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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP85-STX12 (FusionGDB2 ID:HG64793TG23673)

Fusion Gene Summary for CEP85-STX12

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP85-STX12
Fusion gene ID: hg64793tg23673
HgeneTgene
Gene symbol

CEP85

STX12

Gene ID

64793

23673

Gene namecentrosomal protein 85syntaxin 12
SynonymsCCDC21STX13|STX14
Cytomap('CEP85')('STX12')

1p36.11

1p35.3

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 85 kDacentrosomal protein 85kDacoiled-coil domain-containing protein 21syntaxin-12
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000252992, ENST00000451429, 
ENST00000469609, 
Fusion gene scores* DoF score5 X 4 X 5=1006 X 7 X 4=168
# samples 57
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP85 [Title/Abstract] AND STX12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP85(26566329)-STX12(28116073), # samples:2
Anticipated loss of major functional domain due to fusion event.CEP85-STX12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP85-STX12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP85-STX12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CEP85-STX12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTX12

GO:0033344

cholesterol efflux

15469992

TgeneSTX12

GO:0050821

protein stabilization

15469992


check buttonFusion gene breakpoints across CEP85 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across STX12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AZ-4614-01ACEP85chr1

26566329

-STX12chr1

28116073

+
ChimerDB4COADTCGA-AZ-4614-01ACEP85chr1

26566329

+STX12chr1

28116073

+


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Fusion Gene ORF analysis for CEP85-STX12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000252992ENST00000468761CEP85chr1

26566329

+STX12chr1

28116073

+
5CDS-3UTRENST00000451429ENST00000468761CEP85chr1

26566329

+STX12chr1

28116073

+
In-frameENST00000252992ENST00000373943CEP85chr1

26566329

+STX12chr1

28116073

+
In-frameENST00000451429ENST00000373943CEP85chr1

26566329

+STX12chr1

28116073

+
intron-3CDSENST00000469609ENST00000373943CEP85chr1

26566329

+STX12chr1

28116073

+
intron-3UTRENST00000469609ENST00000468761CEP85chr1

26566329

+STX12chr1

28116073

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000451429CEP85chr126566329+ENST00000373943STX12chr128116073+3024188130900256
ENST00000252992CEP85chr126566329+ENST00000373943STX12chr128116073+3022186128898256

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000451429ENST00000373943CEP85chr126566329+STX12chr128116073+0.000344040.99965596
ENST00000252992ENST00000373943CEP85chr126566329+STX12chr128116073+0.0003457570.9996543

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Fusion Genomic Features for CEP85-STX12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CEP85chr126566329+STX12chr128116072+2.35E-060.9999976
CEP85chr126566329+STX12chr128116072+2.35E-060.9999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CEP85-STX12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:26566329/chr1:28116073)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTX12chr1:26566329chr1:28116073ENST0000037394309178_24039277.0Domaint-SNARE coiled-coil homology
TgeneSTX12chr1:26566329chr1:28116073ENST0000037394309270_27639277.0Topological domainVesicular
TgeneSTX12chr1:26566329chr1:28116073ENST0000037394309249_26939277.0TransmembraneHelical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP85chr1:26566329chr1:28116073ENST00000252992+214334_65718763.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85chr1:26566329chr1:28116073ENST00000252992+214723_75018763.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85chr1:26566329chr1:28116073ENST00000252992+214434_47618763.0RegionRequired for centrosome localization and for its function in the suppression of centrosome disjunction
TgeneSTX12chr1:26566329chr1:28116073ENST000003739430933_13139277.0Coiled coilOntology_term=ECO:0000255
TgeneSTX12chr1:26566329chr1:28116073ENST00000373943092_24839277.0Topological domainCytoplasmic


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Fusion Gene Sequence for CEP85-STX12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15922_15922_1_CEP85-STX12_CEP85_chr1_26566329_ENST00000252992_STX12_chr1_28116073_ENST00000373943_length(transcript)=3022nt_BP=186nt
GCAACGGCCGTTAGAGGAGCTGAGGGAGGGAACCACCGCTCACCGCAGACGTGGTGGCTGCAGTCAGTCTTCCCGAGTGAGGGATTTCGC
CGCCCGCTTTCAGGCCCGTTTGGCTTAAATAACTGTGATTGATGGCCATGCAGGAGAAATATCCAACTGAGGGGATCTCTCACGTCACTT
CACCGACTGCTCAGATAAAGAATTTGATGAGCCAGCTAGGAACTAAGCAGGACTCAAGCAAGCTACAGGAAAATCTGCAACAGTTACAAC
ACTCCACAAATCAGCTCGCCAAGGAAACAAATGAATTGCTGAAAGAATTAGGGTCCTTGCCCCTTCCCTTATCTACTTCAGAACAGCGCC
AGCAGAGACTTCAGAAGGAACGCCTCATGAATGACTTCTCTGCAGCCTTAAACAATTTCCAGGCTGTGCAGAGAAGGGTATCTGAAAAGG
AAAAGGAGAGTATTGCCAGAGCAAGAGCTGGATCTCGTCTTTCTGCAGAAGAGAGGCAAAGAGAGGAGCAGCTGGTCTCATTTGACAGCC
ATGAGGAGTGGAACCAGATGCAGAGCCAGGAGGATGAGGTGGCCATCACTGAGCAGGATTTGGAACTTATTAAAGAAAGAGAAACGGCAA
TTCGGCAGCTGGAGGCTGACATTTTGGATGTCAATCAGATATTTAAAGATTTGGCCATGATGATCCATGACCAGGGTGATCTGATTGATA
GCATAGAAGCCAATGTGGAAAGCTCAGAGGTGCACGTCGAAAGAGCCACTGAACAGTTACAGCGAGCTGCTTACTATCAGAAAAAATCTC
GCAAGAAGATGTGTATCCTGGTGCTTGTCCTGTCAGTGATTATTCTAATCTTGGGACTTATTATCTGGCTAGTTTATAAAACGAAGTGAT
TGCCTCCGATCGTTCTCCCGCTGAGCTGTTTTCAAGGGCAAGTGCTTGTTGAAGTCTTGCCAGAACAAACTGATCACAAGAAGACAGCAT
ATATCAGAACGTCCTGTAATCATTTAGTTAGAAACTAACTACTAACTAGTCTTTGGAATTCGTGACCTATGGAGACAGTAATTATCAATT
TATTGATTCTATTGATTTCTCAAATTAGGAATTAACTTATGTGGATTTTGCTTCCTCTTGTATTCTGATTGCCCTTCATCCCAAGTGTTT
ACTGAAAATTCCATTCTAGATATTCTTGTTTTGACAAATGACACTACAGTCTCGTAATATTGTCTTTTATGTATATACAAAATTTACCTT
TTTACTAGCATCTGAGATAGAGTTACTTTCTGGTACCCAGTATATTGGAGTCTGTCAGAAACTCTATAATAGGCCACCAGTTTTTATTAT
TTAACATTTTTATTTGAATTTCTAAGAAGCCTATTCTCTATCTATTTTGAAAGATTTTGGCACTATATTTAATTGGAAGGTAAAATATTG
TACATGTGATCCAGAGTAAATGAGAAGTCTCTATCTGAGCTGGTCAGTTACTGGAGTACATGTTACTAATCTGGGTTTAAAGTTTACTTC
ATTATCTGCTAGTGTCATCCACAGCAGTTCATCCTCATCCACACTAAGCCATCCTGTTAGCTTTTAAAGGAAGTTAATTTAATTAACATT
AATATACTCTATGGGCTCCCTCTCCCACCTGTCTGCATAGAAAGGCAGAATTAGACATAGCATGCTTTGGAAAAGCAAATAGGAATTGTT
GGGAATGATTTAATCTTGTTGTTGTTGTTGTTGTTGTTCACTTGTGGTTCTACATTCCTGGTGAATGATGAATGTTGCTGTCAAAGGGCT
GCCCCCTACCTTATAAGGGTTGCTGGGCATTTGAAGGCAGGAAGATTTTTAAAGATAGATTGAGGTTGGTTTAAAATTATTCCTGTAAAC
CAACAATAAAGCAAAGAAGAGGTTCATTTTTGTAAATAACACTGGTTTCAAATAGTGATGTTAGACTTAACCTAATTTATAAACAAGAGA
TTAATATCTCCATGCATAGTTTTAGACAAAAAAAGATGTTTCAATAAAATTACTGTCTTGTAATATAAATGTTGTCCACTTCCCTTTTCC
ACAGGCCTAGAACAGTTAAAGGGAACATAATTTGTTTAGGCTCCCACATAAATGTGAATCTGGCCAACAACTTTGGTTCATCCTTTAGTG
AATTAGAGGATTTGGCTACCCTGAGTATATTTATATTCATTTCTTCTGTTCTCCTTCTGTTATTATACTTAATCTTCTAAACTAAACTAA
TGTGAACAGTAGGGAAGCAAGGGCCCAAATGCATAAGTTTCTTTGCACTGTTGCACTTACTTAATACAAATAAATGTTTTTTAAAGCTTT
TGTAGTATGTTTTTATGAGTTAACATCCTAATGTGGTAGGTATTAGGTAATGTGCTGTCATGAGAAAAATTGAGACTTCCAAGAAAACTG
GACACCAGGTGAGGGTTGGTTTGGAGACGGAATAGGTGTAGCTGCCTTTCCTTGAAAAACAGTGTGTAGAGATGGCTGAGTGCAATGGCT
CACACTTGTAATCCCAACACTTTGGAAGGCTGAGGCGGGAGGATCAGTATATCGGTACGTCTGAGCCCAAGAGTTCAAGATCAGCCTGGG
CAGTATAGCAAGACCCCATCTCCATTTTTTTTTTAATGATTTTTTAATTAAAAAAAAGAACAACAGGATAGAGCTGTTGGGGTGGCACAG
TGGCCCAAAGAGCAGCTTCAGAGATAATTCCTTGGTTCTATGATCCCTGTTTAACTCCAAATTACAGTCGGACTTGGATACATCATTTGT
AACATTGTAGGAAAGAAAAAAGTCTTGGTTGTGAAAAACGATTTGCATTTGGGTAAAATAAAGTGACCATGCTTTTGTTCTGTAATACTG
TGTGACCTGTGGTTGTTGTAATGGTGATCATGGAGAGCAAATATGAACTTGGCCTGGATTTTAAATGGCCTAGAATTTGTGGTAGTTGCC

>15922_15922_1_CEP85-STX12_CEP85_chr1_26566329_ENST00000252992_STX12_chr1_28116073_ENST00000373943_length(amino acids)=256AA_BP=17
MMAMQEKYPTEGISHVTSPTAQIKNLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQRLQKERLMNDF
SAALNNFQAVQRRVSEKEKESIARARAGSRLSAEERQREEQLVSFDSHEEWNQMQSQEDEVAITEQDLELIKERETAIRQLEADILDVNQ

--------------------------------------------------------------
>15922_15922_2_CEP85-STX12_CEP85_chr1_26566329_ENST00000451429_STX12_chr1_28116073_ENST00000373943_length(transcript)=3024nt_BP=188nt
GTGCAACGGCCGTTAGAGGAGCTGAGGGAGGGAACCACCGCTCACCGCAGACGTGGTGGCTGCAGTCAGTCTTCCCGAGTGAGGGATTTC
GCCGCCCGCTTTCAGGCCCGTTTGGCTTAAATAACTGTGATTGATGGCCATGCAGGAGAAATATCCAACTGAGGGGATCTCTCACGTCAC
TTCACCGACTGCTCAGATAAAGAATTTGATGAGCCAGCTAGGAACTAAGCAGGACTCAAGCAAGCTACAGGAAAATCTGCAACAGTTACA
ACACTCCACAAATCAGCTCGCCAAGGAAACAAATGAATTGCTGAAAGAATTAGGGTCCTTGCCCCTTCCCTTATCTACTTCAGAACAGCG
CCAGCAGAGACTTCAGAAGGAACGCCTCATGAATGACTTCTCTGCAGCCTTAAACAATTTCCAGGCTGTGCAGAGAAGGGTATCTGAAAA
GGAAAAGGAGAGTATTGCCAGAGCAAGAGCTGGATCTCGTCTTTCTGCAGAAGAGAGGCAAAGAGAGGAGCAGCTGGTCTCATTTGACAG
CCATGAGGAGTGGAACCAGATGCAGAGCCAGGAGGATGAGGTGGCCATCACTGAGCAGGATTTGGAACTTATTAAAGAAAGAGAAACGGC
AATTCGGCAGCTGGAGGCTGACATTTTGGATGTCAATCAGATATTTAAAGATTTGGCCATGATGATCCATGACCAGGGTGATCTGATTGA
TAGCATAGAAGCCAATGTGGAAAGCTCAGAGGTGCACGTCGAAAGAGCCACTGAACAGTTACAGCGAGCTGCTTACTATCAGAAAAAATC
TCGCAAGAAGATGTGTATCCTGGTGCTTGTCCTGTCAGTGATTATTCTAATCTTGGGACTTATTATCTGGCTAGTTTATAAAACGAAGTG
ATTGCCTCCGATCGTTCTCCCGCTGAGCTGTTTTCAAGGGCAAGTGCTTGTTGAAGTCTTGCCAGAACAAACTGATCACAAGAAGACAGC
ATATATCAGAACGTCCTGTAATCATTTAGTTAGAAACTAACTACTAACTAGTCTTTGGAATTCGTGACCTATGGAGACAGTAATTATCAA
TTTATTGATTCTATTGATTTCTCAAATTAGGAATTAACTTATGTGGATTTTGCTTCCTCTTGTATTCTGATTGCCCTTCATCCCAAGTGT
TTACTGAAAATTCCATTCTAGATATTCTTGTTTTGACAAATGACACTACAGTCTCGTAATATTGTCTTTTATGTATATACAAAATTTACC
TTTTTACTAGCATCTGAGATAGAGTTACTTTCTGGTACCCAGTATATTGGAGTCTGTCAGAAACTCTATAATAGGCCACCAGTTTTTATT
ATTTAACATTTTTATTTGAATTTCTAAGAAGCCTATTCTCTATCTATTTTGAAAGATTTTGGCACTATATTTAATTGGAAGGTAAAATAT
TGTACATGTGATCCAGAGTAAATGAGAAGTCTCTATCTGAGCTGGTCAGTTACTGGAGTACATGTTACTAATCTGGGTTTAAAGTTTACT
TCATTATCTGCTAGTGTCATCCACAGCAGTTCATCCTCATCCACACTAAGCCATCCTGTTAGCTTTTAAAGGAAGTTAATTTAATTAACA
TTAATATACTCTATGGGCTCCCTCTCCCACCTGTCTGCATAGAAAGGCAGAATTAGACATAGCATGCTTTGGAAAAGCAAATAGGAATTG
TTGGGAATGATTTAATCTTGTTGTTGTTGTTGTTGTTGTTCACTTGTGGTTCTACATTCCTGGTGAATGATGAATGTTGCTGTCAAAGGG
CTGCCCCCTACCTTATAAGGGTTGCTGGGCATTTGAAGGCAGGAAGATTTTTAAAGATAGATTGAGGTTGGTTTAAAATTATTCCTGTAA
ACCAACAATAAAGCAAAGAAGAGGTTCATTTTTGTAAATAACACTGGTTTCAAATAGTGATGTTAGACTTAACCTAATTTATAAACAAGA
GATTAATATCTCCATGCATAGTTTTAGACAAAAAAAGATGTTTCAATAAAATTACTGTCTTGTAATATAAATGTTGTCCACTTCCCTTTT
CCACAGGCCTAGAACAGTTAAAGGGAACATAATTTGTTTAGGCTCCCACATAAATGTGAATCTGGCCAACAACTTTGGTTCATCCTTTAG
TGAATTAGAGGATTTGGCTACCCTGAGTATATTTATATTCATTTCTTCTGTTCTCCTTCTGTTATTATACTTAATCTTCTAAACTAAACT
AATGTGAACAGTAGGGAAGCAAGGGCCCAAATGCATAAGTTTCTTTGCACTGTTGCACTTACTTAATACAAATAAATGTTTTTTAAAGCT
TTTGTAGTATGTTTTTATGAGTTAACATCCTAATGTGGTAGGTATTAGGTAATGTGCTGTCATGAGAAAAATTGAGACTTCCAAGAAAAC
TGGACACCAGGTGAGGGTTGGTTTGGAGACGGAATAGGTGTAGCTGCCTTTCCTTGAAAAACAGTGTGTAGAGATGGCTGAGTGCAATGG
CTCACACTTGTAATCCCAACACTTTGGAAGGCTGAGGCGGGAGGATCAGTATATCGGTACGTCTGAGCCCAAGAGTTCAAGATCAGCCTG
GGCAGTATAGCAAGACCCCATCTCCATTTTTTTTTTAATGATTTTTTAATTAAAAAAAAGAACAACAGGATAGAGCTGTTGGGGTGGCAC
AGTGGCCCAAAGAGCAGCTTCAGAGATAATTCCTTGGTTCTATGATCCCTGTTTAACTCCAAATTACAGTCGGACTTGGATACATCATTT
GTAACATTGTAGGAAAGAAAAAAGTCTTGGTTGTGAAAAACGATTTGCATTTGGGTAAAATAAAGTGACCATGCTTTTGTTCTGTAATAC
TGTGTGACCTGTGGTTGTTGTAATGGTGATCATGGAGAGCAAATATGAACTTGGCCTGGATTTTAAATGGCCTAGAATTTGTGGTAGTTG

>15922_15922_2_CEP85-STX12_CEP85_chr1_26566329_ENST00000451429_STX12_chr1_28116073_ENST00000373943_length(amino acids)=256AA_BP=17
MMAMQEKYPTEGISHVTSPTAQIKNLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQRLQKERLMNDF
SAALNNFQAVQRRVSEKEKESIARARAGSRLSAEERQREEQLVSFDSHEEWNQMQSQEDEVAITEQDLELIKERETAIRQLEADILDVNQ

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Fusion Gene PPI Analysis for CEP85-STX12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP85-STX12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP85-STX12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource