_human | |
Tgene | C0011849 | Diabetes Mellitus | 1 | CTD_human | |
Tgene | C0011881 | Diabetic Nephropathy | 1 | CTD_human | |
Tgene | C0017636 | Glioblastoma | 1 | CTD_human | |
Tgene | C0017667 | Nodular glomerulosclerosis | 1 | CTD_human | |
Tgene | C0017668 | Focal glomerulosclerosis | 1 | CTD_human | |
Tgene | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human | |
Tgene | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human | |
Tgene | C0027626 | Neoplasm Invasiveness | 1 | CTD_human | |
Tgene | C0034069 | Pulmonary Fibrosis | 1 | CTD_human | |
Tgene | C0041956 | Ureteral obstruction | 1 | CTD_human | |
Tgene | C0085762 | Alcohol abuse | 1 | PSYGENET | |
Tgene | C0086432 | Hyalinosis, Segmental Glomerular | 1 | CTD_human | |
Tgene | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human | |
Tgene | C0156147 | Crohn's disease of large bowel | 1 | CTD_human | |
Tgene | C0205696 | Anaplastic carcinoma | 1 | CTD_human | |
Tgene | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human | |
Tgene | C0205698 | Undifferentiated carcinoma | 1 | CTD_human | |
Tgene | C0205699 | Carcinomatosis | 1 | CTD_human | |
Tgene | C0267380 | Crohn's disease of the ileum | 1 | CTD_human | |
Tgene | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human | |
Tgene | C0345967 | Malignant mesothelioma | 1 | CTD_human | |
Tgene | C0678202 | Regional enteritis | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C0949272 | IIeocolitis | 1 | CTD_human | |
Tgene | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C1621958 | Glioblastoma Multiforme | 1 | CTD_human | |
Tgene | C1866075 | GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder) | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C3830362 | Early Pregnancy Loss | 1 | CTD_human | |
Tgene | C3888104 | Glomerulopathy with fibronectin deposits | 1 | CTD_human;ORPHANET | |
Tgene | C4552766 | Miscarriage | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human | |
Tgene | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |