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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BOK-MEOX1 (FusionGDB2 ID:HG666TG4222)

Fusion Gene Summary for BOK-MEOX1

check button Fusion gene summary
Fusion gene informationFusion gene name: BOK-MEOX1
Fusion gene ID: hg666tg4222
HgeneTgene
Gene symbol

BOK

MEOX1

Gene ID

666

4222

Gene nameBCL2 family apoptosis regulator BOKmesenchyme homeobox 1
SynonymsBCL2L9|BOKLKFS2|MOX1
Cytomap('BOK')('MEOX1')

2q37.3

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionbcl-2-related ovarian killer proteinBCL2 related ovarian killerBOK, BCL2 family apoptosis regulatorbcl-2-like protein 9bcl2-L-9hBOKhomeobox protein MOX-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000318407, 
Fusion gene scores* DoF score3 X 2 X 2=122 X 3 X 2=12
# samples 43
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BOK [Title/Abstract] AND MEOX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBOK(242501891)-MEOX1(41721028), # samples:2
BOK(242501891)-MEOX1(41719400), # samples:2
Anticipated loss of major functional domain due to fusion event.BOK-MEOX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BOK-MEOX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BOK-MEOX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BOK-MEOX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BOK-MEOX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBOK

GO:0001836

release of cytochrome c from mitochondria

27505430

HgeneBOK

GO:0006915

apoptotic process

15102863

HgeneBOK

GO:0043065

positive regulation of apoptotic process

16302269|27505430

HgeneBOK

GO:1901382

regulation of chorionic trophoblast cell proliferation

19942931


check buttonFusion gene breakpoints across BOK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MEOX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8PE-01ABOKchr2

242501891

+MEOX1chr17

41719400

-
ChimerDB4STADTCGA-VQ-A8PE-01ABOKchr2

242501891

+MEOX1chr17

41721028

-
ChimerDB4STADTCGA-VQ-A8PEBOKchr2

242501891

+MEOX1chr17

41719400

-


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Fusion Gene ORF analysis for BOK-MEOX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000318407ENST00000329168BOKchr2

242501891

+MEOX1chr17

41721028

-
5CDS-intronENST00000318407ENST00000393661BOKchr2

242501891

+MEOX1chr17

41721028

-
5CDS-intronENST00000318407ENST00000549132BOKchr2

242501891

+MEOX1chr17

41721028

-
Frame-shiftENST00000318407ENST00000329168BOKchr2

242501891

+MEOX1chr17

41719400

-
Frame-shiftENST00000318407ENST00000393661BOKchr2

242501891

+MEOX1chr17

41719400

-
Frame-shiftENST00000318407ENST00000549132BOKchr2

242501891

+MEOX1chr17

41719400

-
In-frameENST00000318407ENST00000318579BOKchr2

242501891

+MEOX1chr17

41721028

-
In-frameENST00000318407ENST00000318579BOKchr2

242501891

+MEOX1chr17

41719400

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000318407BOKchr2242501891+ENST00000318579MEOX1chr1741721028-24696519012300
ENST00000318407BOKchr2242501891+ENST00000318579MEOX1chr1741719400-22966515491183

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318407ENST00000318579BOKchr2242501891+MEOX1chr1741721028-0.007238930.99276114
ENST00000318407ENST00000318579BOKchr2242501891+MEOX1chr1741719400-0.07873330.92126673

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Fusion Genomic Features for BOK-MEOX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BOK-MEOX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:242501891/chr17:41721028)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBOKchr2:242501891chr17:41719400ENST00000318407+3532_44116213.0MotifNote=BH4
HgeneBOKchr2:242501891chr17:41719400ENST00000318407+3566_82116213.0MotifNote=BH3
HgeneBOKchr2:242501891chr17:41721028ENST00000318407+3532_44116213.0MotifNote=BH4
HgeneBOKchr2:242501891chr17:41721028ENST00000318407+3566_82116213.0MotifNote=BH3
HgeneBOKchr2:242501891chr17:41719400ENST00000318407+3570_78116213.0RegionNuclear export signal
HgeneBOKchr2:242501891chr17:41721028ENST00000318407+3570_78116213.0RegionNuclear export signal
TgeneMEOX1chr2:242501891chr17:41719400ENST0000032916802171_230156185.0DNA bindingHomeobox
TgeneMEOX1chr2:242501891chr17:41719400ENST0000039366124171_23099140.0DNA bindingHomeobox
TgeneMEOX1chr2:242501891chr17:41721028ENST0000031857903171_230156255.0DNA bindingHomeobox
TgeneMEOX1chr2:242501891chr17:41721028ENST0000032916802171_2300185.0DNA bindingHomeobox
TgeneMEOX1chr2:242501891chr17:41721028ENST0000039366114171_23041140.0DNA bindingHomeobox

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBOKchr2:242501891chr17:41719400ENST00000318407+35112_131116213.0MotifNote=BH1
HgeneBOKchr2:242501891chr17:41719400ENST00000318407+35164_178116213.0MotifNote=BH2
HgeneBOKchr2:242501891chr17:41721028ENST00000318407+35112_131116213.0MotifNote=BH1
HgeneBOKchr2:242501891chr17:41721028ENST00000318407+35164_178116213.0MotifNote=BH2
HgeneBOKchr2:242501891chr17:41719400ENST00000318407+35189_209116213.0TransmembraneHelical
HgeneBOKchr2:242501891chr17:41721028ENST00000318407+35189_209116213.0TransmembraneHelical
TgeneMEOX1chr2:242501891chr17:41719400ENST0000031857913171_230214255.0DNA bindingHomeobox


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Fusion Gene Sequence for BOK-MEOX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10008_10008_1_BOK-MEOX1_BOK_chr2_242501891_ENST00000318407_MEOX1_chr17_41719400_ENST00000318579_length(transcript)=2296nt_BP=651nt
AGAAGGCCAAGCCCCAAGCCCAGCCTCTCGCCAGCTGGGAGTCGCGCGCTGCCCACCTCGCTGCCCAGGCCCCCGACGCCGCGGCAGGAG
CCCCCCAAGAGCGCGGGAAGCCCCGTGGACCTGGCGCTCCCGGCTCGGGCGTGGACGGGGCGGGCGCCGGGGCGGGGCGCGCGTCCTCGC
GGGTCTGAATGGAAGGGTCGAGGTCGTCGTCGGCGGCGAGCAGATCCTGAAGCCAGAACTCCACCCCGGCGCCCGCGCCATGCGGCGGGA
GAGGTGCGGCGCCCCCCACCCGCGTCGCCGCCATGGAGGTGCTGCGGCGCTCCTCGGTCTTCGCCGCCGAGATCATGGACGCCTTTGACC
GCTCGCCCACAGACAAGGAGCTGGTGGCCCAGGCCAAGGCGCTGGGCCGGGAGTACGTGCACGCGCGGCTGCTGCGCGCCGGCCTCTCCT
GGAGCGCGCCCGAGCGTGCCGCGCCGGTCCCGGGACGCCTGGCTGAGGTGTGCGCGGTGCTGCTGCGCCTGGGCGATGAGCTGGAGATGA
TCCGGCCCAGCGTCTACCGCAACGTGGCGCGTCAGCTGCACATCTCCCTGCAGTCTGAGCCTGTGGTGACCGATGCGTTCCTGGCCGTGG
CTGGCCACATCTTCTCTGCAGGTCAAAGTGTGGTTCCAGAACCGAAGGATGAAGTGGAAGCGTGTGAAGGGAGGTCAGCCCATCTCCCCC
AATGGGCAGGACCCTGAGGATGGGGACTCCACAGCCTCTCCAAGTTCAGAGTGAGATTCTGCATGGAGGAAAAATGACTAAGGACTGAGC
CCCCTACCCAACTACCCCCACCCCAATCCCACCTTCACCCTCTTCCTTCCCCAGCCAGGGCAGCCTCTCCACATCTTTCCCTGACTCTTG
GATATGAAACTGCCCAGCATTCCTGGGAGTCTTAGGATTTTCTAGGAAGTTCTGTCCAGCCTCTTAGCAGCCTCTTCCCTAGGGCCTTTG
CTCCCACACTCTCATGGAATCAGACAGAGATCCTACCGGGCCGGATGAATCTGGAAACAGCTTCAGAGATACTGCTTCTCAGCGTCTCTT
GGCTGCCACCCATGCCTCCTCCTACCGCTGTTCTCCTAGGTCAGCCAGGCCTCCTCCTGGTCTGGACACCACCTGGCCTGGTGGGAGAGG
AGCTTTGGAACCAGCTGGCGACTCGGAAAGTAAATGCTTCAAAAGGAAGGAAATGACAGAGACACACGCCCTTGCCCACCTTCCTCTGTA
GGCTGCACATCTGAGGCTTTGGGGCCCCTTAGTTGTCCCGAAACCCCAAGAAAAATCAGAATGAGGAGAGTCAAGGACAGCAACTCAGCT
GCTGCAAGCCAGAAACACATCCCTGTCTCCAAATTTGTTGGCTAAGTGGAGACACTTCTGAGAACTGACTAGAGAAGACAGAAAAATAGC
CCGATGTAGGTTTCGGTGTCCCCATATAGGCCCGTCCACACAGGCTTGACTGGGTGGACAAGAATGAACCCATGACAGCACCTGCTGCTT
CAAAATCAAAATCAATTTAGGGATACAGCAGGGGCTGTTGGGCTGTGCTCCAGAGAAAAGGAGCAGCTACTCCTTTTAAATCCACGATTT
CTGGATTGAAAACCTGTCCAGATGCTGAGTTGTTGGGCTGAACAACTAGGAGCTGAAAACAACGTAGAGGCTGGAAAGTGTCCCCTGCAT
TCTGGAGGGGAGGGGAGATAATAAGGAGGGCTGCTGGGTGAGGGCCTGGAGATGTGGAACCCTGGAGTGGAAGGTTCTCCAGTGACAGTG
TCCTGTGACTGCAAAAGGGGACAAGAAAATCCCTCTTCCTCCATGGGATGGATTTAAGCTCTTGCTGTGTGTTCTACAAATGCTGTTATT
GTGGGAGGAAATGCTAGGTTTTTGTGTGTGGACTGCCCAGACCTCAGCCAGGTCTTCTGGAGATGACATTTGAGGACTGATGGCCAAAGA
GCATGGGGGACTGAAGCCCTGGCTGCCTCAGCGCTCTGTCTCCCAACACCAGCTGGTGTTGCAGAGGGAGGTCAACGTGAGTTTGGATCT
CTTGTACGCAGATGTAATCATTCACATGTAAAAATAACCCCACCTCCCCACCCCAAAAAGGGCAAGAGCTGTGGAAAATGATTGCCAAAT
GAGATGGCTGGTTAGAGCATGATTTTTTCTAAAGCATACTTCATATATTTTCTTAAGATTACATCAAGCTAATTGTGCGAGCTCAATTCA

