Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATG3-EPHB1 (FusionGDB2 ID:HG64422TG2047)

Fusion Gene Summary for ATG3-EPHB1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG3-EPHB1
Fusion gene ID: hg64422tg2047
HgeneTgene
Gene symbol

ATG3

EPHB1

Gene ID

64422

2047

Gene nameautophagy related 3EPH receptor B1
SynonymsAPG3|APG3-LIKE|APG3L|PC3-96ELK|EPHT2|Hek6|NET
Cytomap('ATG3')('EPHB1')

3q13.2

3q22.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-like-conjugating enzyme ATG32610016C12RikAPG3 autophagy 3-likeATG3 autophagy related 3 homologautophagy-related protein 3hApg3ephrin type-B receptor 1EK6EPH-like kinase 6eph tyrosine kinase 2neuronally-expressed EPH-related tyrosine kinasesoluble EPHB1 variant 1tyrosine-protein kinase receptor EPH-2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000283290, ENST00000402314, 
ENST00000495756, 
Fusion gene scores* DoF score5 X 5 X 2=505 X 5 X 3=75
# samples 55
** MAII scorelog2(5/50*10)=0log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG3 [Title/Abstract] AND EPHB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG3(112277222)-EPHB1(134880858), # samples:1
Anticipated loss of major functional domain due to fusion event.ATG3-EPHB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG3-EPHB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG3-EPHB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG3-EPHB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATG3

GO:0006464

cellular protein modification process

11825910

HgeneATG3

GO:0016567

protein ubiquitination

11825910

TgeneEPHB1

GO:0001525

angiogenesis

9499402

TgeneEPHB1

GO:0031589

cell-substrate adhesion

9430661

TgeneEPHB1

GO:0046328

regulation of JNK cascade

9430661

TgeneEPHB1

GO:0046777

protein autophosphorylation

18034775

TgeneEPHB1

GO:0048013

ephrin receptor signaling pathway

12925710|18034775

TgeneEPHB1

GO:0060326

cell chemotaxis

12925710

TgeneEPHB1

GO:0070372

regulation of ERK1 and ERK2 cascade

12925710|18034775


check buttonFusion gene breakpoints across ATG3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EPHB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for ATG3-EPHB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283290ENST00000398015ATG3chr3112277222-EPHB1chr3134880858+0.000698770.9993012
ENST00000402314ENST00000398015ATG3chr3112277222-EPHB1chr3134880858+0.0007007320.9992993

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Fusion Genomic Features for ATG3-EPHB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATG3chr3112277222-EPHB1chr3134880859+5.17E-070.9999995
ATG3chr3112277222-EPHB1chr3134880859+5.17E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATG3-EPHB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:112277222/chr3:134880858)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEPHB1chr3:112277222chr3:134880858ENST00000398015516619_882474985.0DomainProtein kinase
TgeneEPHB1chr3:112277222chr3:134880858ENST00000398015516911_975474985.0DomainSAM
TgeneEPHB1chr3:112277222chr3:134880858ENST00000398015516982_984474985.0MotifPDZ-binding
TgeneEPHB1chr3:112277222chr3:134880858ENST00000398015516625_633474985.0Nucleotide bindingATP
TgeneEPHB1chr3:112277222chr3:134880858ENST00000398015516564_984474985.0Topological domainCytoplasmic
TgeneEPHB1chr3:112277222chr3:134880858ENST00000398015516541_563474985.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATG3chr3:112277222chr3:134880858ENST00000283290-212166_16938315.0MotifNote=Caspase cleavage motif LETD
HgeneATG3chr3:112277222chr3:134880858ENST00000402314-211166_16938312.0MotifNote=Caspase cleavage motif LETD
TgeneEPHB1chr3:112277222chr3:134880858ENST00000398015516183_319474985.0Compositional biasNote=Cys-rich
TgeneEPHB1chr3:112277222chr3:134880858ENST0000039801551619_201474985.0DomainEph LBD
TgeneEPHB1chr3:112277222chr3:134880858ENST00000398015516322_432474985.0DomainFibronectin type-III 1
TgeneEPHB1chr3:112277222chr3:134880858ENST00000398015516433_528474985.0DomainFibronectin type-III 2
TgeneEPHB1chr3:112277222chr3:134880858ENST0000039801551618_540474985.0Topological domainExtracellular


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Fusion Gene Sequence for ATG3-EPHB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7559_7559_1_ATG3-EPHB1_ATG3_chr3_112277222_ENST00000283290_EPHB1_chr3_134880858_ENST00000398015_length(transcript)=3429nt_BP=549nt
TAGTGTCACGTGAGGCCCCGGTGGCGGCGCAGCTACGGCAAGAGAGTGAGAAGGAAGGGAAGCCGGAAGGGGCGCGAGTGAAGCAAAGCG
AGGACAGACAGCTCGCAGAGGGCGAGGGGTGCGTGTGCGTCCGCTTCTCACCTCAGGTCTCCCTTCGGCCCCGCTGCCCTCCCTCGCGGC
TGGGTGACAGCTGGGTCCGGTCCGTCGCGGGCTGCCTGGGGTGCGAGGATCGCGCACCCCGTCTTCGCGCGCTGTGCCTGCCGCCCCGCC
CCCTCGTCCCGCCCGTCCCGTCGCGTCGCGTCCCGTCCCCTCGGGTGCTGCCAGCCGGGTGCTGATGCGAGTCGGTGGCAGCGAGGACAT
TTTCTGACTCCCTGGCCCCTGACACGGCTGCACTTTCCATCCCGTCGCGGGGCCGGCCGCTACTCCGGCCCCAGGATGCAGAATGTGATT
AATACTGTGAAGGGAAAGGCACTGGAAGTGGCTGAGTACCTGACCCCGGTCCTCAAGGAATCAAAGTTTAAGGAAACAGGTGTAATTACC
CCAGAAGAGGAACACAATGAGTTCAACTCCTCCATGGCCAGGAGTCAGACCAACACAGCAAGGATTGATGGGCTGCGGCCTGGCATGGTA
TATGTGGTACAGGTGCGTGCCCGCACTGTTGCTGGCTACGGCAAGTTCAGTGGCAAGATGTGCTTCCAGACTCTGACTGACGATGATTAC
AAGTCAGAGCTGAGGGAGCAGCTGCCCCTGATTGCTGGCTCGGCAGCGGCCGGGGTCGTGTTCGTTGTGTCCTTGGTGGCCATCTCTATC
GTCTGTAGCAGGAAACGGGCTTATAGCAAAGAGGCTGTGTACAGCGATAAGCTCCAGCATTACAGCACAGGCCGAGGCTCCCCAGGGATG
AAGATCTACATTGACCCCTTCACTTACGAGGATCCCAACGAAGCTGTCCGGGAGTTTGCCAAGGAGATTGATGTATCTTTTGTGAAAATT
GAAGAGGTCATCGGAGCAGGGGAGTTTGGAGAAGTGTACAAGGGGCGTTTGAAACTGCCAGGCAAGAGGGAAATCTACGTGGCCATCAAG
ACCCTGAAGGCAGGGTACTCGGAGAAGCAGCGTCGGGACTTTCTGAGTGAGGCGAGCATCATGGGCCAGTTCGACCATCCTAACATCATT
CGCCTGGAGGGTGTGGTCACCAAGAGTCGGCCTGTCATGATCATCACAGAGTTCATGGAGAATGGTGCATTGGATTCTTTCCTCAGGCAA
AATGACGGGCAGTTCACCGTGATCCAGCTTGTGGGTATGCTCAGGGGCATCGCTGCTGGCATGAAGTACCTGGCTGAGATGAATTATGTG
CATCGGGACCTGGCTGCTAGGAACATTCTGGTCAACAGTAACCTGGTGTGCAAGGTGTCCGACTTTGGCCTCTCCCGCTACCTCCAGGAT
GACACCTCAGATCCCACCTACACCAGCTCCTTGGGAGGGAAGATCCCTGTGAGATGGACAGCTCCAGAGGCCATCGCCTACCGCAAGTTC
ACTTCAGCCAGCGACGTTTGGAGCTATGGGATCGTCATGTGGGAAGTCATGTCATTTGGAGAGAGACCCTATTGGGATATGTCCAACCAA
GATGTCATCAATGCCATCGAGCAGGACTACCGGCTGCCCCCACCCATGGACTGTCCAGCTGCTCTACACCAGCTCATGCTGGACTGTTGG
CAGAAGGACCGGAACAGCCGGCCCCGGTTTGCGGAGATTGTCAACACCCTAGATAAGATGATCCGGAACCCGGCAAGTCTCAAGACTGTG
GCAACCATCACCGCCGTGCCTTCCCAGCCCCTGCTCGACCGCTCCATCCCAGACTTCACGGCCTTTACCACCGTGGATGACTGGCTCAGC
GCCATCAAAATGGTCCAGTACAGGGACAGCTTCCTCACTGCTGGCTTCACCTCCCTCCAGCTGGTCACCCAGATGACATCAGAAGACCTC
CTGAGAATAGGCATCACCTTGGCAGGCCATCAGAAGAAGATCCTGAACAGCATTCATTCTATGAGGGTCCAGATAAGTCAGTCACCAACG
GCAATGGCATGAGAACTCTTGTTTCTTGGGGAAGGAGAGGAGGGAAAAGGACCAGGGTCAAGGGGGACCAGAGGTTGACCACTGTGGAAT
GTACTGGAGAGACTGGCTTCTCAGCTGAGGAATGCATTTCCATCAGTGAAGAATCAACCGGACCTGTTGCTAGCAGGCAATCTCCATTTC
TCAGTGACAGAAGCATGTTTGAGATGCCGTGGGAAACCAAATATATAATAATAAAAATATAAAAAGGTGATGTTCAACAGAAGTGAAGAC
AAAACAATATGCATCAGGAGAACAAGAGTAAACCCAGCTCCCATTCTCAGTGGGCTGCAGTTGCCCAACCACAGGAAGAAAGGGAAGGAG
GTAGAGGGAAGAAACAGAAGCAGTGTTCCATTTTCTTCCTCACCAATGACATTCTTTTCTTTTCTCCTTTCGTACTCCTCCCTGAGAGTC
CCCTCCCTTCTCCCACACTCGTTTCCCTTTGCTCATGACTCCTGTAGGGAAGTTTCTTCAAACAAAACCCAGCTCCTGAGTCTCCAGATG
TTGTTCTGTCAGTTGCCAAAGGACTTTGCTGACCACTGCATGGGGATCCAACCAATTCAATTAATGTCTTCATATTGAAGAAGAGATGTA
CCTTCAATTGAAAACCTCGTTTTTCTTTTGTTTGCATTTTCTGCAAAAAGGAAAAAGAAACCACAAATTGGGGAAAAAAAAAGAAGAAAA
ACCTGTTTCCGTGTGCAAAAGCACACATATGTATGTCTGTGTTATAAAATGACTGTGCTTGTTCGTAACAGATGCAAACAAGAAAGAAGA
ACTGGGAAGTCTTTGTCCCTAGGAAATCCAAAGGGGCTGGAATATGGTGTTGGTTTGGCTTTCTGGTTGGCCCAATCGGCCTATTGGCTC
AATGGGAAGAGAGGAGAGGGAGAAAAATAAAATGAAAGGAAAAAAAAAAGTTTGCAAATTCAGACAGGAAACAGGTGAGTGGTTTGAATT
GGATGCAGTGTGGGCCATCCTGGAATGATACTGACTGATTAATTATTCCTGATAACATCTCAAGAAAAGGAGAAGGAAAGTGTTTCTGGA
GAATGTTCTTTCACATCACTGGAATCTGCAATTCAAGAAGTGACAAGGGAGAATTCTTGCTTTACCTATGGACTGGCTTAAGCCGTGTGG
CATCCGAGGAATGTTTCAAATGTGTCTGTGTTTCTCTTTACATTCCTTGTTGTACCTCATTGTTCAATTCACTTTTGTAAATTCCACCTA
ACATTTAATTATTTTAAATTTCTCCTTTTACCTTAATCTCCTTGCTAATTTTATCTGTCTAATTAAAAAGAGCAGAAGCATGTCTGGGTT

>7559_7559_1_ATG3-EPHB1_ATG3_chr3_112277222_ENST00000283290_EPHB1_chr3_134880858_ENST00000398015_length(amino acids)=572AA_BP=62
MTPWPLTRLHFPSRRGAGRYSGPRMQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEEHNEFNSSMARSQTNTARIDGLRPGMVY
VVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMK
IYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIR
LEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDD
TSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQ
KDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLL

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>7559_7559_2_ATG3-EPHB1_ATG3_chr3_112277222_ENST00000402314_EPHB1_chr3_134880858_ENST00000398015_length(transcript)=3382nt_BP=502nt
GAGAAGGAAGGGAAGCCGGAAGGGGCGCGAGTGAAGCAAAGCGAGGACAGACAGCTCGCAGAGGGCGAGGGGTGCGTGTGCGTCCGCTTC
TCACCTCAGGTCTCCCTTCGGCCCCGCTGCCCTCCCTCGCGGCTGGGTGACAGCTGGGTCCGGTCCGTCGCGGGCTGCCTGGGGTGCGAG
GATCGCGCACCCCGTCTTCGCGCGCTGTGCCTGCCGCCCCGCCCCCTCGTCCCGCCCGTCCCGTCGCGTCGCGTCCCGTCCCCTCGGGTG
CTGCCAGCCGGGTGCTGATGCGAGTCGGTGGCAGCGAGGACATTTTCTGACTCCCTGGCCCCTGACACGGCTGCACTTTCCATCCCGTCG
CGGGGCCGGCCGCTACTCCGGCCCCAGGATGCAGAATGTGATTAATACTGTGAAGGGAAAGGCACTGGAAGTGGCTGAGTACCTGACCCC
GGTCCTCAAGGAATCAAAGTTTAAGGAAACAGGTGTAATTACCCCAGAAGAGGAACACAATGAGTTCAACTCCTCCATGGCCAGGAGTCA
GACCAACACAGCAAGGATTGATGGGCTGCGGCCTGGCATGGTATATGTGGTACAGGTGCGTGCCCGCACTGTTGCTGGCTACGGCAAGTT
CAGTGGCAAGATGTGCTTCCAGACTCTGACTGACGATGATTACAAGTCAGAGCTGAGGGAGCAGCTGCCCCTGATTGCTGGCTCGGCAGC
GGCCGGGGTCGTGTTCGTTGTGTCCTTGGTGGCCATCTCTATCGTCTGTAGCAGGAAACGGGCTTATAGCAAAGAGGCTGTGTACAGCGA
TAAGCTCCAGCATTACAGCACAGGCCGAGGCTCCCCAGGGATGAAGATCTACATTGACCCCTTCACTTACGAGGATCCCAACGAAGCTGT
CCGGGAGTTTGCCAAGGAGATTGATGTATCTTTTGTGAAAATTGAAGAGGTCATCGGAGCAGGGGAGTTTGGAGAAGTGTACAAGGGGCG
TTTGAAACTGCCAGGCAAGAGGGAAATCTACGTGGCCATCAAGACCCTGAAGGCAGGGTACTCGGAGAAGCAGCGTCGGGACTTTCTGAG
TGAGGCGAGCATCATGGGCCAGTTCGACCATCCTAACATCATTCGCCTGGAGGGTGTGGTCACCAAGAGTCGGCCTGTCATGATCATCAC
AGAGTTCATGGAGAATGGTGCATTGGATTCTTTCCTCAGGCAAAATGACGGGCAGTTCACCGTGATCCAGCTTGTGGGTATGCTCAGGGG
CATCGCTGCTGGCATGAAGTACCTGGCTGAGATGAATTATGTGCATCGGGACCTGGCTGCTAGGAACATTCTGGTCAACAGTAACCTGGT
GTGCAAGGTGTCCGACTTTGGCCTCTCCCGCTACCTCCAGGATGACACCTCAGATCCCACCTACACCAGCTCCTTGGGAGGGAAGATCCC
TGTGAGATGGACAGCTCCAGAGGCCATCGCCTACCGCAAGTTCACTTCAGCCAGCGACGTTTGGAGCTATGGGATCGTCATGTGGGAAGT
CATGTCATTTGGAGAGAGACCCTATTGGGATATGTCCAACCAAGATGTCATCAATGCCATCGAGCAGGACTACCGGCTGCCCCCACCCAT
GGACTGTCCAGCTGCTCTACACCAGCTCATGCTGGACTGTTGGCAGAAGGACCGGAACAGCCGGCCCCGGTTTGCGGAGATTGTCAACAC
