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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BRAF-TRIM24 (FusionGDB2 ID:HG673TG8805)

Fusion Gene Summary for BRAF-TRIM24

Fusion gene summary

Fusion gene information	Fusion gene name: BRAF-TRIM24
	Fusion gene ID: hg673tg8805
		Hgene	Tgene
	Gene symbol	BRAF	TRIM24
	Gene ID	673	8805
	Gene name	B-Raf proto-oncogene, serine/threonine kinase	tripartite motif containing 24
	Synonyms	B-RAF1\|B-raf\|BRAF1\|NS7\|RAFB1	PTC6\|RNF82\|TF1A\|TIF1\|TIF1A\|TIF1ALPHA\|hTIF1
	Cytomap	('BRAF')('TRIM24') 7q34	7q33-q34
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene	transcription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1
	Modification date	20200329	20200313
	UniProtAcc	P15056	O15164
	Ensembl transtripts involved in fusion gene	ENST00000288602,	ENST00000288602,
Fusion gene scores	* DoF score	28 X 21 X 11=6468	10 X 9 X 7=630
	# samples	32	11
	** MAII score	log2(32/6468*10)=-4.3371758685863 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BRAF [Title/Abstract] AND TRIM24 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BRAF(140624366)-TRIM24(138258252), # samples:1
Anticipated loss of major functional domain due to fusion event.	BRAF-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BRAF-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BRAF-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BRAF-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRIM24-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRIM24-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BRAF	GO:0000186	activation of MAPKK activity	29433126
Hgene	BRAF	GO:0006468	protein phosphorylation	17563371
Hgene	BRAF	GO:0010828	positive regulation of glucose transmembrane transport	23010278
Hgene	BRAF	GO:0033138	positive regulation of peptidyl-serine phosphorylation	19667065
Hgene	BRAF	GO:0043066	negative regulation of apoptotic process	19667065
Hgene	BRAF	GO:0070374	positive regulation of ERK1 and ERK2 cascade	22065586
Hgene	BRAF	GO:0071277	cellular response to calcium ion	18567582
Hgene	BRAF	GO:0090150	establishment of protein localization to membrane	23010278
Tgene	TRIM24	GO:0016567	protein ubiquitination	19556538
Tgene	TRIM24	GO:0071391	cellular response to estrogen stimulus	21164480

Fusion gene breakpoints across BRAF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIM24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	READ	TCGA-F5-6464-01A	BRAF	chr7	140624366	-	TRIM24	chr7	138258252	+

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Fusion Gene ORF analysis for BRAF-TRIM24

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000288602	ENST00000497516	BRAF	chr7	140624366	-	TRIM24	chr7	138258252	+
In-frame	ENST00000288602	ENST00000343526	BRAF	chr7	140624366	-	TRIM24	chr7	138258252	+
In-frame	ENST00000288602	ENST00000415680	BRAF	chr7	140624366	-	TRIM24	chr7	138258252	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000288602

BRAF

chr7

140624366

ENST00000343526

TRIM24

chr7

138258252

6516

199

1473

470

ENST00000288602

BRAF

chr7

140624366

ENST00000415680

TRIM24

chr7

138258252

2108

199

1473

470

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000288602	ENST00000343526	BRAF	chr7	140624366	-	TRIM24	chr7	138258252	+	0.00017269	0.9998273
ENST00000288602	ENST00000415680	BRAF	chr7	140624366	-	TRIM24	chr7	138258252	+	0.000462664	0.99953735

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Fusion Genomic Features for BRAF-TRIM24

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BRAF	chr7	140624365	-	TRIM24	chr7	138258251	+	1.12E-09	1
BRAF	chr7	140624365	-	TRIM24	chr7	138258251	+	1.12E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BRAF-TRIM24

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:140624366/chr7:138258252)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BRAF P15056	TRIM24 O15164
FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269\|PubMed:1508179, ECO:0000269\|PubMed:21441910, ECO:0000269\|PubMed:29433126, ECO:0000305}.	FUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250, ECO:0000269\|PubMed:16322096, ECO:0000269\|PubMed:19556538, ECO:0000269\|PubMed:21164480}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BRAF

chr7:140624366

chr7:138258252

ENST00000288602

6_11

767.0

Compositional bias

Note=Poly-Gly

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

932_987

626

1051.0

Domain

Bromo

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

932_987

592

1017.0

Domain

Bromo

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

891_907

626

1051.0

Motif

Nuclear localization signal

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

891_907

592

1017.0

Motif

Nuclear localization signal

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

754_779

626

1051.0

Region

Note=Nuclear receptor binding site (NRBS)

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

754_779

592

1017.0

Region

Note=Nuclear receptor binding site (NRBS)

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

826_873

626

1051.0

Zinc finger

PHD-type

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

826_873

592

1017.0

Zinc finger

PHD-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BRAF

chr7:140624366

chr7:138258252

ENST00000288602

122_129

767.0

Compositional bias

Note=Poly-Ser

Hgene

BRAF

chr7:140624366

chr7:138258252

ENST00000288602

428_432

767.0

Compositional bias

Note=Poly-Ser

Hgene

BRAF

chr7:140624366

chr7:138258252

ENST00000288602

155_227

767.0

Domain

RBD

Hgene

BRAF

chr7:140624366

chr7:138258252

ENST00000288602

457_717

767.0

Domain

Protein kinase

Hgene

BRAF

chr7:140624366

chr7:138258252

ENST00000288602

463_471

767.0

Nucleotide binding

ATP

Hgene

BRAF

chr7:140624366

chr7:138258252

ENST00000288602

234_280

767.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

289_359

626

1051.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

289_359

592

1017.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

344_347

626

1051.0

Compositional bias

Note=Poly-Gln

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

9_15

626

1051.0

Compositional bias

Note=Poly-Ala

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

344_347

592

1017.0

Compositional bias

Note=Poly-Gln

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

9_15

592

1017.0

Compositional bias

Note=Poly-Ala

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

158_211

626

1051.0

Zinc finger

B box-type 1

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

218_259

626

1051.0

Zinc finger

B box-type 2

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000343526

56_82

626

1051.0

Zinc finger

RING-type

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

158_211

592

1017.0

Zinc finger

B box-type 1

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

218_259

592

1017.0

Zinc finger

B box-type 2

Tgene

TRIM24

chr7:140624366

chr7:138258252

ENST00000415680

56_82

592

1017.0

Zinc finger

RING-type

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Fusion Gene Sequence for BRAF-TRIM24

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>10136_10136_1_BRAF-TRIM24_BRAF_chr7_140624366_ENST00000288602_TRIM24_chr7_138258252_ENST00000343526_length(transcript)=6516nt_BP=199nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGGAAAGATACTAATATAGATCATGGCCAGCC
AAGACCACCCTCAAACAGAACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTTGCAGGACCTGTTACTATGACTAGTGTACA
CCCCCCAATACGTTCACCTAGTGCCTCCAGCGTTGGAAGCCGAGGAAGCTCTGGCTCTTCCAGCAAACCAGCAGGAGCTGACTCTACACA
CAAAGTCCCAGTGGTCATGCTGGAGCCAATTCGAATAAAACAAGAAAACAGTGGACCACCGGAAAATTATGATTTCCCTGTTGTTATAGT
GAAGCAAGAATCAGATGAAGAATCTAGGCCTCAAAATGCCAATTATCCAAGAAGCATACTCACCTCCCTGCTCTTAAATAGCAGTCAGAG
CTCTACTTCTGAGGAGACTGTGCTAAGATCAGATGCCCCTGATAGTACAGGAGATCAACCTGGACTTCACCAGGACAATTCCTCAAATGG
AAAGTCTGAATGGTTGGATCCTTCCCAGAAGTCACCTCTTCATGTTGGAGAGACAAGGAAAGAGGATGACCCCAATGAGGACTGGTGTGC
AGTTTGTCAAAACGGAGGGGAACTCCTCTGCTGTGAAAAGTGCCCCAAAGTATTCCATCTTTCTTGTCATGTGCCCACATTGACAAATTT
TCCAAGTGGAGAGTGGATTTGCACTTTCTGCCGAGACTTATCTAAACCAGAAGTTGAATATGATTGTGATGCTCCCAGTCACAACTCAGA
AAAAAAGAAAACTGAAGGCCTTGTTAAGTTAACACCTATAGATAAAAGGAAGTGTGAGCGCCTACTTTTATTTCTTTACTGCCATGAAAT
GAGCCTGGCTTTTCAAGACCCTGTTCCTCTAACTGTGCCTGATTATTACAAAATAATTAAAAATCCAATGGATTTGTCAACCATCAAGAA
AAGACTACAAGAAGATTATTCCATGTACTCAAAACCTGAAGATTTTGTAGCTGATTTTAGATTGATCTTTCAAAACTGTGCTGAATTCAA
TGAGCCTGATTCAGAAGTAGCCAATGCTGGTATAAAACTTGAAAATTATTTTGAAGAACTTCTAAAGAACCTCTATCCAGAAAAAAGGTT
TCCCAAACCAGAATTCAGGAATGAATCAGAAGATAATAAATTTAGTGATGATTCAGATGATGACTTTGTACAGCCCCGGAAGAAACGCCT
CAAAAGCATTGAAGAACGCCAGTTGCTTAAATAATATGCAGCACCACTAGCTTGTGCTGGTTTTTAGATTTTTTTGTTTTCAAAAAAACA
TTTGTCAGTAATTTAACATCACTACAAAAAGAAGAGTTTGTGACTATTCTCATCTCTGTTTTGGACGTTTACTAGACTTTGATTTCCTTA
ATAGCCCATTTCTGTTAACCTCTTATCACTAAGAAAGAAAGGAAAGAAGGAGATGAATAGAAGAAAGAAAATGGAAAGAAGGAAAAAAGG
AGGATAGAAAAAGGATGGAAGAAAGAAGCATTGAAAACAAAGACATTCTTCCCACTTCTTGGATTTTTAAACCACAGTCTGGAGTGATAG
CTACTGTAGAAAGGAAATAGACTTTGTATGAACTCTTTAAGTTGAAAAGTAAAAAATATATGTGGTTTGGATGTGTGCTTTAATTCAGCT
TTAGAAATTAATACCACTACCCGTGAATTATATGGCCTGACAATATGAATTAGGTGTACTGTACTGAAGAACAGTACTCCACAAACATGG
GTGGTAACAAGAGTTCCATCCCAGGAGGCCAAACGGTGCAACAGAAGGGTAGGTTAGATGCTATTAAGAAGGCACTTAATAGTACATCAT
GTAAGATGGCAACTGTATTAAAGAAAAATCCGGAAAACAAATGTTTGATTTTTGTTTTTGTTTTTATCTTGTCTGTAGAGGTATTTTGGT
ATAGCAGGTTTTCAAGGCCATTTTTTATACATTTCTAGATCTAGATTTTCAACTTCTTCCACTGAGGGAAGTATATACATTTGGGTTTGC
TGTGTGTCTATGTGAGGTTTAATTGTACAGGTGATCCTTTTACAACAAGCCTCATTGTTTGCAGTATAGCTTTTAGTGGAACTACCCAAA
ATATAAATACAGCAGCGTGCACTGTATTTGATGTGAGGGTTCTTCATCATATACCCTACTGGGCATTAAATATAAGTTCCTCTGAAAGGG
ACTCGTTTTTGTGGTTTTCATCTGTCTATAATTTGGAATGAAAATGTGTTGTAGGATTTTGGGAGCAGGCAGCTGGGGGGAATTAATAGT
GATTTTTTTTTTTTCCTGAAGCATCTATCTCATGTTTTTCTTTTGAGAGTCAGAACATCAAACTTAATCTTTGATCTGACTTCTGATTTT
ATTCTTCTGATTGATTGATAGAGGTACAAAAGACTTATCTTCTGAGGACAAGCATATTCTTAATGTGCCAGACCTACCCGGTTCAGCTGA
TATAGATAGATAGATAGATAGAAGAAAATTGCTGTGCCATACATTAATCCAGCATTTGACACAATATCTAAATGGTTTGCCGAAGTTAAT
CTGTATTTATAAAACATTAACTGGAGTAAATTTTTCTCCTTAGGATGATAGAATAAAAAGAGCTCACTTGAAAGAAGGCTATTATTTGCA
TTATATCACCTGCCATAAATTTAACATAGAAGACTTGGTTTTATCTACATGGCTTTACTTCTTAAAGTGGAAAATATCCTGTGGCTAATT
CATTGGGTTTTCAGGTACTGCTAAAGATAAAATACAGGGAGAAAATAACTTGTTAGCAATAGATCCCCATTGTTTATATATATAGGTCTT
GTTCATAATATGTCAATTATGTATTGTTAAAAAGTCCTACTCACTTTTCAAATATGTGTTACATGGTAATGTTTGTCATTGTTGTTTTAA
AGTTGCATTTGACATTTGTTCTCCAAAGAGTGTTTGAACAGATTTTGATAACAGTGCATACACCTTTTGTCTTTTTTTGCTCCAGCATTT
TATTTTTAGCACAGCAGCTGTGGAGCTTTTGCTGATAATTTTATTGTTGGTATCTTAGAATACTGTTCGTCTGACAGTTTATTCTTCCAT
ACTTGTCTCCCAAGTTAAAACAGAGCAAAACAGATAAATTATTTTGAGAATCATCACAAAAGGGAGTTAGAACTTGTGAGACTAAAACTA
TAATTTCCTAAATGTGACTAATGAACCCCAAACTGTCACTATTACATTCAGTGCCATATTTATCTTTCAAAACAGTATTTGTTTCACCCT
AACCATCTTTGGCTGAATGAAAGGCAGTTGAGAACCATCTTTTGGTCATACATAATATAATTATATTAAAAGTAAAGATCGGGGCTGGGC
GCAGTGGCTCACACCTGCAATCCCACCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACAAAGTCAAGAGTTCGAGATCAGCCTGGCCAA
CATTGTGAAACCCCGCCTCTACAAAAAATACAAAAATTAGCCGGACATGGTGGCGTGCAACTGTAATCCCAACTACTCAGGAGGCTGAGA
CAGGAGAATCACTTGAACGCAGGAGGCAGAAGTTGCAGTGAGCCAAGATCTCACCATTGCACTCCAGCCTGAGTGACAGAGACTCAGTCT
CAAAAACAAAAAGTAAAGGTCTTGGGTTTCTCTCTGTAAATAGCCTTTGTGTAATGGTCTTTAGATTAATATCCTTTGACTTTATTAATA
AGTACCTGTGTGCCCAGGTGGATCTCAGCTAAGTCATCCTTAAATTCTGTTCAAATAGAAATAAACCATAAAATGAGCCTAACTATAACC
CACACTCACTTATCAAGCATTCCCCCAAAAGTTCAGTGCGATTCAGGTAACCTTGACCTAAACTTGTACACTCCGGTGTACATCTTTGAC
CATAAACTCTGGGAGATTTCCCTCTGGATTTGGGATCAGGAGCCCAGTAGGGCCCCATTGCTGAATGTTTATCACACTTCTGGCTAGGGC
TTATGGATGAGCAGACCACGTAGGAGCTAGGATTTACTCAGTTCCACCTCACTGACAGCTTTTCTAGGTGCCAAGCAACTGACTTTTCCT
