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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CREB3L2-GREM1 (FusionGDB2 ID:HG64764TG26585) |
Fusion Gene Summary for CREB3L2-GREM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CREB3L2-GREM1 | Fusion gene ID: hg64764tg26585 | Hgene | Tgene | Gene symbol | CREB3L2 | GREM1 | Gene ID | 64764 | 26585 |
| Gene name | cAMP responsive element binding protein 3 like 2 | gremlin 1, DAN family BMP antagonist | |
| Synonyms | BBF2H7 | C15DUPq|CKTSF1B1|CRAC1|CRCS4|DAND2|DRM|DUP15q|GREMLIN|HMPS|HMPS1|IHG-2|MPSH|PIG2 | |
| Cytomap | ('CREB3L2')('GREM1') 7q33 | 15q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclic AMP-responsive element-binding protein 3-like protein 2B-ZIB transcription factorBBF2 human homolog on chromosome 7FUS/BBF2H7 proteinTCAG_1951439basic transcription factor 2cAMP-responsive element-binding protein 3-like protein 2 | gremlin-1DAN domain family member 2cell proliferation-inducing gene 2 proteincolorectal adenoma and carcinoma 1cysteine knot superfamily 1, BMP antagonist 1down-regulated in Mos-transformed cells proteingremlin 1, cysteine knot superfamily, homolog | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q70SY1 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000330387, ENST00000452463, ENST00000456390, ENST00000468127, ENST00000458726, | ||
| Fusion gene scores | * DoF score | 15 X 16 X 7=1680 | 1 X 1 X 1=1 |
| # samples | 18 | 1 | |
| ** MAII score | log2(18/1680*10)=-3.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CREB3L2 [Title/Abstract] AND GREM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CREB3L2(137686350)-GREM1(33022891), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CREB3L2 | GO:0045893 | positive regulation of transcription, DNA-templated | 17178827 |
| Tgene | GREM1 | GO:0000902 | cell morphogenesis | 16545136 |
| Tgene | GREM1 | GO:0008284 | positive regulation of cell proliferation | 16545136 |
| Tgene | GREM1 | GO:0030514 | negative regulation of BMP signaling pathway | 15539560 |
| Tgene | GREM1 | GO:0051973 | positive regulation of telomerase activity | 16545136 |
| Tgene | GREM1 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation | 15539560 |
| Tgene | GREM1 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 15539560 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8077-01A | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
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Fusion Gene ORF analysis for CREB3L2-GREM1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000330387 | ENST00000300177 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000330387 | ENST00000322805 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000330387 | ENST00000560677 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000330387 | ENST00000560830 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000452463 | ENST00000300177 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000452463 | ENST00000322805 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000452463 | ENST00000560677 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000452463 | ENST00000560830 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000456390 | ENST00000300177 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000456390 | ENST00000322805 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000456390 | ENST00000560677 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5CDS-5UTR | ENST00000456390 | ENST00000560830 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5UTR-5UTR | ENST00000468127 | ENST00000300177 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5UTR-5UTR | ENST00000468127 | ENST00000322805 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5UTR-5UTR | ENST00000468127 | ENST00000560677 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| 5UTR-5UTR | ENST00000468127 | ENST00000560830 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| intron-5UTR | ENST00000458726 | ENST00000300177 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| intron-5UTR | ENST00000458726 | ENST00000322805 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| intron-5UTR | ENST00000458726 | ENST00000560677 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| intron-5UTR | ENST00000458726 | ENST00000560830 | CREB3L2 | chr7 | 137686350 | - | GREM1 | chr15 | 33022891 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CREB3L2-GREM1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| CREB3L2 | chr7 | 137686349 | - | GREM1 | chr15 | 33022891 | + | 2.21E-05 | 0.9999778 |
| CREB3L2 | chr7 | 137686349 | - | GREM1 | chr15 | 33022891 | + | 2.21E-05 | 0.9999778 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CREB3L2-GREM1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:137686350/:33022891) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CREB3L2 | . |
| FUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CREB3L2-GREM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for CREB3L2-GREM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CREB3L2-GREM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CREB3L2-GREM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C1832587 | POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 | 8 | CLINGEN;GENOMICS_ENGLAND;ORPHANET | |
| Tgene | C0009402 | Colorectal Carcinoma | 2 | CTD_human | |
| Tgene | C0009404 | Colorectal Neoplasms | 2 | CTD_human | |
| Tgene | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human | |
| Tgene | C0032580 | Adenomatous Polyposis Coli | 1 | CTD_human | |
| Tgene | C0034069 | Pulmonary Fibrosis | 1 | CTD_human | |
| Tgene | C0038356 | Stomach Neoplasms | 1 | CTD_human | |
| Tgene | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human | |
| Tgene | C2677290 | COLORECTAL CANCER, SUSCEPTIBILITY TO, 4 | 1 | ORPHANET | |
| Tgene | C2677291 | COLORECTAL CANCER, SUSCEPTIBILITY TO, ON CHROMOSOME 15 | 1 | ORPHANET | |
| Tgene | C2713442 | Polyposis, Adenomatous Intestinal | 1 | CTD_human | |
| Tgene | C2713443 | Familial Intestinal Polyposis | 1 | CTD_human | |
| Tgene | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |
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