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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RGNEF-BTF3 (FusionGDB2 ID:HG64283TG689)

Fusion Gene Summary for RGNEF-BTF3

check button Fusion gene summary
Fusion gene informationFusion gene name: RGNEF-BTF3
Fusion gene ID: hg64283tg689
HgeneTgene
Gene symbol

RGNEF

BTF3

Gene ID

64283

689

Gene nameRho guanine nucleotide exchange factor 28basic transcription factor 3
SynonymsRGNEF|RIP2|p190RHOGEFBETA-NAC|BTF3a|BTF3b|NACB
Cytomap('ARHGEF28','RGNEF')('BTF3','BTF3')

5q13.2

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 28190 kDa guanine nucleotide exchange factorRho guanine nucleotide exchange factor (GEF) 28Rho interacting protein 2p190-RhoGEFrho-guanine nucleotide exchange factortranscription factor BTF3NAC-betaRNA polymerase B transcription factor 3nascent polypeptide-associated complex subunit betanascent-polypeptide-associated complex beta polypeptide
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000287898, ENST00000296794, 
ENST00000426542, ENST00000437974, 
ENST00000513042, ENST00000545377, 
ENST00000296799, ENST00000512883, 
ENST00000513841, 
Fusion gene scores* DoF score6 X 5 X 3=909 X 7 X 6=378
# samples 611
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/378*10)=-1.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RGNEF [Title/Abstract] AND BTF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF28(72980709)-BTF3(72798313), # samples:3
RGNEF(72980709)-BTF3(72798312), # samples:3
Anticipated loss of major functional domain due to fusion event.ARHGEF28-BTF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF28-BTF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF28-BTF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF28-BTF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGEF28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BTF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-R6-A8W5ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
ChimerDB4LUSCTCGA-22-4607ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
ChimerDB4OVTCGA-29-1710-01AARHGEF28chr5

72980709

+BTF3chr5

72798313

+
ChimerDB4ESCATCGA-R6-A8W5RGNEFchr5

72980709

+BTF3chr5

72798312

+
ChimerDB4LUSCTCGA-22-4607RGNEFchr5

72980709

+BTF3chr5

72798312

+


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Fusion Gene ORF analysis for RGNEF-BTF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000287898ENST00000380591ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000287898ENST00000514505ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000296794ENST00000380591ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000296794ENST00000514505ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000426542ENST00000380591ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000426542ENST00000514505ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000437974ENST00000380591ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000437974ENST00000514505ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000513042ENST00000380591ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000513042ENST00000514505ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000545377ENST00000380591ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
5CDS-3UTRENST00000545377ENST00000514505ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
In-frameENST00000287898ENST00000335895ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
In-frameENST00000296794ENST00000335895ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
In-frameENST00000426542ENST00000335895ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
In-frameENST00000437974ENST00000335895ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
In-frameENST00000513042ENST00000335895ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
In-frameENST00000545377ENST00000335895ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
intron-3CDSENST00000296799ENST00000335895ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
intron-3CDSENST00000512883ENST00000335895ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
intron-3CDSENST00000513841ENST00000335895ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
intron-3UTRENST00000296799ENST00000380591ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
intron-3UTRENST00000296799ENST00000514505ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
intron-3UTRENST00000512883ENST00000380591ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
intron-3UTRENST00000512883ENST00000514505ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
intron-3UTRENST00000513841ENST00000380591ARHGEF28chr5

72980709

+BTF3chr5

72798313

+
intron-3UTRENST00000513841ENST00000514505ARHGEF28chr5

72980709

+BTF3chr5

72798313

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296794ARHGEF28chr572980709+ENST00000335895BTF3chr572798313+8862095628207
ENST00000287898ARHGEF28chr572980709+ENST00000335895BTF3chr572798313+8862095628207
ENST00000545377ARHGEF28chr572980709+ENST00000335895BTF3chr572798313+8862095628207
ENST00000513042ARHGEF28chr572980709+ENST00000335895BTF3chr572798313+8862095628207
ENST00000437974ARHGEF28chr572980709+ENST00000335895BTF3chr572798313+7305320472150
ENST00000426542ARHGEF28chr572980709+ENST00000335895BTF3chr572798313+7305320472150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296794ENST00000335895ARHGEF28chr572980709+BTF3chr572798313+0.0022865420.99771345
ENST00000287898ENST00000335895ARHGEF28chr572980709+BTF3chr572798313+0.0022865420.99771345
ENST00000545377ENST00000335895ARHGEF28chr572980709+BTF3chr572798313+0.0022865420.99771345
ENST00000513042ENST00000335895ARHGEF28chr572980709+BTF3chr572798313+0.0022865420.99771345
ENST00000437974ENST00000335895ARHGEF28chr572980709+BTF3chr572798313+0.0023235810.99767643
ENST00000426542ENST00000335895ARHGEF28chr572980709+BTF3chr572798313+0.0023235810.99767643

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Fusion Genomic Features for RGNEF-BTF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGEF28chr572980709+BTF3chr572798312+3.41E-081
ARHGEF28chr572980709+BTF3chr572798312+3.41E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RGNEF-BTF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:72980709/:72798313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBTF3chr5:72980709chr5:72798313ENST0000033589516185_18823163.0Compositional biasNote=Poly-Asp
TgeneBTF3chr5:72980709chr5:72798313ENST0000038059116185_18867207.0Compositional biasNote=Poly-Asp
TgeneBTF3chr5:72980709chr5:72798313ENST000003358951682_14723163.0DomainNAC-A/B
TgeneBTF3chr5:72980709chr5:72798313ENST000003805911682_14767207.0DomainNAC-A/B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000287898+2361488_1525111688.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296794+2351488_1525111652.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296799+1281488_152501393.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000426542+1351488_1525111706.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000437974+1361488_1525111732.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000513042+2361488_1525111706.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000545377+2371488_1525111732.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000287898+2361086_1188111688.0DomainPH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000287898+236849_1044111688.0DomainDH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296794+2351086_1188111652.0DomainPH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296794+235849_1044111652.0DomainDH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296799+1281086_118801393.0DomainPH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296799+128849_104401393.0DomainDH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000426542+1351086_1188111706.0DomainPH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000426542+135849_1044111706.0DomainDH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000437974+1361086_1188111732.0DomainPH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000437974+136849_1044111732.0DomainDH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000513042+2361086_1188111706.0DomainPH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000513042+236849_1044111706.0DomainDH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000545377+2371086_1188111732.0DomainPH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000545377+237849_1044111732.0DomainDH
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000287898+2361496_1527111688.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296794+2351496_1527111652.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296799+1281496_152701393.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000426542+1351496_1527111706.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000437974+1361496_1527111732.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000513042+2361496_1527111706.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000545377+2371496_1527111732.0RegionRNA-binding
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000287898+236652_699111688.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296794+235652_699111652.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296799+128652_69901393.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000426542+135652_699111706.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000437974+136652_699111732.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000513042+236652_699111706.0Zinc fingerPhorbol-ester/DAG-type
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000545377+237652_699111732.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for RGNEF-BTF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6275_6275_1_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000287898_BTF3_chr5_72798313_ENST00000335895_length(transcript)=886nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAAC
TTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACT
TTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTAC
CCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAG
CACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAA
TTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATG
GATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCAT
TCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTGAAACAAAGATTAATAAAGTTCTTTGCCTAGTA

>6275_6275_1_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000287898_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=207AA_BP=66
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYGTARRKKKVVHRTATADDKKLQ
FSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSLRRLAEALPKQSVDGKAP
LATGEDDDDEVPDLVENFDEASKNEAN

--------------------------------------------------------------
>6275_6275_2_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000296794_BTF3_chr5_72798313_ENST00000335895_length(transcript)=886nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAAC
TTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACT
TTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTAC
CCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAG
CACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAA
TTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATG
GATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCAT
TCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTGAAACAAAGATTAATAAAGTTCTTTGCCTAGTA

>6275_6275_2_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000296794_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=207AA_BP=66
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYGTARRKKKVVHRTATADDKKLQ
FSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSLRRLAEALPKQSVDGKAP
LATGEDDDDEVPDLVENFDEASKNEAN

--------------------------------------------------------------
>6275_6275_3_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000426542_BTF3_chr5_72798313_ENST00000335895_length(transcript)=730nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAA
CAGCCACAGCAGATGACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTA
CAAACCAAGGAACAGTGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGA
CAAAGCAGCTGACAGAAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGC
CCAAACAATCTGTGGATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGG
CTTCCAAGAATGAGGCAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTG
CTTTTTAAGAAATTTTTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTC
AGTTTTTGCTTATACACAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTGAAACAAAGATTAATAAAGTTCT
TTGCCTAGTA

>6275_6275_3_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000426542_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=150AA_BP=9
MELSCSEAPLYGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEM
LPSILNQLGADSLTSLRRLAEALPKQSVDGKAPLATGEDDDDEVPDLVENFDEASKNEAN

--------------------------------------------------------------
>6275_6275_4_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000437974_BTF3_chr5_72798313_ENST00000335895_length(transcript)=730nt_BP=53nt
TCATTGCAGATGCGAAAGCCATGGAGTTGAGCTGCAGCGAAGCACCTCTTTACGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAA
CAGCCACAGCAGATGACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTA
CAAACCAAGGAACAGTGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGA
CAAAGCAGCTGACAGAAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGC
CCAAACAATCTGTGGATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGG
CTTCCAAGAATGAGGCAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTG
CTTTTTAAGAAATTTTTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTC
AGTTTTTGCTTATACACAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTGAAACAAAGATTAATAAAGTTCT
TTGCCTAGTA

>6275_6275_4_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000437974_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=150AA_BP=9
MELSCSEAPLYGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEM
LPSILNQLGADSLTSLRRLAEALPKQSVDGKAPLATGEDDDDEVPDLVENFDEASKNEAN

--------------------------------------------------------------
>6275_6275_5_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000513042_BTF3_chr5_72798313_ENST00000335895_length(transcript)=886nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAAC
TTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACT
TTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTAC
CCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAG
CACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAA
TTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATG
GATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCAT
TCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTGAAACAAAGATTAATAAAGTTCTTTGCCTAGTA

>6275_6275_5_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000513042_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=207AA_BP=66
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYGTARRKKKVVHRTATADDKKLQ
FSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSLRRLAEALPKQSVDGKAP
LATGEDDDDEVPDLVENFDEASKNEAN

--------------------------------------------------------------
>6275_6275_6_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000545377_BTF3_chr5_72798313_ENST00000335895_length(transcript)=886nt_BP=209nt
AAACCTTGGCTTCAGCCCGGCCGCCGCCAGGCGTTGGCATCGCCGGGGAGAGCCTTCCGGACTCCGGGCGGCGGCTGGCTGGGGGCGCGT
TCCGAGGCGCCCTCAGGCAGGGCGCGGGGGCAGAGCCTCGCCTGGGTTCTGGAGGCTGCGGGGCCATCGCTCCAGATGCGAAAGCCATGG
AGTTGAGCTGCAGCGAAGCACCTCTTTACGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAAC
TTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACT
TTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTAC
CCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAG
CACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAA
TTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATG
GATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCAT
TCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTGAAACAAAGATTAATAAAGTTCTTTGCCTAGTA

>6275_6275_6_ARHGEF28-BTF3_ARHGEF28_chr5_72980709_ENST00000545377_BTF3_chr5_72798313_ENST00000335895_length(amino acids)=207AA_BP=66
MASARPPPGVGIAGESLPDSGRRLAGGAFRGALRQGAGAEPRLGSGGCGAIAPDAKAMELSCSEAPLYGTARRKKKVVHRTATADDKKLQ
FSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSLRRLAEALPKQSVDGKAP
LATGEDDDDEVPDLVENFDEASKNEAN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RGNEF-BTF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000287898+2361425_170511.01688.0microtubules
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296794+2351425_170511.01652.0microtubules
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296799+1281425_170501393.0microtubules
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000426542+1351425_170511.01706.0microtubules
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000437974+1361425_170511.01732.0microtubules
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000513042+2361425_170511.01706.0microtubules
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000545377+2371425_170511.01732.0microtubules
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000287898+2361295_130411.01688.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296794+2351295_130411.01652.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000296799+1281295_130401393.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000426542+1351295_130411.01706.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000437974+1361295_130411.01732.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000513042+2361295_130411.01706.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation
HgeneARHGEF28chr5:72980709chr5:72798313ENST00000545377+2371295_130411.01732.0PTK2/FAK1%3B required for regulation of axonal branching and synapse formation


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RGNEF-BTF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RGNEF-BTF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGEF28C0002736Amyotrophic Lateral Sclerosis1GENOMICS_ENGLAND