Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SKIV2L-ABCA8 (FusionGDB2 ID:HG6499TG10351)

Fusion Gene Summary for SKIV2L-ABCA8

check button Fusion gene summary
Fusion gene informationFusion gene name: SKIV2L-ABCA8
Fusion gene ID: hg6499tg10351
HgeneTgene
Gene symbol

SKIV2L

ABCA8

Gene ID

6499

10351

Gene nameSki2 like RNA helicaseATP binding cassette subfamily A member 8
Synonyms170A|DDX13|HLP|SKI2|SKI2W|SKIV2|SKIV2L1|THES2-
Cytomap('SKIV2L')('ABCA8')

6p21.33

17q24.2

Type of geneprotein-codingprotein-coding
Descriptionhelicase SKI2WSKI2 homolog, superkiller viralicidic activity 2-likehelicase-like proteinsuperkiller viralicidic activity 2-likeATP-binding cassette sub-family A member 8ATP-binding cassette, sub-family A (ABC1), member 8
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000375394, ENST00000544581, 
ENST00000383336, ENST00000412823, 
ENST00000421789, ENST00000429465, 
ENST00000448219, ENST00000461360, 
ENST00000466463, ENST00000471547, 
ENST00000476338, ENST00000480914, 
ENST00000488648, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 2 X 2=12
# samples 63
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SKIV2L [Title/Abstract] AND ABCA8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSKIV2L(31934591)-ABCA8(66864316), # samples:1
Anticipated loss of major functional domain due to fusion event.SKIV2L-ABCA8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SKIV2L-ABCA8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SKIV2L-ABCA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SKIV2L-ABCA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SKIV2L-ABCA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SKIV2L-ABCA8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SKIV2L-ABCA8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SKIV2L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ABCA8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


Top

Fusion Gene ORF analysis for SKIV2L-ABCA8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375394ENST00000269080SKIV2Lchr631934591+ABCA8chr1766864316-0.0010927140.9989073
ENST00000544581ENST00000269080SKIV2Lchr631934591+ABCA8chr1766864316-0.0019459090.99805415

Top

Fusion Genomic Features for SKIV2L-ABCA8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for SKIV2L-ABCA8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:31934591/chr17:66864316)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCA8chr6:31934591chr17:66864316ENST000002690800381285_151801582.0DomainABC transporter 2
TgeneABCA8chr6:31934591chr17:66864316ENST00000269080038480_71501582.0DomainABC transporter 1
TgeneABCA8chr6:31934591chr17:66864316ENST000004303520381285_151801622.0DomainABC transporter 2
TgeneABCA8chr6:31934591chr17:66864316ENST00000430352038480_71501622.0DomainABC transporter 1
TgeneABCA8chr6:31934591chr17:66864316ENST000002690800381323_133001582.0Nucleotide bindingATP 2
TgeneABCA8chr6:31934591chr17:66864316ENST00000269080038516_52301582.0Nucleotide bindingATP 1
TgeneABCA8chr6:31934591chr17:66864316ENST000004303520381323_133001622.0Nucleotide bindingATP 2
TgeneABCA8chr6:31934591chr17:66864316ENST00000430352038516_52301622.0Nucleotide bindingATP 1
TgeneABCA8chr6:31934591chr17:66864316ENST000002690800381019_103901582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000002690800381070_109001582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000002690800381106_112601582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000002690800381136_115601582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000002690800381161_118101582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000002690800381197_121701582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000269080038220_24001582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000269080038268_28801582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000269080038299_31901582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST0000026908003830_5001582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000269080038327_34701582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000269080038359_37901582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000269080038397_41701582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000269080038864_88401582.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000004303520381019_103901622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000004303520381070_109001622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000004303520381106_112601622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000004303520381136_115601622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000004303520381161_118101622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST000004303520381197_121701622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000430352038220_24001622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000430352038268_28801622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000430352038299_31901622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST0000043035203830_5001622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000430352038327_34701622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000430352038359_37901622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000430352038397_41701622.0TransmembraneHelical
TgeneABCA8chr6:31934591chr17:66864316ENST00000430352038864_88401622.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000375394+128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000375394+128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000383336+128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000383336+128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000412823+128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000412823+128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000421789+128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000421789+128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000429465+128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000429465+128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000448219+128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000448219+128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000375394+128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000383336+128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000412823+128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000421789+128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000429465+128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000448219+128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000375394+128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000383336+128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000412823+128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000421789+128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000429465+128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31934591chr17:66864316ENST00000448219+128332_33901247.0Nucleotide bindingATP


Top

Fusion Gene Sequence for SKIV2L-ABCA8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82142_82142_1_SKIV2L-ABCA8_SKIV2L_chr6_31934591_ENST00000375394_ABCA8_chr17_66864316_ENST00000269080_length(transcript)=3231nt_BP=2347nt
GGCGGGGCTGTACCGGAAGTTGCCTCTACTTCCGCCCGTTCCGGGGCGGGGCTTACTTCGCAGCGACTACTTGCCGCACTTCCGGGCTGC
CAGGCAGCTGCTGTGGCTCCAGGATGATGGAGACAGAGCGACTTGTGCTACCCCCTCCAGATCCCCTGGACCTACCCCTTCGGGCCGTGG
AGCTCGGATGCACGGGGCACTGGGAGCTGCTGAACTTGCCTGGAGCTCCAGAGAGTAGCCTTCCCCATGGCCTCCCTCCTTGTGCCCCAG
ATCTGCAGCAAGAAGCAGAACAGTTGTTTCTGTCATCCCCAGCCTGGCTGCCTCTGCATGGTGTGGAGCACTCAGCCCGAAAATGGCAGA
GGAAGACGGATCCCTGGTCTCTTTTGGCTGTCCTGGGAGCCCCAGTCCCATCCGACCTACAGGCCCAAAGACACCCAACCACAGGCCAGA
TACTGGGTTACAAAGAGGTCTTGCTGGAGAACACAAATCTCTCGGCTACAACCTCCTTGTCTCTTCGCCGGCCTCCAGGGCCAGCCTCCC
AGTCCTTATGGGGAAATCCAACTCAGTATCCCTTCTGGCCAGGGGGGATGGATGAACCCACCATAACAGATCTGAACACACGGGAGGAGG
CTGAGGAGGAGATAGACTTTGAGAAAGATCTTCTTACTATTCCACCTGGTTTCAAGAAAGGCATGGACTTTGCACCAAAAGATTGTCCAA
CTCCAGCTCCTGGACTACTAAGCCTTAGCTGTATGTTGGAGCCTCTGGATTTGGGTGGGGGTGACGAGGATGAGAATGAGGCAGTGGGAC
AGCCAGGAGGTCCCAGAGGGGACACTGTTTCAGCCTCTCCCTGCAGTGCTCCCCTGGCCCGAGCAAGCAGCTTGGAAGACCTAGTGTTGA
AGGAAGCGTCCACAGCTGTATCCACCCCAGAGGCCCCAGAGCCTCCATCTCAGGAGCAGTGGGCCATCCCTGTGGACGCCACCTCCCCTG
TTGGTGATTTCTATCGCCTCATTCCCCAGCCAGCCTTCCAGTGGGCATTTGAGCCAGATGTGTTTCAGAAACAGGCCATCCTGCACTTGG
AACGGCATGACTCTGTCTTTGTCGCAGCTCACACATCTGCAGGAAAAACAGTTGTGGCTGAATATGCCATTGCCCTGGCCCAGAAACACA
TGACACGCACCATCTACACTTCGCCCATCAAGGCCCTGAGCAACCAGAAGTTCCGGGACTTCCGAAACACATTCGGGGATGTGGGGCTGC
TCACCGGGGATGTACAGCTGCATCCGGAGGCCTCCTGCCTCATCATGACCACAGAGATCCTTCGCTCCATGCTGTACAGTGGCTCAGATG
TTATTCGGGACCTGGAGTGGGTCATCTTTGATGAGGTTCACTATATCAACGATGTCGAGCGTGGGGTCGTGTGGGAGGAGGTGCTTATCA
TGCTACCTGACCACGTTTCTATCATCCTTCTGAGTGCCACCGTCCCCAACGCCCTTGAGTTTGCTGACTGGATTGGGCGGCTGAAGCGTC
GTCAGATCTATGTGATTAGCACTGTAACCCGCCCCGTGCCCCTGGAGCACTATCTTTTCACAGGGAACAGCTCCAAGACCCAGGGGGAGC
TCTTTTTGTTGCTGGACTCCCGAGGAGCCTTCCATACAAAAGGGTACTATGCAGCTGTGGAGGCCAAGAAGGAGAGAATGAGCAAACACG
CCCAGACCTTTGGGGCCAAGCAGCCCACACATCAGGGGGGCCCTGCACAGGACCGCGGAGTGTACCTGTCCCTCCTGGCCTCCCTCCGCA
CACGTGCCCAGTTGCCCGTGGTGGTGTTCACCTTCTCCCGGGGCCGCTGTGATGAGCAGGCCTCAGGCCTCACCTCCCTTGACCTCACCA
CCAGTTCGGAGAAGAGCGAGATCCACCTCTTCCTGCAGCGCTGCCTTGCTCGCCTCCGTGGCTCTGACCGCCAGCTGCCCCAGGTCCTGC
ACATGTCAGAGCTCCTGAATCGCGGCCTGGGTGTGCACCATAGCGGCATCCTGCCCATCCTCAAGGAGATCGTGGAGATGCTCTTCAGCC
GTGGCCTGGTCAAGGTCTTGTTTGCCACAGAGACCTTTGCCATGGGAGTAAACATGCCTGCTCGTACAGTAGTGTTTGACTCCATGCGCA
AACACGATGGCTCCACCTTCCGGGACCTGCTCCCTGGGGAGTATGTGCAGATGGCAGGCCGGGCAGGGCGGAGGGGCCTGGACCCCACAG
GCACCGTTATCCTGCTCTGCAAGGGCCGAGTGCCCGAGATGGCAGACCTGCACCGCATGATGATGTCTCTGAGTTTCCCTCCCGCAAAGA
CAGCAAGGGAGCTCTCCAAGGAGCAGGAGCTGGGTGATTTTGAGGAGGATTTTGATCCCTCAGTGAAGTGGAAGCTCCTCCCCCAGGAAG
AGCCTTAAAACCCCAAATTCTGTGTTCCTGTTTAAACCCGTGGTTTTTTTTAAATACATTTATTTTTATAGCAGCAATGTTCTATTTTTA
GAAACTATATTATAAGTACAGAAATGGTTCTCCGTGTGGTGGGAGGAGGAGGTTCGGGTGCTGGGTAAGTGCCATGTCAGTGTGGACAGA
GGCATTTGACTAAGCCAACCTCCTCTCACAGCCTCTGTATCTCTGCAGGCCATACTGGTTCCATTGTTCTGTATAATACTGAATAAATAA
ATTTACTTTTACATGATCGTATAAGTTTCTAGATAAGATAAACAAATTTTGTTTAAATTTTTTTAATAAAAATCTTAAAACACTTTTTTT
CTAACCTAGACTGAGAAATTCATGTTTACTTTTCTAGGTGTATGATACTTTGTAAAGTTGATACTTTCCTAAGAATTTAACATGTCATAT
TTTTGAAATAGATTTAAGTGTGCTTCTTATTGCTAAAAATACTAAATGTCATGGGTCATAGTATCTGATATCAATATCGTTGATAACATA
TCCACAGGTAACACCATGATGTAGGCATAAATGGAAAACAAAAACCCTACTATTTCAAATATATTGTACTTTTTTATTTCTGTAAGCCAA
CTGTGTGCCATTTTCACTGGACTTTTAAATCTAGACTTTAGTGATGTCTACATTGTAAATGATCTTTTGTGGATATTTGTCACTTGGTTT

>82142_82142_1_SKIV2L-ABCA8_SKIV2L_chr6_31934591_ENST00000375394_ABCA8_chr17_66864316_ENST00000269080_length(amino acids)=783AA_BP=754
MPGSCCGSRMMETERLVLPPPDPLDLPLRAVELGCTGHWELLNLPGAPESSLPHGLPPCAPDLQQEAEQLFLSSPAWLPLHGVEHSARKW
QRKTDPWSLLAVLGAPVPSDLQAQRHPTTGQILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPTITDLNTRE
EAEEEIDFEKDLLTIPPGFKKGMDFAPKDCPTPAPGLLSLSCMLEPLDLGGGDEDENEAVGQPGGPRGDTVSASPCSAPLARASSLEDLV
LKEASTAVSTPEAPEPPSQEQWAIPVDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQK
HMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDVERGVVWEEVL
IMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSK
HAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQV
LHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDP

--------------------------------------------------------------
>82142_82142_2_SKIV2L-ABCA8_SKIV2L_chr6_31934591_ENST00000544581_ABCA8_chr17_66864316_ENST00000269080_length(transcript)=2722nt_BP=1838nt
AGGCAGCTGCTGTGGCTCCAGGATGATGGAGACAGAGCGACTTGTGCTACCCCCTCCAGATCCCCTGGACCTACCCCTTCGGGCCGTGGA
GCTCGGATGCACGGGGCACTGGGAGCTGCTGAACTTGCCTGGAGCTCCAGAGAGTAGCATCTTCTTACTATTCCACCTGGTTTCAAGAAA
GGCATGGACTTTGCACCAAAAGATTGTCCAACTCCAGCTCCTGGACTACTAAGCCTTAGCTGTATGTTGGAGCCTCTGGATTTGGGTGGG
GGTGACGAGGATGAGAATGAGGCAGTGGGACAGCCAGGAGGTCCCAGAGGGGACACTGTTTCAGCCTCTCCCTGCAGTGCTCCCCTGGCC
CGAGCAAGCAGCTTGGAAGACCTAGTGTTGAAGGAAGCGTCCACAGCTGTATCCACCCCAGAGGCCCCAGAGCCTCCATCTCAGGAGCAG
TGGGCCATCCCTGTGGACGCCACCTCCCCTGTTGGTGATTTCTATCGCCTCATTCCCCAGCCAGCCTTCCAGTGGGCATTTGAGCCAGAT
GTGTTTCAGAAACAGGCCATCCTGCACTTGGAACGGCATGACTCTGTCTTTGTCGCAGCTCACACATCTGCAGGAAAAACAGTTGTGGCT
GAATATGCCATTGCCCTGGCCCAGAAACACATGACACGCACCATCTACACTTCGCCCATCAAGGCCCTGAGCAACCAGAAGTTCCGGGAC
TTCCGAAACACATTCGGGGATGTGGGGCTGCTCACCGGGGATGTACAGCTGCATCCGGAGGCCTCCTGCCTCATCATGACCACAGAGATC
CTTCGCTCCATGCTGTACAGTGGCTCAGATGTTATTCGGGACCTGGAGTGGGTCATCTTTGATGAGGTTCACTATATCAACGATGTCGAG
CGTGGGGTCGTGTGGGAGGAGGTGCTTATCATGCTACCTGACCACGTTTCTATCATCCTTCTGAGTGCCACCGTCCCCAACGCCCTTGAG
TTTGCTGACTGGATTGGGCGGCTGAAGCGTCGTCAGATCTATGTGATTAGCACTGTAACCCGCCCCGTGCCCCTGGAGCACTATCTTTTC
ACAGGGAACAGCTCCAAGACCCAGGGGGAGCTCTTTTTGTTGCTGGACTCCCGAGGAGCCTTCCATACAAAAGGGTACTATGCAGCTGTG
GAGGCCAAGAAGGAGAGAATGAGCAAACACGCCCAGACCTTTGGGGCCAAGCAGCCCACACATCAGGGGGGCCCTGCACAGGACCGCGGA
GTGTACCTGTCCCTCCTGGCCTCCCTCCGCACACGTGCCCAGTTGCCCGTGGTGGTGTTCACCTTCTCCCGGGGCCGCTGTGATGAGCAG
GCCTCAGGCCTCACCTCCCTTGACCTCACCACCAGTTCGGAGAAGAGCGAGATCCACCTCTTCCTGCAGCGCTGCCTTGCTCGCCTCCGT
GGCTCTGACCGCCAGCTGCCCCAGGTCCTGCACATGTCAGAGCTCCTGAATCGCGGCCTGGGTGTGCACCATAGCGGCATCCTGCCCATC
CTCAAGGAGATCGTGGAGATGCTCTTCAGCCGTGGCCTGGTCAAGGTCTTGTTTGCCACAGAGACCTTTGCCATGGGAGTAAACATGCCT
GCTCGTACAGTAGTGTTTGACTCCATGCGCAAACACGATGGCTCCACCTTCCGGGACCTGCTCCCTGGGGAGTATGTGCAGATGGCAGGC
CGGGCAGGGCGGAGGGGCCTGGACCCCACAGGCACCGTTATCCTGCTCTGCAAGGGCCGAGTGCCCGAGATGGCAGACCTGCACCGCATG
ATGATGTCTCTGAGTTTCCCTCCCGCAAAGACAGCAAGGGAGCTCTCCAAGGAGCAGGAGCTGGGTGATTTTGAGGAGGATTTTGATCCC
TCAGTGAAGTGGAAGCTCCTCCCCCAGGAAGAGCCTTAAAACCCCAAATTCTGTGTTCCTGTTTAAACCCGTGGTTTTTTTTAAATACAT
TTATTTTTATAGCAGCAATGTTCTATTTTTAGAAACTATATTATAAGTACAGAAATGGTTCTCCGTGTGGTGGGAGGAGGAGGTTCGGGT
GCTGGGTAAGTGCCATGTCAGTGTGGACAGAGGCATTTGACTAAGCCAACCTCCTCTCACAGCCTCTGTATCTCTGCAGGCCATACTGGT
TCCATTGTTCTGTATAATACTGAATAAATAAATTTACTTTTACATGATCGTATAAGTTTCTAGATAAGATAAACAAATTTTGTTTAAATT
TTTTTAATAAAAATCTTAAAACACTTTTTTTCTAACCTAGACTGAGAAATTCATGTTTACTTTTCTAGGTGTATGATACTTTGTAAAGTT
GATACTTTCCTAAGAATTTAACATGTCATATTTTTGAAATAGATTTAAGTGTGCTTCTTATTGCTAAAAATACTAAATGTCATGGGTCAT
AGTATCTGATATCAATATCGTTGATAACATATCCACAGGTAACACCATGATGTAGGCATAAATGGAAAACAAAAACCCTACTATTTCAAA
TATATTGTACTTTTTTATTTCTGTAAGCCAACTGTGTGCCATTTTCACTGGACTTTTAAATCTAGACTTTAGTGATGTCTACATTGTAAA
TGATCTTTTGTGGATATTTGTCACTTGGTTTCAGAAAGTTCACAAATGTAGCAACAGCTCACATGACTGAGTAGGTAGAAAATGTGAAAT

>82142_82142_2_SKIV2L-ABCA8_SKIV2L_chr6_31934591_ENST00000544581_ABCA8_chr17_66864316_ENST00000269080_length(amino acids)=581AA_BP=552
MDFAPKDCPTPAPGLLSLSCMLEPLDLGGGDEDENEAVGQPGGPRGDTVSASPCSAPLARASSLEDLVLKEASTAVSTPEAPEPPSQEQW
AIPVDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDF
RNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDVERGVVWEEVLIMLPDHVSIILLSATVPNALEF
ADWIGRLKRRQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGV
YLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPIL
KEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SKIV2L-ABCA8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SKIV2L-ABCA8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SKIV2L-ABCA8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSKIV2LC1857276Trichohepatoenteric Syndrome3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneSKIV2LC3281289TRICHOHEPATOENTERIC SYNDROME 23GENOMICS_ENGLAND;UNIPROT
HgeneSKIV2LC0021053Immune System Diseases1GENOMICS_ENGLAND
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human