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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ADAM17-ITGB1BP1 (FusionGDB2 ID:HG6868TG9270) |
Fusion Gene Summary for ADAM17-ITGB1BP1 |
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Fusion gene information | Fusion gene name: ADAM17-ITGB1BP1 | Fusion gene ID: hg6868tg9270 | Hgene | Tgene | Gene symbol | ADAM17 | ITGB1BP1 | Gene ID | 6868 | 9270 |
Gene name | ADAM metallopeptidase domain 17 | integrin subunit beta 1 binding protein 1 | |
Synonyms | ADAM18|CD156B|CSVP|NISBD|NISBD1|TACE | ICAP-1A|ICAP-1B|ICAP-1alpha|ICAP1|ICAP1A|ICAP1B | |
Cytomap | ('ADAM17')('ITGB1BP1') 2p25.1 | 2p25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | disintegrin and metalloproteinase domain-containing protein 17ADAM metallopeptidase domain 18TNF-alpha convertaseTNF-alpha converting enzymesnake venom-like proteasetumor necrosis factor, alpha, converting enzyme | integrin beta-1-binding protein 1bodeninintegrin cytoplasmic domain-associated protein 1integrin cytoplasmic domain-associated protein 1-alphaintegrin cytoplasmic domain-associated protein 1-beta | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000310823, ENST00000497134, | ||
Fusion gene scores | * DoF score | 6 X 8 X 6=288 | 4 X 4 X 3=48 |
# samples | 11 | 5 | |
** MAII score | log2(11/288*10)=-1.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ADAM17 [Title/Abstract] AND ITGB1BP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ADAM17(9695638)-ITGB1BP1(9558861), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | ADAM17-ITGB1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM17-ITGB1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM17-ITGB1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM17-ITGB1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADAM17 | GO:0001666 | response to hypoxia | 18276953 |
Hgene | ADAM17 | GO:0006508 | proteolysis | 24227843 |
Hgene | ADAM17 | GO:0006509 | membrane protein ectodomain proteolysis | 9034190|9574564|17786981|18676862 |
Hgene | ADAM17 | GO:0007155 | cell adhesion | 14970227 |
Hgene | ADAM17 | GO:0007173 | epidermal growth factor receptor signaling pathway | 12743035 |
Hgene | ADAM17 | GO:0007220 | Notch receptor processing | 24226769 |
Hgene | ADAM17 | GO:0032496 | response to lipopolysaccharide | 18383040 |
Hgene | ADAM17 | GO:0033627 | cell adhesion mediated by integrin | 14970227 |
Hgene | ADAM17 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 24813629 |
Hgene | ADAM17 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 18483258 |
Hgene | ADAM17 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis | 14625290|15691827|17010968 |
Hgene | ADAM17 | GO:0071403 | cellular response to high density lipoprotein particle stimulus | 17786981 |
Hgene | ADAM17 | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 24813629 |
Tgene | ITGB1BP1 | GO:0002043 | blood vessel endothelial cell proliferation involved in sprouting angiogenesis | 20616313 |
Tgene | ITGB1BP1 | GO:0006469 | negative regulation of protein kinase activity | 20616313 |
Tgene | ITGB1BP1 | GO:0007160 | cell-matrix adhesion | 9281591 |
Tgene | ITGB1BP1 | GO:0007229 | integrin-mediated signaling pathway | 11919189|15703214 |
Tgene | ITGB1BP1 | GO:0008284 | positive regulation of cell proliferation | 15703214 |
Tgene | ITGB1BP1 | GO:0008285 | negative regulation of cell proliferation | 20616313 |
Tgene | ITGB1BP1 | GO:0010595 | positive regulation of endothelial cell migration | 20616313 |
Tgene | ITGB1BP1 | GO:0032091 | negative regulation of protein binding | 12473654 |
Tgene | ITGB1BP1 | GO:0032148 | activation of protein kinase B activity | 20616313 |
Tgene | ITGB1BP1 | GO:0035148 | tube formation | 20616313 |
Tgene | ITGB1BP1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 20616313 |
Tgene | ITGB1BP1 | GO:0043087 | regulation of GTPase activity | 11807099 |
Tgene | ITGB1BP1 | GO:0044344 | cellular response to fibroblast growth factor stimulus | 20616313 |
Tgene | ITGB1BP1 | GO:0045747 | positive regulation of Notch signaling pathway | 20616313 |
Tgene | ITGB1BP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15703214|20616313 |
Tgene | ITGB1BP1 | GO:0051895 | negative regulation of focal adhesion assembly | 12473654 |
Tgene | ITGB1BP1 | GO:0051897 | positive regulation of protein kinase B signaling | 20616313 |
Tgene | ITGB1BP1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 20616313 |
Tgene | ITGB1BP1 | GO:0072659 | protein localization to plasma membrane | 17916086 |
Tgene | ITGB1BP1 | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | 20616313 |
Tgene | ITGB1BP1 | GO:0090315 | negative regulation of protein targeting to membrane | 11807099 |
Tgene | ITGB1BP1 | GO:0097746 | regulation of blood vessel diameter | 20616313 |
Tgene | ITGB1BP1 | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 11807099 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | HNSC | TCGA-CR-7389-01A | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
ChimerDB4 | HNSC | TCGA-CR-7389 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
ChimerDB4 | STAD | TCGA-CD-5813 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
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Fusion Gene ORF analysis for ADAM17-ITGB1BP1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000310823 | ENST00000238091 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000310823 | ENST00000355346 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000310823 | ENST00000359712 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000310823 | ENST00000359712 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
5CDS-5UTR | ENST00000310823 | ENST00000360635 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000310823 | ENST00000456913 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000310823 | ENST00000456913 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
5CDS-5UTR | ENST00000310823 | ENST00000488451 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000310823 | ENST00000488451 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
5CDS-5UTR | ENST00000310823 | ENST00000490426 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
5CDS-5UTR | ENST00000497134 | ENST00000238091 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000497134 | ENST00000355346 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000497134 | ENST00000359712 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000497134 | ENST00000359712 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
5CDS-5UTR | ENST00000497134 | ENST00000360635 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000497134 | ENST00000456913 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000497134 | ENST00000456913 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
5CDS-5UTR | ENST00000497134 | ENST00000488451 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-5UTR | ENST00000497134 | ENST00000488451 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
5CDS-5UTR | ENST00000497134 | ENST00000490426 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
5CDS-intron | ENST00000310823 | ENST00000490426 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
5CDS-intron | ENST00000497134 | ENST00000490426 | ADAM17 | chr2 | 9695638 | - | ITGB1BP1 | chr2 | 9558861 | - |
In-frame | ENST00000310823 | ENST00000238091 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
In-frame | ENST00000310823 | ENST00000355346 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
In-frame | ENST00000310823 | ENST00000360635 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
In-frame | ENST00000497134 | ENST00000238091 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
In-frame | ENST00000497134 | ENST00000355346 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
In-frame | ENST00000497134 | ENST00000360635 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000310823 | ADAM17 | chr2 | 9675962 | - | ENST00000360635 | ITGB1BP1 | chr2 | 9548334 | - | 4307 | 633 | 183 | 947 | 254 |
ENST00000310823 | ADAM17 | chr2 | 9675962 | - | ENST00000238091 | ITGB1BP1 | chr2 | 9548334 | - | 1948 | 633 | 183 | 797 | 204 |
ENST00000310823 | ADAM17 | chr2 | 9675962 | - | ENST00000355346 | ITGB1BP1 | chr2 | 9548334 | - | 2098 | 633 | 183 | 947 | 254 |
ENST00000497134 | ADAM17 | chr2 | 9675962 | - | ENST00000360635 | ITGB1BP1 | chr2 | 9548334 | - | 4311 | 637 | 187 | 951 | 254 |
ENST00000497134 | ADAM17 | chr2 | 9675962 | - | ENST00000238091 | ITGB1BP1 | chr2 | 9548334 | - | 1952 | 637 | 187 | 801 | 204 |
ENST00000497134 | ADAM17 | chr2 | 9675962 | - | ENST00000355346 | ITGB1BP1 | chr2 | 9548334 | - | 2102 | 637 | 187 | 951 | 254 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000310823 | ENST00000360635 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - | 0.00050711 | 0.9994929 |
ENST00000310823 | ENST00000238091 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - | 0.002639142 | 0.9973609 |
ENST00000310823 | ENST00000355346 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - | 0.002094149 | 0.99790585 |
ENST00000497134 | ENST00000360635 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - | 0.000507027 | 0.999493 |
ENST00000497134 | ENST00000238091 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - | 0.002278636 | 0.9977214 |
ENST00000497134 | ENST00000355346 | ADAM17 | chr2 | 9675962 | - | ITGB1BP1 | chr2 | 9548334 | - | 0.001738299 | 0.99826175 |
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Fusion Genomic Features for ADAM17-ITGB1BP1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ADAM17-ITGB1BP1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:9695638/chr2:9558861) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 96_99 | 150 | 825.0 | Compositional bias | Note=Poly-Val |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 564_602 | 150 | 825.0 | Compositional bias | Note=Cys-rich |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 223_474 | 150 | 825.0 | Domain | Peptidase M12B |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 475_563 | 150 | 825.0 | Domain | Disintegrin |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 182_189 | 150 | 825.0 | Motif | Cysteine switch |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 731_738 | 150 | 825.0 | Motif | SH3-binding |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 741_748 | 150 | 825.0 | Motif | SH3-binding |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 603_671 | 150 | 825.0 | Region | Note=Crambin-like |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 215_671 | 150 | 825.0 | Topological domain | Extracellular |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 693_824 | 150 | 825.0 | Topological domain | Cytoplasmic |
Hgene | ADAM17 | chr2:9675962 | chr2:9548334 | ENST00000310823 | - | 4 | 19 | 672_692 | 150 | 825.0 | Transmembrane | Helical |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000238091 | 3 | 6 | 10_57 | 96 | 151.0 | Compositional bias | Note=Ser/Thr-rich | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000355346 | 3 | 7 | 10_57 | 96 | 201.0 | Compositional bias | Note=Ser/Thr-rich | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000360635 | 4 | 8 | 10_57 | 96 | 201.0 | Compositional bias | Note=Ser/Thr-rich | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000488451 | 4 | 7 | 10_57 | 96 | 151.0 | Compositional bias | Note=Ser/Thr-rich | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000238091 | 3 | 6 | 58_200 | 96 | 151.0 | Domain | Note=PID | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000355346 | 3 | 7 | 58_200 | 96 | 201.0 | Domain | Note=PID | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000360635 | 4 | 8 | 58_200 | 96 | 201.0 | Domain | Note=PID | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000488451 | 4 | 7 | 58_200 | 96 | 151.0 | Domain | Note=PID |
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Fusion Gene Sequence for ADAM17-ITGB1BP1 |
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>1977_1977_1_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000238091_length(transcript)=1948nt_BP=633nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATCAGAT CAATATGAACAAGCACAAGCCATTTGCAAGGTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCA AGTAGAAGTCAACTTCATCTGAAAGTTCAGCTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAG ATTTTCTGAAGAAAATGGATTGTGTAAAATGCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGT CATCTATTTTCTGGGCTAAAAAACTTCATTTGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGA GGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCT GAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGT GACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAG ATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACA CTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGG TCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAA GACTGAGGACATGGGCTCAGTGGTGGCTTCCCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGG ATTCATGCTGGTCTGGAACAGTGACATTGCCAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCA ACCACAATTCCTAGAGTTAAGAGAACCTTAAAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACT >1977_1977_1_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000238091_length(amino acids)=204AA_BP=0 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ -------------------------------------------------------------- >1977_1977_2_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000355346_length(transcript)=2098nt_BP=633nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATCAGAT CAATATGATGTTTTGCACAGGCATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGGGCGGGAAAAAGCTTACTG GCTCTGAAGACCACAGATGCAAGCAATGAGGAATACAGCCTGTGGGTTTATCAGTGCAACAGCCTGGAACAAGCACAAGCCATTTGCAAG GTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCAAGTAGAAGTCAACTTCATCTGAAAGTTCAG CTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAGATTTTCTGAAGAAAATGGATTGTGTAAAAT GCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGTCATCTATTTTCTGGGCTAAAAAACTTCATT TGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAG GCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACT CAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGA CTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACA CACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACA GAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGC CTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAAGACTGAGGACATGGGCTCAGTGGTGGCTTC CCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGGATTCATGCTGGTCTGGAACAGTGACATTGC CAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCAACCACAATTCCTAGAGTTAAGAGAACCTTA AAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACTTTTTTTAAAGGACTGTCAATATACAAAACT >1977_1977_2_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000355346_length(amino acids)=254AA_BP=0 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ -------------------------------------------------------------- >1977_1977_3_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000360635_length(transcript)=4307nt_BP=633nt ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA GAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATCAGAT CAATATGATGTTTTGCACAGGCATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGGGCGGGAAAAAGCTTACTG GCTCTGAAGACCACAGATGCAAGCAATGAGGAATACAGCCTGTGGGTTTATCAGTGCAACAGCCTGGAACAAGCACAAGCCATTTGCAAG GTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCAAGTAGAAGTCAACTTCATCTGAAAGTTCAG CTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAGATTTTCTGAAGAAAATGGATTGTGTAAAAT GCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGTCATCTATTTTCTGGGCTAAAAAACTTCATT TGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAG GCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACT CAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGA CTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACA CACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACA GAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGC CTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAAGACTGAGGACATGGGCTCAGTGGTGGCTTC CCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGGATTCATGCTGGTCTGGAACAGTGACATTGC CAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCAACCACAATTCCTAGAGTTAAGAGAACCTTA AAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACTTTTTTTAAAGGACTGTCAATATACAAAACT TTAAAGATTAAAAACATTAAAAATAAAACCATGTCCATTTAAAAGTATTTTATTTTTTTCCAGTCAAATGACTAGTTAACAAGAAGAGTA AACTTATTAAACATGCTCTAATTATAAATCACTGCATTAAGGACAATGAAAATAATCAATTTCGGTTATACAATATATACAGTTGTGCTG CAACCAAAGTAATCAGGTGAATGAACTGAATATCATACATCTCAAAATAGCATCCTAAGCTGCATATTATGTTATCCACCCCTTAACAGA TCACACAGTTACTCTTAGTCTGTGTACATGTTCTGAGCCATCATCCCAGATCTGATGGAGAATGGCATGCAAAATGCCAGAATCCTGCAG CTGCAGTTCATGAAACATAAACTTTAAATATAAATAGATATCTACAATGTTTTTCTTTCTCTTAGTTGCTTTTTTAATTTGCAAGGAGCA AATAACTAAGAAAGGATATTAGCAGGGTCGTTAATATAATTTCTCCTCTGGTAAGAGTACTATTAGTTACTGCACAATAGCACCAAATTG TAGACTGGAAAAATATTTCCTAGGTATTTATGTACCAGTGAACCTGACAGATTAGTTTGGGACTGGAGTTCTAATGTTGATATGAATCAA CTTTATTCCTTATATAGCTGGCACCAGGTGGTCAAAAGGCTGACTATAAAATACAGATGCAGGAGGATTGTTAAAATAGACATAAGTGCA CTGTGCAAAATACATCTGTTTACTTAAATCTATGAGAAAATTAAATGAAGGGTTCAAACAGAAATTAACAATTAGTGAAAACAGATGTAG TGCTTTAAAAAAAAACAAAAACAAAAAACTACAGATATAACACATTTTTACCCGGAACTTTGAAAGGTAAAAAGCGATTGCTATACAACA TCATAAAACATTCCAGTTTGTTCTGTCTTCCTTTATAACAAAAACAAAAAGTACAATGCCAAAAAAAAAAAAAACTCTACACAGTCTTGC ATAATAAAGACAAGCTGCTTCAATCAAATGCACCATCACAACAAATGCAGTTAACAGCATTGCTGCCTCACTTTCCAAGCCTATATGCAA ATTTATTCCTTTACTTTTGTTAAAAGTCCAAGTGGGTATCATATGCCTATTTATTCTCAGAGTGCCAAAATTTCCAATATTCCTACTATG AATCTTACCCTCGCAATTACTAAATAGAGGTATGACAGTCAAGTTCATTAAACGAATGAGTTTTGGTTTTATAATAGACAACCTAATCCT CTACTACCACCCCAAGTAGCTTAAGAATGATATGATGGCCTGAAACAGTAAAAAGTGGGATGTTTGGGAGTATTACCTGGGACCTATATA TTTCTGATATGTTCTTGATTATAAACAGATGGACAGATTCAATTTCAAGACAGTGTGACTACCATTCCTGTTGGAGTATTATAGAAATAC AAGACACTAAACTGAGTAAACATTCTCCTGGGCTAGAAGGGAAGGCAGTGGTACACTCAGTAGGAAACAGCAAGTGATGTGTTAATACAG CATGGTCTGCGCCACAGAATTCTACTGTGTACAGTTGCTTTCTGTGTGACTCAGGAAGTTCAAGAAGGCAAATTCCAAAACACCTAAAGC ATATAAACTAATTTAAAAGAACTGTTTTGCAATCCATCATCCTTAGTTTTTAACCAAATTCAGGAAATGCAGTTTTATATAACCTGGAAC AGAATGAACTGTAGTTACCCTACGTTGTCATAAACCATCAGTAGTTTTGTTAAGTATGATTGTTCACAACAGGTTATACATACATGCAGA ATATAATGATAGCTGCAACCTCACAAATTAGGGCTAGAAAGTACAATGCTAATGTGTAAATTTCCAAGTTGCTTTTTAAACACTGGGTGG ATTTCAAAGGAATGTGTGTCTTTAAAGGTGAACTGATGGCATTTTATCGAGAAAGTTCAGAGCTGGGCTATGGACTTCTGAAGCAGCAGT TCACTGGCCGCCTAAAATAATAATTGTGATAAAGGTCACCAACTCCAGAACTGGGCCAAGGAATGCAGGAAGAATTTATTCATTAATGCA AACATTTTTAGGTTTAGCTAATTCCGTAGAGGCAGGATCTTGATTATGTATAATAGTTAAAATAACTTTTCAGTTCACCTGTTGGGAAAT >1977_1977_3_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000310823_ITGB1BP1_chr2_9548334_ENST00000360635_length(amino acids)=254AA_BP=0 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ -------------------------------------------------------------- >1977_1977_4_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000238091_length(transcript)=1952nt_BP=637nt CGCCACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGC CGGGCGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGC CGGGAACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCC CCACCAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAG AGATCTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGA ACGTTTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACA CGTGGTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAA CATAGAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATC AGATCAATATGAACAAGCACAAGCCATTTGCAAGGTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCA ATCAAGTAGAAGTCAACTTCATCTGAAAGTTCAGCTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCT CTAGATTTTCTGAAGAAAATGGATTGTGTAAAATGCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATG AAGTCATCTATTTTCTGGGCTAAAAAACTTCATTTGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCA CAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAG GCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACT CAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGA CGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACA CACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACA GAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGA GGAAGACTGAGGACATGGGCTCAGTGGTGGCTTCCCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGAC CAGGATTCATGCTGGTCTGGAACAGTGACATTGCCAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTG GCCAACCACAATTCCTAGAGTTAAGAGAACCTTAAAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTG >1977_1977_4_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000238091_length(amino acids)=204AA_BP=0 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ -------------------------------------------------------------- >1977_1977_5_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000355346_length(transcript)=2102nt_BP=637nt CGCCACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGC CGGGCGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGC CGGGAACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCC CCACCAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAG AGATCTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGA ACGTTTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACA CGTGGTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAA CATAGAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATC AGATCAATATGATGTTTTGCACAGGCATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGGGCGGGAAAAAGCTT ACTGGCTCTGAAGACCACAGATGCAAGCAATGAGGAATACAGCCTGTGGGTTTATCAGTGCAACAGCCTGGAACAAGCACAAGCCATTTG CAAGGTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCAAGTAGAAGTCAACTTCATCTGAAAGT TCAGCTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAGATTTTCTGAAGAAAATGGATTGTGTA AAATGCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGTCATCTATTTTCTGGGCTAAAAAACTT CATTTGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGAGGTCCACTCAGTGACAAACACACACT GAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTC CACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGG AAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACA AACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGT CACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGA AGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAAGACTGAGGACATGGGCTCAGTGGTGG CTTCCCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGGATTCATGCTGGTCTGGAACAGTGACA TTGCCAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCAACCACAATTCCTAGAGTTAAGAGAAC CTTAAAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACTTTTTTTAAAGGACTGTCAATATACAA >1977_1977_5_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000355346_length(amino acids)=254AA_BP=0 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ -------------------------------------------------------------- >1977_1977_6_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000360635_length(transcript)=4311nt_BP=637nt CGCCACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGC CGGGCGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGC CGGGAACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCC CCACCAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAG AGATCTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGA ACGTTTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACA CGTGGTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAA CATAGAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATC AGATCAATATGATGTTTTGCACAGGCATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGGGCGGGAAAAAGCTT ACTGGCTCTGAAGACCACAGATGCAAGCAATGAGGAATACAGCCTGTGGGTTTATCAGTGCAACAGCCTGGAACAAGCACAAGCCATTTG CAAGGTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCAAGTAGAAGTCAACTTCATCTGAAAGT TCAGCTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAGATTTTCTGAAGAAAATGGATTGTGTA AAATGCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGTCATCTATTTTCTGGGCTAAAAAACTT CATTTGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGAGGTCCACTCAGTGACAAACACACACT GAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTC CACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGG AAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACA AACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGT CACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGA AGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAAGACTGAGGACATGGGCTCAGTGGTGG CTTCCCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGGATTCATGCTGGTCTGGAACAGTGACA TTGCCAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCAACCACAATTCCTAGAGTTAAGAGAAC CTTAAAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACTTTTTTTAAAGGACTGTCAATATACAA AACTTTAAAGATTAAAAACATTAAAAATAAAACCATGTCCATTTAAAAGTATTTTATTTTTTTCCAGTCAAATGACTAGTTAACAAGAAG AGTAAACTTATTAAACATGCTCTAATTATAAATCACTGCATTAAGGACAATGAAAATAATCAATTTCGGTTATACAATATATACAGTTGT GCTGCAACCAAAGTAATCAGGTGAATGAACTGAATATCATACATCTCAAAATAGCATCCTAAGCTGCATATTATGTTATCCACCCCTTAA CAGATCACACAGTTACTCTTAGTCTGTGTACATGTTCTGAGCCATCATCCCAGATCTGATGGAGAATGGCATGCAAAATGCCAGAATCCT GCAGCTGCAGTTCATGAAACATAAACTTTAAATATAAATAGATATCTACAATGTTTTTCTTTCTCTTAGTTGCTTTTTTAATTTGCAAGG AGCAAATAACTAAGAAAGGATATTAGCAGGGTCGTTAATATAATTTCTCCTCTGGTAAGAGTACTATTAGTTACTGCACAATAGCACCAA ATTGTAGACTGGAAAAATATTTCCTAGGTATTTATGTACCAGTGAACCTGACAGATTAGTTTGGGACTGGAGTTCTAATGTTGATATGAA TCAACTTTATTCCTTATATAGCTGGCACCAGGTGGTCAAAAGGCTGACTATAAAATACAGATGCAGGAGGATTGTTAAAATAGACATAAG TGCACTGTGCAAAATACATCTGTTTACTTAAATCTATGAGAAAATTAAATGAAGGGTTCAAACAGAAATTAACAATTAGTGAAAACAGAT GTAGTGCTTTAAAAAAAAACAAAAACAAAAAACTACAGATATAACACATTTTTACCCGGAACTTTGAAAGGTAAAAAGCGATTGCTATAC AACATCATAAAACATTCCAGTTTGTTCTGTCTTCCTTTATAACAAAAACAAAAAGTACAATGCCAAAAAAAAAAAAAACTCTACACAGTC TTGCATAATAAAGACAAGCTGCTTCAATCAAATGCACCATCACAACAAATGCAGTTAACAGCATTGCTGCCTCACTTTCCAAGCCTATAT GCAAATTTATTCCTTTACTTTTGTTAAAAGTCCAAGTGGGTATCATATGCCTATTTATTCTCAGAGTGCCAAAATTTCCAATATTCCTAC TATGAATCTTACCCTCGCAATTACTAAATAGAGGTATGACAGTCAAGTTCATTAAACGAATGAGTTTTGGTTTTATAATAGACAACCTAA TCCTCTACTACCACCCCAAGTAGCTTAAGAATGATATGATGGCCTGAAACAGTAAAAAGTGGGATGTTTGGGAGTATTACCTGGGACCTA TATATTTCTGATATGTTCTTGATTATAAACAGATGGACAGATTCAATTTCAAGACAGTGTGACTACCATTCCTGTTGGAGTATTATAGAA ATACAAGACACTAAACTGAGTAAACATTCTCCTGGGCTAGAAGGGAAGGCAGTGGTACACTCAGTAGGAAACAGCAAGTGATGTGTTAAT ACAGCATGGTCTGCGCCACAGAATTCTACTGTGTACAGTTGCTTTCTGTGTGACTCAGGAAGTTCAAGAAGGCAAATTCCAAAACACCTA AAGCATATAAACTAATTTAAAAGAACTGTTTTGCAATCCATCATCCTTAGTTTTTAACCAAATTCAGGAAATGCAGTTTTATATAACCTG GAACAGAATGAACTGTAGTTACCCTACGTTGTCATAAACCATCAGTAGTTTTGTTAAGTATGATTGTTCACAACAGGTTATACATACATG CAGAATATAATGATAGCTGCAACCTCACAAATTAGGGCTAGAAAGTACAATGCTAATGTGTAAATTTCCAAGTTGCTTTTTAAACACTGG GTGGATTTCAAAGGAATGTGTGTCTTTAAAGGTGAACTGATGGCATTTTATCGAGAAAGTTCAGAGCTGGGCTATGGACTTCTGAAGCAG CAGTTCACTGGCCGCCTAAAATAATAATTGTGATAAAGGTCACCAACTCCAGAACTGGGCCAAGGAATGCAGGAAGAATTTATTCATTAA TGCAAACATTTTTAGGTTTAGCTAATTCCGTAGAGGCAGGATCTTGATTATGTATAATAGTTAAAATAACTTTTCAGTTCACCTGTTGGG >1977_1977_6_ADAM17-ITGB1BP1_ADAM17_chr2_9675962_ENST00000497134_ITGB1BP1_chr2_9548334_ENST00000360635_length(amino acids)=254AA_BP=0 MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ADAM17-ITGB1BP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000238091 | 3 | 6 | 139_141 | 96.0 | 151.0 | ITGB1 | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000355346 | 3 | 7 | 139_141 | 96.0 | 201.0 | ITGB1 | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000360635 | 4 | 8 | 139_141 | 96.0 | 201.0 | ITGB1 | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000488451 | 4 | 7 | 139_141 | 96.0 | 151.0 | ITGB1 | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000238091 | 3 | 6 | 136_139 | 96.0 | 151.0 | KRIT1 | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000355346 | 3 | 7 | 136_139 | 96.0 | 201.0 | KRIT1 | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000360635 | 4 | 8 | 136_139 | 96.0 | 201.0 | KRIT1 | |
Tgene | ITGB1BP1 | chr2:9675962 | chr2:9548334 | ENST00000488451 | 4 | 7 | 136_139 | 96.0 | 151.0 | KRIT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADAM17-ITGB1BP1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ADAM17-ITGB1BP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADAM17 | C3280501 | INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 1 | 2 | CTD_human;GENOMICS_ENGLAND |
Hgene | ADAM17 | C0005758 | Bulla | 1 | CTD_human |
Hgene | ADAM17 | C0009319 | Colitis | 1 | CTD_human |
Hgene | ADAM17 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | ADAM17 | C3860213 | Autoinflammatory disorder | 1 | GENOMICS_ENGLAND |
Hgene | ADAM17 | C4751120 | Neonatal inflammatory skin and bowel disease | 1 | ORPHANET |
Tgene | C0005941 | Bone Diseases, Developmental | 1 | CTD_human | |
Tgene | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |