Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SUDS3-EEA1 (FusionGDB2 ID:HG64426TG8411)

Fusion Gene Summary for SUDS3-EEA1

check button Fusion gene summary
Fusion gene informationFusion gene name: SUDS3-EEA1
Fusion gene ID: hg64426tg8411
HgeneTgene
Gene symbol

SUDS3

EEA1

Gene ID

64426

8411

Gene nameSDS3 homolog, SIN3A corepressor complex componentearly endosome antigen 1
SynonymsSAP45|SDS3MST105|MSTP105|ZFYVE2
Cytomap('SUDS3')('EEA1')

12q24.23

12q22

Type of geneprotein-codingprotein-coding
Descriptionsin3 histone deacetylase corepressor complex component SDS345 kDa Sin3-associated polypeptidesin3A-associated protein, 45kDasuppressor of defective silencing 3 protein homologearly endosome antigen 1early endosome antigen 1, 162kDearly endosome-associated proteinendosome-associated protein p162zinc finger FYVE domain-containing protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000541280, ENST00000397564, 
ENST00000543473, 
Fusion gene scores* DoF score3 X 3 X 2=1827 X 9 X 13=3159
# samples 327
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/3159*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SUDS3 [Title/Abstract] AND EEA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSUDS3(118841322)-EEA1(93251261), # samples:1
Anticipated loss of major functional domain due to fusion event.SUDS3-EEA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SUDS3-EEA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SUDS3-EEA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SUDS3-EEA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSUDS3

GO:0016575

histone deacetylation

21239494


check buttonFusion gene breakpoints across SUDS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EEA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0129-01ASUDS3chr12

118841322

+EEA1chr12

93251261

-


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Fusion Gene ORF analysis for SUDS3-EEA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000541280ENST00000322349SUDS3chr12

118841322

+EEA1chr12

93251261

-
3UTR-5UTRENST00000541280ENST00000547833SUDS3chr12

118841322

+EEA1chr12

93251261

-
5CDS-5UTRENST00000397564ENST00000547833SUDS3chr12

118841322

+EEA1chr12

93251261

-
5CDS-5UTRENST00000543473ENST00000547833SUDS3chr12

118841322

+EEA1chr12

93251261

-
In-frameENST00000397564ENST00000322349SUDS3chr12

118841322

+EEA1chr12

93251261

-
In-frameENST00000543473ENST00000322349SUDS3chr12

118841322

+EEA1chr12

93251261

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000543473SUDS3chr12118841322+ENST00000322349EEA1chr1293251261-104801115112851051325
ENST00000397564SUDS3chr12118841322+ENST00000322349EEA1chr1293251261-1031094595849351325

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543473ENST00000322349SUDS3chr12118841322+EEA1chr1293251261-0.0008351270.99916494
ENST00000397564ENST00000322349SUDS3chr12118841322+EEA1chr1293251261-0.0007133060.9992867

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Fusion Genomic Features for SUDS3-EEA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for SUDS3-EEA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:118841322/chr12:93251261)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUDS3chr12:118841322chr12:93251261ENST00000543473+101266_171267329.0Coiled coilOntology_term=ECO:0000255
TgeneEEA1chr12:118841322chr12:93251261ENST000003223492291093_1231811412.0Compositional biasNote=Glu/Lys-rich
TgeneEEA1chr12:118841322chr12:93251261ENST00000322349229397_758811412.0Compositional biasNote=Gln/Glu/Lys-rich
TgeneEEA1chr12:118841322chr12:93251261ENST00000322349229937_1032811412.0Compositional biasNote=Gln/Glu/Lys-rich
TgeneEEA1chr12:118841322chr12:93251261ENST000003223492291352_1410811412.0Zinc fingerFYVE-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEEA1chr12:118841322chr12:93251261ENST0000032234922974_1348811412.0Coiled coilOntology_term=ECO:0000255
TgeneEEA1chr12:118841322chr12:93251261ENST0000032234922941_64811412.0Zinc fingerC2H2-type


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Fusion Gene Sequence for SUDS3-EEA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87975_87975_1_SUDS3-EEA1_SUDS3_chr12_118841322_ENST00000397564_EEA1_chr12_93251261_ENST00000322349_length(transcript)=10310nt_BP=945nt
GCGGAGACGGGGAAGGGGTCGCCGTGGCTGCCGGTCCTCGAGTTGGGGGCTGCCGCGGACACTGCTAGGCAGACGGCGAGTACCGAGCGC
GGGTGGCCGCGGTGTCCGTGGGCCACGCTCAGCTGCGGTCAGAGGCGACATGAGTGCCGCGGGGCTGCTGGCCCCGGCCCCGGCCCAGGC
TGGAGCGCCGCCGGCCCCCGAGTACTACCCCGAGGAGGATGAAGAGCTGGAGAGCGCCGAGGACGACGAGCGCAGCTGTCGGGGCCGCGA
GTCGGACGAAGACACTGAGGATGCTAGTGAAACTGACCTGGCAAAGCATGATGAAGAAGACTATGTAGAAATGAAGGAACAGATGTATCA
GGACAAACTGGCTTCTCTCAAGAGGCAGTTGCAACAACTGCAAGAAGGTACATTACAGGAATATCAGAAGAGAATGAAAAAACTAGATCA
GCAGTACAAAGAGAGGATACGGAATGCAGACACACTGTTACTGCAAGCTCAGACTGAACAAGTGGAACGAAATTACATTAAAGAAAAGAA
GGCAGCAGTGAAAGAATTTGAAGACAAGAAGGTTGAGCTGAAAGAGAACCTGATTGCTGAGCTAGAAGAAAAGAAGAAAATGATTGAAAA
TGAAAAGCTGACAATGGAACTGACTGGAGATTCTATGGAGGTGAAACCTATCATGACCAGAAAGTTGCGGAGGCGACCAAATGATCCCGT
CCCCATCCCAGACAAGAGGAGGAAACCTGCTCCAGCCCAGCTAAACTATTTGTTAACAGATGAACAGATCATGGAGGATCTGAGAACATT
AAATAAGCTTAAGTCACCCAAGAGACCAGCATCTCCATCCTCTCCTGAGCACTTGCCTGCAACACCCGCGGAATCTCCAGCCCAGAGGTT
CGAAGCTCGGATAGAAGATGGCAAACTGTACTATGACAAAAGATGAGATGATGTAACACTGCTCAGACAAGAGGTCCAAGACCTACAGGC
TTCACTTAAGGAAGAAAAATGGTACTCGGAAGAATTAAAGAAGGAATTAGAAAAATATCAAGGGCTGCAGCAGCAAGAGGCCAAACCTGA
TGGGTTGGTGACTGATTCATCAGCAGAACTACAGTCTTTGGAACAGCAATTAGAAGAAGCCCAAACAGAAAATTTTAATATTAAGCAAAT
GAAAGACTTATTTGAACAGAAAGCAGCCCAACTTGCTACTGAAATTGCAGATATAAAGTCAAAGTATGATGAAGAAAGGAGTCTTCGAGA
AGCTGCTGAACAAAAAGTGACACGTCTGACAGAAGAATTAAACAAAGAGGCAACTGTAATTCAAGATCTGAAGACGGAACTGCTTCAGAG
ACCTGGTATAGAAGATGTTGCCGTGCTAAAGAAAGAACTGGTCCAAGTTCAAACACTAATGGATAACATGACCTTGGAACGTGAGCGAGA
ATCTGAAAAACTCAAAGATGAATGCAAAAAATTGCAGTCACAATATGCTAGCTCAGAGGCCACAATAAGCCAGCTAAGGAGTGAACTTGC
CAAAGGCCCCCAGGAAGTTGCTGTATATGTACAGGAACTACAAAAACTGAAAAGTTCAGTTAATGAATTAACACAAAAAAATCAGACCTT
GACAGAAAACTTGCTGAAAAAAGAACAAGACTATACTAAGTTAGAGGAGAAACATAATGAAGAATCTGTGAGTAAAAAGAATATTCAGGC
AACCCTTCATCAAAAAGACCTAGATTGTCAACAGCTTCAGTCAAGATTGTCTGCATCTGAAACCTCACTGCATAGAATACATGTAGAACT
AAGTGAAAAAGGAGAAGCTACTCAAAAGCTCAAAGAAGAATTATCTGAGGTAGAGACCAAGTACCAGCATCTAAAGGCGGAGTTTAAGCA
GCTACAACAACAGAGAGAAGAAAAGGAGCAGCATGGGTTACAACTCCAAAGTGAAATTAATCAATTACATAGCAAACTTCTGGAGACAGA
GCGCCAACTAGGGGAAGCTCATGGTAGGCTGAAGGAACAGAGACAGCTTTCAAGTGAAAAGTTGATGGATAAAGAACAACAAGTGGCTGA
TTTACAACTCAAACTTTCTCGGTTAGAAGAGCAGTTGAAGGAAAAAGTTACAAATTCTACAGAATTGCAGCATCAATTAGATAAAACAAA
GCAACAGCATCAAGAACAACAGGCTCTTCAGCAAAGCACCACGGCAAAACTTCGAGAAGCTCAGAATGATTTGGAACAAGTTCTACGTCA
AATTGGCGATAAGGACCAAAAGATCCAGAACCTTGAAGCTTTATTACAGAAGAGTAAAGAAAATATTTCATTACTAGAAAAAGAAAGAGA
AGATCTTTATGCAAAAATTCAGGCTGGTGAAGGAGAGACTGCTGTTCTTAACCAGTTACAAGAAAAAAACCATACACTACAGGAGCAAGT
AACTCAACTAACAGAGAAGCTGAAGAATCAGTCAGAAAGTCATAAACAAGCCCAGGAGAATTTGCATGACCAGGTACAAGAGCAGAAGGC
ACATCTTAGAGCTGCACAAGACCGTGTCCTTTCCCTAGAAACTAGTGTCAATGAATTAAATAGTCAATTAAATGAAAGCAAGGAGAAGGT
CTCCCAGCTTGACATACAGATTAAAGCCAAAACCGAACTATTACTATCAGCAGAAGCAGCAAAAACTGCTCAAAGAGCTGATCTTCAGAA
TCATTTGGACACAGCTCAAAATGCATTACAAGATAAACAGCAGGAGTTAAATAAGATTACTACTCAGTTGGATCAGGTCACTGCAAAGTT
ACAAGACAAGCAAGAACATTGCAGTCAGCTGGAAAGTCATCTTAAAGAATATAAAGAGAAATACCTCTCTTTAGAACAGAAAACCGAAGA
GCTAGAAGGTCAAATTAAGAAACTAGAAGCTGATAGTCTTGAAGTTAAAGCAAGCAAGGAGCAGGCTTTGCAAGATCTACAACAGCAAAG
ACAGCTGAACACAGATTTAGAGCTCAGAGCCACAGAATTGAGTAAACAACTTGAAATGGAGAAGGAAATAGTATCCAGTACAAGATTGGA
TCTACAGAAAAAATCTGAAGCCCTTGAAAGTATCAAGCAAAAGCTTACCAAGCAAGAGGAAGAAAAAAAAATCCTGAAACAAGATTTTGA
AACTTTAAGTCAAGAAACAAAGATTCAGCATGAGGAATTGAATAACAGAATTCAAACAACAGTAACAGAACTACAAAAAGTGAAAATGGA