CCTAGATAAGATGATCCGGAACCCGGCAAGTCTCAAGACTGTGGCAACCATCACCGCCGTGCCTTCCCAGCCCCTGCTCGACCGCTCCAT
CCCAGACTTCACGGCCTTTACCACCGTGGATGACTGGCTCAGCGCCATCAAAATGGTCCAGTACAGGGACAGCTTCCTCACTGCTGGCTT
CACCTCCCTCCAGCTGGTCACCCAGATGACATCAGAAGACCTCCTGAGAATAGGCATCACCTTGGCAGGCCATCAGAAGAAGATCCTGAA
CAGCATTCATTCTATGAGGGTCCAGATAAGTCAGTCACCAACGGCAATGGCATGAGAACTCTTGTTTCTTGGGGAAGGAGAGGAGGGAAA
AGGACCAGGGTCAAGGGGGACCAGAGGTTGACCACTGTGGAATGTACTGGAGAGACTGGCTTCTCAGCTGAGGAATGCATTTCCATCAGT
GAAGAATCAACCGGACCTGTTGCTAGCAGGCAATCTCCATTTCTCAGTGACAGAAGCATGTTTGAGATGCCGTGGGAAACCAAATATATA
ATAATAAAAATATAAAAAGGTGATGTTCAACAGAAGTGAAGACAAAACAATATGCATCAGGAGAACAAGAGTAAACCCAGCTCCCATTCT
CAGTGGGCTGCAGTTGCCCAACCACAGGAAGAAAGGGAAGGAGGTAGAGGGAAGAAACAGAAGCAGTGTTCCATTTTCTTCCTCACCAAT
GACATTCTTTTCTTTTCTCCTTTCGTACTCCTCCCTGAGAGTCCCCTCCCTTCTCCCACACTCGTTTCCCTTTGCTCATGACTCCTGTAG
GGAAGTTTCTTCAAACAAAACCCAGCTCCTGAGTCTCCAGATGTTGTTCTGTCAGTTGCCAAAGGACTTTGCTGACCACTGCATGGGGAT
CCAACCAATTCAATTAATGTCTTCATATTGAAGAAGAGATGTACCTTCAATTGAAAACCTCGTTTTTCTTTTGTTTGCATTTTCTGCAAA
AAGGAAAAAGAAACCACAAATTGGGGAAAAAAAAAGAAGAAAAACCTGTTTCCGTGTGCAAAAGCACACATATGTATGTCTGTGTTATAA
AATGACTGTGCTTGTTCGTAACAGATGCAAACAAGAAAGAAGAACTGGGAAGTCTTTGTCCCTAGGAAATCCAAAGGGGCTGGAATATGG
TGTTGGTTTGGCTTTCTGGTTGGCCCAATCGGCCTATTGGCTCAATGGGAAGAGAGGAGAGGGAGAAAAATAAAATGAAAGGAAAAAAAA
AAGTTTGCAAATTCAGACAGGAAACAGGTGAGTGGTTTGAATTGGATGCAGTGTGGGCCATCCTGGAATGATACTGACTGATTAATTATT
CCTGATAACATCTCAAGAAAAGGAGAAGGAAAGTGTTTCTGGAGAATGTTCTTTCACATCACTGGAATCTGCAATTCAAGAAGTGACAAG
GGAGAATTCTTGCTTTACCTATGGACTGGCTTAAGCCGTGTGGCATCCGAGGAATGTTTCAAATGTGTCTGTGTTTCTCTTTACATTCCT
TGTTGTACCTCATTGTTCAATTCACTTTTGTAAATTCCACCTAACATTTAATTATTTTAAATTTCTCCTTTTACCTTAATCTCCTTGCTA

>7559_7559_2_ATG3-EPHB1_ATG3_chr3_112277222_ENST00000402314_EPHB1_chr3_134880858_ENST00000398015_length(amino acids)=572AA_BP=62
MTPWPLTRLHFPSRRGAGRYSGPRMQNVINTVKGKALEVAEYLTPVLKESKFKETGVITPEEEHNEFNSSMARSQTNTARIDGLRPGMVY
VVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMK
IYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIR
LEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDD
TSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQ
KDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLL

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Fusion Gene PPI Analysis for ATG3-EPHB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATG3-EPHB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATG3-EPHB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource