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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD33B-NIPBL (FusionGDB2 ID:HG651746TG25836)

Fusion Gene Summary for ANKRD33B-NIPBL

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD33B-NIPBL
Fusion gene ID: hg651746tg25836
HgeneTgene
Gene symbol

ANKRD33B

NIPBL

Gene ID

651746

25836

Gene nameankyrin repeat domain 33BNIPBL cohesin loading factor
Synonyms-CDLS|CDLS1|IDN3|IDN3-B|Scc2
Cytomap('ANKRD33B')('NIPBL')

5p15.2

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 33BAnkyrin repeat domain-containing protein LOC651746nipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homolog
Modification date2020031320200313
UniProtAcc

A6NCL7

.
Ensembl transtripts involved in fusion geneENST00000296657, 
Fusion gene scores* DoF score9 X 3 X 6=1628 X 11 X 5=440
# samples 129
** MAII scorelog2(12/162*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/440*10)=-2.28950661719499
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD33B [Title/Abstract] AND NIPBL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD33B(10564945)-NIPBL(37058993), # samples:3
Anticipated loss of major functional domain due to fusion event.ANKRD33B-NIPBL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNIPBL

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

TgeneNIPBL

GO:0031065

positive regulation of histone deacetylation

18854353

TgeneNIPBL

GO:0045892

negative regulation of transcription, DNA-templated

18854353

TgeneNIPBL

GO:0071921

cohesin loading

22628566


check buttonFusion gene breakpoints across ANKRD33B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NIPBL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-B9-A5W9-01AANKRD33Bchr5

10564945

-NIPBLchr5

37058993

+
ChimerDB4KIRPTCGA-B9-A5W9-01AANKRD33Bchr5

10564945

+NIPBLchr5

37058993

+
ChimerDB4KIRPTCGA-B9-A5W9ANKRD33Bchr5

10564945

+NIPBLchr5

37058992

+
ChimerDB4KIRPTCGA-B9-A5W9ANKRD33Bchr5

10564945

+NIPBLchr5

37058993

+
ChimerDB4KIRPTCGA-B9-A5W9ANKRD33Bchr5

10564945

+NIPBLchr5

37063891

+
ChimerDB4KIRPTCGA-B9-A5W9ANKRD33Bchr5

10564945

+NIPBLchr5

37063892

+


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Fusion Gene ORF analysis for ANKRD33B-NIPBL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296657ENST00000504430ANKRD33Bchr5

10564945

+NIPBLchr5

37058993

+
5CDS-intronENST00000296657ENST00000504430ANKRD33Bchr5

10564945

+NIPBLchr5

37058992

+
5CDS-intronENST00000296657ENST00000504430ANKRD33Bchr5

10564945

+NIPBLchr5

37063891

+
5CDS-intronENST00000296657ENST00000504430ANKRD33Bchr5

10564945

+NIPBLchr5

37063892

+
Frame-shiftENST00000296657ENST00000448238ANKRD33Bchr5

10564945

+NIPBLchr5

37063891

+
Frame-shiftENST00000296657ENST00000448238ANKRD33Bchr5

10564945

+NIPBLchr5

37063892

+
In-frameENST00000296657ENST00000282516ANKRD33Bchr5

10564945

+NIPBLchr5

37058993

+
In-frameENST00000296657ENST00000282516ANKRD33Bchr5

10564945

+NIPBLchr5

37058992

+
In-frameENST00000296657ENST00000282516ANKRD33Bchr5

10564945

+NIPBLchr5

37063891

+
In-frameENST00000296657ENST00000282516ANKRD33Bchr5

10564945

+NIPBLchr5

37063892

+
In-frameENST00000296657ENST00000448238ANKRD33Bchr5

10564945

+NIPBLchr5

37058993

+
In-frameENST00000296657ENST00000448238ANKRD33Bchr5

10564945

+NIPBLchr5

37058992

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000296657ANKRD33Bchr510564945+ENST00000282516NIPBLchr537058993+289236601370456
ENST00000296657ANKRD33Bchr510564945+ENST00000448238NIPBLchr537058993+121736601049349
ENST00000296657ANKRD33Bchr510564945+ENST00000282516NIPBLchr537058992+289236601370456
ENST00000296657ANKRD33Bchr510564945+ENST00000448238NIPBLchr537058992+121736601049349
ENST00000296657ANKRD33Bchr510564945+ENST00000282516NIPBLchr537063891+24423660920306
ENST00000296657ANKRD33Bchr510564945+ENST00000282516NIPBLchr537063892+24423660920306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296657ENST00000282516ANKRD33Bchr510564945+NIPBLchr537058993+0.0007480650.9992519
ENST00000296657ENST00000448238ANKRD33Bchr510564945+NIPBLchr537058993+0.0038801760.99611986
ENST00000296657ENST00000282516ANKRD33Bchr510564945+NIPBLchr537058992+0.0007480650.9992519
ENST00000296657ENST00000448238ANKRD33Bchr510564945+NIPBLchr537058992+0.0038801760.99611986
ENST00000296657ENST00000282516ANKRD33Bchr510564945+NIPBLchr537063891+0.000616580.99938345
ENST00000296657ENST00000282516ANKRD33Bchr510564945+NIPBLchr537063892+0.000616580.99938345

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Fusion Genomic Features for ANKRD33B-NIPBL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD33Bchr510564945+NIPBLchr537058992+3.16E-050.9999684
ANKRD33Bchr510564945+NIPBLchr537058992+3.16E-050.9999684
ANKRD33Bchr510564945+NIPBLchr537063891+4.00E-060.99999595
ANKRD33Bchr510564945+NIPBLchr537058992+3.16E-050.9999684
ANKRD33Bchr510564945+NIPBLchr537058992+3.16E-050.9999684
ANKRD33Bchr510564945+NIPBLchr537063891+4.00E-060.99999595

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANKRD33B-NIPBL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:10564945/chr5:37058993)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD33B

A6NCL7

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+1419_25122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+1419_25122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+1419_25122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+1419_25122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+1484_113122495.0RepeatNote=ANK 1
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+1484_113122495.0RepeatNote=ANK 1
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+1484_113122495.0RepeatNote=ANK 1
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+1484_113122495.0RepeatNote=ANK 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14459_488122495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14459_488122495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14459_488122495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14459_488122495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14264_267122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14264_267122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14264_267122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14264_267122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14120_150122495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14154_183122495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14189_218122495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14223_255122495.0RepeatNote=ANK 5
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14120_150122495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14154_183122495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14189_218122495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14223_255122495.0RepeatNote=ANK 5
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14120_150122495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14154_183122495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14189_218122495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14223_255122495.0RepeatNote=ANK 5
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14120_150122495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14154_183122495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14189_218122495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14223_255122495.0RepeatNote=ANK 5
TgeneNIPBLchr5:10564945chr5:37058992ENST000002825164247418_46224702805.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37058992ENST000004482384246418_46224702698.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37058993ENST000002825164247418_46224702805.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37058993ENST000004482384246418_46224702698.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37063891ENST000002825164447418_46226202805.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37063891ENST000004482384446418_46226202698.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37063892ENST000002825164447418_46226202805.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37063892ENST000004482384446418_46226202698.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37058992ENST000002825164247996_100924702805.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37058992ENST000004482384246996_100924702698.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37058993ENST000002825164247996_100924702805.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37058993ENST000004482384246996_100924702698.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37063891ENST000002825164447996_100926202805.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37063891ENST000004482384446996_100926202698.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37063892ENST000002825164447996_100926202805.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37063892ENST000004482384446996_100926202698.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642471767_180524702805.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642471843_188124702805.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642471945_198424702805.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642472227_226724702805.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642472313_235124702805.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842461767_180524702698.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842461843_188124702698.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842461945_198424702698.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842462227_226724702698.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842462313_235124702698.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642471767_180524702805.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642471843_188124702805.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642471945_198424702805.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642472227_226724702805.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642472313_235124702805.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842461767_180524702698.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842461843_188124702698.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842461945_198424702698.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842462227_226724702698.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842462313_235124702698.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644471767_180526202805.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644471843_188126202805.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644471945_198426202805.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644472227_226726202805.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644472313_235126202805.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844461767_180526202698.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844461843_188126202698.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844461945_198426202698.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844462227_226726202698.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844462313_235126202698.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644471767_180526202805.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644471843_188126202805.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644471945_198426202805.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644472227_226726202805.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644472313_235126202805.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844461767_180526202698.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844461843_188126202698.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844461945_198426202698.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844462227_226726202698.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844462313_235126202698.0RepeatNote=HEAT 5


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Fusion Gene Sequence for ANKRD33B-NIPBL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4704_4704_1_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058992_ENST00000282516_length(transcript)=2892nt_BP=366nt
ATGGTGCTGCTGGCCGGGACCGGGCCGGAGGGCGGCGGGGCGCGCTGCATGACCCCACCACCGCCGTCCCCACCCCGGGGCGCGCAGGTC
GAGGAGGACCCCGCTGACTACGAAGAGTTTGAGGACTTCTCGAGTCTGCCAGACACCCGCAGCATCGCCTCGGACGACTCTTTCTACCCT
TTCGAGGACGAGGAGGAGCACGGCGTCGAGAGCGCGGAGAGCGTCCCGGAGGGCGTCCCGGAAAGCGTCCCGGAGACGGCGACCCTCCTG
CGCGCCGCCTGCGCCAACAACGTGGGGCTGCTGCGGACGCTGGTGCGGCGCGGGGTGAGCGTCGAGGAGGCGCAGGAGACTGACCGCAAC
GGCAGGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCC
AGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAA
AATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGA
TTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTT
CATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTAT
CTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAA
GCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGA
GGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATG
GATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAG
TGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAG
TCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCC
AAGGATGGGACTTCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACAT
TCTGGCAAAAAAAAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGG
GAGCTCCCTTCGCTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCT
TGGAAAAAAAACTTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTT
AACCTAGCAGCGGATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGA
TATATAATTTATTCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGT
ATTAGGTCACCCTGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTG
TTACTTGTCTGTTTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATT
ATATCACTGGTTTTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCAT
TCCCATAAGAGGGTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCA
AACACATTTTCAAGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGC
TGATATTTATTCTTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTA
GAACTAGAGTTGAGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTA
CTTGTTGAGATGTTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTG
CAGATATCTTGACTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGT
GGATGAGGTCTGTTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTT
TTATGAAATTGGCAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCA

>4704_4704_1_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058992_ENST00000282516_length(amino acids)=456AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRSMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPE
NSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQY
LDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVM
DVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAA

--------------------------------------------------------------
>4704_4704_2_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058992_ENST00000448238_length(transcript)=1217nt_BP=366nt
ATGGTGCTGCTGGCCGGGACCGGGCCGGAGGGCGGCGGGGCGCGCTGCATGACCCCACCACCGCCGTCCCCACCCCGGGGCGCGCAGGTC
GAGGAGGACCCCGCTGACTACGAAGAGTTTGAGGACTTCTCGAGTCTGCCAGACACCCGCAGCATCGCCTCGGACGACTCTTTCTACCCT
TTCGAGGACGAGGAGGAGCACGGCGTCGAGAGCGCGGAGAGCGTCCCGGAGGGCGTCCCGGAAAGCGTCCCGGAGACGGCGACCCTCCTG
CGCGCCGCCTGCGCCAACAACGTGGGGCTGCTGCGGACGCTGGTGCGGCGCGGGGTGAGCGTCGAGGAGGCGCAGGAGACTGACCGCAAC
GGCAGGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCC
AGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAA
AATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGA
TTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTT
CATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTAT
CTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAA
GCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGA
GGAGGCACTTCAGGGGTGAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGT
CTATTAAATGTACACCAAGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTT

>4704_4704_2_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058992_ENST00000448238_length(amino acids)=349AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRSMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPE
NSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQY

--------------------------------------------------------------
>4704_4704_3_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058993_ENST00000282516_length(transcript)=2892nt_BP=366nt
ATGGTGCTGCTGGCCGGGACCGGGCCGGAGGGCGGCGGGGCGCGCTGCATGACCCCACCACCGCCGTCCCCACCCCGGGGCGCGCAGGTC
GAGGAGGACCCCGCTGACTACGAAGAGTTTGAGGACTTCTCGAGTCTGCCAGACACCCGCAGCATCGCCTCGGACGACTCTTTCTACCCT
TTCGAGGACGAGGAGGAGCACGGCGTCGAGAGCGCGGAGAGCGTCCCGGAGGGCGTCCCGGAAAGCGTCCCGGAGACGGCGACCCTCCTG
CGCGCCGCCTGCGCCAACAACGTGGGGCTGCTGCGGACGCTGGTGCGGCGCGGGGTGAGCGTCGAGGAGGCGCAGGAGACTGACCGCAAC
GGCAGGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCC
AGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAA
AATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGA
TTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTT
CATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTAT
CTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAA
GCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGA
GGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATG
GATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAG
TGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAG
TCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCC
AAGGATGGGACTTCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACAT
TCTGGCAAAAAAAAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGG
GAGCTCCCTTCGCTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCT
TGGAAAAAAAACTTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTT
AACCTAGCAGCGGATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGA
TATATAATTTATTCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGT
ATTAGGTCACCCTGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTG
TTACTTGTCTGTTTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATT
ATATCACTGGTTTTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCAT
TCCCATAAGAGGGTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCA
AACACATTTTCAAGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGC
TGATATTTATTCTTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTA
GAACTAGAGTTGAGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTA
CTTGTTGAGATGTTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTG
CAGATATCTTGACTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGT
GGATGAGGTCTGTTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTT
TTATGAAATTGGCAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCA

>4704_4704_3_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058993_ENST00000282516_length(amino acids)=456AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRSMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPE
NSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQY
LDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVM
DVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAA

--------------------------------------------------------------
>4704_4704_4_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058993_ENST00000448238_length(transcript)=1217nt_BP=366nt
ATGGTGCTGCTGGCCGGGACCGGGCCGGAGGGCGGCGGGGCGCGCTGCATGACCCCACCACCGCCGTCCCCACCCCGGGGCGCGCAGGTC
GAGGAGGACCCCGCTGACTACGAAGAGTTTGAGGACTTCTCGAGTCTGCCAGACACCCGCAGCATCGCCTCGGACGACTCTTTCTACCCT
TTCGAGGACGAGGAGGAGCACGGCGTCGAGAGCGCGGAGAGCGTCCCGGAGGGCGTCCCGGAAAGCGTCCCGGAGACGGCGACCCTCCTG
CGCGCCGCCTGCGCCAACAACGTGGGGCTGCTGCGGACGCTGGTGCGGCGCGGGGTGAGCGTCGAGGAGGCGCAGGAGACTGACCGCAAC
GGCAGGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCC
AGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAA
AATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGA
TTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTT
CATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTAT
CTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAA
GCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGA
GGAGGCACTTCAGGGGTGAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGT
CTATTAAATGTACACCAAGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTT

>4704_4704_4_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058993_ENST00000448238_length(amino acids)=349AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRSMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPE
NSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQY

--------------------------------------------------------------
>4704_4704_5_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37063891_ENST00000282516_length(transcript)=2442nt_BP=366nt
ATGGTGCTGCTGGCCGGGACCGGGCCGGAGGGCGGCGGGGCGCGCTGCATGACCCCACCACCGCCGTCCCCACCCCGGGGCGCGCAGGTC
GAGGAGGACCCCGCTGACTACGAAGAGTTTGAGGACTTCTCGAGTCTGCCAGACACCCGCAGCATCGCCTCGGACGACTCTTTCTACCCT
TTCGAGGACGAGGAGGAGCACGGCGTCGAGAGCGCGGAGAGCGTCCCGGAGGGCGTCCCGGAAAGCGTCCCGGAGACGGCGACCCTCCTG
CGCGCCGCCTGCGCCAACAACGTGGGGCTGCTGCGGACGCTGGTGCGGCGCGGGGTGAGCGTCGAGGAGGCGCAGGAGACTGACCGCAAC
GGCAGGTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAA
GCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGA
GGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATG
GATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAG
TGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAG
TCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCC
AAGGATGGGACTTCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACAT
TCTGGCAAAAAAAAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGG
GAGCTCCCTTCGCTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCT
TGGAAAAAAAACTTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTT
AACCTAGCAGCGGATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGA
TATATAATTTATTCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGT
ATTAGGTCACCCTGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTG
TTACTTGTCTGTTTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATT
ATATCACTGGTTTTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCAT
TCCCATAAGAGGGTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCA
AACACATTTTCAAGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGC
TGATATTTATTCTTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTA
GAACTAGAGTTGAGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTA
CTTGTTGAGATGTTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTG
CAGATATCTTGACTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGT
GGATGAGGTCTGTTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTT
TTATGAAATTGGCAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCA

>4704_4704_5_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37063891_ENST00000282516_length(amino acids)=306AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRG
GGTSGSLRRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKE

--------------------------------------------------------------
>4704_4704_6_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37063892_ENST00000282516_length(transcript)=2442nt_BP=366nt
ATGGTGCTGCTGGCCGGGACCGGGCCGGAGGGCGGCGGGGCGCGCTGCATGACCCCACCACCGCCGTCCCCACCCCGGGGCGCGCAGGTC
GAGGAGGACCCCGCTGACTACGAAGAGTTTGAGGACTTCTCGAGTCTGCCAGACACCCGCAGCATCGCCTCGGACGACTCTTTCTACCCT
TTCGAGGACGAGGAGGAGCACGGCGTCGAGAGCGCGGAGAGCGTCCCGGAGGGCGTCCCGGAAAGCGTCCCGGAGACGGCGACCCTCCTG
CGCGCCGCCTGCGCCAACAACGTGGGGCTGCTGCGGACGCTGGTGCGGCGCGGGGTGAGCGTCGAGGAGGCGCAGGAGACTGACCGCAAC
GGCAGGTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAA
GCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGA
GGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATG
GATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAG
TGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAG
TCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCC
AAGGATGGGACTTCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACAT
TCTGGCAAAAAAAAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGG
GAGCTCCCTTCGCTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCT
TGGAAAAAAAACTTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTT
AACCTAGCAGCGGATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGA
TATATAATTTATTCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGT
ATTAGGTCACCCTGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTG
TTACTTGTCTGTTTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATT
ATATCACTGGTTTTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCAT
TCCCATAAGAGGGTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCA
AACACATTTTCAAGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGC
TGATATTTATTCTTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTA
GAACTAGAGTTGAGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTA
CTTGTTGAGATGTTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTG
CAGATATCTTGACTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGT
GGATGAGGTCTGTTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTT
TTATGAAATTGGCAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCA

>4704_4704_6_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37063892_ENST00000282516_length(amino acids)=306AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRG
GGTSGSLRRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKRD33B-NIPBL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD33B-NIPBL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD33B-NIPBL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4551851Cornelia de Lange Syndrome 116CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0270972Cornelia De Lange Syndrome8CLINGEN;CTD_human
TgeneC1802395Congenital muscular hypertrophy-cerebral syndrome3CTD_human
TgeneC1853099Cornelia de Lange Syndrome 33CTD_human
TgeneC0005941Bone Diseases, Developmental1CTD_human
TgeneC0018798Congenital Heart Defects1CTD_human
TgeneC0155536Paracousis1CTD_human
TgeneC0260662Hearing problem1CTD_human
TgeneC0376634Craniofacial Abnormalities1CTD_human
TgeneC0877848Distorted hearing1CTD_human
TgeneC1510450Dysacusis1CTD_human
TgeneC2750805Chromosome 5p13 Duplication Syndrome1ORPHANET