>10008_10008_1_BOK-MEOX1_BOK_chr2_242501891_ENST00000318407_MEOX1_chr17_41719400_ENST00000318579_length(amino acids)=183AA_BP=
MGRIISSSSPRRSSTAHTSARRPGTGAARSGALQERPARSSRACTYSRPSALAWATSSLSVGERSKASMISAAKTEERRSTSMAATRVGG
AAPLPPHGAGAGVEFWLQDLLAADDDLDPSIQTREDARPAPAPAPSTPEPGAPGPRGFPRSWGAPAAASGAWAARWAARDSQLARGWAWG

--------------------------------------------------------------
>10008_10008_2_BOK-MEOX1_BOK_chr2_242501891_ENST00000318407_MEOX1_chr17_41721028_ENST00000318579_length(transcript)=2469nt_BP=651nt
AGAAGGCCAAGCCCCAAGCCCAGCCTCTCGCCAGCTGGGAGTCGCGCGCTGCCCACCTCGCTGCCCAGGCCCCCGACGCCGCGGCAGGAG
CCCCCCAAGAGCGCGGGAAGCCCCGTGGACCTGGCGCTCCCGGCTCGGGCGTGGACGGGGCGGGCGCCGGGGCGGGGCGCGCGTCCTCGC
GGGTCTGAATGGAAGGGTCGAGGTCGTCGTCGGCGGCGAGCAGATCCTGAAGCCAGAACTCCACCCCGGCGCCCGCGCCATGCGGCGGGA
GAGGTGCGGCGCCCCCCACCCGCGTCGCCGCCATGGAGGTGCTGCGGCGCTCCTCGGTCTTCGCCGCCGAGATCATGGACGCCTTTGACC
GCTCGCCCACAGACAAGGAGCTGGTGGCCCAGGCCAAGGCGCTGGGCCGGGAGTACGTGCACGCGCGGCTGCTGCGCGCCGGCCTCTCCT
GGAGCGCGCCCGAGCGTGCCGCGCCGGTCCCGGGACGCCTGGCTGAGGTGTGCGCGGTGCTGCTGCGCCTGGGCGATGAGCTGGAGATGA
TCCGGCCCAGCGTCTACCGCAACGTGGCGCGTCAGCTGCACATCTCCCTGCAGTCTGAGCCTGTGGTGACCGATGCGTTCCTGGCCGTGG
CTGGCCACATCTTCTCTGCAGACAACCAGGAGAACAGAGGGAAGCCGGAGGGCAGCAGCAAAGCCCGCAAGGAGAGGACGGCCTTCACCA
AGGAGCAGCTGCGAGAGCTGGAGGCAGAGTTTGCCCATCATAACTACCTGACTCGGCTCCGCAGATATGAGATTGCGGTAAACCTGGACC
TCTCTGAGCGCCAGGTCAAAGTGTGGTTCCAGAACCGAAGGATGAAGTGGAAGCGTGTGAAGGGAGGTCAGCCCATCTCCCCCAATGGGC
AGGACCCTGAGGATGGGGACTCCACAGCCTCTCCAAGTTCAGAGTGAGATTCTGCATGGAGGAAAAATGACTAAGGACTGAGCCCCCTAC
CCAACTACCCCCACCCCAATCCCACCTTCACCCTCTTCCTTCCCCAGCCAGGGCAGCCTCTCCACATCTTTCCCTGACTCTTGGATATGA
AACTGCCCAGCATTCCTGGGAGTCTTAGGATTTTCTAGGAAGTTCTGTCCAGCCTCTTAGCAGCCTCTTCCCTAGGGCCTTTGCTCCCAC
ACTCTCATGGAATCAGACAGAGATCCTACCGGGCCGGATGAATCTGGAAACAGCTTCAGAGATACTGCTTCTCAGCGTCTCTTGGCTGCC
ACCCATGCCTCCTCCTACCGCTGTTCTCCTAGGTCAGCCAGGCCTCCTCCTGGTCTGGACACCACCTGGCCTGGTGGGAGAGGAGCTTTG
GAACCAGCTGGCGACTCGGAAAGTAAATGCTTCAAAAGGAAGGAAATGACAGAGACACACGCCCTTGCCCACCTTCCTCTGTAGGCTGCA
CATCTGAGGCTTTGGGGCCCCTTAGTTGTCCCGAAACCCCAAGAAAAATCAGAATGAGGAGAGTCAAGGACAGCAACTCAGCTGCTGCAA
GCCAGAAACACATCCCTGTCTCCAAATTTGTTGGCTAAGTGGAGACACTTCTGAGAACTGACTAGAGAAGACAGAAAAATAGCCCGATGT
AGGTTTCGGTGTCCCCATATAGGCCCGTCCACACAGGCTTGACTGGGTGGACAAGAATGAACCCATGACAGCACCTGCTGCTTCAAAATC
AAAATCAATTTAGGGATACAGCAGGGGCTGTTGGGCTGTGCTCCAGAGAAAAGGAGCAGCTACTCCTTTTAAATCCACGATTTCTGGATT
GAAAACCTGTCCAGATGCTGAGTTGTTGGGCTGAACAACTAGGAGCTGAAAACAACGTAGAGGCTGGAAAGTGTCCCCTGCATTCTGGAG
GGGAGGGGAGATAATAAGGAGGGCTGCTGGGTGAGGGCCTGGAGATGTGGAACCCTGGAGTGGAAGGTTCTCCAGTGACAGTGTCCTGTG
ACTGCAAAAGGGGACAAGAAAATCCCTCTTCCTCCATGGGATGGATTTAAGCTCTTGCTGTGTGTTCTACAAATGCTGTTATTGTGGGAG
GAAATGCTAGGTTTTTGTGTGTGGACTGCCCAGACCTCAGCCAGGTCTTCTGGAGATGACATTTGAGGACTGATGGCCAAAGAGCATGGG
GGACTGAAGCCCTGGCTGCCTCAGCGCTCTGTCTCCCAACACCAGCTGGTGTTGCAGAGGGAGGTCAACGTGAGTTTGGATCTCTTGTAC
GCAGATGTAATCATTCACATGTAAAAATAACCCCACCTCCCCACCCCAAAAAGGGCAAGAGCTGTGGAAAATGATTGCCAAATGAGATGG
CTGGTTAGAGCATGATTTTTTCTAAAGCATACTTCATATATTTTCTTAAGATTACATCAAGCTAATTGTGCGAGCTCAATTCACTTTGTA

>10008_10008_2_BOK-MEOX1_BOK_chr2_242501891_ENST00000318407_MEOX1_chr17_41721028_ENST00000318579_length(amino acids)=300AA_BP=1
MPIGGDGLTSLHTLPLHPSVLEPHFDLALREVQVYRNLISAEPSQVVMMGKLCLQLSQLLLGEGRPLLAGFAAALRLPSVLLVVCREDVA
SHGQERIGHHRLRLQGDVQLTRHVAVDAGPDHLQLIAQAQQHRAHLSQASRDRRGTLGRAPGEAGAQQPRVHVLPAQRLGLGHQLLVCGR
AVKGVHDLGGEDRGAPQHLHGGDAGGGRRTSPAAWRGRRGGVLASGSARRRRRPRPFHSDPRGRAPRPGARPVHARAGSARSTGLPALLG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BOK-MEOX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BOK-MEOX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BOK-MEOX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0022738Klippel-Feil Syndrome1GENOMICS_ENGLAND;ORPHANET
TgeneC0162820Dermatitis, Allergic Contact1CTD_human
TgeneC1859209Klippel Feil syndrome recessive type1CTD_human;GENOMICS_ENGLAND