GAAAGAAGCTTTAATGACAGAGCTTTCTACAGTAAAGGACAAACTATCAAAAGTTTCTGATTCTTTGAAAAACTCTAAAAGTGAATTTGA
AAAGGAGAATCAGAAAGGAAAAGCCGCTATATTAGACTTGGAAAAAACTTGCAAAGAATTAAAGCATCAACTTCAAGTGCAGATGGAAAA
CACACTTAAGGAACAGAAGGAACTGAAAAAGTCACTTGAAAAAGAGAAGGAGGCTTCTCATCAGTTGAAATTGGAACTCAATTCAATGCA
GGAACAACTTATACAGGCCCAGAATACTTTAAAACAAAATGAAAAAGAAGAGCAACAACTTCAGGGGAACATAAATGAGCTAAAGCAATC
AAGTGAACAGAAGAAAAAACAAATTGAAGCACTCCAAGGAGAGCTTAAAATTGCTGTTTTACAGAAGACAGAGCTTGAGAATAAACTACA
GCAGCAGTTAACACAGGCAGCCCAGGAACTTGCAGCAGAGAAAGAGAAAATATCAGTATTACAAAACAACTATGAAAAAAGTCAGGAAAC
TTTCAAACAGCTTCAATCTGATTTCTATGGGAGGGAATCTGAACTTCTAGCCACCAGGCAAGATCTTAAGTCTGTAGAAGAGAAGCTTTC
TCTAGCACAGGAGGACTTGATTTCAAACAGAAATCAAATTGGAAATCAAAATAAATTGATTCAAGAACTGAAGACTGCCAAGGCTACATT
GGAGCAGGATTCAGCAAAGAAAGAACAGCAATTGCAGGAGCGATGTAAAGCACTACAAGACATTCAGAAAGAAAAGTCACTGAAAGAAAA
AGAACTGGTAAATGAGAAGTCTAAATTGGCAGAGATAGAAGAAATTAAATGTAGACAAGAAAAAGAAATCACTAAACTAAACGAAGAACT
CAAGTCCCACAAACTAGAAAGCATAAAGGAGATAACAAATCTTAAAGATGCTAAACAGCTTCTAATTCAGCAGAAATTAGAACTTCAAGG
AAAAGCGGACTCCCTGAAGGCAGCTGTTGAACAGGAGAAGAGAAATCAGCAGATACTAAAAGACCAGGTGAAAAAGGAAGAAGAGGAGCT
GAAGAAAGAATTTATTGAGAAAGAAGCTAAGTTGCATTCCGAAATAAAAGAAAAGGAAGTAGGAATGAAGAAGCATGAAGAAAATGAGGC
TAAACTTACCATGCAGATTACAGCATTAAATGAAAACTTAGGCACTGTGAAGAAGGAGTGGCAATCTAGTCAACGGAGAGTTAGTGAGCT
TGAGAAACAAACGGATGACTTACGGGGTGAAATTGCAGTATTAGAAGCAACGGTTCAGAATAATCAAGATGAAAGGAGAGCACTACTGGA
AAGATGTCTTAAAGGAGAAGGTGAAATAGAAAAGCTTCAAACCAAAGTATTAGAATTGCAAAGAAAGCTGGATAATACAACTGCAGCAGT
GCAGGAGCTGGGCAGAGAAAACCAATCACTTCAGATCAAACATACACAAGCGTTGAATAGAAAGTGGGCCGAAGACAATGAAGTACAAAA
CTGTATGGCCTGTGGGAAAGGCTTTTCAGTAACAGTGAGACGGCATCACTGCCGACAGTGTGGAAATATCTTCTGTGCTGAATGTTCAGC
CAAAAATGCCTTAACTCCTTCCTCCAAGAAGCCTGTTCGTGTCTGTGATGCATGTTTCAATGACTTGCAAGGATAATGGGTTATCACAAC
TTCAGAGTAATATTACACTAACATTAGATTTTTAATAAATGTACTTAATAGAGGTCTTGGACTACTATTTGGTTTGGACACTGGTTGCAA
TACTAGACCAAATAGGAATTAGTATATTTTGGAATGTTATGGATATCAAGTAAAACTCTTCTATTTTTGTGAGACTTGGGCTTATCATCT
TTCATTACTTTTTTCCCATTTAGCCCCTGGAATAGCTTTCATGCCAAGTTTAGAATTAGCCAATGAAATGTAAATAAACTTTGGACAGAA
AATAGCAATGTATTTTTTTAATATAATTTCATTATTCACAAATGAAGAATGCAATTCCATAGCTTACTTCTTTCTCCTAAATTTAATGTA
CAAAAATGTACATGGATGATATTATCACTTGTTGCTGTTTTTGTTGCACAATAGCACATTAATTATATTAAATATTCTCTTTGTGAAGTT
ATGCACAGAACTGTAACACTTTCCTCTGCCTTTTTCTCTTATATGTGGGTTCATGGTTCAGTTGCATTGTTATGTTATGAATTTACTACT
TGGGTGTTCTAAATACAGTTTATCTTAAAATATGTAGTAATATGAATTCAAAAATGGTTTTTGTTTTAACAATATTAATTAAATTTTCTT
GGGTGGATTTTATAAAAACCTCTGTAAAATCAATTTGTTTACTTATAGTTATCTGGGGTTGTATTGCAAAGAATAGGGTTAATTTTTCTT
TTTGTCTTTTTCTGTCTCTTTCTTAAACTCCCACGCATTGTCCATTTAGAATCTTAGAAAGCTTCTTACCCTCGCTGTCAGTTGGAGGAT
GAATAATAAACATTGTATAATGTTCTTATTCTCGGTTTCTTGTAAGTGGGAAGTCTTTTGAGATCAGCCTTCATATCATACCCTTATTTT
GTCTCTCTAGCATCTTCAGGAACCTGAGTTTGCTTTTTACATAGATCTGATTTTTTCCTTTATTTGGTTTAACATTTTCAAGCATAGATC
AGCTTCATGTATTTGTTTTATAATTTTGCATCTTAAAGCTAGTAACTAATATTGCTGTGGTCTTATTGGTGAAAACAAAATATAAAATGA
TAAGAAGACATTAAATATTTTACTTTCTATTTCTTACCCTATTGGGAAGAATTTTTAAAAGTTGTAAAATTGACTTAAAGTTAAAATGGT
TCTGAATTTGGTGTTCCATGTCAACTGTTCCCAGTTTTAATTTTAACTTTGCAAAAATAATGTTGTGAAATTCCCTTTAAGTAACTAACA
CCTAGAAATAGAGTATCACCAAAAACAAATGTATTTAGGAATCCCAGTTACAATAAAAACTGAAACAGCATGGCTAAGCATCTTAAGGAT
AATTAAGAAATTAGCTTATTTGTATGCTGAACAATGGAATCGAACTTTAATTTAGCATAGTCTTATTAATTTGGAAAATTGTAAAACATC
TCAAGAGAGAAGTTATTAATATTGGTTTATTAATCTTTCTAGAGAAGAAGTGTAGTTATACATTCATTCAGTGCAATCATTTTATAACAG
TAGTTAATATTTCATTTATAATAGTTCTTAATATACATTTGCTTTCAAATATTCTGAAATGAAATTATATTCATGCTATACCTACAGTGT
ATGTAAACTAAAGAGATCACTACATATTTGTTTAATTATTTAAAAAAAAATTTAAGTAAACCCTGTTGTCATTAGCTATTAAGAACATTG
ATTAAGTCCCTGGACTTGGATAAACATATATCCTTGAACATATATAATGAAGAAATACAGTGGCTCTTTATTAAAAATAATAGTTGGATA
ATATAAACTGAACTATTTATGCATTTTTATATACTTATAAATCCTTCCAAATAGTTTTAATTCTATCCTTTTACATATAAATAACTTAAT
AAGTGTGCTGGAAAAACACAGATATTCACAGCACCACTGTTTTTTTTTTTTTTTTGAGATAATAAATTCCATGAGAAATCTGGGTTTGAA
TATTTGTTTACTTTGTCTCCTAATTGAACACCACTCCAGGCCTTCTGTCTGTCTCCCCTTTACCCCCAAAATACTCACAAAAAAATTTTA
AGACAACAAGTAACCATATATAGGTGTTTGAATGATTTTCTCATTTTTATCTAATTTCATTTCATAAGTCCCGAGTAATTTACCTACCAT
AGGCTACTATACTGATAATATAAATGAAACCGAACATTTTTTGCTACTAACTCTCCCCAATTTAATGTGTTTTCGAAATAAAAATTTAAA
TTTTTTTCCTTTTAATTAAAAAGTCATCTTTGAAGTCCTTATTGGCTGTACATTTTACATGTTTGCTGGTACTATTATTTTGTCAGTCAG
TTAAAGCTGGCATGTACAGCTCTTGGCTTTAATGAAAAGCACATTGACATAATGTTAGTAAATTCCAAACCCCGGCACAGAATGTGAGTT
AAAATTAAGTCTTGCTGGGTTAGTGTACAATAAACTATACCTACAGACTTTTTTTTAATAGAAAGAAGACAAAGCTGCTGGTATAGGATT
TGTTCCTTTGAAGAAAAAATGAGGGAAACAAACACAAAAACCTCAATGCAGTGTATAAATAACATTTTGTTCAACTACCTCTTAATGTGG
AATTATCTACTTTAATAGTTTCCTGACAGTAATGTTAAATAGTAACTGCCAAATTTGTTATTTTCCCATCTCTCTTAAAAAAGTCTTTAT
GATTATTTTATATAGTTTTGAGAACTTTAAAGCCACTTTTTTTTAACCTTACATTTGCATAAAAATGTTTAGCTTTTAAGTAGAGAGCAA
ATTATGATCATATATTTTGATATTCATGACCTGTTTGACTATAGGAGTTTTTTTAAAAAAATGCACTTTGGCTATAAAACCATGGATGAT
TTGATCCATAAGATTTAAATGTGCCACCATTATAGTATTCCTAGACATGAGCTTGATGAATGGTATTCTGTAATTATAACGTGCCACACA
TTATTGTGTCTTAATTGCCCTTAGCCTGAATTTTAATGATCAATTTGTTATTGTTGCAGATGTGAATATTGTGCATAAACTTACTAAATT
TATGTAAAATTGTATAAAATAGAATTAGAAGTCACTAAGTTCTTTCTGTGTAGAAGTAATAAATTTATTGTAACACAATGCAGTTGTGTA
TATGACATTCTGTAATTCCTTGAACTGGATCATATATTCATAAGTTCTGTAGATACTTATGCATGAACATTTTCTCATTTAGTTTTTGGG
TTCATTATTTGTATTGTGTTTACTACTTGTGATCATGTAGTTGTGCCTTACTTTGTGAGAAAGGTTAGCTCAGTAAATACTGCAATTTCT
AAACTCAGTGATTGGAAGGTTATTAATTATAAATGTAACTGATAAAGTACGTGACAGCATTTAAATCTGTATAAAGAACAATGGAAGGAT
CCTTATTGAATTGTTGCTTTTTTTTAATATGTTTAAATATTATATTAAAAACATTTCTTTCTAAACTAGTTGTATTCTGTGACTATAAAT
TGTTTTGTCTAACAAAAGAGAGAACACTGTATTAACCATTTTGCATTAATTTATTTACAGAATATTAGGACTTTGCACTTGGATATAGAC
AGTGGTGTTTTAATGTTGTTCAATTTCGAATAGTAATTAAATTCCTGATCTCAAGAGAAATTATTAATGCCATTTTGCCTTAGACATTCC
ATTTAATATTGTAGAGAATTAACAAAACTAAAAACAAATATAAAAAATATGTAATTAACCCCTTATTTCATTGTGTGTCTGCATTTAATA
CCCAGATGACCATTTAAAGATACTTAAAACATTATTTATTTATTTATTTATTTATTTTTCTCCCTCCCCTCCCCAAAGATACTTTTTGGA
AGGCCCAATGTGCCATTGTTTTTTGCTATTTTTTCTTCCTGGGAGCCACGGTTCTAGAATGGTTTTTGTTCTGACCCCCGTGATCCCTTC
ATTCGAATGTGCTTCATTCTAAACCCTCCAAAGAGTTTAATGTGCATATCCTCAAACATCTAATATATTGTATATTAGACATGTTACTTT
GTGAGCTTTATAGAATTCCAGTTTATGTACAGCATATTCTTGAGCTGTTTTATATATTTTGTTAATTTAGTCAGTCTGTCTCTCCCTTTA
ATGAGATTCAGAGGGAGAAAACTACCTTTATACATGTAAGTCTGTGGTTGCTGGATTCATGGGACTAAAGGAATTTGAGAGGCCACCTCA
TCCTAGTCCACTGCTCACCTCCGAGGTTAGTTTATATCTAAACATTTGCAAGATGATTGTTAATGTAAAAATTTTTTTTAACCAGAAATT
TCTTTATAAAATCTTCTCTTGCATAATCTATATTGTATTCTCCTGGACATAACTGCTTTCAGTCCCATCCAGATGCCATCTCTAGGAATT
CACTTGAAGCTTGAAGTCTATTCTCCCCTTTTTCTCCCCTCCACCTCATTTATTCTTAGCTATTAACAATAGTTACTGTCCTCCAGATTT
TCCTTTTTTTCTTCTATTAAATTTCTGACATTATTATAAAGAGGTTATTAGTCTCCATTCTAATAGTGCTTGCCTTGTACAAAAGCCTTT
CTGCTGCACTTGTCTTTACTGCTTTGTTTGCATAGTGAAATTTCACCTTCCTCAAGGAATTACTGGGCACATGACTTGCCCAAACATTAT
CCTCTCTACCCCATTCTTCAGCTTAACAAAATCAGCTAAGGCTTCAGTTGTCTTGCAGCCAAATTTGATAAATTTACTACTTTCACTTTG
CAAATTGCAAAAGGTACGATTCTGAAATGGAAGTTTGTGGACTTCCCTTTGATGCAATAATCTGACCCTAAGAACTAGTTCCTTGAATGT
AGTTAATAGTATATATCCTGCCATGATAATAATTATTCAAACTGCCTTTCATGATAAAAATTCTGAAGAAATTTGAAGTCCTGCCAAATA
AAATTAAGTGACTGTACTGTGCTAACACACACACACACACACACACACACCAATCAAAACCAGAAAGTATTTTTATGGCAAACACCATCA
TTCTTCAAAAAATAAAGTTAAGAGACAGATACCTTACTATGTCTATGAAAATCTGTACACTTCACAACAGGCCAAGAAAAGCCATGCAAA
AGTGTTAACTGGTGAAAGCCAGATTTTTTTTTTCTTCCTATCTTAAAGTAATGGAATTTAGTCTTTGGGATTTTCTACTTCCACGTTAGA
GTACTATATACCTGAGATGAGTTTGAGAATAGGAATTTTAAAACTGCTACTTAAATGTAGTCCCTATTTATTGCTTTGTATATTAAAAGA

