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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SOX5-LOH12CR2 (FusionGDB2 ID:HG6660TG503693) |
Fusion Gene Summary for SOX5-LOH12CR2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SOX5-LOH12CR2 | Fusion gene ID: hg6660tg503693 | Hgene | Tgene | Gene symbol | SOX5 | LOH12CR2 | Gene ID | 6660 | 503693 |
| Gene name | SRY-box transcription factor 5 | loss of heterozygosity on chromosome 12, region 2 | |
| Synonyms | L-SOX5|L-SOX5B|L-SOX5F|LAMSHF | LOH2CR12 | |
| Cytomap | ('SOX5')('LOH12CR2') 12p12.1 | 12p13.2 | |
| Type of gene | protein-coding | ncRNA | |
| Description | transcription factor SOX-5SRY (sex determining region Y)-box 5SRY-box 5 | loss of heterozygosity, 12, chromosomal region 2 (non-protein coding) | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000309359, ENST00000381381, ENST00000451604, ENST00000537393, ENST00000541536, ENST00000545921, ENST00000546136, ENST00000396007, ENST00000441133, ENST00000536850, ENST00000541847, | ||
| Fusion gene scores | * DoF score | 19 X 15 X 10=2850 | 3 X 2 X 3=18 |
| # samples | 19 | 3 | |
| ** MAII score | log2(19/2850*10)=-3.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SOX5 [Title/Abstract] AND LOH12CR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SOX5(23757321)-LOH12CR2(12509739), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | SOX5-LOH12CR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SOX5-LOH12CR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SOX5-LOH12CR2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SOX5 | GO:0032332 | positive regulation of chondrocyte differentiation | 21401405 |
| Hgene | SOX5 | GO:0061036 | positive regulation of cartilage development | 21401405 |
| Hgene | SOX5 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 21401405 |
| Hgene | SOX5 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation | 21401405 |
| Fusion gene breakpoints across SOX5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across LOH12CR2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LGG | TCGA-DU-7007 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
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Fusion Gene ORF analysis for SOX5-LOH12CR2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000309359 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| Frame-shift | ENST00000381381 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| In-frame | ENST00000451604 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| In-frame | ENST00000537393 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| In-frame | ENST00000541536 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| In-frame | ENST00000545921 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| In-frame | ENST00000546136 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| intron-3CDS | ENST00000396007 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| intron-3CDS | ENST00000441133 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| intron-3CDS | ENST00000536850 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| intron-3CDS | ENST00000541847 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000546136 | SOX5 | chr12 | 23757321 | - | ENST00000381800 | LOH12CR2 | chr12 | 12509739 | - | 2526 | 1128 | 3 | 1220 | 405 |
| ENST00000451604 | SOX5 | chr12 | 23757321 | - | ENST00000381800 | LOH12CR2 | chr12 | 12509739 | - | 2664 | 1266 | 48 | 1358 | 436 |
| ENST00000537393 | SOX5 | chr12 | 23757321 | - | ENST00000381800 | LOH12CR2 | chr12 | 12509739 | - | 2503 | 1105 | 31 | 1197 | 388 |
| ENST00000541536 | SOX5 | chr12 | 23757321 | - | ENST00000381800 | LOH12CR2 | chr12 | 12509739 | - | 2527 | 1129 | 4 | 1221 | 405 |
| ENST00000545921 | SOX5 | chr12 | 23757321 | - | ENST00000381800 | LOH12CR2 | chr12 | 12509739 | - | 2688 | 1290 | 156 | 1382 | 408 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000546136 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - | 0.008357604 | 0.99164236 |
| ENST00000451604 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - | 0.011222279 | 0.9887777 |
| ENST00000537393 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - | 0.008184182 | 0.99181587 |
| ENST00000541536 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - | 0.008423621 | 0.9915764 |
| ENST00000545921 | ENST00000381800 | SOX5 | chr12 | 23757321 | - | LOH12CR2 | chr12 | 12509739 | - | 0.011996709 | 0.98800325 |
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Fusion Genomic Features for SOX5-LOH12CR2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for SOX5-LOH12CR2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:23757321/chr12:12509739) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000309359 | - | 9 | 15 | 193_274 | 375 | 751.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000381381 | - | 9 | 13 | 193_274 | 375 | 643.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000451604 | - | 9 | 15 | 193_274 | 388 | 764.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000541536 | - | 8 | 12 | 193_274 | 375 | 643.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000545921 | - | 9 | 15 | 193_274 | 378 | 754.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000546136 | - | 8 | 14 | 193_274 | 375 | 751.0 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000309359 | - | 9 | 15 | 448_515 | 375 | 751.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000381381 | - | 9 | 13 | 448_515 | 375 | 643.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000396007 | - | 1 | 7 | 193_274 | 0 | 378.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000396007 | - | 1 | 7 | 448_515 | 0 | 378.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000451604 | - | 9 | 15 | 448_515 | 388 | 764.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000541536 | - | 8 | 12 | 448_515 | 375 | 643.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000545921 | - | 9 | 15 | 448_515 | 378 | 754.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000546136 | - | 8 | 14 | 448_515 | 375 | 751.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000309359 | - | 9 | 15 | 556_624 | 375 | 751.0 | DNA binding | HMG box |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000381381 | - | 9 | 13 | 556_624 | 375 | 643.0 | DNA binding | HMG box |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000396007 | - | 1 | 7 | 556_624 | 0 | 378.0 | DNA binding | HMG box |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000451604 | - | 9 | 15 | 556_624 | 388 | 764.0 | DNA binding | HMG box |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000541536 | - | 8 | 12 | 556_624 | 375 | 643.0 | DNA binding | HMG box |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000545921 | - | 9 | 15 | 556_624 | 378 | 754.0 | DNA binding | HMG box |
| Hgene | SOX5 | chr12:23757321 | chr12:12509739 | ENST00000546136 | - | 8 | 14 | 556_624 | 375 | 751.0 | DNA binding | HMG box |
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Fusion Gene Sequence for SOX5-LOH12CR2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >85331_85331_1_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000451604_LOH12CR2_chr12_12509739_ENST00000381800_length(transcript)=2664nt_BP=1266nt GAGAAAATCAATTGGTTTAGAAGGTTTGGACTCACTTGACAGGTTCAGTTGGAGACGATCATAGGTGGCTGCTGTGACAAAGGGAAATTG TGCTTTTCCAGCATGCTTACTGACCCTGATTTACCTCAGGAGTTTGAAAGGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCA GATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTG AGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGCTGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAG CACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGT GGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTG AAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAG CTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATC AACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAG CAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAG CAACAGATCCAGGTTCAAGGTCAGCTGCCGCCATTAATGATTCCCGTATTCCCTCCTGATCAACGGACACTGGCTGCAGCTGCCCAGCAA GGATTCCTCCTCCCTCCAGGCTTCAGCTATAAGGCTGGATGTAGTGACCCTTACCCTGTTCAGCTGATCCCAACTACCATGGCAGCTGCT GCCGCAGCAACACCAGGCTTAGGCCCACTCCAACTGCAGCAGTTATATGCTGCCCAGCTAGCTGCAATGCAGGTATCTCCAGGAGGGAAG CTGCCAGGCATACCCCAAGGCAACCTTGGTGCTGCTGTATCTCCTACCAGCATTCACACAGACAAGAGCACAAACAGCCCACCACCCAAA AGCAAGATGGAGAAAGAAACGCTAGATAGACCCAGGATTCGAACCCACAACAGCTTGGATGCAAAGCTCATTTTGAATTCTGAAGAGCTG GGAGTTTAGCAGTGGACGACCAAACAAAAAAATACCAGAAGACGGTGAAAGCAGCAGCTGGAAATGAGAGAAAAATTAAGAAATAGAAAA TGCTGTTTCATGTATTAGGGAGTGCACATCTTTAAAGAGAAGTGAAGAACCTTTTTGGCTAGGCGCTTTCTGGGGACCTTGGCAGTTATC AACAAGTCACTCTGAAACTAACAGAAGGTGAGGAGGGAGTAATCCAGAAAGGAAACTGCCATTTTTGCTAGGGCAAGAAAGTAGACCTAG CAATGCAATGCCATCAAGGAGTTAGCTGGCTCTAGCGTTCTCCGAACTTTGCAACTCATTTTATATTACATTGTCTGCGTCAAGAAATTT CAAGTAAATGCCTTGAGATTTTATATGTATAAAATGTAGTCTCTGGCCAGGCGGGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGG CTGAGGCGAGTAGATCACGATGTCAGGAGATCAAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAATTA GCCGGGCATGATGGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGACAGGAGAATGGTGTGAACCCGGGAGGCAGAGCTTGCAGT GAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAGTCTCAGAAGAA GTGTCAAGTTGACTAAATGATTTTTAAGTCCCTTCCACTCTACTATATCACAATAATTTCCCCTATTTTACCTTATTTAATTTTCACAAC AACCCTGCAGCCTGTAAGTAGGTGACTCCTCCATGGTCAGCAGGTGGTCAGTGGTCGAACTATTTAGGACTATCTGATGCTCTTTCCTCT GCTCACCATTGCAATACAATGAGAAAAATGCAAATGAATCTAAGTACAGTGTTCTCTGGGAATATGAAGATAGAACTAAAAACTGCCTGA GAGATCAGGGCAGGCTTCTAGAAAGTTGTGTCTAACTAGTCTTGAGGTTTACATAAACCACACCAGGCTGATGGGACTGGGAAGGGCCCA CTAAGCAGTGAGACCATTCCCTTTTGGAGAGTCCTTGCATCCCCTCCCAGATTTCCTCTTTGAGGGGAAGGTGAGAGAGGAGGTAAAAGG GGTGAGGAATGGAGAATAACTCATTCTGGTTCTTGTTTCCCCTTTTCCACATAAAAGTATATTTGTCTTGTGTTCCATACACCAGTCCAT ACTGATGTGATGGTGTTTTTTATGCTTCCTTTTGAATAAACATTTCATTCTTAA >85331_85331_1_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000451604_LOH12CR2_chr12_12509739_ENST00000381800_length(amino acids)=436AA_BP=399 METIIGGCCDKGKLCFSSMLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSL LTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEET PSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQ QQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLY AAQLAAMQVSPGGKLPGIPQGNLGAAVSPTSIHTDKSTNSPPPKSKMEKETLDRPRIRTHNSLDAKLILNSEELGV -------------------------------------------------------------- >85331_85331_2_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000537393_LOH12CR2_chr12_12509739_ENST00000381800_length(transcript)=2503nt_BP=1105nt GATCATAGGTGGCTGCTGTGACAAAGGGAAATTGTGCTTTTCCAGCATGCTTACTGACCCTGATTTACCTCAGGAGTTTGAAAGGATGTC TTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGA CGGGCTCCCAGCCTTTCACCTTCCCTTGCATGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACCTCACC TCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGTTTAGC TGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTACTCTC AAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAAGAAAG GCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCCTCTCA GATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAACAACA CAAAATCAATTTGCTCCAGCAACAGATCCAGGTTCAAGGTCAGCTGCCGCCATTAATGATTCCCGTATTCCCTCCTGATCAACGGACACT GGCTGCAGCTGCCCAGCAAGGATTCCTCCTCCCTCCAGGCTTCAGCTATAAGGCTGGATGTAGTGACCCTTACCCTGTTCAGCTGATCCC AACTACCATGGCAGCTGCTGCCGCAGCAACACCAGGCTTAGGCCCACTCCAACTGCAGCAGTTATATGCTGCCCAGCTAGCTGCAATGCA GGTATCTCCAGGAGGGAAGCTGCCAGGCATACCCCAAGGCAACCTTGGTGCTGCTGTATCTCCTACCAGCATTCACACAGACAAGAGCAC AAACAGCCCACCACCCAAAAGCAAGATGGAGAAAGAAACGCTAGATAGACCCAGGATTCGAACCCACAACAGCTTGGATGCAAAGCTCAT TTTGAATTCTGAAGAGCTGGGAGTTTAGCAGTGGACGACCAAACAAAAAAATACCAGAAGACGGTGAAAGCAGCAGCTGGAAATGAGAGA AAAATTAAGAAATAGAAAATGCTGTTTCATGTATTAGGGAGTGCACATCTTTAAAGAGAAGTGAAGAACCTTTTTGGCTAGGCGCTTTCT GGGGACCTTGGCAGTTATCAACAAGTCACTCTGAAACTAACAGAAGGTGAGGAGGGAGTAATCCAGAAAGGAAACTGCCATTTTTGCTAG GGCAAGAAAGTAGACCTAGCAATGCAATGCCATCAAGGAGTTAGCTGGCTCTAGCGTTCTCCGAACTTTGCAACTCATTTTATATTACAT TGTCTGCGTCAAGAAATTTCAAGTAAATGCCTTGAGATTTTATATGTATAAAATGTAGTCTCTGGCCAGGCGGGGTGGCTCACGCCTGTA ATCCCAGCACTTTGGGAGGCTGAGGCGAGTAGATCACGATGTCAGGAGATCAAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTAC TAAAAAATACAAAAAATTAGCCGGGCATGATGGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGACAGGAGAATGGTGTGAACCC GGGAGGCAGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAA AAAAAAAGTCTCAGAAGAAGTGTCAAGTTGACTAAATGATTTTTAAGTCCCTTCCACTCTACTATATCACAATAATTTCCCCTATTTTAC CTTATTTAATTTTCACAACAACCCTGCAGCCTGTAAGTAGGTGACTCCTCCATGGTCAGCAGGTGGTCAGTGGTCGAACTATTTAGGACT ATCTGATGCTCTTTCCTCTGCTCACCATTGCAATACAATGAGAAAAATGCAAATGAATCTAAGTACAGTGTTCTCTGGGAATATGAAGAT AGAACTAAAAACTGCCTGAGAGATCAGGGCAGGCTTCTAGAAAGTTGTGTCTAACTAGTCTTGAGGTTTACATAAACCACACCAGGCTGA TGGGACTGGGAAGGGCCCACTAAGCAGTGAGACCATTCCCTTTTGGAGAGTCCTTGCATCCCCTCCCAGATTTCCTCTTTGAGGGGAAGG TGAGAGAGGAGGTAAAAGGGGTGAGGAATGGAGAATAACTCATTCTGGTTCTTGTTTCCCCTTTTCCACATAAAAGTATATTTGTCTTGT GTTCCATACACCAGTCCATACTGATGTGATGGTGTTTTTTATGCTTCCTTTTGAATAAACATTTCATTCTTAA >85331_85331_2_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000537393_LOH12CR2_chr12_12509739_ENST00000381800_length(amino acids)=388AA_BP=351 MCFSSMLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHEVDGNKVMSSFAPHNSSTSPQKAEEGGRQS GESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLT SLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLL PPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGAAVSPTSIHTDKSTNSPPPKSKME KETLDRPRIRTHNSLDAKLILNSEELGV -------------------------------------------------------------- >85331_85331_3_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000541536_LOH12CR2_chr12_12509739_ENST00000381800_length(transcript)=2527nt_BP=1129nt CAGGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGA GGAGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCT GCTGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGC CCCACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCC TGAACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAAC CCCCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCC CGAGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGA GCAGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCA GCAGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTTCAAGGTCAGCTGCCGCCATTAATGATTCCCGT ATTCCCTCCTGATCAACGGACACTGGCTGCAGCTGCCCAGCAAGGATTCCTCCTCCCTCCAGGCTTCAGCTATAAGGCTGGATGTAGTGA CCCTTACCCTGTTCAGCTGATCCCAACTACCATGGCAGCTGCTGCCGCAGCAACACCAGGCTTAGGCCCACTCCAACTGCAGCAGTTATA TGCTGCCCAGCTAGCTGCAATGCAGGTATCTCCAGGAGGGAAGCTGCCAGGCATACCCCAAGGCAACCTTGGTGCTGCTGTATCTCCTAC CAGCATTCACACAGACAAGAGCACAAACAGCCCACCACCCAAAAGCAAGATGGAGAAAGAAACGCTAGATAGACCCAGGATTCGAACCCA CAACAGCTTGGATGCAAAGCTCATTTTGAATTCTGAAGAGCTGGGAGTTTAGCAGTGGACGACCAAACAAAAAAATACCAGAAGACGGTG AAAGCAGCAGCTGGAAATGAGAGAAAAATTAAGAAATAGAAAATGCTGTTTCATGTATTAGGGAGTGCACATCTTTAAAGAGAAGTGAAG AACCTTTTTGGCTAGGCGCTTTCTGGGGACCTTGGCAGTTATCAACAAGTCACTCTGAAACTAACAGAAGGTGAGGAGGGAGTAATCCAG AAAGGAAACTGCCATTTTTGCTAGGGCAAGAAAGTAGACCTAGCAATGCAATGCCATCAAGGAGTTAGCTGGCTCTAGCGTTCTCCGAAC