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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:BNIP3-PPP2R2D (FusionGDB2 ID:HG664TG55844) |
Fusion Gene Summary for BNIP3-PPP2R2D |
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Fusion gene information | Fusion gene name: BNIP3-PPP2R2D | Fusion gene ID: hg664tg55844 | Hgene | Tgene | Gene symbol | BNIP3 | PPP2R2D | Gene ID | 664 | 55844 |
Gene name | BCL2 interacting protein 3 | protein phosphatase 2 regulatory subunit Bdelta | |
Synonyms | NIP3 | B55D|B55delta|MDS026 | |
Cytomap | ('BNIP3')('PPP2R2D') 10q26.3 | 10q26.3 | |
Type of gene | protein-coding | protein-coding | |
Description | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3BCL2/adenovirus E1B 19kDa interacting protein 3BCL2/adenovirus E1B interacting protein 3nineteen kD interacting protein-3 | serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformPP2A subunit B isoform B55-deltaPP2A subunit B isoform PR55-deltaPP2A subunit B isoform R2-deltaPP2A subunit B isoform deltaprotein phosphatase 2 regulatory subunit B, d | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000368636, ENST00000540159, | ENST00000368636, ENST00000540159, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 7 X 3=126 |
# samples | 3 | 7 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BNIP3 [Title/Abstract] AND PPP2R2D [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | BNIP3(133795265)-PPP2R2D(133769188), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | BNIP3-PPP2R2D seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BNIP3 | GO:0008626 | granzyme-mediated apoptotic signaling pathway | 9396766 |
Hgene | BNIP3 | GO:0010637 | negative regulation of mitochondrial fusion | 20436456 |
Hgene | BNIP3 | GO:0043065 | positive regulation of apoptotic process | 9973195|10381623 |
Hgene | BNIP3 | GO:0043068 | positive regulation of programmed cell death | 10891486 |
Hgene | BNIP3 | GO:0043243 | positive regulation of protein complex disassembly | 20436456 |
Hgene | BNIP3 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process | 20436456 |
Hgene | BNIP3 | GO:0045837 | negative regulation of membrane potential | 10891486 |
Hgene | BNIP3 | GO:0046902 | regulation of mitochondrial membrane permeability | 10891486 |
Hgene | BNIP3 | GO:0051607 | defense response to virus | 9973195 |
Hgene | BNIP3 | GO:0072593 | reactive oxygen species metabolic process | 10891486 |
Hgene | BNIP3 | GO:0090141 | positive regulation of mitochondrial fission | 20436456 |
Hgene | BNIP3 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 20436456 |
Hgene | BNIP3 | GO:0097345 | mitochondrial outer membrane permeabilization | 18371312 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | CESC | TCGA-ZJ-A8QO-01A | BNIP3 | chr10 | 133795265 | - | PPP2R2D | chr10 | 133769188 | + |
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Fusion Gene ORF analysis for BNIP3-PPP2R2D |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000368636 | ENST00000470416 | BNIP3 | chr10 | 133795265 | - | PPP2R2D | chr10 | 133769188 | + |
5CDS-3UTR | ENST00000540159 | ENST00000470416 | BNIP3 | chr10 | 133795265 | - | PPP2R2D | chr10 | 133769188 | + |
Frame-shift | ENST00000368636 | ENST00000422256 | BNIP3 | chr10 | 133795265 | - | PPP2R2D | chr10 | 133769188 | + |
Frame-shift | ENST00000540159 | ENST00000422256 | BNIP3 | chr10 | 133795265 | - | PPP2R2D | chr10 | 133769188 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for BNIP3-PPP2R2D |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
BNIP3 | chr10 | 133795264 | - | PPP2R2D | chr10 | 133769187 | + | 1.01E-06 | 0.9999989 |
BNIP3 | chr10 | 133795264 | - | PPP2R2D | chr10 | 133769187 | + | 1.01E-06 | 0.9999989 |
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Fusion Protein Features for BNIP3-PPP2R2D |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:133795265/:133769188) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for BNIP3-PPP2R2D |
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Fusion Gene PPI Analysis for BNIP3-PPP2R2D |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BNIP3-PPP2R2D |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BNIP3-PPP2R2D |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BNIP3 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Hgene | BNIP3 | C0026764 | Multiple Myeloma | 1 | CTD_human |
Hgene | BNIP3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | BNIP3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | BNIP3 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | BNIP3 | C0677050 | Manganese Poisoning | 1 | CTD_human |
Hgene | BNIP3 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |