Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CFB-CFB (FusionGDB2 ID:HG629TG629)

Fusion Gene Summary for CFB-CFB

check button Fusion gene summary
Fusion gene informationFusion gene name: CFB-CFB
Fusion gene ID: hg629tg629
HgeneTgene
Gene symbol

CFB

CFB

Gene ID

629

629

Gene namecomplement factor Bcomplement factor B
SynonymsAHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2AHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2
Cytomap('CFB')('CFB')

6p21.33

6p21.33

Type of geneprotein-codingprotein-coding
Descriptioncomplement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor Bcomplement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor B
Modification date2020032720200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000497841, ENST00000425368, 
ENST00000456570, ENST00000477310, 
ENST00000556679, ENST00000375455, 
ENST00000399981, ENST00000417261, 
ENST00000419411, ENST00000419920, 
ENST00000424727, ENST00000426239, 
ENST00000427888, ENST00000433503, 
ENST00000436692, ENST00000455591, 
ENST00000459734, ENST00000460958, 
ENST00000465211, ENST00000473139, 
ENST00000474621, ENST00000489605, 
ENST00000425368, ENST00000456570, 
ENST00000477310, ENST00000556679, 
ENST00000497841, ENST00000375455, 
ENST00000399981, ENST00000417261, 
ENST00000419411, ENST00000419920, 
ENST00000424727, ENST00000426239, 
ENST00000427888, ENST00000433503, 
ENST00000436692, ENST00000455591, 
ENST00000459734, ENST00000460958, 
ENST00000465211, ENST00000473139, 
ENST00000474621, ENST00000489605, 
Fusion gene scores* DoF score10 X 8 X 4=32017 X 11 X 9=1683
# samples 1220
** MAII scorelog2(12/320*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1683*10)=-3.07296327155522
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CFB [Title/Abstract] AND CFB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCFB(31918515)-CFB(31917216), # samples:3
Anticipated loss of major functional domain due to fusion event.CFB-CFB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CFB-CFB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CFB-CFB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CFB-CFB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CFB-CFB seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CFB-CFB seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CFB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CFB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for CFB-CFB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CFB-CFB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CFB-CFB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:31918515/chr6:31917216)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCFBchr6:31917236chr6:31917281ENST00000399981019101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000399981019163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000399981019270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000039998101935_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000399981019477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000417261019101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000417261019163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000417261019270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000041726101935_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000417261019477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000419411018101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000419411018163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000419411018270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000041941101835_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000419411018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000419920018101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000419920018163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000419920018270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000041992001835_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000419920018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000424727019101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000424727019163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000424727019270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000042472701935_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000424727019477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000425368018101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000425368018163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000425368018270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000042536801835_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000425368018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000426239019101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000426239019163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000426239019270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000042623901935_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000426239019477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000427888018101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000427888018163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000427888018270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000042788801835_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000427888018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000433503018101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000433503018163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000433503018270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000043350301835_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000433503018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000436692018101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000436692018163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000436692018270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000043669201835_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000436692018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31917236chr6:31917281ENST00000455591019101_1600765.0DomainSushi 2
TgeneCFBchr6:31917236chr6:31917281ENST00000455591019163_2200765.0DomainSushi 3
TgeneCFBchr6:31917236chr6:31917281ENST00000455591019270_4690765.0DomainVWFA
TgeneCFBchr6:31917236chr6:31917281ENST0000045559101935_1000765.0DomainSushi 1
TgeneCFBchr6:31917236chr6:31917281ENST00000455591019477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000399981019101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000399981019163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000399981019270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000039998101935_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000399981019477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000417261019101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000417261019163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000417261019270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000041726101935_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000417261019477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000419411018101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000419411018163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000419411018270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000041941101835_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000419411018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000419920018101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000419920018163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000419920018270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000041992001835_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000419920018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000424727019101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000424727019163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000424727019270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000042472701935_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000424727019477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000425368018101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000425368018163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000425368018270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000042536801835_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000425368018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000426239019101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000426239019163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000426239019270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000042623901935_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000426239019477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000427888018101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000427888018163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000427888018270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000042788801835_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000427888018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000433503018101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000433503018163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000433503018270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000043350301835_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000433503018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000436692018101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000436692018163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000436692018270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000043669201835_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000436692018477_7570765.0DomainPeptidase S1
TgeneCFBchr6:31919767chr6:31919745ENST00000455591019101_1600765.0DomainSushi 2
TgeneCFBchr6:31919767chr6:31919745ENST00000455591019163_2200765.0DomainSushi 3
TgeneCFBchr6:31919767chr6:31919745ENST00000455591019270_4690765.0DomainVWFA
TgeneCFBchr6:31919767chr6:31919745ENST0000045559101935_1000765.0DomainSushi 1
TgeneCFBchr6:31919767chr6:31919745ENST00000455591019477_7570765.0DomainPeptidase S1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCFBchr6:31917236chr6:31917281ENST00000399981-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000399981-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000399981-119270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000399981-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000399981-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000417261-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000417261-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000417261-119270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000417261-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000417261-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000419411-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000419411-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000419411-118270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000419411-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000419411-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000419920-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000419920-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000419920-118270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000419920-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000419920-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000424727-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000424727-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000424727-119270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000424727-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000424727-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000425368-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000425368-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000425368-118270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000425368-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000425368-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000426239-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000426239-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000426239-119270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000426239-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000426239-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000427888-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000427888-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000427888-118270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000427888-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000427888-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000433503-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000433503-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000433503-118270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000433503-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000433503-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000436692-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000436692-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000436692-118270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000436692-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000436692-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31917236chr6:31917281ENST00000455591-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31917236chr6:31917281ENST00000455591-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31917236chr6:31917281ENST00000455591-119270_4690765.0DomainVWFA
HgeneCFBchr6:31917236chr6:31917281ENST00000455591-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31917236chr6:31917281ENST00000455591-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000399981-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000399981-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000399981-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000399981-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000399981-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000417261-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000417261-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000417261-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000417261-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000417261-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000419411-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000419411-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000419411-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000419411-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000419411-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000419920-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000419920-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000419920-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000419920-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000419920-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000424727-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000424727-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000424727-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000424727-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000424727-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000425368-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000425368-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000425368-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000425368-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000425368-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000426239-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000426239-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000426239-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000426239-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000426239-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000427888-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000427888-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000427888-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000427888-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000427888-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000433503-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000433503-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000433503-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000433503-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000433503-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000436692-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000436692-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000436692-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000436692-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000436692-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919767chr6:31919745ENST00000455591-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919767chr6:31919745ENST00000455591-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919767chr6:31919745ENST00000455591-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919767chr6:31919745ENST00000455591-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919767chr6:31919745ENST00000455591-119477_7570765.0DomainPeptidase S1


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Fusion Gene Sequence for CFB-CFB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CFB-CFB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CFB-CFB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CFB-CFB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCFBC2752038HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 45GENOMICS_ENGLAND;UNIPROT
HgeneCFBC2931788Atypical Hemolytic Uremic Syndrome3CTD_human;GENOMICS_ENGLAND
HgeneCFBC0017662Glomerulonephritis, Membranoproliferative1GENOMICS_ENGLAND
HgeneCFBC0019061Hemolytic-Uremic Syndrome1GENOMICS_ENGLAND
HgeneCFBC0024141Lupus Erythematosus, Systemic1CTD_human
HgeneCFBC0026896Myasthenia Gravis1CTD_human
HgeneCFBC0242380Libman-Sacks Disease1CTD_human
HgeneCFBC0242383Age related macular degeneration1CTD_human;GENOMICS_ENGLAND
HgeneCFBC0272242Complement deficiency disease1GENOMICS_ENGLAND
HgeneCFBC0751339Myasthenia Gravis, Generalized1CTD_human
HgeneCFBC0751340Myasthenia Gravis, Ocular1CTD_human
HgeneCFBC3809950COMPLEMENT FACTOR B DEFICIENCY1CTD_human;GENOMICS_ENGLAND
HgeneCFBC4087273C3 glomerulopathy1GENOMICS_ENGLAND
TgeneC2752038HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 45GENOMICS_ENGLAND;UNIPROT
TgeneC2931788Atypical Hemolytic Uremic Syndrome3CTD_human;GENOMICS_ENGLAND
TgeneC0017662Glomerulonephritis, Membranoproliferative1GENOMICS_ENGLAND
TgeneC0019061Hemolytic-Uremic Syndrome1GENOMICS_ENGLAND
TgeneC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneC0026896Myasthenia Gravis1CTD_human
TgeneC0242380Libman-Sacks Disease1CTD_human
TgeneC0242383Age related macular degeneration1CTD_human;GENOMICS_ENGLAND
TgeneC0272242Complement deficiency disease1GENOMICS_ENGLAND
TgeneC0751339Myasthenia Gravis, Generalized1CTD_human
TgeneC0751340Myasthenia Gravis, Ocular1CTD_human
TgeneC3809950COMPLEMENT FACTOR B DEFICIENCY1CTD_human;GENOMICS_ENGLAND
TgeneC4087273C3 glomerulopathy1GENOMICS_ENGLAND