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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BMPR2-MARCH4 (FusionGDB2 ID:HG659TG57574)

Fusion Gene Summary for BMPR2-MARCH4

check button Fusion gene summary
Fusion gene informationFusion gene name: BMPR2-MARCH4
Fusion gene ID: hg659tg57574
HgeneTgene
Gene symbol

BMPR2

MARCH4

Gene ID

659

57574

Gene namebone morphogenetic protein receptor type 2membrane associated ring-CH-type finger 4
SynonymsBMPR-II|BMPR3|BMR2|BRK-3|POVD1|PPH1|T-ALKMARCH-IV|MARCH4|RNF174
Cytomap('BMPR2')('MARCH4')

2q33.1-q33.2

2q35

Type of geneprotein-codingprotein-coding
Descriptionbone morphogenetic protein receptor type-2BMP type II receptorBMP type-2 receptorbone morphogenetic protein receptor type IIbone morphogenetic protein receptor, type II (serine/threonine kinase)type II activin receptor-like kinasetype II receptor foE3 ubiquitin-protein ligase MARCH4RING finger protein 174RING-type E3 ubiquitin transferase MARCH4membrane associated ring finger 4membrane-associated RING finger protein 4membrane-associated RING-CH protein IVmembrane-associated ring finger (C3HC4)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000374574, ENST00000374580, 
ENST00000479069, 
Fusion gene scores* DoF score20 X 12 X 9=21604 X 3 X 4=48
# samples 214
** MAII scorelog2(21/2160*10)=-3.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BMPR2 [Title/Abstract] AND MARCH4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBMPR2(203407170)-MARCH4(217124402), # samples:4
Anticipated loss of major functional domain due to fusion event.BMPR2-MARCH4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BMPR2-MARCH4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBMPR2

GO:0007178

transmembrane receptor protein serine/threonine kinase signaling pathway

12045205

HgeneBMPR2

GO:0010634

positive regulation of epithelial cell migration

12819188

HgeneBMPR2

GO:0030308

negative regulation of cell growth

12819188

HgeneBMPR2

GO:0030509

BMP signaling pathway

18436533


check buttonFusion gene breakpoints across BMPR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MARCH4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8258-01ABMPR2chr2

203407170

-MARCH4chr2

217124402

-
ChimerDB4PRADTCGA-HC-8258-01ABMPR2chr2

203407170

+MARCH4chr2

217124402

-
ChimerDB4PRADTCGA-HC-8258BMPR2chr2

203407170

+MARCH4chr2

217124402

-


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Fusion Gene ORF analysis for BMPR2-MARCH4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000374574ENST00000273067BMPR2chr2

203407170

+MARCH4chr2

217124402

-
In-frameENST00000374580ENST00000273067BMPR2chr2

203407170

+MARCH4chr2

217124402

-
intron-3CDSENST00000479069ENST00000273067BMPR2chr2

203407170

+MARCH4chr2

217124402

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000374580BMPR2chr2203407170+ENST00000273067MARCH4chr2217124402-376719525242032502
ENST00000374574BMPR2chr2203407170+ENST00000273067MARCH4chr2217124402-32691454261534502

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374580ENST00000273067BMPR2chr2203407170+MARCH4chr2217124402-0.0042614020.9957386
ENST00000374574ENST00000273067BMPR2chr2203407170+MARCH4chr2217124402-0.0036413340.9963587

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Fusion Genomic Features for BMPR2-MARCH4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BMPR2-MARCH4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:203407170/chr2:217124402)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+1013209_2174711039.0Nucleotide bindingATP
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+1013280_2824711039.0Nucleotide bindingATP
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+1013337_3384711039.0Nucleotide bindingATP
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+101327_1504711039.0Topological domainExtracellular
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+1013151_1714711039.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+1013547_5504711039.0Compositional biasNote=Poly-Ser
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+1013610_6184711039.0Compositional biasNote=Poly-Thr
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+1013901_9084711039.0Compositional biasNote=Poly-Asn
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+1013203_5044711039.0DomainProtein kinase
HgeneBMPR2chr2:203407170chr2:217124402ENST00000374580+1013172_10384711039.0Topological domainCytoplasmic
TgeneMARCH4chr2:203407170chr2:217124402ENST000002730672457_127288411.0Compositional biasNote=Pro-rich
TgeneMARCH4chr2:203407170chr2:217124402ENST0000027306724238_258288411.0TransmembraneHelical
TgeneMARCH4chr2:203407170chr2:217124402ENST0000027306724272_292288411.0TransmembraneHelical
TgeneMARCH4chr2:203407170chr2:217124402ENST0000027306724155_215288411.0Zinc fingerRING-CH-type


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Fusion Gene Sequence for BMPR2-MARCH4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9934_9934_1_BMPR2-MARCH4_BMPR2_chr2_203407170_ENST00000374574_MARCH4_chr2_217124402_ENST00000273067_length(transcript)=3269nt_BP=1454nt
ATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGA
CCATCCTGCTGGTCAGCACTGCGGCTGCTTCGCAGAATCAAGAACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAG
GTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGCTCGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACA
TAAATCTTGTAAAACAAGGATGTTGGTCTCACATTGGAGATCCCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCT
CAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACAGATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAA
CACCACTCAGTCCACCTCATTCATTTAACCGAGATGAGACAATAATCATTGCTTTGGCATCAGTCTCTGTATTAGCTGTTTTGATAGTTG
CCTTATGCTTTGGATACAGAATGTTGACAGGAGACCGTAAACAAGGTCTTCACAGTATGAACATGATGGAGGCAGCAGCATCCGAACCCT
CTCTTGATCTAGATAATCTGAAACTGTTGGAGCTGATTGGCCGAGGTCGATATGGAGCAGTATATAAAGGCTCCTTGGATGAGCGTCCAG
TTGCTGTAAAAGTGTTTTCCTTTGCAAACCGTCAGAATTTTATCAACGAAAAGAACATTTACAGAGTGCCTTTGATGGAACATGACAACA
TTGCCCGCTTTATAGTTGGAGATGAGAGAGTCACTGCAGATGGACGCATGGAATATTTGCTTGTGATGGAGTACTATCCCAATGGATCTT
TATGCAAGTATTTAAGTCTCCACACAAGTGACTGGGTAAGCTCTTGCCGTCTTGCTCATTCTGTTACTAGAGGACTGGCTTATCTTCACA
CAGAATTACCACGAGGAGATCATTATAAACCTGCAATTTCCCATCGAGATTTAAACAGCAGAAATGTCCTAGTGAAAAATGATGGAACCT
GTGTTATTAGTGACTTTGGACTGTCCATGAGGCTGACTGGAAATAGACTGGTGCGCCCAGGGGAGGAAGATAATGCAGCCATAAGCGAGG
TTGGCACTATCAGATATATGGCACCAGAAGTGCTAGAAGGAGCTGTGAACTTGAGGGACTGTGAATCAGCTTTGAAACAAGTAGACATGT
ATGCTCTTGGACTAATCTATTGGGAGATATTTATGAGATGTACAGACCTCTTCCCAGGGGAATCCGTACCAGAGTACCAGATGGCTTTTC
AGACAGAGGTTGGAAACCATCCCACTTTTGAGGATATGCAGGTTCTCGTGTCTAGGGAAAAACAGAGACCCAAGTTCCCAGAAGCCTGGA
AAGAAAATAGCCTGGTCTCATCATCCATGAAGGACCCTCGGTGTACCGCATCTTTAAACGGTGGCAGGCTGTCAACCAGCAGTGGAAAGT
GCTGAACTATGACAAGACAAAAGACCTGGAGGATCAAAAGGCAGGAGGCAGGACCAACCCCCGGACCTCCTCATCCACCCAGGCCAATAT
CCCCTCCTCGGAAGAGGAGACCGCAGGCACCCCTGCCCCTGAGCAGGGCCCTGCCCAGGCTGCCGGCCACCCCTCAGGCCCTCTGTCCCA
TCACCACTGTGCTTATACCATCCTGCACATCCTGAGTCACTTGAGACCTCATGAACAGCGAAGTCCCCCAGGCAGCAGCCGAGAGCTGGT
CATGAGAGTCACGACAGTGTGAGAGCAGAGGCCCGGAAGGAAGGCCATGACCACCACTGAGGGCCCGGAGCAGGGTGGGGAGGTGCAGTG
GCACCCCCAGAGCCAACAGAGGGAGCAGGCAGAGGGTGGGGGACCTGGCGGGAGCCCTGGGGTAGTGTCAGAGCGGGAGTGAGGCTGGTG
CAGGAGCAGTTCTGCTATTTCCAATCAGTCAATGCCACTCTCCACAACAACAATGAAAACCAACACCAACTCAACAACAAAGTGCAATAC
AGGCTGAACCTGGCCCAACAGAAAAACCCTGCCCCAATGCACCTGCAGGCAAGGTACCCGAAGAAGCAGAGGCTGAGGGCAGGCAAAGCC
TGTGTGACTGTGGCAGTGCCGGAGGCCAAGGGGGCCAAGAGGAAAAGCATCTGTGGTCTGCTCTGCTCTCACCCTGTTTGGTTTTGTTTC
TCCTGGGGCTGTGTTCTGCAGGCAGCCAGAAAAGGAGGAGGCACGGGTGAGCTGGCAGGGACACACTGCCTTTGGGGCTCCTGGGCTCAT
TTGGATGGGCAAGATTCGCTGACAAATGGCTGTGGGGATGGTGGGGTGGATGGTCAGGGAGGGATGCTCAGGGAGGGATATGCTGGTGTG
AGCAGCCAGAGGGAGAGTGTGTCTCCTTCCTGAAGGAACTTCCAAATGGAACTCCCGATTTCAGGTGGGCTAAAAGAGGGCTTAGGTTTG
GAAAAGGGTGTCCTTCTGTGCCCTTGTTAATTTATTTTATAGTGATTTGGTTCAAAGATGTTTACAGGACACACACACACACACACACAC
ACACACACACACACACCCCTAGAGAAAAGTACAGATTTCCAGTGGATATTTCAAGCACAGTTCTGCTGCTGTGGCTTCAGCTTTGGAAGC
TGTCAATCCCGGAGCAACTTTCCCAACTACCCAACCCCACCATGGCCAGGACATGTGCAATGCCAGCCCCTTCTTGTCTTGGCACATGCA
CAGACCCAGTCCCCTCACGGTAGGGCACCCCTGACCTACGGGCTTCCAAGAGAGCAGCTGCAGTGGTTGGGAGGAGCTTGACCAGTGTGC
CCCAAGGAGTGGAGTAGAGCCCAATCTAAGTATTCCTTGCTGCTTGGAACCCTCCCTGTTTGGAACCCTCCCCAAAGAGGCAGTCAGGCT
GATGCTCAGTGCTTTGTGCTCCCTGCTCCTTCCCGCGTAGCCAGGTGGGCCCAAGGGTGCCTGGCAGGGAGCACTACCCCTGGACCCCTC
CTGCTCGCTCTGGGGACCCTGCCAGGGAAGGCCACTGGGTGTTCACCTGCAAAGTTTCTGGTTGTCACTGCACAGTGGTCGCGTCATCCA
TGGGTATTAAAAGGACACTGTCAAGTACTTTTTTAAACTAGTTTTTAGGGTTTTTTAAAACTCTCTGTTGTTTGTAATATTCTCTTAAAA

>9934_9934_1_BMPR2-MARCH4_BMPR2_chr2_203407170_ENST00000374574_MARCH4_chr2_217124402_ENST00000273067_length(amino acids)=502AA_BP=476
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCW
SHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRML
TGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDE
RVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLS
MRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPT

--------------------------------------------------------------
>9934_9934_2_BMPR2-MARCH4_BMPR2_chr2_203407170_ENST00000374580_MARCH4_chr2_217124402_ENST00000273067_length(transcript)=3767nt_BP=1952nt
GGAAGCACCGAAGCGAAACTTAAGGAATCCTGCCTTCCCGGAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCC
GGCTTCGTCCTTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGAATCCCCGCCCTCCGCACCCTGGATATGT
TTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAACTACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCAC
AGACATGCCTTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGGAGAGAAATGAAGGGAATTTCT
GCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCAGCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGG
GAGAGAAGACGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGA
TGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGCTTCGCAGAATCAAG
AACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAGGTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGCT
CGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACATAAATCTTGTAAAACAAGGATGTTGGTCTCACATTGGAGATC
CCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCTCAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACAG
ATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAACACCACTCAGTCCACCTCATTCATTTAACCGAGATGAGACAA
TAATCATTGCTTTGGCATCAGTCTCTGTATTAGCTGTTTTGATAGTTGCCTTATGCTTTGGATACAGAATGTTGACAGGAGACCGTAAAC
AAGGTCTTCACAGTATGAACATGATGGAGGCAGCAGCATCCGAACCCTCTCTTGATCTAGATAATCTGAAACTGTTGGAGCTGATTGGCC
GAGGTCGATATGGAGCAGTATATAAAGGCTCCTTGGATGAGCGTCCAGTTGCTGTAAAAGTGTTTTCCTTTGCAAACCGTCAGAATTTTA
TCAACGAAAAGAACATTTACAGAGTGCCTTTGATGGAACATGACAACATTGCCCGCTTTATAGTTGGAGATGAGAGAGTCACTGCAGATG
GACGCATGGAATATTTGCTTGTGATGGAGTACTATCCCAATGGATCTTTATGCAAGTATTTAAGTCTCCACACAAGTGACTGGGTAAGCT
CTTGCCGTCTTGCTCATTCTGTTACTAGAGGACTGGCTTATCTTCACACAGAATTACCACGAGGAGATCATTATAAACCTGCAATTTCCC
ATCGAGATTTAAACAGCAGAAATGTCCTAGTGAAAAATGATGGAACCTGTGTTATTAGTGACTTTGGACTGTCCATGAGGCTGACTGGAA
ATAGACTGGTGCGCCCAGGGGAGGAAGATAATGCAGCCATAAGCGAGGTTGGCACTATCAGATATATGGCACCAGAAGTGCTAGAAGGAG
CTGTGAACTTGAGGGACTGTGAATCAGCTTTGAAACAAGTAGACATGTATGCTCTTGGACTAATCTATTGGGAGATATTTATGAGATGTA
CAGACCTCTTCCCAGGGGAATCCGTACCAGAGTACCAGATGGCTTTTCAGACAGAGGTTGGAAACCATCCCACTTTTGAGGATATGCAGG
TTCTCGTGTCTAGGGAAAAACAGAGACCCAAGTTCCCAGAAGCCTGGAAAGAAAATAGCCTGGTCTCATCATCCATGAAGGACCCTCGGT
GTACCGCATCTTTAAACGGTGGCAGGCTGTCAACCAGCAGTGGAAAGTGCTGAACTATGACAAGACAAAAGACCTGGAGGATCAAAAGGC
AGGAGGCAGGACCAACCCCCGGACCTCCTCATCCACCCAGGCCAATATCCCCTCCTCGGAAGAGGAGACCGCAGGCACCCCTGCCCCTGA
GCAGGGCCCTGCCCAGGCTGCCGGCCACCCCTCAGGCCCTCTGTCCCATCACCACTGTGCTTATACCATCCTGCACATCCTGAGTCACTT
GAGACCTCATGAACAGCGAAGTCCCCCAGGCAGCAGCCGAGAGCTGGTCATGAGAGTCACGACAGTGTGAGAGCAGAGGCCCGGAAGGAA
GGCCATGACCACCACTGAGGGCCCGGAGCAGGGTGGGGAGGTGCAGTGGCACCCCCAGAGCCAACAGAGGGAGCAGGCAGAGGGTGGGGG
ACCTGGCGGGAGCCCTGGGGTAGTGTCAGAGCGGGAGTGAGGCTGGTGCAGGAGCAGTTCTGCTATTTCCAATCAGTCAATGCCACTCTC
CACAACAACAATGAAAACCAACACCAACTCAACAACAAAGTGCAATACAGGCTGAACCTGGCCCAACAGAAAAACCCTGCCCCAATGCAC
CTGCAGGCAAGGTACCCGAAGAAGCAGAGGCTGAGGGCAGGCAAAGCCTGTGTGACTGTGGCAGTGCCGGAGGCCAAGGGGGCCAAGAGG
AAAAGCATCTGTGGTCTGCTCTGCTCTCACCCTGTTTGGTTTTGTTTCTCCTGGGGCTGTGTTCTGCAGGCAGCCAGAAAAGGAGGAGGC
ACGGGTGAGCTGGCAGGGACACACTGCCTTTGGGGCTCCTGGGCTCATTTGGATGGGCAAGATTCGCTGACAAATGGCTGTGGGGATGGT
GGGGTGGATGGTCAGGGAGGGATGCTCAGGGAGGGATATGCTGGTGTGAGCAGCCAGAGGGAGAGTGTGTCTCCTTCCTGAAGGAACTTC
CAAATGGAACTCCCGATTTCAGGTGGGCTAAAAGAGGGCTTAGGTTTGGAAAAGGGTGTCCTTCTGTGCCCTTGTTAATTTATTTTATAG
TGATTTGGTTCAAAGATGTTTACAGGACACACACACACACACACACACACACACACACACACACCCCTAGAGAAAAGTACAGATTTCCAG
TGGATATTTCAAGCACAGTTCTGCTGCTGTGGCTTCAGCTTTGGAAGCTGTCAATCCCGGAGCAACTTTCCCAACTACCCAACCCCACCA
TGGCCAGGACATGTGCAATGCCAGCCCCTTCTTGTCTTGGCACATGCACAGACCCAGTCCCCTCACGGTAGGGCACCCCTGACCTACGGG
CTTCCAAGAGAGCAGCTGCAGTGGTTGGGAGGAGCTTGACCAGTGTGCCCCAAGGAGTGGAGTAGAGCCCAATCTAAGTATTCCTTGCTG
CTTGGAACCCTCCCTGTTTGGAACCCTCCCCAAAGAGGCAGTCAGGCTGATGCTCAGTGCTTTGTGCTCCCTGCTCCTTCCCGCGTAGCC
AGGTGGGCCCAAGGGTGCCTGGCAGGGAGCACTACCCCTGGACCCCTCCTGCTCGCTCTGGGGACCCTGCCAGGGAAGGCCACTGGGTGT
TCACCTGCAAAGTTTCTGGTTGTCACTGCACAGTGGTCGCGTCATCCATGGGTATTAAAAGGACACTGTCAAGTACTTTTTTAAACTAGT

>9934_9934_2_BMPR2-MARCH4_BMPR2_chr2_203407170_ENST00000374580_MARCH4_chr2_217124402_ENST00000273067_length(amino acids)=502AA_BP=476
MAGPGMTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCW
SHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRML
TGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDE
RVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLS
MRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPT

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Fusion Gene PPI Analysis for BMPR2-MARCH4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BMPR2-MARCH4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BMPR2-MARCH4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBMPR2C4552070Pulmonary Hypertension, Primary, 112CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneBMPR2C0020542Pulmonary Hypertension9CTD_human
HgeneBMPR2C0340543Familial primary pulmonary hypertension4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneBMPR2C0034091Pulmonary Veno-Occlusive Disease (disorder)3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneBMPR2C1701939Familial pulmonary arterial hypertension2ORPHANET
HgeneBMPR2C3203102Idiopathic pulmonary arterial hypertension2CTD_human;GENOMICS_ENGLAND
HgeneBMPR2C0006142Malignant neoplasm of breast1CTD_human
HgeneBMPR2C0152171Idiopathic pulmonary hypertension1GENOMICS_ENGLAND
HgeneBMPR2C0206081Hyperandrogenism1CTD_human
HgeneBMPR2C0340544Pulmonary arterial hypertension induced by drug1ORPHANET
HgeneBMPR2C0678222Breast Carcinoma1CTD_human
HgeneBMPR2C11509292-oxo-hept-3-ene-1,7-dioate hydratase activity1GENOMICS_ENGLAND
HgeneBMPR2C1257931Mammary Neoplasms, Human1CTD_human
HgeneBMPR2C1458155Mammary Neoplasms1CTD_human
HgeneBMPR2C1969342PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED1CTD_human
HgeneBMPR2C1969343Pulmonary Hypertension, Primary, Fenfluramine-Associated1CTD_human
HgeneBMPR2C2973725Pulmonary arterial hypertension1GENOMICS_ENGLAND
HgeneBMPR2C3714844Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia1CTD_human
HgeneBMPR2C3887658PULMONARY VENOOCCLUSIVE DISEASE 1, AUTOSOMAL DOMINANT1GENOMICS_ENGLAND
HgeneBMPR2C4704874Mammary Carcinoma, Human1CTD_human