>87975_87975_1_SUDS3-EEA1_SUDS3_chr12_118841322_ENST00000397564_EEA1_chr12_93251261_ENST00000322349_length(amino acids)=1325AA_BP=
MLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIK
SKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE
ATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS
ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE
KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK
ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL
NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE
KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE
EEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE
LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV
LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL
IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ
LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE
WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALN

--------------------------------------------------------------
>87975_87975_2_SUDS3-EEA1_SUDS3_chr12_118841322_ENST00000543473_EEA1_chr12_93251261_ENST00000322349_length(transcript)=10480nt_BP=1115nt
GGATTTTAAGACGGCGATGAAAGGGCTGAGGTTGTGGCGACGGGGGCGTCCAGCGGCATCTCCACTCCCCCAAGGATGGCGGAATCAGGC
CGTTGTCGGGCAGCTCTCGACCCGGAAGTCGCTCGCGGCGCGAGGCCCCCGTTGCCGAGCGCGGGCGCGGGGGGCGGAGCTCGGCGGAGA
CGGGGAAGGGGTCGCCGTGGCTGCCGGTCCTCGAGTTGGGGGCTGCCGCGGACACTGCTAGGCAGACGGCGAGTACCGAGCGCGGGTGGC
CGCGGTGTCCGTGGGCCACGCTCAGCTGCGGTCAGAGGCGACATGAGTGCCGCGGGGCTGCTGGCCCCGGCCCCGGCCCAGGCTGGAGCG
CCGCCGGCCCCCGAGTACTACCCCGAGGAGGATGAAGAGCTGGAGAGCGCCGAGGACGACGAGCGCAGCTGTCGGGGCCGCGAGTCGGAC
GAAGACACTGAGGATGCTAGTGAAACTGACCTGGCAAAGCATGATGAAGAAGACTATGTAGAAATGAAGGAACAGATGTATCAGGACAAA
CTGGCTTCTCTCAAGAGGCAGTTGCAACAACTGCAAGAAGGTACATTACAGGAATATCAGAAGAGAATGAAAAAACTAGATCAGCAGTAC
AAAGAGAGGATACGGAATGCAGAACTCTTCCTCCAGCTGGAAACTGAACAAGTGGAACGAAATTACATTAAAGAAAAGAAGGCAGCAGTG
AAAGAATTTGAAGACAAGAAGGTTGAGCTGAAAGAGAACCTGATTGCTGAGCTAGAAGAAAAGAAGAAAATGATTGAAAATGAAAAGCTG
ACAATGGAACTGACTGGAGATTCTATGGAGGTGAAACCTATCATGACCAGAAAGTTGCGGAGGCGACCAAATGATCCCGTCCCCATCCCA
GACAAGAGGAGGAAACCTGCTCCAGCCCAGCTAAACTATTTGTTAACAGATGAACAGATCATGGAGGATCTGAGAACATTAAATAAGCTT
AAGTCACCCAAGAGACCAGCATCTCCATCCTCTCCTGAGCACTTGCCTGCAACACCCGCGGAATCTCCAGCCCAGAGGTTCGAAGCTCGG
ATAGAAGATGGCAAACTGTACTATGACAAAAGATGAGATGATGTAACACTGCTCAGACAAGAGGTCCAAGACCTACAGGCTTCACTTAAG
GAAGAAAAATGGTACTCGGAAGAATTAAAGAAGGAATTAGAAAAATATCAAGGGCTGCAGCAGCAAGAGGCCAAACCTGATGGGTTGGTG
ACTGATTCATCAGCAGAACTACAGTCTTTGGAACAGCAATTAGAAGAAGCCCAAACAGAAAATTTTAATATTAAGCAAATGAAAGACTTA
TTTGAACAGAAAGCAGCCCAACTTGCTACTGAAATTGCAGATATAAAGTCAAAGTATGATGAAGAAAGGAGTCTTCGAGAAGCTGCTGAA
CAAAAAGTGACACGTCTGACAGAAGAATTAAACAAAGAGGCAACTGTAATTCAAGATCTGAAGACGGAACTGCTTCAGAGACCTGGTATA
GAAGATGTTGCCGTGCTAAAGAAAGAACTGGTCCAAGTTCAAACACTAATGGATAACATGACCTTGGAACGTGAGCGAGAATCTGAAAAA
CTCAAAGATGAATGCAAAAAATTGCAGTCACAATATGCTAGCTCAGAGGCCACAATAAGCCAGCTAAGGAGTGAACTTGCCAAAGGCCCC
CAGGAAGTTGCTGTATATGTACAGGAACTACAAAAACTGAAAAGTTCAGTTAATGAATTAACACAAAAAAATCAGACCTTGACAGAAAAC
TTGCTGAAAAAAGAACAAGACTATACTAAGTTAGAGGAGAAACATAATGAAGAATCTGTGAGTAAAAAGAATATTCAGGCAACCCTTCAT
CAAAAAGACCTAGATTGTCAACAGCTTCAGTCAAGATTGTCTGCATCTGAAACCTCACTGCATAGAATACATGTAGAACTAAGTGAAAAA
GGAGAAGCTACTCAAAAGCTCAAAGAAGAATTATCTGAGGTAGAGACCAAGTACCAGCATCTAAAGGCGGAGTTTAAGCAGCTACAACAA
CAGAGAGAAGAAAAGGAGCAGCATGGGTTACAACTCCAAAGTGAAATTAATCAATTACATAGCAAACTTCTGGAGACAGAGCGCCAACTA
GGGGAAGCTCATGGTAGGCTGAAGGAACAGAGACAGCTTTCAAGTGAAAAGTTGATGGATAAAGAACAACAAGTGGCTGATTTACAACTC
AAACTTTCTCGGTTAGAAGAGCAGTTGAAGGAAAAAGTTACAAATTCTACAGAATTGCAGCATCAATTAGATAAAACAAAGCAACAGCAT
CAAGAACAACAGGCTCTTCAGCAAAGCACCACGGCAAAACTTCGAGAAGCTCAGAATGATTTGGAACAAGTTCTACGTCAAATTGGCGAT
AAGGACCAAAAGATCCAGAACCTTGAAGCTTTATTACAGAAGAGTAAAGAAAATATTTCATTACTAGAAAAAGAAAGAGAAGATCTTTAT
GCAAAAATTCAGGCTGGTGAAGGAGAGACTGCTGTTCTTAACCAGTTACAAGAAAAAAACCATACACTACAGGAGCAAGTAACTCAACTA
ACAGAGAAGCTGAAGAATCAGTCAGAAAGTCATAAACAAGCCCAGGAGAATTTGCATGACCAGGTACAAGAGCAGAAGGCACATCTTAGA
GCTGCACAAGACCGTGTCCTTTCCCTAGAAACTAGTGTCAATGAATTAAATAGTCAATTAAATGAAAGCAAGGAGAAGGTCTCCCAGCTT
GACATACAGATTAAAGCCAAAACCGAACTATTACTATCAGCAGAAGCAGCAAAAACTGCTCAAAGAGCTGATCTTCAGAATCATTTGGAC
ACAGCTCAAAATGCATTACAAGATAAACAGCAGGAGTTAAATAAGATTACTACTCAGTTGGATCAGGTCACTGCAAAGTTACAAGACAAG
CAAGAACATTGCAGTCAGCTGGAAAGTCATCTTAAAGAATATAAAGAGAAATACCTCTCTTTAGAACAGAAAACCGAAGAGCTAGAAGGT
CAAATTAAGAAACTAGAAGCTGATAGTCTTGAAGTTAAAGCAAGCAAGGAGCAGGCTTTGCAAGATCTACAACAGCAAAGACAGCTGAAC
ACAGATTTAGAGCTCAGAGCCACAGAATTGAGTAAACAACTTGAAATGGAGAAGGAAATAGTATCCAGTACAAGATTGGATCTACAGAAA
AAATCTGAAGCCCTTGAAAGTATCAAGCAAAAGCTTACCAAGCAAGAGGAAGAAAAAAAAATCCTGAAACAAGATTTTGAAACTTTAAGT
CAAGAAACAAAGATTCAGCATGAGGAATTGAATAACAGAATTCAAACAACAGTAACAGAACTACAAAAAGTGAAAATGGAGAAAGAAGCT
TTAATGACAGAGCTTTCTACAGTAAAGGACAAACTATCAAAAGTTTCTGATTCTTTGAAAAACTCTAAAAGTGAATTTGAAAAGGAGAAT
CAGAAAGGAAAAGCCGCTATATTAGACTTGGAAAAAACTTGCAAAGAATTAAAGCATCAACTTCAAGTGCAGATGGAAAACACACTTAAG
GAACAGAAGGAACTGAAAAAGTCACTTGAAAAAGAGAAGGAGGCTTCTCATCAGTTGAAATTGGAACTCAATTCAATGCAGGAACAACTT
ATACAGGCCCAGAATACTTTAAAACAAAATGAAAAAGAAGAGCAACAACTTCAGGGGAACATAAATGAGCTAAAGCAATCAAGTGAACAG
AAGAAAAAACAAATTGAAGCACTCCAAGGAGAGCTTAAAATTGCTGTTTTACAGAAGACAGAGCTTGAGAATAAACTACAGCAGCAGTTA
ACACAGGCAGCCCAGGAACTTGCAGCAGAGAAAGAGAAAATATCAGTATTACAAAACAACTATGAAAAAAGTCAGGAAACTTTCAAACAG
CTTCAATCTGATTTCTATGGGAGGGAATCTGAACTTCTAGCCACCAGGCAAGATCTTAAGTCTGTAGAAGAGAAGCTTTCTCTAGCACAG
GAGGACTTGATTTCAAACAGAAATCAAATTGGAAATCAAAATAAATTGATTCAAGAACTGAAGACTGCCAAGGCTACATTGGAGCAGGAT
TCAGCAAAGAAAGAACAGCAATTGCAGGAGCGATGTAAAGCACTACAAGACATTCAGAAAGAAAAGTCACTGAAAGAAAAAGAACTGGTA
AATGAGAAGTCTAAATTGGCAGAGATAGAAGAAATTAAATGTAGACAAGAAAAAGAAATCACTAAACTAAACGAAGAACTCAAGTCCCAC
AAACTAGAAAGCATAAAGGAGATAACAAATCTTAAAGATGCTAAACAGCTTCTAATTCAGCAGAAATTAGAACTTCAAGGAAAAGCGGAC
TCCCTGAAGGCAGCTGTTGAACAGGAGAAGAGAAATCAGCAGATACTAAAAGACCAGGTGAAAAAGGAAGAAGAGGAGCTGAAGAAAGAA
TTTATTGAGAAAGAAGCTAAGTTGCATTCCGAAATAAAAGAAAAGGAAGTAGGAATGAAGAAGCATGAAGAAAATGAGGCTAAACTTACC
ATGCAGATTACAGCATTAAATGAAAACTTAGGCACTGTGAAGAAGGAGTGGCAATCTAGTCAACGGAGAGTTAGTGAGCTTGAGAAACAA
ACGGATGACTTACGGGGTGAAATTGCAGTATTAGAAGCAACGGTTCAGAATAATCAAGATGAAAGGAGAGCACTACTGGAAAGATGTCTT
AAAGGAGAAGGTGAAATAGAAAAGCTTCAAACCAAAGTATTAGAATTGCAAAGAAAGCTGGATAATACAACTGCAGCAGTGCAGGAGCTG
GGCAGAGAAAACCAATCACTTCAGATCAAACATACACAAGCGTTGAATAGAAAGTGGGCCGAAGACAATGAAGTACAAAACTGTATGGCC
TGTGGGAAAGGCTTTTCAGTAACAGTGAGACGGCATCACTGCCGACAGTGTGGAAATATCTTCTGTGCTGAATGTTCAGCCAAAAATGCC
TTAACTCCTTCCTCCAAGAAGCCTGTTCGTGTCTGTGATGCATGTTTCAATGACTTGCAAGGATAATGGGTTATCACAACTTCAGAGTAA
TATTACACTAACATTAGATTTTTAATAAATGTACTTAATAGAGGTCTTGGACTACTATTTGGTTTGGACACTGGTTGCAATACTAGACCA
AATAGGAATTAGTATATTTTGGAATGTTATGGATATCAAGTAAAACTCTTCTATTTTTGTGAGACTTGGGCTTATCATCTTTCATTACTT
TTTTCCCATTTAGCCCCTGGAATAGCTTTCATGCCAAGTTTAGAATTAGCCAATGAAATGTAAATAAACTTTGGACAGAAAATAGCAATG
TATTTTTTTAATATAATTTCATTATTCACAAATGAAGAATGCAATTCCATAGCTTACTTCTTTCTCCTAAATTTAATGTACAAAAATGTA
CATGGATGATATTATCACTTGTTGCTGTTTTTGTTGCACAATAGCACATTAATTATATTAAATATTCTCTTTGTGAAGTTATGCACAGAA
CTGTAACACTTTCCTCTGCCTTTTTCTCTTATATGTGGGTTCATGGTTCAGTTGCATTGTTATGTTATGAATTTACTACTTGGGTGTTCT
AAATACAGTTTATCTTAAAATATGTAGTAATATGAATTCAAAAATGGTTTTTGTTTTAACAATATTAATTAAATTTTCTTGGGTGGATTT
TATAAAAACCTCTGTAAAATCAATTTGTTTACTTATAGTTATCTGGGGTTGTATTGCAAAGAATAGGGTTAATTTTTCTTTTTGTCTTTT
TCTGTCTCTTTCTTAAACTCCCACGCATTGTCCATTTAGAATCTTAGAAAGCTTCTTACCCTCGCTGTCAGTTGGAGGATGAATAATAAA
CATTGTATAATGTTCTTATTCTCGGTTTCTTGTAAGTGGGAAGTCTTTTGAGATCAGCCTTCATATCATACCCTTATTTTGTCTCTCTAG
CATCTTCAGGAACCTGAGTTTGCTTTTTACATAGATCTGATTTTTTCCTTTATTTGGTTTAACATTTTCAAGCATAGATCAGCTTCATGT
ATTTGTTTTATAATTTTGCATCTTAAAGCTAGTAACTAATATTGCTGTGGTCTTATTGGTGAAAACAAAATATAAAATGATAAGAAGACA
TTAAATATTTTACTTTCTATTTCTTACCCTATTGGGAAGAATTTTTAAAAGTTGTAAAATTGACTTAAAGTTAAAATGGTTCTGAATTTG
GTGTTCCATGTCAACTGTTCCCAGTTTTAATTTTAACTTTGCAAAAATAATGTTGTGAAATTCCCTTTAAGTAACTAACACCTAGAAATA
GAGTATCACCAAAAACAAATGTATTTAGGAATCCCAGTTACAATAAAAACTGAAACAGCATGGCTAAGCATCTTAAGGATAATTAAGAAA
TTAGCTTATTTGTATGCTGAACAATGGAATCGAACTTTAATTTAGCATAGTCTTATTAATTTGGAAAATTGTAAAACATCTCAAGAGAGA
AGTTATTAATATTGGTTTATTAATCTTTCTAGAGAAGAAGTGTAGTTATACATTCATTCAGTGCAATCATTTTATAACAGTAGTTAATAT
TTCATTTATAATAGTTCTTAATATACATTTGCTTTCAAATATTCTGAAATGAAATTATATTCATGCTATACCTACAGTGTATGTAAACTA
AAGAGATCACTACATATTTGTTTAATTATTTAAAAAAAAATTTAAGTAAACCCTGTTGTCATTAGCTATTAAGAACATTGATTAAGTCCC
TGGACTTGGATAAACATATATCCTTGAACATATATAATGAAGAAATACAGTGGCTCTTTATTAAAAATAATAGTTGGATAATATAAACTG
AACTATTTATGCATTTTTATATACTTATAAATCCTTCCAAATAGTTTTAATTCTATCCTTTTACATATAAATAACTTAATAAGTGTGCTG
GAAAAACACAGATATTCACAGCACCACTGTTTTTTTTTTTTTTTTGAGATAATAAATTCCATGAGAAATCTGGGTTTGAATATTTGTTTA
CTTTGTCTCCTAATTGAACACCACTCCAGGCCTTCTGTCTGTCTCCCCTTTACCCCCAAAATACTCACAAAAAAATTTTAAGACAACAAG
TAACCATATATAGGTGTTTGAATGATTTTCTCATTTTTATCTAATTTCATTTCATAAGTCCCGAGTAATTTACCTACCATAGGCTACTAT
ACTGATAATATAAATGAAACCGAACATTTTTTGCTACTAACTCTCCCCAATTTAATGTGTTTTCGAAATAAAAATTTAAATTTTTTTCCT
TTTAATTAAAAAGTCATCTTTGAAGTCCTTATTGGCTGTACATTTTACATGTTTGCTGGTACTATTATTTTGTCAGTCAGTTAAAGCTGG
CATGTACAGCTCTTGGCTTTAATGAAAAGCACATTGACATAATGTTAGTAAATTCCAAACCCCGGCACAGAATGTGAGTTAAAATTAAGT
CTTGCTGGGTTAGTGTACAATAAACTATACCTACAGACTTTTTTTTAATAGAAAGAAGACAAAGCTGCTGGTATAGGATTTGTTCCTTTG
AAGAAAAAATGAGGGAAACAAACACAAAAACCTCAATGCAGTGTATAAATAACATTTTGTTCAACTACCTCTTAATGTGGAATTATCTAC
TTTAATAGTTTCCTGACAGTAATGTTAAATAGTAACTGCCAAATTTGTTATTTTCCCATCTCTCTTAAAAAAGTCTTTATGATTATTTTA
TATAGTTTTGAGAACTTTAAAGCCACTTTTTTTTAACCTTACATTTGCATAAAAATGTTTAGCTTTTAAGTAGAGAGCAAATTATGATCA
TATATTTTGATATTCATGACCTGTTTGACTATAGGAGTTTTTTTAAAAAAATGCACTTTGGCTATAAAACCATGGATGATTTGATCCATA
AGATTTAAATGTGCCACCATTATAGTATTCCTAGACATGAGCTTGATGAATGGTATTCTGTAATTATAACGTGCCACACATTATTGTGTC
TTAATTGCCCTTAGCCTGAATTTTAATGATCAATTTGTTATTGTTGCAGATGTGAATATTGTGCATAAACTTACTAAATTTATGTAAAAT
TGTATAAAATAGAATTAGAAGTCACTAAGTTCTTTCTGTGTAGAAGTAATAAATTTATTGTAACACAATGCAGTTGTGTATATGACATTC
TGTAATTCCTTGAACTGGATCATATATTCATAAGTTCTGTAGATACTTATGCATGAACATTTTCTCATTTAGTTTTTGGGTTCATTATTT
GTATTGTGTTTACTACTTGTGATCATGTAGTTGTGCCTTACTTTGTGAGAAAGGTTAGCTCAGTAAATACTGCAATTTCTAAACTCAGTG
ATTGGAAGGTTATTAATTATAAATGTAACTGATAAAGTACGTGACAGCATTTAAATCTGTATAAAGAACAATGGAAGGATCCTTATTGAA
TTGTTGCTTTTTTTTAATATGTTTAAATATTATATTAAAAACATTTCTTTCTAAACTAGTTGTATTCTGTGACTATAAATTGTTTTGTCT
AACAAAAGAGAGAACACTGTATTAACCATTTTGCATTAATTTATTTACAGAATATTAGGACTTTGCACTTGGATATAGACAGTGGTGTTT
TAATGTTGTTCAATTTCGAATAGTAATTAAATTCCTGATCTCAAGAGAAATTATTAATGCCATTTTGCCTTAGACATTCCATTTAATATT
GTAGAGAATTAACAAAACTAAAAACAAATATAAAAAATATGTAATTAACCCCTTATTTCATTGTGTGTCTGCATTTAATACCCAGATGAC
CATTTAAAGATACTTAAAACATTATTTATTTATTTATTTATTTATTTTTCTCCCTCCCCTCCCCAAAGATACTTTTTGGAAGGCCCAATG
TGCCATTGTTTTTTGCTATTTTTTCTTCCTGGGAGCCACGGTTCTAGAATGGTTTTTGTTCTGACCCCCGTGATCCCTTCATTCGAATGT
GCTTCATTCTAAACCCTCCAAAGAGTTTAATGTGCATATCCTCAAACATCTAATATATTGTATATTAGACATGTTACTTTGTGAGCTTTA
TAGAATTCCAGTTTATGTACAGCATATTCTTGAGCTGTTTTATATATTTTGTTAATTTAGTCAGTCTGTCTCTCCCTTTAATGAGATTCA
GAGGGAGAAAACTACCTTTATACATGTAAGTCTGTGGTTGCTGGATTCATGGGACTAAAGGAATTTGAGAGGCCACCTCATCCTAGTCCA
CTGCTCACCTCCGAGGTTAGTTTATATCTAAACATTTGCAAGATGATTGTTAATGTAAAAATTTTTTTTAACCAGAAATTTCTTTATAAA
ATCTTCTCTTGCATAATCTATATTGTATTCTCCTGGACATAACTGCTTTCAGTCCCATCCAGATGCCATCTCTAGGAATTCACTTGAAGC
TTGAAGTCTATTCTCCCCTTTTTCTCCCCTCCACCTCATTTATTCTTAGCTATTAACAATAGTTACTGTCCTCCAGATTTTCCTTTTTTT
CTTCTATTAAATTTCTGACATTATTATAAAGAGGTTATTAGTCTCCATTCTAATAGTGCTTGCCTTGTACAAAAGCCTTTCTGCTGCACT
TGTCTTTACTGCTTTGTTTGCATAGTGAAATTTCACCTTCCTCAAGGAATTACTGGGCACATGACTTGCCCAAACATTATCCTCTCTACC
CCATTCTTCAGCTTAACAAAATCAGCTAAGGCTTCAGTTGTCTTGCAGCCAAATTTGATAAATTTACTACTTTCACTTTGCAAATTGCAA
AAGGTACGATTCTGAAATGGAAGTTTGTGGACTTCCCTTTGATGCAATAATCTGACCCTAAGAACTAGTTCCTTGAATGTAGTTAATAGT
ATATATCCTGCCATGATAATAATTATTCAAACTGCCTTTCATGATAAAAATTCTGAAGAAATTTGAAGTCCTGCCAAATAAAATTAAGTG
ACTGTACTGTGCTAACACACACACACACACACACACACACCAATCAAAACCAGAAAGTATTTTTATGGCAAACACCATCATTCTTCAAAA
AATAAAGTTAAGAGACAGATACCTTACTATGTCTATGAAAATCTGTACACTTCACAACAGGCCAAGAAAAGCCATGCAAAAGTGTTAACT
GGTGAAAGCCAGATTTTTTTTTTCTTCCTATCTTAAAGTAATGGAATTTAGTCTTTGGGATTTTCTACTTCCACGTTAGAGTACTATATA
CCTGAGATGAGTTTGAGAATAGGAATTTTAAAACTGCTACTTAAATGTAGTCCCTATTTATTGCTTTGTATATTAAAAGAACAATCAAGC

>87975_87975_2_SUDS3-EEA1_SUDS3_chr12_118841322_ENST00000543473_EEA1_chr12_93251261_ENST00000322349_length(amino acids)=1325AA_BP=
MLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIK
SKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE
ATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS
ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE
KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK
ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL
NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE
KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE
EEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE
LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV
LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL
IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ
LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE
WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SUDS3-EEA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SUDS3-EEA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SUDS3-EEA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource