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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATG3-CLTC (FusionGDB2 ID:HG64422TG1213)

Fusion Gene Summary for ATG3-CLTC

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG3-CLTC
Fusion gene ID: hg64422tg1213
HgeneTgene
Gene symbol

ATG3

CLTC

Gene ID

64422

1213

Gene nameautophagy related 3clathrin heavy chain
SynonymsAPG3|APG3-LIKE|APG3L|PC3-96CHC|CHC17|CLH-17|CLTCL2|Hc|MRD56
Cytomap('ATG3')('CLTC')

3q13.2

17q23.1

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-like-conjugating enzyme ATG32610016C12RikAPG3 autophagy 3-likeATG3 autophagy related 3 homologautophagy-related protein 3hApg3clathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2
Modification date2020031320200313
UniProtAcc.

Q00610

Ensembl transtripts involved in fusion geneENST00000283290, ENST00000402314, 
ENST00000495756, 
Fusion gene scores* DoF score5 X 5 X 2=5018 X 18 X 8=2592
# samples 522
** MAII scorelog2(5/50*10)=0log2(22/2592*10)=-3.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG3 [Title/Abstract] AND CLTC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG3(112262904)-CLTC(57767997), # samples:1
Anticipated loss of major functional domain due to fusion event.ATG3-CLTC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG3-CLTC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG3-CLTC seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATG3-CLTC seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ATG3-CLTC seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATG3

GO:0006464

cellular protein modification process

11825910

HgeneATG3

GO:0016567

protein ubiquitination

11825910

TgeneCLTC

GO:1900126

negative regulation of hyaluronan biosynthetic process

24251095


check buttonFusion gene breakpoints across ATG3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLTC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8080-01AATG3chr3

112262904

-CLTCchr17

57767997

+


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Fusion Gene ORF analysis for ATG3-CLTC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000283290ENST00000579815ATG3chr3

112262904

-CLTCchr17

57767997

+
5CDS-intronENST00000402314ENST00000579815ATG3chr3

112262904

-CLTCchr17

57767997

+
5UTR-3CDSENST00000495756ENST00000269122ATG3chr3

112262904

-CLTCchr17

57767997

+
5UTR-3CDSENST00000495756ENST00000393043ATG3chr3

112262904

-CLTCchr17

57767997

+
5UTR-3CDSENST00000495756ENST00000579456ATG3chr3

112262904

-CLTCchr17

57767997

+
5UTR-intronENST00000495756ENST00000579815ATG3chr3

112262904

-CLTCchr17

57767997

+
Frame-shiftENST00000283290ENST00000393043ATG3chr3

112262904

-CLTCchr17

57767997

+
Frame-shiftENST00000402314ENST00000393043ATG3chr3

112262904

-CLTCchr17

57767997

+
In-frameENST00000283290ENST00000269122ATG3chr3

112262904

-CLTCchr17

57767997

+
In-frameENST00000283290ENST00000579456ATG3chr3

112262904

-CLTCchr17

57767997

+
In-frameENST00000402314ENST00000269122ATG3chr3

112262904

-CLTCchr17

57767997

+
In-frameENST00000402314ENST00000579456ATG3chr3

112262904

-CLTCchr17

57767997

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000283290ATG3chr3112262904-ENST00000269122CLTCchr1757767997+34878283631028221
ENST00000283290ATG3chr3112262904-ENST00000579456CLTCchr1757767997+12918283631028221
ENST00000402314ATG3chr3112262904-ENST00000269122CLTCchr1757767997+3440781316981221
ENST00000402314ATG3chr3112262904-ENST00000579456CLTCchr1757767997+1244781316981221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283290ENST00000269122ATG3chr3112262904-CLTCchr1757767997+0.000690110.9993099
ENST00000283290ENST00000579456ATG3chr3112262904-CLTCchr1757767997+0.0023913710.99760866
ENST00000402314ENST00000269122ATG3chr3112262904-CLTCchr1757767997+0.0006412820.9993587
ENST00000402314ENST00000579456ATG3chr3112262904-CLTCchr1757767997+0.0020276430.9979723

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Fusion Genomic Features for ATG3-CLTC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATG3chr3112262903-CLTCchr1757767996+5.95E-050.9999404
ATG3chr3112262903-CLTCchr1757767996+5.95E-050.9999404

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATG3-CLTC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:112262904/chr17:57767997)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLTC

Q00610

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATG3chr3:112262904chr17:57767997ENST00000283290-612166_169131315.0MotifNote=Caspase cleavage motif LETD
HgeneATG3chr3:112262904chr17:57767997ENST00000402314-611166_169131312.0MotifNote=Caspase cleavage motif LETD
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932108_14916091676.0RegionNote=WD40-like repeat 3
TgeneCLTCchr3:112262904chr17:57767997ENST0000026912229321213_152216091676.0RegionInvolved in binding clathrin light chain
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932150_19516091676.0RegionNote=WD40-like repeat 4
TgeneCLTCchr3:112262904chr17:57767997ENST0000026912229321550_167516091676.0RegionTrimerization
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932196_25716091676.0RegionNote=WD40-like repeat 5
TgeneCLTCchr3:112262904chr17:57767997ENST00000269122293224_6716091676.0RegionNote=WD40-like repeat 1
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932258_30116091676.0RegionNote=WD40-like repeat 6
TgeneCLTCchr3:112262904chr17:57767997ENST0000026912229322_47916091676.0RegionNote=Globular terminal domain
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932302_33016091676.0RegionNote=WD40-like repeat 7
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932449_46516091676.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932480_52316091676.0RegionNote=Flexible linker
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932524_167516091676.0RegionNote=Heavy chain arm
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932524_63416091676.0RegionNote=Distal segment
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932639_167516091676.0RegionNote=Proximal segment
TgeneCLTCchr3:112262904chr17:57767997ENST00000269122293268_10716091676.0RegionNote=WD40-like repeat 2
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931108_14916091640.0RegionNote=WD40-like repeat 3
TgeneCLTCchr3:112262904chr17:57767997ENST0000039304329311213_152216091640.0RegionInvolved in binding clathrin light chain
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931150_19516091640.0RegionNote=WD40-like repeat 4
TgeneCLTCchr3:112262904chr17:57767997ENST0000039304329311550_167516091640.0RegionTrimerization
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931196_25716091640.0RegionNote=WD40-like repeat 5
TgeneCLTCchr3:112262904chr17:57767997ENST00000393043293124_6716091640.0RegionNote=WD40-like repeat 1
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931258_30116091640.0RegionNote=WD40-like repeat 6
TgeneCLTCchr3:112262904chr17:57767997ENST0000039304329312_47916091640.0RegionNote=Globular terminal domain
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931302_33016091640.0RegionNote=WD40-like repeat 7
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931449_46516091640.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931480_52316091640.0RegionNote=Flexible linker
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931524_167516091640.0RegionNote=Heavy chain arm
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931524_63416091640.0RegionNote=Distal segment
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931639_167516091640.0RegionNote=Proximal segment
TgeneCLTCchr3:112262904chr17:57767997ENST00000393043293168_10716091640.0RegionNote=WD40-like repeat 2
TgeneCLTCchr3:112262904chr17:57767997ENST0000026912229321128_126916091676.0RepeatCHCR 5
TgeneCLTCchr3:112262904chr17:57767997ENST0000026912229321274_142016091676.0RepeatCHCR 6
TgeneCLTCchr3:112262904chr17:57767997ENST0000026912229321423_156616091676.0RepeatCHCR 7
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932537_68316091676.0RepeatCHCR 1
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932686_82816091676.0RepeatCHCR 2
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932833_97216091676.0RepeatCHCR 3
TgeneCLTCchr3:112262904chr17:57767997ENST000002691222932979_112416091676.0RepeatCHCR 4
TgeneCLTCchr3:112262904chr17:57767997ENST0000039304329311128_126916091640.0RepeatCHCR 5
TgeneCLTCchr3:112262904chr17:57767997ENST0000039304329311274_142016091640.0RepeatCHCR 6
TgeneCLTCchr3:112262904chr17:57767997ENST0000039304329311423_156616091640.0RepeatCHCR 7
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931537_68316091640.0RepeatCHCR 1
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931686_82816091640.0RepeatCHCR 2
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931833_97216091640.0RepeatCHCR 3
TgeneCLTCchr3:112262904chr17:57767997ENST000003930432931979_112416091640.0RepeatCHCR 4


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Fusion Gene Sequence for ATG3-CLTC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7558_7558_1_ATG3-CLTC_ATG3_chr3_112262904_ENST00000283290_CLTC_chr17_57767997_ENST00000269122_length(transcript)=3487nt_BP=828nt
TAGTGTCACGTGAGGCCCCGGTGGCGGCGCAGCTACGGCAAGAGAGTGAGAAGGAAGGGAAGCCGGAAGGGGCGCGAGTGAAGCAAAGCG
AGGACAGACAGCTCGCAGAGGGCGAGGGGTGCGTGTGCGTCCGCTTCTCACCTCAGGTCTCCCTTCGGCCCCGCTGCCCTCCCTCGCGGC
TGGGTGACAGCTGGGTCCGGTCCGTCGCGGGCTGCCTGGGGTGCGAGGATCGCGCACCCCGTCTTCGCGCGCTGTGCCTGCCGCCCCGCC
CCCTCGTCCCGCCCGTCCCGTCGCGTCGCGTCCCGTCCCCTCGGGTGCTGCCAGCCGGGTGCTGATGCGAGTCGGTGGCAGCGAGGACAT
TTTCTGACTCCCTGGCCCCTGACACGGCTGCACTTTCCATCCCGTCGCGGGGCCGGCCGCTACTCCGGCCCCAGGATGCAGAATGTGATT
AATACTGTGAAGGGAAAGGCACTGGAAGTGGCTGAGTACCTGACCCCGGTCCTCAAGGAATCAAAGTTTAAGGAAACAGGTGTAATTACC
CCAGAAGAGTTTGTGGCAGCTGGAGATCACCTAGTCCACCACTGTCCAACATGGCAATGGGCTACAGGGGAAGAATTGAAAGTGAAGGCA
TACCTACCAACAGGCAAACAATTTTTGGTAACCAAAAATGTGCCGTGCTATAAGCGGTGCAAACAGATGGAATATTCAGATGAATTGGAA
GCTATCATTGAAGAAGATGATGGTGATGGCGGATGGGTAGATACATATCACAACACAGGTATTACAGGAATAACGGAAGCCGTTAAAGAG
ATCACACTGGAAAATAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTT
TATGGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGCACCTTTTGGTTATGGTTATACCGCACCACCG
TATGGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGCGCTGATCCTGTAGTCACCTATTTTCGTACTGAAACATCGTCTT
TACCCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTTGTAACCTTTATTTCATGAAGGACTTCTTTTTGTTTCTAACTAT
AAACTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCATTTTAGAATTTATTTTCGAAGGGGAATAGTTTCAATGTTTTATT
CACTTGGGCTTTTTTTCTTCCCCCTCTTTCTTTAAAGAACTGCTCAATATTCAATCTGTTGTGAAGAACCTGATTTGCACTCTGTAGTGT
TTAAAGAAACAAAGAAACTCTAATATTGAATCTCTTAAATTTAGTGTATGTAAACAGCTTACAAATACGTATTGTCTAAATGCATTTAAA
TCTGTTTTATTCAAAGAAAAGCTAAAGCAAAAACACTGGCATATGACCATGCAAGACTGTCAGTGCCAACAAAGACAACACTAATCAGCA
CATCGTACACTGGATTGCAGTGCTTCCCAGATTATTGAAAAATGTTACAGACAACTTGCCTGATTTTTAAATGAGCGTAAAAGGCCCTCT
AACCTATGCAGGTTTCCCCATTATGCATATAGAAAATGCTAGTATGTTTTGCTCACTTCATATGTAACAGGTGCCCTTATGTTGTGCTGT
ATCCTGTGCTTTTTCTGTGGGACCATTCCATTCAGGAGCAAAGAGCACCATGATTCCAATCTTGTGTGTGTTTACTAACCCTTCCCTGAG
GTTTGTGTATGTTGGATATTGTGGTGTTTTAGATCACTGAGTGTACAGAAGAGAGAAATTCAAACAAAATATTGCTGTTCTTCAGTTTTG
TTTGTGGAATTTGAAATTACTCAAATTTAAAATAAATTACTGGACTGTGGAAATAACATAGAATTGAAGTTTTAATTAAATACCACTCAA
ACGAAAAGAACAGTAGTTTTTGTAGTTTTATATTGGATACTGAGGCATTAGGGAGGCATGAAAGGAAGAGGAATGAGGATTGAGACATGT
GAAGACATTGTGCATTATATCAATGTGCATTCCTGTAGTTCATTAACAAGGTACATGCAATAGTCTAAAGAACCAGAGTCACTACTATAG
TGGCTTAACATTTAATCTGTCTCCAATATTTTAACCAAGTGACACCGAGGTTTTTATCGAAGCATTTCACTTAAATGAACAAATCATGGC
TGTTATATTAACTTGAAATAAAATATATTTAAACATGTAGTTAACATGCTCTTTCTCATCATGAATTATAAAGGTGCCCAAATTATGGGT
ATCTTGATTTTTTTCAAAAATTGGTTGTGTGAATCCAGCTCTTGCTTATGGCTGAGAATGTTCCTAAAGTTCATTTCACTATCCCTTAAT
CCTCAATAGCTACACATACCCCCTTGCCTAGTTAGTCTTGCACTGCTTTACAACTCTCTTAGGCAAATTACCTAACATAAGCTCCACAGA
AGAGTTTTTTAAAACTTAAAATCCCTGTCCCACCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGA
TTGCTTGAGGCCAGGAGTTCGAGACAAGCCTGACCAACATGGTGACTCCATCTCTACTAAAAATAAAAAATCAGCCAGGTGTGATGGTGG
ATGCCTATAAGATCCTAGCTGCTACTCAGGAGGCAGGAGGCTGAGGCATGAGAATCACTTGAACCTGTGAGGCAAAGGTTGTAGTGAGCC
AAGATCACGTCACTGCACTCCATCCTGGGTGACAGAATGAGACTCTTGTCTCAAAAAACAAAAAAACCTATTTAGTTTCATCCAGGACAT
TAAGTGAAAGTGTTTAATGTGAGTGCAGGTCAGTGAAGAATACAATGGTGCCCCTGCTTTGATTTGTGGGAGGTGCCATCAGTTTTCCCC
ACCACTGCTTTTGCACCCTCAGTGCAAATATCAACACAGAGAAAAAAAAAATAATAATAGTATTATGAAAACATTGACTCTGTGGAGACC
CTGTGGGTTCTGCAGAGTATACTTTGAAAACTATAAGATTATGAGTTCTATAAAATACCAAGTACAGATGAACTAGAAAACAAGCATATA
TCCACAATTACCAGAATTTTCATAGTATTCCTTTTAGTAGATATGCCATGACAGTTACTTAGCCACCCCATGCCATCCTGTTGGGAATGC
CACTACCTTTGAATTTGGAGCCATCAGTCTATCTGAGGCAAACCTCAGAAATTACCTGAGCCAGAATCATGCACTTAGCACTGAGTTCAA
CTCAGTCTTAACGTTGCATTTTGTTGCATCACTTTTGCAGCCAGTAAACATTCTGTTTAGAAATAGTTGCTATTGTGGCATCATTCACAG

>7558_7558_1_ATG3-CLTC_ATG3_chr3_112262904_ENST00000283290_CLTC_chr17_57767997_ENST00000269122_length(amino acids)=221AA_BP=155
MTPWPLTRLHFPSRRGAGRYSGPRMQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAY
LPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKVDKLDASESLRKEEEQATETQPIVY

--------------------------------------------------------------
>7558_7558_2_ATG3-CLTC_ATG3_chr3_112262904_ENST00000283290_CLTC_chr17_57767997_ENST00000579456_length(transcript)=1291nt_BP=828nt
TAGTGTCACGTGAGGCCCCGGTGGCGGCGCAGCTACGGCAAGAGAGTGAGAAGGAAGGGAAGCCGGAAGGGGCGCGAGTGAAGCAAAGCG
AGGACAGACAGCTCGCAGAGGGCGAGGGGTGCGTGTGCGTCCGCTTCTCACCTCAGGTCTCCCTTCGGCCCCGCTGCCCTCCCTCGCGGC
TGGGTGACAGCTGGGTCCGGTCCGTCGCGGGCTGCCTGGGGTGCGAGGATCGCGCACCCCGTCTTCGCGCGCTGTGCCTGCCGCCCCGCC
CCCTCGTCCCGCCCGTCCCGTCGCGTCGCGTCCCGTCCCCTCGGGTGCTGCCAGCCGGGTGCTGATGCGAGTCGGTGGCAGCGAGGACAT
TTTCTGACTCCCTGGCCCCTGACACGGCTGCACTTTCCATCCCGTCGCGGGGCCGGCCGCTACTCCGGCCCCAGGATGCAGAATGTGATT
AATACTGTGAAGGGAAAGGCACTGGAAGTGGCTGAGTACCTGACCCCGGTCCTCAAGGAATCAAAGTTTAAGGAAACAGGTGTAATTACC
CCAGAAGAGTTTGTGGCAGCTGGAGATCACCTAGTCCACCACTGTCCAACATGGCAATGGGCTACAGGGGAAGAATTGAAAGTGAAGGCA
TACCTACCAACAGGCAAACAATTTTTGGTAACCAAAAATGTGCCGTGCTATAAGCGGTGCAAACAGATGGAATATTCAGATGAATTGGAA
GCTATCATTGAAGAAGATGATGGTGATGGCGGATGGGTAGATACATATCACAACACAGGTATTACAGGAATAACGGAAGCCGTTAAAGAG
ATCACACTGGAAAATAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTT
TATGGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGCACCTTTTGGTTATGGTTATACCGCACCACCG
TATGGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGCGCTGATCCTGTAGTCACCTATTTTCGTACTGAAACATCGTCTT
TACCCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTTGTAACCTTTATTTCATGAAGGACTTCTTTTTGTTTCTAACTAT
AAACTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCATTTTAGAATTTATTTTCGAAGGGGAATAGTTTCAATGTTTTATT

>7558_7558_2_ATG3-CLTC_ATG3_chr3_112262904_ENST00000283290_CLTC_chr17_57767997_ENST00000579456_length(amino acids)=221AA_BP=155
MTPWPLTRLHFPSRRGAGRYSGPRMQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAY
LPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKVDKLDASESLRKEEEQATETQPIVY

