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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ADAM17-SEC31A (FusionGDB2 ID:HG6868TG22872) |
Fusion Gene Summary for ADAM17-SEC31A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADAM17-SEC31A | Fusion gene ID: hg6868tg22872 | Hgene | Tgene | Gene symbol | ADAM17 | SEC31A | Gene ID | 6868 | 22872 |
| Gene name | ADAM metallopeptidase domain 17 | SEC31 homolog A, COPII coat complex component | |
| Synonyms | ADAM18|CD156B|CSVP|NISBD|NISBD1|TACE | ABP125|ABP130|HSPC275|HSPC334|NEDSOSB|SEC31L1 | |
| Cytomap | ('ADAM17')('SEC31A') 2p25.1 | 4q21.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | disintegrin and metalloproteinase domain-containing protein 17ADAM metallopeptidase domain 18TNF-alpha convertaseTNF-alpha converting enzymesnake venom-like proteasetumor necrosis factor, alpha, converting enzyme | protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | . | O94979 | |
| Ensembl transtripts involved in fusion gene | ENST00000310823, ENST00000497134, | ||
| Fusion gene scores | * DoF score | 6 X 8 X 6=288 | 27 X 19 X 11=5643 |
| # samples | 11 | 28 | |
| ** MAII score | log2(11/288*10)=-1.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/5643*10)=-4.33296361729939 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADAM17 [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ADAM17(9634765)-SEC31A(83765662), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ADAM17-SEC31A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM17-SEC31A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM17-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM17-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADAM17 | GO:0001666 | response to hypoxia | 18276953 |
| Hgene | ADAM17 | GO:0006508 | proteolysis | 24227843 |
| Hgene | ADAM17 | GO:0006509 | membrane protein ectodomain proteolysis | 9034190|9574564|17786981|18676862 |
| Hgene | ADAM17 | GO:0007155 | cell adhesion | 14970227 |
| Hgene | ADAM17 | GO:0007173 | epidermal growth factor receptor signaling pathway | 12743035 |
| Hgene | ADAM17 | GO:0007220 | Notch receptor processing | 24226769 |
| Hgene | ADAM17 | GO:0032496 | response to lipopolysaccharide | 18383040 |
| Hgene | ADAM17 | GO:0033627 | cell adhesion mediated by integrin | 14970227 |
| Hgene | ADAM17 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 24813629 |
| Hgene | ADAM17 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 18483258 |
| Hgene | ADAM17 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis | 14625290|15691827|17010968 |
| Hgene | ADAM17 | GO:0071403 | cellular response to high density lipoprotein particle stimulus | 17786981 |
| Hgene | ADAM17 | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 24813629 |
| Tgene | SEC31A | GO:0051592 | response to calcium ion | 17196169 |
| Tgene | SEC31A | GO:0090110 | cargo loading into COPII-coated vesicle | 17499046|18843296 |
| Fusion gene breakpoints across ADAM17 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SEC31A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-VR-A8EU | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
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Fusion Gene ORF analysis for ADAM17-SEC31A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000310823 | ENST00000436790 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000264405 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000311785 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000326950 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000348405 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000355196 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000395310 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000432794 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000443462 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000448323 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000500777 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000505472 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000505984 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000508479 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000508502 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000509142 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| In-frame | ENST00000310823 | ENST00000513858 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000264405 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000311785 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000326950 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000348405 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000355196 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000395310 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000432794 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000443462 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000448323 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000500777 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000505472 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000505984 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000508479 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000508502 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000509142 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-3CDS | ENST00000497134 | ENST00000513858 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| intron-intron | ENST00000497134 | ENST00000436790 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000348405 | SEC31A | chr4 | 83765662 | - | 3671 | 2097 | 183 | 3257 | 1024 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000513858 | SEC31A | chr4 | 83765662 | - | 3329 | 2097 | 183 | 2915 | 910 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000395310 | SEC31A | chr4 | 83765662 | - | 3671 | 2097 | 183 | 3257 | 1024 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000443462 | SEC31A | chr4 | 83765662 | - | 3625 | 2097 | 183 | 3212 | 1009 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000509142 | SEC31A | chr4 | 83765662 | - | 3328 | 2097 | 183 | 2915 | 910 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000326950 | SEC31A | chr4 | 83765662 | - | 3670 | 2097 | 183 | 3257 | 1024 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000432794 | SEC31A | chr4 | 83765662 | - | 3709 | 2097 | 183 | 3296 | 1037 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000311785 | SEC31A | chr4 | 83765662 | - | 3328 | 2097 | 183 | 2915 | 910 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000448323 | SEC31A | chr4 | 83765662 | - | 3670 | 2097 | 183 | 3257 | 1024 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000505472 | SEC31A | chr4 | 83765662 | - | 3660 | 2097 | 183 | 3257 | 1024 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000500777 | SEC31A | chr4 | 83765662 | - | 3318 | 2097 | 183 | 2915 | 910 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000508502 | SEC31A | chr4 | 83765662 | - | 3276 | 2097 | 183 | 3212 | 1009 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000355196 | SEC31A | chr4 | 83765662 | - | 3321 | 2097 | 183 | 3257 | 1024 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000264405 | SEC31A | chr4 | 83765662 | - | 3265 | 2097 | 183 | 3212 | 1009 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000505984 | SEC31A | chr4 | 83765662 | - | 3243 | 2097 | 183 | 3212 | 1009 |
