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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS6KB1-TEX2 (FusionGDB2 ID:HG6198TG55852)

Fusion Gene Summary for RPS6KB1-TEX2

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KB1-TEX2
Fusion gene ID: hg6198tg55852
HgeneTgene
Gene symbol

RPS6KB1

TEX2

Gene ID

6198

55852

Gene nameribosomal protein S6 kinase B1testis expressed 2
SynonymsPS6K|S6K|S6K-beta-1|S6K1|STK14A|p70 S6KA|p70(S6K)-alpha|p70-S6K|p70-alphaHT008|TMEM96
Cytomap('RPS6KB1')('TEX2')

17q23.1

17q23.3

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase beta-1p70 S6 kinase, alpharibosomal protein S6 kinase Iribosomal protein S6 kinase, 70kDa, polypeptide 1serine/threonine kinase 14 alphaserine/threonine-protein kinase 14Atestis-expressed protein 2testis expressed sequence 2testis-expressed sequence 2 proteintransmembrane protein 96
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000225577, ENST00000393021, 
ENST00000406116, ENST00000443572, 
ENST00000587061, 
Fusion gene scores* DoF score14 X 17 X 14=333212 X 12 X 5=720
# samples 4718
** MAII scorelog2(47/3332*10)=-2.82565573880055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/720*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS6KB1 [Title/Abstract] AND TEX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS6KB1(57990165)-TEX2(62291602), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KB1

GO:0031667

response to nutrient levels

29750193

HgeneRPS6KB1

GO:0031929

TOR signaling

12150926

HgeneRPS6KB1

GO:0071363

cellular response to growth factor stimulus

17936702



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SN-01ARPS6KB1chr17

57990164

+TEX2chr17

62291601

-
ChimerDB4BRCATCGA-A1-A0SN-01ARPS6KB1chr17

57990165

-TEX2chr17

62291602

-
ChimerDB4BRCATCGA-A1-A0SN-01ARPS6KB1chr17

57990165

+TEX2chr17

62291602

-
ChimerDB4BRCATCGA-A1-A0SNRPS6KB1chr17

57990165

+TEX2chr17

62291602

-


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Fusion Gene ORF analysis for RPS6KB1-TEX2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000225577ENST00000258991RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000225577ENST00000258991RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000225577ENST00000583097RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000225577ENST00000583097RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000225577ENST00000584379RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000225577ENST00000584379RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000393021ENST00000258991RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000393021ENST00000258991RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000393021ENST00000583097RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000393021ENST00000583097RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000393021ENST00000584379RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000393021ENST00000584379RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000406116ENST00000258991RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000406116ENST00000258991RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000406116ENST00000583097RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000406116ENST00000583097RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000406116ENST00000584379RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000406116ENST00000584379RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000443572ENST00000258991RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000443572ENST00000258991RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000443572ENST00000583097RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000443572ENST00000583097RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-5UTRENST00000443572ENST00000584379RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-5UTRENST00000443572ENST00000584379RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-intronENST00000225577ENST00000581812RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-intronENST00000225577ENST00000581812RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-intronENST00000393021ENST00000581812RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-intronENST00000393021ENST00000581812RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-intronENST00000406116ENST00000581812RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-intronENST00000406116ENST00000581812RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
5CDS-intronENST00000443572ENST00000581812RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
5CDS-intronENST00000443572ENST00000581812RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
intron-5UTRENST00000587061ENST00000258991RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
intron-5UTRENST00000587061ENST00000258991RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
intron-5UTRENST00000587061ENST00000583097RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
intron-5UTRENST00000587061ENST00000583097RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
intron-5UTRENST00000587061ENST00000584379RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
intron-5UTRENST00000587061ENST00000584379RPS6KB1chr17

57990165

+TEX2chr17

62291602

-
intron-intronENST00000587061ENST00000581812RPS6KB1chr17

57990164

+TEX2chr17

62291601

-
intron-intronENST00000587061ENST00000581812RPS6KB1chr17

57990165

+TEX2chr17

62291602

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RPS6KB1-TEX2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for RPS6KB1-TEX2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57990165/:62291602)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RPS6KB1-TEX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RPS6KB1-TEX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS6KB1-TEX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS6KB1-TEX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS6KB1C0020538Hypertensive disease1CTD_human
HgeneRPS6KB1C0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgeneRPS6KB1C0149721Left Ventricular Hypertrophy1CTD_human
HgeneRPS6KB1C0333641Atrophic1CTD_human
HgeneRPS6KB1C2931673Ceroid lipofuscinosis, neuronal 1, infantile1CTD_human