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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LMBR1-LINC01006 (FusionGDB2 ID:HG64327TG100506380)

Fusion Gene Summary for LMBR1-LINC01006

check button Fusion gene summary
Fusion gene informationFusion gene name: LMBR1-LINC01006
Fusion gene ID: hg64327tg100506380
HgeneTgene
Gene symbol

LMBR1

LINC01006

Gene ID

64327

100506380

Gene namelimb development membrane protein 1long intergenic non-protein coding RNA 1006
SynonymsACHP|C7orf2|DIF14|LSS|PPD2|THYP|TPT|ZRSC7orf13|MY040
Cytomap('LMBR1')('LINC01006')

7q36.3

7q36.3

Type of geneprotein-codingncRNA
Descriptionlimb region 1 protein homologdifferentiation-related gene 14 proteinlimb region 1 homolog-
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000353442, ENST00000354505, 
ENST00000359422, ENST00000540390, 
ENST00000430825, 
Fusion gene scores* DoF score14 X 11 X 12=18485 X 6 X 3=90
# samples 206
** MAII scorelog2(20/1848*10)=-3.20789285164133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMBR1 [Title/Abstract] AND LINC01006 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLMBR1(156549087)-LINC01006(156265405), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LMBR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LINC01006 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-AA76LMBR1chr7

156549087

-LINC01006chr7

156265405

-
ChimerDB4BRCATCGA-AC-A6IX-01ALMBR1chr7

156589083

-LINC01006chr7

156265405

-
ChimerDB4BRCATCGA-AC-A6IX-01ALMBR1chr7

156589083

-LINC01006chr7

156398458

-
ChimerDB4STADTCGA-BR-7716-01ALMBR1chr7

156549087

-LINC01006chr7

156265405

-


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Fusion Gene ORF analysis for LMBR1-LINC01006

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000353442ENST00000447933LMBR1chr7

156549087

-LINC01006chr7

156265405

-
5CDS-5UTRENST00000353442ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156265405

-
5CDS-5UTRENST00000354505ENST00000447933LMBR1chr7

156549087

-LINC01006chr7

156265405

-
5CDS-5UTRENST00000354505ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156265405

-
5CDS-5UTRENST00000359422ENST00000447933LMBR1chr7

156549087

-LINC01006chr7

156265405

-
5CDS-5UTRENST00000540390ENST00000447933LMBR1chr7

156549087

-LINC01006chr7

156265405

-
5CDS-5UTRENST00000540390ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156265405

-
5UTR-3CDSENST00000359422ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156398458

-
5UTR-5UTRENST00000359422ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156265405

-
In-frameENST00000353442ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156398458

-
In-frameENST00000354505ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156398458

-
In-frameENST00000540390ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156398458

-
intron-3CDSENST00000430825ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156398458

-
intron-5UTRENST00000430825ENST00000447933LMBR1chr7

156549087

-LINC01006chr7

156265405

-
intron-5UTRENST00000430825ENST00000447933LMBR1chr7

156589083

-LINC01006chr7

156265405

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353442LMBR1chr7156589083-ENST00000447933LINC01006chr7156398458-1426660237770177
ENST00000354505LMBR1chr7156589083-ENST00000447933LINC01006chr7156398458-1343577154687177
ENST00000540390LMBR1chr7156589083-ENST00000447933LINC01006chr7156398458-1302536104646180

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353442ENST00000447933LMBR1chr7156589083-LINC01006chr7156398458-0.0334326250.96656734
ENST00000354505ENST00000447933LMBR1chr7156589083-LINC01006chr7156398458-0.0271085440.9728915
ENST00000540390ENST00000447933LMBR1chr7156589083-LINC01006chr7156398458-0.0404014660.95959854

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Fusion Genomic Features for LMBR1-LINC01006


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for LMBR1-LINC01006


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:156549087/chr7:156265405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-5171_19141491.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-51741_62141491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-51784_110141491.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-5181_19141532.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-51841_62141532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-51884_110141532.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517111_131141491.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-51720_40141491.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-51763_83141491.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518111_131141532.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-51820_40141532.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-51863_83141532.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517250_287141491.0Coiled coilOntology_term=ECO:0000255
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518250_287141532.0Coiled coilOntology_term=ECO:0000255
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517132_151141491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517173_187141491.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517209_291141491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517313_339141491.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517361_383141491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517405_426141491.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517448_490141491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518132_151141532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518173_187141532.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518209_291141532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518313_339141532.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518361_383141532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518405_426141532.0Topological domainExtracellular
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518448_490141532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517152_172141491.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517188_208141491.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517292_312141491.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517340_360141491.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517384_404141491.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000353442-517427_447141491.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518152_172141532.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518188_208141532.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518292_312141532.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518340_360141532.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518384_404141532.0TransmembraneHelical
HgeneLMBR1chr7:156589083chr7:156398458ENST00000354505-518427_447141532.0TransmembraneHelical


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Fusion Gene Sequence for LMBR1-LINC01006


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45736_45736_1_LMBR1-LINC01006_LMBR1_chr7_156589083_ENST00000353442_LINC01006_chr7_156398458_ENST00000447933_length(transcript)=1426nt_BP=660nt
GCCCCGCCCCCGCCCCGCCCCCGACTGCGCGGCGCCCGCCCTCCCTTAGTCAGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTG
TCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGG
ACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAG
CAGCACTTCCACAGCCAAGTGCGGGAGTCCACGATATGTTTCCTTCTTTTTGCCATTCTCTACGTTGTTTCCTACTTCATCATCACAAGA
TACAAGAGAAAATCAGATGAACAAGAAGATGAAGATGCCATCGTCAACAGGATTTCGTTGTTTTTGAGCACGTTCACTCTCGCAGTGTCA
GCTGGGGCTGTTTTGCTTTTACCCTTCTCAATCATCAGCAATGAAATCCTGCTTTCTTTTCCTCAGAACTACTATATTCAGTGGCTAAAT
GGCTCCCTGATTCATGGTTTGTGGAATCTTGCTTCCCTTTTTTCCAACCTTTGTTTATTTGTATTGATGCCCTTTGCCTTTTTCTTTCTG
GAATCAGAAGGCTTTGCTGGCCTGAAAAAGGCCCTCCTGGTGAGATCCCATCACGTCCCCTGGCCTCCAGTGTCATCTGCTCTGCATGAT
ATCTCCAGGGGGACCTCTCTGCTGGGCTCCAGGCCGCATGGCTGTGGGTGACCAGCATCATGTCCCACCGGGTCCCCTGCAGTCCCAGTG
CACCTGCCTGCTCATCCAGGGACCTGTCCTCACTGCCTGCTGCCTGCACTGTGTGGAAGGACAGAGGCTAAACGACGAAGCCTCGAGCTC
TGGTCTCATGGAAATGGCAGCCTGCCCACCACCCACGCTTGCCCAGCCTTTCTTCACGCAGGAAGAATATTTCTCAGCCCTCCGTTCTCA
AGACAGATGAGTGCTTTAGAAAGAGGACTCTGCAGCGGTGAGGAGGATGGAATGACAGGCAAAGCACGCAGGACCAGGAGATGGCTTCGT
TCCCTCAATCACTCATCCAAAGACGTTTAATGAGCACCTATTGTGTGTCAGGCATTGTACCGGGCAATGGGGATATCGTAGTCAGTAATA
AGTGAGGAGAGATGAGTTCATTTGTGAGAGGCTCTGACCAGTGGAATCAGAGGAAGGGAGTTCCCCTGGGTGGGCCAGGTTCAAAGACAT
TTTGGAAGTAGAATCTGCAGAACATGATGATCTTTTGGAAACAGGGCAGGGACGTGAATGAGCACGTAATGTCCCCATGGGTTTGTCTTT

>45736_45736_1_LMBR1-LINC01006_LMBR1_chr7_156589083_ENST00000353442_LINC01006_chr7_156398458_ENST00000447933_length(amino acids)=177AA_BP=0
MEGQDEVSAREQHFHSQVRESTICFLLFAILYVVSYFIITRYKRKSDEQEDEDAIVNRISLFLSTFTLAVSAGAVLLLPFSIISNEILLS

--------------------------------------------------------------
>45736_45736_2_LMBR1-LINC01006_LMBR1_chr7_156589083_ENST00000354505_LINC01006_chr7_156398458_ENST00000447933_length(transcript)=1343nt_BP=577nt
GCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGG
CGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGC
GCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGATATGTTTCCTTCTTTTTGCCATTCTCTACGTTGTTTCCTACTTCATCAT
CACAAGATACAAGAGAAAATCAGATGAACAAGAAGATGAAGATGCCATCGTCAACAGGATTTCGTTGTTTTTGAGCACGTTCACTCTCGC
AGTGTCAGCTGGGGCTGTTTTGCTTTTACCCTTCTCAATCATCAGCAATGAAATCCTGCTTTCTTTTCCTCAGAACTACTATATTCAGTG
GCTAAATGGCTCCCTGATTCATGGTTTGTGGAATCTTGCTTCCCTTTTTTCCAACCTTTGTTTATTTGTATTGATGCCCTTTGCCTTTTT
CTTTCTGGAATCAGAAGGCTTTGCTGGCCTGAAAAAGGCCCTCCTGGTGAGATCCCATCACGTCCCCTGGCCTCCAGTGTCATCTGCTCT
GCATGATATCTCCAGGGGGACCTCTCTGCTGGGCTCCAGGCCGCATGGCTGTGGGTGACCAGCATCATGTCCCACCGGGTCCCCTGCAGT
CCCAGTGCACCTGCCTGCTCATCCAGGGACCTGTCCTCACTGCCTGCTGCCTGCACTGTGTGGAAGGACAGAGGCTAAACGACGAAGCCT
CGAGCTCTGGTCTCATGGAAATGGCAGCCTGCCCACCACCCACGCTTGCCCAGCCTTTCTTCACGCAGGAAGAATATTTCTCAGCCCTCC
GTTCTCAAGACAGATGAGTGCTTTAGAAAGAGGACTCTGCAGCGGTGAGGAGGATGGAATGACAGGCAAAGCACGCAGGACCAGGAGATG
GCTTCGTTCCCTCAATCACTCATCCAAAGACGTTTAATGAGCACCTATTGTGTGTCAGGCATTGTACCGGGCAATGGGGATATCGTAGTC
AGTAATAAGTGAGGAGAGATGAGTTCATTTGTGAGAGGCTCTGACCAGTGGAATCAGAGGAAGGGAGTTCCCCTGGGTGGGCCAGGTTCA
AAGACATTTTGGAAGTAGAATCTGCAGAACATGATGATCTTTTGGAAACAGGGCAGGGACGTGAATGAGCACGTAATGTCCCCATGGGTT

>45736_45736_2_LMBR1-LINC01006_LMBR1_chr7_156589083_ENST00000354505_LINC01006_chr7_156398458_ENST00000447933_length(amino acids)=177AA_BP=0
MEGQDEVSAREQHFHSQVRESTICFLLFAILYVVSYFIITRYKRKSDEQEDEDAIVNRISLFLSTFTLAVSAGAVLLLPFSIISNEILLS

--------------------------------------------------------------
>45736_45736_3_LMBR1-LINC01006_LMBR1_chr7_156589083_ENST00000540390_LINC01006_chr7_156398458_ENST00000447933_length(transcript)=1302nt_BP=536nt
AGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCC
GGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGA
AGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGATGAACAAGAAGATGAAG
ATGCCATCGTCAACAGGATTTCGTTGTTTTTGAGCACGTTCACTCTCGCAGTGTCAGCTGGGGCTGTTTTGCTTTTACCCTTCTCAATCA
TCAGCAATGAAATCCTGCTTTCTTTTCCTCAGAACTACTATATTCAGTGGCTAAATGGCTCCCTGATTCATGGTTTGTGGAATCTTGCTT
CCCTTTTTTCCAACCTTTGTTTATTTGTATTGATGCCCTTTGCCTTTTTCTTTCTGGAATCAGAAGGCTTTGCTGGCCTGAAAAAGGCCC
TCCTGGTGAGATCCCATCACGTCCCCTGGCCTCCAGTGTCATCTGCTCTGCATGATATCTCCAGGGGGACCTCTCTGCTGGGCTCCAGGC
CGCATGGCTGTGGGTGACCAGCATCATGTCCCACCGGGTCCCCTGCAGTCCCAGTGCACCTGCCTGCTCATCCAGGGACCTGTCCTCACT
GCCTGCTGCCTGCACTGTGTGGAAGGACAGAGGCTAAACGACGAAGCCTCGAGCTCTGGTCTCATGGAAATGGCAGCCTGCCCACCACCC
ACGCTTGCCCAGCCTTTCTTCACGCAGGAAGAATATTTCTCAGCCCTCCGTTCTCAAGACAGATGAGTGCTTTAGAAAGAGGACTCTGCA
GCGGTGAGGAGGATGGAATGACAGGCAAAGCACGCAGGACCAGGAGATGGCTTCGTTCCCTCAATCACTCATCCAAAGACGTTTAATGAG
CACCTATTGTGTGTCAGGCATTGTACCGGGCAATGGGGATATCGTAGTCAGTAATAAGTGAGGAGAGATGAGTTCATTTGTGAGAGGCTC
TGACCAGTGGAATCAGAGGAAGGGAGTTCCCCTGGGTGGGCCAGGTTCAAAGACATTTTGGAAGTAGAATCTGCAGAACATGATGATCTT
TTGGAAACAGGGCAGGGACGTGAATGAGCACGTAATGTCCCCATGGGTTTGTCTTTCCGAAGGTTTAAAATCCTCAAGAATAAGGAACAT

>45736_45736_3_LMBR1-LINC01006_LMBR1_chr7_156589083_ENST00000540390_LINC01006_chr7_156398458_ENST00000447933_length(amino acids)=180AA_BP=1
MSEPLRRADDGVAEHADAGGAAAGMKEDGRAGRGVGAGAALPQPSAGVHDEQEDEDAIVNRISLFLSTFTLAVSAGAVLLLPFSIISNEI
LLSFPQNYYIQWLNGSLIHGLWNLASLFSNLCLFVLMPFAFFFLESEGFAGLKKALLVRSHHVPWPPVSSALHDISRGTSLLGSRPHGCG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LMBR1-LINC01006


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LMBR1-LINC01006


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LMBR1-LINC01006


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLMBR1C1868114POLYDACTYLY, PREAXIAL II (disorder)4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneLMBR1C1851100LAURIN-SANDROW SYNDROME2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneLMBR1C1861355Syndactyly, Type IV2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneLMBR1C0265559Acheiropodia1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneLMBR1C0265581Longitudinal deficiency of radius1ORPHANET
HgeneLMBR1C1861098Tibia, Hypoplasia of, with Polydactyly1GENOMICS_ENGLAND