--------------------------------------------------------------
>7558_7558_3_ATG3-CLTC_ATG3_chr3_112262904_ENST00000402314_CLTC_chr17_57767997_ENST00000269122_length(transcript)=3440nt_BP=781nt
GAGAAGGAAGGGAAGCCGGAAGGGGCGCGAGTGAAGCAAAGCGAGGACAGACAGCTCGCAGAGGGCGAGGGGTGCGTGTGCGTCCGCTTC
TCACCTCAGGTCTCCCTTCGGCCCCGCTGCCCTCCCTCGCGGCTGGGTGACAGCTGGGTCCGGTCCGTCGCGGGCTGCCTGGGGTGCGAG
GATCGCGCACCCCGTCTTCGCGCGCTGTGCCTGCCGCCCCGCCCCCTCGTCCCGCCCGTCCCGTCGCGTCGCGTCCCGTCCCCTCGGGTG
CTGCCAGCCGGGTGCTGATGCGAGTCGGTGGCAGCGAGGACATTTTCTGACTCCCTGGCCCCTGACACGGCTGCACTTTCCATCCCGTCG
CGGGGCCGGCCGCTACTCCGGCCCCAGGATGCAGAATGTGATTAATACTGTGAAGGGAAAGGCACTGGAAGTGGCTGAGTACCTGACCCC
GGTCCTCAAGGAATCAAAGTTTAAGGAAACAGGTGTAATTACCCCAGAAGAGTTTGTGGCAGCTGGAGATCACCTAGTCCACCACTGTCC
AACATGGCAATGGGCTACAGGGGAAGAATTGAAAGTGAAGGCATACCTACCAACAGGCAAACAATTTTTGGTAACCAAAAATGTGCCGTG
CTATAAGCGGTGCAAACAGATGGAATATTCAGATGAATTGGAAGCTATCATTGAAGAAGATGATGGTGATGGCGGATGGGTAGATACATA
TCACAACACAGGTATTACAGGAATAACGGAAGCCGTTAAAGAGATCACACTGGAAAATAAGGTGGATAAATTAGATGCTTCAGAATCACT
GAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTATGGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGT
CCCTCCCCAGGCACCTTTTGGTTATGGTTATACCGCACCACCGTATGGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGC
GCTGATCCTGTAGTCACCTATTTTCGTACTGAAACATCGTCTTTACCCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTT
GTAACCTTTATTTCATGAAGGACTTCTTTTTGTTTCTAACTATAAACTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCAT
TTTAGAATTTATTTTCGAAGGGGAATAGTTTCAATGTTTTATTCACTTGGGCTTTTTTTCTTCCCCCTCTTTCTTTAAAGAACTGCTCAA
TATTCAATCTGTTGTGAAGAACCTGATTTGCACTCTGTAGTGTTTAAAGAAACAAAGAAACTCTAATATTGAATCTCTTAAATTTAGTGT
ATGTAAACAGCTTACAAATACGTATTGTCTAAATGCATTTAAATCTGTTTTATTCAAAGAAAAGCTAAAGCAAAAACACTGGCATATGAC
CATGCAAGACTGTCAGTGCCAACAAAGACAACACTAATCAGCACATCGTACACTGGATTGCAGTGCTTCCCAGATTATTGAAAAATGTTA
CAGACAACTTGCCTGATTTTTAAATGAGCGTAAAAGGCCCTCTAACCTATGCAGGTTTCCCCATTATGCATATAGAAAATGCTAGTATGT
TTTGCTCACTTCATATGTAACAGGTGCCCTTATGTTGTGCTGTATCCTGTGCTTTTTCTGTGGGACCATTCCATTCAGGAGCAAAGAGCA
CCATGATTCCAATCTTGTGTGTGTTTACTAACCCTTCCCTGAGGTTTGTGTATGTTGGATATTGTGGTGTTTTAGATCACTGAGTGTACA
GAAGAGAGAAATTCAAACAAAATATTGCTGTTCTTCAGTTTTGTTTGTGGAATTTGAAATTACTCAAATTTAAAATAAATTACTGGACTG
TGGAAATAACATAGAATTGAAGTTTTAATTAAATACCACTCAAACGAAAAGAACAGTAGTTTTTGTAGTTTTATATTGGATACTGAGGCA
TTAGGGAGGCATGAAAGGAAGAGGAATGAGGATTGAGACATGTGAAGACATTGTGCATTATATCAATGTGCATTCCTGTAGTTCATTAAC
AAGGTACATGCAATAGTCTAAAGAACCAGAGTCACTACTATAGTGGCTTAACATTTAATCTGTCTCCAATATTTTAACCAAGTGACACCG
AGGTTTTTATCGAAGCATTTCACTTAAATGAACAAATCATGGCTGTTATATTAACTTGAAATAAAATATATTTAAACATGTAGTTAACAT
GCTCTTTCTCATCATGAATTATAAAGGTGCCCAAATTATGGGTATCTTGATTTTTTTCAAAAATTGGTTGTGTGAATCCAGCTCTTGCTT
ATGGCTGAGAATGTTCCTAAAGTTCATTTCACTATCCCTTAATCCTCAATAGCTACACATACCCCCTTGCCTAGTTAGTCTTGCACTGCT
TTACAACTCTCTTAGGCAAATTACCTAACATAAGCTCCACAGAAGAGTTTTTTAAAACTTAAAATCCCTGTCCCACCAGGTGTGGTGGCT
CATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATTGCTTGAGGCCAGGAGTTCGAGACAAGCCTGACCAACATGGTGACT
CCATCTCTACTAAAAATAAAAAATCAGCCAGGTGTGATGGTGGATGCCTATAAGATCCTAGCTGCTACTCAGGAGGCAGGAGGCTGAGGC
ATGAGAATCACTTGAACCTGTGAGGCAAAGGTTGTAGTGAGCCAAGATCACGTCACTGCACTCCATCCTGGGTGACAGAATGAGACTCTT
GTCTCAAAAAACAAAAAAACCTATTTAGTTTCATCCAGGACATTAAGTGAAAGTGTTTAATGTGAGTGCAGGTCAGTGAAGAATACAATG
GTGCCCCTGCTTTGATTTGTGGGAGGTGCCATCAGTTTTCCCCACCACTGCTTTTGCACCCTCAGTGCAAATATCAACACAGAGAAAAAA
AAAATAATAATAGTATTATGAAAACATTGACTCTGTGGAGACCCTGTGGGTTCTGCAGAGTATACTTTGAAAACTATAAGATTATGAGTT
CTATAAAATACCAAGTACAGATGAACTAGAAAACAAGCATATATCCACAATTACCAGAATTTTCATAGTATTCCTTTTAGTAGATATGCC
ATGACAGTTACTTAGCCACCCCATGCCATCCTGTTGGGAATGCCACTACCTTTGAATTTGGAGCCATCAGTCTATCTGAGGCAAACCTCA
GAAATTACCTGAGCCAGAATCATGCACTTAGCACTGAGTTCAACTCAGTCTTAACGTTGCATTTTGTTGCATCACTTTTGCAGCCAGTAA
ACATTCTGTTTAGAAATAGTTGCTATTGTGGCATCATTCACAGTTGCAATTTTTCTCCTGTGCTGTCATATGCCTGTGCGAAGTGTATTA

>7558_7558_3_ATG3-CLTC_ATG3_chr3_112262904_ENST00000402314_CLTC_chr17_57767997_ENST00000269122_length(amino acids)=221AA_BP=155
MTPWPLTRLHFPSRRGAGRYSGPRMQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAY
LPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKVDKLDASESLRKEEEQATETQPIVY

--------------------------------------------------------------
>7558_7558_4_ATG3-CLTC_ATG3_chr3_112262904_ENST00000402314_CLTC_chr17_57767997_ENST00000579456_length(transcript)=1244nt_BP=781nt
GAGAAGGAAGGGAAGCCGGAAGGGGCGCGAGTGAAGCAAAGCGAGGACAGACAGCTCGCAGAGGGCGAGGGGTGCGTGTGCGTCCGCTTC
TCACCTCAGGTCTCCCTTCGGCCCCGCTGCCCTCCCTCGCGGCTGGGTGACAGCTGGGTCCGGTCCGTCGCGGGCTGCCTGGGGTGCGAG
GATCGCGCACCCCGTCTTCGCGCGCTGTGCCTGCCGCCCCGCCCCCTCGTCCCGCCCGTCCCGTCGCGTCGCGTCCCGTCCCCTCGGGTG
CTGCCAGCCGGGTGCTGATGCGAGTCGGTGGCAGCGAGGACATTTTCTGACTCCCTGGCCCCTGACACGGCTGCACTTTCCATCCCGTCG
CGGGGCCGGCCGCTACTCCGGCCCCAGGATGCAGAATGTGATTAATACTGTGAAGGGAAAGGCACTGGAAGTGGCTGAGTACCTGACCCC
GGTCCTCAAGGAATCAAAGTTTAAGGAAACAGGTGTAATTACCCCAGAAGAGTTTGTGGCAGCTGGAGATCACCTAGTCCACCACTGTCC
AACATGGCAATGGGCTACAGGGGAAGAATTGAAAGTGAAGGCATACCTACCAACAGGCAAACAATTTTTGGTAACCAAAAATGTGCCGTG
CTATAAGCGGTGCAAACAGATGGAATATTCAGATGAATTGGAAGCTATCATTGAAGAAGATGATGGTGATGGCGGATGGGTAGATACATA
TCACAACACAGGTATTACAGGAATAACGGAAGCCGTTAAAGAGATCACACTGGAAAATAAGGTGGATAAATTAGATGCTTCAGAATCACT
GAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTATGGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGT
CCCTCCCCAGGCACCTTTTGGTTATGGTTATACCGCACCACCGTATGGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGC
GCTGATCCTGTAGTCACCTATTTTCGTACTGAAACATCGTCTTTACCCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTT
GTAACCTTTATTTCATGAAGGACTTCTTTTTGTTTCTAACTATAAACTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCAT

>7558_7558_4_ATG3-CLTC_ATG3_chr3_112262904_ENST00000402314_CLTC_chr17_57767997_ENST00000579456_length(amino acids)=221AA_BP=155
MTPWPLTRLHFPSRRGAGRYSGPRMQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEFVAAGDHLVHHCPTWQWATGEELKVKAY
LPTGKQFLVTKNVPCYKRCKQMEYSDELEAIIEEDDGDGGWVDTYHNTGITGITEAVKEITLENKVDKLDASESLRKEEEQATETQPIVY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATG3-CLTC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATG3-CLTC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATG3-CLTC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4518356MiT family translocation renal cell carcinoma2ORPHANET
TgeneC4693389MENTAL RETARDATION, AUTOSOMAL DOMINANT 562GENOMICS_ENGLAND;UNIPROT
TgeneC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneC0334121Inflammatory Myofibroblastic Tumor1ORPHANET