![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:BPHL-TRPV1 (FusionGDB2 ID:HG670TG7442) |
Fusion Gene Summary for BPHL-TRPV1 |
![]() |
Fusion gene information | Fusion gene name: BPHL-TRPV1 | Fusion gene ID: hg670tg7442 | Hgene | Tgene | Gene symbol | BPHL | TRPV1 | Gene ID | 670 | 7442 |
Gene name | biphenyl hydrolase like | transient receptor potential cation channel subfamily V member 1 | |
Synonyms | BPH-RP|MCNAA|VACVASE | VR1 | |
Cytomap | ('BPHL')('TRPV1') 6p25.2 | 17p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | valacyclovir hydrolasebiphenyl hydrolase-like (serine hydrolase)biphenyl hydrolase-related proteinbreast epithelial mucin-associated antigenvalacyclovirase | transient receptor potential cation channel subfamily V member 1OTRPC1capsaicin receptorosm-9-like TRP channel 1transient receptor potential vanilloid 1atransient receptor potential vanilloid 1bvanilloid receptor subtype 1 | |
Modification date | 20200313 | 20200315 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000380379, ENST00000380368, ENST00000380375, ENST00000434640, ENST00000464040, | ||
Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 3 X 4 X 3=36 |
# samples | 4 | 3 | |
** MAII score | log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BPHL [Title/Abstract] AND TRPV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | BPHL(3119081)-TRPV1(3495677), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TRPV1 | GO:0034605 | cellular response to heat | 11226139 |
Tgene | TRPV1 | GO:0050955 | thermoception | 10201375 |
Tgene | TRPV1 | GO:0071468 | cellular response to acidic pH | 11226139 |
Tgene | TRPV1 | GO:0098703 | calcium ion import across plasma membrane | 11226139 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-8080-01A | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
Top |
Fusion Gene ORF analysis for BPHL-TRPV1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000380379 | ENST00000174621 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5CDS-5UTR | ENST00000380379 | ENST00000399756 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5CDS-5UTR | ENST00000380379 | ENST00000399759 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5CDS-5UTR | ENST00000380379 | ENST00000571088 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5CDS-intron | ENST00000380379 | ENST00000310522 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5CDS-intron | ENST00000380379 | ENST00000425167 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5CDS-intron | ENST00000380379 | ENST00000576351 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-5UTR | ENST00000380368 | ENST00000174621 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-5UTR | ENST00000380368 | ENST00000399756 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-5UTR | ENST00000380368 | ENST00000399759 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-5UTR | ENST00000380368 | ENST00000571088 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-5UTR | ENST00000380375 | ENST00000174621 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-5UTR | ENST00000380375 | ENST00000399756 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-5UTR | ENST00000380375 | ENST00000399759 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-5UTR | ENST00000380375 | ENST00000571088 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-intron | ENST00000380368 | ENST00000310522 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-intron | ENST00000380368 | ENST00000425167 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-intron | ENST00000380368 | ENST00000576351 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-intron | ENST00000380375 | ENST00000310522 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-intron | ENST00000380375 | ENST00000425167 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
5UTR-intron | ENST00000380375 | ENST00000576351 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-5UTR | ENST00000434640 | ENST00000174621 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-5UTR | ENST00000434640 | ENST00000399756 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-5UTR | ENST00000434640 | ENST00000399759 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-5UTR | ENST00000434640 | ENST00000571088 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-5UTR | ENST00000464040 | ENST00000174621 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-5UTR | ENST00000464040 | ENST00000399756 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-5UTR | ENST00000464040 | ENST00000399759 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-5UTR | ENST00000464040 | ENST00000571088 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-intron | ENST00000434640 | ENST00000310522 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-intron | ENST00000434640 | ENST00000425167 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-intron | ENST00000434640 | ENST00000576351 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-intron | ENST00000464040 | ENST00000310522 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-intron | ENST00000464040 | ENST00000425167 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
intron-intron | ENST00000464040 | ENST00000576351 | BPHL | chr6 | 3119081 | + | TRPV1 | chr17 | 3495677 | - |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for BPHL-TRPV1 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Top |
Fusion Protein Features for BPHL-TRPV1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:3119081/:3495677) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for BPHL-TRPV1 |
![]() |
Top |
Fusion Gene PPI Analysis for BPHL-TRPV1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for BPHL-TRPV1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for BPHL-TRPV1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0020429 | Hyperalgesia | 4 | CTD_human | |
Tgene | C0030193 | Pain | 4 | CTD_human | |
Tgene | C0234230 | Pain, Burning | 4 | CTD_human | |
Tgene | C0234238 | Ache | 4 | CTD_human | |
Tgene | C0234254 | Radiating pain | 4 | CTD_human | |
Tgene | C0458247 | Allodynia | 4 | CTD_human | |
Tgene | C0458257 | Pain, Splitting | 4 | CTD_human | |
Tgene | C0458259 | Pain, Crushing | 4 | CTD_human | |
Tgene | C0751211 | Hyperalgesia, Primary | 4 | CTD_human | |
Tgene | C0751212 | Hyperalgesia, Secondary | 4 | CTD_human | |
Tgene | C0751213 | Tactile Allodynia | 4 | CTD_human | |
Tgene | C0751214 | Hyperalgesia, Thermal | 4 | CTD_human | |
Tgene | C0751407 | Pain, Migratory | 4 | CTD_human | |
Tgene | C0751408 | Suffering, Physical | 4 | CTD_human | |
Tgene | C2936719 | Mechanical Allodynia | 4 | CTD_human | |
Tgene | C0021368 | Inflammation | 2 | CTD_human | |
Tgene | C0004153 | Atherosclerosis | 1 | CTD_human | |
Tgene | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human | |
Tgene | C0005695 | Bladder Neoplasm | 1 | CTD_human | |
Tgene | C0006826 | Malignant Neoplasms | 1 | CTD_human | |
Tgene | C0010200 | Coughing | 1 | CTD_human | |
Tgene | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human | |
Tgene | C0014558 | Uncinate Epilepsy | 1 | CTD_human | |
Tgene | C0014852 | Esophageal Diseases | 1 | CTD_human | |
Tgene | C0014868 | Esophagitis | 1 | CTD_human | |
Tgene | C0018834 | Heartburn | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0027651 | Neoplasms | 1 | CTD_human | |
Tgene | C0028754 | Obesity | 1 | CTD_human | |
Tgene | C0030305 | Pancreatitis | 1 | CTD_human | |
Tgene | C0037383 | Sneezing | 1 | CTD_human | |
Tgene | C0086692 | Benign Neoplasm | 1 | CTD_human | |
Tgene | C0393672 | Epilepsy, Benign Psychomotor, Childhood | 1 | CTD_human | |
Tgene | C0393682 | Epilepsy, Lateral Temporal | 1 | CTD_human | |
Tgene | C1563937 | Atherogenesis | 1 | CTD_human |