Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ADAM17-ITGB1BP1 (FusionGDB2 ID:HG6868TG9270)

Fusion Gene Summary for ADAM17-ITGB1BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM17-ITGB1BP1
Fusion gene ID: hg6868tg9270
HgeneTgene
Gene symbol

ADAM17

ITGB1BP1

Gene ID

6868

9270

Gene nameADAM metallopeptidase domain 17integrin subunit beta 1 binding protein 1
SynonymsADAM18|CD156B|CSVP|NISBD|NISBD1|TACEICAP-1A|ICAP-1B|ICAP-1alpha|ICAP1|ICAP1A|ICAP1B
Cytomap('ADAM17')('ITGB1BP1')

2p25.1

2p25.1

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 17ADAM metallopeptidase domain 18TNF-alpha convertaseTNF-alpha converting enzymesnake venom-like proteasetumor necrosis factor, alpha, converting enzymeintegrin beta-1-binding protein 1bodeninintegrin cytoplasmic domain-associated protein 1integrin cytoplasmic domain-associated protein 1-alphaintegrin cytoplasmic domain-associated protein 1-beta
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310823, ENST00000497134, 
Fusion gene scores* DoF score6 X 8 X 6=2884 X 4 X 3=48
# samples 115
** MAII scorelog2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADAM17 [Title/Abstract] AND ITGB1BP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAM17(9695638)-ITGB1BP1(9558861), # samples:2
Anticipated loss of major functional domain due to fusion event.ADAM17-ITGB1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM17-ITGB1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM17-ITGB1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM17-ITGB1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM17

GO:0001666

response to hypoxia

18276953

HgeneADAM17

GO:0006508

proteolysis

24227843

HgeneADAM17

GO:0006509

membrane protein ectodomain proteolysis

9034190|9574564|17786981|18676862

HgeneADAM17

GO:0007155

cell adhesion

14970227

HgeneADAM17

GO:0007173

epidermal growth factor receptor signaling pathway

12743035

HgeneADAM17

GO:0007220

Notch receptor processing

24226769

HgeneADAM17

GO:0032496

response to lipopolysaccharide

18383040

HgeneADAM17

GO:0033627

cell adhesion mediated by integrin

14970227

HgeneADAM17

GO:0043536

positive regulation of blood vessel endothelial cell migration

24813629

HgeneADAM17

GO:0045741

positive regulation of epidermal growth factor-activated receptor activity

18483258

HgeneADAM17

GO:0051088

PMA-inducible membrane protein ectodomain proteolysis

14625290|15691827|17010968

HgeneADAM17

GO:0071403

cellular response to high density lipoprotein particle stimulus

17786981

HgeneADAM17

GO:1905564

positive regulation of vascular endothelial cell proliferation

24813629

TgeneITGB1BP1

GO:0002043

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

20616313

TgeneITGB1BP1

GO:0006469

negative regulation of protein kinase activity

20616313

TgeneITGB1BP1

GO:0007160

cell-matrix adhesion

9281591

TgeneITGB1BP1

GO:0007229

integrin-mediated signaling pathway

11919189|15703214

TgeneITGB1BP1

GO:0008284

positive regulation of cell proliferation

15703214

TgeneITGB1BP1

GO:0008285

negative regulation of cell proliferation

20616313

TgeneITGB1BP1

GO:0010595

positive regulation of endothelial cell migration

20616313

TgeneITGB1BP1

GO:0032091

negative regulation of protein binding

12473654

TgeneITGB1BP1

GO:0032148

activation of protein kinase B activity

20616313

TgeneITGB1BP1

GO:0035148

tube formation

20616313

TgeneITGB1BP1

GO:0035924

cellular response to vascular endothelial growth factor stimulus

20616313

TgeneITGB1BP1

GO:0043087

regulation of GTPase activity

11807099

TgeneITGB1BP1

GO:0044344

cellular response to fibroblast growth factor stimulus

20616313

TgeneITGB1BP1

GO:0045747

positive regulation of Notch signaling pathway

20616313

TgeneITGB1BP1

GO:0045944

positive regulation of transcription by RNA polymerase II

15703214|20616313

TgeneITGB1BP1

GO:0051895

negative regulation of focal adhesion assembly

12473654

TgeneITGB1BP1

GO:0051897

positive regulation of protein kinase B signaling

20616313

TgeneITGB1BP1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

20616313

TgeneITGB1BP1

GO:0072659

protein localization to plasma membrane

17916086

TgeneITGB1BP1

GO:0090051

negative regulation of cell migration involved in sprouting angiogenesis

20616313

TgeneITGB1BP1

GO:0090315

negative regulation of protein targeting to membrane

11807099

TgeneITGB1BP1

GO:0097746

regulation of blood vessel diameter

20616313

TgeneITGB1BP1

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

11807099


check buttonFusion gene breakpoints across ADAM17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ITGB1BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-7389-01AADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
ChimerDB4HNSCTCGA-CR-7389ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
ChimerDB4STADTCGA-CD-5813ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-


Top

Fusion Gene ORF analysis for ADAM17-ITGB1BP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000310823ENST00000238091ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000310823ENST00000355346ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000310823ENST00000359712ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000310823ENST00000359712ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
5CDS-5UTRENST00000310823ENST00000360635ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000310823ENST00000456913ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000310823ENST00000456913ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
5CDS-5UTRENST00000310823ENST00000488451ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000310823ENST00000488451ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
5CDS-5UTRENST00000310823ENST00000490426ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
5CDS-5UTRENST00000497134ENST00000238091ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000497134ENST00000355346ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000497134ENST00000359712ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000497134ENST00000359712ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
5CDS-5UTRENST00000497134ENST00000360635ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000497134ENST00000456913ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000497134ENST00000456913ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
5CDS-5UTRENST00000497134ENST00000488451ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-5UTRENST00000497134ENST00000488451ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
5CDS-5UTRENST00000497134ENST00000490426ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
5CDS-intronENST00000310823ENST00000490426ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
5CDS-intronENST00000497134ENST00000490426ADAM17chr2

9695638

-ITGB1BP1chr2

9558861

-
In-frameENST00000310823ENST00000238091ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
In-frameENST00000310823ENST00000355346ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
In-frameENST00000310823ENST00000360635ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
In-frameENST00000497134ENST00000238091ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
In-frameENST00000497134ENST00000355346ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-
In-frameENST00000497134ENST00000360635ADAM17chr2

9675962

-ITGB1BP1chr2

9548334

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310823ADAM17chr29675962-ENST00000360635ITGB1BP1chr29548334-4307633183947254
ENST00000310823ADAM17chr29675962-ENST00000238091ITGB1BP1chr29548334-1948633183797204
ENST00000310823ADAM17chr29675962-ENST00000355346ITGB1BP1chr29548334-2098633183947254
ENST00000497134ADAM17chr29675962-ENST00000360635ITGB1BP1chr29548334-4311637187951254
ENST00000497134ADAM17chr29675962-ENST00000238091ITGB1BP1chr29548334-1952637187801204
ENST00000497134ADAM17chr29675962-ENST00000355346ITGB1BP1chr29548334-2102637187951254

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310823ENST00000360635ADAM17chr29675962-ITGB1BP1chr29548334-0.000507110.9994929
ENST00000310823ENST00000238091ADAM17chr29675962-ITGB1BP1chr29548334-0.0026391420.9973609
ENST00000310823ENST00000355346ADAM17chr29675962-ITGB1BP1chr29548334-0.0020941490.99790585
ENST00000497134ENST00000360635ADAM17chr29675962-ITGB1BP1chr29548334-0.0005070270.999493
ENST00000497134ENST00000238091ADAM17chr29675962-ITGB1BP1chr29548334-0.0022786360.9977214
ENST00000497134ENST00000355346ADAM17chr29675962-ITGB1BP1chr29548334-0.0017382990.99826175

Top

Fusion Genomic Features for ADAM17-ITGB1BP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ADAM17-ITGB1BP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:9695638/chr2:9558861)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-41996_99150825.0Compositional biasNote=Poly-Val

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419564_602150825.0Compositional biasNote=Cys-rich
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419223_474150825.0DomainPeptidase M12B
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419475_563150825.0DomainDisintegrin
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419182_189150825.0MotifCysteine switch
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419731_738150825.0MotifSH3-binding
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419741_748150825.0MotifSH3-binding
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419603_671150825.0RegionNote=Crambin-like
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419215_671150825.0Topological domainExtracellular
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419693_824150825.0Topological domainCytoplasmic
HgeneADAM17chr2:9675962chr2:9548334ENST00000310823-419672_692150825.0TransmembraneHelical
TgeneITGB1BP1chr2:9675962chr2:9548334ENST000002380913610_5796151.0Compositional biasNote=Ser/Thr-rich
TgeneITGB1BP1chr2:9675962chr2:9548334ENST000003553463710_5796201.0Compositional biasNote=Ser/Thr-rich
TgeneITGB1BP1chr2:9675962chr2:9548334ENST000003606354810_5796201.0Compositional biasNote=Ser/Thr-rich
TgeneITGB1BP1chr2:9675962chr2:9548334ENST000004884514710_5796151.0Compositional biasNote=Ser/Thr-rich
TgeneITGB1BP1chr2:9675962chr2:9548334ENST000002380913658_20096151.0DomainNote=PID
TgeneITGB1BP1chr2:9675962chr2:9548334ENST000003553463758_20096201.0DomainNote=PID
TgeneITGB1BP1chr2:9675962chr2:9548334ENST000003606354858_20096201.0DomainNote=PID
TgeneITGB1BP1chr2:9675962chr2:9548334ENST000004884514758_20096151.0DomainNote=PID


Top

Fusion Gene Sequence for ADAM17-ITGB1BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1977_1977_1_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000238091_length(transcript)=1948nt_BP=633nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATCAGAT
CAATATGAACAAGCACAAGCCATTTGCAAGGTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCA
AGTAGAAGTCAACTTCATCTGAAAGTTCAGCTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAG
ATTTTCTGAAGAAAATGGATTGTGTAAAATGCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGT
CATCTATTTTCTGGGCTAAAAAACTTCATTTGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGA
GGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCT
GAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGT
GACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAG
ATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACA
CTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGG
TCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAA
GACTGAGGACATGGGCTCAGTGGTGGCTTCCCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGG
ATTCATGCTGGTCTGGAACAGTGACATTGCCAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCA
ACCACAATTCCTAGAGTTAAGAGAACCTTAAAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACT

>1977_1977_1_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000238091_length(amino acids)=204AA_BP=0
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ

--------------------------------------------------------------
>1977_1977_2_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000355346_length(transcript)=2098nt_BP=633nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATCAGAT
CAATATGATGTTTTGCACAGGCATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGGGCGGGAAAAAGCTTACTG
GCTCTGAAGACCACAGATGCAAGCAATGAGGAATACAGCCTGTGGGTTTATCAGTGCAACAGCCTGGAACAAGCACAAGCCATTTGCAAG
GTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCAAGTAGAAGTCAACTTCATCTGAAAGTTCAG
CTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAGATTTTCTGAAGAAAATGGATTGTGTAAAAT
GCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGTCATCTATTTTCTGGGCTAAAAAACTTCATT
TGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAG
GCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACT
CAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGA
CTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACA
CACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACA
GAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGC
CTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAAGACTGAGGACATGGGCTCAGTGGTGGCTTC
CCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGGATTCATGCTGGTCTGGAACAGTGACATTGC
CAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCAACCACAATTCCTAGAGTTAAGAGAACCTTA
AAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACTTTTTTTAAAGGACTGTCAATATACAAAACT

>1977_1977_2_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000355346_length(amino acids)=254AA_BP=0
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ

--------------------------------------------------------------
>1977_1977_3_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000360635_length(transcript)=4307nt_BP=633nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATCAGAT
CAATATGATGTTTTGCACAGGCATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGGGCGGGAAAAAGCTTACTG
GCTCTGAAGACCACAGATGCAAGCAATGAGGAATACAGCCTGTGGGTTTATCAGTGCAACAGCCTGGAACAAGCACAAGCCATTTGCAAG
GTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCAAGTAGAAGTCAACTTCATCTGAAAGTTCAG
CTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAGATTTTCTGAAGAAAATGGATTGTGTAAAAT
GCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGTCATCTATTTTCTGGGCTAAAAAACTTCATT
TGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAG
GCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACT
CAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGA
CTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACA
CACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACA
GAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGC
CTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAAGACTGAGGACATGGGCTCAGTGGTGGCTTC
CCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGGATTCATGCTGGTCTGGAACAGTGACATTGC
CAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCAACCACAATTCCTAGAGTTAAGAGAACCTTA
AAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACTTTTTTTAAAGGACTGTCAATATACAAAACT
TTAAAGATTAAAAACATTAAAAATAAAACCATGTCCATTTAAAAGTATTTTATTTTTTTCCAGTCAAATGACTAGTTAACAAGAAGAGTA
AACTTATTAAACATGCTCTAATTATAAATCACTGCATTAAGGACAATGAAAATAATCAATTTCGGTTATACAATATATACAGTTGTGCTG
CAACCAAAGTAATCAGGTGAATGAACTGAATATCATACATCTCAAAATAGCATCCTAAGCTGCATATTATGTTATCCACCCCTTAACAGA
TCACACAGTTACTCTTAGTCTGTGTACATGTTCTGAGCCATCATCCCAGATCTGATGGAGAATGGCATGCAAAATGCCAGAATCCTGCAG
CTGCAGTTCATGAAACATAAACTTTAAATATAAATAGATATCTACAATGTTTTTCTTTCTCTTAGTTGCTTTTTTAATTTGCAAGGAGCA
AATAACTAAGAAAGGATATTAGCAGGGTCGTTAATATAATTTCTCCTCTGGTAAGAGTACTATTAGTTACTGCACAATAGCACCAAATTG
TAGACTGGAAAAATATTTCCTAGGTATTTATGTACCAGTGAACCTGACAGATTAGTTTGGGACTGGAGTTCTAATGTTGATATGAATCAA
CTTTATTCCTTATATAGCTGGCACCAGGTGGTCAAAAGGCTGACTATAAAATACAGATGCAGGAGGATTGTTAAAATAGACATAAGTGCA
CTGTGCAAAATACATCTGTTTACTTAAATCTATGAGAAAATTAAATGAAGGGTTCAAACAGAAATTAACAATTAGTGAAAACAGATGTAG
TGCTTTAAAAAAAAACAAAAACAAAAAACTACAGATATAACACATTTTTACCCGGAACTTTGAAAGGTAAAAAGCGATTGCTATACAACA
TCATAAAACATTCCAGTTTGTTCTGTCTTCCTTTATAACAAAAACAAAAAGTACAATGCCAAAAAAAAAAAAAACTCTACACAGTCTTGC
ATAATAAAGACAAGCTGCTTCAATCAAATGCACCATCACAACAAATGCAGTTAACAGCATTGCTGCCTCACTTTCCAAGCCTATATGCAA
ATTTATTCCTTTACTTTTGTTAAAAGTCCAAGTGGGTATCATATGCCTATTTATTCTCAGAGTGCCAAAATTTCCAATATTCCTACTATG
AATCTTACCCTCGCAATTACTAAATAGAGGTATGACAGTCAAGTTCATTAAACGAATGAGTTTTGGTTTTATAATAGACAACCTAATCCT
CTACTACCACCCCAAGTAGCTTAAGAATGATATGATGGCCTGAAACAGTAAAAAGTGGGATGTTTGGGAGTATTACCTGGGACCTATATA
TTTCTGATATGTTCTTGATTATAAACAGATGGACAGATTCAATTTCAAGACAGTGTGACTACCATTCCTGTTGGAGTATTATAGAAATAC
AAGACACTAAACTGAGTAAACATTCTCCTGGGCTAGAAGGGAAGGCAGTGGTACACTCAGTAGGAAACAGCAAGTGATGTGTTAATACAG
CATGGTCTGCGCCACAGAATTCTACTGTGTACAGTTGCTTTCTGTGTGACTCAGGAAGTTCAAGAAGGCAAATTCCAAAACACCTAAAGC
ATATAAACTAATTTAAAAGAACTGTTTTGCAATCCATCATCCTTAGTTTTTAACCAAATTCAGGAAATGCAGTTTTATATAACCTGGAAC
AGAATGAACTGTAGTTACCCTACGTTGTCATAAACCATCAGTAGTTTTGTTAAGTATGATTGTTCACAACAGGTTATACATACATGCAGA
ATATAATGATAGCTGCAACCTCACAAATTAGGGCTAGAAAGTACAATGCTAATGTGTAAATTTCCAAGTTGCTTTTTAAACACTGGGTGG
ATTTCAAAGGAATGTGTGTCTTTAAAGGTGAACTGATGGCATTTTATCGAGAAAGTTCAGAGCTGGGCTATGGACTTCTGAAGCAGCAGT
TCACTGGCCGCCTAAAATAATAATTGTGATAAAGGTCACCAACTCCAGAACTGGGCCAAGGAATGCAGGAAGAATTTATTCATTAATGCA
AACATTTTTAGGTTTAGCTAATTCCGTAGAGGCAGGATCTTGATTATGTATAATAGTTAAAATAACTTTTCAGTTCACCTGTTGGGAAAT

>1977_1977_3_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000360635_length(amino acids)=254AA_BP=0
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ

--------------------------------------------------------------
>1977_1977_4_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000238091_length(transcript)=1952nt_BP=637nt
CGCCACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGC
CGGGCGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGC
CGGGAACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCC
CCACCAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAG
AGATCTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGA
ACGTTTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACA
CGTGGTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAA
CATAGAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATC
AGATCAATATGAACAAGCACAAGCCATTTGCAAGGTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCA
ATCAAGTAGAAGTCAACTTCATCTGAAAGTTCAGCTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCT
CTAGATTTTCTGAAGAAAATGGATTGTGTAAAATGCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATG
AAGTCATCTATTTTCTGGGCTAAAAAACTTCATTTGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCA
CAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAG
GCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACT
CAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGA
CGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACA
CACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACA
GAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGA
GGAAGACTGAGGACATGGGCTCAGTGGTGGCTTCCCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGAC
CAGGATTCATGCTGGTCTGGAACAGTGACATTGCCAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTG
GCCAACCACAATTCCTAGAGTTAAGAGAACCTTAAAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTG

>1977_1977_4_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000238091_length(amino acids)=204AA_BP=0
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ

--------------------------------------------------------------
>1977_1977_5_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000355346_length(transcript)=2102nt_BP=637nt
CGCCACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGC
CGGGCGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGC
CGGGAACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCC
CCACCAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAG
AGATCTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGA
ACGTTTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACA
CGTGGTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAA
CATAGAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATC
AGATCAATATGATGTTTTGCACAGGCATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGGGCGGGAAAAAGCTT
ACTGGCTCTGAAGACCACAGATGCAAGCAATGAGGAATACAGCCTGTGGGTTTATCAGTGCAACAGCCTGGAACAAGCACAAGCCATTTG
CAAGGTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCAAGTAGAAGTCAACTTCATCTGAAAGT
TCAGCTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAGATTTTCTGAAGAAAATGGATTGTGTA
AAATGCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGTCATCTATTTTCTGGGCTAAAAAACTT
CATTTGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGAGGTCCACTCAGTGACAAACACACACT
GAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTC
CACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGG
AAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACA
AACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGT
CACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGA
AGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAAGACTGAGGACATGGGCTCAGTGGTGG
CTTCCCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGGATTCATGCTGGTCTGGAACAGTGACA
TTGCCAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCAACCACAATTCCTAGAGTTAAGAGAAC
CTTAAAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACTTTTTTTAAAGGACTGTCAATATACAA

