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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCLRE1C-NMT2 (FusionGDB2 ID:HG64421TG9397)

Fusion Gene Summary for DCLRE1C-NMT2

check button Fusion gene summary
Fusion gene informationFusion gene name: DCLRE1C-NMT2
Fusion gene ID: hg64421tg9397
HgeneTgene
Gene symbol

DCLRE1C

NMT2

Gene ID

64421

9397

Gene nameDNA cross-link repair 1CN-myristoyltransferase 2
SynonymsA-SCID|DCLREC1C|RS-SCID|SCIDA|SNM1C-
Cytomap('DCLRE1C')('NMT2')

10p13

10p13

Type of geneprotein-codingprotein-coding
Descriptionprotein artemisDNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)SNM1 homolog CSNM1-like proteinsevere combined immunodeficiency, type a (Athabascan)glycylpeptide N-tetradecanoyltransferase 2NMT 2glycylpeptide N-tetradecanoyltransferase 2 variant 3glycylpeptide N-tetradecanoyltransferase 2 variant 4myristoyl-CoA:protein N-myristoyltransferase 2peptide N-myristoyltransferase 2type II N-myristoylt
Modification date2020031320200313
UniProtAcc.

O60551

Ensembl transtripts involved in fusion geneENST00000378278, ENST00000378289, 
ENST00000357717, ENST00000378246, 
ENST00000378254, ENST00000378255, 
ENST00000378258, ENST00000396817, 
ENST00000453695, ENST00000378242, 
ENST00000378249, ENST00000492201, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 3 X 4=48
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DCLRE1C [Title/Abstract] AND NMT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCLRE1C(14991035)-NMT2(15170457), # samples:2
Anticipated loss of major functional domain due to fusion event.DCLRE1C-NMT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DCLRE1C-NMT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNMT2

GO:0018008

N-terminal peptidyl-glycine N-myristoylation

25255805


check buttonFusion gene breakpoints across DCLRE1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NMT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3JW-01ADCLRE1Cchr10

14991035

-NMT2chr10

15170457

-


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Fusion Gene ORF analysis for DCLRE1C-NMT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000378278ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5CDS-intronENST00000378278ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5CDS-intronENST00000378289ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5CDS-intronENST00000378289ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000357717ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000357717ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000357717ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378246ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378246ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378246ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378254ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378254ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378254ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378255ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378255ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378255ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378258ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378258ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000378258ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000396817ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000396817ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000396817ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000453695ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000453695ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-3CDSENST00000453695ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000357717ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000357717ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000378246ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000378246ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000378254ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000378254ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000378255ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000378255ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000378258ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000378258ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000396817ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000396817ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000453695ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
5UTR-intronENST00000453695ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
In-frameENST00000378278ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
In-frameENST00000378278ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
In-frameENST00000378278ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
In-frameENST00000378289ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
In-frameENST00000378289ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
In-frameENST00000378289ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-3CDSENST00000378242ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-3CDSENST00000378242ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-3CDSENST00000378242ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-3CDSENST00000378249ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-3CDSENST00000378249ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-3CDSENST00000378249ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-3CDSENST00000492201ENST00000378150DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-3CDSENST00000492201ENST00000378165DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-3CDSENST00000492201ENST00000535341DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-intronENST00000378242ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-intronENST00000378242ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-intronENST00000378249ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-intronENST00000378249ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-intronENST00000492201ENST00000466201DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-
intron-intronENST00000492201ENST00000540259DCLRE1Cchr10

14991035

-NMT2chr10

15170457

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000378289DCLRE1Cchr1014991035-ENST00000378165NMT2chr1015170457-25195833021189295
ENST00000378289DCLRE1Cchr1014991035-ENST00000378150NMT2chr1015170457-20915833021189295
ENST00000378289DCLRE1Cchr1014991035-ENST00000535341NMT2chr1015170457-12865833021189295
ENST00000378278DCLRE1Cchr1014991035-ENST00000378165NMT2chr1015170457-213519938805255
ENST00000378278DCLRE1Cchr1014991035-ENST00000378150NMT2chr1015170457-170719938805255
ENST00000378278DCLRE1Cchr1014991035-ENST00000535341NMT2chr1015170457-90219938805255

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378289ENST00000378165DCLRE1Cchr1014991035-NMT2chr1015170457-0.0021614210.99783856
ENST00000378289ENST00000378150DCLRE1Cchr1014991035-NMT2chr1015170457-0.0031590760.99684095
ENST00000378289ENST00000535341DCLRE1Cchr1014991035-NMT2chr1015170457-0.007428450.99257153
ENST00000378278ENST00000378165DCLRE1Cchr1014991035-NMT2chr1015170457-0.0015839550.99841607
ENST00000378278ENST00000378150DCLRE1Cchr1014991035-NMT2chr1015170457-0.0018675270.9981325
ENST00000378278ENST00000535341DCLRE1Cchr1014991035-NMT2chr1015170457-0.0050557320.9949443

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Fusion Genomic Features for DCLRE1C-NMT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DCLRE1C-NMT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:14991035/chr10:15170457)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NMT2

O60551

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. {ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9506952}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNMT2chr10:14991035chr10:15170457ENST0000037816561246_56296499.0Compositional biasNote=Poly-Lys
TgeneNMT2chr10:14991035chr10:15170457ENST00000378165612120_122296499.0RegionMyristoyl-CoA binding
TgeneNMT2chr10:14991035chr10:15170457ENST00000378165612250_252296499.0RegionMyristoyl-CoA binding
TgeneNMT2chr10:14991035chr10:15170457ENST00000378165612258_262296499.0RegionMyristoyl-CoA binding


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Fusion Gene Sequence for DCLRE1C-NMT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21629_21629_1_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378278_NMT2_chr10_15170457_ENST00000378150_length(transcript)=1707nt_BP=199nt
GCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCGCTATGAGTTCTTTCGAGGGGCAGATGGCCGAGTATCCAACTATCTCCATAGACC
GCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTCCCACTGCCACAAAGATCACATGAAAGGATTAAGAGCCCCTACCTTGA
AAAGAAGGTTGGAGTGCAGATACTGGCATCGATCACTAAACCCCAGAAAATTGGTAGAAGTGAAATTTTCTCACTTGAGTAGAAATATGA
CTTTACAGAGAACAATGAAGCTATACAGACTTCCAGATGTTACAAAGACTTCAGGTTTGAGACCAATGGAACCAAAAGATATCAAATCAG
TTCGAGAATTAATCAACACTTACCTGAAGCAGTTTCATCTGGCTCCAGTGATGGATGAAGAGGAAGTAGCCCACTGGTTCCTCCCCCGGG
AGCACATTATTGACACGTTTGTAGTGGAGAGCCCCAACGGTAAACTGACTGATTTCCTGAGCTTCTATACGCTCCCCTCCACGGTGATGC
ACCACCCTGCTCACAAGAGCCTCAAAGCCGCCTACTCATTCTACAACATCCACACAGAGACGCCCCTGCTGGACCTCATGAGCGACGCGC
TCATCCTGGCTAAATCGAAAGGATTTGATGTATTCAATGCACTGGATTTGATGGAAAATAAGACATTCTTGGAAAAACTCAAGTTTGGTA
TAGGAGATGGCAATTTGCAGTATTACCTGTACAATTGGAGGTGTCCAGGTACAGATTCTGAAAAGGTTGGACTAGTACTACAATAGATGG
ATATTTTTATTTCTAGAACTCTGACATCATCATTTGTTAATATTTAATGATTTCTGGAACTGCCATTCCAAAGAAGAATAAAAGCACAAC
TCAAGTGAAATTGAAGTAGTCGATAATCAGAAAAGATGACAAAAGTCCACATGTGACATTTGTACGTTTCTAGCTAGAATGTTAAACTTC
ATCCTTTTTTTACTGTTGACCTATTTGTGGGAGGGATGAAAGGCTACAAAGAGCACATTCTTGTAATTTTCAAATTTTTGCCTGTCTCTT
GAAGAGGTATTTTTTCACCCTTAGAAAAGGGACTGTTTTTCTATGGACTAAGTAGAAGTTACAGAGTCATGTAAGAAAATCTTTGCTATT
GTGTGGAGAGAAATTGCTGCATTTCTGTTTCTTAAGTGATGGTACATTTGTCCATGTAACAGAACAAAAGATCCATTTGGAAATTTTTTT
TACTGGTATCACCTTACATGGTATCACTGGGAACATTTATGGAATCAACACTTCTGTAGCTCAGTGACAGGTGGTGGTTGTTTAAGTGCA
GAGCAATATTAAAATGTACTGGTGACTAGTACATGTATTTCTCCATAAGCAGAGTTGCCGAATCAATAAACATGCAAGTTTGTACTTTGA
TCTTTACCAGGTCAGTGGATTGCTTCAAAAGCAGAGTTTTGTGCAAGCACTCACTGTGCTCTCTGAAAGAGCCTGAGGCCGGGCGTGGTG
GCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCATGAGGTCAGGAGATCGAGACCATTCTGGCCAACATAGTGAA

