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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CLIP1-ZCCHC8 (FusionGDB2 ID:HG6249TG55596) |
Fusion Gene Summary for CLIP1-ZCCHC8 |
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Fusion gene information | Fusion gene name: CLIP1-ZCCHC8 | Fusion gene ID: hg6249tg55596 | Hgene | Tgene | Gene symbol | CLIP1 | ZCCHC8 | Gene ID | 6249 | 55596 |
Gene name | CAP-Gly domain containing linker protein 1 | zinc finger CCHC-type containing 8 | |
Synonyms | CLIP|CLIP-170|CLIP170|CYLN1|RSN | PFBMFT5 | |
Cytomap | ('CLIP1')('ZCCHC8') 12q24.31 | 12q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | CAP-Gly domain-containing linker protein 1cytoplasmic linker protein 1cytoplasmic linker protein 170 alpha-2cytoplasmic linker protein CLIP-170restin (Reed-Steinberg cell-expressed intermediate filament-associated protein) | zinc finger CCHC domain-containing protein 8TRAMP-like complex RNA-binding factor ZCCHC8zinc finger, CCHC domain containing 8 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P30622 | Q6NZY4 | |
Ensembl transtripts involved in fusion gene | ENST00000302528, ENST00000358808, ENST00000361654, ENST00000537178, ENST00000540338, ENST00000536634, ENST00000540539, ENST00000545889, | ||
Fusion gene scores | * DoF score | 22 X 22 X 13=6292 | 5 X 6 X 6=180 |
# samples | 31 | 8 | |
** MAII score | log2(31/6292*10)=-4.34317855014145 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CLIP1 [Title/Abstract] AND ZCCHC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CLIP1(122907068)-ZCCHC8(122958822), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-ZF-AA51-01A | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
ChimerDB4 | CESC | TCGA-ZJ-AAXN-01A | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
ChimerDB4 | CESC | TCGA-ZJ-AAXN | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
ChimerDB4 | HNSC | TCGA-P3-A6T7-01A | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
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Fusion Gene ORF analysis for CLIP1-ZCCHC8 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000302528 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-5UTR | ENST00000302528 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-5UTR | ENST00000358808 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-5UTR | ENST00000358808 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-5UTR | ENST00000361654 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-5UTR | ENST00000361654 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-5UTR | ENST00000537178 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-5UTR | ENST00000537178 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-5UTR | ENST00000540338 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-5UTR | ENST00000540338 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000302528 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000302528 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000358808 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000358808 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000361654 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000361654 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000537178 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000537178 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000540338 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5CDS-intron | ENST00000540338 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
5UTR-3CDS | ENST00000358808 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000358808 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000358808 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000358808 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000361654 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000361654 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000361654 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000361654 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000537178 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000537178 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000537178 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-3CDS | ENST00000537178 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
5UTR-5UTR | ENST00000358808 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-5UTR | ENST00000358808 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-5UTR | ENST00000358808 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-5UTR | ENST00000361654 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-5UTR | ENST00000361654 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-5UTR | ENST00000361654 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-5UTR | ENST00000537178 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-5UTR | ENST00000537178 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-5UTR | ENST00000537178 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-intron | ENST00000358808 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-intron | ENST00000361654 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
5UTR-intron | ENST00000537178 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-3CDS | ENST00000302528 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000302528 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000302528 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000302528 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000536634 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000536634 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000536634 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000536634 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000540338 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000540338 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000540338 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000540338 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000540539 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000540539 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000540539 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000540539 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000545889 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000545889 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000545889 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-3CDS | ENST00000545889 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
intron-5UTR | ENST00000302528 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000302528 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000302528 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000536634 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000536634 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-5UTR | ENST00000536634 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000536634 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000536634 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-5UTR | ENST00000540338 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000540338 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000540338 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000540539 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000540539 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-5UTR | ENST00000540539 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000540539 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000540539 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-5UTR | ENST00000545889 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000545889 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-5UTR | ENST00000545889 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000545889 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-5UTR | ENST00000545889 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-intron | ENST00000302528 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-intron | ENST00000536634 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-intron | ENST00000536634 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-intron | ENST00000536634 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-intron | ENST00000540338 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-intron | ENST00000540539 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-intron | ENST00000540539 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-intron | ENST00000540539 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-intron | ENST00000545889 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
intron-intron | ENST00000545889 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
intron-intron | ENST00000545889 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CLIP1-ZCCHC8 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CLIP1-ZCCHC8 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:122907068/:122958822) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CLIP1 | ZCCHC8 |
FUNCTION: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. | FUNCTION: Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CLIP1-ZCCHC8 |
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Fusion Gene PPI Analysis for CLIP1-ZCCHC8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CLIP1-ZCCHC8 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CLIP1-ZCCHC8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0020796 | Profound Mental Retardation | 1 | CTD_human | |
Tgene | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human | |
Tgene | C0917816 | Mental deficiency | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | CTD_human |