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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATXN2-MTAP (FusionGDB2 ID:HG6311TG4507)

Fusion Gene Summary for ATXN2-MTAP

check button Fusion gene summary
Fusion gene informationFusion gene name: ATXN2-MTAP
Fusion gene ID: hg6311tg4507
HgeneTgene
Gene symbol

ATXN2

MTAP

Gene ID

6311

4507

Gene nameataxin 2methylthioadenosine phosphorylase
SynonymsATX2|SCA2|TNRC13BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus
Cytomap('ATXN2')('MTAP')

12q24.12

9p21.3

Type of geneprotein-codingprotein-coding
Descriptionataxin-2spinocerebellar ataxia type 2 proteintrinucleotide repeat-containing gene 13 proteinS-methyl-5'-thioadenosine phosphorylase5'-methylthioadenosine phosphorylaseMTA phosphorylaseMTAPaseMeSAdo phosphorylaseepididymis luminal protein 249epididymis secretory sperm binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000377617, ENST00000550104, 
ENST00000608853, ENST00000389153, 
ENST00000549455, ENST00000535949, 
ENST00000542287, 
Fusion gene scores* DoF score22 X 21 X 8=36965 X 5 X 4=100
# samples 256
** MAII scorelog2(25/3696*10)=-3.88596475675397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATXN2 [Title/Abstract] AND MTAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATXN2(112036587)-MTAP(21859301), # samples:1
Anticipated loss of major functional domain due to fusion event.ATXN2-MTAP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN2-MTAP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN2-MTAP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN2-MTAP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTAP

GO:0006738

nicotinamide riboside catabolic process

19001417


check buttonFusion gene breakpoints across ATXN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MTAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5801ATXN2chr12

112036587

-MTAPchr9

21859301

+


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Fusion Gene ORF analysis for ATXN2-MTAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377617ENST00000427788ATXN2chr12

112036587

-MTAPchr9

21859301

+
5CDS-intronENST00000550104ENST00000427788ATXN2chr12

112036587

-MTAPchr9

21859301

+
5CDS-intronENST00000608853ENST00000427788ATXN2chr12

112036587

-MTAPchr9

21859301

+
5UTR-3CDSENST00000389153ENST00000380172ATXN2chr12

112036587

-MTAPchr9

21859301

+
5UTR-3CDSENST00000389153ENST00000460874ATXN2chr12

112036587

-MTAPchr9

21859301

+
5UTR-3CDSENST00000389153ENST00000580900ATXN2chr12

112036587

-MTAPchr9

21859301

+
5UTR-3CDSENST00000549455ENST00000380172ATXN2chr12

112036587

-MTAPchr9

21859301

+
5UTR-3CDSENST00000549455ENST00000460874ATXN2chr12

112036587

-MTAPchr9

21859301

+
5UTR-3CDSENST00000549455ENST00000580900ATXN2chr12

112036587

-MTAPchr9

21859301

+
5UTR-intronENST00000389153ENST00000427788ATXN2chr12

112036587

-MTAPchr9

21859301

+
5UTR-intronENST00000549455ENST00000427788ATXN2chr12

112036587

-MTAPchr9

21859301

+
In-frameENST00000377617ENST00000380172ATXN2chr12

112036587

-MTAPchr9

21859301

+
In-frameENST00000377617ENST00000460874ATXN2chr12

112036587

-MTAPchr9

21859301

+
In-frameENST00000377617ENST00000580900ATXN2chr12

112036587

-MTAPchr9

21859301

+
In-frameENST00000550104ENST00000380172ATXN2chr12

112036587

-MTAPchr9

21859301

+
In-frameENST00000550104ENST00000460874ATXN2chr12

112036587

-MTAPchr9

21859301

+
In-frameENST00000550104ENST00000580900ATXN2chr12

112036587

-MTAPchr9

21859301

+
In-frameENST00000608853ENST00000380172ATXN2chr12

112036587

-MTAPchr9

21859301

+
In-frameENST00000608853ENST00000460874ATXN2chr12

112036587

-MTAPchr9

21859301

+
In-frameENST00000608853ENST00000580900ATXN2chr12

112036587

-MTAPchr9

21859301

+
intron-3CDSENST00000535949ENST00000380172ATXN2chr12

112036587

-MTAPchr9

21859301

+
intron-3CDSENST00000535949ENST00000460874ATXN2chr12

112036587

-MTAPchr9

21859301

+
intron-3CDSENST00000535949ENST00000580900ATXN2chr12

112036587

-MTAPchr9

21859301

+
intron-3CDSENST00000542287ENST00000380172ATXN2chr12

112036587

-MTAPchr9

21859301

+
intron-3CDSENST00000542287ENST00000460874ATXN2chr12

112036587

-MTAPchr9

21859301

+
intron-3CDSENST00000542287ENST00000580900ATXN2chr12

112036587

-MTAPchr9

21859301

+
intron-intronENST00000535949ENST00000427788ATXN2chr12

112036587

-MTAPchr9

21859301

+
intron-intronENST00000542287ENST00000427788ATXN2chr12

112036587

-MTAPchr9

21859301

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000608853ATXN2chr12112036587-ENST00000580900MTAPchr921859301+1330567273881202
ENST00000608853ATXN2chr12112036587-ENST00000380172MTAPchr921859301+57935675660189
ENST00000608853ATXN2chr12112036587-ENST00000460874MTAPchr921859301+10355675660189
ENST00000377617ATXN2chr12112036587-ENST00000580900MTAPchr921859301+1656893892113259
ENST00000377617ATXN2chr12112036587-ENST00000380172MTAPchr921859301+6119893892113259
ENST00000377617ATXN2chr12112036587-ENST00000460874MTAPchr921859301+1361893892113259
ENST00000550104ATXN2chr12112036587-ENST00000580900MTAPchr921859301+1656893892113259
ENST00000550104ATXN2chr12112036587-ENST00000380172MTAPchr921859301+6119893892113259
ENST00000550104ATXN2chr12112036587-ENST00000460874MTAPchr921859301+1361893892113259

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000608853ENST00000580900ATXN2chr12112036587-MTAPchr921859301+0.0271062740.9728937
ENST00000608853ENST00000380172ATXN2chr12112036587-MTAPchr921859301+0.222758430.7772415
ENST00000608853ENST00000460874ATXN2chr12112036587-MTAPchr921859301+0.033764910.96623516
ENST00000377617ENST00000580900ATXN2chr12112036587-MTAPchr921859301+0.02596540.9740346
ENST00000377617ENST00000380172ATXN2chr12112036587-MTAPchr921859301+0.350734170.6492658
ENST00000377617ENST00000460874ATXN2chr12112036587-MTAPchr921859301+0.037648620.9623514
ENST00000550104ENST00000580900ATXN2chr12112036587-MTAPchr921859301+0.02596540.9740346
ENST00000550104ENST00000380172ATXN2chr12112036587-MTAPchr921859301+0.350734170.6492658
ENST00000550104ENST00000460874ATXN2chr12112036587-MTAPchr921859301+0.037648620.9623514

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Fusion Genomic Features for ATXN2-MTAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATXN2chr12112036587-MTAPchr921859301+2.86E-101
ATXN2chr12112036587-MTAPchr921859301+2.86E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATXN2-MTAP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112036587/chr9:21859301)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATXN2chr12:112036587chr9:21859301ENST00000377617-125166_1872431314.0Compositional biasNote=Poly-Gln
HgeneATXN2chr12:112036587chr9:21859301ENST00000377617-125213_2232431314.0Compositional biasNote=Poly-Ser
HgeneATXN2chr12:112036587chr9:21859301ENST00000377617-12547_1582431314.0Compositional biasNote=Pro-rich
HgeneATXN2chr12:112036587chr9:21859301ENST00000377617-12555_642431314.0Compositional biasNote=Poly-Pro
HgeneATXN2chr12:112036587chr9:21859301ENST00000550104-124166_1872431015.3333333333334Compositional biasNote=Poly-Gln
HgeneATXN2chr12:112036587chr9:21859301ENST00000550104-124213_2232431015.3333333333334Compositional biasNote=Poly-Ser
HgeneATXN2chr12:112036587chr9:21859301ENST00000550104-12447_1582431015.3333333333334Compositional biasNote=Pro-rich
HgeneATXN2chr12:112036587chr9:21859301ENST00000550104-12455_642431015.3333333333334Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATXN2chr12:112036587chr9:21859301ENST00000377617-125551_7342431314.0Compositional biasNote=Pro-rich
HgeneATXN2chr12:112036587chr9:21859301ENST00000377617-125929_10852431314.0Compositional biasNote=Pro-rich
HgeneATXN2chr12:112036587chr9:21859301ENST00000550104-124551_7342431015.3333333333334Compositional biasNote=Pro-rich
HgeneATXN2chr12:112036587chr9:21859301ENST00000550104-124929_10852431015.3333333333334Compositional biasNote=Pro-rich
TgeneMTAPchr12:112036587chr9:21859301ENST0000038017258220_222230284.0RegionNote=Substrate binding
TgeneMTAPchr12:112036587chr9:21859301ENST000003801725860_61230284.0RegionNote=Phosphate binding
TgeneMTAPchr12:112036587chr9:21859301ENST000003801725893_94230284.0RegionNote=Phosphate binding
TgeneMTAPchr12:112036587chr9:21859301ENST0000058090058220_222230335.0RegionNote=Substrate binding
TgeneMTAPchr12:112036587chr9:21859301ENST000005809005860_61230335.0RegionNote=Phosphate binding
TgeneMTAPchr12:112036587chr9:21859301ENST000005809005893_94230335.0RegionNote=Phosphate binding


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Fusion Gene Sequence for ATXN2-MTAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8429_8429_1_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000377617_MTAP_chr9_21859301_ENST00000380172_length(transcript)=6119nt_BP=893nt
ACCCCCGAGAAAGCAACCCAGCGCGCCGCCCGCTCCTCACGTGTCCCTCCCGGCCCCGGGGCCACCTCACGTTCTGCTTCCGTCTGACCC
CTCCGACTTCCGGTAAAGAGTCCCTATCCGCACCTCCGCTCCCACCCGGCGCCTCGGCGCGCCCGCCCTCCGATGCGCTCAGCGGCCGCA
GCTCCTCGGAGTCCCGCGGTGGCCACCGAGTCTCGCCGCTTCGCCGCAGCCAGGTGGCCCGGGTGGCGCTCGCTCCAGCGGCCGGCGCGG
CGGAGCGGGCGGGGCGGCGGTGGCGCGGCCCCGGGACCGTATCCCTCCGCCGCCCCTCCCCCGCCCGGCCCCGGCCCCCCTCCCTCCCGG
CAGAGCTCGCCTCCCTCCGCCTCAGACTGTTTTGGTAGCAACGGCAACGGCGGCGGCGCGTTTCGGCCCGGCTCCCGGCGGCTCCTTGGT
CTCGGCGGGCCTCCCCGCCCCTTCGTCGTCCTCCTTCTCCCCCTCGCCAGCCCGGGCGCCCCTCCGGCCGCGCCAACCCGCGCCTCCCCG
CTCGGCGCCCGCGCGTCCCCGCCGCGTTCCGGCGTCTCCTTGGCGCGCCCGGCTCCCGGCTGTCCCCGCCCGGCGTGCGAGCCGGTGTAT
GGGCCCCTCACCATGTCGCTGAAGCCCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCCGCCGCCCGCGGCTGCCAATGTCCGCAAGCCCGGCGGCAGCGGCCTTCTAGCGTCGCCCGCCGCCGCGCCTTCGCCGTCCTCG
TCCTCGGTCTCCTCGTCCTCGGCCACGGCTCCCTCCTCGGTGGTCGCGGCGACCTCCGGCGGCGGGAGGCCCGGCCTGGGCAGGTTTCGG
TGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAAT
GGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACCAAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAA
GAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATATGGGAAAGACATGCAGCTTTCATGCCCTTGCCTAT
CAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAATGATTTAGACAACTTCAAAATACAGAAGAAAAGCAA
ATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACCCACCATTCTCTTCTCCCCCTATTAAATTTGCAACA
ATAAAGGGTGGAGGGTAATCTCTACTTTCCTATACTGCCAAAGAATGTGAGGAAGAAATGGGACTCTTTGGTTATTTATTGATGCGACTG
TAAATTGGTACAGTATTTCTGGAGGGCAATTTGGTAAAATGCATCAAAAGACTTAAAAATACGGACGTACTTTGTGCTGGGAACTCTACA
TCTAGCAATTTCTCTTTAAAACCATATCAGAGATGCATACAAAGAATTATATATAAAGAAGGGTGTTTAATAATGATAGTTATAATAATA
AATAATTGAAACAATCTGAATCCCTTGCAATTGGAGGTAAATTATGTCTTAGTTATAATTAGATTGTGAATCAGCCAACTGAAAATCCTT
TTTGCATATTTCAATGTCCTAAAAAGACACGGTTGCTCTATATATGAAGTGAAAAAAGGATATGGTAGCATTTTATAGTACTAGTTTTGC
TTTAAAATGCTATGTAAATATACAAAAAAACTAGAAAGAAATATATATAACCTTGTTATTGTATTTGGGGGAGGGATACTGGGATAATTT
TTATTTTCTTTGAATCTTTCTGTGTCTTCACATTTTTCTACAGTGAATTTAATCAAATAGTAAAGTTGTTGTAAAAATAAAAGTGGATTT
AGAAAGATCCAGTTCTTGAAAACACTGTTTCTGGTAATGAAGCAGAATTTAAGTTGGTAATATTAAGGTGAATGTCATTTAAGGGAGTTA
CATCTTTATTCTGCTAAAGAAGAGGATCATTGATTTCTGTACAGTCAGAACAGTACTTGGGTTTGCAACAGCTTTCTGAGAAAAGCTAGG
TGTTTAATAGTTTAACTGAAAGTTTAACTATTTAAAAGACTAAATGCACATTTTATGGTATCTGATATTTTAAAAAGTAATGTTTGATTC
TCCTTTTTATGAGTTAAATTATTTTATACGAGTTGGTAATTTTTGCTTTTTAATAAAGTGGAAGCTTGCTTTTTTAACTCTTTTTTTATT
GTTATTTTATAGAAATGCTTTTTGTTGGCCGGGCACAGTTGCTCATCCATGTAATCCCAGCACTGTGGGAGGCCGAGACGGGTGGATCAC
AAGGTCAGGAGATCGAGACCATCCTGGCTAATGCGTTGAAACTCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGTGGGC
ACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGAGGTGGAGCTTGCAGTGAGCAGAGCTTGCAGTGAG
ACGAGCTTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCAGTCTCAAAAAAAAAAAAAAGAGTGAAATGCTTTTTGTTTGCT
TCAGTTTTTTATCATGGGGAGATCTTTTTCCTCAGAATTGTTTTCTTTTCACTGTAGGCTATTACAGGATACTTCAGGATCAAGATACAG
AACCTTTTATTTAAAGAGTTTGTAAAGTCAATGTGTTTGTTTGTGTCTCTGAGATTGACTTCAAGATAATAAGCTGCTAATTGTAAACAA
AACAGTTACCCTCCAGTATTAATATGACTCATTAGTGTGAGCCATTTGGGTCAAGTATGATTATGACCCTTGGACTTCCTGATGTAGTAT
TAAATTTCAACTCTGGTTATCCATTAGCAATCTGTAGAGAACTTAATGAACCTGAACCCAGGCTTCTCTAGCTCTGGTAACGTGTGATTG
TTTTCACTACAATATGATACATAGATGGTACCTTACTTTTCCTCATTCTTAATAGGTGTCTAAGAATGTCAGGGCAAAAGTATGGGCATT
TTTCTTGCTATGTTCAGAAAGTACAGTTCTCTCCAACTTGCAGAGGTACTTTTCTTGATTAAATAGCCTTCTCTAGCAACATCATTTTCA
GACTAACTAAATGAATGCAGTATACTCTTTTCTTTGTTCTCAATCATTCACTCCTTATGCAAAGCCAATATAATTTTCCTCATACCTTAT
GCTTGAGGATATTGTTGAAGAACACTTCCTGGAACACTTCTCACTTGTGATGCTGTACTAATTTTTTTTTTTTAATTTAAGCTAGTATAC
TAAGTGAACACCATGGTCAGTTGTGAGCATTTTGGTTTCCGCAAAGGATGGATGGTGAGCATCATGGGAAAGCTGTAGTTTAGTGACTTA
GCCCTTAGTGATTAATAGATTTGCATGTACATAGAAGTCTTTGTTGGCCTTATAATCTGCTGTTATATTTGGCATGGATTTTCATGGTTT
TGAGAATGACATCCTGGCCCTGTGGTCCCCGAGGGTCATGGTCCTTGTGACCTGGCCCCTGTTCACTGCCCCCTTCGCTAGCACGAGTTG
CTGTGCAGGGCTGGAGGTAGCTACCATGGCTTGTTTCAAGGAAGGAAACTCTGGTACGGTGGCACCCTCAGGAGTGGAGGACAGTGAACT
TCCTTGAAGAGGGAGTGACTAAGGTGACCTCCAACCTGCCCTGAGCCAGCTGCCCTGCAGGTGCCACGTGAGCCTGCTCTGGCATCCACA
GGATGCTCCTGGAGCCTCTTCTCTGGCTGCTACCTCAGGGCATGGTTGTGGCCCCACCAACACCTATTTTCCAAATAATTATTCATTCTT
GTGACAGTGGCCTGAACATGTTTTTAATTTTCTCAACAAGCATTTAGCCAGCACTTATCCAGTGAAACAATTTGATAAGGTTTCAAGGAG
TATCTGATGGGTTAGGAAGTCACGAAATGAGGAGTTCTTGCCACATTTGCAGAGTCCCTCCTTGATAAGGTTTGGCGGTGTCCCCACCCA
AATCTCATGTTGAATTGTAGTTCCCATAATCCCCACATGTTGTGGGAGGGACCCAGTGGGAGGTAATTAAATCATGGGGGTGGTTACCCC
CACACTGCTGTTCTCATGATACTGAGTTCTCACAAGTCCTGTTTGTTTTATAAGGGGCTTTTCCCCCTTTTGCTCAACACTTCTTCCTGC
CATCATGTGAAGAAGGACGTGTTTGTTTCCCCTTCTGCCACGATTGTAAGTTTCCTGAGGCCTTCCCAGCTATGTGGAACTGTGAGTTAA
TTAAACCTCTTTCCTTTATAAATTACCCAGTCATGGGCAGTCCTTTACAGCAGCATGAGAATGGACTAATACACTCCTCAAATGTTTTGA
AGATTGTTGCACCTTGGAACTACCAGTGTGCACACAATCTGGCTCAATGTATATATTGGCCCAGCAAGGCAAAGAACTGAAGTTCCAGGA
TGGAAGAACCTGTGTTCTCCTCATAATAGTATAGAATAATTCAAGATAGGCAAGAAGGACAGCAGTAAATGAAGACCATGGAAGAAAAGA
AGGAATGCCAAAGATCGAGGAAATCTACCAAGACTAGTAGGGTAGTCCAGAAGAAGCTGTTTCAGGGCCTGTTGCCAGCTATGCCTTTGA
GAACCTCGGGATCCCAAAGAATGAGGGGAATTTCTTCAGAAAGACAATCTCGGCATGCATTATTTCTTTGTTTTGAAGATTCACTCATGT
TGCATGCATCTGTAGCTTGTGCCTTTTTTATTGCCTAGTAGTATTCTGTCATATGCCTATCTTACAATTTGATTATCTATTCACCTGTTG
ATGAATGTTTGAATTTTTTCCATTTGAGGAATTTTATGAATAAAGCTGCTATAAGCATGAAATTACAAGTCTTTTTGTGAACATATTTTC
ACTTGTGCAAATGCCTATACTCCCACCAGTAATTTGTAAGAATTCTTGACAAAGCTTGGTATTGTCAGCGTTTTTAATTTTAGCCATTCT
ATTGGGTATATTTTGATATCTCGTGGTTTTGATTTGCATTTTTCTGATTAAAGATGTTGAACTTCTTTTCATGTGCTTATTGGCCATTCA
CATATTTCGTGAACTATCTGTACAAATATTTTTGTTTATTAAAAAATTAGATTGTTTTGTTTTATTATTGAATAGTAAGAATTGTTTATA
TATTCTGGATACACTCTTTTTCAGATATGTGTGTTGTGACTATTCTTAGTCTTTAGCTTGCCTTTTCATTTTCTTAATTATGTCTTTCAA
AGAACAAGTTTTTCATTTTGACGAAGCCTAGTTTATCAATTTTTTTTATGGTTGGTGCTTTTTGTGTGTTCCAAGAAATCTTTGCCTACT
CATTTAATTACCTGTGTGCCCTTGTCAAAATCATTTAATTTTGACTACTCACTTAATTACCTTGCCTACTCATTTAATTACCTGTGTGCC
CTTGTCAAAATTTACTGTTTATCTGTGAATCTGGATGATCTATTTATGTCATTTATCTATGTGTCTCTTCTTATGCCAGTACCCCACTGT
CTTGATTATTGTGGCTTTATGGTGTCTTGAAATTAAGTATTGTTAAGCTTTGCAATCTTTTCCAAGATTGTTTTGGCTATAGGTCCTTTC
TTTATAAAGTTTATATTAAGCTTCTCCATTTTTCTTTAAGAAAAAATCTGCTGGAATGGCACTGAATTTTTAGGTCGATTTGGGAAGAAT
TGACAATATTGAACCTTTCAATCGATGGACATGGTATGTTTCTGCATTTATTTGGGCCTTTTAAAATTTATCTCAGCAATATTTTGTAGT
TTTAGTGAAGAAGTCTTGTATATATCTTTTGTTAAATGTATTCCTAAATATTTTGTGGAAATGTTACTGTAAATAGTACTTTAATTTCAT

>8429_8429_1_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000377617_MTAP_chr9_21859301_ENST00000380172_length(amino acids)=259AA_BP=
MPRPGLPPPEVAATTEEGAVAEDEETEDEDGEGAAAGDARRPLPPGLRTLAAAGGGCCCCCCCCCCCCCCCCCCCCCCWGFSDMVRGPYT
GSHAGRGQPGAGRAKETPERGGDARAPSGEARVGAAGGAPGLARGRRRTTKGRGGPPRPRSRREPGRNAPPPLPLLPKQSEAEGGELCRE

--------------------------------------------------------------
>8429_8429_2_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000377617_MTAP_chr9_21859301_ENST00000460874_length(transcript)=1361nt_BP=893nt
ACCCCCGAGAAAGCAACCCAGCGCGCCGCCCGCTCCTCACGTGTCCCTCCCGGCCCCGGGGCCACCTCACGTTCTGCTTCCGTCTGACCC
CTCCGACTTCCGGTAAAGAGTCCCTATCCGCACCTCCGCTCCCACCCGGCGCCTCGGCGCGCCCGCCCTCCGATGCGCTCAGCGGCCGCA
GCTCCTCGGAGTCCCGCGGTGGCCACCGAGTCTCGCCGCTTCGCCGCAGCCAGGTGGCCCGGGTGGCGCTCGCTCCAGCGGCCGGCGCGG
CGGAGCGGGCGGGGCGGCGGTGGCGCGGCCCCGGGACCGTATCCCTCCGCCGCCCCTCCCCCGCCCGGCCCCGGCCCCCCTCCCTCCCGG
CAGAGCTCGCCTCCCTCCGCCTCAGACTGTTTTGGTAGCAACGGCAACGGCGGCGGCGCGTTTCGGCCCGGCTCCCGGCGGCTCCTTGGT
CTCGGCGGGCCTCCCCGCCCCTTCGTCGTCCTCCTTCTCCCCCTCGCCAGCCCGGGCGCCCCTCCGGCCGCGCCAACCCGCGCCTCCCCG
CTCGGCGCCCGCGCGTCCCCGCCGCGTTCCGGCGTCTCCTTGGCGCGCCCGGCTCCCGGCTGTCCCCGCCCGGCGTGCGAGCCGGTGTAT
GGGCCCCTCACCATGTCGCTGAAGCCCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCCGCCGCCCGCGGCTGCCAATGTCCGCAAGCCCGGCGGCAGCGGCCTTCTAGCGTCGCCCGCCGCCGCGCCTTCGCCGTCCTCG
TCCTCGGTCTCCTCGTCCTCGGCCACGGCTCCCTCCTCGGTGGTCGCGGCGACCTCCGGCGGCGGGAGGCCCGGCCTGGGCAGGTTTCGG
TGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAAT
GGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACCAAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAA
GAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATATGGGAAAGACATGCAGCTTTCATGCCCTTGCCTAT
CAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAATGATTTAGACAACTTCAAAATACAGAAGAAAAGCAA
ATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACCCACCATTCTCTTCTCCCCCTATTAAATTTGCAACA

>8429_8429_2_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000377617_MTAP_chr9_21859301_ENST00000460874_length(amino acids)=259AA_BP=
MPRPGLPPPEVAATTEEGAVAEDEETEDEDGEGAAAGDARRPLPPGLRTLAAAGGGCCCCCCCCCCCCCCCCCCCCCCWGFSDMVRGPYT
GSHAGRGQPGAGRAKETPERGGDARAPSGEARVGAAGGAPGLARGRRRTTKGRGGPPRPRSRREPGRNAPPPLPLLPKQSEAEGGELCRE