>1977_1977_5_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000355346_length(amino acids)=254AA_BP=0
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ

--------------------------------------------------------------
>1977_1977_6_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000360635_length(transcript)=4311nt_BP=637nt
CGCCACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGC
CGGGCGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGC
CGGGAACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCC
CCACCAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAG
AGATCTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGA
ACGTTTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACA
CGTGGTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAA
CATAGAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATC
AGATCAATATGATGTTTTGCACAGGCATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGGGCGGGAAAAAGCTT
ACTGGCTCTGAAGACCACAGATGCAAGCAATGAGGAATACAGCCTGTGGGTTTATCAGTGCAACAGCCTGGAACAAGCACAAGCCATTTG
CAAGGTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCAAGTAGAAGTCAACTTCATCTGAAAGT
TCAGCTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAGATTTTCTGAAGAAAATGGATTGTGTA
AAATGCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGTCATCTATTTTCTGGGCTAAAAAACTT
CATTTGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGAGGTCCACTCAGTGACAAACACACACT
GAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTC
CACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGG
AAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACA
AACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGT
CACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGA
AGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAAGACTGAGGACATGGGCTCAGTGGTGG
CTTCCCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGGATTCATGCTGGTCTGGAACAGTGACA
TTGCCAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCAACCACAATTCCTAGAGTTAAGAGAAC
CTTAAAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACTTTTTTTAAAGGACTGTCAATATACAA
AACTTTAAAGATTAAAAACATTAAAAATAAAACCATGTCCATTTAAAAGTATTTTATTTTTTTCCAGTCAAATGACTAGTTAACAAGAAG
AGTAAACTTATTAAACATGCTCTAATTATAAATCACTGCATTAAGGACAATGAAAATAATCAATTTCGGTTATACAATATATACAGTTGT
GCTGCAACCAAAGTAATCAGGTGAATGAACTGAATATCATACATCTCAAAATAGCATCCTAAGCTGCATATTATGTTATCCACCCCTTAA
CAGATCACACAGTTACTCTTAGTCTGTGTACATGTTCTGAGCCATCATCCCAGATCTGATGGAGAATGGCATGCAAAATGCCAGAATCCT
GCAGCTGCAGTTCATGAAACATAAACTTTAAATATAAATAGATATCTACAATGTTTTTCTTTCTCTTAGTTGCTTTTTTAATTTGCAAGG
AGCAAATAACTAAGAAAGGATATTAGCAGGGTCGTTAATATAATTTCTCCTCTGGTAAGAGTACTATTAGTTACTGCACAATAGCACCAA
ATTGTAGACTGGAAAAATATTTCCTAGGTATTTATGTACCAGTGAACCTGACAGATTAGTTTGGGACTGGAGTTCTAATGTTGATATGAA
TCAACTTTATTCCTTATATAGCTGGCACCAGGTGGTCAAAAGGCTGACTATAAAATACAGATGCAGGAGGATTGTTAAAATAGACATAAG
TGCACTGTGCAAAATACATCTGTTTACTTAAATCTATGAGAAAATTAAATGAAGGGTTCAAACAGAAATTAACAATTAGTGAAAACAGAT
GTAGTGCTTTAAAAAAAAACAAAAACAAAAAACTACAGATATAACACATTTTTACCCGGAACTTTGAAAGGTAAAAAGCGATTGCTATAC
AACATCATAAAACATTCCAGTTTGTTCTGTCTTCCTTTATAACAAAAACAAAAAGTACAATGCCAAAAAAAAAAAAAACTCTACACAGTC
TTGCATAATAAAGACAAGCTGCTTCAATCAAATGCACCATCACAACAAATGCAGTTAACAGCATTGCTGCCTCACTTTCCAAGCCTATAT
GCAAATTTATTCCTTTACTTTTGTTAAAAGTCCAAGTGGGTATCATATGCCTATTTATTCTCAGAGTGCCAAAATTTCCAATATTCCTAC
TATGAATCTTACCCTCGCAATTACTAAATAGAGGTATGACAGTCAAGTTCATTAAACGAATGAGTTTTGGTTTTATAATAGACAACCTAA
TCCTCTACTACCACCCCAAGTAGCTTAAGAATGATATGATGGCCTGAAACAGTAAAAAGTGGGATGTTTGGGAGTATTACCTGGGACCTA
TATATTTCTGATATGTTCTTGATTATAAACAGATGGACAGATTCAATTTCAAGACAGTGTGACTACCATTCCTGTTGGAGTATTATAGAA
ATACAAGACACTAAACTGAGTAAACATTCTCCTGGGCTAGAAGGGAAGGCAGTGGTACACTCAGTAGGAAACAGCAAGTGATGTGTTAAT
ACAGCATGGTCTGCGCCACAGAATTCTACTGTGTACAGTTGCTTTCTGTGTGACTCAGGAAGTTCAAGAAGGCAAATTCCAAAACACCTA
AAGCATATAAACTAATTTAAAAGAACTGTTTTGCAATCCATCATCCTTAGTTTTTAACCAAATTCAGGAAATGCAGTTTTATATAACCTG
GAACAGAATGAACTGTAGTTACCCTACGTTGTCATAAACCATCAGTAGTTTTGTTAAGTATGATTGTTCACAACAGGTTATACATACATG
CAGAATATAATGATAGCTGCAACCTCACAAATTAGGGCTAGAAAGTACAATGCTAATGTGTAAATTTCCAAGTTGCTTTTTAAACACTGG
GTGGATTTCAAAGGAATGTGTGTCTTTAAAGGTGAACTGATGGCATTTTATCGAGAAAGTTCAGAGCTGGGCTATGGACTTCTGAAGCAG
CAGTTCACTGGCCGCCTAAAATAATAATTGTGATAAAGGTCACCAACTCCAGAACTGGGCCAAGGAATGCAGGAAGAATTTATTCATTAA
TGCAAACATTTTTAGGTTTAGCTAATTCCGTAGAGGCAGGATCTTGATTATGTATAATAGTTAAAATAACTTTTCAGTTCACCTGTTGGG

>1977_1977_6_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000360635_length(amino acids)=254AA_BP=0
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ADAM17-ITGB1BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneITGB1BP1chr2:9675962chr2:9548334ENST0000023809136139_14196.0151.0ITGB1
TgeneITGB1BP1chr2:9675962chr2:9548334ENST0000035534637139_14196.0201.0ITGB1
TgeneITGB1BP1chr2:9675962chr2:9548334ENST0000036063548139_14196.0201.0ITGB1
TgeneITGB1BP1chr2:9675962chr2:9548334ENST0000048845147139_14196.0151.0ITGB1
TgeneITGB1BP1chr2:9675962chr2:9548334ENST0000023809136136_13996.0151.0KRIT1
TgeneITGB1BP1chr2:9675962chr2:9548334ENST0000035534637136_13996.0201.0KRIT1
TgeneITGB1BP1chr2:9675962chr2:9548334ENST0000036063548136_13996.0201.0KRIT1
TgeneITGB1BP1chr2:9675962chr2:9548334ENST0000048845147136_13996.0151.0KRIT1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ADAM17-ITGB1BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ADAM17-ITGB1BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAM17C3280501INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 12CTD_human;GENOMICS_ENGLAND
HgeneADAM17C0005758Bulla1CTD_human
HgeneADAM17C0009319Colitis1CTD_human
HgeneADAM17C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneADAM17C3860213Autoinflammatory disorder1GENOMICS_ENGLAND
HgeneADAM17C4751120Neonatal inflammatory skin and bowel disease1ORPHANET
TgeneC0005941Bone Diseases, Developmental1CTD_human
TgeneC0376634Craniofacial Abnormalities1CTD_human