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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATL2-ACER3 (FusionGDB2 ID:HG64225TG55331)

Fusion Gene Summary for ATL2-ACER3

check button Fusion gene summary
Fusion gene informationFusion gene name: ATL2-ACER3
Fusion gene ID: hg64225tg55331
HgeneTgene
Gene symbol

ATL2

ACER3

Gene ID

64225

55331

Gene nameatlastin GTPase 2alkaline ceramidase 3
SynonymsARL3IP2|ARL6IP2|aip-2|atlastin2APHC|PHCA|PLDECO
Cytomap('ATL2')('ACER3')

2p22.2-p22.1

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionatlastin-2ADP-ribosylation factor-like protein 6-interacting protein 2ARL-6-interacting protein 2alkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkaline
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000332337, ENST00000378954, 
ENST00000402054, ENST00000406122, 
ENST00000419554, ENST00000452935, 
ENST00000539122, ENST00000546051, 
ENST00000486927, 
Fusion gene scores* DoF score14 X 10 X 5=70013 X 10 X 5=650
# samples 1615
** MAII scorelog2(16/700*10)=-2.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/650*10)=-2.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATL2 [Title/Abstract] AND ACER3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATL2(38540292)-ACER3(76637600), # samples:1
Anticipated loss of major functional domain due to fusion event.ATL2-ACER3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATL2-ACER3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATL2-ACER3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATL2-ACER3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ATL2-ACER3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATL2

GO:0051260

protein homooligomerization

18270207

TgeneACER3

GO:0043067

regulation of programmed cell death

20068046

TgeneACER3

GO:0046512

sphingosine biosynthetic process

20068046

TgeneACER3

GO:0046514

ceramide catabolic process

30575723

TgeneACER3

GO:0071602

phytosphingosine biosynthetic process

11356846|20068046


check buttonFusion gene breakpoints across ATL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ACER3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7958ATL2chr2

38540292

-ACER3chr11

76637600

+


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Fusion Gene ORF analysis for ATL2-ACER3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000332337ENST00000530182ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-3UTRENST00000378954ENST00000530182ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-3UTRENST00000402054ENST00000530182ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-3UTRENST00000406122ENST00000530182ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-3UTRENST00000419554ENST00000530182ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-3UTRENST00000452935ENST00000530182ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-3UTRENST00000539122ENST00000530182ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-3UTRENST00000546051ENST00000530182ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000332337ENST00000526597ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000332337ENST00000538157ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000378954ENST00000526597ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000378954ENST00000538157ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000402054ENST00000526597ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000402054ENST00000538157ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000406122ENST00000526597ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000406122ENST00000538157ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000419554ENST00000526597ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000419554ENST00000538157ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000452935ENST00000526597ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000452935ENST00000538157ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000539122ENST00000526597ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000539122ENST00000538157ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000546051ENST00000526597ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-5UTRENST00000546051ENST00000538157ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000332337ENST00000533873ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000332337ENST00000544113ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000378954ENST00000533873ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000378954ENST00000544113ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000402054ENST00000533873ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000402054ENST00000544113ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000406122ENST00000533873ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000406122ENST00000544113ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000419554ENST00000533873ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000419554ENST00000544113ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000452935ENST00000533873ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000452935ENST00000544113ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000539122ENST00000533873ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000539122ENST00000544113ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000546051ENST00000533873ATL2chr2

38540292

-ACER3chr11

76637600

+
5CDS-intronENST00000546051ENST00000544113ATL2chr2

38540292

-ACER3chr11

76637600

+
Frame-shiftENST00000332337ENST00000532485ATL2chr2

38540292

-ACER3chr11

76637600

+
Frame-shiftENST00000378954ENST00000532485ATL2chr2

38540292

-ACER3chr11

76637600

+
Frame-shiftENST00000406122ENST00000532485ATL2chr2

38540292

-ACER3chr11

76637600

+
Frame-shiftENST00000419554ENST00000532485ATL2chr2

38540292

-ACER3chr11

76637600

+
Frame-shiftENST00000452935ENST00000532485ATL2chr2

38540292

-ACER3chr11

76637600

+
Frame-shiftENST00000539122ENST00000532485ATL2chr2

38540292

-ACER3chr11

76637600

+
In-frameENST00000402054ENST00000532485ATL2chr2

38540292

-ACER3chr11

76637600

+
In-frameENST00000546051ENST00000532485ATL2chr2

38540292

-ACER3chr11

76637600

+
intron-3CDSENST00000486927ENST00000532485ATL2chr2

38540292

-ACER3chr11

76637600

+
intron-3UTRENST00000486927ENST00000530182ATL2chr2

38540292

-ACER3chr11

76637600

+
intron-5UTRENST00000486927ENST00000526597ATL2chr2

38540292

-ACER3chr11

76637600

+
intron-5UTRENST00000486927ENST00000538157ATL2chr2

38540292

-ACER3chr11

76637600

+
intron-intronENST00000486927ENST00000533873ATL2chr2

38540292

-ACER3chr11

76637600

+
intron-intronENST00000486927ENST00000544113ATL2chr2

38540292

-ACER3chr11

76637600

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402054ATL2chr238540292-ENST00000532485ACER3chr1176637600+77215505671250227
ENST00000546051ATL2chr238540292-ENST00000532485ACER3chr1176637600+77215505671250227

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402054ENST00000532485ATL2chr238540292-ACER3chr1176637600+0.036059590.96394044
ENST00000546051ENST00000532485ATL2chr238540292-ACER3chr1176637600+0.036059590.96394044

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Fusion Genomic Features for ATL2-ACER3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATL2chr238540292-ACER3chr1176637600+0.0140624570.98593754
ATL2chr238540292-ACER3chr1176637600+0.0140624570.98593754

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATL2-ACER3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:38540292/chr11:76637600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-714101_108250567.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-714145_147250567.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-714244_245250567.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-713101_108268584.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-713145_147268584.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-713244_245268584.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-713101_108268580.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-713145_147268580.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-713244_245268580.0Nucleotide bindingGTP
TgeneACER3chr2:38540292chr11:76637600ENST00000532485011109_11834268.0Topological domainLumenal
TgeneACER3chr2:38540292chr11:76637600ENST00000532485011140_14134268.0Topological domainCytoplasmic
TgeneACER3chr2:38540292chr11:76637600ENST00000532485011163_17334268.0Topological domainLumenal
TgeneACER3chr2:38540292chr11:76637600ENST00000532485011195_21534268.0Topological domainCytoplasmic
TgeneACER3chr2:38540292chr11:76637600ENST00000532485011237_26734268.0Topological domainLumenal
TgeneACER3chr2:38540292chr11:76637600ENST0000053248501156_6134268.0Topological domainLumenal
TgeneACER3chr2:38540292chr11:76637600ENST0000053248501183_8734268.0Topological domainCytoplasmic
TgeneACER3chr2:38540292chr11:76637600ENST0000054411306109_1180135.0Topological domainLumenal
TgeneACER3chr2:38540292chr11:76637600ENST0000054411306140_1410135.0Topological domainCytoplasmic
TgeneACER3chr2:38540292chr11:76637600ENST0000054411306163_1730135.0Topological domainLumenal
TgeneACER3chr2:38540292chr11:76637600ENST0000054411306195_2150135.0Topological domainCytoplasmic
TgeneACER3chr2:38540292chr11:76637600ENST00000544113061_330135.0Topological domainCytoplasmic
TgeneACER3chr2:38540292chr11:76637600ENST0000054411306237_2670135.0Topological domainLumenal
TgeneACER3chr2:38540292chr11:76637600ENST000005441130656_610135.0Topological domainLumenal
TgeneACER3chr2:38540292chr11:76637600ENST000005441130683_870135.0Topological domainCytoplasmic
TgeneACER3chr2:38540292chr11:76637600ENST00000532485011119_13934268.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST00000532485011142_16234268.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST00000532485011174_19434268.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST00000532485011216_23634268.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST0000053248501134_5534268.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST0000053248501162_8234268.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST0000053248501188_10834268.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST0000054411306119_1390135.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST0000054411306142_1620135.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST0000054411306174_1940135.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST0000054411306216_2360135.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST000005441130634_550135.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST000005441130662_820135.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST000005441130688_1080135.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-714256_284250567.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-713256_284268584.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-612256_28497413.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-713256_284268580.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-612256_28497413.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-71491_336250567.0DomainGB1/RHD3-type G
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-71391_336268584.0DomainGB1/RHD3-type G
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-61291_33697413.0DomainGB1/RHD3-type G
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-71391_336268580.0DomainGB1/RHD3-type G
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-61291_33697413.0DomainGB1/RHD3-type G
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-714303_306250567.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-713303_306268584.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-612101_10897413.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-612145_14797413.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-612244_24597413.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-612303_30697413.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-713303_306268580.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-612101_10897413.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-612145_14797413.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-612244_24597413.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-612303_30697413.0Nucleotide bindingGTP
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-7141_476250567.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-714498_499250567.0Topological domainLumenal
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-714521_583250567.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-7131_476268584.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-713498_499268584.0Topological domainLumenal
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-713521_583268584.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-6121_47697413.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-612498_49997413.0Topological domainLumenal
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-612521_58397413.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-7131_476268580.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-713498_499268580.0Topological domainLumenal
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-713521_583268580.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-6121_47697413.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-612498_49997413.0Topological domainLumenal
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-612521_58397413.0Topological domainCytoplasmic
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-714477_497250567.0TransmembraneHelical
HgeneATL2chr2:38540292chr11:76637600ENST00000332337-714500_520250567.0TransmembraneHelical
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-713477_497268584.0TransmembraneHelical
HgeneATL2chr2:38540292chr11:76637600ENST00000378954-713500_520268584.0TransmembraneHelical
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-612477_49797413.0TransmembraneHelical
HgeneATL2chr2:38540292chr11:76637600ENST00000402054-612500_52097413.0TransmembraneHelical
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-713477_497268580.0TransmembraneHelical
HgeneATL2chr2:38540292chr11:76637600ENST00000419554-713500_520268580.0TransmembraneHelical
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-612477_49797413.0TransmembraneHelical
HgeneATL2chr2:38540292chr11:76637600ENST00000539122-612500_52097413.0TransmembraneHelical
TgeneACER3chr2:38540292chr11:76637600ENST000005324850111_3334268.0Topological domainCytoplasmic


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Fusion Gene Sequence for ATL2-ACER3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7637_7637_1_ATL2-ACER3_ATL2_chr2_38540292_ENST00000402054_ACER3_chr11_76637600_ENST00000532485_length(transcript)=7721nt_BP=550nt
ACTGTGGTGCGAATTGATCGCATGAAATCCTGATTGAAAATTTTGATGGTACTTAAGAAAGGCATAAAGTTTTTTCAAAGGCTTATAAAT
AGTAAAAGCCTACGATTTGGATTCTCAAAGTTGGATTGGTGGAAACAATGAACCATTGACAGGCTTTACATGGCGAGGTGGCTGTGAAAG
AGAAACAACAGGCATACAAGTTTGGAATGAAGTATTTGTGATTGACAGACCTAATGGAACTAAAGTTGCTGTGCTGCTTATGGATACCCA
GGGTGCCTTTGATAGCCAGTCAACTATCAAAGACTGTGCAACGGTGTTTGCTCTGAGCACTATGACTAGCTCTGTCCAGGTATATAATCT
GTCTCAGAATATTCAAGAAGATGATCTTCAACATTTGCAATTATTTACAGAGTATGGAAGACTTGCGATGGAAGAAATCTACCAGAAACC
ATTTCAGACATTAATGTTTTTGATTCGAGATTGGAGCTATCCTTATGAACATTCATATGGTTTGGAAGGTGGAAAGCAATTTCTTGAAAA
GAGATTACAGGGAATACAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTAGAGACGGTCTGGAAAAG
CGGTACATTGCTTCTTATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAATATGAAATGCAGCTATTG
GATGAACTCCCAATGATATACAGCTGTTGCATATTTGTGTACTGCATGTTTGAATGTTTCAAGATCAAGAACTCAGTAAACTACCATCTG
CTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTTACCTTAAGGTAAAAGAGCCGATATTCCATCAGGTCATGTATGGAATG
TTGGTCTTTACATTAGTACTTCGATCTATTTATATTGTTACATGGGTTTATCCATGGCTTAGAGGACTGGGTTATACATCATTGGGTATA
TTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTTGTGAGTCACTGAGGAACTTTCGAAAGAAGGTACCACCTATCATAGGT
ATTACCACACAATTTCATGCATGGTGGCATATTTTAACTGGCCTTGGTTCCTATCTTCACATCCTTTTCAGTTTGTATACAAGAACACTT
TACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCTGGCCAGTGATCCTGTTTGAGCCTCTCAGGAAGCATTGATGAATCATT
CCACCAAGAAAACAAACAAGCACCTACCATAGACCTGGCAGAATAAATAAGGAAATCCTTAAAGATCTACAAGTTCAAATATGTCATGAC
CATCACAGCAGAGGAGTGACTTTCTGACTAATGCTGCCACCCACACAGAGAATAAGGAGTAGGGCCTGCTGGGTGTTTAGCTCATGGCTT
TATCTTATTTGTCCCCCTCCTCCTTTCACGCTCCAGTTTATAAAGAAACAGAGATGATGTGTGTGTATGCCTCAAATGCAGAAACAGTTG
GGCTTTTCTTAACAGGTTAACAGTTTGTGCTGGTTATAAGAAATTAACCTTCTTTTCTTTTTGCCAAGGGTTGCATGTGAATTATACCTT
TCTTAATATTTGATTAAATAATGCAGTCAGCTAAGAGCCAACAAAACCCCATATCCAGATAGTTAGCTGTGAGCCAGCACTCAGCTGTGT
CAGATTTGATTAATATTGTATTAATCTCATGGATGGTTCTCAAAGGTAAAAAAAGAGAGAGAAAGAGAGAGAGCTAGCTGTGGGATTCTG
TGTAGTTCTTCACTATCTGTTCCAGGGCTAGTCGGAGGATCATAAGCAAGCTCAGACCTGCCCCCAGTTCAGTACTTGACCACATCCCAG
GATTTATGGTGTCTGTCTATGGCCACAGCCAACCAGAATGAGTGGGTCATCTTATAACCTTTCTGAAGCTCCATGAGGACATGTATAGAA
TGCTGCACCTTCAGCCAGCTCTGCTCTGATCTTTGCAGATCTTTAAGTTGTCACTGTTTCTACGGCTAGACAAATATGACTGGTGGTCTA
GACTACCCATAGTTCATCCTCCTCACATAACTTATTTGAAGTTGTCAGGGAATGTCATTACACTCTGATTTTTAAAATTATGCAGTATTT
TCCAGTTCTCAGAGAGGTCATGGTTGTGCCCAGGGAAGTGTGTTGCATTAACTAAAGCTAAAATTATCAGAATCCTATTTACATAAAGCA
TATTAAAATATCTGCTCCTTAATTTTCTGAAGGAAATAGATGTAAGTTTCTGCTACTTGAAACCTACAGAACCGACAAAAATTAGGGTGC
TAAAAAAATGACAGTGAAATCTCATCGTAAGGCAGCTAGTTCTAATTTGCATTTGAATGTATAACAAATTGCATCACTTTTCACAAACTT
AACACCTGCCTGGAGTAAAAATCTGATTTGACCCCTCTGCTCATGTTTCATCATATTTGTAGCTCTGCATCATTTAGCATTTTTATGACT
TTTTTTGCTTTATATAAATTATTGTAAAATCCAGATTGTTTTTACCACATGATGACGTGACTCAGGATTAAATCCTGAGCTACAGTTTCA
AAAGGAAAATCATTTTTTTCTTATGCAAAGATGGTAAAACACTGTTGTCATTTTTTCCAGTATTCAATAAGTAGCCTTTGTACAAATTTA
AAACCAAAAACTATTCTGTTGTTTTTCTTCACCTACTAGCCTTAGTTTTTAACCAAGTATCCAAGGATGTCAACTTGACATCCTTCCCTT
AGCATGCCAACAAGCCATTAGACTGATTCTTCCACCTATTTTTATGAACCTCCAGGAAGAAAAACACTTGCCAAAACATTAAGAGAACTT
TGATTCTGCCTTAAGAGGGTATAAAACTAAACCATTTGAAGGCACAGCCCATAAGACTATACTTGATTTTGCCCCAAGATTCTGACTTCT
GGCTACATTTCACCTGCAGTTACCTGGGCTATCGGCCGTGATACATTTTTTAATTCATTTGTTTTCCACCATTATATTTTTATACTTTTC
AGTTAGATATACTTCTGCATAAAGAGTATATATACAGTGTAGGATAAAGGCATATCGTACATGGCAATGCTGTTAAACATGGTAAGACTG
AGGTTCTGCAGGATTAAAGTCAGATTAAGGGTACAGAAAGCACACCTTGATACTGAGGCCATTTAGAGCAATTTGTTTAATGAGTGGTTC
AGCCATCACCACCAGTGGCCACCTGTTCAATAAAATTGCCTAGCACCACAGTGGAGAGTCATCTACACCCCAAGGTGAGCTGTAAGACTG
GCCAATTCTTTGAAGACCTTTTTTTCTGTTGGGAGAATGGAAAGCAGAAAGGGAAGCCAGGCTCTTTAATGTTCCAAGTCAGCTGTGCCT
CACACAAGGCTCTCTTTTTAGCTACTAAGTAACATACTCAAGACTTTGTATCTGTGCAGCATTTTATGGAAATCACTGGTGACCTATAGG
ATATTACTAAATTATTTCAATAGCTTTATTTTTTTCCTACTTGGATTCTAGGTGGACATTACAGAGTTGAATTCCTCACTACCCCCTCCC
GCTGTCATTTGTTTTATTGGAAAACTTCATGTTAACTAGAGTGTACAAAAAGTCTGTTTCCTGCTGAGCCAATAGTGATTTGTTTGCATA
TCACCTAATGTGAAAAGTGCTCATCTGTGAACTCTACAGCAAATTATATTTTAGAAAATACTTTGTGAGGCCGGGCATGGTGGCAGAGCG
AGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAAGAAAATATAAGGATGTAAAAGAAGCAATTTGCTTGCACATCTGA
ATATCCTTCTTGTGCCTCCATTTTCACTCTTGAAAACTGAAAGCAATTTGACTTTTATTTTTGTTTTTCTAAAGAACAGCTAGGTGAAAG
GAGGTTAAGCTGATTGTCACTCTGCCTGCCCACTACCTACTCCCCACCATGGTGTTTCATGAAACATCCCCACCACCTGAAGTGATCTTT
TTAATCCTTGTGATAGTAAATGCATTGATAATTAACAGGAAAAACATGTTTTTAAATAATCTACAAATGAGAACCCAAATAGTAGTGTTT
TGTTTGACAGAAGTAAATCAAATATTATGGTTTAAATATAATGCAAAATTTCAGGACAGTTAATTTGGACTTCCCTTACCCTAAGAGGGT
TTTTCTTATAATAAGGAGAAGAGGTGTGGTTCAAAGAAAATTAAGAGACAAAACCTTCAGGTACATAATGCATGAAAATCTTTAAATGCC
TGCAAAAATTAAGTTCTGTTATAATACCAGCCAATTCTGAATTAGCCAATGCCCTAAAAGCATCTAACAATTTAAGGTTATCTTATGAGT
CCTATGAAAACAATTATTTGTTGCTAAATTTGAGTTTTAGCTACCAACGCCATGTTTACGTGACAAGAAATTGTTTTGGCCCTGTGGTTT
ATGACGTGCTGCTGGATAAGCATTTATGTAAAACTGAGTATTTCAAAGAGAACCATTTACAATTGGAATTTCCACCTGTGTGGCTGTTTG
CAGACCTACCTCTGTCTTCCATTTTGCATCCTGTCAGTGCTATAATTAGTTTGATCACTTTGTCTTGTTTTTCAGTGTCTACAATTATAG
CTTATTCACTATGTTCTAACTATTTAAAAATAATGGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGA
GCAGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGTCGGGCAT
GGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCAAGA
TTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAGACTAAAATTTGATT
TAAAGTAGTTAAACCCCTTTATGGAAGGAGCTGCAAAATGAAAAAAAAAAAAAAAAGGAATCATGTCATCTTGACCCAGCTGACTGGAAA
TTTTCAATACTGTCTTTTAACTGTTGTACTCCAGCCAGCCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAGAATTAGGAAATACTTGTTAAAATATCTAACTACGTAATTGCTACATGGGGGAGCTGCTGGTGTTGTTGAGGTCCTTGGGAGCAT
TCCACTGGACTTCACCATTTCTCCAAAATTATCAGCCCAGTCAGCTTCATATACCCAGATATGGACACTTCTACACGTGAAATTCAAACT
GAAGATAAAACTCTGACTTTGGAGTATAAACTTTTGCCTTGAGTATGAAACCTTGACATTGCTGAAAGAAAAGTGGAAACTGTAAGGGAC
AACAAGTTTCACCAAGGCACAGTCTTCTCTGATAGGCCAGCAGAGCAGCTAAGGAGAAGACAGATCATTCAAGAACTTAAGTCGTTTGTT
AGCTACAGCATTTCCATTGCTGTGATACACATTCAGCCATTTTGGAGGAAAGCTAAGCAGGTTCTGACCACCCATTTTCATGTACTTTAA
ATAACAAATATTATTTCTCAAGGTCTTCATTTTATCATTAAATTCAGCTAATTACTACCTGATTTCAAAGGCAGCTAGTGTAGAAGACTG
GTCACAAGAATTTTTTTTTAAATAGAAAACCCTAAAATGCAAATCAAGAAATTCAGTTACAGGCTGCAAGTGACCTAAAATTCCCCTACT
CTAGCTCAGCAGCCATCAGTCAGTATAGCATCAGCCACAGGTCACTGCTCTGCATACAGTTCCTTTTCAACCCTTACAAGACCTGCTTCA
TTGCTTTAAAAATGTAGTGTTGATACTTGAACTGAATTTAGTCATTGGTAACTTAAATATTCACAAAATTGTCATAAAGCTTCTGAAACA
TCTGGCAATGCCAGATCTGTAATCATCACTTTTAAATTGAATTTGCAGAATTAACTCTAAAGTTGCAGCAACCATATTTATTAGAGAAAT
CTTTAAGCATATACATATGGTTCCCTATAAGCATTCATTCAGAGATCATCTGTGCCTAAAAGAAAATGATAAAAATGTGTCATAATATCA
AAGGGGTCTAGATCAGGGGTTGGTAAACTACAACCCATGGGCCAAATTCAGGCTGCGTTGTATGGCCTGCAAGGTAAGAATGGTTATTTT
ATTTTATTTTATTCTTTATATATATATATATATATTTATTTATTTTTTTGAGACAGAGTCTCTCTCTGTCACCCACGCTGGAGTGCAGTG
GCAGGATCTCAACTCATTGCAACCTCCGCCTCCCAAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACA
TGCCACCATGCCACCATGCCTGGCTGATTTTTGTATTTTTAGTAGAGCTGGGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGAT
TCACCTGCCTTGGCCTCCCAAAGTCCTGGAATTACAGGCGTGAGCTACCGTGCCCAGCTGGTTTTTACATTTTAAAAACGTTTAGAGAAA
GAAGAATATGCAACAGAAACTGTATGTAGCCTGCAAAGCCTAAAATGTTTACTCTCTGGCTTGGGAGTTTGTCTCCCCTGCTCTAGACTG
TCAGCAAGTGGTACAGTGGTACAGTACAGTGGTACTGCCCAACTGCACTTCTCTGCAAGGTGATTCTAGTGTGCACTTGTCAGAATGAAA
ATATGTTATTCATTTAAGACATCTCATGTCTTTGAATGTAATCACATGATTTGTATTTAATATTTACATGACCTAATTATTTTTTCACGT
CAGTTTTTCTAGATTGGCAATAGCCTGTTGCAAAGTGCCTAAACCTTTGAGAAAAATTACTATGAGCAAGGTCCATGATTTAGTTTTCAA
TATAAAGGGAATTCCATTCTATACTGTAAAATCCAAAAATGCTAGTTGCCCTCAGCTTTTGAGTTGACTTCCAGAAAGTTGAGATCTTTT
GACCATTTTTTCTCATGTCATATAAAATGTGCCACATGGTAGTTGTCAAGCTGTGGTAGTCATGTACACTTTTTTTCTTTTTTTTAACTT
TCTAAAAGGAAAAGTTCAAAGTCCTTTCCACAGTTAGTCTTCGCTTCTTTTGGATTTTTCTTTTTAGAGCTAAATTATTCATACCAATGA
ATAAGTGAGTCTGTTCTAAGATATAGGGGCCATTATCTATTTTTGCTTAATGGACTCATGTGGCATTGTTCACTATCATGCCTTTCCATA
CTTGTAATATTTCTGAGTCACTTATTAATGTGACCAACAGATAAACTGTTCAAGCTAATACAGCATTTCCTAACTTCATAGTTGTCGCAG
ATGTTTGTTCTAGTAGCGATTATTTAATAAACATACATTGTACTGAATCTTACTAGCAACTAACTATTTTCAGGTAATCTCAGTCTGCTT
ATTCACTTTTTCCATTTGATTTGCTAATGCCACAATCATTTTTCTAGAAAATAGTAGGATAATGTATTTTTTCCTGTCTGCTATAATGGA

>7637_7637_1_ATL2-ACER3_ATL2_chr2_38540292_ENST00000402054_ACER3_chr11_76637600_ENST00000532485_length(amino acids)=227AA_BP=
MIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSL
IVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWW

--------------------------------------------------------------
>7637_7637_2_ATL2-ACER3_ATL2_chr2_38540292_ENST00000546051_ACER3_chr11_76637600_ENST00000532485_length(transcript)=7721nt_BP=550nt
ACTGTGGTGCGAATTGATCGCATGAAATCCTGATTGAAAATTTTGATGGTACTTAAGAAAGGCATAAAGTTTTTTCAAAGGCTTATAAAT
AGTAAAAGCCTACGATTTGGATTCTCAAAGTTGGATTGGTGGAAACAATGAACCATTGACAGGCTTTACATGGCGAGGTGGCTGTGAAAG
AGAAACAACAGGCATACAAGTTTGGAATGAAGTATTTGTGATTGACAGACCTAATGGAACTAAAGTTGCTGTGCTGCTTATGGATACCCA
GGGTGCCTTTGATAGCCAGTCAACTATCAAAGACTGTGCAACGGTGTTTGCTCTGAGCACTATGACTAGCTCTGTCCAGGTATATAATCT
GTCTCAGAATATTCAAGAAGATGATCTTCAACATTTGCAATTATTTACAGAGTATGGAAGACTTGCGATGGAAGAAATCTACCAGAAACC
ATTTCAGACATTAATGTTTTTGATTCGAGATTGGAGCTATCCTTATGAACATTCATATGGTTTGGAAGGTGGAAAGCAATTTCTTGAAAA
GAGATTACAGGGAATACAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTAGAGACGGTCTGGAAAAG
CGGTACATTGCTTCTTATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAATATGAAATGCAGCTATTG
GATGAACTCCCAATGATATACAGCTGTTGCATATTTGTGTACTGCATGTTTGAATGTTTCAAGATCAAGAACTCAGTAAACTACCATCTG
CTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTTACCTTAAGGTAAAAGAGCCGATATTCCATCAGGTCATGTATGGAATG
TTGGTCTTTACATTAGTACTTCGATCTATTTATATTGTTACATGGGTTTATCCATGGCTTAGAGGACTGGGTTATACATCATTGGGTATA
TTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTTGTGAGTCACTGAGGAACTTTCGAAAGAAGGTACCACCTATCATAGGT
ATTACCACACAATTTCATGCATGGTGGCATATTTTAACTGGCCTTGGTTCCTATCTTCACATCCTTTTCAGTTTGTATACAAGAACACTT
TACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCTGGCCAGTGATCCTGTTTGAGCCTCTCAGGAAGCATTGATGAATCATT
CCACCAAGAAAACAAACAAGCACCTACCATAGACCTGGCAGAATAAATAAGGAAATCCTTAAAGATCTACAAGTTCAAATATGTCATGAC
CATCACAGCAGAGGAGTGACTTTCTGACTAATGCTGCCACCCACACAGAGAATAAGGAGTAGGGCCTGCTGGGTGTTTAGCTCATGGCTT
TATCTTATTTGTCCCCCTCCTCCTTTCACGCTCCAGTTTATAAAGAAACAGAGATGATGTGTGTGTATGCCTCAAATGCAGAAACAGTTG
GGCTTTTCTTAACAGGTTAACAGTTTGTGCTGGTTATAAGAAATTAACCTTCTTTTCTTTTTGCCAAGGGTTGCATGTGAATTATACCTT
TCTTAATATTTGATTAAATAATGCAGTCAGCTAAGAGCCAACAAAACCCCATATCCAGATAGTTAGCTGTGAGCCAGCACTCAGCTGTGT
CAGATTTGATTAATATTGTATTAATCTCATGGATGGTTCTCAAAGGTAAAAAAAGAGAGAGAAAGAGAGAGAGCTAGCTGTGGGATTCTG
TGTAGTTCTTCACTATCTGTTCCAGGGCTAGTCGGAGGATCATAAGCAAGCTCAGACCTGCCCCCAGTTCAGTACTTGACCACATCCCAG
GATTTATGGTGTCTGTCTATGGCCACAGCCAACCAGAATGAGTGGGTCATCTTATAACCTTTCTGAAGCTCCATGAGGACATGTATAGAA
TGCTGCACCTTCAGCCAGCTCTGCTCTGATCTTTGCAGATCTTTAAGTTGTCACTGTTTCTACGGCTAGACAAATATGACTGGTGGTCTA
GACTACCCATAGTTCATCCTCCTCACATAACTTATTTGAAGTTGTCAGGGAATGTCATTACACTCTGATTTTTAAAATTATGCAGTATTT
TCCAGTTCTCAGAGAGGTCATGGTTGTGCCCAGGGAAGTGTGTTGCATTAACTAAAGCTAAAATTATCAGAATCCTATTTACATAAAGCA
TATTAAAATATCTGCTCCTTAATTTTCTGAAGGAAATAGATGTAAGTTTCTGCTACTTGAAACCTACAGAACCGACAAAAATTAGGGTGC
TAAAAAAATGACAGTGAAATCTCATCGTAAGGCAGCTAGTTCTAATTTGCATTTGAATGTATAACAAATTGCATCACTTTTCACAAACTT
AACACCTGCCTGGAGTAAAAATCTGATTTGACCCCTCTGCTCATGTTTCATCATATTTGTAGCTCTGCATCATTTAGCATTTTTATGACT
TTTTTTGCTTTATATAAATTATTGTAAAATCCAGATTGTTTTTACCACATGATGACGTGACTCAGGATTAAATCCTGAGCTACAGTTTCA
AAAGGAAAATCATTTTTTTCTTATGCAAAGATGGTAAAACACTGTTGTCATTTTTTCCAGTATTCAATAAGTAGCCTTTGTACAAATTTA
AAACCAAAAACTATTCTGTTGTTTTTCTTCACCTACTAGCCTTAGTTTTTAACCAAGTATCCAAGGATGTCAACTTGACATCCTTCCCTT
AGCATGCCAACAAGCCATTAGACTGATTCTTCCACCTATTTTTATGAACCTCCAGGAAGAAAAACACTTGCCAAAACATTAAGAGAACTT
TGATTCTGCCTTAAGAGGGTATAAAACTAAACCATTTGAAGGCACAGCCCATAAGACTATACTTGATTTTGCCCCAAGATTCTGACTTCT
GGCTACATTTCACCTGCAGTTACCTGGGCTATCGGCCGTGATACATTTTTTAATTCATTTGTTTTCCACCATTATATTTTTATACTTTTC
AGTTAGATATACTTCTGCATAAAGAGTATATATACAGTGTAGGATAAAGGCATATCGTACATGGCAATGCTGTTAAACATGGTAAGACTG
AGGTTCTGCAGGATTAAAGTCAGATTAAGGGTACAGAAAGCACACCTTGATACTGAGGCCATTTAGAGCAATTTGTTTAATGAGTGGTTC
AGCCATCACCACCAGTGGCCACCTGTTCAATAAAATTGCCTAGCACCACAGTGGAGAGTCATCTACACCCCAAGGTGAGCTGTAAGACTG
GCCAATTCTTTGAAGACCTTTTTTTCTGTTGGGAGAATGGAAAGCAGAAAGGGAAGCCAGGCTCTTTAATGTTCCAAGTCAGCTGTGCCT
CACACAAGGCTCTCTTTTTAGCTACTAAGTAACATACTCAAGACTTTGTATCTGTGCAGCATTTTATGGAAATCACTGGTGACCTATAGG
ATATTACTAAATTATTTCAATAGCTTTATTTTTTTCCTACTTGGATTCTAGGTGGACATTACAGAGTTGAATTCCTCACTACCCCCTCCC
GCTGTCATTTGTTTTATTGGAAAACTTCATGTTAACTAGAGTGTACAAAAAGTCTGTTTCCTGCTGAGCCAATAGTGATTTGTTTGCATA
TCACCTAATGTGAAAAGTGCTCATCTGTGAACTCTACAGCAAATTATATTTTAGAAAATACTTTGTGAGGCCGGGCATGGTGGCAGAGCG
AGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAAGAAAATATAAGGATGTAAAAGAAGCAATTTGCTTGCACATCTGA
ATATCCTTCTTGTGCCTCCATTTTCACTCTTGAAAACTGAAAGCAATTTGACTTTTATTTTTGTTTTTCTAAAGAACAGCTAGGTGAAAG
GAGGTTAAGCTGATTGTCACTCTGCCTGCCCACTACCTACTCCCCACCATGGTGTTTCATGAAACATCCCCACCACCTGAAGTGATCTTT
TTAATCCTTGTGATAGTAAATGCATTGATAATTAACAGGAAAAACATGTTTTTAAATAATCTACAAATGAGAACCCAAATAGTAGTGTTT
TGTTTGACAGAAGTAAATCAAATATTATGGTTTAAATATAATGCAAAATTTCAGGACAGTTAATTTGGACTTCCCTTACCCTAAGAGGGT
TTTTCTTATAATAAGGAGAAGAGGTGTGGTTCAAAGAAAATTAAGAGACAAAACCTTCAGGTACATAATGCATGAAAATCTTTAAATGCC
TGCAAAAATTAAGTTCTGTTATAATACCAGCCAATTCTGAATTAGCCAATGCCCTAAAAGCATCTAACAATTTAAGGTTATCTTATGAGT
CCTATGAAAACAATTATTTGTTGCTAAATTTGAGTTTTAGCTACCAACGCCATGTTTACGTGACAAGAAATTGTTTTGGCCCTGTGGTTT
ATGACGTGCTGCTGGATAAGCATTTATGTAAAACTGAGTATTTCAAAGAGAACCATTTACAATTGGAATTTCCACCTGTGTGGCTGTTTG
CAGACCTACCTCTGTCTTCCATTTTGCATCCTGTCAGTGCTATAATTAGTTTGATCACTTTGTCTTGTTTTTCAGTGTCTACAATTATAG
CTTATTCACTATGTTCTAACTATTTAAAAATAATGGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGA
GCAGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGTCGGGCAT
GGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCAAGA
TTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAGACTAAAATTTGATT
TAAAGTAGTTAAACCCCTTTATGGAAGGAGCTGCAAAATGAAAAAAAAAAAAAAAAGGAATCATGTCATCTTGACCCAGCTGACTGGAAA
TTTTCAATACTGTCTTTTAACTGTTGTACTCCAGCCAGCCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAGAATTAGGAAATACTTGTTAAAATATCTAACTACGTAATTGCTACATGGGGGAGCTGCTGGTGTTGTTGAGGTCCTTGGGAGCAT
TCCACTGGACTTCACCATTTCTCCAAAATTATCAGCCCAGTCAGCTTCATATACCCAGATATGGACACTTCTACACGTGAAATTCAAACT
GAAGATAAAACTCTGACTTTGGAGTATAAACTTTTGCCTTGAGTATGAAACCTTGACATTGCTGAAAGAAAAGTGGAAACTGTAAGGGAC
AACAAGTTTCACCAAGGCACAGTCTTCTCTGATAGGCCAGCAGAGCAGCTAAGGAGAAGACAGATCATTCAAGAACTTAAGTCGTTTGTT
AGCTACAGCATTTCCATTGCTGTGATACACATTCAGCCATTTTGGAGGAAAGCTAAGCAGGTTCTGACCACCCATTTTCATGTACTTTAA
ATAACAAATATTATTTCTCAAGGTCTTCATTTTATCATTAAATTCAGCTAATTACTACCTGATTTCAAAGGCAGCTAGTGTAGAAGACTG
GTCACAAGAATTTTTTTTTAAATAGAAAACCCTAAAATGCAAATCAAGAAATTCAGTTACAGGCTGCAAGTGACCTAAAATTCCCCTACT
CTAGCTCAGCAGCCATCAGTCAGTATAGCATCAGCCACAGGTCACTGCTCTGCATACAGTTCCTTTTCAACCCTTACAAGACCTGCTTCA
TTGCTTTAAAAATGTAGTGTTGATACTTGAACTGAATTTAGTCATTGGTAACTTAAATATTCACAAAATTGTCATAAAGCTTCTGAAACA
TCTGGCAATGCCAGATCTGTAATCATCACTTTTAAATTGAATTTGCAGAATTAACTCTAAAGTTGCAGCAACCATATTTATTAGAGAAAT
CTTTAAGCATATACATATGGTTCCCTATAAGCATTCATTCAGAGATCATCTGTGCCTAAAAGAAAATGATAAAAATGTGTCATAATATCA
AAGGGGTCTAGATCAGGGGTTGGTAAACTACAACCCATGGGCCAAATTCAGGCTGCGTTGTATGGCCTGCAAGGTAAGAATGGTTATTTT
ATTTTATTTTATTCTTTATATATATATATATATATTTATTTATTTTTTTGAGACAGAGTCTCTCTCTGTCACCCACGCTGGAGTGCAGTG
GCAGGATCTCAACTCATTGCAACCTCCGCCTCCCAAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACA
TGCCACCATGCCACCATGCCTGGCTGATTTTTGTATTTTTAGTAGAGCTGGGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGAT
TCACCTGCCTTGGCCTCCCAAAGTCCTGGAATTACAGGCGTGAGCTACCGTGCCCAGCTGGTTTTTACATTTTAAAAACGTTTAGAGAAA
GAAGAATATGCAACAGAAACTGTATGTAGCCTGCAAAGCCTAAAATGTTTACTCTCTGGCTTGGGAGTTTGTCTCCCCTGCTCTAGACTG
TCAGCAAGTGGTACAGTGGTACAGTACAGTGGTACTGCCCAACTGCACTTCTCTGCAAGGTGATTCTAGTGTGCACTTGTCAGAATGAAA
ATATGTTATTCATTTAAGACATCTCATGTCTTTGAATGTAATCACATGATTTGTATTTAATATTTACATGACCTAATTATTTTTTCACGT
CAGTTTTTCTAGATTGGCAATAGCCTGTTGCAAAGTGCCTAAACCTTTGAGAAAAATTACTATGAGCAAGGTCCATGATTTAGTTTTCAA
TATAAAGGGAATTCCATTCTATACTGTAAAATCCAAAAATGCTAGTTGCCCTCAGCTTTTGAGTTGACTTCCAGAAAGTTGAGATCTTTT
GACCATTTTTTCTCATGTCATATAAAATGTGCCACATGGTAGTTGTCAAGCTGTGGTAGTCATGTACACTTTTTTTCTTTTTTTTAACTT
TCTAAAAGGAAAAGTTCAAAGTCCTTTCCACAGTTAGTCTTCGCTTCTTTTGGATTTTTCTTTTTAGAGCTAAATTATTCATACCAATGA
ATAAGTGAGTCTGTTCTAAGATATAGGGGCCATTATCTATTTTTGCTTAATGGACTCATGTGGCATTGTTCACTATCATGCCTTTCCATA
CTTGTAATATTTCTGAGTCACTTATTAATGTGACCAACAGATAAACTGTTCAAGCTAATACAGCATTTCCTAACTTCATAGTTGTCGCAG
ATGTTTGTTCTAGTAGCGATTATTTAATAAACATACATTGTACTGAATCTTACTAGCAACTAACTATTTTCAGGTAATCTCAGTCTGCTT
ATTCACTTTTTCCATTTGATTTGCTAATGCCACAATCATTTTTCTAGAAAATAGTAGGATAATGTATTTTTTCCTGTCTGCTATAATGGA

>7637_7637_2_ATL2-ACER3_ATL2_chr2_38540292_ENST00000546051_ACER3_chr11_76637600_ENST00000532485_length(amino acids)=227AA_BP=
MIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSL
IVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWW

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Fusion Gene PPI Analysis for ATL2-ACER3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATL2-ACER3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATL2-ACER3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4540358LEUKODYSTROPHY, PROGRESSIVE, EARLY CHILDHOOD-ONSET2ORPHANET;UNIPROT
TgeneC0025202melanoma1CTD_human