| ENST00000310823 | ADAM17 | chr2 | 9634765 | - | ENST00000508479 | SEC31A | chr4 | 83765662 | - | 2922 | 2097 | 183 | 2228 | 681 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000310823 | ENST00000348405 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000383799 | 0.99961615 |
| ENST00000310823 | ENST00000513858 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000455655 | 0.9995443 |
| ENST00000310823 | ENST00000395310 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000383799 | 0.99961615 |
| ENST00000310823 | ENST00000443462 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000397012 | 0.999603 |
| ENST00000310823 | ENST00000509142 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000456808 | 0.9995432 |
| ENST00000310823 | ENST00000326950 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000383947 | 0.999616 |
| ENST00000310823 | ENST00000432794 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000457206 | 0.99954283 |
| ENST00000310823 | ENST00000311785 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000456808 | 0.9995432 |
| ENST00000310823 | ENST00000448323 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000383947 | 0.999616 |
| ENST00000310823 | ENST00000505472 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000403834 | 0.9995962 |
| ENST00000310823 | ENST00000500777 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000481811 | 0.99951816 |
| ENST00000310823 | ENST00000508502 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000461902 | 0.99953806 |
| ENST00000310823 | ENST00000355196 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000444152 | 0.9995559 |
| ENST00000310823 | ENST00000264405 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000509304 | 0.9994906 |
| ENST00000310823 | ENST00000505984 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000517299 | 0.99948263 |
| ENST00000310823 | ENST00000508479 | ADAM17 | chr2 | 9634765 | - | SEC31A | chr4 | 83765662 | - | 0.000411418 | 0.99958855 |
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Fusion Genomic Features for ADAM17-SEC31A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ADAM17-SEC31A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:9634765/chr4:83765662) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | SEC31A |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 564_602 | 638 | 825.0 | Compositional bias | Note=Cys-rich |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 96_99 | 638 | 825.0 | Compositional bias | Note=Poly-Val |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 223_474 | 638 | 825.0 | Domain | Peptidase M12B |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 475_563 | 638 | 825.0 | Domain | Disintegrin |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 182_189 | 638 | 825.0 | Motif | Cysteine switch |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 800_1091 | 795 | 1182.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 800_1091 | 795 | 1182.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 800_1091 | 795 | 1068.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 800_1091 | 795 | 1068.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 842_848 | 834 | 1107.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 842_848 | 795 | 1182.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 842_848 | 795 | 1182.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 842_848 | 834 | 1221.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 842_848 | 834 | 1221.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 842_848 | 834 | 1234.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 842_848 | 829 | 1201.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 842_848 | 834 | 1221.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 842_848 | 795 | 1068.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 842_848 | 834 | 1206.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 842_848 | 834 | 1107.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 842_848 | 795 | 1068.0 | Motif | Note=ALG-2-binding site motif-2 (ABS-2)%2C |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 731_738 | 638 | 825.0 | Motif | SH3-binding |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 741_748 | 638 | 825.0 | Motif | SH3-binding |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 603_671 | 638 | 825.0 | Region | Note=Crambin-like |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 215_671 | 638 | 825.0 | Topological domain | Extracellular |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 693_824 | 638 | 825.0 | Topological domain | Cytoplasmic |
| Hgene | ADAM17 | chr2:9634765 | chr4:83765662 | ENST00000310823 | - | 15 | 19 | 672_692 | 638 | 825.0 | Transmembrane | Helical |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 800_1091 | 834 | 1107.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 800_1091 | 834 | 1221.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 800_1091 | 834 | 1221.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 800_1091 | 834 | 1234.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 800_1091 | 829 | 1201.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 800_1091 | 834 | 1221.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 800_1091 | 834 | 1206.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 800_1091 | 834 | 1107.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 120_160 | 834 | 1107.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 166_206 | 834 | 1107.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 209_254 | 834 | 1107.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 258_298 | 834 | 1107.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 301_342 | 834 | 1107.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 4_47 | 834 | 1107.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 68_111 | 834 | 1107.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 120_160 | 795 | 1182.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 166_206 | 795 | 1182.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 209_254 | 795 | 1182.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 258_298 | 795 | 1182.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 301_342 | 795 | 1182.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 4_47 | 795 | 1182.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 68_111 | 795 | 1182.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 120_160 | 795 | 1182.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 166_206 | 795 | 1182.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 209_254 | 795 | 1182.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 258_298 | 795 | 1182.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 301_342 | 795 | 1182.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 4_47 | 795 | 1182.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 68_111 | 795 | 1182.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 120_160 | 834 | 1221.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 166_206 | 834 | 1221.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 209_254 | 834 | 1221.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 258_298 | 834 | 1221.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 301_342 | 834 | 1221.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 4_47 | 834 | 1221.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 68_111 | 834 | 1221.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 120_160 | 834 | 1221.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 166_206 | 834 | 1221.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 209_254 | 834 | 1221.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 258_298 | 834 | 1221.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 301_342 | 834 | 1221.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 4_47 | 834 | 1221.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 68_111 | 834 | 1221.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 120_160 | 834 | 1234.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 166_206 | 834 | 1234.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 209_254 | 834 | 1234.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 258_298 | 834 | 1234.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 301_342 | 834 | 1234.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 4_47 | 834 | 1234.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 68_111 | 834 | 1234.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 120_160 | 829 | 1201.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 166_206 | 829 | 1201.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 209_254 | 829 | 1201.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 258_298 | 829 | 1201.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 301_342 | 829 | 1201.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 4_47 | 829 | 1201.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 68_111 | 829 | 1201.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 120_160 | 834 | 1221.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 166_206 | 834 | 1221.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 209_254 | 834 | 1221.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 258_298 | 834 | 1221.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 301_342 | 834 | 1221.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 4_47 | 834 | 1221.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 68_111 | 834 | 1221.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 120_160 | 795 | 1068.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 166_206 | 795 | 1068.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 209_254 | 795 | 1068.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 258_298 | 795 | 1068.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 301_342 | 795 | 1068.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 4_47 | 795 | 1068.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 68_111 | 795 | 1068.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 120_160 | 834 | 1206.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 166_206 | 834 | 1206.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 209_254 | 834 | 1206.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 258_298 | 834 | 1206.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 301_342 | 834 | 1206.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 4_47 | 834 | 1206.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 68_111 | 834 | 1206.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 120_160 | 834 | 1107.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 166_206 | 834 | 1107.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 209_254 | 834 | 1107.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 258_298 | 834 | 1107.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 301_342 | 834 | 1107.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 4_47 | 834 | 1107.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 68_111 | 834 | 1107.0 | Repeat | Note=WD 2 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 120_160 | 795 | 1068.0 | Repeat | Note=WD 3 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 166_206 | 795 | 1068.0 | Repeat | Note=WD 4 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 209_254 | 795 | 1068.0 | Repeat | Note=WD 5 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 258_298 | 795 | 1068.0 | Repeat | Note=WD 6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 301_342 | 795 | 1068.0 | Repeat | Note=WD 7 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 4_47 | 795 | 1068.0 | Repeat | Note=WD 1 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 68_111 | 795 | 1068.0 | Repeat | Note=WD 2 |
Top |
Fusion Gene Sequence for ADAM17-SEC31A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >1981_1981_1_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000264405_length(transcript)=3265nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT CCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATC ACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCT TCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCA AAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAA CCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAG AGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTA CACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAG ACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATAT >1981_1981_1_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000264405_length(amino acids)=1009AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET -------------------------------------------------------------- >1981_1981_2_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000311785_length(transcript)=3328nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTCCTCAGAATGGTTGGAATGACCCTCCA GCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGT GACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGT GGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGG GCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTA AAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGT TTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACT CGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAA GTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAA AAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATAC TCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTA TTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATC >1981_1981_2_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000311785_length(amino acids)=910AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV -------------------------------------------------------------- >1981_1981_3_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000326950_length(transcript)=3670nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG >1981_1981_3_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000326950_length(amino acids)=1024AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL -------------------------------------------------------------- >1981_1981_4_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000348405_length(transcript)=3671nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG >1981_1981_4_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000348405_length(amino acids)=1024AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL -------------------------------------------------------------- >1981_1981_5_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000355196_length(transcript)=3321nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC >1981_1981_5_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000355196_length(amino acids)=1024AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL -------------------------------------------------------------- >1981_1981_6_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000395310_length(transcript)=3671nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG >1981_1981_6_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000395310_length(amino acids)=1024AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL -------------------------------------------------------------- >1981_1981_7_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000432794_length(transcript)=3709nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGAAAACCAGTCTATCCAAGACCAGGCACCTATGTTGGAAGGTCCTCAG AATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCA CCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTC CCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCC AATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATT CCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAG CTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAAC ATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCT GCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCAT TTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTT ACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTT TCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATAT ACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAGAGCTAAAACTAAATTTCTTTCATGTCCTCCCTACTTCCTCAGTGTCAATCA >1981_1981_7_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000432794_length(amino acids)=1037AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTENQSIQDQAPMLEGPQN GWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPN IEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNI -------------------------------------------------------------- >1981_1981_8_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000443462_length(transcript)=3625nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT CCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATC ACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCT TCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCA AAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAA CCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAG AGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTA CACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAG ACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATAT TGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGA GCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGA TGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCT CAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAGAGCTAAAACTAAATTTCTTTCATGTCCTCCCTACTTCCTCAGTGT >1981_1981_8_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000443462_length(amino acids)=1009AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET -------------------------------------------------------------- >1981_1981_9_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000448323_length(transcript)=3670nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG >1981_1981_9_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000448323_length(amino acids)=1024AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL -------------------------------------------------------------- >1981_1981_10_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000500777_length(transcript)=3318nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTCCTCAGAATGGTTGGAATGACCCTCCA GCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGT GACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGT GGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGG GCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTA AAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGT TTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACT CGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAA GTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAA AAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATAC TCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTA TTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATC >1981_1981_10_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000500777_length(amino acids)=910AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV -------------------------------------------------------------- >1981_1981_11_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000505472_length(transcript)=3660nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG >1981_1981_11_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000505472_length(amino acids)=1024AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL -------------------------------------------------------------- >1981_1981_12_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000505984_length(transcript)=3243nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT CCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATC ACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCT TCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCA AAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAA CCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAG AGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTA CACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAG ACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATAT >1981_1981_12_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000505984_length(amino acids)=1009AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET -------------------------------------------------------------- >1981_1981_13_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000508479_length(transcript)=2922nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTAAGTAGTGTGACCCCAAAGTCCTTTCA GAGCAGTATTTATGATCTAATTTAGTAACTTTACTTTGAAGCCCCAAAGTCATTGTCAAATCAATAAGTAAGAACCATTGTGCATAGGAT TCCTGAGTCCCTGCTACAAAGAGACATGTTTTTTTAGGAGGTGGCCTGAATCACTATGCTAGGAAGTAGCTCCTTTGTCACACTGTTCAG AGTAGTTGACTCCTGTTCCTCAGCCATTACTAAGACTTGTTAAAGATAATCAAGTGTCCCATGATTTTGGTATAAAGAAACAGAATTTTA GAAATTATTTTTTACATATTCTTTTTCTTCAGGCAAGATGACACAAATTATTTTTGGAAAAATGGTTTCAAGGGGCATTTGTTATTACTG TTTTTCCATTTTATTTATTTATTTAATAGACTTTGTATTTTAGAGCAGTCTTAGGTTCAGAACAAAATTGAGCAGAAAGTACAGAGTGCC CCCACTATTGACATCCTACGCCACAGTGGTGTATTTGTTACAATCGATGAACCTACATCAATGTCTCATTATCACCCAAAGTCCACAGTT TACACTCTCAGTGTTGTACATTCTGTGGATTTTAACAAATGTGTAATGACATGTATCTATTAGTGGCATTTTTAAAAGAAAATAATTATA >1981_1981_13_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000508479_length(amino acids)=681AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC -------------------------------------------------------------- >1981_1981_14_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000508502_length(transcript)=3276nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT CCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATC ACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCT TCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCA AAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAA CCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAG AGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTA CACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAG ACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATAT >1981_1981_14_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000508502_length(amino acids)=1009AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET -------------------------------------------------------------- >1981_1981_15_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000509142_length(transcript)=3328nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTCCTCAGAATGGTTGGAATGACCCTCCA GCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGT GACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGT GGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGG GCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTA AAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGT TTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACT CGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAA GTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAA AAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATAC TCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTA TTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATC >1981_1981_15_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000509142_length(amino acids)=910AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV -------------------------------------------------------------- >1981_1981_16_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000513858_length(transcript)=3329nt_BP=2097nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTCCTCAGAATGGTTGGAATGACCCTCCA GCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGT GACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGT GGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGG GCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTA AAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGT TTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACT CGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAA GTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAA AAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATAC TCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTA TTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATC >1981_1981_16_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000513858_length(amino acids)=910AA_BP=638 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ADAM17-SEC31A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 800_1113 | 795.0 | 1182.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 800_1113 | 795.0 | 1182.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 800_1113 | 795.0 | 1068.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 800_1113 | 795.0 | 1068.0 | PDCD6 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 800_1113 | 834.0 | 1107.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 800_1113 | 834.0 | 1221.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 800_1113 | 834.0 | 1221.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 800_1113 | 834.0 | 1234.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 800_1113 | 829.0 | 1201.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 800_1113 | 834.0 | 1221.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 800_1113 | 834.0 | 1206.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 800_1113 | 834.0 | 1107.0 | PDCD6 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000311785 | 19 | 26 | 161_471 | 834.0 | 1107.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000326950 | 17 | 25 | 161_471 | 795.0 | 1182.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000348405 | 17 | 25 | 161_471 | 795.0 | 1182.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000355196 | 21 | 29 | 161_471 | 834.0 | 1221.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000395310 | 19 | 27 | 161_471 | 834.0 | 1221.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000432794 | 19 | 28 | 161_471 | 834.0 | 1234.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000443462 | 18 | 26 | 161_471 | 829.0 | 1201.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000448323 | 19 | 27 | 161_471 | 834.0 | 1221.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000500777 | 16 | 23 | 161_471 | 795.0 | 1068.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000508502 | 19 | 27 | 161_471 | 834.0 | 1206.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000509142 | 19 | 26 | 161_471 | 834.0 | 1107.0 | SEC13 | |
| Tgene | SEC31A | chr2:9634765 | chr4:83765662 | ENST00000513858 | 17 | 24 | 161_471 | 795.0 | 1068.0 | SEC13 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADAM17-SEC31A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ADAM17-SEC31A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADAM17 | C3280501 | INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 1 | 2 | CTD_human;GENOMICS_ENGLAND |
| Hgene | ADAM17 | C0005758 | Bulla | 1 | CTD_human |
| Hgene | ADAM17 | C0009319 | Colitis | 1 | CTD_human |
| Hgene | ADAM17 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ADAM17 | C3860213 | Autoinflammatory disorder | 1 | GENOMICS_ENGLAND |
| Hgene | ADAM17 | C4751120 | Neonatal inflammatory skin and bowel disease | 1 | ORPHANET |
| Tgene | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
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