TTTGCAACTCATTTTATATTACATTGTCTGCGTCAAGAAATTTCAAGTAAATGCCTTGAGATTTTATATGTATAAAATGTAGTCTCTGGC CAGGCGGGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGAGTAGATCACGATGTCAGGAGATCAAGACCATCCTGGCT AACATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAATTAGCCGGGCATGATGGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCT GAGACAGGAGAATGGTGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGA CTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAGTCTCAGAAGAAGTGTCAAGTTGACTAAATGATTTTTAAGTCCCTTCCACTCTACTATA TCACAATAATTTCCCCTATTTTACCTTATTTAATTTTCACAACAACCCTGCAGCCTGTAAGTAGGTGACTCCTCCATGGTCAGCAGGTGG TCAGTGGTCGAACTATTTAGGACTATCTGATGCTCTTTCCTCTGCTCACCATTGCAATACAATGAGAAAAATGCAAATGAATCTAAGTAC AGTGTTCTCTGGGAATATGAAGATAGAACTAAAAACTGCCTGAGAGATCAGGGCAGGCTTCTAGAAAGTTGTGTCTAACTAGTCTTGAGG TTTACATAAACCACACCAGGCTGATGGGACTGGGAAGGGCCCACTAAGCAGTGAGACCATTCCCTTTTGGAGAGTCCTTGCATCCCCTCC CAGATTTCCTCTTTGAGGGGAAGGTGAGAGAGGAGGTAAAAGGGGTGAGGAATGGAGAATAACTCATTCTGGTTCTTGTTTCCCCTTTTC CACATAAAAGTATATTTGTCTTGTGTTCCATACACCAGTCCATACTGATGTGATGGTGTTTTTTATGCTTCCTTTTGAATAAACATTTCA TTCTTAA >85331_85331_3_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000541536_LOH12CR2_chr12_12509739_ENST00000381800_length(amino acids)=405AA_BP=368 MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAP HNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPE SLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVF PPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGAAVSPTS IHTDKSTNSPPPKSKMEKETLDRPRIRTHNSLDAKLILNSEELGV -------------------------------------------------------------- >85331_85331_4_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000545921_LOH12CR2_chr12_12509739_ENST00000381800_length(transcript)=2688nt_BP=1290nt AGTAGGAGTGGAGAGCGTGCGTGAGTGAGTGTGTGTGTGTGTGTGTGTGTGTGTGCATGCGTGTGTGAAGAATGCACACTATCTCCTGTT GGTAAGTGTGTGCTTACTCCCTGACCAGATGCTGCGGTGCACGGGGCAGCCACCATCTCTGCATGCATGTCTGTGATGTCTTCCAAGCGA CCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAGGAGAGTGACGGGCTCCCA GCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTGCTGACGCAAGAGACTTGT GGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCCCCACACAACTCATCTACC TCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCTGAACGGCGCAAGGGCAGT TTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACCCCCAGTATTGAAAAACTA CTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCCGAGAGCTTAGCTGAGAAA GAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAGCAGAAGAAACTAGCTGCC TCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAGCAGCAGCTTCTACAGCAA CAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTTCAAGGTCAGCTGCCGCCATTAATGATTCCCGTATTCCCTCCTGATCAACGG ACACTGGCTGCAGCTGCCCAGCAAGGATTCCTCCTCCCTCCAGGCTTCAGCTATAAGGCTGGATGTAGTGACCCTTACCCTGTTCAGCTG ATCCCAACTACCATGGCAGCTGCTGCCGCAGCAACACCAGGCTTAGGCCCACTCCAACTGCAGCAGTTATATGCTGCCCAGCTAGCTGCA ATGCAGGTATCTCCAGGAGGGAAGCTGCCAGGCATACCCCAAGGCAACCTTGGTGCTGCTGTATCTCCTACCAGCATTCACACAGACAAG AGCACAAACAGCCCACCACCCAAAAGCAAGATGGAGAAAGAAACGCTAGATAGACCCAGGATTCGAACCCACAACAGCTTGGATGCAAAG CTCATTTTGAATTCTGAAGAGCTGGGAGTTTAGCAGTGGACGACCAAACAAAAAAATACCAGAAGACGGTGAAAGCAGCAGCTGGAAATG AGAGAAAAATTAAGAAATAGAAAATGCTGTTTCATGTATTAGGGAGTGCACATCTTTAAAGAGAAGTGAAGAACCTTTTTGGCTAGGCGC TTTCTGGGGACCTTGGCAGTTATCAACAAGTCACTCTGAAACTAACAGAAGGTGAGGAGGGAGTAATCCAGAAAGGAAACTGCCATTTTT GCTAGGGCAAGAAAGTAGACCTAGCAATGCAATGCCATCAAGGAGTTAGCTGGCTCTAGCGTTCTCCGAACTTTGCAACTCATTTTATAT TACATTGTCTGCGTCAAGAAATTTCAAGTAAATGCCTTGAGATTTTATATGTATAAAATGTAGTCTCTGGCCAGGCGGGGTGGCTCACGC CTGTAATCCCAGCACTTTGGGAGGCTGAGGCGAGTAGATCACGATGTCAGGAGATCAAGACCATCCTGGCTAACATGGTGAAACCCCGTC TCTACTAAAAAATACAAAAAATTAGCCGGGCATGATGGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGACAGGAGAATGGTGTG AACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAA AAAAAAAAAAAAGTCTCAGAAGAAGTGTCAAGTTGACTAAATGATTTTTAAGTCCCTTCCACTCTACTATATCACAATAATTTCCCCTAT TTTACCTTATTTAATTTTCACAACAACCCTGCAGCCTGTAAGTAGGTGACTCCTCCATGGTCAGCAGGTGGTCAGTGGTCGAACTATTTA GGACTATCTGATGCTCTTTCCTCTGCTCACCATTGCAATACAATGAGAAAAATGCAAATGAATCTAAGTACAGTGTTCTCTGGGAATATG AAGATAGAACTAAAAACTGCCTGAGAGATCAGGGCAGGCTTCTAGAAAGTTGTGTCTAACTAGTCTTGAGGTTTACATAAACCACACCAG GCTGATGGGACTGGGAAGGGCCCACTAAGCAGTGAGACCATTCCCTTTTGGAGAGTCCTTGCATCCCCTCCCAGATTTCCTCTTTGAGGG GAAGGTGAGAGAGGAGGTAAAAGGGGTGAGGAATGGAGAATAACTCATTCTGGTTCTTGTTTCCCCTTTTCCACATAAAAGTATATTTGT CTTGTGTTCCATACACCAGTCCATACTGATGTGATGGTGTTTTTTATGCTTCCTTTTGAATAAACATTTCATTCTTAA >85331_85331_4_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000545921_LOH12CR2_chr12_12509739_ENST00000381800_length(amino acids)=408AA_BP=371 MSVMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSS FAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKG TPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMI PVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGAAVS PTSIHTDKSTNSPPPKSKMEKETLDRPRIRTHNSLDAKLILNSEELGV -------------------------------------------------------------- >85331_85331_5_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000546136_LOH12CR2_chr12_12509739_ENST00000381800_length(transcript)=2526nt_BP=1128nt AGGATGTCTTCCAAGCGACCAGCCTCTCCGTATGGGGAAGCAGATGGAGAGGTAGCCATGGTGACAAGCAGACAGAAAGTGGAAGAAGAG GAGAGTGACGGGCTCCCAGCCTTTCACCTTCCCTTGCATGTGAGTTTTCCCAACAAGCCTCACTCTGAGGAATTTCAGCCAGTTTCTCTG CTGACGCAAGAGACTTGTGGCCATAGGACTCCCACTTCTCAGCACAATACAATGGAAGTTGATGGCAATAAAGTTATGTCTTCATTTGCC CCACACAACTCATCTACCTCACCTCAGAAGGCAGAAGAAGGTGGGCGACAGAGTGGCGAGTCCTTGTCTAGTACAGCCCTGGGAACTCCT GAACGGCGCAAGGGCAGTTTAGCTGATGTTGTTGACACCTTGAAGCAGAGGAAAATGGAAGAGCTCATCAAAAACGAGCCGGAAGAAACC CCCAGTATTGAAAAACTACTCTCAAAGGACTGGAAAGACAAGCTTCTTGCAATGGGATCGGGGAACTTTGGCGAAATAAAAGGGACTCCC GAGAGCTTAGCTGAGAAAGAAAGGCAACTCATGGGTATGATCAACCAGCTGACCAGCCTCCGAGAGCAGCTGTTGGCTGCCCACGATGAG CAGAAGAAACTAGCTGCCTCTCAGATTGAGAAACAGCGTCAGCAAATGGAGCTGGCCAAGCAGCAACAAGAACAAATTGCAAGACAGCAG CAGCAGCTTCTACAGCAACAACACAAAATCAATTTGCTCCAGCAACAGATCCAGGTTCAAGGTCAGCTGCCGCCATTAATGATTCCCGTA TTCCCTCCTGATCAACGGACACTGGCTGCAGCTGCCCAGCAAGGATTCCTCCTCCCTCCAGGCTTCAGCTATAAGGCTGGATGTAGTGAC CCTTACCCTGTTCAGCTGATCCCAACTACCATGGCAGCTGCTGCCGCAGCAACACCAGGCTTAGGCCCACTCCAACTGCAGCAGTTATAT GCTGCCCAGCTAGCTGCAATGCAGGTATCTCCAGGAGGGAAGCTGCCAGGCATACCCCAAGGCAACCTTGGTGCTGCTGTATCTCCTACC AGCATTCACACAGACAAGAGCACAAACAGCCCACCACCCAAAAGCAAGATGGAGAAAGAAACGCTAGATAGACCCAGGATTCGAACCCAC AACAGCTTGGATGCAAAGCTCATTTTGAATTCTGAAGAGCTGGGAGTTTAGCAGTGGACGACCAAACAAAAAAATACCAGAAGACGGTGA AAGCAGCAGCTGGAAATGAGAGAAAAATTAAGAAATAGAAAATGCTGTTTCATGTATTAGGGAGTGCACATCTTTAAAGAGAAGTGAAGA ACCTTTTTGGCTAGGCGCTTTCTGGGGACCTTGGCAGTTATCAACAAGTCACTCTGAAACTAACAGAAGGTGAGGAGGGAGTAATCCAGA AAGGAAACTGCCATTTTTGCTAGGGCAAGAAAGTAGACCTAGCAATGCAATGCCATCAAGGAGTTAGCTGGCTCTAGCGTTCTCCGAACT TTGCAACTCATTTTATATTACATTGTCTGCGTCAAGAAATTTCAAGTAAATGCCTTGAGATTTTATATGTATAAAATGTAGTCTCTGGCC AGGCGGGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGAGTAGATCACGATGTCAGGAGATCAAGACCATCCTGGCTA ACATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAATTAGCCGGGCATGATGGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTG AGACAGGAGAATGGTGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGAC TCCGTCTCAAAAAAAAAAAAAAAAAAAAAAGTCTCAGAAGAAGTGTCAAGTTGACTAAATGATTTTTAAGTCCCTTCCACTCTACTATAT CACAATAATTTCCCCTATTTTACCTTATTTAATTTTCACAACAACCCTGCAGCCTGTAAGTAGGTGACTCCTCCATGGTCAGCAGGTGGT CAGTGGTCGAACTATTTAGGACTATCTGATGCTCTTTCCTCTGCTCACCATTGCAATACAATGAGAAAAATGCAAATGAATCTAAGTACA GTGTTCTCTGGGAATATGAAGATAGAACTAAAAACTGCCTGAGAGATCAGGGCAGGCTTCTAGAAAGTTGTGTCTAACTAGTCTTGAGGT TTACATAAACCACACCAGGCTGATGGGACTGGGAAGGGCCCACTAAGCAGTGAGACCATTCCCTTTTGGAGAGTCCTTGCATCCCCTCCC AGATTTCCTCTTTGAGGGGAAGGTGAGAGAGGAGGTAAAAGGGGTGAGGAATGGAGAATAACTCATTCTGGTTCTTGTTTCCCCTTTTCC ACATAAAAGTATATTTGTCTTGTGTTCCATACACCAGTCCATACTGATGTGATGGTGTTTTTTATGCTTCCTTTTGAATAAACATTTCAT TCTTAA >85331_85331_5_SOX5-LOH12CR2_SOX5_chr12_23757321_ENST00000546136_LOH12CR2_chr12_12509739_ENST00000381800_length(amino acids)=405AA_BP=368 MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAP HNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPE SLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVF PPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGAAVSPTS IHTDKSTNSPPPKSKMEKETLDRPRIRTHNSLDAKLILNSEELGV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SOX5-LOH12CR2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SOX5-LOH12CR2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SOX5-LOH12CR2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SOX5 | C0004238 | Atrial Fibrillation | 1 | CTD_human |
| Hgene | SOX5 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | SOX5 | C0235480 | Paroxysmal atrial fibrillation | 1 | CTD_human |
| Hgene | SOX5 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| Hgene | SOX5 | C2585653 | Persistent atrial fibrillation | 1 | CTD_human |
| Hgene | SOX5 | C3468561 | familial atrial fibrillation | 1 | CTD_human |
| Hgene | SOX5 | C4749915 | Developmental and speech delay due to SOX5 deficiency | 1 | ORPHANET |
| Hgene | SOX5 | C4755260 | 12p12.1 microdeletion syndrome | 1 | ORPHANET |
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