--------------------------------------------------------------
>8429_8429_3_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000377617_MTAP_chr9_21859301_ENST00000580900_length(transcript)=1656nt_BP=893nt
ACCCCCGAGAAAGCAACCCAGCGCGCCGCCCGCTCCTCACGTGTCCCTCCCGGCCCCGGGGCCACCTCACGTTCTGCTTCCGTCTGACCC
CTCCGACTTCCGGTAAAGAGTCCCTATCCGCACCTCCGCTCCCACCCGGCGCCTCGGCGCGCCCGCCCTCCGATGCGCTCAGCGGCCGCA
GCTCCTCGGAGTCCCGCGGTGGCCACCGAGTCTCGCCGCTTCGCCGCAGCCAGGTGGCCCGGGTGGCGCTCGCTCCAGCGGCCGGCGCGG
CGGAGCGGGCGGGGCGGCGGTGGCGCGGCCCCGGGACCGTATCCCTCCGCCGCCCCTCCCCCGCCCGGCCCCGGCCCCCCTCCCTCCCGG
CAGAGCTCGCCTCCCTCCGCCTCAGACTGTTTTGGTAGCAACGGCAACGGCGGCGGCGCGTTTCGGCCCGGCTCCCGGCGGCTCCTTGGT
CTCGGCGGGCCTCCCCGCCCCTTCGTCGTCCTCCTTCTCCCCCTCGCCAGCCCGGGCGCCCCTCCGGCCGCGCCAACCCGCGCCTCCCCG
CTCGGCGCCCGCGCGTCCCCGCCGCGTTCCGGCGTCTCCTTGGCGCGCCCGGCTCCCGGCTGTCCCCGCCCGGCGTGCGAGCCGGTGTAT
GGGCCCCTCACCATGTCGCTGAAGCCCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCCGCCGCCCGCGGCTGCCAATGTCCGCAAGCCCGGCGGCAGCGGCCTTCTAGCGTCGCCCGCCGCCGCGCCTTCGCCGTCCTCG
TCCTCGGTCTCCTCGTCCTCGGCCACGGCTCCCTCCTCGGTGGTCGCGGCGACCTCCGGCGGCGGGAGGCCCGGCCTGGGCAGGTTTCGG
TGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAAT
GGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTGAGGGATACCATCCTTTCAATATTCAAGAGTCACCCT
TCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCCTGCCCCTGTCTCCCTTAGACCTGGCTGGATACTGCT
TCCAACAACCCATGCAGCCACCCTGCCCTGACAGCTAGCAAGAGGCCAAGACCCACAGAACAATCACCATCACACCTCTGTCAGCAGGAA
GCAGTTACAGAAGACTGACCTTCATCCAGTTTCCCAAAGAATTGGGTCATGGATTTTTGCGGGGGAAAATGTTAGAGTAGGTAATTAGGC
AGACATGAGTAAGGGAGGAGAGACCCCCTCCAACTAGGAATGTCAGGTGAGCATCAGATGATCATCAGGTGGTTGTTAAACTCTCTCTCT
AAAATAATAATAGGTTGCAACTGGCAGCAGGGAAAGACAATCTCCCAATAGATAGAAAAGTCCTGAAGCTGGTGATCAGCAGCTTCCTAG
TAAGATCTCAGGATTTGGGCAAGCAGGCTCAAACATGGGCACTAAGAGGCAAAATCGTGGAGTTTAACTGGTATACAGACTTCCTCTAAA

>8429_8429_3_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000377617_MTAP_chr9_21859301_ENST00000580900_length(amino acids)=259AA_BP=
MPRPGLPPPEVAATTEEGAVAEDEETEDEDGEGAAAGDARRPLPPGLRTLAAAGGGCCCCCCCCCCCCCCCCCCCCCCWGFSDMVRGPYT
GSHAGRGQPGAGRAKETPERGGDARAPSGEARVGAAGGAPGLARGRRRTTKGRGGPPRPRSRREPGRNAPPPLPLLPKQSEAEGGELCRE

--------------------------------------------------------------
>8429_8429_4_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000550104_MTAP_chr9_21859301_ENST00000380172_length(transcript)=6119nt_BP=893nt
ACCCCCGAGAAAGCAACCCAGCGCGCCGCCCGCTCCTCACGTGTCCCTCCCGGCCCCGGGGCCACCTCACGTTCTGCTTCCGTCTGACCC
CTCCGACTTCCGGTAAAGAGTCCCTATCCGCACCTCCGCTCCCACCCGGCGCCTCGGCGCGCCCGCCCTCCGATGCGCTCAGCGGCCGCA
GCTCCTCGGAGTCCCGCGGTGGCCACCGAGTCTCGCCGCTTCGCCGCAGCCAGGTGGCCCGGGTGGCGCTCGCTCCAGCGGCCGGCGCGG
CGGAGCGGGCGGGGCGGCGGTGGCGCGGCCCCGGGACCGTATCCCTCCGCCGCCCCTCCCCCGCCCGGCCCCGGCCCCCCTCCCTCCCGG
CAGAGCTCGCCTCCCTCCGCCTCAGACTGTTTTGGTAGCAACGGCAACGGCGGCGGCGCGTTTCGGCCCGGCTCCCGGCGGCTCCTTGGT
CTCGGCGGGCCTCCCCGCCCCTTCGTCGTCCTCCTTCTCCCCCTCGCCAGCCCGGGCGCCCCTCCGGCCGCGCCAACCCGCGCCTCCCCG
CTCGGCGCCCGCGCGTCCCCGCCGCGTTCCGGCGTCTCCTTGGCGCGCCCGGCTCCCGGCTGTCCCCGCCCGGCGTGCGAGCCGGTGTAT
GGGCCCCTCACCATGTCGCTGAAGCCCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCCGCCGCCCGCGGCTGCCAATGTCCGCAAGCCCGGCGGCAGCGGCCTTCTAGCGTCGCCCGCCGCCGCGCCTTCGCCGTCCTCG
TCCTCGGTCTCCTCGTCCTCGGCCACGGCTCCCTCCTCGGTGGTCGCGGCGACCTCCGGCGGCGGGAGGCCCGGCCTGGGCAGGTTTCGG
TGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAAT
GGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACCAAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAA
GAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATATGGGAAAGACATGCAGCTTTCATGCCCTTGCCTAT
CAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAATGATTTAGACAACTTCAAAATACAGAAGAAAAGCAA
ATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACCCACCATTCTCTTCTCCCCCTATTAAATTTGCAACA
ATAAAGGGTGGAGGGTAATCTCTACTTTCCTATACTGCCAAAGAATGTGAGGAAGAAATGGGACTCTTTGGTTATTTATTGATGCGACTG
TAAATTGGTACAGTATTTCTGGAGGGCAATTTGGTAAAATGCATCAAAAGACTTAAAAATACGGACGTACTTTGTGCTGGGAACTCTACA
TCTAGCAATTTCTCTTTAAAACCATATCAGAGATGCATACAAAGAATTATATATAAAGAAGGGTGTTTAATAATGATAGTTATAATAATA
AATAATTGAAACAATCTGAATCCCTTGCAATTGGAGGTAAATTATGTCTTAGTTATAATTAGATTGTGAATCAGCCAACTGAAAATCCTT
TTTGCATATTTCAATGTCCTAAAAAGACACGGTTGCTCTATATATGAAGTGAAAAAAGGATATGGTAGCATTTTATAGTACTAGTTTTGC
TTTAAAATGCTATGTAAATATACAAAAAAACTAGAAAGAAATATATATAACCTTGTTATTGTATTTGGGGGAGGGATACTGGGATAATTT
TTATTTTCTTTGAATCTTTCTGTGTCTTCACATTTTTCTACAGTGAATTTAATCAAATAGTAAAGTTGTTGTAAAAATAAAAGTGGATTT
AGAAAGATCCAGTTCTTGAAAACACTGTTTCTGGTAATGAAGCAGAATTTAAGTTGGTAATATTAAGGTGAATGTCATTTAAGGGAGTTA
CATCTTTATTCTGCTAAAGAAGAGGATCATTGATTTCTGTACAGTCAGAACAGTACTTGGGTTTGCAACAGCTTTCTGAGAAAAGCTAGG
TGTTTAATAGTTTAACTGAAAGTTTAACTATTTAAAAGACTAAATGCACATTTTATGGTATCTGATATTTTAAAAAGTAATGTTTGATTC
TCCTTTTTATGAGTTAAATTATTTTATACGAGTTGGTAATTTTTGCTTTTTAATAAAGTGGAAGCTTGCTTTTTTAACTCTTTTTTTATT
GTTATTTTATAGAAATGCTTTTTGTTGGCCGGGCACAGTTGCTCATCCATGTAATCCCAGCACTGTGGGAGGCCGAGACGGGTGGATCAC
AAGGTCAGGAGATCGAGACCATCCTGGCTAATGCGTTGAAACTCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGTGGGC
ACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGAGGTGGAGCTTGCAGTGAGCAGAGCTTGCAGTGAG
ACGAGCTTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCAGTCTCAAAAAAAAAAAAAAGAGTGAAATGCTTTTTGTTTGCT
TCAGTTTTTTATCATGGGGAGATCTTTTTCCTCAGAATTGTTTTCTTTTCACTGTAGGCTATTACAGGATACTTCAGGATCAAGATACAG
AACCTTTTATTTAAAGAGTTTGTAAAGTCAATGTGTTTGTTTGTGTCTCTGAGATTGACTTCAAGATAATAAGCTGCTAATTGTAAACAA
AACAGTTACCCTCCAGTATTAATATGACTCATTAGTGTGAGCCATTTGGGTCAAGTATGATTATGACCCTTGGACTTCCTGATGTAGTAT
TAAATTTCAACTCTGGTTATCCATTAGCAATCTGTAGAGAACTTAATGAACCTGAACCCAGGCTTCTCTAGCTCTGGTAACGTGTGATTG
TTTTCACTACAATATGATACATAGATGGTACCTTACTTTTCCTCATTCTTAATAGGTGTCTAAGAATGTCAGGGCAAAAGTATGGGCATT
TTTCTTGCTATGTTCAGAAAGTACAGTTCTCTCCAACTTGCAGAGGTACTTTTCTTGATTAAATAGCCTTCTCTAGCAACATCATTTTCA
GACTAACTAAATGAATGCAGTATACTCTTTTCTTTGTTCTCAATCATTCACTCCTTATGCAAAGCCAATATAATTTTCCTCATACCTTAT
GCTTGAGGATATTGTTGAAGAACACTTCCTGGAACACTTCTCACTTGTGATGCTGTACTAATTTTTTTTTTTTAATTTAAGCTAGTATAC
TAAGTGAACACCATGGTCAGTTGTGAGCATTTTGGTTTCCGCAAAGGATGGATGGTGAGCATCATGGGAAAGCTGTAGTTTAGTGACTTA
GCCCTTAGTGATTAATAGATTTGCATGTACATAGAAGTCTTTGTTGGCCTTATAATCTGCTGTTATATTTGGCATGGATTTTCATGGTTT
TGAGAATGACATCCTGGCCCTGTGGTCCCCGAGGGTCATGGTCCTTGTGACCTGGCCCCTGTTCACTGCCCCCTTCGCTAGCACGAGTTG
CTGTGCAGGGCTGGAGGTAGCTACCATGGCTTGTTTCAAGGAAGGAAACTCTGGTACGGTGGCACCCTCAGGAGTGGAGGACAGTGAACT
TCCTTGAAGAGGGAGTGACTAAGGTGACCTCCAACCTGCCCTGAGCCAGCTGCCCTGCAGGTGCCACGTGAGCCTGCTCTGGCATCCACA
GGATGCTCCTGGAGCCTCTTCTCTGGCTGCTACCTCAGGGCATGGTTGTGGCCCCACCAACACCTATTTTCCAAATAATTATTCATTCTT
GTGACAGTGGCCTGAACATGTTTTTAATTTTCTCAACAAGCATTTAGCCAGCACTTATCCAGTGAAACAATTTGATAAGGTTTCAAGGAG
TATCTGATGGGTTAGGAAGTCACGAAATGAGGAGTTCTTGCCACATTTGCAGAGTCCCTCCTTGATAAGGTTTGGCGGTGTCCCCACCCA
AATCTCATGTTGAATTGTAGTTCCCATAATCCCCACATGTTGTGGGAGGGACCCAGTGGGAGGTAATTAAATCATGGGGGTGGTTACCCC
CACACTGCTGTTCTCATGATACTGAGTTCTCACAAGTCCTGTTTGTTTTATAAGGGGCTTTTCCCCCTTTTGCTCAACACTTCTTCCTGC
CATCATGTGAAGAAGGACGTGTTTGTTTCCCCTTCTGCCACGATTGTAAGTTTCCTGAGGCCTTCCCAGCTATGTGGAACTGTGAGTTAA
TTAAACCTCTTTCCTTTATAAATTACCCAGTCATGGGCAGTCCTTTACAGCAGCATGAGAATGGACTAATACACTCCTCAAATGTTTTGA
AGATTGTTGCACCTTGGAACTACCAGTGTGCACACAATCTGGCTCAATGTATATATTGGCCCAGCAAGGCAAAGAACTGAAGTTCCAGGA
TGGAAGAACCTGTGTTCTCCTCATAATAGTATAGAATAATTCAAGATAGGCAAGAAGGACAGCAGTAAATGAAGACCATGGAAGAAAAGA
AGGAATGCCAAAGATCGAGGAAATCTACCAAGACTAGTAGGGTAGTCCAGAAGAAGCTGTTTCAGGGCCTGTTGCCAGCTATGCCTTTGA
GAACCTCGGGATCCCAAAGAATGAGGGGAATTTCTTCAGAAAGACAATCTCGGCATGCATTATTTCTTTGTTTTGAAGATTCACTCATGT
TGCATGCATCTGTAGCTTGTGCCTTTTTTATTGCCTAGTAGTATTCTGTCATATGCCTATCTTACAATTTGATTATCTATTCACCTGTTG
ATGAATGTTTGAATTTTTTCCATTTGAGGAATTTTATGAATAAAGCTGCTATAAGCATGAAATTACAAGTCTTTTTGTGAACATATTTTC
ACTTGTGCAAATGCCTATACTCCCACCAGTAATTTGTAAGAATTCTTGACAAAGCTTGGTATTGTCAGCGTTTTTAATTTTAGCCATTCT
ATTGGGTATATTTTGATATCTCGTGGTTTTGATTTGCATTTTTCTGATTAAAGATGTTGAACTTCTTTTCATGTGCTTATTGGCCATTCA
CATATTTCGTGAACTATCTGTACAAATATTTTTGTTTATTAAAAAATTAGATTGTTTTGTTTTATTATTGAATAGTAAGAATTGTTTATA
TATTCTGGATACACTCTTTTTCAGATATGTGTGTTGTGACTATTCTTAGTCTTTAGCTTGCCTTTTCATTTTCTTAATTATGTCTTTCAA
AGAACAAGTTTTTCATTTTGACGAAGCCTAGTTTATCAATTTTTTTTATGGTTGGTGCTTTTTGTGTGTTCCAAGAAATCTTTGCCTACT
CATTTAATTACCTGTGTGCCCTTGTCAAAATCATTTAATTTTGACTACTCACTTAATTACCTTGCCTACTCATTTAATTACCTGTGTGCC
CTTGTCAAAATTTACTGTTTATCTGTGAATCTGGATGATCTATTTATGTCATTTATCTATGTGTCTCTTCTTATGCCAGTACCCCACTGT
CTTGATTATTGTGGCTTTATGGTGTCTTGAAATTAAGTATTGTTAAGCTTTGCAATCTTTTCCAAGATTGTTTTGGCTATAGGTCCTTTC
TTTATAAAGTTTATATTAAGCTTCTCCATTTTTCTTTAAGAAAAAATCTGCTGGAATGGCACTGAATTTTTAGGTCGATTTGGGAAGAAT
TGACAATATTGAACCTTTCAATCGATGGACATGGTATGTTTCTGCATTTATTTGGGCCTTTTAAAATTTATCTCAGCAATATTTTGTAGT
TTTAGTGAAGAAGTCTTGTATATATCTTTTGTTAAATGTATTCCTAAATATTTTGTGGAAATGTTACTGTAAATAGTACTTTAATTTCAT

>8429_8429_4_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000550104_MTAP_chr9_21859301_ENST00000380172_length(amino acids)=259AA_BP=
MPRPGLPPPEVAATTEEGAVAEDEETEDEDGEGAAAGDARRPLPPGLRTLAAAGGGCCCCCCCCCCCCCCCCCCCCCCWGFSDMVRGPYT
GSHAGRGQPGAGRAKETPERGGDARAPSGEARVGAAGGAPGLARGRRRTTKGRGGPPRPRSRREPGRNAPPPLPLLPKQSEAEGGELCRE

--------------------------------------------------------------
>8429_8429_5_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000550104_MTAP_chr9_21859301_ENST00000460874_length(transcript)=1361nt_BP=893nt
ACCCCCGAGAAAGCAACCCAGCGCGCCGCCCGCTCCTCACGTGTCCCTCCCGGCCCCGGGGCCACCTCACGTTCTGCTTCCGTCTGACCC
CTCCGACTTCCGGTAAAGAGTCCCTATCCGCACCTCCGCTCCCACCCGGCGCCTCGGCGCGCCCGCCCTCCGATGCGCTCAGCGGCCGCA
GCTCCTCGGAGTCCCGCGGTGGCCACCGAGTCTCGCCGCTTCGCCGCAGCCAGGTGGCCCGGGTGGCGCTCGCTCCAGCGGCCGGCGCGG
CGGAGCGGGCGGGGCGGCGGTGGCGCGGCCCCGGGACCGTATCCCTCCGCCGCCCCTCCCCCGCCCGGCCCCGGCCCCCCTCCCTCCCGG
CAGAGCTCGCCTCCCTCCGCCTCAGACTGTTTTGGTAGCAACGGCAACGGCGGCGGCGCGTTTCGGCCCGGCTCCCGGCGGCTCCTTGGT
CTCGGCGGGCCTCCCCGCCCCTTCGTCGTCCTCCTTCTCCCCCTCGCCAGCCCGGGCGCCCCTCCGGCCGCGCCAACCCGCGCCTCCCCG
CTCGGCGCCCGCGCGTCCCCGCCGCGTTCCGGCGTCTCCTTGGCGCGCCCGGCTCCCGGCTGTCCCCGCCCGGCGTGCGAGCCGGTGTAT
GGGCCCCTCACCATGTCGCTGAAGCCCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCCGCCGCCCGCGGCTGCCAATGTCCGCAAGCCCGGCGGCAGCGGCCTTCTAGCGTCGCCCGCCGCCGCGCCTTCGCCGTCCTCG
TCCTCGGTCTCCTCGTCCTCGGCCACGGCTCCCTCCTCGGTGGTCGCGGCGACCTCCGGCGGCGGGAGGCCCGGCCTGGGCAGGTTTCGG
TGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAAT
GGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACCAAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAA
GAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATATGGGAAAGACATGCAGCTTTCATGCCCTTGCCTAT
CAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAATGATTTAGACAACTTCAAAATACAGAAGAAAAGCAA
ATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACCCACCATTCTCTTCTCCCCCTATTAAATTTGCAACA

>8429_8429_5_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000550104_MTAP_chr9_21859301_ENST00000460874_length(amino acids)=259AA_BP=
MPRPGLPPPEVAATTEEGAVAEDEETEDEDGEGAAAGDARRPLPPGLRTLAAAGGGCCCCCCCCCCCCCCCCCCCCCCWGFSDMVRGPYT
GSHAGRGQPGAGRAKETPERGGDARAPSGEARVGAAGGAPGLARGRRRTTKGRGGPPRPRSRREPGRNAPPPLPLLPKQSEAEGGELCRE

--------------------------------------------------------------
>8429_8429_6_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000550104_MTAP_chr9_21859301_ENST00000580900_length(transcript)=1656nt_BP=893nt
ACCCCCGAGAAAGCAACCCAGCGCGCCGCCCGCTCCTCACGTGTCCCTCCCGGCCCCGGGGCCACCTCACGTTCTGCTTCCGTCTGACCC
CTCCGACTTCCGGTAAAGAGTCCCTATCCGCACCTCCGCTCCCACCCGGCGCCTCGGCGCGCCCGCCCTCCGATGCGCTCAGCGGCCGCA
GCTCCTCGGAGTCCCGCGGTGGCCACCGAGTCTCGCCGCTTCGCCGCAGCCAGGTGGCCCGGGTGGCGCTCGCTCCAGCGGCCGGCGCGG
CGGAGCGGGCGGGGCGGCGGTGGCGCGGCCCCGGGACCGTATCCCTCCGCCGCCCCTCCCCCGCCCGGCCCCGGCCCCCCTCCCTCCCGG
CAGAGCTCGCCTCCCTCCGCCTCAGACTGTTTTGGTAGCAACGGCAACGGCGGCGGCGCGTTTCGGCCCGGCTCCCGGCGGCTCCTTGGT
CTCGGCGGGCCTCCCCGCCCCTTCGTCGTCCTCCTTCTCCCCCTCGCCAGCCCGGGCGCCCCTCCGGCCGCGCCAACCCGCGCCTCCCCG
CTCGGCGCCCGCGCGTCCCCGCCGCGTTCCGGCGTCTCCTTGGCGCGCCCGGCTCCCGGCTGTCCCCGCCCGGCGTGCGAGCCGGTGTAT
GGGCCCCTCACCATGTCGCTGAAGCCCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCCGCCGCCCGCGGCTGCCAATGTCCGCAAGCCCGGCGGCAGCGGCCTTCTAGCGTCGCCCGCCGCCGCGCCTTCGCCGTCCTCG
TCCTCGGTCTCCTCGTCCTCGGCCACGGCTCCCTCCTCGGTGGTCGCGGCGACCTCCGGCGGCGGGAGGCCCGGCCTGGGCAGGTTTCGG
TGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAAT
GGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTGAGGGATACCATCCTTTCAATATTCAAGAGTCACCCT
TCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCCTGCCCCTGTCTCCCTTAGACCTGGCTGGATACTGCT
TCCAACAACCCATGCAGCCACCCTGCCCTGACAGCTAGCAAGAGGCCAAGACCCACAGAACAATCACCATCACACCTCTGTCAGCAGGAA
GCAGTTACAGAAGACTGACCTTCATCCAGTTTCCCAAAGAATTGGGTCATGGATTTTTGCGGGGGAAAATGTTAGAGTAGGTAATTAGGC
AGACATGAGTAAGGGAGGAGAGACCCCCTCCAACTAGGAATGTCAGGTGAGCATCAGATGATCATCAGGTGGTTGTTAAACTCTCTCTCT
AAAATAATAATAGGTTGCAACTGGCAGCAGGGAAAGACAATCTCCCAATAGATAGAAAAGTCCTGAAGCTGGTGATCAGCAGCTTCCTAG
TAAGATCTCAGGATTTGGGCAAGCAGGCTCAAACATGGGCACTAAGAGGCAAAATCGTGGAGTTTAACTGGTATACAGACTTCCTCTAAA

>8429_8429_6_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000550104_MTAP_chr9_21859301_ENST00000580900_length(amino acids)=259AA_BP=
MPRPGLPPPEVAATTEEGAVAEDEETEDEDGEGAAAGDARRPLPPGLRTLAAAGGGCCCCCCCCCCCCCCCCCCCCCCWGFSDMVRGPYT
GSHAGRGQPGAGRAKETPERGGDARAPSGEARVGAAGGAPGLARGRRRTTKGRGGPPRPRSRREPGRNAPPPLPLLPKQSEAEGGELCRE

--------------------------------------------------------------
>8429_8429_7_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000608853_MTAP_chr9_21859301_ENST00000380172_length(transcript)=5793nt_BP=567nt
TCCCCCGCCCGGCCCCGGCCCCCCTCCCTCCCGGCAGAGCTCGCCTCCCTCCGCCTCAGACTGTTTTGGTAGCAACGGCAACGGCGGCGG
CGCGTTTCGGCCCGGCTCCCGGCGGCTCCTTGGTCTCGGCGGGCCTCCCCGCCCCTTCGTCGTCCTCCTTCTCCCCCTCGCCAGCCCGGG
CGCCCCTCCGGCCGCGCCAACCCGCGCCTCCCCGCTCGGCGCCCGCGCGTCCCCGCCGCGTTCCGGCGTCTCCTTGGCGCGCCCGGCTCC
CGGCTGTCCCCGCCCGGCGTGCGAGCCGGTGTATGGGCCCCTCACCATGTCGCTGAAGCCCCAGCAGCAGCAGCAGCAGCAGCAGCAGCA
GCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCCGCCGCCCGCGGCTGCCAATGTCCGCAAGCCCGGCGGCAGCGGCCTTCT
AGCGTCGCCCGCCGCCGCGCCTTCGCCGTCCTCGTCCTCGGTCTCCTCGTCCTCGGCCACGGCTCCCTCCTCGGTGGTCGCGGCGACCTC
CGGCGGCGGGAGGCCCGGCCTGGGCAGGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTG
CTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACCA
AGACATTAAAGTAGCATGGCTGCCCAGGAGAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATAT
GGGAAAGACATGCAGCTTTCATGCCCTTGCCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAATG
ATTTAGACAACTTCAAAATACAGAAGAAAAGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACCC
ACCATTCTCTTCTCCCCCTATTAAATTTGCAACAATAAAGGGTGGAGGGTAATCTCTACTTTCCTATACTGCCAAAGAATGTGAGGAAGA
AATGGGACTCTTTGGTTATTTATTGATGCGACTGTAAATTGGTACAGTATTTCTGGAGGGCAATTTGGTAAAATGCATCAAAAGACTTAA
AAATACGGACGTACTTTGTGCTGGGAACTCTACATCTAGCAATTTCTCTTTAAAACCATATCAGAGATGCATACAAAGAATTATATATAA
AGAAGGGTGTTTAATAATGATAGTTATAATAATAAATAATTGAAACAATCTGAATCCCTTGCAATTGGAGGTAAATTATGTCTTAGTTAT
AATTAGATTGTGAATCAGCCAACTGAAAATCCTTTTTGCATATTTCAATGTCCTAAAAAGACACGGTTGCTCTATATATGAAGTGAAAAA
AGGATATGGTAGCATTTTATAGTACTAGTTTTGCTTTAAAATGCTATGTAAATATACAAAAAAACTAGAAAGAAATATATATAACCTTGT
TATTGTATTTGGGGGAGGGATACTGGGATAATTTTTATTTTCTTTGAATCTTTCTGTGTCTTCACATTTTTCTACAGTGAATTTAATCAA
ATAGTAAAGTTGTTGTAAAAATAAAAGTGGATTTAGAAAGATCCAGTTCTTGAAAACACTGTTTCTGGTAATGAAGCAGAATTTAAGTTG
GTAATATTAAGGTGAATGTCATTTAAGGGAGTTACATCTTTATTCTGCTAAAGAAGAGGATCATTGATTTCTGTACAGTCAGAACAGTAC
TTGGGTTTGCAACAGCTTTCTGAGAAAAGCTAGGTGTTTAATAGTTTAACTGAAAGTTTAACTATTTAAAAGACTAAATGCACATTTTAT
GGTATCTGATATTTTAAAAAGTAATGTTTGATTCTCCTTTTTATGAGTTAAATTATTTTATACGAGTTGGTAATTTTTGCTTTTTAATAA
AGTGGAAGCTTGCTTTTTTAACTCTTTTTTTATTGTTATTTTATAGAAATGCTTTTTGTTGGCCGGGCACAGTTGCTCATCCATGTAATC
CCAGCACTGTGGGAGGCCGAGACGGGTGGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAATGCGTTGAAACTCCGTCTCTACTAA
AAATACAAAAAATTAGCTGGGCGTGGTGGTGGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGA
GGTGGAGCTTGCAGTGAGCAGAGCTTGCAGTGAGACGAGCTTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCAGTCTCAAA
AAAAAAAAAAAGAGTGAAATGCTTTTTGTTTGCTTCAGTTTTTTATCATGGGGAGATCTTTTTCCTCAGAATTGTTTTCTTTTCACTGTA
GGCTATTACAGGATACTTCAGGATCAAGATACAGAACCTTTTATTTAAAGAGTTTGTAAAGTCAATGTGTTTGTTTGTGTCTCTGAGATT
GACTTCAAGATAATAAGCTGCTAATTGTAAACAAAACAGTTACCCTCCAGTATTAATATGACTCATTAGTGTGAGCCATTTGGGTCAAGT
ATGATTATGACCCTTGGACTTCCTGATGTAGTATTAAATTTCAACTCTGGTTATCCATTAGCAATCTGTAGAGAACTTAATGAACCTGAA
CCCAGGCTTCTCTAGCTCTGGTAACGTGTGATTGTTTTCACTACAATATGATACATAGATGGTACCTTACTTTTCCTCATTCTTAATAGG
TGTCTAAGAATGTCAGGGCAAAAGTATGGGCATTTTTCTTGCTATGTTCAGAAAGTACAGTTCTCTCCAACTTGCAGAGGTACTTTTCTT
GATTAAATAGCCTTCTCTAGCAACATCATTTTCAGACTAACTAAATGAATGCAGTATACTCTTTTCTTTGTTCTCAATCATTCACTCCTT
ATGCAAAGCCAATATAATTTTCCTCATACCTTATGCTTGAGGATATTGTTGAAGAACACTTCCTGGAACACTTCTCACTTGTGATGCTGT
ACTAATTTTTTTTTTTTAATTTAAGCTAGTATACTAAGTGAACACCATGGTCAGTTGTGAGCATTTTGGTTTCCGCAAAGGATGGATGGT
GAGCATCATGGGAAAGCTGTAGTTTAGTGACTTAGCCCTTAGTGATTAATAGATTTGCATGTACATAGAAGTCTTTGTTGGCCTTATAAT
CTGCTGTTATATTTGGCATGGATTTTCATGGTTTTGAGAATGACATCCTGGCCCTGTGGTCCCCGAGGGTCATGGTCCTTGTGACCTGGC
CCCTGTTCACTGCCCCCTTCGCTAGCACGAGTTGCTGTGCAGGGCTGGAGGTAGCTACCATGGCTTGTTTCAAGGAAGGAAACTCTGGTA
CGGTGGCACCCTCAGGAGTGGAGGACAGTGAACTTCCTTGAAGAGGGAGTGACTAAGGTGACCTCCAACCTGCCCTGAGCCAGCTGCCCT
GCAGGTGCCACGTGAGCCTGCTCTGGCATCCACAGGATGCTCCTGGAGCCTCTTCTCTGGCTGCTACCTCAGGGCATGGTTGTGGCCCCA
CCAACACCTATTTTCCAAATAATTATTCATTCTTGTGACAGTGGCCTGAACATGTTTTTAATTTTCTCAACAAGCATTTAGCCAGCACTT
ATCCAGTGAAACAATTTGATAAGGTTTCAAGGAGTATCTGATGGGTTAGGAAGTCACGAAATGAGGAGTTCTTGCCACATTTGCAGAGTC
CCTCCTTGATAAGGTTTGGCGGTGTCCCCACCCAAATCTCATGTTGAATTGTAGTTCCCATAATCCCCACATGTTGTGGGAGGGACCCAG
TGGGAGGTAATTAAATCATGGGGGTGGTTACCCCCACACTGCTGTTCTCATGATACTGAGTTCTCACAAGTCCTGTTTGTTTTATAAGGG
GCTTTTCCCCCTTTTGCTCAACACTTCTTCCTGCCATCATGTGAAGAAGGACGTGTTTGTTTCCCCTTCTGCCACGATTGTAAGTTTCCT
GAGGCCTTCCCAGCTATGTGGAACTGTGAGTTAATTAAACCTCTTTCCTTTATAAATTACCCAGTCATGGGCAGTCCTTTACAGCAGCAT
GAGAATGGACTAATACACTCCTCAAATGTTTTGAAGATTGTTGCACCTTGGAACTACCAGTGTGCACACAATCTGGCTCAATGTATATAT
TGGCCCAGCAAGGCAAAGAACTGAAGTTCCAGGATGGAAGAACCTGTGTTCTCCTCATAATAGTATAGAATAATTCAAGATAGGCAAGAA
GGACAGCAGTAAATGAAGACCATGGAAGAAAAGAAGGAATGCCAAAGATCGAGGAAATCTACCAAGACTAGTAGGGTAGTCCAGAAGAAG
CTGTTTCAGGGCCTGTTGCCAGCTATGCCTTTGAGAACCTCGGGATCCCAAAGAATGAGGGGAATTTCTTCAGAAAGACAATCTCGGCAT
GCATTATTTCTTTGTTTTGAAGATTCACTCATGTTGCATGCATCTGTAGCTTGTGCCTTTTTTATTGCCTAGTAGTATTCTGTCATATGC
CTATCTTACAATTTGATTATCTATTCACCTGTTGATGAATGTTTGAATTTTTTCCATTTGAGGAATTTTATGAATAAAGCTGCTATAAGC
ATGAAATTACAAGTCTTTTTGTGAACATATTTTCACTTGTGCAAATGCCTATACTCCCACCAGTAATTTGTAAGAATTCTTGACAAAGCT
TGGTATTGTCAGCGTTTTTAATTTTAGCCATTCTATTGGGTATATTTTGATATCTCGTGGTTTTGATTTGCATTTTTCTGATTAAAGATG
TTGAACTTCTTTTCATGTGCTTATTGGCCATTCACATATTTCGTGAACTATCTGTACAAATATTTTTGTTTATTAAAAAATTAGATTGTT
TTGTTTTATTATTGAATAGTAAGAATTGTTTATATATTCTGGATACACTCTTTTTCAGATATGTGTGTTGTGACTATTCTTAGTCTTTAG
CTTGCCTTTTCATTTTCTTAATTATGTCTTTCAAAGAACAAGTTTTTCATTTTGACGAAGCCTAGTTTATCAATTTTTTTTATGGTTGGT
GCTTTTTGTGTGTTCCAAGAAATCTTTGCCTACTCATTTAATTACCTGTGTGCCCTTGTCAAAATCATTTAATTTTGACTACTCACTTAA
TTACCTTGCCTACTCATTTAATTACCTGTGTGCCCTTGTCAAAATTTACTGTTTATCTGTGAATCTGGATGATCTATTTATGTCATTTAT
CTATGTGTCTCTTCTTATGCCAGTACCCCACTGTCTTGATTATTGTGGCTTTATGGTGTCTTGAAATTAAGTATTGTTAAGCTTTGCAAT
CTTTTCCAAGATTGTTTTGGCTATAGGTCCTTTCTTTATAAAGTTTATATTAAGCTTCTCCATTTTTCTTTAAGAAAAAATCTGCTGGAA
TGGCACTGAATTTTTAGGTCGATTTGGGAAGAATTGACAATATTGAACCTTTCAATCGATGGACATGGTATGTTTCTGCATTTATTTGGG
CCTTTTAAAATTTATCTCAGCAATATTTTGTAGTTTTAGTGAAGAAGTCTTGTATATATCTTTTGTTAAATGTATTCCTAAATATTTTGT
GGAAATGTTACTGTAAATAGTACTTTAATTTCATTTTTAAGTTTATTGCTGGTATACAGAAATATGTTTTATTTTTGTATATTGACTTTA

>8429_8429_7_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000608853_MTAP_chr9_21859301_ENST00000380172_length(amino acids)=189AA_BP=
MPRPGLPPPEVAATTEEGAVAEDEETEDEDGEGAAAGDARRPLPPGLRTLAAAGGGCCCCCCCCCCCCCCCCCCCCCCWGFSDMVRGPYT
GSHAGRGQPGAGRAKETPERGGDARAPSGEARVGAAGGAPGLARGRRRTTKGRGGPPRPRSRREPGRNAPPPLPLLPKQSEAEGGELCRE

--------------------------------------------------------------
>8429_8429_8_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000608853_MTAP_chr9_21859301_ENST00000460874_length(transcript)=1035nt_BP=567nt
TCCCCCGCCCGGCCCCGGCCCCCCTCCCTCCCGGCAGAGCTCGCCTCCCTCCGCCTCAGACTGTTTTGGTAGCAACGGCAACGGCGGCGG
CGCGTTTCGGCCCGGCTCCCGGCGGCTCCTTGGTCTCGGCGGGCCTCCCCGCCCCTTCGTCGTCCTCCTTCTCCCCCTCGCCAGCCCGGG
CGCCCCTCCGGCCGCGCCAACCCGCGCCTCCCCGCTCGGCGCCCGCGCGTCCCCGCCGCGTTCCGGCGTCTCCTTGGCGCGCCCGGCTCC
CGGCTGTCCCCGCCCGGCGTGCGAGCCGGTGTATGGGCCCCTCACCATGTCGCTGAAGCCCCAGCAGCAGCAGCAGCAGCAGCAGCAGCA
GCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCCGCCGCCCGCGGCTGCCAATGTCCGCAAGCCCGGCGGCAGCGGCCTTCT
AGCGTCGCCCGCCGCCGCGCCTTCGCCGTCCTCGTCCTCGGTCTCCTCGTCCTCGGCCACGGCTCCCTCCTCGGTGGTCGCGGCGACCTC
CGGCGGCGGGAGGCCCGGCCTGGGCAGGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTG
CTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACCA
AGACATTAAAGTAGCATGGCTGCCCAGGAGAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATAT
GGGAAAGACATGCAGCTTTCATGCCCTTGCCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAATG
ATTTAGACAACTTCAAAATACAGAAGAAAAGCAAATGACTAGTAAACATGTGGGAAAAAATATTACATTTTAAGGGGGAAAAAAAAACCC

>8429_8429_8_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000608853_MTAP_chr9_21859301_ENST00000460874_length(amino acids)=189AA_BP=
MPRPGLPPPEVAATTEEGAVAEDEETEDEDGEGAAAGDARRPLPPGLRTLAAAGGGCCCCCCCCCCCCCCCCCCCCCCWGFSDMVRGPYT
GSHAGRGQPGAGRAKETPERGGDARAPSGEARVGAAGGAPGLARGRRRTTKGRGGPPRPRSRREPGRNAPPPLPLLPKQSEAEGGELCRE

--------------------------------------------------------------
>8429_8429_9_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000608853_MTAP_chr9_21859301_ENST00000580900_length(transcript)=1330nt_BP=567nt
TCCCCCGCCCGGCCCCGGCCCCCCTCCCTCCCGGCAGAGCTCGCCTCCCTCCGCCTCAGACTGTTTTGGTAGCAACGGCAACGGCGGCGG
CGCGTTTCGGCCCGGCTCCCGGCGGCTCCTTGGTCTCGGCGGGCCTCCCCGCCCCTTCGTCGTCCTCCTTCTCCCCCTCGCCAGCCCGGG
CGCCCCTCCGGCCGCGCCAACCCGCGCCTCCCCGCTCGGCGCCCGCGCGTCCCCGCCGCGTTCCGGCGTCTCCTTGGCGCGCCCGGCTCC
CGGCTGTCCCCGCCCGGCGTGCGAGCCGGTGTATGGGCCCCTCACCATGTCGCTGAAGCCCCAGCAGCAGCAGCAGCAGCAGCAGCAGCA
GCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCCGCCGCCCGCGGCTGCCAATGTCCGCAAGCCCGGCGGCAGCGGCCTTCT
AGCGTCGCCCGCCGCCGCGCCTTCGCCGTCCTCGTCCTCGGTCTCCTCGTCCTCGGCCACGGCTCCCTCCTCGGTGGTCGCGGCGACCTC
CGGCGGCGGGAGGCCCGGCCTGGGCAGGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTG
CTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGATGATCAAGTTCCAGATGATCCTCAGTGAG
GGATACCATCCTTTCAATATTCAAGAGTCACCCTTCTACAGAGGACTCCTAGACTTCCCATCAGTGGGACATGGCAGAGGTGAAATCCTG
CCCCTGTCTCCCTTAGACCTGGCTGGATACTGCTTCCAACAACCCATGCAGCCACCCTGCCCTGACAGCTAGCAAGAGGCCAAGACCCAC
AGAACAATCACCATCACACCTCTGTCAGCAGGAAGCAGTTACAGAAGACTGACCTTCATCCAGTTTCCCAAAGAATTGGGTCATGGATTT
TTGCGGGGGAAAATGTTAGAGTAGGTAATTAGGCAGACATGAGTAAGGGAGGAGAGACCCCCTCCAACTAGGAATGTCAGGTGAGCATCA
GATGATCATCAGGTGGTTGTTAAACTCTCTCTCTAAAATAATAATAGGTTGCAACTGGCAGCAGGGAAAGACAATCTCCCAATAGATAGA
AAAGTCCTGAAGCTGGTGATCAGCAGCTTCCTAGTAAGATCTCAGGATTTGGGCAAGCAGGCTCAAACATGGGCACTAAGAGGCAAAATC

>8429_8429_9_ATXN2-MTAP_ATXN2_chr12_112036587_ENST00000608853_MTAP_chr9_21859301_ENST00000580900_length(amino acids)=202AA_BP=20
MSPPGVRAGVWAPHHVAEAPAAAAAAAAAAAAATAAAAAAAAAAARGCQCPQARRQRPSSVARRRAFAVLVLGLLVLGHGSLLGGRGDLR
RREARPGQVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKMIKFQMILSEGYHPFNIQESPFYRGLLDFPSVGHGRGEILP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATXN2-MTAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATXN2-MTAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATXN2-MTAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATXN2C0752121Spinocerebellar Ataxia Type 23CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneATXN2C0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
HgeneATXN2C0087012Ataxia, Spinocerebellar2CTD_human
HgeneATXN2C0752120Spinocerebellar Ataxia Type 12CTD_human
HgeneATXN2C0752122Spinocerebellar Ataxia Type 42CTD_human
HgeneATXN2C0752123Spinocerebellar Ataxia Type 52CTD_human
HgeneATXN2C0752124Spinocerebellar Ataxia Type 6 (disorder)2CTD_human
HgeneATXN2C0752125Spinocerebellar Ataxia Type 72CTD_human
HgeneATXN2C0017612Glaucoma, Open-Angle1CTD_human
HgeneATXN2C0036341Schizophrenia1PSYGENET
HgeneATXN2C0271148Secondary Open Angle Glaucoma1CTD_human
HgeneATXN2C0339573Glaucoma, Primary Open Angle1CTD_human
HgeneATXN2C0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneATXN2C0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneC0025202melanoma1CTD_human
TgeneC0027960Nevus1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC1862177Diaphyseal medullary stenosis with malignant fibrous histiocytoma1CTD_human;GENOMICS_ENGLAND;ORPHANET