GTGTAAGGAAGCCCAAGTACTTGACCAGTGATATATATGGCCATGGCAAAAGTATAAATGGATGGATGTAGACCATATTCAACGCAGAAT
ACATTTTAGATCGGTATCTGGCATTGTAATCATTTTGTCTTTTGAATTAACATGCCCTGCTTGTCTTTTCTGAATGGAAGGGTAGGAAAG
TGGAAGGTACTAAAAAGGAAAATGTAGTTTTAGTTTCTTTTCTAAGCTAAAGAACTGGCTTTACTACTGCTATATTTTACTACCACATAG
TAGTGTAGATGTAGTATAACTTGCTTAGGAATGCTTTCAAAAAGGTTACCTCCATAGTCAAAAAAAGGGGGAGTATACAGCTGATTGTTG
CATTTATGAAACTGCATTTCAATATGCTATGCTGTTACTGTGCTTAGACACTTCCTTACGTTTGAGTTCCAAGGAGAGAGAGTGAGAAGA
GGAACTCCTTTTGCTGAGCTCTGGTCCAAATTAATGTGAATCCCCAAAGTAAATTGCTGCATATGAACAACAGGTTTTAGGTTTAAATTG
AAGATACATTCATTTTATATGTATTTGTTGTGAATGAGAGAAATTGAGTGATCTGATTGGCCATTAAAATTATGGTGAATGGGTCGGGCG
CAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTAGATACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACAT
GGTGAAACCCCATCTCTACTAAAAATACCAAAATCACCAGGGTGTGGTGGCCCATGCCTGTAATCCTAGCTACTCGGGAGGCTGAGGCAG
GAGAATCGGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGTAGTCCAGCCTGGGTGTCAGAGCAAGACTCTGT
CACAAAAAGAAAAATTATGGGGAATGGCCGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACC
TGAAGTCAGGAGCTCAAGACCAGCCTGGCCAACATGGTGAAACCCCACCTCAACAGAATATACAAAAAAATTAGCTGGGTGTGGTGGCGG
GTGCCTGTAATCTCAGCTACTTTGGGATGCTGAGGCAGGAGAATAGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGTCGAGATTGCACC
ATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAATGGTGACCATGCGTTCAACCATATAATTTCTTAC
TGAAATTGAGCTCCTCCTTTTGAATAACCATGTACATATTTTTAAAAGTATTTTATAGCCCTATGTAAATTAATAGTTGATGTCTTTTTA
TAAATGTTTATTGCATATTCATCTTGAATGTGAATTTACTGTTGTAATTCACATACTGGTGTCATGTTTCTGAGTGAGAATAATGCTAGT
CAGTCAGATCACAGATTTTTCTCCATGAAGGTTTTACTTATTGAGAGGGACATCTGAGGCAGTAGTCTTCGTCTTTAATTTTTGGGGGCA
GATTGGTGCTTTGGTTTTAATAAAAACTAACTTTGATGGATTTTTACTGTCAATATTTTACCACAAGGATTTTTTAATAGAAAAATTACT
GAATGTTACTTCAGCAGAGTTCTATCTACTTTGAGTCTCCATTACTACTACTGTTGTTCCCCTAGCTGTAACATTGATCCATATAGGGGC
AAGCTACTAGTCCATAAATAGCTGTAATAGGAAAACAGTTTTTTAAAATTCTAACACGTGTATTTCACCAGCCTTAAAAGATTTAAAAAA
AAATCTGACAGGAAGGAAAGCGGGTGGTAAGTATCTTGGATTATTCTGCCTCATACCAGCCACTCCCAAAGTAGGAGGACCAAAGATGCC
ATGAAGACTTCTAGTTGTCTGGAAGTTATTTGGGGAAGGGGGGAAAGACACAGAGTGGGGACCTTTGGAAGTCATTTTAAAAATTTAGCT
ATGTTAATTCCACTTGTAAAGTTTGAAAGGTTTTGATTCTTGTAATTTCTGAGAATTACTATGTTTTAAATTTACTATTGGATATTTAAC
AGATCTTTCATGGGGCCAACCTATTTGCTTCCTTAATTTTCAAATTAAGTCCTAATTTGAGTCCTAAAAAAATCTTTCCTTGTTAGTTGC

>10136_10136_1_BRAF-TRIM24_BRAF_chr7_140624366_ENST00000288602_TRIM24_chr7_138258252_ENST00000343526_length(amino acids)=470AA_BP=46
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGL
AGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSIL
TSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHL
SCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIK
NPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESEDNKFSDDSDD

--------------------------------------------------------------
>10136_10136_2_BRAF-TRIM24_BRAF_chr7_140624366_ENST00000288602_TRIM24_chr7_138258252_ENST00000415680_length(transcript)=2108nt_BP=199nt
CGCCTCCCTTCCCCCTCCCCGCCCGACAGCGGCCGCTCGGGCCCCGGCTCTCGGTTATAAGATGGCGGCGCTGAGCGGTGGCGGTGGTGG
CGGCGCGGAGCCGGGCCAGGCTCTGTTCAACGGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGA
CCCTGCCATTCCGGAGGAGATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGGAAAGATACTAATATAGATCATGGCCAGCC
AAGACCACCCTCAAACAGAACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTTGCAGGACCTGTTACTATGACTAGTGTACA
CCCCCCAATACGTTCACCTAGTGCCTCCAGCGTTGGAAGCCGAGGAAGCTCTGGCTCTTCCAGCAAACCAGCAGGAGCTGACTCTACACA
CAAAGTCCCAGTGGTCATGCTGGAGCCAATTCGAATAAAACAAGAAAACAGTGGACCACCGGAAAATTATGATTTCCCTGTTGTTATAGT
GAAGCAAGAATCAGATGAAGAATCTAGGCCTCAAAATGCCAATTATCCAAGAAGCATACTCACCTCCCTGCTCTTAAATAGCAGTCAGAG
CTCTACTTCTGAGGAGACTGTGCTAAGATCAGATGCCCCTGATAGTACAGGAGATCAACCTGGACTTCACCAGGACAATTCCTCAAATGG
AAAGTCTGAATGGTTGGATCCTTCCCAGAAGTCACCTCTTCATGTTGGAGAGACAAGGAAAGAGGATGACCCCAATGAGGACTGGTGTGC
AGTTTGTCAAAACGGAGGGGAACTCCTCTGCTGTGAAAAGTGCCCCAAAGTATTCCATCTTTCTTGTCATGTGCCCACATTGACAAATTT
TCCAAGTGGAGAGTGGATTTGCACTTTCTGCCGAGACTTATCTAAACCAGAAGTTGAATATGATTGTGATGCTCCCAGTCACAACTCAGA
AAAAAAGAAAACTGAAGGCCTTGTTAAGTTAACACCTATAGATAAAAGGAAGTGTGAGCGCCTACTTTTATTTCTTTACTGCCATGAAAT
GAGCCTGGCTTTTCAAGACCCTGTTCCTCTAACTGTGCCTGATTATTACAAAATAATTAAAAATCCAATGGATTTGTCAACCATCAAGAA
AAGACTACAAGAAGATTATTCCATGTACTCAAAACCTGAAGATTTTGTAGCTGATTTTAGATTGATCTTTCAAAACTGTGCTGAATTCAA
TGAGCCTGATTCAGAAGTAGCCAATGCTGGTATAAAACTTGAAAATTATTTTGAAGAACTTCTAAAGAACCTCTATCCAGAAAAAAGGTT
TCCCAAACCAGAATTCAGGAATGAATCAGAAGATAATAAATTTAGTGATGATTCAGATGATGACTTTGTACAGCCCCGGAAGAAACGCCT
CAAAAGCATTGAAGAACGCCAGTTGCTTAAATAATATGCAGCACCACTAGCTTGTGCTGGTTTTTAGATTTTTTTGTTTTCAAAAAAACA
TTTGTCAGTAATTTAACATCACTACAAAAAGAAGAGTTTGTGACTATTCTCATCTCTGTTTTGGACGTTTACTAGACTTTGATTTCCTTA
ATAGCCCATTTCTGTTAACCTCTTATCACTAAGAAAGAAAGGAAAGAAGGAGATGAATAGAAGAAAGAAAATGGAAAGAAGGAAAAAAGG
AGGATAGAAAAAGGATGGAAGAAAGAAGCATTGAAAACAAAGACATTCTTCCCACTTCTTGGATTTTTAAACCACAGTCTGGAGTGATAG
CTACTGTAGAAAGGAAATAGACTTTGTATGAACTCTTTAAGTTGAAAAGTAAAAAATATATGTGGTTTGGATGTGTGCTTTAATTCAGCT
TTAGAAATTAATACCACTACCCGTGAATTATATGGCCTGACAATATGAATTAGGTGTACTGTACTGAAGAACAGTACTCCACAAACATGG
GTGGTAACAAGAGTTCCATCCCAGGAGGCCAAACGGTGCAACAGAAGGGTAGGTTAGATGCTATTAAGAAGGCACTTAATAGTACATCAT

>10136_10136_2_BRAF-TRIM24_BRAF_chr7_140624366_ENST00000288602_TRIM24_chr7_138258252_ENST00000415680_length(amino acids)=470AA_BP=46
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGL
AGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSIL
TSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHL
SCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIK
NPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESEDNKFSDDSDD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BRAF-TRIM24

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	TRIM24	chr7:140624366	chr7:138258252	ENST00000343526		10	19	834_840	626.0	1051.0	histone H3 that is not methylated at 'Lys-4' (H3K4me0)
Tgene	TRIM24	chr7:140624366	chr7:138258252	ENST00000415680		10	19	834_840	592.0	1017.0	histone H3 that is not methylated at 'Lys-4' (H3K4me0)

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for BRAF-TRIM24

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	BRAF	P15056	DB08881	Vemurafenib	Inhibitor	Small molecule	Approved
Hgene	BRAF	P15056	DB08881	Vemurafenib	Inhibitor	Small molecule	Approved
Hgene	BRAF	P15056	DB08881	Vemurafenib	Inhibitor	Small molecule	Approved
Hgene	BRAF	P15056	DB08896	Regorafenib	Inhibitor	Small molecule	Approved
Hgene	BRAF	P15056	DB08896	Regorafenib	Inhibitor	Small molecule	Approved
Hgene	BRAF	P15056	DB08896	Regorafenib	Inhibitor	Small molecule	Approved
Hgene	BRAF	P15056	DB14840	Ripretinib	Inhibitor	Small molecule	Approved
Hgene	BRAF	P15056	DB14840	Ripretinib	Inhibitor	Small molecule	Approved
Hgene	BRAF	P15056	DB14840	Ripretinib	Inhibitor	Small molecule	Approved
Hgene	BRAF	P15056	DB00398	Sorafenib	Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB00398	Sorafenib	Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB00398	Sorafenib	Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB08912	Dabrafenib	Antagonist\|Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB08912	Dabrafenib	Antagonist\|Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB08912	Dabrafenib	Antagonist\|Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB11718	Encorafenib	Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB11718	Encorafenib	Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB11718	Encorafenib	Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB12010	Fostamatinib	Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB12010	Fostamatinib	Inhibitor	Small molecule	Approved\|Investigational
Hgene	BRAF	P15056	DB12010	Fostamatinib	Inhibitor	Small molecule	Approved\|Investigational

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Related Diseases for BRAF-TRIM24

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BRAF	C0025202	melanoma	24	CGI;CTD_human;UNIPROT
Hgene	BRAF	C1275081	Cardio-facio-cutaneous syndrome	14	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	BRAF	C0009402	Colorectal Carcinoma	8	CTD_human;UNIPROT
Hgene	BRAF	C0028326	Noonan Syndrome	8	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	BRAF	C0238463	Papillary thyroid carcinoma	8	CTD_human;ORPHANET
Hgene	BRAF	C0040136	Thyroid Neoplasm	6	CGI;CTD_human
Hgene	BRAF	C0151468	Thyroid Gland Follicular Adenoma	6	CTD_human
Hgene	BRAF	C0175704	LEOPARD Syndrome	6	CLINGEN;GENOMICS_ENGLAND
Hgene	BRAF	C0549473	Thyroid carcinoma	6	CGI;CTD_human
Hgene	BRAF	C3150970	NOONAN SYNDROME 7	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	BRAF	C0009404	Colorectal Neoplasms	4	CTD_human
Hgene	BRAF	C3150971	LEOPARD SYNDROME 3	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	BRAF	C1519086	Pilomyxoid astrocytoma	3	ORPHANET
Hgene	BRAF	C0004565	Melanoma, B16	2	CTD_human
Hgene	BRAF	C0009075	Melanoma, Cloudman S91	2	CTD_human
Hgene	BRAF	C0018598	Melanoma, Harding-Passey	2	CTD_human
Hgene	BRAF	C0023443	Hairy Cell Leukemia	2	CGI;ORPHANET
Hgene	BRAF	C0025205	Melanoma, Experimental	2	CTD_human
Hgene	BRAF	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	BRAF	C0152013	Adenocarcinoma of lung (disorder)	2	CGI;CTD_human
Hgene	BRAF	C0376358	Malignant neoplasm of prostate	2	CTD_human
Hgene	BRAF	C0587248	Costello syndrome (disorder)	2	CLINGEN;CTD_human
Hgene	BRAF	C3501843	Nonmedullary Thyroid Carcinoma	2	CTD_human
Hgene	BRAF	C3501844	Familial Nonmedullary Thyroid Cancer	2	CTD_human
Hgene	BRAF	C0002448	Ameloblastoma	1	CTD_human
Hgene	BRAF	C0004114	Astrocytoma	1	CTD_human
Hgene	BRAF	C0010276	Craniopharyngioma	1	CTD_human;ORPHANET
Hgene	BRAF	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Hgene	BRAF	C0017638	Glioma	1	CGI;CTD_human
Hgene	BRAF	C0019621	Histiocytosis, Langerhans-Cell	1	CGI;ORPHANET
Hgene	BRAF	C0022665	Kidney Neoplasm	1	CTD_human
Hgene	BRAF	C0023903	Liver neoplasms	1	CTD_human
Hgene	BRAF	C0024232	Lymphatic Metastasis	1	CTD_human
Hgene	BRAF	C0024694	Mandibular Neoplasms	1	CTD_human
Hgene	BRAF	C0027659	Neoplasms, Experimental	1	CTD_human
Hgene	BRAF	C0027962	Melanocytic nevus	1	GENOMICS_ENGLAND
Hgene	BRAF	C0036920	Sezary Syndrome	1	CTD_human
Hgene	BRAF	C0041409	Turner Syndrome, Male	1	CTD_human
Hgene	BRAF	C0079773	Lymphoma, T-Cell, Cutaneous	1	CTD_human
Hgene	BRAF	C0205768	Subependymal Giant Cell Astrocytoma	1	CTD_human
Hgene	BRAF	C0206686	Adrenocortical carcinoma	1	CTD_human
Hgene	BRAF	C0206754	Neuroendocrine Tumors	1	CTD_human
Hgene	BRAF	C0259783	mixed gliomas	1	CTD_human
Hgene	BRAF	C0278875	Adult Craniopharyngioma	1	CTD_human
Hgene	BRAF	C0280783	Juvenile Pilocytic Astrocytoma	1	CTD_human
Hgene	BRAF	C0280785	Diffuse Astrocytoma	1	CTD_human
Hgene	BRAF	C0334579	Anaplastic astrocytoma	1	CGI;CTD_human
Hgene	BRAF	C0334580	Protoplasmic astrocytoma	1	CTD_human
Hgene	BRAF	C0334581	Gemistocytic astrocytoma	1	CTD_human
Hgene	BRAF	C0334582	Fibrillary Astrocytoma	1	CTD_human
Hgene	BRAF	C0334583	Pilocytic Astrocytoma	1	CGI;CTD_human
Hgene	BRAF	C0338070	Childhood Cerebral Astrocytoma	1	CTD_human
Hgene	BRAF	C0345904	Malignant neoplasm of liver	1	CTD_human
Hgene	BRAF	C0376407	Granulomatous Slack Skin	1	CTD_human
Hgene	BRAF	C0406803	Syringocystadenoma Papilliferum	1	GENOMICS_ENGLAND
Hgene	BRAF	C0431128	Papillary craniopharyngioma	1	CTD_human
Hgene	BRAF	C0431129	Adamantinous Craniopharyngioma	1	CTD_human
Hgene	BRAF	C0547065	Mixed oligoastrocytoma	1	CTD_human
Hgene	BRAF	C0555198	Malignant Glioma	1	CTD_human
Hgene	BRAF	C0596263	Carcinogenesis	1	CTD_human
Hgene	BRAF	C0684249	Carcinoma of lung	1	CGI;UNIPROT
Hgene	BRAF	C0740457	Malignant neoplasm of kidney	1	CTD_human
Hgene	BRAF	C0750935	Cerebral Astrocytoma	1	CTD_human
Hgene	BRAF	C0750936	Intracranial Astrocytoma	1	CTD_human
Hgene	BRAF	C0751061	Craniopharyngioma, Child	1	CTD_human
Hgene	BRAF	C0920269	Microsatellite Instability	1	CTD_human
Hgene	BRAF	C1527404	Female Pseudo-Turner Syndrome	1	CTD_human
Hgene	BRAF	C1704230	Grade I Astrocytoma	1	CTD_human
Hgene	BRAF	C1721098	Replication Error Phenotype	1	CTD_human
Hgene	BRAF	C2239176	Liver carcinoma	1	CTD_human
Hgene	BRAF	C4551484	Leopard Syndrome 1	1	GENOMICS_ENGLAND
Hgene	BRAF	C4551602	Noonan Syndrome 1	1	CTD_human
Hgene	BRAF	C4721532	Lymphoma, Non-Hodgkin, Familial	1	UNIPROT
Hgene	BRAF	C4733333	familial non-medullary thyroid cancer	1	GENOMICS_ENGLAND
Tgene		C0238463	Papillary thyroid carcinoma	2	ORPHANET
Tgene		C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene		C2239176	Liver carcinoma	1	CTD_human
Tgene		C3658266	Prostatic Cancer, Castration-Resistant	1	CTD_human
Tgene		C3658267	Prostatic Neoplasms, Castration-Resistant	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:BRAF-TRIM24 (FusionGDB2 ID:HG673TG8805)

Fusion Gene Summary for BRAF-TRIM24

Fusion Gene ORF analysis for BRAF-TRIM24

Fusion Genomic Features for BRAF-TRIM24

Fusion Protein Features for BRAF-TRIM24

Fusion Gene Sequence for BRAF-TRIM24

Fusion Gene PPI Analysis for BRAF-TRIM24

Related Drugs for BRAF-TRIM24

Related Diseases for BRAF-TRIM24

Fusion Gene Studies
in Kim Lab