>21629_21629_1_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378278_NMT2_chr10_15170457_ENST00000378150_length(amino acids)=255AA_BP=46
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPD
VTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYS

--------------------------------------------------------------
>21629_21629_2_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378278_NMT2_chr10_15170457_ENST00000378165_length(transcript)=2135nt_BP=199nt
GCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCGCTATGAGTTCTTTCGAGGGGCAGATGGCCGAGTATCCAACTATCTCCATAGACC
GCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTCCCACTGCCACAAAGATCACATGAAAGGATTAAGAGCCCCTACCTTGA
AAAGAAGGTTGGAGTGCAGATACTGGCATCGATCACTAAACCCCAGAAAATTGGTAGAAGTGAAATTTTCTCACTTGAGTAGAAATATGA
CTTTACAGAGAACAATGAAGCTATACAGACTTCCAGATGTTACAAAGACTTCAGGTTTGAGACCAATGGAACCAAAAGATATCAAATCAG
TTCGAGAATTAATCAACACTTACCTGAAGCAGTTTCATCTGGCTCCAGTGATGGATGAAGAGGAAGTAGCCCACTGGTTCCTCCCCCGGG
AGCACATTATTGACACGTTTGTAGTGGAGAGCCCCAACGGTAAACTGACTGATTTCCTGAGCTTCTATACGCTCCCCTCCACGGTGATGC
ACCACCCTGCTCACAAGAGCCTCAAAGCCGCCTACTCATTCTACAACATCCACACAGAGACGCCCCTGCTGGACCTCATGAGCGACGCGC
TCATCCTGGCTAAATCGAAAGGATTTGATGTATTCAATGCACTGGATTTGATGGAAAATAAGACATTCTTGGAAAAACTCAAGTTTGGTA
TAGGAGATGGCAATTTGCAGTATTACCTGTACAATTGGAGGTGTCCAGGTACAGATTCTGAAAAGGTTGGACTAGTACTACAATAGATGG
ATATTTTTATTTCTAGAACTCTGACATCATCATTTGTTAATATTTAATGATTTCTGGAACTGCCATTCCAAAGAAGAATAAAAGCACAAC
TCAAGTGAAATTGAAGTAGTCGATAATCAGAAAAGATGACAAAAGTCCACATGTGACATTTGTACGTTTCTAGCTAGAATGTTAAACTTC
ATCCTTTTTTTACTGTTGACCTATTTGTGGGAGGGATGAAAGGCTACAAAGAGCACATTCTTGTAATTTTCAAATTTTTGCCTGTCTCTT
GAAGAGGTATTTTTTCACCCTTAGAAAAGGGACTGTTTTTCTATGGACTAAGTAGAAGTTACAGAGTCATGTAAGAAAATCTTTGCTATT
GTGTGGAGAGAAATTGCTGCATTTCTGTTTCTTAAGTGATGGTACATTTGTCCATGTAACAGAACAAAAGATCCATTTGGAAATTTTTTT
TACTGGTATCACCTTACATGGTATCACTGGGAACATTTATGGAATCAACACTTCTGTAGCTCAGTGACAGGTGGTGGTTGTTTAAGTGCA
GAGCAATATTAAAATGTACTGGTGACTAGTACATGTATTTCTCCATAAGCAGAGTTGCCGAATCAATAAACATGCAAGTTTGTACTTTGA
TCTTTACCAGGTCAGTGGATTGCTTCAAAAGCAGAGTTTTGTGCAAGCACTCACTGTGCTCTCTGAAAGAGCCTGAGGCCGGGCGTGGTG
GCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCATGAGGTCAGGAGATCGAGACCATTCTGGCCAACATAGTGAA
ACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGCGTGTGCCTGTAGTCCCAGCTGCTTGGGAGGCTGAGGCAGGAGAAT
CGCTTGAACCTGAGAGGTGAGGTTGCAGTGAGCCGAGATCGAGCCACTGCACTCCAGCCTGGGTGACAGAGCGTGAGACTCCGTCTCAAA
AAAAAAAAAAAAGAAAGAGCCTGTACCCGCGACTAACTAGACTTTTCTGCTGTTGTGCAAAGTTCAGTTTCTTCTCAGCAACATCAAGGA
TATATGAAGAAAAGGAAATAAAAAACTGTAAAGTCAAAAGAGATGCCTGGTGGAACTTATTCGTGCTATCAGGGCATTGATAGTTTGAAT
GTTTTTATTACTTATGCAAAATTGCACATACTCCTCTATGCTGATTTTATCATGAAAACTGTCATGTGTCATGCTAATGGAAAATGTCTT

>21629_21629_2_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378278_NMT2_chr10_15170457_ENST00000378165_length(amino acids)=255AA_BP=46
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPD
VTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYS

--------------------------------------------------------------
>21629_21629_3_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378278_NMT2_chr10_15170457_ENST00000535341_length(transcript)=902nt_BP=199nt
GCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCGCTATGAGTTCTTTCGAGGGGCAGATGGCCGAGTATCCAACTATCTCCATAGACC
GCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTCCCACTGCCACAAAGATCACATGAAAGGATTAAGAGCCCCTACCTTGA
AAAGAAGGTTGGAGTGCAGATACTGGCATCGATCACTAAACCCCAGAAAATTGGTAGAAGTGAAATTTTCTCACTTGAGTAGAAATATGA
CTTTACAGAGAACAATGAAGCTATACAGACTTCCAGATGTTACAAAGACTTCAGGTTTGAGACCAATGGAACCAAAAGATATCAAATCAG
TTCGAGAATTAATCAACACTTACCTGAAGCAGTTTCATCTGGCTCCAGTGATGGATGAAGAGGAAGTAGCCCACTGGTTCCTCCCCCGGG
AGCACATTATTGACACGTTTGTAGTGGAGAGCCCCAACGGTAAACTGACTGATTTCCTGAGCTTCTATACGCTCCCCTCCACGGTGATGC
ACCACCCTGCTCACAAGAGCCTCAAAGCCGCCTACTCATTCTACAACATCCACACAGAGACGCCCCTGCTGGACCTCATGAGCGACGCGC
TCATCCTGGCTAAATCGAAAGGATTTGATGTATTCAATGCACTGGATTTGATGGAAAATAAGACATTCTTGGAAAAACTCAAGTTTGGTA
TAGGAGATGGCAATTTGCAGTATTACCTGTACAATTGGAGGTGTCCAGGTACAGATTCTGAAAAGGTTGGACTAGTACTACAATAGATGG
ATATTTTTATTTCTAGAACTCTGACATCATCATTTGTTAATATTTAATGATTTCTGGAACTGCCATTCCAAAGAAGAATAAAAGCACAAC

>21629_21629_3_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378278_NMT2_chr10_15170457_ENST00000535341_length(amino acids)=255AA_BP=46
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPD
VTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYS

--------------------------------------------------------------
>21629_21629_4_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378289_NMT2_chr10_15170457_ENST00000378150_length(transcript)=2091nt_BP=583nt
CGGAACGAAGAATGATTTCTAAGCGCAGTTCCGCAGCCCACTCACCTCGTCGGCTGGGGCCACCTGCTCTGGGAGTTTCGATTTCCCTTC
CCGCGACTGCACCTCCACAGACATGGGCAACGCCTTACCAGAGCAACACCTGTGTTTGTTGGGCGGGAATGAGCCTTGCACTGGGCAGGG
CTCAGGGCCCATCGCGTGCAGCGAAGCGCGGGTGATTTAAACCCAAGCAGCGGGCGCCTAGAACCCGACCGGATGCTCCTTGACTTTGCC
CCCGGTCTCCGGACTCCTCTGATTGGACGTGGCTGCGTTCGGCCGCCCAATGGCGAGGCAGCGCGCGGCTTCCCGGAAGTGGCGGCGCGG
TCAGGGCTGGCCTTGGCTTCAGCTGCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCGCTATGAGTTCTTTCGAGGGGCAGATGGCCG
AGTATCCAACTATCTCCATAGACCGCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTCCCACTGCCACAAAGATCACATGA
AAGGATTAAGAGCCCCTACCTTGAAAAGAAGGTTGGAGTGCAGATACTGGCATCGATCACTAAACCCCAGAAAATTGGTAGAAGTGAAAT
TTTCTCACTTGAGTAGAAATATGACTTTACAGAGAACAATGAAGCTATACAGACTTCCAGATGTTACAAAGACTTCAGGTTTGAGACCAA
TGGAACCAAAAGATATCAAATCAGTTCGAGAATTAATCAACACTTACCTGAAGCAGTTTCATCTGGCTCCAGTGATGGATGAAGAGGAAG
TAGCCCACTGGTTCCTCCCCCGGGAGCACATTATTGACACGTTTGTAGTGGAGAGCCCCAACGGTAAACTGACTGATTTCCTGAGCTTCT
ATACGCTCCCCTCCACGGTGATGCACCACCCTGCTCACAAGAGCCTCAAAGCCGCCTACTCATTCTACAACATCCACACAGAGACGCCCC
TGCTGGACCTCATGAGCGACGCGCTCATCCTGGCTAAATCGAAAGGATTTGATGTATTCAATGCACTGGATTTGATGGAAAATAAGACAT
TCTTGGAAAAACTCAAGTTTGGTATAGGAGATGGCAATTTGCAGTATTACCTGTACAATTGGAGGTGTCCAGGTACAGATTCTGAAAAGG
TTGGACTAGTACTACAATAGATGGATATTTTTATTTCTAGAACTCTGACATCATCATTTGTTAATATTTAATGATTTCTGGAACTGCCAT
TCCAAAGAAGAATAAAAGCACAACTCAAGTGAAATTGAAGTAGTCGATAATCAGAAAAGATGACAAAAGTCCACATGTGACATTTGTACG
TTTCTAGCTAGAATGTTAAACTTCATCCTTTTTTTACTGTTGACCTATTTGTGGGAGGGATGAAAGGCTACAAAGAGCACATTCTTGTAA
TTTTCAAATTTTTGCCTGTCTCTTGAAGAGGTATTTTTTCACCCTTAGAAAAGGGACTGTTTTTCTATGGACTAAGTAGAAGTTACAGAG
TCATGTAAGAAAATCTTTGCTATTGTGTGGAGAGAAATTGCTGCATTTCTGTTTCTTAAGTGATGGTACATTTGTCCATGTAACAGAACA
AAAGATCCATTTGGAAATTTTTTTTACTGGTATCACCTTACATGGTATCACTGGGAACATTTATGGAATCAACACTTCTGTAGCTCAGTG
ACAGGTGGTGGTTGTTTAAGTGCAGAGCAATATTAAAATGTACTGGTGACTAGTACATGTATTTCTCCATAAGCAGAGTTGCCGAATCAA
TAAACATGCAAGTTTGTACTTTGATCTTTACCAGGTCAGTGGATTGCTTCAAAAGCAGAGTTTTGTGCAAGCACTCACTGTGCTCTCTGA
AAGAGCCTGAGGCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCATGAGGTCAGGAGATCGA
GACCATTCTGGCCAACATAGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGCGTGTGCCTGTAGTCCCAGCTG

>21629_21629_4_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378289_NMT2_chr10_15170457_ENST00000378150_length(amino acids)=295AA_BP=86
MRSAAQWRGSARLPGSGGAVRAGLGFSCGFGVPDSGIGGAMSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRR
LECRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHI
IDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGD

--------------------------------------------------------------
>21629_21629_5_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378289_NMT2_chr10_15170457_ENST00000378165_length(transcript)=2519nt_BP=583nt
CGGAACGAAGAATGATTTCTAAGCGCAGTTCCGCAGCCCACTCACCTCGTCGGCTGGGGCCACCTGCTCTGGGAGTTTCGATTTCCCTTC
CCGCGACTGCACCTCCACAGACATGGGCAACGCCTTACCAGAGCAACACCTGTGTTTGTTGGGCGGGAATGAGCCTTGCACTGGGCAGGG
CTCAGGGCCCATCGCGTGCAGCGAAGCGCGGGTGATTTAAACCCAAGCAGCGGGCGCCTAGAACCCGACCGGATGCTCCTTGACTTTGCC
CCCGGTCTCCGGACTCCTCTGATTGGACGTGGCTGCGTTCGGCCGCCCAATGGCGAGGCAGCGCGCGGCTTCCCGGAAGTGGCGGCGCGG
TCAGGGCTGGCCTTGGCTTCAGCTGCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCGCTATGAGTTCTTTCGAGGGGCAGATGGCCG
AGTATCCAACTATCTCCATAGACCGCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTCCCACTGCCACAAAGATCACATGA
AAGGATTAAGAGCCCCTACCTTGAAAAGAAGGTTGGAGTGCAGATACTGGCATCGATCACTAAACCCCAGAAAATTGGTAGAAGTGAAAT
TTTCTCACTTGAGTAGAAATATGACTTTACAGAGAACAATGAAGCTATACAGACTTCCAGATGTTACAAAGACTTCAGGTTTGAGACCAA
TGGAACCAAAAGATATCAAATCAGTTCGAGAATTAATCAACACTTACCTGAAGCAGTTTCATCTGGCTCCAGTGATGGATGAAGAGGAAG
TAGCCCACTGGTTCCTCCCCCGGGAGCACATTATTGACACGTTTGTAGTGGAGAGCCCCAACGGTAAACTGACTGATTTCCTGAGCTTCT
ATACGCTCCCCTCCACGGTGATGCACCACCCTGCTCACAAGAGCCTCAAAGCCGCCTACTCATTCTACAACATCCACACAGAGACGCCCC
TGCTGGACCTCATGAGCGACGCGCTCATCCTGGCTAAATCGAAAGGATTTGATGTATTCAATGCACTGGATTTGATGGAAAATAAGACAT
TCTTGGAAAAACTCAAGTTTGGTATAGGAGATGGCAATTTGCAGTATTACCTGTACAATTGGAGGTGTCCAGGTACAGATTCTGAAAAGG
TTGGACTAGTACTACAATAGATGGATATTTTTATTTCTAGAACTCTGACATCATCATTTGTTAATATTTAATGATTTCTGGAACTGCCAT
TCCAAAGAAGAATAAAAGCACAACTCAAGTGAAATTGAAGTAGTCGATAATCAGAAAAGATGACAAAAGTCCACATGTGACATTTGTACG
TTTCTAGCTAGAATGTTAAACTTCATCCTTTTTTTACTGTTGACCTATTTGTGGGAGGGATGAAAGGCTACAAAGAGCACATTCTTGTAA
TTTTCAAATTTTTGCCTGTCTCTTGAAGAGGTATTTTTTCACCCTTAGAAAAGGGACTGTTTTTCTATGGACTAAGTAGAAGTTACAGAG
TCATGTAAGAAAATCTTTGCTATTGTGTGGAGAGAAATTGCTGCATTTCTGTTTCTTAAGTGATGGTACATTTGTCCATGTAACAGAACA
AAAGATCCATTTGGAAATTTTTTTTACTGGTATCACCTTACATGGTATCACTGGGAACATTTATGGAATCAACACTTCTGTAGCTCAGTG
ACAGGTGGTGGTTGTTTAAGTGCAGAGCAATATTAAAATGTACTGGTGACTAGTACATGTATTTCTCCATAAGCAGAGTTGCCGAATCAA
TAAACATGCAAGTTTGTACTTTGATCTTTACCAGGTCAGTGGATTGCTTCAAAAGCAGAGTTTTGTGCAAGCACTCACTGTGCTCTCTGA
AAGAGCCTGAGGCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCATGAGGTCAGGAGATCGA
GACCATTCTGGCCAACATAGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGCGTGTGCCTGTAGTCCCAGCTG
CTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGAGAGGTGAGGTTGCAGTGAGCCGAGATCGAGCCACTGCACTCCAGCCTGGGTGA
CAGAGCGTGAGACTCCGTCTCAAAAAAAAAAAAAAAGAAAGAGCCTGTACCCGCGACTAACTAGACTTTTCTGCTGTTGTGCAAAGTTCA
GTTTCTTCTCAGCAACATCAAGGATATATGAAGAAAAGGAAATAAAAAACTGTAAAGTCAAAAGAGATGCCTGGTGGAACTTATTCGTGC
TATCAGGGCATTGATAGTTTGAATGTTTTTATTACTTATGCAAAATTGCACATACTCCTCTATGCTGATTTTATCATGAAAACTGTCATG

>21629_21629_5_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378289_NMT2_chr10_15170457_ENST00000378165_length(amino acids)=295AA_BP=86
MRSAAQWRGSARLPGSGGAVRAGLGFSCGFGVPDSGIGGAMSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRR
LECRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHI
IDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGD

--------------------------------------------------------------
>21629_21629_6_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378289_NMT2_chr10_15170457_ENST00000535341_length(transcript)=1286nt_BP=583nt
CGGAACGAAGAATGATTTCTAAGCGCAGTTCCGCAGCCCACTCACCTCGTCGGCTGGGGCCACCTGCTCTGGGAGTTTCGATTTCCCTTC
CCGCGACTGCACCTCCACAGACATGGGCAACGCCTTACCAGAGCAACACCTGTGTTTGTTGGGCGGGAATGAGCCTTGCACTGGGCAGGG
CTCAGGGCCCATCGCGTGCAGCGAAGCGCGGGTGATTTAAACCCAAGCAGCGGGCGCCTAGAACCCGACCGGATGCTCCTTGACTTTGCC
CCCGGTCTCCGGACTCCTCTGATTGGACGTGGCTGCGTTCGGCCGCCCAATGGCGAGGCAGCGCGCGGCTTCCCGGAAGTGGCGGCGCGG
TCAGGGCTGGCCTTGGCTTCAGCTGCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCGCTATGAGTTCTTTCGAGGGGCAGATGGCCG
AGTATCCAACTATCTCCATAGACCGCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTCCCACTGCCACAAAGATCACATGA
AAGGATTAAGAGCCCCTACCTTGAAAAGAAGGTTGGAGTGCAGATACTGGCATCGATCACTAAACCCCAGAAAATTGGTAGAAGTGAAAT
TTTCTCACTTGAGTAGAAATATGACTTTACAGAGAACAATGAAGCTATACAGACTTCCAGATGTTACAAAGACTTCAGGTTTGAGACCAA
TGGAACCAAAAGATATCAAATCAGTTCGAGAATTAATCAACACTTACCTGAAGCAGTTTCATCTGGCTCCAGTGATGGATGAAGAGGAAG
TAGCCCACTGGTTCCTCCCCCGGGAGCACATTATTGACACGTTTGTAGTGGAGAGCCCCAACGGTAAACTGACTGATTTCCTGAGCTTCT
ATACGCTCCCCTCCACGGTGATGCACCACCCTGCTCACAAGAGCCTCAAAGCCGCCTACTCATTCTACAACATCCACACAGAGACGCCCC
TGCTGGACCTCATGAGCGACGCGCTCATCCTGGCTAAATCGAAAGGATTTGATGTATTCAATGCACTGGATTTGATGGAAAATAAGACAT
TCTTGGAAAAACTCAAGTTTGGTATAGGAGATGGCAATTTGCAGTATTACCTGTACAATTGGAGGTGTCCAGGTACAGATTCTGAAAAGG
TTGGACTAGTACTACAATAGATGGATATTTTTATTTCTAGAACTCTGACATCATCATTTGTTAATATTTAATGATTTCTGGAACTGCCAT

>21629_21629_6_DCLRE1C-NMT2_DCLRE1C_chr10_14991035_ENST00000378289_NMT2_chr10_15170457_ENST00000535341_length(amino acids)=295AA_BP=86
MRSAAQWRGSARLPGSGGAVRAGLGFSCGFGVPDSGIGGAMSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRR
LECRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHI
IDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCLRE1C-NMT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCLRE1C-NMT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCLRE1C-NMT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCLRE1CC1865370Severe combined immunodeficiency with sensitivity to ionizing radiation6CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneDCLRE1CC1865372Athabaskan severe combined immunodeficiency1ORPHANET
HgeneDCLRE1CC2700553Omenn Syndrome1GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0010093Corpus Luteum Cyst1CTD_human
TgeneC0029927Ovarian Cysts1CTD_human